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Proton density fat fraction

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https://www.readbyqxmd.com/read/28110367/accurate-simultaneous-quantification-of-liver-steatosis-and-iron-overload-in-diffuse-liver-diseases-with-mri
#1
Manuela França, Ángel Alberich-Bayarri, Luis Martí-Bonmatí, Pedro Oliveira, Francisca Emanuel Costa, Graça Porto, José Ramón Vizcaíno, Javier Sanchez Gonzalez, Eduardo Ribeiro, João Oliveira, Helena Pessegueiro Miranda
PURPOSE: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload in a wide spectrum of diffuse liver diseases having biopsy as reference standard. METHODS: MECSE-MR-acquired images were used to calculate fat fraction and iron content in a single breath-hold in 109 adult patients. Proton density fat fraction (PDFF) was prospectively estimated using complex-based data reconstruction with multipeak fat modeling...
January 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28063601/bone-marrow-fat-content-is-correlated-with-hepatic-fat-content-in-paediatric-non-alcoholic-fatty-liver-disease
#2
N Y Yu, T Wolfson, M S Middleton, G Hamilton, A Gamst, J E Angeles, J B Schwimmer, C B Sirlin
AIM: To investigate the relationship between bone marrow fat content and hepatic fat content in children with known or suspected non-alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: This was an institutional review board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant, cross-sectional, prospective analysis of data collected between October 2010 to March 2013 in 125 children with known or suspected NAFLD. Written informed consent was obtained for same-day research magnetic resonance imaging (MRI) of the lumbar spine, liver, and abdominal adiposity...
January 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28028556/effect-of-intravenous-gadoxetate-disodium-and-flip-angle-on-hepatic-proton-density-fat-fraction-estimation-with-six-echo-gradient-recalled-echo-magnitude-based-mr-imaging-at-3t
#3
Charlie C Park, Gavin Hamilton, Ajinkya Desai, Kevin A Zand, Tanya Wolfson, Jonathan C Hooker, Eduardo Costa, Elhamy Heba, Lisa Clark, Anthony Gamst, Rohit Loomba, Michael S Middleton, Claude B Sirlin
PURPOSE: The aim of the study was to determine in patients undergoing gadoxetate disodium (Gx)-enhanced MR exams whether proton density fat fraction (PDFF) estimation accuracy of magnitude-based multi-gradient-echo MRI (MRI-M) could be improved by using high flip angle (FA) on post-contrast images. MATERIALS AND METHODS: Thirty-one adults with known or suspected hepatic steatosis undergoing 3T clinical Gx-enhanced liver MRI were enrolled prospectively. MR spectroscopy (MRS), the reference standard, was performed before Gx to measure MRS-PDFF...
December 28, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/28027736/proton-density-fat-fraction-measurement-a-viable-quantitative-biomarker-for-differentiating-adrenal-adenomas-from-nonadenomas
#4
Xiaoyan Meng, Xiao Chen, Yaqi Shen, Xuemei Hu, Hao Tang, Daoyu Hu, Zhen Li, Ihab R Kamel
PURPOSE: This study aims to compare the accuracy of proton-density fat fraction (PDFF) measurements with chemical shift magnetic resonance imaging (CSI) for quantifying the fat content of adrenal nodules and for differentiating adenomas from nonadenomas. MATERIALS AND METHODS: Oil-saline phantom measurements was performed to compare the correlation between PDFF and CSI in detecting and quantifying fat content. 43 consecutive patients who had known adrenal nodules were imaged on a 3...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27999110/subclinical-disease-burden-as-assessed-by-whole-body-mri-in-subjects-with-prediabetes-subjects-with-diabetes-and-normal-control-subjects-from-the-general-population-the-kora-mri-study
#5
Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D Auweter, Christopher L Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian F Reiser, Annette Peters
Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat)...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27986169/hepatic-steatosis-etiology-patterns-and-quantification
#6
Ilkay S Idilman, Ilknur Ozdeniz, Musturay Karcaaltincaba
