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Proton density fat fraction

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https://www.readbyqxmd.com/read/29773823/comparison-of-conventional-sonographic-signs-and-magnetic-resonance-imaging-proton-density-fat-fraction-for-assessment-of-hepatic-steatosis
#1
Mimi Kim, Bo-Kyeong Kang, Dae Won Jun
This study correlated conventional ultrasonography (US) signs with the magnetic resonance imaging (MRI) proton density fat fraction (PDFF) to evaluate the diagnostic performance of US signs (alone or combined) to predict presence and degree of hepatic steatosis (HS). Overall, 182 subjects met the study inclusion criteria between February 2014 and October 2016. Four US signs were evaluated independently by two radiologists. MRI PDFF was defined as the average of 24 non-overlapping regions of interest (ROIs) within eight liver segments obtained by drawing three ROIs within each segment...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29729148/brown-adipose-tissue-in-young-adults-who-were-born-preterm-or-small-for-gestational-age
#2
Anna Kistner, Henric Rydén, Björn Anderstam, Ann Hellström, Mikael Skorpil
BACKGROUND: Brown adipose tissue (BAT) is present and functions to dissipate energy as heat in young adults and can be assessed using magnetic resonance imaging (MRI) to estimate the voxel fat fraction, i.e. proton density fat fraction (PDFF). It is hypothesized that subjects born preterm or small for gestational age (SGA) may exhibit disrupted BAT formation coupled to metabolic factors. Our purpose was to assess the presence of BAT in young adults born extremely preterm or SGA in comparison with controls...
May 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29728744/free-breathing-quantification-of-hepatic-fat-in-healthy-children-and-children-with-nonalcoholic-fatty-liver-disease-using-a-multi-echo-3-d-stack-of-radial-mri-technique
#3
Tess Armstrong, Karrie V Ly, Smruthi Murthy, Shahnaz Ghahremani, Grace Hyun J Kim, Kara L Calkins, Holden H Wu
BACKGROUND: In adults, noninvasive chemical shift encoded Cartesian magnetic resonance imaging (MRI) and single-voxel magnetic resonance (MR) spectroscopy (SVS) accurately quantify hepatic steatosis but require breath-holding. In children, especially young and sick children, breath-holding is often limited or not feasible. Sedation can facilitate breath-holding but is highly undesirable. For these reasons, there is a need to develop free-breathing MRI technology that accurately quantifies steatosis in all children...
May 4, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29707848/assessment-of-a-high-snr-chemical-shift-encoded-mri-with-complex-reconstruction-for-proton-density-fat-fraction-pdff-estimation-overall-and-in-the-low-fat-range
#4
Charlie C Park, Catherine Hooker, Jonathan C Hooker, Emily Bass, William Haufe, Alexandra Schlein, Yesenia Covarrubias, Elhamy Heba, Mark Bydder, Tanya Wolfson, Anthony Gamst, Rohit Loomba, Jeffrey Schwimmer, Diego Hernando, Scott B Reeder, Michael Middleton, Claude B Sirlin, Gavin Hamilton
BACKGROUND: Improving the signal-to-noise ratio (SNR) of chemical-shift-encoded MRI acquisition with complex reconstruction (MRI-C) may improve the accuracy and precision of noninvasive proton density fat fraction (PDFF) quantification in patients with hepatic steatosis. PURPOSE: To assess the accuracy of high SNR (Hi-SNR) MRI-C versus standard MRI-C acquisition to estimate hepatic PDFF in adult and pediatric nonalcoholic fatty liver disease (NAFLD) using an MR spectroscopy (MRS) sequence as the reference standard...
April 29, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29705265/acetyl-coa-carboxylase-inhibitor-gs-0976-for-12-weeks-reduces-hepatic-de-novo-lipogenesis-and-steatosis-in-patients-with-nonalcoholic-steatohepatitis
#5
Eric J Lawitz, Angie Coste, Fred Poordad, Naim Alkhouri, Nicole Loo, Bryan J McColgan, Jacqueline M Tarrant, Tuan Nguyen, Ling Han, Chuhan Chung, Adrian S Ray, John G McHutchison, G Mani Subramanian, Robert P Myers, Michael S Middleton, Claude Sirlin, Rohit Loomba, Edna Nyangau, Mark Fitch, Kelvin Li, Marc Hellerstein
BACKGROUND & AIMS: Increased de novo lipogenesis (DNL) contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase catalyzes the rate-limiting step in DNL. We evaluated the safety and efficacy of GS 0976, a small molecule inhibitor of acetyl-CoA carboxylase, in patients with NASH. METHODS: In an open-label prospective study, patients with NASH (n=10) received GS-0976 20 mg orally once daily for 12 weeks. NASH was diagnosed based on a proton density fat fraction estimated by magnetic resonance imaging (MRI-PDFF) >10% and liver stiffness by magnetic resonance elastography (MRE) >2...
