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Proton density fat fraction

Tatsuya Hayashi, Kei Fukuzawa, Hiroshi Kondo, Hiroshi Onodera, Shuji Toyotaka, Rie Tojo, Shimpei Yano, Masakatsu Tano, Tosiaki Miyati, Jun'ichi Kotoku, Takahide Okamoto, Keiko Toyoda, Hiroshi Oba
A diameter of glass bottles in phantoms in the above article (2 cm) was incorrect. The correct diameter is 4.5 cm.
March 14, 2018: Radiological Physics and Technology
Stephen A Harrison, Mary E Rinella, Manal F Abdelmalek, James F Trotter, Angelo H Paredes, Hays L Arnold, Marcelo Kugelmas, Mustafa R Bashir, Mark J Jaros, Lei Ling, Stephen J Rossi, Alex M DePaoli, Rohit Loomba
BACKGROUND: Non-alcoholic steatohepatitis is a chronic liver disease characterised by the presence of hepatic steatosis, inflammation, and hepatocellular injury, for which no Food and Drug Administration (FDA)-approved treatment exists. FGF19 is a hormone that regulates bile acid synthesis and glucose homoeostasis. We aimed to assess the safety and efficacy of NGM282, an engineered FGF19 analogue, for the treatment of non-alcoholic steatohepatitis. METHODS: In this randomised, double-blind, placebo-controlled, phase 2 study, we recruited patients aged 18-75 years with biopsy-confirmed non-alcoholic steatohepatitis as defined by the non-alcoholic steatohepatitis clinical research network histological scoring system, from hospitals and gastroenterology and liver clinics in Australia and the USA...
March 5, 2018: Lancet
Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L Schlett, Fabian Bamberg
INTRODUCTION: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. MATERIALS AND METHODS: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement...
February 28, 2018: Investigative Radiology
Shaojun Li, Hongning Jiang, Bo Wang, Mingjun Gu, Ning Zhang, Wenwen Liang, Yu Wang
OBJECTIVE: Leptin acts to influence bone metabolism through indirect hypothalamic relay and direct peripheral pathways. Leptin enhances the differentiation of mesenchymal stem cells to the osteoblast rather than the adipocyte lineage, but the in vivo impacts of leptin on ovariectomy (OVX)-induced marrow adiposity are poorly understood. In this work, we aimed to address this question. METHODS: Forty-five female New Zealand rabbits were divided into sham + vehicle, OVX + vehicle, and OVX + leptin for 5 months...
February 27, 2018: Journal of Computer Assisted Tomography
Daiki Tamada, Tetsuya Wakayama, Hiroshi Onishi, Utaroh Motosugi
PURPOSE: To develop multiparameter mapping including T1 , R2*, and proton density fat fraction with a single breath-hold to evaluate liver disease and liver function. METHODS: A 6-echo spoiled gradient-echo sequence with dual flip angles was used to acquire a 12-set MRI volume data set. To shorten the scan time, undersampling and multicontrast compressed-sensing reconstruction were used. The scan time was 18 seconds. R2* and proton density fat fraction mapping were achieved by using the iterative least-squares method...
February 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Junmin Liu, Spencer D Christiansen, Maria Drangova
Multi-echo gradient echo (mGRE) sequences have been widely adapted in clinical and scientific practice for different purposes to their capability of performing Dixon MRI, generating multi-contrast images and extracting multi-parametric maps. This work aims to extend mGRE-based techniques for imaging whole head, where further technical developments are required due to the co-existence of fat and large B0 inhomogeneity in regions such as the skull base and neck. Specifically, bipolar mGRE data were acquired with a single sequence that contains both a short echo-spacing (ΔTE) echo train to capture water-fat and B0 phase shifts (for proton density fat-fraction (FF) and B0 mapping) and a longer ΔTE echo train (and long echo times) to capture subtle susceptibility variations and R2* information...
