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https://www.readbyqxmd.com/read/28528089/production-of-highly-concentrated-oil-in-water-emulsions-using-dual-channel-microfluidization-use-of-individual-and-mixed-natural-emulsifiers-saponin-and-lecithin
#1
Xiang Luo, Yanyan Zhou, Long Bai, Fuguo Liu, Ruojie Zhang, Zipei Zhang, Bingjing Zheng, Yihui Deng, David Julian McClements
The fabrication of concentrated oil-in-water emulsions is useful for reducing storage and transportation costs, as well as for providing desirable textural, optical, stability, and release characteristics in commercial products. In this study, 50wt% oil-in-water emulsions were produced from natural emulsifiers using high-pressure dual-channel microfluidization (89.6MPa, 1 pass). The particle size and charge characteristics of emulsions stabilized using a hydrophilic biosurfactant (quillaja saponin) or mixtures of hydrophilic and hydrophobic biosurfactants (quillaja saponin+soy lecithin) were measured...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28516478/determination-of-oral-bioavailability-of-curcuminoid-dispersions-and-nanoemulsions-prepared-from-curcuma-longa-linnaeus
#2
P S Lu, B S Inbaraj, B H Chen
BACKGROUND: Curcuminoid from Curcuma longa Linnaeus has been demonstrated to be effective in anti-cancer and anti-inflammation. The objectives of this study were to prepare curcuminoid dispersion and nanoemulsion from C. longa and determine their oral bioavailability in rats. RESULTS: After curcuminoid extraction using 99.5% ethanol, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and curcumin were separated within 10 min by HPLC with an Eclipse XDB-C18 column and a gradient mobile phase of 0...
May 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28509615/mining-of-a-phospholipase-d-and-its-application-in-enzymatic-preparation-of-phosphatidylserine
#3
Wen-Bin Zhou, Jin-Song Gong, Hai-Juan Hou, Heng Li, Zhen-Ming Lu, Hong-Yu Xu, Zheng-Hong Xu, Jin-Song Shi
Phosphatidylserine (PS) is useful as the additive in industries for memory improvement, mood enhancement and drug delivery. Conventionally, PS was extracted from soybeans, vegetable oils, egg yolk, and biomass; however, their low availability and high extraction cost were limiting factors. Phospholipase D (PLD) is a promising tool for enzymatic synthesis of PS due to its transphosphatidylation activity. In this contribution, a new and uncharacterized PLD was first obtained from GenBank database via genome mining strategy...
May 16, 2017: Bioengineered
https://www.readbyqxmd.com/read/28508975/a-case-of-acquired-lecithin-cholesterol-acyltransferase-deficiency-with-sarcoidosis-that-remitted-spontaneously
#4
Tanino Akiko, Takafumi Okura, Tomoaki Nagao, Masayoshi Kukida, Daijiro Enomoto, Ken-Ichi Miyoshi, Jitsuo Higaki, Masayuki Kuroda, Hideaki Bujo
Familial lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare inherited disorder that causes an extremely low high-density lipoprotein cholesterol concentration in serum. Recently, acquired LCAT deficiency caused by IgG antibodies to LCAT, without any LCAT gene mutation, was reported. Here we describe a case of acquired LCAT deficiency occurring in association with sarcoidosis. The patient was a Japanese female aged 70 years, had no mutation in the LCAT gene exon sequence, but had an LCAT inhibitor factor in her serum, detected using lipoprotein-deficient serum...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28508023/an-unusual-presentation-of-lcat-deficiency-as-nephrotic-syndrome-with-normal-serum-hdl-c-level
#5
Manish R Balwani, Vijaykumar A Ghodela, Vivek B Kute, Pankaj R Shah, Himanshu V Patel, Dinesh N Gera, Aruna Vanikar, Hargovind L Trivedi
Clinical and biochemical manifestations of lecithin-cholesterol acyltransferase (LCAT) deficiency include an abnormal lipid profile (characterized by hypercholesterolemia with markedly decreased high-density lipoprotein cholesterol [HDL-C] and hypertriglyceridemia), corneal opacities, hematologic abnormalities (normochromic anemia of varying intensity), splenomegaly, variable early coronary artery disease and nephropathy (initially proteinuria followed by progressive deterioration of renal function). We presented a patient with nephrotic syndrome, which renal biopsy revealed classic features of LCAT deficiency...
