keyword
MENU ▼
Read by QxMD icon Read
search

s100A9

keyword
https://www.readbyqxmd.com/read/27911324/proteomics-analysis-of-blood-serums-from-alzheimer-s-disease-patients-using-itraq-labeling-technology
#1
Liming Shen, Liping Liao, Cheng Chen, Yi Guo, Dalin Song, Yong Wang, Youjiao Chen, Kaoyuan Zhang, Ming Ying, Shuiming Li, Qiong Liu, Jiazuan Ni
Alzheimer' disease (AD) is the most common form of dementia affecting up to 6% of the population over the age of 65. In order to discover differentially expressed proteins that might serve as potential biomarkers, the serums from AD patients and healthy controls were compared and analyzed using the proteomics approach of isobaric tagging for relative and absolute quantitation (iTRAQ). For the first time, AD biomarkers in serums are investigated in the Han Chinese population using iTRAQ labeled proteomics strategy...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27895095/calprotectin-in-rheumatic-diseases
#2
Francesca Ometto, Lara Friso, Davide Astorri, Costantino Botsios, Bernd Raffeiner, Leonardo Punzi, Andrea Doria
Calprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils in the circulation and in inflamed tissues. The implication of calprotectin in the inflammatory process has already been demonstrated, but its role in the pathogenesis, diagnosis, and monitoring of rheumatic diseases has gained great attention in recent years. Calprotectin, being stable at room temperature, is a candidate biomarker for the follow-up of disease activity in many autoimmune disorders, where it can predict response to treatment or disease relapse...
November 28, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27849448/myeloid-related-protein-14-mrp-14-s100a9-calgranulin-b-is-associated-with-inflammation-in-proliferative-diabetic-retinopathy
#3
Ahmed M Abu El-Asrar, Kaiser Alam, Mohammad M Siddiquei, Kathleen Van den Eynde, Ghulam Mohammad, Gert De Hertogh, Ghislain Opdenakker
PURPOSE: To investigate the expression of the leukocyte proteins myeloid-related protein (MRP)-8 and MRP-14 in proliferative diabetic retinopathy (PDR) and the effect of MRP-8/MRP-14 (calprotectin) heterodimer on induction of proinflammatory factors in human retinal microvascular endothelial cells (HRMEC). METHODS: Epiretinal membranes from 20 patients with PDR and 10 patients with proliferative vitreoretinopathy (PVR), vitreous fluid samples from PDR and non-diabetic subjects and HRMEC were studied by immunohistochemistry and Western blot analysis...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27847095/proteomic-analysis-and-translational-perspective-of-hepatocellular-carcinoma-identification-of-diagnostic-protein-biomarkers-by-an-onco-proteogenomics-approach
#4
REVIEW
Shyh-Horng Chiou, King-Teh Lee
Hepatocellular carcinoma (HCC) has been ranked as the third leading cause of cancer-related mortality worldwide. Typically, patients are already in advanced stages of liver cirrhosis at the time of HCC diagnosis. Because HCC is often detected at a late stage and is highly aggressive, noninvasive biomarkers are urgently needed for early diagnosis. Recent advances in gene-expression profiling technologies have enabled molecular classification of HCC into defined subclasses that provide a firm basis for further study of potential mechanisms and biomarkers underlying the development of HCC...
November 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27808344/s100a9-induces-monocyte-macrophage-migration-via-emmprin
#5
Vasileia Ismini Alexaki, Andreas E May, Chika Fujii, Saskia N I V Ungern-Sternberg, Christine Mund, Meinrad Gawaz, Triantafyllos Chavakis, Peter Seizer
No abstract text is available yet for this article.
November 3, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27797827/anti-inflammatory-natural-product-goniothalamin-reduces-colitis-associated-and-sporadic-colorectal-tumorigenesis
#6
Débora Barbosa Vendramini-Costa, Ralph Francescone, David Posocco, Vivianty Hou, Oxana Dmitrieva, Harvey Hensley, João Ernesto de Carvalho, Ronaldo Aloise Pilli, Sergei Grivennikov
The tumor microenvironment offers multiple targets for cancer therapy, including pro-tumorigenic inflammation. Natural compounds represent an enormous source of new anti-inflammatory and anticancer agents. We previously showed that the styryl lactone goniothalamin (GTN) has promising antiproliferative and anti-inflammatory activities. Because inflammation is a major driver of colorectal cancer (CRC), we therefore evaluated the therapeutic and preventive potentials of GTN in colitis, colitis associated cancer (CAC) and spontaneous CRC...
