Roxane Gruel, Baukje Bijnens, Johanna Van Den Daele, Sofie Thys, Roland Willems, Dirk Wuyts, Debby Van Dam, Peter Verstraelen, Rosanne Verboven, Jana Roels, Niels Vandamme, Renzo Mancuso, Juan Diego Pita-Almenar, Winnok H De Vos
Long considered to fluctuate between pro- and anti-inflammatory states, it has now become evident that microglia occupy a variegated phenotypic landscape with relevance to aging and neurodegeneration. However, whether specific microglial subsets converge in or contribute to both processes that eventually affect brain function is less clear. To investigate this, we analyzed microglial heterogeneity in a tauopathy mouse model (K18-seeded P301L) and an accelerated aging model (Senescence-Accelerated Mouse-Prone 8, SAMP8) using cellular indexing of transcriptomes and epitopes by sequencing...
February 25, 2024: Aging Cell