2017: Journal of Nephropharmacology
https://www.readbyqxmd.com/read/28504138/hybrid-pectin-based-biosorbents-for-zinc-ions-removal
#6
Agata Jakóbik-Kolon, Joanna Bok-Badura, Krzysztof Karoń, Krzysztof Mitko, Andrzej Milewski
In this paper, a set of the hybrid biosorbents, made of pectin and polysaccharide additives (arabic, tragacanth, guar, karaya, xanthan, gellan, carob gums, agar-agar) or lecithin (phospholipid), was investigated and tested for zinc ions removal. The immobilization of the polysaccharides into the pectin matrix was proved by the IR spectroscopy. The structure of the working biosorbents was observed in SEM micrographs. The influence of the additive type and pH on the sorption properties and swelling index was investigated...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28501703/xanthohumol-a-hop-derived-prenylated-flavonoid-promotes-macrophage-reverse-cholesterol-transport
#7
Hiroshi Hirata, Harumi Uto-Kondo, Masatsune Ogura, Makoto Ayaori, Kazusa Shiotani, Ami Ota, Youichi Tsuchiya, Katsunori Ikewaki
Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important antiatherogenic property of HDL; therefore, we investigated the effects of xanthohumol on macrophage-to-feces RCT using a hamster model as a CETP-expressing species. In vivo RCT experiments showed that xanthohumol significantly increased fecal appearance of the tracer derived from intraperitoneally injected [(3)H]-cholesterol-labeled macrophages...
April 22, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28500977/endocytosis-and-intracellular-traffic-of-cholesterol-pdmaema-liposome-complexes-in-human-epithelial-like-cells
#8
F Szymanowski, A A Hugo, P Alves, P N Simões, A Gómez-Zavaglia, Pablo F Pérez
Liposomes are generally used as delivery systems, as they are capable of encapsulating a wide variety of molecules (i.e. plasmids, recombinant proteins, therapeutic drugs). However, liposomal drug delivery have to fulfill different requirements, such as the effective internalization by the target cells and avoidance of the degradative activity of the intracellular compartments. The use of polymer lipid complexes (PLCs), by including different polymers in the liposome formulation, could improve internalization and intracellular release of drugs...
May 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28496322/photoresponsive-nanocapsulation-of-cobra-neurotoxin-and-enhancement-of-its-central-analgesic-effects-under-red-light
#9
Qian Yang, Chuang Zhao, Jun Zhao, Yong Ye
Cobra neurotoxin (CNT), a peptide isolated from snake venom of Naja naja atra, shows central analgesic effects in our previous research. In order to help CNT pass through blood-brain barrier (BBB) and improve its central analgesic effects, a new kind of CNT nanocapsules were prepared by double emulsification with soybean lecithin and cholesterol as the shell, and pheophorbide as the photosensitizer added to make it photoresponsive. The analgesic effects were evaluated by hot plate test and acetic acid-induced writhing in mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28481539/reverse-micelles-as-antioxidant-carriers-an-experimental-and-molecular-dynamics-study
#10
Maria D Chatzidaki, Konstantinos D Papavasileiou, Manthos G Papadopoulos, Aristotelis Xenakis
Water-in-oil microemulsions with biocompatible components were formulated to be used as carriers of natural antioxidants, such as hydroxytyrosol (HT) and gallic acid (GA). The system was composed of a mixture of natural surfactants, lecithin and monoglycerides, medium chain triglycerides and aqueous phase. A dual approach was undertaken to study the structure and dynamics of these complicated systems. First, experimental data were collected by using adequate techniques, such as Dynamic Light Scattering (DLS) and Electron Paramagnetic Resonance (EPR) Spectroscopy...