October 24, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27793853/investigating-the-extremes-of-the-continuum-of-paracrine-functions-in-cd34-cd31-cacs-across-diverse-populations
#7
Rian Q Landers-Ramos, Ryan M Sapp, Emily VandeWater, Jennifer Macko, Shawn Robinson, Yan Wang, Eva R Chin, Espen E Spangenburg, Steven J Prior, James M Hagberg
Paracrine function of circulating angiogenic cells (CACs) is thought to contribute to vascular maintenance. We previously identified S100A8 and S100A9 secreted from physically inactive individuals' CD34-/CD31+ CACs as negative regulators of capillary-like network formation. The purpose of this study was to further investigate the extremes of the continuum of CAC paracrine actions using two distinctly different groups representing "healthy" and "impaired" CAC function. We aimed to determine how capillary-like network formation in human umbilical vein endothelial cells (HUVECs) is affected by S100A8 and S100A9 in concentrations secreted by CACs from different ends of the health spectrum...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27776554/s100a8-a9-a-potent-serum-and-molecular-imaging-biomarker-for-synovial-inflammation-and-joint-destruction-in-seronegative-experimental-arthritis
#8
Edwin J W Geven, Martijn H J van den Bosch, Irene Di Ceglie, Giuliana Ascone, Shahla Abdollahi-Roodsaz, Annet W Sloetjes, Sven Hermann, Michael Schäfers, Fons A J van de Loo, Peter M van der Kraan, Marije I Koenders, Dirk Foell, Johannes Roth, Thomas Vogl, Peter L E M van Lent
BACKGROUND: Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is released by activated phagocytes, and high levels are found in seronegative arthritides. In this study, we investigated the biomarker potential of systemic and local levels of these S100 proteins to assess joint inflammation and joint destruction in an experimental model for seronegative arthritis...
October 24, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27761284/evaluation-of-serum-s100a8-s100a9-levels-in-patients-with-autoimmune-thyroid-diseases
#9
Hakan Korkmaz, Suzan Tabur, Esen Savaş, Mesut Özkaya, Şefika Nur Aksoy, Nurten Aksoy, Ersin Akarsu
BACKGROUND: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD). AIMS: We aimed to evaluate the level of serum S100A8/S100A9 in AITD. STUDY DESIGN: Case control study. METHODS: Fifty patients with AITD (25 Hashimoto's thyroiditis (HT) and 25 Graves' disease (GD)) were included in the study...
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27759084/vildagliptin-and-its-metabolite-m20-7-induce-the-expression-of-s100a8-and-s100a9-in-human-hepatoma-hepg2-and-leukemia-hl-60-cells
#10
Mitsutoshi Asakura, Fumika Karaki, Hideaki Fujii, Koichiro Atsuda, Tomoo Itoh, Ryoichi Fujiwara
Vildagliptin is a potent, orally active inhibitor of dipeptidyl peptidase-4 (DPP-4) for the treatment of type 2 diabetes mellitus. It has been reported that vildagliptin can cause hepatic dysfunction in patients. However, the molecular-mechanism of vildagliptin-induced liver dysfunction has not been elucidated. In this study, we employed an expression microarray to determine hepatic genes that were highly regulated by vildagliptin in mice. We found that pro-inflammatory S100 calcium-binding protein (S100) a8 and S100a9 were induced more than 5-fold by vildagliptin in the mouse liver...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27749214/phagocyte-specific-s100a8-a9-is-upregulated-in-primary-sj%C3%A3-gren-s-syndrome-and-triggers-the-secretion-of-pro-inflammatory-cytokines-in-vitro
#11
Charles Nicaise, Laura Weischelbaum, Liliane Schandene, Valérie Gangji, Florence Dehavay, Joanna Bouchat, Benoît Balau, Thomas Vogl, Muhammad S Soyfoo
OBJECTIVES: To determine the role of S100A8/A9 in the pathogenesis of primary Sjögren's syndrome (pSS). METHODS: The serum levels of S100A8/A9 were determined in pSS patients and healthy controls by ELISA. The expression of S100A8/A9 in salivary glands was assessed by immunohistochemistry. The phenotype of S100A8+ and S100A9+ cells was identified using double immunofluorescence. The effects of S100A8/A9 on cytokine production by peripheral blood mononuclear cells (PBMCs) from pSS patients were determined in vitro by flow cytometry...