Hepatic steatosis can occur because of nonalcoholic fatty liver disease (NAFLD), alcoholism, chemotherapy, and metabolic, toxic, and infectious causes. Pediatric hepatic steatosis is also becoming more frequent and can have distinctive features. The most common pattern is diffuse form; however, it can present in heterogenous, focal, multinodular, perilesional, perivascular, subcapsular, and lobar forms. Focal steatosis and fat sparing can occur because of the presence of veins of Sappey, pancreaticoduodenal vein, and aberrant right and left gastric veins, which drain into the liver as third inflow...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27937040/multiparametric-or-practical-quantitative-liver-mri-towards-millisecond-fat-fraction-kilopascal-and-function-era
#7
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27911262/magnetic-resonance-elastography-vs-transient-elastography-in-detection-of-fibrosis-and-noninvasive-measurement-of-steatosis-in-patients-with-biopsy-proven-nonalcoholic-fatty-liver-disease
#8
Charlie C Park, Phirum Nguyen, Carolyn Hernandez, Ricki Bettencourt, Kimberly Ramirez, Lynda Fortney, Jonathan Hooker, Ethan Sy, Michael T Savides, Mosab H Alquiraish, Mark A Valasek, Emily Rizo, Lisa Richards, David Brenner, Claude B Sirlin, Rohit Loomba
BACKGROUND & AIMS: Magnetic resonance imaging (MRI) techniques and ultrasound-based transient elastography (TE) can be used in noninvasive diagnosis of fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD). We performed a prospective study to compare the performance of magnetic resonance elastography (MRE) vs TE for diagnosis of fibrosis, and MRI-based proton density fat fraction (MRI-PDFF) analysis vs TE-based controlled attenuation parameter (CAP) for diagnosis of steatosis in patients undergoing biopsy to assess NAFLD...
October 27, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27851874/adc-quantification-of-the-vertebral-bone-marrow-water-component-removing-the-confounding-effect-of-residual-fat
#9
Michael Dieckmeyer, Stefan Ruschke, Holger Eggers, Hendrik Kooijman, Ernst J Rummeny, Jan S Kirschke, Thomas Baum, Dimitrios C Karampinos
PURPOSE: To remove the confounding effect of unsuppressed fat on the imaging-based apparent diffusion coefficient (ADC) of the vertebral bone marrow water component when using spectrally selective fat suppression and to compare and validate the proposed quantification strategy against diffusion-weighted magnetic resonance spectroscopy (DW-MRS). METHODS: Twelve subjects underwent diffusion-weighted imaging (DWI) and DW-MRS of the vertebral bone marrow. A theoretical model was developed to take into account and correct the effects of residual fat on ADC, incorporating additional measurements for proton density fat fraction (PDFF) and water T2 (T2w)...
November 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27824667/proton-magnetic-resonance-spectroscopy-detected-changes-of-marrow-fat-content-in-a-rabbit-model-of-osteoporosis-treated-with-epigallocatechin-3-gallate
#10
Yin Liu, Sijie Wu, Rongrong Cui, Qian Chan, Shengwang Zhang, Yunjie Liao, Can Huang
OBJECTIVE: The aim of this study was to longitudinally evaluate the changes in marrow fat content of ovariectomized (OVX) rabbits treated with epigallocatechin-3-gallate (EGCG) using proton magnetic resonance spectroscopy (H-MRS). METHODS: Thirty-six female New Zealand rabbits were equally divided into sham operation, OVX controls, and OVX treated with EGCG (intraperitoneally, 1.8 mg/kg) for 5 months. Marrow fat fraction by H-MRS and bone density by peripheral quantitative computed tomography were determined at 0, 3, and 5 months...
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27818597/comparison-of-magnetic-resonance-spectroscopy-proton-density-fat-fraction-and-histological-analysis-in-the-quantification-of-liver-steatosis-in-children-and-adolescents
#11
Michele Di Martino, Lucia Pacifico, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Claudio Chiesa, Carlo Catalano
AIM: To establish a threshold value for liver fat content between healthy children and those with non-alcoholic fatty liver disease (NAFLD) by using magnetic resonance imaging (MRI), with liver biopsy serving as a reference standard. METHODS: The study was approved by the local ethics committee, and written informed consent was obtained from all participants and their legal guardians before the study began. Twenty-seven children with NAFLD underwent liver biopsy to assess the presence of nonalcoholic steatohepatitis...