April 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29696666/randomised-clinical-trial-a-leucine-metformin-sildenafil-combination-ns-0200-vs-placebo-in-patients-with-non-alcoholic-fatty-liver-disease
#6
N Chalasani, R Vuppalanchi, M Rinella, M S Middleton, M S Siddiqui, A S Barritt, O Kolterman, O Flores, C Alonso, M Iruarrizaga-Lejarreta, R Gil-Redondo, C B Sirlin, M B Zemel
BACKGROUND: Sirtuin 1 (Sirt1) is suppressed in non-alcoholic fatty liver disease (NAFLD), while its' stimulation or overexpression results in reduced disease severity in pre-clinical NAFLD models. Leucine allosterically activates Sirt1 and synergise with other Sirt/AMPK/NO pathway activators. We developed a triple combination of leucine, metformin and sildenafil (NS-0200), which was effective in a mouse model of non-alcoholic steatohepatitis (NASH). AIM: To report the results from a Phase 2, randomised clinical trial of of NS-0200 in 91 subjects with NAFLD (liver fat ≥15% by magnetic resonance imaging-proton-density fat fraction (MRI-PDFF))...
April 25, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29670577/anatomical-variation-of-age-related-changes-in-vertebral-bone-marrow-composition-using-chemical-shift-encoding-based-water-fat-magnetic-resonance-imaging
#7
Thomas Baum, Alexander Rohrmeier, Jan Syväri, Maximilian N Diefenbach, Daniela Franz, Michael Dieckmeyer, Andreas Scharr, Hans Hauner, Stefan Ruschke, Jan S Kirschke, Dimitrios C Karampinos
Assessment of vertebral bone marrow composition has been proposed as imaging biomarker for osteoporosis, hematopoietic, and metabolic disorders. We investigated the anatomical variation of age-related changes of vertebral proton density fat fraction (PDFF) using chemical shift encoding-based water-fat magnetic resonance imaging (MRI). 156 healthy subjects were recruited (age range 20-29 years: 12/30 males/females; 30-39: 15/9; 40-49: 4/14; 50-59: 9/27; 60-69: 5/19; 70-79: 4/8). An eight-echo 3D spoiled gradient-echo sequence at 3T MRI was used for chemical shift-encoding based water-fat separation at the lumbar spine...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29665193/validation-of-a-motion-robust-2d-sequential-technique-for-quantification-of-hepatic-proton-density-fat-fraction-during-free-breathing
#8
B Dustin Pooler, Diego Hernando, Jeannine A Ruby, Hiroshi Ishii, Ann Shimakawa, Scott B Reeder
BACKGROUND: Current chemical-shift-encoded (CSE) MRI techniques for measuring hepatic proton density fat fraction (PDFF) are sensitive to motion artifacts. PURPOSE: Initial validation of a motion-robust 2D-sequential CSE-MRI technique for quantification of hepatic PDFF. STUDY TYPE: Phantom study and prospective in vivo cohort. POPULATION: Fifty adult patients (27 women, 23 men, mean age 57.2 years). FIELD STRENGTH/SEQUENCE: 3D, 2D-interleaved, and 2D-sequential CSE-MRI acquisitions at 1...
April 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29660324/magnetic-resonance-imaging-proton-density-fat-fraction-associates-with-progression-of-fibrosis-in-patients-with-nonalcoholic-fatty-liver-disease
#9
Veeral Ajmera, Charlie C Park, Cyrielle Caussy, Seema Singh, Carolyn Hernandez, Ricki Bettencourt, Jonathan Hooker, Ethan Sy, Cynthia Behling, Ronghui Xu, Michael S Middleton, Mark A Valasek, Claire Faulkner, Emily Rizo, Lisa Richards, Claude B Sirlin, Rohit Loomba
Markers are needed to predict progression of nonalcoholic fatty liver disease (NAFLD). The proton density fat fraction, measured by magnetic resonance imaging (MRI-PDFF), provides an accurate, validated marker of hepatic steatosis. However, it is not clear whether the proton density fat fraction identifies patients at risk for NAFLD progression. We performed a follow-up study of 95 well-characterized patients with biopsy-proven NAFLD and examined the association between liver fat content and fibrosis progression...
