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https://www.readbyqxmd.com/read/28346858/circulating-soluble-il-6-receptor-concentration-and-visceral-adipocyte-size-are-related-to-insulin-resistance-in-taiwanese-adults-with-morbid-obesity
#1
Feng-Chih Kuo, Ya-Hsien Huang, Fu-Huang Lin, Yi-Jen Hung, Chang-Hsun Hsieh, Chieh-Hua Lu, Sheng-Chiang Su, Chia-Luen Huang, Chien-Hsing Lee, Nain-Feng Chu
BACKGROUND: Morbid obesity is related to chronic inflammation and many metabolic complications. Interleukin (IL)-6 plays a pivotal pathophysiological role in obesity, and IL-6 trans-signaling through the soluble IL-6 receptor (sIL-6R) has a major proinflammatory effect. The aim of this study was to investigate the association between sIL-6R, adipocyte size, and insulin resistance in morbidly obese individuals. METHODS: We measured concentrations of sIL-6R, high-sensitivity C-reactive protein, and lipid parameters and estimated homeostasis model assessment of insulin resistance (HOMA-IR) before the patients underwent bariatric surgery...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28345810/an-untrodden-path-versatile-fabrication-of-self-supporting-polymer-stabilized-percolation-membranes-pspms-for-gas-separation
#2
Sebastian Friebe, Alexander Mundstock, Daniel Schneider, Jürgen Caro
The preparation and scalability of zeolite or MOF membranes remains a major challenge, thus preventing the application of these materials in large-scale gas separation. Additionally, several zeolite or MOF materials are quite difficult or nearly impossible to grow as defect-free layers and require expensive macroporous ceramic or polymer supports. Here, we present a new approach for self-supporting zeolite and MOF composite membranes, called Polymer-Stabilized Percolation Membranes (PSPMs) consisting of a pressed gas selective percolation network - in our case ZIF-8, NaX and MIL-140 - and a gas impermeable infiltrated epoxy resin for cohesion...
March 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28340732/glycine-post-synthetic-modification-of-mil-53-fe-metal-organic-framework-with-enhanced-and-stable-peroxidase-like-activity-for-sensitive-glucose-biosensing
#3
Wenfei Dong, Liaoyuan Yang, Yuming Huang
A facile and rapid post-synthetic strategy was proposed to prepare a glycine functionalized MIL-53(Fe), namely glycine-MIL-53(Fe), by a simple mixing of water dispersible MIL-53(Fe) and glycine. The FT-IR, SEM, XRD and zeta potential were used to characterize the glycine-MIL-53(Fe). The result showed that glycine post-synthetic modification of MIL-53(Fe) did not change in the morphology and crystal structure of MIL-53(Fe). Interestingly, compared with MIL-53(Fe), the glycine-MIL-53(Fe) exhibits an enhanced peroxidase-like activity, which could catalyze the oxidation of TMB by H2O2 to produce an intensive color reaction...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340720/headspace-single-drop-microextraction-versus-dispersive-liquid-liquid-microextraction-using-magnetic-ionic-liquid-extraction-solvents
#4
Jiwoo An, Kira L Rahn, Jared L Anderson
A headspace single drop microextraction (HS-SDME) method and a dispersive liquid-liquid microextraction (DLLME) method were developed using two tetrachloromanganate ([MnCl4(2-)])-based magnetic ionic liquids (MIL) as extraction solvents for the determination of twelve aromatic compounds, including four polyaromatic hydrocarbons, by reversed phase high-performance liquid chromatography (HPLC). The analytical performance of the developed HS-SDME method was compared to the DLLME approach employing the same MILs...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28334987/magnetic-solid-phase-extraction-of-n-n-diethyl-m-toluamide-from-baby-toilet-water-prior-to-its-hplc-uv-detection
#5
Xiaowei Ma, Fan Feng, Yang Yang, Xueping Dang, Jianlin Huang, Huaixia Chen
Fe3O4@MIL-100 (MIL, Material Institut Lavoisier) core-shell magnetic microspheres were prepared and applied as the sorbent for the magnetic solid phase extraction (MSPE) of N,N-diethyl-m-toluamide (DEET) in baby toilet water for the first time. The synthesized magnetic metal-organic frameworks were characterized by transmission electron microscope, infrared spectroscopy and thermogravimetric analysis. The functionalized magnetic microparticles showed excellent dispersibility in aqueous solution. The MSPE conditions were investigated in detail...