October 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27797100/correction-of-phase-errors-in-quantitative-water-fat-imaging-using-a-monopolar-time-interleaved-multi-echo-gradient-echo-sequence
#12
Stefan Ruschke, Holger Eggers, Hendrik Kooijman, Maximilian N Diefenbach, Thomas Baum, Axel Haase, Ernst J Rummeny, Houchun H Hu, Dimitrios C Karampinos
PURPOSE: To propose a phase error correction scheme for monopolar time-interleaved multi-echo gradient echo water-fat imaging that allows accurate and robust complex-based quantification of the proton density fat fraction (PDFF). METHODS: A three-step phase correction scheme is proposed to address a) a phase term induced by echo misalignments that can be measured with a reference scan using reversed readout polarity, b) a phase term induced by the concomitant gradient field that can be predicted from the gradient waveforms, and c) a phase offset between time-interleaved echo trains...
October 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27783208/non-invasive-diagnosis-of-hepatic-steatosis
#13
REVIEW
Christiane Stern, Laurent Castera
Non-invasive diagnosis and quantification of hepatic steatosis rely on two different but complementary approaches: biomarkers or imaging techniques, either ultrasound-based such as liver ultrasonography and controlled attenuation parameter (CAP), or computed tomography (CT) and magnetic resonance imaging (MRI). Scores for the detection of steatosis have not gained much popularity in clinical practice so far. CAP, using the M probe, is the most promising technique but needs to be implemented with the XL probe and compared to ultrasound that, despite its limitations, remains the most widely used method...
October 25, 2016: Hepatology International
https://www.readbyqxmd.com/read/27726414/accuracy-of-liver-fat-quantification-with-advanced-ct-mri-and-ultrasound-techniques-prospective-comparison-with-mr-spectroscopy
#14
Harald Kramer, Perry J Pickhardt, Mark A Kliewer, Diego Hernando, Guang-Hong Chen, James A Zagzebski, Scott B Reeder
OBJECTIVE: The purpose of this study was to prospectively evaluate the accuracy of proton-density fat-fraction, single- and dual-energy CT (SECT and DECT), gray-scale ultrasound (US), and US shear-wave elastography (US-SWE) in the quantification of hepatic steatosis with MR spectroscopy (MRS) as the reference standard. SUBJECTS AND METHODS: Fifty adults who did not have symptoms (23 men, 27 women; mean age, 57 ± 5 years; body mass index, 27 ± 5) underwent liver imaging with un-enhanced SECT, DECT, gray-scale US, US-SWE, proton-density fat-fraction MRI, and MRS for this prospective trial...
January 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27688063/agreement-between-region-of-interest-and-parametric-map-based-hepatic-proton-density-fat-fraction-estimation-in-adults-with-chronic-liver-disease
#15
Paul M Manning, Gavin Hamilton, Kang Wang, Chulhyun Park, Jonathan C Hooker, Tanya Wolfson, Anthony Gamst, William M Haufe, Alex N Schlein, Michael S Middleton, Claude B Sirlin
PURPOSE: To compare agreement between region-of-interest (ROI)- and parametric map-based methods of hepatic proton density fat fraction (PDFF) estimation in adults with known or suspected hepatic steatosis secondary to chronic liver disease over a range of imaging and analysis conditions. MATERIALS AND METHODS: In this IRB approved HIPAA compliant prospective single-site study, 31 adults with chronic liver disease undergoing clinical gadoxetic acid-enhanced liver magnetic resonance imaging at 3 T were recruited...
September 29, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27650137/the-effects-of-concomitant-gradients-on-chemical-shift-encoded-mri
#16
Timothy J Colgan, Diego Hernando, Samir D Sharma, Scott B Reeder
PURPOSE: The purpose of this work was to characterize the effects of concomitant gradients (CGs) on chemical shift encoded (CSE)-based estimation of B0 field map, proton density fat fraction (PDFF), and R2*. THEORY: A theoretical framework was used to determine the effects of CG-induced phase errors on CSE-MRI data. METHODS: Simulations, phantom experiments, and in vivo experiments were conducted at 3 Tesla to assess the effects of CGs on quantitative CSE-MRI techniques...
