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lecithin

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https://www.readbyqxmd.com/read/28077734/intake-of-up-to-3-eggs-per-day-is-associated-with-changes-in-hdl-function-and-increased-plasma-antioxidants-in-healthy-young-adults
#1
Diana M DiMarco, Gregory H Norris, Courtney L Millar, Christopher N Blesso, Maria Luz Fernandez
BACKGROUND: HDL function may be more important than HDL concentration in determining risk for cardiovascular disease. In addition, HDL is a carrier of carotenoids and antioxidant enzymes, which protect HDL and LDL particles against oxidation. OBJECTIVE: The goal of this study was to determine the impact of consuming 0-3 eggs/d on LDL and HDL particle size, HDL function, and plasma antioxidants in a young, healthy population. METHODS: Thirty-eight healthy men and women [age 18-30 y, body mass index (in kg/m(2)) 18...
January 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28071801/formation-and-characterization-of-green-tea-extract-loaded-liposomes
#2
Damla Dag, Mecit Halil Oztop
Green tea extract was encapsulated into liposomes to enhance bioavailability and stability of catechins by protecting their functional properties simultaneously. Encapsulation was achieved by dispersing 1% (w/v) soy lecithin through high pressure homogenization (microfluidization) and ultrasonication. Effects of homogenization type and pH of the dispersing medium on the physical properties and stability of the liposomes during 1-mo storage period were investigated. Mean particle size, total phenolic content by Folin-Ciocalteu method and antioxidant activity by 2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reducing-antioxidant power methods, and transmission electron microscopy (TEM) experiments were conducted for characterization...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28070713/porous-mannitol-carrier-for-pulmonary-delivery-of-cyclosporine-a-nanoparticles
#3
Sharon Shui Yee Leung, Jennifer Wong, Heloisa Victorino Guerra, Kevin Samnick, Robert K Prud'homme, Hak-Kim Chan
This study employed the ultrasonic spray-freeze-drying technique to prepare porous mannitol carriers that incorporated hydrophobic cyclosporine A (CsA) nanoparticles (NPs) for pulmonary delivery. Two nanosuspension stabilization systems, (1) a combination of lecithin and lactose system and (2) a D-α-tocopheryl polyethylene glycol succinate (TPGS) system, were investigated. The ability of the lecithin and TPGS in anchoring the hydrophobic CsA NPs to the porous hydrophilic mannitol structure was first reported...
January 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28069118/microstructural-textural-and-sensory-properties-of-whole-wheat-noodle-modified-by-enzymes-and-emulsifiers
#4
Meng Niu, Gary G Hou, Julie Kindelspire, Padmanaban Krishnan, Siming Zhao
With the utilization of enzymes including endoxylanase, glucose oxidase (GOX) and transglutaminase (TG), and emulsifiers comprising sodium stearoyl lactate (SSL) and soy lecithin, the microstructural, textural, and sensory properties of whole-wheat noodle (WWN) were modified. The development time and stability of whole-wheat dough (WWD) were enhanced by TG due to the formation of a more compact gluten network, and by SSL resulting from the enhanced gluten strength. Microstructure graphs by scanning electron microscopy (SEM) verified that TG and SSL promoted the connectivity of gluten network and the coverage of starch granules in WWN...
May 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28057545/preparation-of-aqueous-core-plga-shell-microcapsules-with-mono-nuclear-cores-by-internal-phase-separation-optimization-of-formulation-parameters
#5
Samer R Abulateefeh, Mahmoud Y Alkawareek, Fatema R Abdullah, Alaaldin M Alkilany
Previously our group employed the internal phase separation (IPS) method to produce aqueous core-PLGA shell microcapsules with poly-nuclear core morphologies. This report describes the preparation of the more desired and challenging architecture with mono-nuclear cores. Optimization of formulation parameters including (i) varying the composition of the internal phase, and (ii) incorporating selected organic solvents (DCM, chloroform, methanol and acetonitrile) into the internal phase were systematically evaluated...