October 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27748581/evaluation-of-spectral-counting-for-relative-quantitation-of-proteoforms-in-top-down-proteomics
#12
Lucia Geis-Asteggiante, Suzanne Ostrand-Rosenberg, Catherine Fenselau, Nathan J Edwards
Spectral counting is a straightforward label-free quantitation strategy used in bottom-up proteomics workflows. The application of spectral counting in label-free top-down proteomics workflows can be similarly straightforward, but has not been applied as widely as quantitation by chromatographic peak areas or peak intensities. In this study, we evaluate spectral counting for quantitative comparisons in label-free top-down proteomics workflows by comparison with chromatographic peak areas and intensities. We tested these quantitation approaches by spiking standard proteins into a complex protein background and comparing relative quantitation by spectral counts with normalized chromatographic peak areas and peak intensities from deconvoluted extracted ion chromatograms of the spiked proteins...
October 17, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27737891/the-nlrp3-inflammasome-functions-as-a-driver-of-the-myelodysplastic-syndrome-phenotype
#13
Ashley A Basiorka, Kathy L McGraw, Erika A Eksioglu, Xianghong Chen, Joseph Johnson, Ling Zhang, Qing Zhang, Brittany A Irvine, Thomas Cluzeau, David A Sallman, Eric Padron, Rami Komrokji, Lubomir Sokol, Rebecca C Coll, Avril A B Robertson, Matthew A Cooper, John L Cleveland, Luke A O'Neill, Sheng Wei, Alan F List
Despite genetic heterogeneity, myelodysplastic syndromes (MDS) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDS is activation of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death. Independent of genotype, MDS hematopoietic stem/progenitor cells (HSPC) overexpress inflammasome proteins and manifest activated NLRP3 complexes that direct activation of caspase-1, generation of IL-1β and IL-18 and pyroptotic cell death. Mechanistically, pyroptosis is triggered by the alarmin S100A9 that is found in excess in MDS HSPC and bone marrow plasma...
October 13, 2016: Blood
https://www.readbyqxmd.com/read/27725631/cancer-associated-fibroblast-secreted-cxcl16-attracts-monocytes-to-promote-stroma-activation-in-triple-negative-breast-cancers
#14
Roni Allaoui, Caroline Bergenfelz, Sofie Mohlin, Catharina Hagerling, Kiarash Salari, Zena Werb, Robin L Anderson, Stephen P Ethier, Karin Jirström, Sven Påhlman, Daniel Bexell, Balázs Tahin, Martin E Johansson, Christer Larsson, Karin Leandersson
Triple-negative (TN) breast cancers (ER(-)PR(-)HER2(-)) are highly metastatic and associated with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of inflammatory cells are even more aggressive. The effect of myeloid cells on reactive stroma formation in TN breast cancer is largely unknown. Here, we show that primary human monocytes have a survival advantage, proliferate in vivo and develop into immunosuppressive myeloid cells expressing the myeloid-derived suppressor cell marker S100A9 only in a TN breast cancer environment...
October 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27706811/oncogenic-targets-mmp7-s100a9-nppb-and-aldh1a3-from-transcriptome-profiling-of-fap-and-pirc-adenomas-are-downregulated-in-response-to-tumor-suppression-by-clotam
#15
Furkan U Ertem, Wenqian Zhang, Kyle Chang, Wan Mohaiza Dashwood, Praveen Rajendran, Deqiang Sun, Ala Abudayyeh, Eduardo Vilar, Maen Abdelrahim, Roderick H Dashwood
Intervention strategies in familial adenomatous polyposis (FAP) patients and other high-risk colorectal cancer (CRC) populations have highlighted a critical need for endoscopy combined with safe and effective preventive agents. We performed transcriptome profiling of colorectal adenomas from FAP patients and the polyposis in rat colon (Pirc) preclinical model, and prioritized molecular targets for prevention studies in vivo. At clinically relevant doses in the Pirc model, the drug Clotam (tolfenamic acid, TA) was highly effective at suppressing tumorigenesis both in the colon and in the small intestine, when administered alone or in combination with Sulindac...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27698489/upregulation-of-angptl6-in-mouse-keratinocytes-enhances-susceptibility-to-psoriasis
#16
