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https://www.readbyqxmd.com/read/27933441/multimodality-imaging-to-assess-immediate-response-following-irreversible-electroporation-in-patients-with-malignant-hepatic-tumors
#1
Katsutoshi Sugimoto, Fuminori Moriyasu, Kazuhiro Saito, Yoshiyuki Kobayashi, Takao Itoi
PURPOSE: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS), contrast-enhanced multiphase CT (CECT), and gadoxetic acid-enhanced MRI (EOB-MRI) in identifying residual tumor in the subacute follow-up of patients with malignant hepatic tumors treated by irreversible electroporation (IRE). METHODS: We enrolled 16 patients with 21 hepatic lesions treated by IRE and examined by CEUS and CECT at 1 day after IRE and by EOB-MRI at 7 days after IRE...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27929673/effect-of-gadoxetate-disodium-on-arterial-phase-respiratory-waveforms-using-a-quantitative-fast-fourier-transformation-based-analysis
#2
Matthew S Davenport, Dariya I Malyarenko, Yuxi Pang, Hero K Hussain, Thomas L Chenevert
OBJECTIVE: The purpose of this study is to investigate the effect of gadoxetate disodium administration on arterial phase respiratory waveforms. SUBJECTS AND METHODS: From 2013 to 2015, 107 subjects undergoing liver MRI with either gadoxetate disodium (10 mL diluted 1:1 with saline; injection rate, 2 mL/s; n = 40) or gadobenate dimeglumine (0.2 mL/kg; maximum, 20 mL; injection rate, 2 mL/s; n = 67) were enrolled. Respiratory waveforms obtained during unenhanced and dynamic contrast-enhanced phases were filtered by a physicist, who was blinded to contrast agent and imaging phase, to eliminate electronic and cardiac noise using fast Fourier transformation...
December 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27903759/intrahepatic-distant-recurrence-after-radiofrequency-ablation-for-hepatocellular-carcinoma-precursor-nodules-on-pre-procedural-gadoxetic-acid-enhanced-liver-magnetic-resonance-imaging
#3
Kyoung Doo Song, Hyunchul Rhim, Min Woo Lee, Young-Sun Kim, Tae Wook Kang
BACKGROUND: Intrahepatic distant recurrence (IDR) after radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) is associated with poor overall survival outcome. PURPOSE: To evaluate the incidence and findings on pre-procedural gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) of precursor nodules for IDR after RF ablation for HCC. MATERIAL AND METHODS: This study was approved by our institutional review board. Among 343 patients treated with RF ablation for HCC between 2009 and 2011, 141 patients who underwent pre-procedural gadoxetic acid-enhanced liver MRI and experienced IDR were enrolled...
November 30, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27875000/combined-hepatocellular-cholangiocarcinoma-gadoxetic-acid-enhanced-mri-findings-correlated-with-pathologic-features-and-prognosis
#4
So Hyun Park, Seung Soo Lee, Eunsil Yu, Hyo Jeong Kang, Yangsoon Park, So Yeon Kim, So Jung Lee, Yong Moon Shin, Moon Gyu Lee
PURPOSE: To evaluate gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings of combined hepatocellular cholangiocarcinoma (cHCC-CC) with special emphasis on correlation of MRI findings with histopathologic tumor characteristics and survival outcomes after curative surgery. MATERIALS AND METHODS: Our Institutional Review Board approved this study, with a waiver of informed consent. For 82 patients (64 men, 18 women; mean age, 54.0 years; age range, 30-81) with surgically confirmed cHCC-CCs, we evaluated clinical features, histologic findings, and tumor morphologic and enhancement features on gadoxetic acid-enhanced liver MRI at 1...
November 22, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27862590/hepatic-gadoxetic-acid-uptake-as-a-measure-of-diffuse-liver-disease-where-are-we
#5
REVIEW
Ahmed Ba-Ssalamah, Nina Bastati, Andreas Wibmer, Romana Fragner, Jacqueline C Hodge, Michael Trauner, Christian J Herold, Mustafa R Bashir, Bernard E Van Beers
: MRI has emerged as the most comprehensive noninvasive diagnostic tool for focal liver lesions and diffuse hepatobiliary disorders. The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, particularly in the functional imaging of chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD). GA-enhanced MRI (GA-MRI) may help to distinguish between the two subgroups of NAFLD, simple steatosis and nonalcoholic steatohepatitis...