February 13, 2018: NeuroImage
Tatsuya Hayashi, Kei Fukuzawa, Hidekazu Yamazaki, Takashi Konno, Tosiaki Miyati, Jun'ichi Kotoku, Hiroshi Oba, Hiroshi Kondo, Keiko Toyoda, Satoshi Saitoh
PURPOSE: To evaluate the reproducibility of proton density fat fraction (PDFF) and T2* in a fat-water phantom on three different 3 T MRI systems using 6-point DIXON methods. METHODS: A phantom which included varying fat volume percentages (true fat fraction [FF]) was scanned by three 3 T MR machines, and PDFF and T2* were measured. RESULTS: The mean difference between true FF and PDFF was small in all vendors (-2.11% to 0.41%). However, the difference ratio for T2* values was large among vendors (1...
February 2, 2018: Clinical Imaging
T Tada, T Kumada, H Toyoda, Y Sone, K Takeshima, S Ogawa, T Goto, A Wakahata, M Nakashima, M Nakamuta, J Tanaka
BACKGROUND: Whether direct-acting anti-viral therapy can reduce liver fibrosis and steatosis in patients with chronic hepatitis C virus (HCV) infection is unclear. AIMS: To evaluate changes in liver stiffness and steatosis in patients with HCV who received direct-acting anti-viral therapy and achieved sustained virological response (SVR). METHODS: A total of 198 patients infected with HCV genotype 1 or 2 who achieved SVR after direct-acting anti-viral therapy were analysed...
February 9, 2018: Alimentary Pharmacology & Therapeutics
Janne West, Thobias Romu, Sofia Thorell, Hanna Lindblom, Emilia Berin, Anna-Clara Spetz Holm, Lotta Lindh Åstrand, Anette Karlsson, Magnus Borga, Mats Hammar, Olof Dahlqvist Leinhard
OBJECTIVES: To determine precision of magnetic resonance imaging (MRI) based fat and muscle quantification in a group of postmenopausal women. Furthermore, to extend the method to individual muscles relevant to upper-body exercise. MATERIALS AND METHODS: This was a sub-study to a randomized control trial investigating effects of resistance training to decrease hot flushes in postmenopausal women. Thirty-six women were included, mean age 56 ± 6 years. Each subject was scanned twice with a 3...
2018: PloS One
Toru Chikui, Yasuo Yamashita, Yoshitaka Kise, Tomonori Saito, Kazutoshi Okamura, Kazunori Yoshiura
OBJECTIVE: Our first objective was to prove the validity of the six-point Dixon method for estimating the proton density fat fraction (PDFF) of the salivary gland. The second objective was to estimate the salivary gland PDFF using Dixon method to evaluate the pathological conditions. METHODS: At first, 12 volunteers underwent two types of sequences: single-voxel MRS and the Dixon method and the PDFFs obtained by the two methods were compared. Next, a total of 67 individuals (normal, n=46; Sjögren's syndrome [SS], n=11; and IgG4-related dacryoadenitis and sialadenitis [IgG4-DS], n=4, parotitis, n=6) were enrolled to estimate the parotid gland (PG) and submandibular gland (SMG) PDFF using the Dixon method...
January 29, 2018: British Journal of Radiology
Thorsten Lichtenstein, Alina Sprenger, Kilian Weiss, Karin Slebocki, Barbara Cervantes, Dimitrios Karampinos, David Maintz, Gereon R Fink, Tobias D Henning, Helmar C Lehmann
Objective: To evaluate the utility of nerve diffusion tensor imaging (DTI), nerve cross-sectional area, and muscle magnetic resonance imaging (MRI) multiecho Dixon for assessing proximal nerve injury in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: In this prospective observational cohort study, 11 patients with CIDP and 11 healthy controls underwent a multiparametric MRI protocol with DTI of the sciatic nerve and assessment of muscle proton-density fat fraction of the biceps femoris and the quadriceps femoris muscles by multiecho Dixon MRI...
January 2018: Annals of Clinical and Translational Neurology
Cyrielle Caussy, Scott B Reeder, Claude B Sirlin, Rohit Loomba
Nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver transplant. Despite intensive investigations, there are currently no FDA approved therapies for treating NASH. A major barrier for drug development in NASH is that treatment response assessment continues to require liver biopsy, which is invasive and interpreted subjectively...
