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Proton density fat fraction

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https://www.readbyqxmd.com/read/29325281/-value-of-hydrogen-proton-magnetic-resonance-spectroscopy-in-the-determination-of-liver-triglyceride-in-patients-with-fatty-liver-disease-and-its-influencing-factors
#1
H J Qu, L Wang, P H Jin, Q Gao, J X Zhou, Y Song, J Wang, Y M Jiang, L Gong, G Y Chen, J P Ding, J P Shi
Objective: To investigate the value of 1H-magnetic resonance spectroscopy ((1)H-MRS) in determining the content of liver triglyceride in patients with fatty liver disease (FLD), as well as its influencing factors. Methods: A total of 124 patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis B (CHB), or hepatitis B complicated by FLD who underwent liver biopsy in the Affiliated Hospital of Hangzhou Normal University were enrolled, and the clinical data, serological markers, FibroScan results, and (1)H-MRS results were collected...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29322549/noise-properties-of-proton-density-fat-fraction-estimated-using-chemical-shift-encoded-mri
#2
Nathan T Roberts, Diego Hernando, James H Holmes, Curtis N Wiens, Scott B Reeder
PURPOSE: The purpose of this work is to characterize the noise distribution of proton density fat fraction (PDFF) measured using chemical shift-encoded MRI, and to provide alternative strategies to reduce bias in PDFF estimation. THEORY: We derived the probability density function for PDFF estimated using chemical shift-encoded MRI, and found it to exhibit an asymmetric noise distribution that contributes to signal-to-noise-ratio dependent bias. METHODS: To study PDFF noise bias, we performed (at 1...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29313118/proton-density-fat-fraction-pdff-mri-for-differentiation-of-benign-and-malignant-vertebral-lesions
#3
Frederic Carsten Schmeel, Julian Alexander Luetkens, Peter Johannes Wagenhäuser, Michael Meier-Schroers, Daniel Lloyd Kuetting, Andreas Feißt, Jürgen Gieseke, Leonard Christopher Schmeel, Frank Träber, Hans Heinz Schild, Guido Matthias Kukuk
OBJECTIVES: To investigate whether proton density fat fraction (PDFF) measurements using a six-echo modified Dixon sequence can help to differentiate between benign and malignant vertebral bone marrow lesions. METHODS: Sixty-six patients were prospectively enrolled in our study. In addition to conventional MRI at 3.0-Tesla including at least sagittal T2-weighted/spectral attenuated inversion recovery and T1-weighted sequences, all patients underwent a sagittal six-echo modified Dixon sequence of the spine...
January 8, 2018: European Radiology
https://www.readbyqxmd.com/read/29249127/liver-transplantation-for-non-alcoholic-fatty-liver-disease
#4
Giacomo Germani, Chiara Becchetti
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MS) [1], and it is defined by the presence of steatosis in >5% of hepatocytes, according to histological analysis or detected by specific proton density fat fraction obtained MRI. The term NAFLD covers two pathologically distinct conditions: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), which can have similar clinical presentation, but with different prognosis. Both conditions can lastly lead to the development of cirrhosis...
December 15, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29238866/validation-of-goose-liver-fat-measurement-by-qct-and-cse-mri-with-biochemical-extraction-and-pathology-as-reference
#5
Li Xu, Yangyang Duanmu, Glen M Blake, Chenxin Zhang, Yong Zhang, Keenan Brown, Xiaoqi Wang, Peng Wang, Xingang Zhou, Manling Zhang, Chao Wang, Zhe Guo, Giuseppe Guglielmi, Xiaoguang Cheng
OBJECTIVES: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. METHODS: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical measurement and histology...
