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https://www.readbyqxmd.com/read/27435415/health-economic-analyses-of-psoriasis-management-a-systematic-literature-search
#1
Mandy Gutknecht, Magdalene Krensel, Matthias Augustin
In the course of the chronic skin disease psoriasis, where a variety of treatment interventions is available, a strong growth of health economic studies comparing treatment costs and benefits can be noticed. The objective was to identify health economic evaluations of psoriasis treatments that have been published to date. Of particular interest were the mostly used analysis and outcome parameters, the compared treatments, and the question, if available health economic studies may be used to perform a meta-analysis of qualitative findings...
November 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27307041/monooxygenase-substrates-mimic-flavin-to-catalyze-cofactorless-oxygenations
#2
Melodie M Machovina, Robert J Usselman, Jennifer L DuBois
Members of the antibiotic biosynthesis monooxygenase family catalyze O2-dependent oxidations and oxygenations in the absence of any metallo- or organic cofactor. How these enzymes surmount the kinetic barrier to reactions between singlet substrates and triplet O2 is unclear, but the reactions have been proposed to occur via a flavin-like mechanism, where the substrate acts in lieu of a flavin cofactor. To test this model, we monitored the uncatalyzed and enzymatic reactions of dithranol, a substrate for the nogalamycin monooxygenase (NMO) from Streptomyces nogalater As with flavin, dithranol oxidation was faster at a higher pH, although the reaction did not appear to be base-catalyzed...
August 19, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27215754/-psoriasis-in-special-localizations
#3
A Schmieder, W K Peitsch
A large proportion of patients with plaque psoriasis suffer from psoriatic lesions of the scalp, nails, and intertrigines. These locations can also be soley or predominantly affected. Scalp psoriasis, nail psoriasis, and inverse psoriasis are often perceived as particularly stigmatizing. Involvement of these parts of the body is associated with an increased risk of psoriatic arthritis. Location-specific features must be considered when choosing treatment. Evidence for topical therapy of scalp psoriasis with steroids and combinations of steroids and vitamin D analogues is high...
June 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/26915340/topical-treatments-for-scalp-psoriasis
#4
REVIEW
Justin Gabriel Schlager, Stefanie Rosumeck, Ricardo Niklas Werner, Anja Jacobs, Jochen Schmitt, Christoph Schlager, Alexander Nast
BACKGROUND: People with chronic plaque psoriasis often have lesions on the scalp. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments. OBJECTIVES: To assess the efficacy and safety of topical treatments for scalp psoriasis. SEARCH METHODS: We searched the following databases up to August 2015: the Cochrane Skin Group Specialised Register, CENTRAL (2015, Issue 7), MEDLINE (from 1946), EMBASE (from 1974) and LILACS (from 1982)...
February 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26895458/dithranol-treatment-of-plaque-type-psoriasis-increases-serum-tnf-like-weak-inducer-of-apoptosis-tweak
#5
Hanna Myśliwiec, Piotr Myśliwiec, Anna Baran, Iwona Flisiak
PURPOSE: TNF-like weak inducer of apoptosis (TWEAK) mediates not only apoptosis, but also inflammation, cell growth and angiogenesis. The role of TWEAK in psoriasis remains unknown. The aim of the study was to assess serum levels of TWEAK in psoriatic patients before and after topical treatment with dithranol in relation to the clinical activity of the disease. MATERIAL AND METHODS: Serum samples were collected from 40 patients with plaque type psoriasis before and after topical treatment with dithranol...
January 21, 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/26522310/use-of-advantageous-volatile-matrices-enabled-by-next-generation-high-speed-matrix-assisted-laser-desorption-ionization-time-of-flight-imaging-employing-a-scanning-laser-beam
#6
Nina Ogrinc Potočnik, Tiffany Porta, Michael Becker, Ron M A Heeren, Shane R Ellis
RATIONALE: In mass spectrometry imaging (MSI) it is often desirable to analyse the same sample in both polarities to extract the most information. However, many matrices that produce high-quality spectra in matrix-assisted laser desorption/ionization (MALDI) are volatile, greatly limiting their use in long imaging experiments. We demonstrate that using a new high speed MALDI-MSI instrument, volatile matrices, including those that produce intense lipid signals in both positive and negative ion mode, can now be effectively used in MSI...
December 15, 2015: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/26513077/die-behandlung-der-psoriasis-mit-klassischer-station%C3%A3-rer-dithranol-therapie-eine-retrospektive-patientenbefragung
#7
Clemens Painsi, Michael Patscheider, Martin Inzinger, Bernhard Lange-Asschenfeldt, Franz Quehenberger, Peter Wolf
BACKGROUND: Evidence of the efficacy of dithranol and patient perspectives on the treatment is scant. PATIENTS AND METHODS: Using a telephone interview survey, we collected retrospective data from 63 patients (41 men [65.1 %] and 22 women [34.9 %]) who had been treated with classic inpatient dithranol (CID). PsoRA (www.psoriasisregistry.at) was used to obtain clinical data and treatment responses, which were then correlated with the interview responses. RESULTS: Fifty-two (82...