January 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28035957/in-vivo-assessment-of-clobetasol-propionate-loaded-lecithin-chitosan-nanoparticles-for-skin-delivery
#6
Taner Şenyiğit, Fabio Sonvico, Alessandra Rossi, Işıl Tekmen, Patrizia Santi, Paolo Colombo, Sara Nicoli, Özgen Özer
The aim of this work was to assess in vivo the anti-inflammatory efficacy and tolerability of clobetasol propionate (CP) loaded lecithin/chitosan nanoparticles incorporated into chitosan gel for topical application (CP 0.005%). As a comparison, a commercial cream (CP 0.05% w/w), and a sodium deoxycholate gel (CP 0.05% w/w) were also evaluated. Lecithin/chitosan nanoparticles were prepared by self-assembling of the components obtained by direct injection of soybean lecithin alcoholic solution containing CP into chitosan aqueous solution...
December 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28035145/the-effect-of-different-emulsifiers-on-the-eggless-cake-properties-containing-wpc
#7
Mohammad Khalilian Movahhed, Mohebbat Mohebbi, Arash Koocheki, Elnaz Milani
The possibility of complete replacement of egg proteins with whey protein concentrate (WPC) and improvement in quality by different emulsifiers was evaluated. Three emulsifiers, including polyglycerol ester (PGE), distilled mono glyceride (DMG) and lecithin were used to bake eggless cakes, containing 8% (w/w) WPC. The response surface analysis was applied to study the effect of emulsifiers on the eggless cake properties. The emulsifiers, individually and interactively, improved the properties of the eggless cakes significantly...
November 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28028754/alteration-of-lysophosphatidylcholine-related-metabolic-parameters-in-the-plasma-of-mice-with-experimental-sepsis
#8
Won-Gyun Ahn, Jun-Sub Jung, Hyeok Yil Kwon, Dong-Keun Song
Plasma concentration of lysophosphatidylcholine (LPC) was reported to decrease in patients with sepsis. However, the mechanisms of sepsis-induced decrease in plasma LPC levels are not currently well known. In mice subjected to cecal ligation and puncture (CLP), a model of polymicrobial peritoneal sepsis, we examined alterations in LPC-related metabolic parameters in plasma, i.e., the plasma concentration of LPC-related substances (i.e., phosphatidylcholine (PC) and lysophosphatidic acid (LPA)), and activities or levels in the plasma of some enzymes that can be involved in the regulation of plasma LPC concentration (i...
December 28, 2016: Inflammation
https://www.readbyqxmd.com/read/28017697/anti-inflammatory-and-antioxidant-effect-of-modified-bazhengsan-in-a-rat-model-of-chronic-bacterial-prostatitis
#9
Youyi Xiong, Xingtao Qiu, Weijing Shi, Hao Yu, Xiaolin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Bazhengsan is a commonly used traditional Chinese prescription for the treatment of the urogenital system diseases for thousands of years, which decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty. AIM OF THE STUDY: In this study, the potential of modified Bazhengsan (mBazhengsan) as a chronic bacterial prostate inflammation inhibitor was investigated in a rat model. MATERIALS AND METHODS: Rat prostates were injected with Escherichia coli to induce inflammation by the sterile operation...
December 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28011116/ethylene-glycol-but-not-dmso-could-replace-glycerol-inclusion-in-soybean-lecithin-based-extenders-in-ram-sperm-cryopreservation
#10
Abouzar Najafi, Hossein Daghigh-Kia, Hossein Vaseghi Dodaran, Mahdieh Mehdipour, Manuel Alvarez-Rodriguez
The aim of this study was to evaluate the effects of glycerol, ethylene glycol or DMSO in a soybean lecithin extender for freezing ram semen. In this study, 20 ejaculates were collected from four Ghezel rams and diluted with soybean lecithin extender with glycerol (7%), ethylene glycol (3%, 5% and 7%) or DMSO (3%, 5% and 7%). Sperm motility (CASA), membrane integrity (HOS test), viability, total abnormality, mitochondrial activity (Rhodamine 123) and apoptotic features (Annexin V/Propidium iodide) were assessed after thawing...