December 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29218660/how-bariatric-surgery-affects-liver-volume-and-fat-density-in-nafld-patients
#6
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29199057/epidemiology-of-hepatic-steatosis-at-a-tertiary-care-center-an-mri-based-analysis
#7
Tyler J Fraum, Daniel R Ludwig, Scott Kilian, William A Curtis, Thomas K Pilgram, Claude B Sirlin, Kathryn J Fowler
RATIONALE AND OBJECTIVES: Little is known about the frequency and risk factors of hepatic steatosis in the tertiary care setting. Such knowledge is essential to clinicians making decisions about testing for this condition. Thus, our aim was to describe the epidemiology of hepatic steatosis, as captured by magnetic resonance imaging (MRI), at a tertiary care center. MATERIALS AND METHODS: A near-consecutive cohort of 1006 adult patients underwent standard-of-care liver MRIs...
December 1, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29176468/fat-quantification-in-the-abdomen
#8
Cheng William Hong, Soudabeh Fazeli Dehkordy, Jonathan C Hooker, Gavin Hamilton, Claude B Sirlin
Fatty liver disease is characterized histologically by hepatic steatosis, the abnormal accumulation of lipid in hepatocytes. It is classified into alcoholic fatty liver disease and nonalcoholic fatty liver disease, and is an increasingly important cause of chronic liver disease and cirrhosis. Assessing the severity of hepatic steatosis in these conditions is important for diagnostic and prognostic purposes, as hepatic steatosis is potentially reversible if diagnosed early. The criterion standard for assessing hepatic steatosis is liver biopsy, which is limited by sampling error, its invasive nature, and associated morbidity...
December 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29130539/sources-of-systematic-error-in-proton-density-fat-fraction-pdff-quantification-in-the-liver-evaluated-from-magnitude-images-with-different-numbers-of-echoes
#9
Mark Bydder, Gavin Hamilton, Ludovic de Rochefort, Ajinkya Desai, Elhamy R Heba, Rohit Loomba, Jeffrey B Schwimmer, Nikolaus M Szeverenyi, Claude B Sirlin
The purpose of this work was to investigate sources of bias in magnetic resonance imaging (MRI) liver fat quantification that lead to a dependence of the proton density fat fraction (PDFF) on the number of echoes. This was a retrospective analysis of liver MRI data from 463 subjects. The magnitude signal variation with TE from spoiled gradient echo images was curve fitted to estimate the PDFF using a model that included monoexponential R2 * decay and a multi-peak fat spectrum. Additional corrections for non-exponential decay (Gaussian), bi-exponential decay, degree of fat saturation, water frequency shift and noise bias were introduced...
November 12, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29108123/optimal-threshold-of-controlled-attenuation-parameter-with-mri-pdff-as-the-gold-standard-for-the-detection-of-hepatic-steatosis
#10
Cyrielle Caussy, Mosab H Alquiraish, Phirum Nguyen, Carolyn Hernandez, Sandra Cepin, Lynda E Fortney, Veeral Ajmera, Ricki Bettencourt, Summer Collier, Jonathan Hooker, Ethan Sy, Emily Rizo, Lisa Richards, Claude B Sirlin, Rohit Loomba
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD). Magnetic resonance imaging proton-density-fat-fraction (MRI-PDFF) is an accurate and precise method to detect presence of hepatic steatosis and is better than CAP. Thus, the aim of this study was to evaluate the diagnostic accuracy and the optimal threshold of CAP for the detection of hepatic steatosis as defined by MRI-PDFF ≥ 5%...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29089822/impact-of-liver-fibrosis-and-fatty-liver-on-t1rho-measurements-a-prospective-study
#11
Shuangshuang Xie, Qing Li, Yue Cheng, Yu Zhang, Zhizheng Zhuo, Guiming Zhao, Wen Shen
OBJECTIVE: To investigate the liver T1rho values for detecting fibrosis, and the potential impact of fatty liver on T1rho measurements. MATERIALS AND METHODS: This study included 18 healthy subjects, 18 patients with fatty liver, and 18 patients with liver fibrosis, who underwent T1rho MRI and mDIXON collections. Liver T1rho, proton density fat fraction (PDFF) and T2* values were measured and compared among the three groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the T1rho values for detecting liver fibrosis...