November 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/26513076/patient-perspectives-on-treating-psoriasis-with-classic-inpatient-dithranol-therapy-a-retrospective-patient-survey
#8
Clemens Painsi, Michael Patscheider, Martin Inzinger, Bernhard Lange-Asschenfeldt, Franz Quehenberger, Peter Wolf
BACKGROUND: Evidence of the efficacy of dithranol and patient perspectives on the treatment is scant. PATIENTS AND METHODS: Using a telephone interview survey, we collected retrospective data from 63 patients (41 men [65.1 %] and 22 women [34.9 %]) who had been treated with classic inpatient dithranol (CID). PsoRA (www.psoriasisregistry.at) was used to obtain clinical data and treatment responses, which were then correlated with the interview responses. RESULTS: Fifty-two (82...
November 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/26295850/tobacco-associated-yellow-discoloration-of-upper-lip-hair-smoker-s-mustache
#9
Bryce D Beutler, Philip R Cohen
BACKGROUND: Hair is susceptible to exogenous sources of discoloration. There are several exogenous etiologies for yellow hair discoloration, including tobacco. PURPOSE: We describe the clinical features of five men with tobacco-associated yellow discoloration of their mustache, a condition known as "smoker's mustache." We also review the characteristics of men with tobacco-associated yellow discoloration of their scalp or mustache hair. MATERIALS AND METHODS: The features of five men with smoker's mustache are presented...
May 2015: Dermatology Online Journal
https://www.readbyqxmd.com/read/26278099/dissociative-electron-attachment-to-anthralin-to-model-its-biochemical-reactions
#10
Stanislav A Pshenichnyuk, Alexei S Komolov
The antipsoriatic drug anthralin (dithranol) is known to be extensively accumulated inside mitochondria of keratinocytes and to interact with the electron flow of the respiratory chain. Primary products of the one-electron reduction of polyphenolic anthralin observed in vivo are its dehydrogenated anions, which are formed by H-atom abstraction. The same species are mainly generated at low electron energies by dissociative electron attachment (DEA) to anthralin molecules in vacuo. A likely mechanism for the biochemical transformations of anthralin under reductive conditions in vivo is hypothesized on the basis of its DEA properties...
August 21, 2014: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/26018604/exploring-the-mode-of-action-of-dithranol-therapy-for-psoriasis-a-metabolomic-analysis-using-hacat-cells
#11
Katherine A Hollywood, Catherine L Winder, Warwick B Dunn, Yun Xu, David Broadhurst, Christopher E M Griffiths, Royston Goodacre
Psoriasis is a common, immune-mediated inflammatory skin disease characterized by red, heavily scaled plaques. The disease affects over one million people in the UK and causes significant physical, psychological and societal impact. There is limited understanding regarding the exact pathogenesis of the disease although it is believed to be a consequence of genetic predisposition and environmental triggers. Treatments vary from topical therapies, such as dithranol, for disease of limited extent (<5% body surface area) to the new immune-targeted biologic therapies for severe psoriasis...
August 2015: Molecular BioSystems
https://www.readbyqxmd.com/read/25976392/improvement-of-chlorophyll-identification-in-foodstuffs-by-maldi-tof-tof-mass-spectrometry-using-1-5-diaminonaphthalene-electron-transfer-secondary-reaction-matrix
#12
Cosima Damiana Calvano, Giovanni Ventura, Tommaso R I Cataldi, Francesco Palmisano
Chlorophylls (Chls) are important pigments responsible for the characteristic green color of chloroplasts in algae and plants. In this study, 1,5-diaminonaphthalene (DAN) was introduced as an electron transfer secondary reaction matrix for the identification of intact chlorophylls and their derivatives, by matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS). DAN was proved to drastically outperform conventional matrices such as α-cyano-4-hydroxycinnnamic acid, dithranol, antracene, and even terthiophene, since loss of the metal ion and fragmentation of the phytol-ester linkage are negligible...
August 2015: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/25866313/matrix-normalized-maldi-tof-quantification-of-a-fluorotelomer-based-acrylate-polymer
#13
Keegan Rankin, Scott A Mabury
The degradation of fluorotelomer-based acrylate polymers (FTACPs) has been hypothesized to serve as a source of the environmental contaminants, perfluoroalkyl carboxylates (PFCAs). Studies have relied on indirect measurement of presumed degradation products to evaluate the environmental fate of FTACPs; however, this approach leaves a degree of uncertainty. The present study describes the development of a quantitative matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry method as the first direct analysis method for FTACPs...
May 19, 2015: Environmental Science & Technology
https://www.readbyqxmd.com/read/25491961/dithranol-loaded-lipid-core-nanocapsules-improve-the-photostability-and-reduce-the-in-vitro-irritation-potential-of-this-drug
#14
Ana L Savian, Daiane Rodrigues, Julia Weber, Roseane F Ribeiro, Mariana H Motta, Scheila R Schaffazick, Andréa I H Adams, Diego F de Andrade, Ruy C R Beck, Cristiane B da Silva
Dithranol is a very effective drug for the topical treatment of psoriasis. However, it has some adverse effects such as irritation and stain in the skin that make its application and patient adherence to treatment difficult. The aims of this work were to prepare and characterize dithranol-loaded nanocapsules as well as to evaluate the photostability and the irritation potential of these nanocarriers. Lipid-core nanocapsules containing dithranol (0.5 mg/mL) were prepared by interfacial deposition of preformed polymer...
