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Ashish Kumar Jena, Karan Vasisht, Neetika Sharma, Ramdeep Kaur, Mamta Sachdeva Dhingra, Maninder Karan
ETHNOPHARMACOLOGICAL RELEVANCE: Benign prostatic hyperplasia (BPH) is a common urological disorder of men. The ethnomedicinal use of an African plant Prunus africana (Hook.f.) Kalkman (Pygeum) in treating men's problems made it a popular remedy all over the globe for the treatment of BPH and related disorders. However, rampant collections made from the wild in Africa have pushed the plant to Appendix II of CITES demanding conservation of the species. AIM OF THE STUDY: In the present study, the aim was to unearth the protective effect of bark of different species of Prunus against BPH...
August 22, 2016: Journal of Ethnopharmacology
Aryeh Keehn, Jacob Taylor, Franklin C Lowe
INTRODUCTION: The use of complementary and alternative medications for symptomatic benign prostatic hyperplasia is a lucrative business in the USA with revenues reaching close to US$6.4 billion in sales for the 2014 fiscal year. Yet, despite its popularity, the evidence supporting the continued use of phytotherapy for symptomatic benign prostatic hyperplasia (BPH) is questionable and a topic worth investigation given its wide spread use. METHODS: A comprehensive literature search utilizing Medline and PubMed was conducted to identify literature pertaining to phytotherapy for the management of BPH...
July 2016: Current Urology Reports
G Belcaro, M Dugall, R Luzzi, A Ledda, L Pellegrini, M Hosoi, B M Errichi, S Francis, U Cornelli
The aim of this registry was to evaluate the management of initial symptoms of benign prostatic hyperthrophy (BPH) in otherwise healthy subjects, using Prostaquil® (Alchem) in a 8-week registry. Prostaquil was used at the dosage of 200 mg/day. The product includes Pygeum extract (100 mg) and Saw palmetto oil (35 mg). The two resulting groups standard management and supplement) were comparable. RESULTS: No side effects or comparability problems were observed and compliance was optimal with more than 95% of the capsules correctly used...
October 22, 2015: Minerva Gastroenterologica e Dietologica
Olta Allkanjari, Annabella Vitalone
Benign prostatic hyperplasia (BPH) is one of the most common urological diseases in aging men. Because of its long latency, BPH is a good target for prevention. The aim of the study has been to review the various options of treatment, currently available, in the field of phytotherapy. Watchful waiting, pharmacological therapy, and surgery are also helpful, depending on the severity of the disease. Although drug therapy (alpha1-blockers, 5alpha-reductase inhibitors) and surgery (prostatectomy, transurethral resection, etc...
April 1, 2015: Life Sciences
Ryan Pearson, Pamela M Williams
Benign prostatic hyperplasia (BPH) is a common condition that increases in prevalence with age. A history should include onset, duration, and severity of lower urinary tract symptoms and medication use to rule out other causes of symptoms. Physical examination includes a digital rectal examination and assessment for bladder distention or neurologic impairment. Recommended tests include serum prostate-specific antigen measurement and urinalysis to help identify infection, genitourinary cancer, or calculi as an alternative cause of lower urinary tract symptoms...
December 1, 2014: American Family Physician
Ester Pagano, Massimiliano Laudato, Michele Griffo, Raffaele Capasso
Benign prostate hyperplasia (BPH) is a common condition affecting older men, with an incidence that is age-dependent. Histological BPH, which typically develops after the age of 40 years, ranges in prevalence from >50% at 60 years to as high as 90% by 85 years of age. Typical symptoms include increased frequency of urination, nocturia, urgency, hesitancy, and weak urine stream. Conventional medicines used for the treatment of BPH include alpha blockers and 5-alpha reductase inhibitors. This articles review the mode of action, the efficacy, and the safety, including herb-drug interactions of the most common botanicals (Serenoa repens, Pygeum africanum, Urtica dioica, and Cucurbita pepo) and nutraceuticals (isoflavones, lycopene, selenium, and β-Sitosterol) in controlling the lower urinary tract symptoms associated to BPH...
July 2014: Phytotherapy Research: PTR
X Game, J-N Cornu, G Robert, A Descazeaud, S Droupy, A Benard-Laribiere, C Bastide, L Guy, F Bruyére, G Karsenty
AIM: To describe drugs targeting urethra and prostate to treat dysfunctions such LUTS related to BPH, primary bladder neck obstruction (PBNO), detrusor sphincter dyssynergia (DSD) or sphincter deficiency (SD). METHOD: Pubmed search for efficacy, mode of action and side effects for each molecule. Additional data were searched from the French regulatory agencies web sites (HAS and ANSM). RESULTS: To treat LUTS related to BPH alpha-blockers (AB) and 5-alpha reductase inhibitors (5ARIs) have a clearer efficacy than plant extract...