April 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29658780/inter-and-intraobserver-variability-of-an-anatomical-landmark-based-manual-segmentation-method-by-mri-for-the-assessment-of-skeletal-muscle-fat-content-and-area-in-subjects-from-the-general-population
#10
Lena Sophie Kiefer, Jana Fabian, Roberto Lorbeer, Jürgen Machann, Corinna Storz, Mareen Sarah Kraus, Elke Wintermeyer, Christopher L Schlett, Frank Roemer, Konstantin Nikolaou, Annette Peters, Fabian Bamberg
OBJECTIVES: Changes in skeletal muscle composition, such as fat content and mass, may exert unique metabolic and musculoskeletal risks; however, the reproducibility of their assessment is unknown. We determined the variability of the assessment of skeletal muscle fat content and area by magnetic resonance imaging (MRI) in a population-based sample. METHODS: A random sample from a prospective, community-based cohort study (KORA-FF4) was included. Skeletal muscle fat content was quantified as proton-density fat-fraction (PDFF) and area as cross-sectional area (CSA) in multi-echo Dixon sequences (TR 8...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29629807/clinical-feasibility-of-mr-elastography-in-patients-with-biliary-obstruction
#11
Dong Kyu Kim, Jin Young Choi, Mi-Suk Park, Myeong-Jin Kim, Yong Eun Chung
OBJECTIVE: The purpose of this study is to evaluate the clinical effect of liver stiffness measured using MR elastography (MRE) in patients with cholestasis due to biliary obstruction. MATERIALS AND METHODS: In this retrospective study, 69 consecutive patients with no history of diffuse liver disease who underwent pancreaticobiliary imaging with MRE were included. Quantitative MRI parameters (i.e., liver stiffness, apparent diffusion coefficient, R2*, and proton density fat fraction) and laboratory results (i...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29572891/novel-link-between-gut-microbiome-derived-metabolite-and-shared-gene-effects-with-hepatic-steatosis-and-fibrosis-in-nafld
#12
Cyrielle Caussy, Cynthia Hsu, Min-Tzu Lo, Amy Liu, Ricki Bettencourt, Veeral H Ajmera, Shirin Bassirian, Jonathan Hooker, Ethan Sy, Lisa Richards, Nicholas Schork, Bernd Schnabl, David A Brenner, Claude B Sirlin, Chi-Hua Chen, Rohit Loomba
Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease (NAFLD). We aimed to examine if serum metabolites especially those derived from the gut-microbiome have a shared gene-effect with hepatic steatosis and fibrosis. This is a cross-sectional analysis of a prospective discovery cohort including 156 well-characterized Twins and Families with untargeted metabolome profiling assessment. Hepatic steatosis was assessed using magnetic-resonance-imaging proton-density-fat-fraction (MRI-PDFF) and fibrosis using MR-elastography (MRE)...
March 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29542017/correction-to-influence-of-gd-eob-dtpa-on-proton-density-fat-fraction-using-the-six-echo-dixon-method-in-3-tesla-magnetic-resonance-imaging
#13
Tatsuya Hayashi, Kei Fukuzawa, Hiroshi Kondo, Hiroshi Onodera, Shuji Toyotaka, Rie Tojo, Shimpei Yano, Masakatsu Tano, Tosiaki Miyati, Jun'ichi Kotoku, Takahide Okamoto, Keiko Toyoda, Hiroshi Oba
A diameter of glass bottles in phantoms in the above article (2 cm) was incorrect. The correct diameter is 4.5 cm.
March 14, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29519502/ngm282-for-treatment-of-non-alcoholic-steatohepatitis-a-multicentre-randomised-double-blind-placebo-controlled-phase-2-trial
#14
Stephen A Harrison, Mary E Rinella, Manal F Abdelmalek, James F Trotter, Angelo H Paredes, Hays L Arnold, Marcelo Kugelmas, Mustafa R Bashir, Mark J Jaros, Lei Ling, Stephen J Rossi, Alex M DePaoli, Rohit Loomba
BACKGROUND: Non-alcoholic steatohepatitis is a chronic liver disease characterised by the presence of hepatic steatosis, inflammation, and hepatocellular injury, for which no Food and Drug Administration (FDA)-approved treatment exists. FGF19 is a hormone that regulates bile acid synthesis and glucose homoeostasis. We aimed to assess the safety and efficacy of NGM282, an engineered FGF19 analogue, for the treatment of non-alcoholic steatohepatitis. METHODS: In this randomised, double-blind, placebo-controlled, phase 2 study, we recruited patients aged 18-75 years with biopsy-confirmed non-alcoholic steatohepatitis as defined by the non-alcoholic steatohepatitis clinical research network histological scoring system, from hospitals and gastroenterology and liver clinics in Australia and the USA...