January 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/25437350/upregulation-of-the-sfas-sfasl-system-in-psoriatic-patients
#15
Hanna Myśliwiec, Anna Baran, Piotr Myśliwiec, Maria Górska, Iwona Flisiak
PURPOSE: Psoriasis is a chronic, recurrent, inflammatory disease. Recent investigations indicate its autoimmune pathogenesis. Apoptosis plays an important role in the development of many autoimmune diseases. The aim of this study was to evaluate the influence of topical treatment of psoriasis on soluble Fas (sFas) and soluble Fas-ligand (sFasL). MATERIAL/METHODS: Serum concentrations of sFas and sFasL were measured using ELISA in 40 psoriatic patients before and after topical treatment with dithranol and compared to the values obtained from 16 healthy subjects...
March 2015: Advances in Medical Sciences
https://www.readbyqxmd.com/read/25255914/porokeratotic-adnexal-ostial-naevus-review-on-the-entity-and-therapeutic-approach
#16
REVIEW
M Llamas-Velasco, N Hilty, W Kempf
BACKGROUND: Porokeratotic adnexal ostial nevus (PAON) is a term that encompass porokeratotic eccrine ostial and dermal duct naevus and porokeratotic eccrine and hair follicle naevus. PAON is a rare adnexal hamartoma characterized by the presence of a cornoid lamella exclusively overlying eccrine acrosyringia or over both, eccrine acrosyringia and hair follicles. OBJECTIVES: Most of the articles on PAON report its clinical or histopathological characteristics but literature review offer scarce data on the evolution or treatment...
October 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/25208745/anthralin-dithranol-in-dermatology
#17
REVIEW
Virendra N Sehgal, Prashant Verma, Ananta Khurana
Anthralin (1,8-dihydroxy-9anthrone, dithranol) was first synthesized as a derivative of chrysarobin, prepared from the araroba tree in Brazil over a century ago. Drawbacks to the use of anthralin include irritation and discoloration of the skin. This property of the molecule prompted workers to investigate details of its pharmacology, mode of action, and indications. The major point of this article is to highlight and revisit these aspects for pertinent future use. Therefore, it is worthwhile to consider that the drug is relatively innocuous, yet effective, and is devoid of any systemic side effects in contrast to a wide variety of systemic and topical therapies available for psoriasis and other dermatoses...
October 2014: International Journal of Dermatology
https://www.readbyqxmd.com/read/25007005/maldi-mass-spectrometry-imaging-of-bioactive-lipids-in-mouse-brain-with-a-synapt-g2-s-mass-spectrometer-operated-at-elevated-pressure-improving-the-analytical-sensitivity-and-the-lateral-resolution-to-ten-micrometers
#18
Hans Kettling, Simeon Vens-Cappell, Jens Soltwisch, Alexander Pirkl, Jörg Haier, Johannes Müthing, Klaus Dreisewerd
Mass spectrometers from the Synapt-G1/G2 family (Waters) are widely employed for matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). A lateral resolution of about 50 μm is typically achieved with these instruments, that is, however, below the often desired cellular resolution. Here, we show the first MALDI-MSI examples demonstrating a lateral resolution of about ten micrometers obtained with a Synapt G2-S HDMS mass spectrometer without oversampling. This improvement became possible by laser beam shaping using a 4:1 beam expander and a circular aperture for spatial mode filtering and by replacement of the default focusing lens...
August 5, 2014: Analytical Chemistry
https://www.readbyqxmd.com/read/24704633/physical-signatures-of-drug-transport-through-an-artificial-skin-barrier-a-proposed-model-and-its-validation
#19
Pawel Rochowski, Janusz Szurkowski
The objective of the present study is to better characterize the system acting as a model for the penetration of a pharmaceutical drug into the skin. With a new mathematical formalism, the transport of the drug (dithranol) from a semisolid vaseline suspension into an artificial membrane was described. In our novel approach, we have taken into account not only diffusion but also other effects dependent on chemical reactivity of drug, medium structure, and drug-matrix interactions. The transport equation was solved with two methods: the Laplace transform and the reflection-and-superposition...
May 1, 2014: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/24500042/-topical-therapy-of-inflammatory-dermatoses-pruritus-and-pain-as-well-as-hyperhidrosis
#20
REVIEW
K Schultheis, A Messerschmidt, F Ochsendorf
In this review, substances suitable for the topical treatment of inflammatory dermatoses, pruritus, pain and hyperhidrosis are presented. Both non-specific and specific topical treatments are discussed with respect to their mode of action, indications and side effects; included are corticosteroids, calcineurin inhibitors, dithranol, coal tar, liquor carbonis detergens, vitamin D analogues, metronidazole, azelaic acid, retinoids, and benzoyl peroxide. Additionally, practical directions for the treatment of these common skin diseases are provided...
March 2014: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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