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Proton density fat fraction

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https://www.readbyqxmd.com/read/28520813/pancreatic-fat-content-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-controls-from-a-general-population-without-cardiovascular-disease
#1
Sophia D Heber, Holger Hetterich, Roberto Lorbeer, Christian Bayerl, Jürgen Machann, Sigrid Auweter, Corinna Storz, Christopher L Schlett, Konstantin Nikolaou, Maximilian Reiser, Annette Peters, Fabian Bamberg
BACKGROUND/OBJECTIVE: Despite the relevance of pancreatic fat content in the development of metabolic diseases, its association with impaired glucose metabolism, diabetes, and other adipose tissue compartments remains unclear. Thus, we determined differences in pancreatic fat content by magnetic resonance imaging (MRI) between subjects with prediabetes, diabetes, and normal controls in a cohort from the general population. METHODS: Subjects without history of cardiovascular disease with established diabetes or prediabetes as well as normal controls were included and underwent whole-body MRI on a 3T scanner...
2017: PloS One
https://www.readbyqxmd.com/read/28505623/effect-of-a-low-rank-denoising-algorithm-on-quantitative-magnetic-resonance-imaging-based-measures-of-liver-fat-and-iron
#2
Brian C Allen, Felix Lugauer, Dominik Nickel, Lubna Bhatti, Randa A Dafalla, Brian M Dale, Tracy A Jaffe, Mustafa R Bashir
PURPOSE: This study aimed to assess the effect of a low-rank denoising algorithm on quantitative magnetic resonance imaging-based measures of liver fat and iron. MATERIALS AND METHODS: This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant, retrospective analysis of 42 consecutive subjects who were imaged at 3T using a multiecho gradient echo sequence that was reconstructed using the multistep adaptive fitting algorithm to obtain quantitative proton density fat fraction (PDFF) and R2* maps (original maps)...
May 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28481195/prevalence-of-fatty-liver-disease-and-hepatic-iron-overload-in-a-northeastern-german-population-by-using-quantitative-mr-imaging
#3
Jens-Peter Kühn, Peter Meffert, Christian Heske, Marie-Luise Kromrey, Carsten O Schmidt, Birger Mensel, Henry Völzke, Markus M Lerch, Diego Hernando, Julia Mayerle, Scott B Reeder
Purpose To quantify liver fat and liver iron content by measurement of confounder-corrected proton density fat fraction (PDFF) and R2* and to identify clinical associations for fatty liver disease and liver iron overload and their prevalence in a large-scale population-based study. Materials and Methods From 2008 to 2013, 2561 white participants (1336 women; median age, 52 years; 25th and 75th quartiles, 42 and 62 years) were prospectively recruited to the Study of Health in Pomerania (SHIP). Complex chemical shift-encoded magnetic resonance (MR) examination of the liver was performed, from which PDFF and R2* were assessed...
May 5, 2017: Radiology
https://www.readbyqxmd.com/read/28460192/proton-density-fat-fraction-of-rotator-cuff-muscles-is-associated-with-isometric-strength-10-years-after-rotator-cuff-repair-a-quantitative-magnetic-resonance-imaging-study-of-the-shoulder
#4
Dimitrios C Karampinos, Christian Holwein, Stefan Buchmann, Thomas Baum, Stefan Ruschke, Alexandra S Gersing, Reto Sutter, Andreas B Imhoff, Ernst J Rummeny, Pia M Jungmann
BACKGROUND: Quantitative muscle fat-fraction magnetic resonance (MR) imaging techniques correlate with semiquantitative Goutallier scores with failure after rotator cuff (RC) repair. PURPOSE: To investigate the relationship of proton density fat fraction (PDFF) of the RC muscles with semiquantitative MR scores, cartilage T2 relaxation times, and clinical isometric strength measurements in patients 10 years after unilateral RC repair. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28442120/american-gastroenterological-association-institute-technical-review-on-the-role-of-elastography-in-chronic-liver-diseases
#5
Siddharth Singh, Andrew J Muir, Douglas T Dieterich, Yngve T Falck-Ytter
Chronic liver diseases (CLDs), due to chronic hepatitis C; hepatitis B; nonalcoholic fatty liver diseases (NAFLD); and alcoholic liver disease, are a leading cause of morbidity and mortality globally. Early identification of patients with cirrhosis at high risk of progression to liver-related complications may facilitate timely care and improve outcomes. With risks and misclassification associated with invasive tests, such as liver biopsy, noninvasive imaging modalities for liver fibrosis assessment have gained popularity...
