keyword
https://read.qxmd.com/read/38434138/identification-of-a-shared-gene-signature-and-biological-mechanism-between-diabetic-foot-ulcers-and-cutaneous-lupus-erythemnatosus-by-transcriptomic-analysis
#21
JOURNAL ARTICLE
Siqi Wu, Yuetong Wang, Jingyi Duan, Ying Teng, Dali Wang, Fang Qi
Diabetic foot ulcers (DFU) and cutaneous lupus erythematosus (CLE) are both diseases that can seriously affect a patient's quality of life and generate economic pressure in society. Symptomatically, both DLU and CLE exhibit delayed healing and excessive inflammation; however, there is little evidence to support a molecular and cellular connection between these two diseases. In this study, we investigated potential common characteristics between DFU and CLE at the molecular level to provide new insights into skin diseases and regeneration, and identify potential targets for the development of new therapies...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38431537/computational-deciphering-of-the-role-of-s100a8-and-s100a9-proteins-and-their-changes-in-the-structure-assembly-influences-their-interaction-with-tlr4-rage-and-cd36
#22
JOURNAL ARTICLE
Sivasakthi Paramasivam, Senthamil Selvan Perumal, Sanmuga Priya Ekambaram
S100A8 and S100A9 belong to the calcium-binding, damage associated molecular pattern (DAMP) proteins shown to aggravate the pathogenesis of rheumatoid arthritis (RA) through their interaction with the TLR4, RAGE and CD36 receptors. S100A8 and S100A9 proteins tend to exist in monomeric, homo and heterodimeric forms, which have been implicated in the pathogenesis of RA, via interacting with Pattern Recognition receptors (PRRs). The study aims to assess the influence of changes in the structure and biological assembly of S100A8 and S100A9 proteins as well as their interaction with significant receptors in RA through computational methods and surface plasmon resonance (SPR) analysis...
March 2, 2024: Protein Journal
https://read.qxmd.com/read/38429401/mdsc-derived-s100a8-9-contributes-to-lupus-pathogenesis-by-promoting-tlr7-mediated-activation-of-macrophages-and-dendritic-cells
#23
JOURNAL ARTICLE
Yonghong Yang, Xin Zhang, Lina Jing, Yucai Xiao, Yangzhe Gao, Yuxin Hu, Shujiao Jia, Guangxi Zhou, Huabao Xiong, Guanjun Dong
Toll-like receptors (TLRs), especially TLR7, play an important role in systemic lupus erythematosus (SLE) pathogenesis. However, the regulatory mechanism underlying the abnormal activation of TLR pathways in patients with SLE has not been elucidated. Notably, accumulating evidence indicates that myeloid-derived suppressor cells (MDSCs) are important regulators of inflammation and autoimmune diseases. Compared with healthy control subjects, patients with SLE have a greater proportion of MDSCs among peripheral blood mononuclear cells (PBMCs); however, the effect of MDSCs on TLR7 pathway activation has not been determined...
March 1, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38429367/single-cell-atlas-reveals-the-immunosuppressive-microenvironment-and-treg-cells-landscapes-in-recurrent-glioblastoma
#24
JOURNAL ARTICLE
Xingdong Wang, Yizhi Ge, Yuting Hou, Xiaodong Wang, Zhengcun Yan, Yuping Li, Lun Dong, Lei She, Can Tang, Min Wei, Hengzhu Zhang
Patients diagnosed with glioblastoma (GBM) have the most aggressive tumor progression and lethal recurrence. Research on the immune microenvironment landscape of tumor and cerebrospinal fluid (CSF) is limited. At the single-cell level, we aim to reveal the recurrent immune microenvironment of GBM and the potential CSF biomarkers and compare tumor locations. We collected four clinical samples from two patients: malignant samples from one recurrent GBM patient and non-malignant samples from a patient with brain tumor...
March 1, 2024: Cancer Gene Therapy
https://read.qxmd.com/read/38429278/gasdermin-e-promotes-translocation-of-p65-and-c-jun-into-nucleus-in-keratinocytes-for-progression-of-psoriatic-skin-inflammation
#25
JOURNAL ARTICLE
Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen
Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized. Through analysis of GEO datasets, we found elevated GSDME levels in psoriatic lesional skin. Additionally, GSDME levels correlated with both psoriasis severity and response to biologics treatments. Single-cell RNA sequencing (scRNA-seq) from a GEO dataset revealed GSDME upregulation in keratinocytes of psoriasis patients...