March 3, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28334522/microwave-assisted-morphology-evolution-of-fe-based-metal-organic-frameworks-and-their-derived-fe2o3-nanostructures-for-li-ion-storage
#6
Wenxiang Guo, Weiwei Sun, Li-Ping Lv, Shaofeng Kong, Yong Wang
The metal-organic-framework (MOF) approach is demonstrated as an effective strategy for the morphology evolution control of MIL-53(Fe) with assistance of microwave irradiation. Owing to the homogeneous nucleation offered by microwave irradiation and confined porosity and skeleton by MOF templates, various porous Fe2O3 nanostructures including spindle, concave octahedron, solid octahedron, yolk-shell octahedron, and nanorod with porosity control are derived by simply adjusting the irradiation time. The formation mechanism for the MOF precursors and their derived iron oxides with morphology control is investigated...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28334498/multi-shelled-hollow-metal-organic-frameworks
#7
Wenxian Liu, Jijiang Huang, Qiu Yang, Shiji Wang, Xiaoming Sun, Weina Zhang, Junfeng Liu, Fengwei Huo
Hollow metal-organic frameworks (MOFs) are promising materials with sophisticated structures, such as multiple shells, that cannot only enhance the properties of MOFs but also endow them with new functions. Herein, we show a rational strategy to fabricate multi-shelled hollow chromium (III) terephthalate MOFs (MIL-101) with single-crystalline shells through step-by-step crystal growth and subsequent etching processes. This strategy relies on the creation of inhomogeneous MOF crystals in which the outer layer is chemically more robust than the inner layer and can be selectively etched by acetic acid...
March 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28334224/computational-modeling-of-in-vivo-and-in-vitro-protein-dna-interactions-by-multiple-instance-learning
#8
Zhen Gao, Jianhua Ruan
Motivation: The study of transcriptional regulation is still difficult yet fundamental in molecular biology research. While the development of both in vivo and in vitro profiling techniques have significantly enhanced our knowledge of transcription factor (TF)-DNA interactions, computational models of TF-DNA interactions are relatively simple and may not reveal sufficient biological insight. In particular, supervised learning based models for TF-DNA interactions attempt to map sequence-level features ( k -mers) to binding event but usually ignore the location of k -mers, which can cause data fragmentation and consequently inferior model performance...