May 2017: Gastroenterology
https://www.readbyqxmd.com/read/28432403/bone-marrow-fat-content-in-70-adolescent-girls-with-anorexia-nervosa-magnetic-resonance-imaging-and-magnetic-resonance-spectroscopy-assessment
#6
Kirsten Ecklund, Sridhar Vajapeyam, Robert V Mulkern, Henry A Feldman, Jennifer M O'Donnell, Amy D DiVasta, Catherine M Gordon
BACKGROUND: Adolescents and women with anorexia nervosa have increased bone marrow fat and decreased bone formation, at least in part due to hormonal changes leading to preferential stem cell differentiation to adipocytes over osteoblasts. OBJECTIVE: The purpose of this study was to evaluate marrow fat content and correlate with age and disease severity using knee MRI with T1 relaxometry (T1-R) and MR spectroscopy (MRS) in 70 adolescents with anorexia nervosa. MATERIALS AND METHODS: We enrolled 70 girls with anorexia nervosa who underwent 3-T knee MRI with coronal T1-W images, T1-R and single-voxel proton MRS at 30 and 60 ms TE...
April 22, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28419582/free-breathing-liver-fat-quantification-using-a-multiecho-3d-stack-of-radial-technique
#7
Tess Armstrong, Isabel Dregely, Alto Stemmer, Fei Han, Yutaka Natsuaki, Kyunghyun Sung, Holden H Wu
PURPOSE: The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, a novel free-breathing 3D stack-of-radial (FB radial) liver fat quantification technique is developed and evaluated in a preliminary study. METHODS: Phantoms and healthy subjects (n = 11) were imaged at 3 Tesla. The proton-density fat fraction (PDFF) determined using FB radial (with and without scan acceleration) was compared to BH single-voxel MR spectroscopy (SVS) and BH 3D Cartesian MRI using linear regression (correlation coefficient ρ and concordance coefficient ρc ) and Bland-Altman analysis...
April 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28382554/measurement-of-vertebral-bone-marrow-proton-density-fat-fraction-in-children-using-quantitative-water-fat-mri
#8
Stefan Ruschke, Amber Pokorney, Thomas Baum, Holger Eggers, Jeffrey H Miller, Houchun H Hu, Dimitrios C Karampinos
OBJECTIVES: To investigate the feasibility of employing a 3D time-interleaved multi-echo gradient-echo (TIMGRE) sequence to measure the proton density fat fraction (PDFF) in the vertebral bone marrow (VBM) of children and to examine cross-sectional changes with age and intra-individual variations from the lumbar to the cervical region in the first two decades of life. MATERIALS AND METHODS: Quantitative water-fat imaging of the spine was performed in 93 patients (49 girls; 44 boys; age median 4...
April 5, 2017: Magma
https://www.readbyqxmd.com/read/28332039/combined-quantification-of-fatty-infiltration-t-1-relaxation-times-and-t-2-relaxation-times-in-normal-appearing-skeletal-muscle-of-controls-and-dystrophic-patients
#9
Benjamin Leporq, Arnaud Le Troter, Yann Le Fur, Emmanuelle Salort-Campana, Maxime Guye, Olivier Beuf, Shahram Attarian, David Bendahan
OBJECTIVES: To evaluate the combination of a fat-water separation method with an automated segmentation algorithm to quantify the intermuscular fatty-infiltrated fraction, the relaxation times, and the microscopic fatty infiltration in the normal-appearing muscle. MATERIALS AND METHODS: MR acquisitions were performed at 1.5T in seven patients with facio-scapulo-humeral dystrophy and eight controls. Disease severity was assessed using commonly used scales for the upper and lower limbs...
March 22, 2017: Magma
https://www.readbyqxmd.com/read/28323377/accuracy-of-pdff-estimation-by-magnitude-based-and-complex-based-mri-in-children-with-mr-spectroscopy-as-a-reference
#10
William M Haufe, Tanya Wolfson, Catherine A Hooker, Jonathan C Hooker, Yesenia Covarrubias, Alex N Schlein, Gavin Hamilton, Michael S Middleton, Jorge E Angeles, Diego Hernando, Scott B Reeder, Jeffrey B Schwimmer, Claude B Sirlin
PURPOSE: To assess and compare the accuracy of magnitude-based magnetic resonance imaging (MRI-M) and complex-based MRI (MRI-C) for estimating hepatic proton density fat fraction (PDFF) in children, using MR spectroscopy (MRS) as the reference standard. A secondary aim was to assess the agreement between MRI-M and MRI-C. MATERIALS AND METHODS: This was a HIPAA-compliant, retrospective analysis of data collected in children enrolled in prospective, Institutional Review Board (IRB)-approved studies between 2012 and 2014...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28286210/using-a-3-proton-density-fat-fraction-as-a-cut-off-value-increases-sensitivity-of-detection-of-hepatic-steatosis-based-on-results-from-histopathology-analysis
#11
Patrik Nasr, Mikael F Forsgren, Simone Ignatova, Nils Dahlström, Gunnar Cedersund, Olof Dahlqvist Leinhard, Bengt Norén, Mattias Ekstedt, Peter Lundberg, Stergios Kechagias
It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy ((1)H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by magnetic resonance was derived from studies that did not use histopathology as the reference standard. We performed a prospective study to determine the accuracy of (1)H-MRS PDFF in measurement of steatosis using histopathology analysis as the standard...