March 24, 2018: Lancet
https://www.readbyqxmd.com/read/29494349/phenotypic-multiorgan-involvement-of-subclinical-disease-as-quantified-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-normal-glucose-tolerance
#15
Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L Schlett, Fabian Bamberg
INTRODUCTION: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. MATERIALS AND METHODS: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement...
June 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29489596/effect-of-leptin-on-marrow-adiposity-in-ovariectomized-rabbits-assessed-by-proton-magnetic-resonance-spectroscopy
#16
Shaojun Li, Hongning Jiang, Bo Wang, Mingjun Gu, Ning Zhang, Wenwen Liang, Yu Wang
OBJECTIVE: Leptin acts to influence bone metabolism through indirect hypothalamic relay and direct peripheral pathways. Leptin enhances the differentiation of mesenchymal stem cells to the osteoblast rather than the adipocyte lineage, but the in vivo impacts of leptin on ovariectomy (OVX)-induced marrow adiposity are poorly understood. In this work, we aimed to address this question. METHODS: Forty-five female New Zealand rabbits were divided into sham + vehicle, OVX + vehicle, and OVX + leptin for 5 months...
February 27, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29476555/multiparameter-estimation-using-multi-echo-spoiled-gradient-echo-with-variable-flip-angles-and-multicontrast-compressed-sensing
#17
Daiki Tamada, Tetsuya Wakayama, Hiroshi Onishi, Utaroh Motosugi
PURPOSE: To develop multiparameter mapping including T1 , R2*, and proton density fat fraction with a single breath-hold to evaluate liver disease and liver function. METHODS: A 6-echo spoiled gradient-echo sequence with dual flip angles was used to acquire a 12-set MRI volume data set. To shorten the scan time, undersampling and multicontrast compressed-sensing reconstruction were used. The scan time was 18 seconds. R2* and proton density fat fraction mapping were achieved by using the iterative least-squares method...
February 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29448076/single-multi-echo-gre-acquisition-with-short-and-long-echo-spacing-for-simultaneous-quantitative-mapping-of-fat-fraction-b0-inhomogeneity-and-susceptibility
#18
Junmin Liu, Spencer D Christiansen, Maria Drangova
Multi-echo gradient echo (mGRE) sequences have been widely adapted in clinical and scientific practice for different purposes to their capability of performing Dixon MRI, generating multi-contrast images and extracting multi-parametric maps. This work aims to extend mGRE-based techniques for imaging whole head, where further technical developments are required due to the co-existence of fat and large B0 inhomogeneity in regions such as the skull base and neck. Specifically, bipolar mGRE data were acquired with a single sequence that contains both a short echo-spacing (ΔTE) echo train to capture water-fat and B0 phase shifts (for proton density fat-fraction (FF) and B0 mapping) and a longer ΔTE echo train (and long echo times) to capture subtle susceptibility variations and R2* information...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29425901/multicenter-multivendor-phantom-study-to-validate-proton-density-fat-fraction-and-t2-values-calculated-using-vendor-provided-6-point-dixon-methods
#19
Tatsuya Hayashi, Kei Fukuzawa, Hidekazu Yamazaki, Takashi Konno, Tosiaki Miyati, Jun'ichi Kotoku, Hiroshi Oba, Hiroshi Kondo, Keiko Toyoda, Satoshi Saitoh
PURPOSE: To evaluate the reproducibility of proton density fat fraction (PDFF) and T2* in a fat-water phantom on three different 3 T MRI systems using 6-point DIXON methods. METHODS: A phantom which included varying fat volume percentages (true fat fraction [FF]) was scanned by three 3 T MR machines, and PDFF and T2* were measured. RESULTS: The mean difference between true FF and PDFF was small in all vendors (-2.11% to 0.41%). However, the difference ratio for T2* values was large among vendors (1...
February 2, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29424449/viral-eradication-reduces-both-liver-stiffness-and-steatosis-in-patients-with-chronic-hepatitis-c-virus-infection-who-received-direct-acting-anti-viral-therapy
#20
T Tada, T Kumada, H Toyoda, Y Sone, K Takeshima, S Ogawa, T Goto, A Wakahata, M Nakashima, M Nakamuta, J Tanaka
BACKGROUND: Whether direct-acting anti-viral therapy can reduce liver fibrosis and steatosis in patients with chronic hepatitis C virus (HCV) infection is unclear. AIMS: To evaluate changes in liver stiffness and steatosis in patients with HCV who received direct-acting anti-viral therapy and achieved sustained virological response (SVR). METHODS: A total of 198 patients infected with HCV genotype 1 or 2 who achieved SVR after direct-acting anti-viral therapy were analysed...
April 2018: Alimentary Pharmacology & Therapeutics
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