November 8, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27835984/qualitative-analysis-of-small-%C3%A2-2%C3%A2-cm-regenerative-nodules-dysplastic-nodules-and-well-differentiated-hccs-with-gadoxetic-acid-mri
#6
Michele Di Martino, Michele Anzidei, Fulvio Zaccagna, Luca Saba, Sandro Bosco, Massimo Rossi, Stefano Ginanni Corradini, Carlo Catalano
BACKGROUND: The characterization of small lesions in cirrhotic patients is extremely difficult due to the overlap of imaging features among different entities in the step-way of the hepatocarcinogenesis. The aim of our study was to evaluate the role of gadoxetic-acid MRI in the differentiation of small (≤2 cm) well-differentiated hepatocellular carcinomas from regenerative and dysplastic nodules. METHODS: Seventy-three cirrhotic patients, with 118 focal liver lesions (≤2 cm) were prospectively recruited...
November 11, 2016: BMC Medical Imaging
https://www.readbyqxmd.com/read/27815722/disappearing-or-residual-tiny-%C3%A2-5%C3%A2-mm-colorectal-liver-metastases-after-chemotherapy-on-gadoxetic-acid-enhanced-liver-mri-and-diffusion-weighted-imaging-is-local-treatment-required
#7
Seung Soo Kim, Kyoung Doo Song, Young Kon Kim, Hee Cheol Kim, Jung Wook Huh, Young Suk Park, Joon Oh Park, Seung Tae Kim
OBJECTIVES: To evaluate the clinical course of disappearing colorectal liver metastases (DLM) or residual tiny (≤5 mm) colorectal liver metastases (RTCLM) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) in patients who had colorectal liver metastases (CLM) and received chemotherapy. METHODS: Among 137 patients who received chemotherapy for CLM and underwent gadoxetic acid-enhanced MRI and DWI between 2010 and 2012, 43 patients with 168 DLMs and 48 RTCLMs were included...
November 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27807654/gallbladder-opacification-on-gadoxetate-disodium-enhanced-ct-scan
#8
Adib R Karam, Eduardo Scortegagna, Byron Y Chen, Carolyn S Dupuis, Dennis D Coughlin
This study aimed to evaluate the radiologist's ability to identify excreted gadoxetate disodium within the gallbladder on CT scan. Thirty three healthy adults underwent imaging of the liver during work-up for potential liver donation. Three patients had undergone prior cholecystectomy and therefore were excluded. Imaging consisted of gadoxetate disodium-enhanced magnetic resonance cholangiography (MRC) and multiphase contrast-enhanced CT scan of the abdomen and pelvis. Two fellowship-trained abdominal imaging radiologists, who were blinded to the MRC images and the contrast agent used during MRC, independently reviewed the CT scans of the 30 patients that were included...
November 2, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27801693/change-in-liver-imaging-reporting-and-data-system-characterization-of-focal-liver-lesions-using-gadoxetate-disodium-magnetic-resonance-imaging-compared-with-contrast-enhanced-computed-tomography
#9
Thomas A Hope, Rizwan Aslam, Stefanie Weinstein, Benjamin M Yeh, Carlos U Corvera, Alex Monto, Judy Yee
PURPOSE: The aim of this study was to determine whether gadoxetate-enhanced magnetic resonance imaging (MRI) improves lesion characterization in patients at risk for hepatocellular carcinoma compared with computed tomography (CT). MATERIALS AND METHODS: Forty-nine patients with indeterminate lesions found at contrast-enhanced CT were prospectively enrolled and imaged using gadoxetate-enhanced hepatobiliary phase (HBP) MRI within 30 days of their initial CT. Three readers graded each lesion at CT and MRI using the Liver Imaging Reporting and Data System (LI-RADS) v2014 major criteria and HBP characterization as an ancillary feature...
October 31, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27797675/intrahepatic-cholangiocarcinoma-in-patients-with-cirrhosis-differentiation-from-hepatocellular-carcinoma-by-using-gadoxetic-acid-enhanced-mr-imaging-and-dynamic-ct
#10
Sang Hyun Choi, Seung Soo Lee, So Yeon Kim, So Hyun Park, Seong Ho Park, Kang Mo Kim, Seung-Mo Hong, Eunsil Yu, Moon-Gyu Lee
Purpose To determine the imaging features at gadoxetic acid-enhanced magnetic resonance (MR) imaging of intrahepatic cholangiocarcinoma (IHCC) in a cirrhotic liver, with an emphasis on the distinction between IHCC and hepatocellular carcinoma (HCC) and on the comparison of nodule enhancement patterns between MR imaging and computed tomography (CT). Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Gadoxetic acid-enhanced MR and CT images in 72 consecutive patients (61 men; mean age, 56...