March 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28278002/quantifying-abdominal-adipose-tissue-and-thigh-muscle-volume-and-hepatic-proton-density-fat-fraction-repeatability-and-accuracy-of-an-mr-imaging-based-semiautomated-analysis-method
#12
Michael S Middleton, William Haufe, Jonathan Hooker, Magnus Borga, Olof Dahlqvist Leinhard, Thobias Romu, Patrik Tunón, Gavin Hamilton, Tanya Wolfson, Anthony Gamst, Rohit Loomba, Claude B Sirlin
Purpose To determine the repeatability and accuracy of a commercially available magnetic resonance (MR) imaging-based, semiautomated method to quantify abdominal adipose tissue and thigh muscle volume and hepatic proton density fat fraction (PDFF). Materials and Methods This prospective study was institutional review board- approved and HIPAA compliant. All subjects provided written informed consent. Inclusion criteria were age of 18 years or older and willingness to participate. The exclusion criterion was contraindication to MR imaging...
May 2017: Radiology
https://www.readbyqxmd.com/read/28267360/a-pilot-comparative-study-of-quantitative-ultrasound-conventional-ultrasound-and-mri-for-predicting-histology-determined-steatosis-grade-in-adult-nonalcoholic-fatty-liver-disease
#13
Jeremy S Paige, Gregory S Bernstein, Elhamy Heba, Eduardo A C Costa, Marilia Fereirra, Tanya Wolfson, Anthony C Gamst, Mark A Valasek, Grace Y Lin, Aiguo Han, John W Erdman, William D O'Brien, Michael P Andre, Rohit Loomba, Claude B Sirlin
OBJECTIVE: The purpose of this study is to explore the diagnostic performance of two investigational quantitative ultrasound (QUS) parameters, attenuation coefficient and backscatter coefficient, in comparison with conventional ultrasound (CUS) and MRI-estimated proton density fat fraction (PDFF) for predicting histology-confirmed steatosis grade in adults with nonalcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS: In this prospectively designed pilot study, 61 adults with histology-confirmed NAFLD were enrolled from September 2012 to February 2014...
May 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28241076/characterisation-of-liver-fat-in-the-uk-biobank-cohort
#14
Henry R Wilman, Matt Kelly, Steve Garratt, Paul M Matthews, Matteo Milanesi, Amy Herlihy, Micheal Gyngell, Stefan Neubauer, Jimmy D Bell, Rajarshi Banerjee, E Louise Thomas
Non-alcoholic fatty liver disease and the risk of progression to steatohepatitis, cirrhosis and hepatocellular carcinoma have been identified as major public health concerns. We have demonstrated the feasibility and potential value of measuring liver fat content by magnetic resonance imaging (MRI) in a large population in this study of 4,949 participants (aged 45-73 years) in the UK Biobank imaging enhancement. Despite requirements for only a single (≤3min) scan of each subject, liver fat was able to be measured as the MRI proton density fat fraction (PDFF) with an overall success rate of 96...