March 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28321248/patch-based-multiple-instance-learning-algorithm-for-object-tracking
#9
Zhenjie Wang, Lijia Wang, Hua Zhang
To deal with the problems of illumination changes or pose variations and serious partial occlusion, patch based multiple instance learning (P-MIL) algorithm is proposed. The algorithm divides an object into many blocks. Then, the online MIL algorithm is applied on each block for obtaining strong classifier. The algorithm takes account of both the average classification score and classification scores of all the blocks for detecting the object. In particular, compared with the whole object based MIL algorithm, the P-MIL algorithm detects the object according to the unoccluded patches when partial occlusion occurs...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28317968/ag-induced-photoluminescence-enhancement-in-lanthanide-post-functionalized-mofs-and-ag-sensing
#10
Nana Sun, Bing Yan
The robust gallium carboxylate Ga(OH)(btec)·0.5H2O (MIL-61) is selected as a parent MOF to prepare Ln-MIL-61 by PSM. This work investigates the luminescence of Ln-doped MIL-61 (Ln = Eu(3+), Tb(3+), Sm(3+), Dy(3+)) in the visible light region. Upon 314 nm excitation, the emission spectra of Eu-MIL-61, Tb-MIL-61 and Eu/Tb-MIL-61 all exhibit their respective strong sharp emission bands. However, Sm-MIL-61 and Dy-MIL-61 show very similar emission to MIL-61 and almost no luminescence of Sm(3+) and Dy(3+). In this work, the weak fluorescence of Sm(3+) or Dy(3+) doped MIL-61 is effectively sensitized by Ag(+)...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28300048/cardiovascular-responses-to-millet-pounding-activity-among-women-in-a-rural-community-in-northeastern-nigeria
#11
Adetoyeje Y Oyeyemi, Fati Jajimaji, Adewale L Oyeyemi, Abdul-Hameed A Jabbo
BACKGROUND: Pounding food items in a wooden mortal is a common home chore in many communities in African and Asian countries. However, no empirical data exist on energy expenditure during this activity, and whether the activity can be considered a light, moderate, or vigorous intensity physical activity is unknown. PURPOSE: This study was aimed at gaining insights into energy expenditure during millet pounding through cardiovascular responses to millet pounding activity, and to explore possible differences in response between women who pound millet as their occupation (habitual millet pounders) and those who pound millet only for their own home cooking but not as a job (nonhabitual pounders)...
January 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28298332/impact-of-lifelong-exercise-training-on-endothelial-ischemia-reperfusion-and-ischemic-preconditioning-in-humans
#12
Martijn F H Maessen, Anke Ccm van Mil, Yaïra Straathof, Niels P Riksen, Gerard A P J M Rongen, Maria T E Hopman, Thijs M H Eijsvogels, Dick H J Thijssen
Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28291447/an-orthopedic-performance-improvement-initiative-at-a-small-military-treatment-facility
#13
John Christopher McGee, Christopher G Bise, Joel M Stevens
OBJECTIVES: The scientific literature demonstrates a cost-benefit associated with early access to physical therapy. The purpose of this case study is to report the results of an orthopedic performance improvement initiative (OPII) at a small military treatment facility (approximately 4.5K active duty beneficiaries). The OPII was introduced to (1) limit variation by ensuring that all active duty orthopedic consults were audited ensuring proper timing of appropriate services and (2) establish contractual agreement for shared resources with the U...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290137/sarilumab-first-global-approval
#14
Lesley J Scott
Sarilumab (Kevzara™) is a fully human IgG1 monoclonal antibody that binds specifically to both soluble and membrane-bound interleukin (IL)-6 receptors (sIL-6Rα and mIL-6Rα) and thereby inhibits IL-6-mediated signalling through these receptors. Subcutaneous sarilumab is approved in Canada for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more biological or non-biological disease-modifying anti-rheumatic drugs. It is under regulatory review for use in rheumatoid arthritis in other countries, including in the EU, USA and Japan...
March 13, 2017: Drugs
https://www.readbyqxmd.com/read/28286349/re-determination-of-the-crystal-structure-of-mil-91-al
#15
Nele Hermer, Michael T Wharmby, Norbert Stock
The structure of one of the first permanently porous metal phosphonates, MIL-91(Al) was re-determined using high resolution synchrotron powder X-ray diffraction data. The new model is in a lower symmetry space group, with no disordered ligands in the structure, whilst remaining otherwise consistent with the reported compound. New milder synthetic conditions were also developed.
