Yaqi Yu, Leilei Yu, Xingting Zhou, Nanzhen Qiao, Dingwu Qu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen
BACKGROUND AND OBJECTIVES: Lead (Pb) has been reported to disturb the metabolism of essential elements, such as calcium (Ca), magnesium (Mg), iron (Fe) and zinc (Zn) in vivo. This study focused on the relationship between various dose of Pb and the essential elements. METHODS: 50 healthy male C57BL/6 mice underwent oral administration of 0.2 mL lead acetate trihydrate solution (0, 20, 100, 500, and 1000 mg Pb/day/kg body weight) for 3 days. The concentrations of Pb and four essential elements (Ca, Zn, Fe and Mg) in the blood, kidney, liver, bone and brain were quantified with inductively coupled plasma mass spectrometry...
December 2020: Journal of Trace Elements in Medicine and Biology