March 1, 2024: Cell Death & Disease
https://read.qxmd.com/read/38420589/s100a9-aggravates-early-brain-injury-after-subarachnoid-hemorrhage-via-inducing-neuroinflammation-and-inflammasome-activation
#26
JOURNAL ARTICLE
Guijun Wang, Kesheng Huang, Qi Tian, Yujia Guo, Chengli Liu, Zhijie Li, Zhui Yu, Zhan Zhang, Mingchang Li
Subarachnoid hemorrhage (SAH) is a stroke subtype with high mortality, and its severity is closely related to the short-term prognosis of SAH patients. S100 calcium-binding protein A9 (S100A9) has been shown to be associated with some neurological diseases. In this study, the concentration of S100A9 in clinical cerebrospinal fluid samples was detected by enzyme-linked immunosorbent assay (ELISA), and the relationship between S100A9 and the prognosis of patients was explored. In addition, WT mice and S100A9 knockout mice were used to establish an in vivo SAH model...
March 15, 2024: IScience
https://read.qxmd.com/read/38419842/g-csf-increases-calprotectin-expression-liver-damage-and-neuroinflammation-in-a-murine-model-of-alcohol-induced-aclf
#27
JOURNAL ARTICLE
Martí Ortega-Ribera, Yuan Zhuang, Veronika Brezani, Prashanth Thevkar Nagesh, Radhika S Joshi, Mrigya Babuta, Yanbo Wang, Gyongyi Szabo
Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We aimed at dissecting the role of G-CSF in an alcohol-induced murine model of ACLF. Methods : ACLF was triggered by a single alcohol binge (5 g/kg) in a bile duct ligation (BDL) liver fibrosis model. A subgroup of mice received two G-CSF (200 μg/kg) or vehicle injections prior to acute decompensation with alcohol. Liver, blood and brain tissues were assessed...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38413479/association-study-of-s100a9-gene-polymorphisms-with-parkinson-s-disease-risk-and-age-of-disease-onset
#28
JOURNAL ARTICLE
Xingqiong Wang, Hanxuan Liu, Jian Li, Jingjing Jiang, Teng Li
PURPOSE: Intestinal inflammation is associated with several neurodegenerative diseases, including Parkinson's disease (PD). Intestinal inflammation is also closely related to genetic and environmental factors. S100 calcium-binding protein A9 (S100A9) is also thought to be genetically associated with intestinal inflammation and PD risk. This study investigated the association between S100A9 gene polymorphisms and PD risk and age of disease onset. METHODS: This study used a case-control method and included 242 PD patients and 242 healthy participants...
February 28, 2024: Acta Neurologica Belgica
https://read.qxmd.com/read/38403918/s100a8-enriched-microglia-populate-the-brain-of-tau-seeded-and-accelerated-aging-mice
#29
JOURNAL ARTICLE
Roxane Gruel, Baukje Bijnens, Johanna Van Den Daele, Sofie Thys, Roland Willems, Dirk Wuyts, Debby Van Dam, Peter Verstraelen, Rosanne Verboven, Jana Roels, Niels Vandamme, Renzo Mancuso, Juan Diego Pita-Almenar, Winnok H De Vos
Long considered to fluctuate between pro- and anti-inflammatory states, it has now become evident that microglia occupy a variegated phenotypic landscape with relevance to aging and neurodegeneration. However, whether specific microglial subsets converge in or contribute to both processes that eventually affect brain function is less clear. To investigate this, we analyzed microglial heterogeneity in a tauopathy mouse model (K18-seeded P301L) and an accelerated aging model (Senescence-Accelerated Mouse-Prone 8, SAMP8) using cellular indexing of transcriptomes and epitopes by sequencing...
February 25, 2024: Aging Cell
https://read.qxmd.com/read/38396791/apoe-isoforms-inhibit-amyloid-aggregation-of-proinflammatory-protein-s100a9
#30
JOURNAL ARTICLE
Shamasree Ghosh, Shanmugam Tamilselvi, Chloe Williams, Sanduni W Jayaweera, Igor A Iashchishyn, Darius Šulskis, Jonathan D Gilthorpe, Anders Olofsson, Vytautas Smirnovas, Željko M Svedružić, Ludmilla A Morozova-Roche
Increasing evidence suggests that the calcium-binding and proinflammatory protein S100A9 is an important player in neuroinflammation-mediated Alzheimer's disease (AD). The amyloid co-aggregation of S100A9 with amyloid-β (Aβ) is an important hallmark of this pathology. Apolipoprotein E (ApoE) is also known to be one of the important genetic risk factors of AD. ApoE primarily exists in three isoforms, ApoE2 (Cys112/Cys158), ApoE3 (Cys112/Arg158), and ApoE4 (Arg112/Arg158). Even though the difference lies in just two amino acid residues, ApoE isoforms produce differential effects on the neuroinflammation and activation of the microglial state in AD...