December 8, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27999851/omega-3-fatty-acids-and-vitamin-d-in-immobilisation-part-b-modulation-of-muscle-functional-vascular-and-activation-profiles
#11
E L Bostock, C I Morse, K Winwood, I M McEwan, G L Onambélé
OBJECTIVES: This study set out to determine whether two potential protein-sparing modulators (eicosapentaenoic acid and vitamin D) would modulate the anticipated muscle functional and related blood vessels function deleterious effects of immobilisation. DESIGN: The study used a randomised, double-blind, placebo-controlled design. SETTING: The study took part in a laboratory setting. PARTICIPANTS: Twenty-four male and female healthy participants, aged 23...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27999850/omega-3-fatty-acids-and-vitamin-d-in-immobilisation-part-a-modulation-of-appendicular-mass-content-composition-and-structure
#12
E L Bostock, C I Morse, K Winwood, I M McEwan, G L Onambélé
OBJECTIVES: Muscle size decreases in response to short-term limb immobilisation. This study set out to determine whether two potential protein-sparing modulators (eicosapentaenoic acid and vitamin D) would attenuate immobilisation-induced changes in muscle characteristics. DESIGN: The study used a randomised, double-blind, placebo-controlled design. SETTING: The study took part in a laboratory setting. PARTICIPANTS: Twenty-four male and female healthy participants, aged 23...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27999767/antimicrobial-efficacy-of-the-combination-of-chlorhexidine-digluconate-and-dexpanthenol
#13
Axel Kramer, Ojan Assadian, Torsten Koburger-Janssen
Objective: The objective of this standardised experimental study was to investigate the antimicrobial efficacy of the combination of chlorhexidine digluconate (CHX) and the anti-inflammatory pro-vitamin dexpanthenol, which stimulates wound-healing, in the form of Bepanthen(®) Antiseptic Wound Cream, in order to rule out possible antagonistic combination effects of CHX and the alcohol analogue of pantothenic acid (vitamin B5) dexpanthenol. Method: Testing was carried out using the quantitative suspension test at conditions simulating wound bio-burden...
2016: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/27997610/effective-respiratory-cd8-t-cell-immunity-to-influenza-virus-induced-by-intranasal-carbomer-lecithin-adjuvanted-non-replicating-vaccines
#14
David J Gasper, Brandon Neldner, Erin H Plisch, Hani Rustom, Emily Carrow, Hirotaka Imai, Yoshihiro Kawaoka, M Suresh
CD8+ cytotoxic T lymphocytes (CTLs) are critical for clearing many viral infections, and protective CTL memory can be induced by vaccination with attenuated viruses and vectors. Non-replicating vaccines are typically potentiated by the addition of adjuvants that enhance humoral responses, however few are capable of generating CTL responses. Adjuplex is a carbomer-lecithin-based adjuvant demonstrated to elicit robust humoral immunity to non-replicating antigens. We report that mice immunized with non-replicating Adjuplex-adjuvanted vaccines generated robust antigen-specific CTL responses...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27994459/the-nasal-delivery-of-nanoencapsulated-statins-an-approach-for-brain-delivery
#15
Adryana Clementino, Mellissa Batger, Gabriela Garrastazu, Michele Pozzoli, Elena Del Favero, Valeria Rondelli, Bianca Gutfilen, Thiago Barboza, Maria B Sukkar, Sergio A L Souza, Laura Cantù, Fabio Sonvico
PURPOSE: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration in view of an improved delivery of the statins to the brain...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27987457/synergistic-performance-of-lecithin-and-glycerol-monostearate-in-oil-water-emulsions
#16
María I Moran-Valero, Víctor M Pizones Ruiz-Henestrosa, Ana M R Pilosof
The effects of the combination of two low-molecular weight emulsifiers (lecithin and glycerol-monostearate (GMS)) on the stability, the dynamic interfacial properties and rheology of emulsions have been studied. Different lecithin/GMS ratios were tested in order to assess their impact in the formation and stabilization of oil in water emulsions. The combination of the two surfactants showed a synergistic behaviour, mainly when combined at the same ratio. The dynamic film properties and ζ-potential showed that lecithin dominated the surface of oil droplets, providing stability to the emulsions against flocculation and coalescence, while allowing the formation of small oil droplets...