October 31, 2016: Radiology
https://www.readbyqxmd.com/read/27789027/high-flow-haemangiomas-versus-hypervascular-hepatocellular-carcinoma-showing-pseudo-washout-on-gadoxetic-acid-enhanced-hepatic-mri-value-of-diffusion-weighted-imaging-in-the-differential-diagnosis-of-small-lesions
#11
S J Nam, J-S Yu, E-S Cho, J H Kim, J-J Chung
AIM: To validate the usefulness of diffusion-weighted imaging (DWI) in the differentiation of high-flow haemangiomas showing pseudo-washout appearance on gadoxetic acid-enhanced hepatic MRI from small hypervascular hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: DWI (b=50, 800 s/mm(2)) with apparent diffusion coefficient (ADC) maps for 50 haemangiomas (6.4±2.9 mm) showing intense enhancement on arterial dominant phase imaging and hypointensity on transitional and/or hepatobiliary phase imaging during gadoxetic acid-enhanced MRI were retrospectively analysed and compared with that of 113 hypervascular HCCs (12...
October 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27780379/pre-hepatectomy-assessment-of-bile-transporter-expression-by-gadoxetic-acid-enhanced-mri-in-a-rat-model-of-liver-cirrhosis
#12
Joohyun Kim, Tae Kim, Kwan Soo Hong, Hyeyoung Moon, In-Kyung Oh, Sang Mok Lee, Mark D Hohenwalter, Michael A Zimmerman, David C Cronin, Johnny C Hong
BACKGROUND: Gadoxetic acid is a liver-specific intravenous T1 magnetic resonance (MR) contrast agent that is excreted via the hepatobiliary system. We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI). METHODS: Two groups of rats, control (n = 6) and cirrhosis (n = 12), received gadoxetic acid enhanced MRI followed by 70% hepatectomy. The change in MR signal intensity from the baseline before the contrast injection (ΔSI) was analyzed every minute for 30 min...
October 26, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27776652/biliary-tract-enhancement-in-gadoxetic-acid-enhanced-mri-correlates-with-liver-function-biomarkers
#13
Yoshifumi Noda, Satoshi Goshima, Kimihiro Kajita, Hiroshi Kawada, Nobuyuki Kawai, Hiromi Koyasu, Masayuki Matsuo, Kyongtae T Bae
PURPOSE: To evaluate the association between gadoxetic-acid-enhanced magnetic resonance (MR) imaging measurements and laboratory and clinical biomarkers of liver function and fibrosis. MATERIALS AND METHODS: One hundred thirty nine consecutive patients with suspected liver disease or liver tumor underwent gadoxetic-acid-enhanced MR imaging. MR imaging measurements during the hepatobiliary phase included biliary tract structure-to-muscle signal intensity ratio (SIR)...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27770230/added-value-of-smooth-hypointense-rim-in-the-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mri-in-identifying-tumour-capsule-and-diagnosing-hepatocellular-carcinoma
#14
Chansik An, Hyungjin Rhee, Kyunghwa Han, Jin-Young Choi, Young-Nyun Park, Mi-Suk Park, Myeong-Jin Kim, Sumi Park
OBJECTIVES: To examine the added value of considering smooth hypointense rim in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI as capsule appearance for diagnosing tumour capsules and hepatocellular carcinoma (HCC). METHODS: A total of 377 hepatic lesions (330 HCCs, 35 non-HCC malignancies and 12 benign) were included from 345 patients who underwent resection after MRI between January 2008 and December 2011. Two radiologists assessed the presence or absence of conventional capsule appearance and smooth hypointense rim in the HBP, and categorized each hepatic lesion according to the Liver Imaging Reporting and Data System...
October 21, 2016: European Radiology
https://www.readbyqxmd.com/read/27768617/performance-of-gadoxetic-acid-enhanced-liver-magnetic-resonance-imaging-for-predicting-patient-eligibility-for-liver-transplantation-based-on-the-milan-criteria
#15
Hwi Young Jang, Joon-Il Choi, Young Joon Lee, Michael Yong Park, Dong Myung Yeo, Sung Eun Rha, Eun Sun Jung, Young Kyoung You, Dong Goo Kim, Jae Young Byun
PURPOSE: This study aimed to evaluate the accuracy of gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) in predicting eligibility for liver transplantation in patients with hepatocellular carcinoma (HCC) based on Milan criteria (MC). MATERIALS AND METHODS: We reviewed Gd-EOB-MRI of 44 patients who underwent liver transplantation for HCC with cirrhosis for the presence/size of HCCs, vascular invasion, and transplant eligibility based on MC. Hepatocellular carcinoma was diagnosed based on conventional radiological hallmarks (arterial enhancement and washout) or the modified criteria...