February 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38395520/protective-effect-and-regulatory-mechanism-of-salidroside-on-skin-inflammation-induced-by-imiquimod-in-psoriasis-mice
#31
JOURNAL ARTICLE
Zhenxing Su, Yunqin Kang
Salidroside (SAL) is a glucoside of tyrosol commonly existing in the roots of Rhodiola rosea. This study unveils the protective effect of SAL on skin inflammation in imiquimod (IMQ)-induced psoriasis. The mouse model of psoriasis was established by local application of IMQ, and SAL efficacy was evaluated through PASI scoring, H&E staining, and skin tissue pathology observation. The HaCaT cell model was established by interferon (IFN)-γ induction, followed by MTT assay detection of cell viability, detection of ROS, SOD, MDA, and CAT levels in skin tissues and cells using reagent kits, ELISA detection of inflammatory factors (TNF-α, IL-6, IL-1β), and qRT-PCR detection of psoriasis-related genes (S100a9, Cxcl1, Cxcl2) as well as miR-369-3p and SMAD2 expressions...
March 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38385005/identification-and-verification-of-novel-biomarkers-involving-rheumatoid-arthritis-with-multimachine-learning-algorithms-an-in-silicon-and-in-vivo-study
#32
JOURNAL ARTICLE
Fucun Liu, Juelan Ye, Shouli Wang, Yang Li, Yuhang Yang, Jianru Xiao, Aimin Jiang, Xuhua Lu, Yunli Zhu
BACKGROUND: Rheumatoid arthritis (RA) remains one of the most prevalent chronic joint diseases. However, due to the heterogeneity among RA patients, there are still no robust diagnostic and therapeutic biomarkers for the diagnosis and treatment of RA. METHODS: We retrieved RA-related and pan-cancer information datasets from the Gene Expression Omnibus and The Cancer Genome Atlas databases, respectively. Six gene expression profiles and corresponding clinical information of GSE12021, GSE29746, GSE55235, GSE55457, GSE77298, and GSE89408 were adopted to perform differential expression gene analysis, enrichment, and immune component difference analyses of RA...
2024: Mediators of Inflammation
https://read.qxmd.com/read/38378778/high-s100a9-level-predicts-poor-survival-and-the-s100a9-inhibitor-paquinimod-is-a-candidate-for-treating-idiopathic-pulmonary-fibrosis
#33
JOURNAL ARTICLE
Shinichiro Miura, Hiroshi Iwamoto, Masashi Namba, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
BACKGROUND: S100A9 is a damage-associated molecular pattern protein that may play an important role in the inflammatory response and fibrotic processes. Paquinimod is an immunomodulatory compound that prevents S100A9 activity. Its safety and pharmacokinetics have been confirmed in human clinical trials. In this study, we investigated the effects of paquinimod in preventing the development of lung fibrosis in vivo and examined the prognostic values of circulatory and lung S100A9 levels in patients with idiopathic pulmonary fibrosis (IPF)...
February 20, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38368714/hnrnpl-facilitates-ferroptosis-in-hepatocellular-carcinoma-cells-by-promoting-s100a9-expression
#34
JOURNAL ARTICLE
Lanfang Yang, Zhibo Zhang, Xiangqing Yao, Xukun Wu, Zhao Zhang
OBJECTIVE: This study probed into the effect of HNRNPL on ferroptosis in hepatocellular carcinoma (HCC) cells and related molecular mechanisms. METHODS: Expression patterns of HNRNPL, Recombinant S100 Calcium Binding Protein A9 (S100A9) were analyzed in HCC tissues or cells. Following transfection, HCC cell activity was analyzed, followed by detection of levels of ROS, iron content, LPO, MDA, and GSH as well as the expression of ferroptosis-related proteins. For molecular mechanism, RIP, RNA pull-down assay and actinomycin D assay were implemented to verify the binding relationship between HNRNPL and S100A9...
February 17, 2024: Translational Oncology
https://read.qxmd.com/read/38364346/diesel-exhaust-particle-exposure-exacerbates-ciliary-and-epithelial-barrier-dysfunction-in-the-multiciliated-bronchial-epithelium-models
#35
JOURNAL ARTICLE
Eunsook Park, Bu-Yeo Kim, Seahyoung Lee, Kuk Hui Son, Jihye Bang, Se Hyang Hong, Joong Won Lee, Kyung-Ok Uhm, Hyun-Jeong Kwak, Hyun Joung Lim
Airway epithelium, the first defense barrier of the respiratory system, facilitates mucociliary clearance against inflammatory stimuli, such as pathogens and particulates inhaled into the airway and lung. Inhaled particulate matter 2.5 (PM2.5 ) can penetrate the alveolar region of the lung, and it can develop and exacerbate respiratory diseases. Although the pathophysiological effects of PM2.5 in the respiratory system are well known, its impact on mucociliary clearance of airway epithelium has yet to be clearly defined...