2017: PloS One
https://www.readbyqxmd.com/read/28225576/3d-multiecho-dixon-for-the-evaluation-of-hepatic-iron-and-fat-in-a-clinical-setting
#15
Benjamin Henninger, Heinz Zoller, Stephan Kannengiesser, Xiaodong Zhong, Werner Jaschke, Christian Kremser
PURPOSE: To prospectively evaluate a new 3D-multiecho-Dixon (3D-ME-Dixon) sequence for the quantification of hepatic iron and fat in a clinical setting. MATERIALS AND METHODS: In all, 120 patients underwent 1.5T magnetic resonance imaging of the liver between December 2013 and June 2015 including the following three sequences: 3D-ME-Dixon with inline calculation of R2* and proton-density fat-fraction (PDFF) maps, single-voxel-spectroscopy (SVS), 2D multigradient-echo sequence (2D-ME-GRE)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225357/robust-sound-speed-estimation-for-ultrasound-based-hepatic-steatosis-assessment
#16
Marion Imbault, Alex Faccinetto, Bruno-Félix Osmanski, Antoine Tissier, Thomas Deffieux, Jean-Luc Gennisson, Valérie Vilgrain, Mickaël Tanter
Hepatic steatosis is a common condition, the prevalence of which is increasing along with non-alcoholic fatty liver disease (NAFLD). Currently, the most accurate noninvasive imaging method for diagnosing and quantifying hepatic steatosis is MRI, which estimates the proton-density fat fraction (PDFF) as a measure of fractional fat content. However, MRI suffers several limitations including cost, contra-indications and poor availability. Although conventional ultrasound is widely used by radiologists for hepatic steatosis assessment, it remains qualitative and operator dependent...
February 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28212052/proton-density-fat-fraction-measurements-at-1-5-and-3-t-hepatic-mr-imaging-same-day-agreement-among-readers-and-across-two-imager-manufacturers
#17
Suraj D Serai, Jonathan R Dillman, Andrew T Trout
Purpose To determine the agreement of proton density fat fraction (PDFF) measurements obtained with hepatic magnetic resonance (MR) imaging among readers, imager manufacturers, and field strengths. Materials and Methods This HIPAA-compliant study was approved by the institutional review board. After providing informed consent, 24 adult volunteers underwent imaging with one 1.5-T MR unit (Ingenia; Philips Healthcare, Best, the Netherlands) and two different 3.0-T units (750 W [GE Healthcare, Waukesha, Wis] and Ingenia) on the same day to estimate hepatic PDFF...
February 17, 2017: Radiology
https://www.readbyqxmd.com/read/28196133/b1-insensitive-t2-mapping-of-healthy-thigh-muscles-using-a-t2-prepared-3d-tse-sequence
#18
Elisabeth Klupp, Dominik Weidlich, Sarah Schlaeger, Thomas Baum, Barbara Cervantes, Marcus Deschauer, Hendrik Kooijman, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos
PURPOSE: To propose a T2-prepared 3D turbo spin echo (T2prep 3D TSE) sequence for B1-insensitive skeletal muscle T2 mapping and compare its performance with 2D and 3D multi-echo spin echo (MESE) for T2 mapping in thigh muscles of healthy subjects. METHODS: The performance of 2D MESE, 3D MESE and the proposed T2prep 3D TSE in the presence of transmit B1 and B0 inhomogeneities was first simulated. The thigh muscles of ten young and healthy subjects were then scanned on a 3 T system and T2 mapping was performed using the three sequences...
2017: PloS One
https://www.readbyqxmd.com/read/28190853/high-snr-acquisitions-improve-the-repeatability-of-liver-fat-quantification-using-confounder-corrected-chemical-shift-encoded-mr-imaging
#19
Utaroh Motosugi, Diego Hernando, Curtis Wiens, Peter Bannas, Scott B Reeder
PURPOSE: To determine whether high signal-to-noise ratio (SNR) acquisitions improve the repeatability of liver proton density fat fraction (PDFF) measurements using confounder-corrected chemical shift-encoded magnetic resonance (MR) imaging (CSE-MRI). MATERIALS AND METHODS: Eleven fat-water phantoms were scanned with 8 different protocols with varying SNR. After repositioning the phantoms, the same scans were repeated to evaluate the test-retest repeatability. Next, an in vivo study was performed with 20 volunteers and 28 patients scheduled for liver magnetic resonance imaging (MRI)...
February 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28116801/assessment-of-treatment-response-in-non-alcoholic-steatohepatitis-using-advanced-magnetic-resonance-imaging
#20
S C Lin, E Heba, R Bettencourt, G Y Lin, M A Valasek, O Lunde, G Hamilton, C B Sirlin, R Loomba
BACKGROUND: Magnetic resonance imaging-derived measures of liver fat and volume are emerging as accurate, non-invasive imaging biomarkers in non-alcoholic steatohepatitis (NASH). Little is known about these measures in relation to histology longitudinally. AIM: To examine any relationship between MRI-derived proton-density fat-fraction (PDFF), total liver volume (TLV), total liver fat index (TLFI), vs. histology in a NASH trial. METHODS: This is a secondary analysis of a 24-week randomised, double-blind, placebo-controlled trial of 50 patients with biopsy-proven NASH randomised to oral ezetimibe 10 mg daily (n = 25) vs...
March 2017: Alimentary Pharmacology & Therapeutics
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