November 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29080242/can-negligible-hepatic-steatosis-determined-by-mri-proton-density-fat-fraction-obviate-the-need-for-liver-biopsy-in-potential-liver-donors
#12
Janakan Satkunasingham, Hooman Hosseini Nik, Sandra Fischer, Ravi Menezes, Nazia Selzner, Mark Cattral, David Grant, Kartik Jhaveri
PURPOSE: To determine whether magnetic resonance proton density fat fraction (MR-PDFF) estimate of negligible hepatic fat percentage (<5%) can exclude significant hepatic steatosis (≥ 10%) in living liver donor candidates obviating the need for liver biopsy. To perform intra-individual comparisons between MR-PDFF techniques for hepatic steatosis quantification. MATERIALS AND METHODS: In an ethics approved retrospective study, 144 liver donor candidates with MR spectroscopy (MRS) and six-echo Dixon MRI between 2013 and 2015 were included...
October 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29063256/sciatic-neurosteatosis-relationship-with-age-gender-obesity-and-height
#13
Shayna Ratner, Raamis Khwaja, Lihua Zhang, Yin Xi, Riham Dessouky, Craig Rubin, Avneesh Chhabra
AIM: To evaluate inter-reader performance for cross-sectional area and fat quantification of bilateral sciatic nerves on MRI and assess correlations with anthropometrics. METHODS: In this IRB-approved, HIPPA-compliant study, three readers performed a cross-sectional analysis of 3T lumbosacral plexus MRIs over an 18-month period. Image slices were evaluated at two levels (A and B). The sciatic nerve was outlined using a free hand region of interest tool on PACS. Proton-density fat fraction (FF) and cross-sectional areas were recorded...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29058029/increased-severity-of-liver-fat-content-and-liver-fibrosis-in-non-alcoholic-fatty-liver-disease-correlate-with-epicardial-fat-volume-in-type-2-diabetes-a-prospective-study
#14
Sharon S Brouha, Phirum Nguyen, Ricki Bettencourt, Claude B Sirlin, Rohit Loomba
OBJECTIVES: To determine whether severity of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis quantitatively assessed in individuals with diabetes mellitus (DM)-2 correlate with increased coronary heart disease (CHD) risk using non-invasive markers. METHODS: We conducted a single-centre, prospective, cross-sectional study in 100 consecutive diabetic individuals without known CHD recruited between March 2013 and September 2014. History, physical examination, serum markers, cardiac computed tomography (CT), magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) and MR elastography (MRE) were obtained for 95 participants...
October 20, 2017: European Radiology
https://www.readbyqxmd.com/read/29028128/diagnostic-accuracy-of-magnetic-resonance-imaging-hepatic-proton-density-fat-fraction-in-pediatric-nonalcoholic-fatty-liver-disease
#15
Michael S Middleton, Mark L Van Natta, Elhamy R Heba, Adina Alazraki, Andrew T Trout, Prakash Masand, Elizabeth M Brunt, David E Kleiner, Edward Doo, James Tonascia, Joel E Lavine, Wei Shen, Gavin Hamilton, Jeffrey B Schwimmer, Claude B Sirlin
We assessed the performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in children to stratify hepatic steatosis grade before and after treatment in the Cysteamine Bitartrate Delayed-Release for the Treatment of Nonalcoholic Fatty Liver Disease in Children (CyNCh) trial, using centrally-scored histology as reference. Participants had multi-echo 1.5T or 3T MRI on scanners from three manufacturers. Of 169 enrolled children, 110 (65%) and 83 (49%) had MRI and liver biopsy at baseline and at end-of-treatment (EOT; 52-weeks), respectively...
October 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29022777/feasibility-of-modified-dixon-mri-techniques-for-hepatic-fat-quantification-in-hepatic-disorders-validation-with-mrs-and-histology
#16
Bo-Kyeong Kang, Mimi Kim, Soon-Young Song, Dae Won Jun, Kiseok Jang
OBJECTIVE: To assess the feasibility of proton density fat fraction (PDFF) MRI for estimating hepatic fat fraction with magnetic resonance spectroscopy (MRS) and histology as references and to investigate intrahepatic fat distribution and variability. METHODS: Between November 2014 and September 2015, 85 adults (48 males, 47 females) who underwent MRI-PDFF (n = 139), MRS-PDFF (n = 49) and liver biopsy (n = 29) were enrolled in this study. Data were compared using linear regression...