September 21, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27582882/association-of-noninvasive-quantitative-decline-in-liver-fat-content-on-mri-with-histologic-response-in-nonalcoholic-steatohepatitis
#17
Janki Patel, Ricki Bettencourt, Jeffrey Cui, Joanie Salotti, Jonathan Hooker, Archana Bhatt, Carolyn Hernandez, Phirum Nguyen, Hamed Aryafar, Mark Valasek, William Haufe, Catherine Hooker, Lisa Richards, Claude B Sirlin, Rohit Loomba
BACKGROUND: Magnetic resonance imaging-estimated proton-density-fat-fraction (MRI-PDFF) has been shown to be a noninvasive, accurate and reproducible imaging-based biomarker for assessing steatosis and treatment response in nonalcoholic steatohepatitis (NASH) clinical trials. However, there are no data on the magnitude of MRI-PDFF reduction corresponding to histologic response in the setting of a NASH clinical trial. The aim of this study was to quantitatively compare the magnitude of MRI-PDFF reduction between histologic responders versus histologic nonresponders in NASH patients...
September 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27541685/reduction-of-longitudinal-vertebral-blood-perfusion-and-its-likely-causes-a-quantitative-dynamic-contrast-enhanced-mr-imaging-study-of-a-rat-osteoporosis-model
#18
Jingqi Zhu, Lin Zhang, Xing Wu, Zuogang Xiong, Yuyou Qiu, Ting Hua, Guangyu Tang
Purpose To determine the longitudinal relationships among lumbar vertebral blood perfusion, bone mass, and marrow adipose tissue in a rat osteoporosis model after ovariectomy by using quantitative dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging, microcomputed tomography (micro-CT), and proton MR spectroscopy. Materials and Methods In this animal review committee-approved study, lumbar vertebrae were evaluated through MR spectroscopy, quantitative DCE MR imaging, micro-CT, and histopathologic analysis, and blood was examined at 0, 2, 6, 10, 14, 18, and 24 weeks after ovariectomy consisting of exposure of the ovaries but no excision (n = 35) or sham operation, defined as exposure of the ovaries but no excision (n = 35)...
February 2017: Radiology
https://www.readbyqxmd.com/read/27405703/quantification-of-liver-fat-in-the-presence-of-iron-overload
#19
Debra E Horng, Diego Hernando, Scott B Reeder
PURPOSE: To evaluate the accuracy of R2* models (1/T2 * = R2*) for chemical shift-encoded magnetic resonance imaging (CSE-MRI)-based proton density fat-fraction (PDFF) quantification in patients with fatty liver and iron overload, using MR spectroscopy (MRS) as the reference standard. MATERIALS AND METHODS: Two Monte Carlo simulations were implemented to compare the root-mean-squared-error (RMSE) performance of single-R2* and dual-R2* correction in a theoretical liver environment with high iron...
July 13, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27341545/comparison-of-chemical-shift-encoded-water-fat-mri-and-mr-spectroscopy-in-quantification-of-marrow-fat-in-postmenopausal-females
#20
Guanwu Li, Zheng Xu, Hao Gu, Xuefeng Li, Wei Yuan, Shixin Chang, Jingzheng Fan, Horea Calimente, Jiani Hu
PURPOSE: To validate a chemical shift-encoded (CSE) water-fat imaging for quantifying marrow fat fraction (FF), using proton magnetic resonance spectroscopy (MRS) as reference. MATERIALS AND METHODS: Multiecho T2 -corrected MRS and CSE imaging with eight-echo gradient-echo acquisitions at 3T were performed to calculate marrow FF in 83 subjects, including 41 with normal bone mineral density (BMD), 26 with osteopenia, and 16 with osteoporosis (based on DXA). Eight participants were scanned three times with repositioning to assess the repeatability of CSE FF map measurements...
January 2017: Journal of Magnetic Resonance Imaging: JMRI
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