May 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28472908/targeted-nanostructured-lipid-carriers-for-delivery-of-paclitaxel-to-cancer-cells-preparation-characterization-and-cell-toxicity
#11
Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh, Hojjat Sadeghi, Mahboubeh Rostami, Hamid Mohammadkhani
Low water solubility, high systemic toxicity and insignificant cellular uptake has limited efficient clinical applications of the anti-tumor agent paclitaxel (PTX). To overcome these limitations, a novel nanostructured lipid carrier (NLC) modified with folic acid (FA) and polyethylene glycol (PEG) was prepared by emulsion solvent evaporation method using cholesterol, α-tocopherol, lecithin and Poloxamer. A partial factorial design was applied to determine the appropriate levels of variables for optimized formulation...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28471688/atherogenic-impact-of-lecithin-cholesterol-acyltransferase-and-its-relation-to-cholesterol-esterification-rate-in-hdl-fer-hdl-and-aip-log-tg-hdl-c-biomarkers-the-butterfly-effect
#12
M Dobiášová
The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins...
May 4, 2017: Physiological Research
https://www.readbyqxmd.com/read/28467186/potential-of-cinnamon-oil-emulsions-as-alternative-washing-solutions-of-carrots
#13
Yue Zhang, Huaiqiong Chen, Faith Critzer, P Michael Davidson, Qixin Zhong
The objective of this study was to evaluate the potential of cinnamon oil emulsions as alternative washing solutions to improve the microbial safety of carrots. Whey protein concentrate (WPC), gum arabic (GA), lecithin, and their combinations were used to prepare cinnamon oil emulsions. The emulsions were characterized for their hydrodynamic diameter (Dh) during 7 days of storage and their antimicrobial activity against cocktails of Salmonella enterica , Escherichia coli O157:H7, and Listeria monocytogenes ...
May 3, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28465473/platelet-derived-growth-factor-receptor-%C3%AE-in-hepatocellular-carcinoma-is-a-prognostic-marker-independent-of-underlying-liver-cirrhosis
#14
Jung-Hwan Yu, Joon Mee Kim, Ja Kyung Kim, Suk Jin Choi, Kwan Sik Lee, Jin-Woo Lee, Hye Young Chang, Jung Il Lee
BACKGROUND AND AIMS: Platelet-derived growth factor receptor alpha (PDGFRα) is suggested as a prognosis marker for hepatocellular carcinoma (HCC). Since PDGFRα is also known as a marker for activated hepatic stellate cells (HSCs), this study aimed to investigate whether PDGFRα expression in HCC was dependent on the background liver fibrous condition. RESULTS: Strong PDGFRα expression in the tumor lesions was associated with decreased survival after curative HCC resection...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28462499/incorporation-of-lipolysis-in-monolayer-permeability-studies-of-lipid-based-oral-drug-delivery-systems
#15
Tanmoy Sadhukha, Buddhadev Layek, Swayam Prabha
Lipid-based drug delivery systems, a well-tolerated class of formulations, have been evaluated extensively to enhance the bioavailability of poorly soluble drugs. However, it has been difficult to predict the in vivo performance of lipid dosage forms based on conventional in vitro techniques such as cell monolayer permeability studies because of the complexity of the gastrointestinal processing of lipid formulations. In the current study, we explored the feasibility of coupling Caco-2 and Madin-Darby canine kidney monolayer permeability studies with lipolysis, a promising in vitro technique to evaluate lipid systems...
May 1, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28461265/preparation-and-characterization-of-isoniazid-loaded-crude-soybean-lecithin-liposomes
#16
Christian Isalomboto Nkanga, Rui Werner Krause, Xavier Siwe Noundou, Roderick Bryan Walker
Tuberculosis (TB) is a poverty related infectious disease that is rapidly giving rise to public health concerns. Lengthy drug administration and frequent adverse side-effects associated with TB treatment make anti-tubercular drugs (ATDs) good candidates for drug delivery studies. This work aimed to formulate and prepare liposomes as a cost-effective option for ATD delivery. Liposomes were prepared by film hydration using crude soybean lecithin (CL) and not pure phospholipids as in the normal practice. Cholesterol was also used (up to 25% mass ratio), and isoniazid (INH) was encapsulated as model drug using a freeze-thaw loading technique...