November 2013: Progrès en Urologie
Philippa J Cheetham
Phytotherapy, the use of plant based extracts (derived from fruits, seeds, roots, or bark) as medicines or health-promoting agents are often used as first-line treatments for bothersome male lower urinary tract symptoms (LUTS). Their use, either as monotherapy or in conjunction with conventional pharmaceutical treatments is becoming increasingly popular worldwide. There are now over 30 of these phytotherapeutic compounds available, with saw palmetto and pygeum being the most widely used. This paper discusses the mechanism of action, reported efficacies and potential side effects of a number of the most common phytotherapies being used for male LUTS, as well as summarizes outcome data relevant to these agents from the most current peer-reviewed publications...
December 2013: Current Urology Reports
G Weise
No abstract text is available yet for this article.
March 1999: International Journal of Pharmaceutical Compounding
Giorgio I Russo, Sebastiano Cimino, Costanza Salamone, Massimo Madonia, Vincenzo Favilla, Tommaso Castelli, Giuseppe Morgia
Traditional medicine is very popular in Africa and it is considered as an alternative form of health care. Plants and vegetables used in folk and traditional medicine have gained wide acceptance as one of the main sources of prophylactic and chemopreventive drug discovery and this is due to the evidence of particular biological and biochemical characteristics of each plants extracts. The role of these compounds in urological field may be explained by the antiinflammatory effect through interference with prostaglandin metabolism, alteration of lipid peroxidation, direct inhibition of prostate growth and moreover through an antiandrogenic or antiestrogenic effect and a decrease of the availability of sex hormone-binding globulin...
October 2013: Mini Reviews in Medicinal Chemistry
Samantha Coulson, Amanda Rao, Shoshannah L Beck, Elizabeth Steels, Helen Gramotnev, Luis Vitetta
OBJECTIVE: The aim of the clinical trial was to evaluate the efficacy and safety of ProstateEZE Max, an orally dosed herbal preparation containing Cucurbita pepo, Epilobium parviflorum, lycopene, Pygeum africanum and Serenoa repens in the management of symptoms of medically diagnosed benign prostate hypertrophy (BPH). DESIGN: This was a short-term phase II randomized double-blind placebo controlled clinical trial. SETTING: The trial was conducted on 57 otherwise healthy males aged 40-80 years that presented with medically diagnosed BPH...
June 2013: Complementary Therapies in Medicine
Barbara Vinceti, Judy Loo, Hannes Gaisberger, Maarten J van Zonneveld, Silvio Schueler, Heino Konrad, Caroline A C Kadu, Thomas Geburek
Conservation priorities for Prunus africana, a tree species found across Afromontane regions, which is of great commercial interest internationally and of local value for rural communities, were defined with the aid of spatial analyses applied to a set of georeferenced molecular marker data (chloroplast and nuclear microsatellites) from 32 populations in 9 African countries. Two approaches for the selection of priority populations for conservation were used, differing in the way they optimize representation of intra-specific diversity of P...
2013: PloS One
Caroline A C Kadu, Heino Konrad, Silvio Schueler, Geoffrey M Muluvi, Oscar Eyog-Matig, Alice Muchugi, Vivienne L Williams, Lolona Ramamonjisoa, Consolatha Kapinga, Bernard Foahom, Cuthbert Katsvanga, David Hafashimana, Crisantos Obama, Thomas Geburek
BACKGROUND AND AIMS: Afromontane forest ecosystems share a high similarity of plant and animal biodiversity, although they occur mainly on isolated mountain massifs throughout the continent. This resemblance has long provoked questions on former wider distribution of Afromontane forests. In this study Prunus africana (one of the character trees of Afromontane forests) is used as a model for understanding the biogeography of this vegetation zone. METHODS: Thirty natural populations from nine African countries covering a large part of Afromontane regions were analysed using six nuclear microsatellites...
January 2013: Annals of Botany
R W Hartmann, M Mark, F Soldati
This study was undertaken to evaluate a possible effect of the extracts PY102 of Pygeum africanum (Hook), and UR 102 of Urtica dioica L. as well as their combination PHL-00801 (Prostatonin®) on the enzymes 5 α-reductase (5 α-RE) and aromatase (AR): Inhibition of 5 α-RE: Pygeum africanum extract PY 102, and Urtica dioica extract UR 102, inhibited the 5 α-RE activity in a concentration dependent manner. Whereas UR102 extract was only able to influence the enzyme activity at high concentrations (≥ 12mg/ml) and its ED(50) being calculated as 14...