January 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
H J Qu, L Wang, P H Jin, Q Gao, J X Zhou, Y Song, J Wang, Y M Jiang, L Gong, G Y Chen, J P Ding, J P Shi
Objective: To investigate the value of 1H-magnetic resonance spectroscopy ((1)H-MRS) in determining the content of liver triglyceride in patients with fatty liver disease (FLD), as well as its influencing factors. Methods: A total of 124 patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis B (CHB), or hepatitis B complicated by FLD who underwent liver biopsy in the Affiliated Hospital of Hangzhou Normal University were enrolled, and the clinical data, serological markers, FibroScan results, and (1)H-MRS results were collected...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Nathan T Roberts, Diego Hernando, James H Holmes, Curtis N Wiens, Scott B Reeder
PURPOSE: The purpose of this work is to characterize the noise distribution of proton density fat fraction (PDFF) measured using chemical shift-encoded MRI, and to provide alternative strategies to reduce bias in PDFF estimation. THEORY: We derived the probability density function for PDFF estimated using chemical shift-encoded MRI, and found it to exhibit an asymmetric noise distribution that contributes to signal-to-noise-ratio dependent bias. METHODS: To study PDFF noise bias, we performed (at 1...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Frederic Carsten Schmeel, Julian Alexander Luetkens, Peter Johannes Wagenhäuser, Michael Meier-Schroers, Daniel Lloyd Kuetting, Andreas Feißt, Jürgen Gieseke, Leonard Christopher Schmeel, Frank Träber, Hans Heinz Schild, Guido Matthias Kukuk
OBJECTIVES: To investigate whether proton density fat fraction (PDFF) measurements using a six-echo modified Dixon sequence can help to differentiate between benign and malignant vertebral bone marrow lesions. METHODS: Sixty-six patients were prospectively enrolled in our study. In addition to conventional MRI at 3.0-Tesla including at least sagittal T2-weighted/spectral attenuated inversion recovery and T1-weighted sequences, all patients underwent a sagittal six-echo modified Dixon sequence of the spine...
January 8, 2018: European Radiology
Giacomo Germani, Chiara Becchetti
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MS) [1], and it is defined by the presence of steatosis in >5% of hepatocytes, according to histological analysis or detected by specific proton density fat fraction obtained MRI. The term NAFLD covers two pathologically distinct conditions: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), which can have similar clinical presentation, but with different prognosis. Both conditions can lastly lead to the development of cirrhosis...
December 15, 2017: Minerva Gastroenterologica e Dietologica
Li Xu, Yangyang Duanmu, Glen M Blake, Chenxin Zhang, Yong Zhang, Keenan Brown, Xiaoqi Wang, Peng Wang, Xingang Zhou, Manling Zhang, Chao Wang, Zhe Guo, Giuseppe Guglielmi, Xiaoguang Cheng
OBJECTIVES: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. METHODS: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical measurement and histology...
December 13, 2017: European Radiology
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
April 2018: Surgical Endoscopy
Tyler J Fraum, Daniel R Ludwig, Scott Kilian, William A Curtis, Thomas K Pilgram, Claude B Sirlin, Kathryn J Fowler
RATIONALE AND OBJECTIVES: Little is known about the frequency and risk factors of hepatic steatosis in the tertiary care setting. Such knowledge is essential to clinicians making decisions about testing for this condition. Thus, our aim was to describe the epidemiology of hepatic steatosis, as captured by magnetic resonance imaging (MRI), at a tertiary care center. MATERIALS AND METHODS: A near-consecutive cohort of 1006 adult patients underwent standard-of-care liver MRIs...
March 2018: Academic Radiology
Cheng William Hong, Soudabeh Fazeli Dehkordy, Jonathan C Hooker, Gavin Hamilton, Claude B Sirlin
Fatty liver disease is characterized histologically by hepatic steatosis, the abnormal accumulation of lipid in hepatocytes. It is classified into alcoholic fatty liver disease and nonalcoholic fatty liver disease, and is an increasingly important cause of chronic liver disease and cirrhosis. Assessing the severity of hepatic steatosis in these conditions is important for diagnostic and prognostic purposes, as hepatic steatosis is potentially reversible if diagnosed early. The criterion standard for assessing hepatic steatosis is liver biopsy, which is limited by sampling error, its invasive nature, and associated morbidity...
December 2017: Topics in Magnetic Resonance Imaging: TMRI
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