January 2017: Zeitschrift Für Anorganische und Allgemeine Chemie
https://www.readbyqxmd.com/read/28284332/confirmed-case-of-levamisole-associated-multifocal-inflammatory-leukoencephalopathy-in-a-cocaine-user
#16
Jeffrey R Vitt, Ethan G Brown, Daniel S Chow, S Andrew Josephson
Levamisole is a common adulterant in cocaine and has previously been associated with a variety of serious complications including multifocal inflammatory leukoencephalopathy (MIL). There have been several reports of MIL in patients taking cocaine and, though suspected, the presence of levamisole was not confirmed. We present a case of a 63-year-old woman presenting with stupor and spastic quadraparesis found to have urine positive for cocaine and levamisole. An MRI brain revealed innumerable FLAIR hyperintensities with restricted diffusion and incomplete ring-enhancement...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28283528/rheumatoid-arthritis-phenotype-at-presentation-differs-depending-on-the-number-of-autoantibodies-present
#17
V F A M Derksen, S Ajeganova, L A Trouw, A H M van der Helm-van Mil, I Hafström, T W J Huizinga, R E M Toes, B Svensson, D van der Woude
OBJECTIVES: In rheumatoid arthritis (RA), seropositive and seronegative disease may be two entities with different underlying pathophysiological mechanisms, long-term outcomes and disease presentations. However, the effect of the conjoint presence of multiple autoantibodies, as proxy for a more pronounced humoral autoimmune response, on clinical phenotype remains unclear. Therefore, this study investigates the association between the number of autoantibodies and initial clinical presentation in two independent cohorts of patients with early RA...
April 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28275829/endothelial-nitric-oxide-synthase-in-rat-brain-is-downregulated-by-sub-chronic-antidepressant-treatment
#18
Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Shunsuke Nakata, Jun-Ichi Iga, Shu-Ichi Ueno
BACKGROUND: Nitric oxide (NO) is a neurotransmitter that may be related to major depressive disorder (MDD) because the selective neuronal NO synthase (NOS) inhibitor, 7-nitroindazole, induces a dose-dependent antidepressant-like effect. NO modulates major neurotransmitters involved in the neurobiology of MDD, such as norepinephrine, serotonin, dopamine, and glutamate. In this study, we investigated the effects of antidepressants as NO modulators in acute and sub-chronic treatments. METHODS: Rats were injected with the SSRI paroxetine (PAR, 10 mg/kg), the SNRI milnacipran (MIL, 30 mg/kg), or the NaSSA mirtazapine (MIR, 10 mg/kg) for acute (1 h) or sub-chronic (3 weeks) treatment prior to analysis of nine brain regions (frontal cortex, temporal cortex, striatum, thalamus, hippocampus, midbrain, pons, cerebellum, and olfactory bulb)...
March 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28271874/highly-efficient-catalytic-hydrogen-evolution-from-ammonia-borane-using-the-synergistic-effect-of-crystallinity-and-size-of-noble-metal-free-nanoparticles-supported-by-porous-metal-organic-frameworks
#19
Penglong Liu, Xiaojun Gu, Kai Kang, Hao Zhang, Jia Cheng, Haiquan Su
A series of nonprecious metal nanoparticles (NPs) supported by metal-organic framework MIL-101 were synthesized using four methods and their catalytic performance on hydrogen evolution from ammonia borane (NH3BH3) was studied. The results showed that the crystalline Co NPs with size of 4.5-8.5 and 14.5-24.5 nm had low activities featuring the total turnover frequency (TOF) values of 9.9 and 4.5 molH2 molcat(-1) min(-1), respectively. In contrast, the amorphous Co NPs with size of 1.6-2.6 and 13.5-24.5 nm exhibited high activities featuring the total TOF values of 51...
March 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28268438/heart-beat-characterization-from-ballistocardiogram-signals-using-extended-functions-of-multiple-instances
#20
Changzhe Jiao, Princess Lyons, Alina Zare, Licet Rosales, Marjorie Skubic
A multiple instance learning (MIL) method, extended Function of Multiple Instances (eFUMI), is applied to ballistocardiogram (BCG) signals produced by a hydraulic bed sensor. The goal of this approach is to learn a personalized heartbeat "concept" for an individual. This heartbeat concept is a prototype (or "signature") that characterizes the heartbeat pattern for an individual in ballistocardiogram data. The eFUMI method models the problem of learning a heartbeat concept from a BCG signal as a MIL problem...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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