December 11, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27983946/effect-of-green-tea-camellia-sinensis-extract-and-pre-freezing-equilibration-time-on-the-post-thawing-quality-of-ram-semen-cryopreserved-in-a-soybean-lecithin-based-extender
#17
Mahdieh Mehdipour, Hossein Daghigh Kia, Abouzar Najafi, Hossein Vaseghi Dodaran, Olga García-Álvarez
The aim of this study was to determine the effect of Camellia sinensis extract as antioxidant supplement and pre-freezing equilibration times in a soybean lecithin extender for freezing ram semen. In this study, a total of 20 ejaculates were collected from four Ghezel rams and diluted with extenders (1.5% soybean lecithin, 7% glycerol) containing no supplements (control) and Camellia sinensis extract (5, 10, and 15 mg/L) and cryopreserved, immediately after thermal equilibrium was reached at 5 °C (0 h), or 4 h after equilibration...
October 28, 2016: Cryobiology
https://www.readbyqxmd.com/read/27983556/the-level-of-24-hydroxycholesteryl-esters-is-an-early-marker-of-alzheimer-s-disease
#18
Luisa Benussi, Roberta Ghidoni, Fabrizio Dal Piaz, Giuliano Binetti, Giuseppe Di Iorio, Paolo Abrescia
Cholesterol (C) brain accumulation seems to play a role in the Alzheimer's disease (AD) pathogenesis. 24(S)-hydroxycholesterol (24OH-C) is the predominant metabolite of brain C and its synthesis is believed to represent a way to remove excess C from neurons. Previous studies showed that 24OH-C level is altered in patients with neurodegenerative diseases, including AD. Only one study demonstrated that 24OH-C esterification is altered in neurodegenerative diseases, i.e., amyotrophic lateral sclerosis. Herein we analyzed the level of 24OH-C esters (% 24OH-CE) in i) cerebrospinal fluid (CSF) and homologous serum of AD (n = 13) and controls (n = 8); ii) plasma from AD (n = 30), controls (n = 30), mild cognitive impairment (MCI) converting to AD (n = 34), and stable MCI (n = 40)...
December 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27979201/foam-mat-drying-of-tommy-atkins-mango-effects-of-air-temperature-and-concentrations-of-soy-lecithin-and-carboxymethylcellulose-on-phenolic-composition-mangiferin-and-antioxidant-capacity
#19
Francine Albernaz Lobo, Manuela Abreu Nascimento, Josiane Roberto Domingues, Deborah Quintanilha Falcão, Dolores Hernanz, Francisco J Heredia, Kátia Gomes de Lima Araujo
In this study, foam mat drying was applied to Tommy Atkins mango. Using a multifactorial design, the effect of soy lecithin (L) and carboxymethylcellulose (CMC) used as foam stabilizers (0-1.50g/100g), as well as temperature (T) (53-87°C), on phenolic content and antioxidant capacity of mango were evaluated. Mango pulp contains antioxidant, such as mangiferin, that can be utilized in foods to enhance their functional properties. Our results indicated that L and T had negative effects (p<0.05) on the phenolic content and antioxidant capacity, whereas CMC had a positive effect (p<0...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27977215/-31-p-and-1-h-nmr-studies-of-the-molecular-organization-of-lipids-in-the-parallel-artificial-membrane-permeability-assay
#20
Frauke Assmus, Alfred Ross, Holger Fischer, Joachim Seelig, Anna Seelig
The parallel artificial membrane permeability assay (PAMPA) has emerged as a widely used primary in vitro screen for passive permeability of potential drug candidates. However, the molecular structure of the permeation barrier (consisting of a filter-supported dodecane-egg lecithin mixture) has never been characterized. Here, we investigated the long-range order of phospholipids in the PAMPA barrier by means of (31)P static solid-state NMR. Diffusion constants of PAMPA membrane components were derived from liquid state NMR and, in addition, drug distribution between the PAMPA lipid phase and buffer (log DPAMPA at pH 7...
January 3, 2017: Molecular Pharmaceutics
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