February 15, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38356516/systematic-review-and-bioinformatics-analysis-of-plasma-and-serum-extracellular-vesicles-proteome-in-type-2-diabetes
#36
JOURNAL ARTICLE
Jeanette Guadalupe Arredondo-Damián, Juan Manuel Martínez-Soto, Francisco A Molina-Pelayo, Jesús Adriana Soto-Guzmán, Luis Castro-Sánchez, Luis Fernando López-Soto, Maria Del Carmen Candia-Plata
BACKGROUND: Type 2 diabetes (T2D) is a complex metabolic ailment marked by a global high prevalence and significant attention in primary healthcare settings due to its elevated morbidity and mortality rates. The pathophysiological mechanisms underlying the onset and progression of this disease remain subjects of ongoing investigation. Recent evidence underscores the pivotal role of the intricate intercellular communication network, wherein cell-derived vesicles, commonly referred to as extracellular vesicles (EVs), emerge as dynamic regulators of diabetes-related complications...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38356443/mesothelin-secretion-by-pancreatic-cancer-cells-co-opts-macrophages-and-promotes-metastasis
#37
JOURNAL ARTICLE
Teifion Luckett, Maidinaimu Abudula, Lucy Ireland, Mark Glenn, Gaia Bellomo, Ruth Stafferton, Chris Halloran, Paula Ghaneh, Rob Jones, Michael C Schmid, Ainhoa Mielgo
UNLABELLED: Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease, yet effective treatments to inhibit PDAC metastasis are lacking. The rich PDAC tumor microenvironment plays a major role in disease progression. Macrophages are the most abundant immune cell population in PDAC tumors and can acquire a range of functions that either hinder or promote tumor growth and metastasis. Here, we identified that mesothelin secretion by pancreatic cancer cells co-opts macrophages to support tumor growth and metastasis of cancer cells to the lungs, liver, and lymph nodes...
February 15, 2024: Cancer Research
https://read.qxmd.com/read/38356442/macrophages-under-the-influence-of-tumor-mesothelin-weaken-host-defenses-against-pancreatic-cancer-metastasis
#38
JOURNAL ARTICLE
Christine Alewine
Although pancreatic cancer is a systemic disease that metastasizes early in its course, the signaling systems that promote this behavior remain incompletely understood. In this issue of Cancer Research, Luckett and colleagues identify a paracrine signaling pathway between cancer cells and macrophages that promotes pancreatic cancer metastasis. The authors used immunocompetent murine pancreatic cancer models with high versus low metastatic potential, genetic knockout and complementation strategies, and The Cancer Genome Atlas human data to demonstrate that tumor-secreted mesothelin repolarizes tumor and lung macrophages to a tumor-supportive phenotype...
February 15, 2024: Cancer Research
https://read.qxmd.com/read/38351230/full-length-single-molecule-protein-fingerprinting
#39
JOURNAL ARTICLE
Mike Filius, Raman van Wee, Carlos de Lannoy, Ilja Westerlaken, Zeshi Li, Sung Hyun Kim, Cecilia de Agrela Pinto, Yunfei Wu, Geert-Jan Boons, Martin Pabst, Dick de Ridder, Chirlmin Joo
Proteins are the primary functional actors of the cell. While proteoform diversity is known to be highly biologically relevant, current protein analysis methods are of limited use for distinguishing proteoforms. Mass spectrometric methods, in particular, often provide only ambiguous information on post-translational modification sites, and sequences of co-existing modifications may not be resolved. Here we demonstrate fluorescence resonance energy transfer (FRET)-based single-molecule protein fingerprinting to map the location of individual amino acids and post-translational modifications within single full-length protein molecules...
February 13, 2024: Nature Nanotechnology
https://read.qxmd.com/read/38350817/role-of-diesel-exhaust-particle-induced-cellular-senescence-in-the-development-of-asthma-in-young-and-old-mice
#40
JOURNAL ARTICLE
Hyun Seung Lee, Heung-Woo Park
BACKGROUND: Although it has been reported that cellular senescence is important in the pathogenesis of asthma, the differential effects of diesel exhaust particle (DEP)-induced cellular senescence on the development of asthma according to age have not been thoroughly studied. METHODS: We first confirmed that DEP induced cellular senescence in mouse lungs, and then that DEP-induced cellular senescence followed by intranasal instillation of a low-dose house dust mite (HDM) allergen resulted in murine asthma...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
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