April 29, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28459714/xxk-regulates-rct-via-improving-hdl-synthesis-maturation-and-catabolism
#17
Guang-Xin Dong, Wen-Wen Li, Ruo-Zhu Wang, Wen-Jun Zou, Zhen-Dong Zhong, Bo-Gang Li
Di'ao Xinxuekang (XXK) is a herbal product in China and Netherlands that has been clinically shown to attenuate atherosclerosis (AS); however, the underlying anti-atherosclerotic mechanism remains unclear. Due to its role in cholesterol homeostasis, reverse cholesterol transport (RCT) is a potential target for these beneficial effects. This study investigated the effects of XXK on RCT and related proteins. After treating ApoE-deficient mice with XXK for 8 weeks, we observed an increase in the expression level of ATP binding cassette transporter A1 (ABCA1) and ATP binding cassette transporter G1 (ABCG1), which in turn stimulated cholesterol efflux and reduced aortic atherosclerotic lesion area...
April 25, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28457552/lactation-performance-of-holstein-cows-treated-with-2-formulations-of-recombinant-bovine-somatotropin-in-a-large-commercial-dairy-herd-in-brazil
#18
J P G de Morais, A P da S Cruz, N S Minami, L P Veronese, T A Del Valle, J Aramini
The objectives of this controlled study were to compare the effects of 2 different formulations of recombinant bovine somatotropin (rbST) on milk yield, milk composition (fat and protein), milk somatic cell count, and body condition score (BCS) among dairy cattle in a large commercial herd. Regulatory approved 500-mg zinc sesame oil base rbST (ZSO-rbST; Elanco Animal Health, Greenfield, IN) and vitamin E lecithin base rbST (VEL-rbST; LG Life Sciences, Seoul, South Korea) formulations were administered per the manufacturers' recommendations every 14 d over 17 injection cycles starting at 57 to 70 d of lactation (90 cows per rbST group)...
April 27, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28457464/alginate-based-nanocomposite-for-microencapsulation-of-probiotic-effect-of-cellulose-nanocrystal-cnc-and-lecithin
#19
Tanzina Huq, Carole Fraschini, Avik Khan, Bernard Riedl, Jean Bouchard, Monique Lacroix
Probiotic (Lactobacillus rhamnosus ATCC 9595) was encapsulated in alginate-CNC-lecithin microbeads to produce nutraceutical microcapsules. Addition of CNC and lecithin in alginate microbeads (ACL-1) improved the viability of L. rhamnosus during gastric passage and storage. The compression strength of the freeze-dried ACL-1 microbeads improved 40% compared to alginate microbeads alone. Swelling studies revealed that addition of CNC and lecithin in alginate microbeads decreased (around 47%) the gastric fluid absorption but increased the dissolution time by 20min compared to alginate microbeads (A-0)...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28456653/montmorillonite-lipid-hybrid-carriers-for-ionizable-and-neutral-poorly-water-soluble-drugs-formulation-characterization-and-in-vitro-lipolysis-studies
#20
Tahnee J Dening, Shasha Rao, Nicky Thomas, Clive A Prestidge
Lipid-based formulations (LBFs) are a popular strategy for enhancing the gastrointestinal solubilization and absorption of poorly water-soluble drugs. In light of this, montmorillonite-lipid hybrid (MLH) particles, composed of medium-chain triglycerides, lecithin and montmorillonite clay platelets, have been developed as a novel solid-state LBF. Owing to the unique charge properties of montmorillonite, whereby the clay platelet surfaces carry a permanent negative charge and the platelet edges carry a pH-dependent charge, three model poorly water-soluble drugs with different charge properties; blonanserin (weak base, pKa 7...
April 27, 2017: International Journal of Pharmaceutics
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