September 1996: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Marianne Schmidt, Christine Polednik, Jeanette Roller, Rudolf Hagen
Previously, a growth inhibiting effect of PC-Spes on head and neck carcinoma cell lines had been demonstrated. In order to determine the toxic impact of particular herbs in the mixture, we exposed the head and neck cancer cell lines FADU, HLaC79 and its Paclitaxel-resistant subline HLaC79-Clone1 as well as primary mucosal keratinocytes to increasing concentrations of the herbal mixture Prostaprotect, which has a similar formulation as PC-Spes, as well as its single herbal components Dendranthema morifolium, Ganoderma lucidium, Glycyrrhiza glabra, Isatis indigotica, Panax pseudo-ginseng, Rabdosia rubescens, Scutellaria baicalensis and Pygeum africanum...
February 2013: Oncology Reports
E Morán, A Budía, E Broseta, F Boronat
OBJECTIVE: To evaluate the usefulness of phytotherapy in the treatment of the benign prostatic hyperplasia (BPH) and prostatic adenocarcinoma (ADCP). ACQUISITION OF EVIDENCE: Systematic review of the evidence published until January 2011 using the following scientific terms: phytotherapy, benign prostate hyperplasia, prostatic adenocarcinoma, prostate cancer and the scientific names of compounds following the rules of the International Code of Botanical Nomenclature...
February 2013: Actas Urologicas Españolas
Sandra M Bach, Marina E Perotti, Ana P Merep, Guillermo E Marcial, Alfredo Grau, Rodgoun Attarian, Yossef Av-Gay, Horacio Bach, César A N Catalán
The anti-inflammatory, antioxidant, antimicrobial and cytotoxic activities of the hexane (HE), chloroform (CE) and methanol (ME) extracts obtained from the bark of Prunus tucumanensis Lillo were investigated. Both ME and CE extracts displayed a significant in vitro anti-inflammatory activity similar to dexamethasone and to a commercial formulation (Pygeum) used for the treatment of benign prostatic hyperplasia (BPH). ME exhibited powerful antioxidant (67.6% relative to BHT) and free radical scavenging (RC50 = 5 ppm) activities, antimicrobial activities against Staphylococcus aureus and Mycobacterium smegmatis and did not show any cytotoxic effect on human-derived macrophage cells...
2013: Natural Product Research
Tae-Hun Kim, Hyun-Ja Lim, Myung-Sunny Kim, Myeong Soo Lee
Benign prostatic hyperplasia (BPH) is a common chronic condition in older men. The aim of this overview of systematic reviews (SRs) is to summarise the current evidence on the efficacy and adverse effects of dietary supplements for treating BPH with lower urinary tract symptoms. We searched 5 electronic databases and relevant overviews without limitations on language or publication status. Six SRs of 195 articles were included in this overview. Serenoa repens was reviewed in 3 studies and no specific effect on BPH symptoms and urinary flow measures was observed...
November 2012: Maturitas
Caroline A C Kadu, Alexandra Parich, Silvio Schueler, Heino Konrad, Geoffrey M Muluvi, Oscar Eyog-Matig, Alice Muchugi, Vivienne L Williams, Lolona Ramamonjisoa, Consolatha Kapinga, Bernard Foahom, Cuthbert Katsvanga, David Hafashimana, Crisantos Obama, Barbara Vinceti, Rainer Schumacher, Thomas Geburek
Prunus africana--an evergreen tree found in Afromontane forests--is used in traditional medicine to cure benign prostate hyperplasia. Different bioactive constituents derived from bark extracts from 20 tree populations sampled throughout the species' natural range in Africa were studied by means of GC-MSD. The average concentration [mg/kgw/w] in increasing order was: lauric acid (18), myristic acid (22), n-docosanol (25), ferulic acid (49), β-sitostenone (198), β-sitosterol (490), and ursolic acid (743). The concentrations of many bark constituents were significantly correlated and concentration of n-docosanol was highly significantly correlated with all other analytes...
November 2012: Phytochemistry
Hanieh Azimi, Ali-Asghar Khakshur, Iman Aghdasi, Mehrnaz Fallah-Tafti, Mohammad Abdollahi
OBJECTIVE: In this paper, we reviewed plants being effective in treatment of BPH for the purpose of finding new sources of pharmaceutical agents. METHODS: All pertinent literature databases were searched. The search keywords were plant, herb, herbal therapy, phytotherapy, benign prostatic hyperplasia, BPH, and prostate. All of the human, animal and in vitro studies were evaluated. RESULTS: According to the studies, some of the substantial effective constituents of the plants in treatment of BPH are oenothein B, icaritin, xanthohumol, diarylheptanoid, 2,6,4'-trihydroxy-4-methoxybenzophenone, emodin, fatty acids, atraric acid, n-butylbenzene-sulfonamide, curbicin, theaflavin-3,30-digallate, penta-O-galloyl-b-D-glucose, lycopene, sinalbin, β-sitosterol, secoisolariciresinol diglucoside, genistein, apigenin, baicalein, and daidzein...
June 2012: Inflammation & Allergy Drug Targets
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