November 8, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28931343/impact-of-bowel-gas-and-body-outline-variations-on-total-accumulated-dose-with-intensity-modulated-proton-therapy-in-locally-advanced-cervical-cancer-patients
#17
Thomas Berger, Jørgen Breede Baltzer Petersen, Jacob Christian Lindegaard, Lars Ulrik Fokdal, Kari Tanderup
INTRODUCTION: Density changes occurring during fractionated radiotherapy in the pelvic region may degrade proton dose distributions. The aim of the study was to quantify the dosimetric impact of gas cavities and body outline variations. MATERIAL AND METHODS: Seven patients with locally advanced cervical cancer (LACC) were analyzed through a total of 175 daily cone beam computed tomography (CBCT) scans. Four-beams intensity-modulated proton therapy (IMPT) dose plans were generated targeting the internal target volume (ITV) composed of: primary tumor, elective and pathological nodes...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28915103/mr-spectroscopy-derived-proton-density-fat-fraction-is-superior-to-controlled-attenuation-parameter-for-detecting-and-grading-hepatic-steatosis
#18
Jurgen Henk Runge, Loek Pieter Smits, Joanne Verheij, Annekatrien Depla, Sjoerd Douwe Kuiken, Bert Cornelis Baak, Aart Johannes Nederveen, Ulrich Beuers, Jaap Stoker
Purpose To prospectively compare the diagnostic accuracy of controlled attenuation parameter (CAP) obtained with transient elastography and proton density fat fraction (PDFF) obtained with proton magnetic resonance (MR) spectroscopy with results of liver biopsy in a cohort of adult patients suspected of having nonalcoholic fatty liver disease (NAFLD). Materials and Methods The institutional review board approved this study. Informed consent was obtained from all patients. The authors evaluated 55 patients suspected of having NAFLD (40 men, 15 women)...
September 15, 2017: Radiology
https://www.readbyqxmd.com/read/28895045/influence-of-gd-eob-dtpa-on-proton-density-fat-fraction-using-the-six-echo-dixon-method-in-3-tesla-magnetic-resonance-imaging
#19
Tatsuya Hayashi, Kei Fukuzawa, Hiroshi Kondo, Hiroshi Onodera, Shuji Toyotaka, Rie Tojo, Shimpei Yano, Masakatsu Tano, Tosiaki Miyati, Jun'ichi Kotoku, Takahide Okamoto, Keiko Toyoda, Hiroshi Oba
The purpose of this study was to evaluate whether disodium gadoxetate (Gd-EOB-DTPA) affects proton density fat fractions (PDFFs) during use of the multiecho Dixon (meDixon) method in phantom and simulation magnetic resonance imaging (MRI) studies at 3 T. Fat-water phantoms comprising vegetable fat-water emulsions with varying fat volume percentages (0, 5, 10, 15, 20, 30, 40, and 50) and Gd-EOB-DTPA concentrations (0 and 0.4 mM) were prepared. Phantoms without Gd-EOB-DTPA were defined as precontrast, and those with Gd-EOB-DTPA were defined as postcontrast...
September 11, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28894290/association-of-proton-density-fat-fraction-in-adipose-tissue-with-imaging-based-and-anthropometric-obesity-markers-in-adults
#20
D Franz, D Weidlich, F Freitag, C Holzapfel, T Drabsch, T Baum, H Eggers, A Witte, E J Rummeny, H Hauner, D C Karampinos
BACKGROUND/OBJECTIVES: The purpose of this study was to examine the relationship of the proton density fat fraction (PDFF), measured by magnetic resonance imaging (MRI), of supraclavicular and gluteal adipose tissue with subcutaneous and visceral adipose tissue (SAT and VAT) volumes, liver fat fraction and anthropometric obesity markers. The supraclavicular fossa was selected as a typical location where brown adipocytes may be present in humans and the gluteal region was selected as a typical location enclosing primarily white adipocytes...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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