October 20, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27755934/case-235-hepatic-adenomatosis-due-to-inflammatory-adenomas
#16
Gavin Low, Harini Dharmana, Samantha Saravana-Bawan, Safwat Girgis
History An asymptomatic 33-year-old woman was referred to the Hepatology Department in 2013 for work-up of indeterminate multifocal liver masses. These lesions were discovered incidentally at multiphase contrast material-enhanced multidetector computed tomography (CT) performed in 2004 to investigate right lower quadrant pain. Imaging surveillance at sporadic intervals revealed slow progressive growth of the lesions over time; however, the number of lesions remained constant. There was no history of cancer, nor were there predisposing factors for chronic liver disease or cirrhosis...
November 2016: Radiology
https://www.readbyqxmd.com/read/27740898/benign-hepatocellular-nodules-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mr-imaging-based-on-molecular-background
#17
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Kazuto Kozaka, Satoshi Kobayashi, Motoko Sasaki, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Toshifumi Gabata
Gadoxetic acid is a contrast agent for magnetic resonance (MR) imaging with hepatocyte-specific properties and is becoming increasingly important in detection and characterization of hepatocellular carcinoma and benign hepatocellular nodules, including focal nodular hyperplasia (FNH), nodular regenerative hyperplasia (NRH), hepatocellular adenoma (HCA), and dysplastic nodule. In these hepatocellular nodules, a positive correlation between the grade of membranous uptake transporter organic anion-transporting polypeptide (OATP) 1B3 expression and signal intensity in the hepatobiliary (HB) phase has been verified...
October 14, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27736700/transient-arterial-phase-respiratory-motion-related-artifact-in-mr-imaging-of-the-liver-an-analysis-of-four-different-gadolinium-based-contrast-agents
#18
Mansi R Shah, Milana Flusberg, Viktoriya Paroder, Alla M Rozenblit, Victoria Chernyak
PURPOSE: The purpose was to compare hepatic arterial phase (HAP) respiratory motion artifact (RMA) between gadoxetate, gadobutrol, gadopentetate, and gadobenate. MATERIALS/METHODS: Two hundred cases of each gadolinium agent were included. RMA was assigned using 5-point Likert scale (1=no motion, 5=extreme motion) on precontrast and HAP. RMA increase (increase ≥1 on HAP from precontrast) was the outcome in logistic regression. RESULTS: Odds of RMA increase for gadoxetate were 5...
September 13, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27697007/quantitative-liver-function-analysis-volumetric-t1-mapping-with-fast-multisection-b1-inhomogeneity-correction-in-hepatocyte-specific-contrast-enhanced-liver-mr-imaging
#19
Jeong Hee Yoon, Jeong Min Lee, Eunju Kim, Tomoyuki Okuaki, Joon Koo Han
Purpose To determine whether B1 inhomogeneity-corrected volumetric T1 maps of gadoxetic acid-enhanced liver magnetic resonance (MR) imaging are able to demonstrate global liver function and functional heterogeneity in patients with cirrhosis and to investigate their relationship with the development of hepatic insufficiency and decompensation. Materials and Methods This institutional review board-approved retrospective study with waiver of informed consent included 234 consecutive patients who underwent gadoxetic acid-enhanced liver MR imaging, including B1 inhomogeneity-corrected volumetric T1 mapping...
October 3, 2016: Radiology
https://www.readbyqxmd.com/read/27688063/agreement-between-region-of-interest-and-parametric-map-based-hepatic-proton-density-fat-fraction-estimation-in-adults-with-chronic-liver-disease
#20
Paul M Manning, Gavin Hamilton, Kang Wang, Chulhyun Park, Jonathan C Hooker, Tanya Wolfson, Anthony Gamst, William M Haufe, Alex N Schlein, Michael S Middleton, Claude B Sirlin
PURPOSE: To compare agreement between region-of-interest (ROI)- and parametric map-based methods of hepatic proton density fat fraction (PDFF) estimation in adults with known or suspected hepatic steatosis secondary to chronic liver disease over a range of imaging and analysis conditions. MATERIALS AND METHODS: In this IRB approved HIPAA compliant prospective single-site study, 31 adults with chronic liver disease undergoing clinical gadoxetic acid-enhanced liver magnetic resonance imaging at 3 T were recruited...
September 29, 2016: Abdominal Radiology
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