Hiroki Tanigawa, Keishi Miyata, Zhe Tian, Jun Aoi, Tsuyoshi Kadomatsu, Satoshi Fukushima, Aki Ogata, Naoki Takeda, Jiabin Zhao, Shunshun Zhu, Kazutoyo Terada, Motoyoshi Endo, Jun Morinaga, Taichi Sugizaki, Michio Sato, Masaki Suimye Morioka, Ichiro Manabe, Youichi Mashimo, Akira Hata, Yoshitaka Taketomi, Kei Yamamoto, Makoto Murakami, Kimi Araki, Masatoshi Jinnin, Hironobu Ihn, Yuichi Oike
Psoriasis is a chronic inflammatory skin disease marked by aberrant tissue repair. Mutant mice modeling psoriasis skin characteristics have provided useful information relevant to molecular mechanisms and could serve to evaluate therapeutic strategies. Here, we found that epidermal ANGPTL6 expression was markedly induced during tissue repair in mice. Analysis of mice overexpressing ANGPTL6 in keratinocytes (K14-Angptl6 Tg mice) revealed that epidermal ANGPTL6 activity promotes aberrant epidermal barrier function due to hyperproliferation of prematurely differentiated keratinocytes...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27696741/inflammatory-gene-expression-profile-and-defective-ifn-%C3%AE-and-granzyme-k-in-natural-killer-cells-of-systemic-juvenile-idiopathic-arthritis-patients
#17
Karen Put, Jessica Vandenhaute, Anneleen Avau, Annemarie Van Nieuwenhuijze, Ellen Brisse, Tim Dierckx, Omer Rutgeerts, Josselyn Garcia-Perez, Jaan Toelen, Mark Waer, Georges Leclercq, An Goris, Johan Van Weyenbergh, Adrian Liston, Lien de Somer, Carine Wouters, Patrick Matthys
OBJECTIVE: Systemic juvenile idiopathic arthritis (sJIA) is an immune-inflammatory disease characterized by arthritis and systemic features. The role of natural killer (NK) cells in sJIA pathogenesis remains unclear. Therefore, we performed a comprehensive analysis of NK cell phenotype and functionality in sJIA patients. METHODS: NK cell-specific transcriptional alterations were investigated by RNA-sequencing of highly purified NK cells from six active sJIA patients and six healthy controls...
October 1, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27696085/transcriptomic-effects-of-adenosine-2a-receptor-deletion-in-healthy-and-endotoxemic-murine-myocardium
#18
Kevin J Ashton, Melissa E Reichelt, S Jamal Mustafa, Bunyen Teng, Catherine Ledent, Lea M D Delbridge, Polly A Hofmann, R Ray Morrison, John P Headrick
Influences of adenosine 2A receptor (A2AR) activity on the cardiac transcriptome and genesis of endotoxemic myocarditis are unclear. We applied transcriptomic profiling (39 K Affymetrix arrays) to identify A2AR-sensitive molecules, revealed by receptor knockout (KO), in healthy and endotoxemic hearts. Baseline cardiac function was unaltered and only 37 A2AR-sensitive genes modified by A2AR KO (≥1.2-fold change, <5 % FDR); the five most induced are Mtr, Ppbp, Chac1, Ctsk and Cnpy2 and the five most repressed are Hp, Yipf4, Acta1, Cidec and Map3k2...
September 30, 2016: Purinergic Signalling
https://www.readbyqxmd.com/read/27693389/enzyme-linked-immunosorbent-assay-for-s100a9-in-the-stool-of-rats-with-dextran-sulfate-sodium-induced-colitis
#19
Shunsuke Sekiya, Makoto Murata, Satoshi Arai, Hiroshi Murayama, Atushi Kawasaki, Noriyuki Ashida, Kohki Okada, Masaki Ikemoto
Calprotectin, a heterodimer of S100A8 and S100A9, has been reported to be a useful biomarker in inflammatory bowel disease (IBD); however, the relationship between the fecal level of S100A9 and the extent of inflammation in IBD remains unclear. Our aim was to develop a new enzyme-linked immunosorbent assay (ELISA) for rat S100A9, and to investigate whether changes in fecal S100A9 levels reflect the inflammatory conditions in the intestinal tracts of rats with dextran sulfate sodium (DSS)-induced colitis. Anti-rat S100A9 monoclonal antibodies were raised in mice and used for the development of a novel ELISA for rat S100A9...
September 28, 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27689623/alarmins-and-clinical-outcomes-after-major-abdominal-surgery-a-prospective-study
#20
Jan Máca, Filip Burša, Pavel Ševčík, Peter Sklienka, Michal Burda, Michal Holub
PURPOSE: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes. MATERIALS AND METHODS: We analyzed serum levels of alarmins, including S100A5, S100A6, S100A8, S100A9, S100A11, and S100A12; high-mobility group box 1; and heat-shock protein 70, after elective major abdominal surgery (n = 82). Blood samples were collected for three consecutive days after surgery...
September 30, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
keyword
keyword
61968
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"