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Sandro R Freitas, João Marmeleira, Maria João Valamatos, Anthony Blazevich, Pedro Mil-Homens
OBJECTIVES: Biceps femoris long-head architectural assessment using ultrasonography (US) has not been previously described in detail for both acquisition (image capture) and digitization (image measurement) processes, and the effect of the US window width is unknown. This study aimed to describe the reliability and test-retest minimum detectable difference of US-based biceps femoris architectural measurements. METHODS: Muscle length was determined by marking the muscle-tendon junction distances...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Sérgio M F Vilela, Pablo Salcedo-Abraira, Isabelle Colinet, Fabrice Salles, Martijn C de Koning, Marloes J A Joosen, Christian Serre, Patricia Horcajada
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH₂ (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the first time it could be considered for encapsulation and the release of drugs. The nerve agent antidote 2-[(hydroxyimino)methyl]-1-methyl-pyridinium chloride (2-PAM or pralidoxime) was effectively encapsulated into the pores of MIL-125-NH₂ as a result of the interactions between 2-PAM and the pore walls being mediated by π-stacking and hydrogen bonds, as deduced from infrared spectroscopy and Monte Carlo simulation studies...
October 12, 2017: Nanomaterials
Liliana O Silva, Lígia S Nobre, Dalila Mil-Homens, Arsénio Fialho, Lígia M Saraiva
No abstract text is available yet for this article.
October 11, 2017: Virulence
Heidi A Schwartz, Selina Olthof, Dominik Schaniel, Klaus Meerholz, Uwe Ruschewitz
1,3,3-Trimethylindolino-6'-nitrobenzopyrylospiran (SP-1) as an example of a photoswitchable spiropyran was loaded into the pores of different prototypical metal-organic frameworks, namely MOF-5, MIL-68(In), and MIL-68(Ga), by a vapor-phase process. The successful incorporation in the pores of the MOF was proven by X-ray powder diffraction, and the amount of the embedded photoswitchable guest was determined by X-ray photoelectron spectroscopy and elemental analysis. In contrast to the sterically hindered crystalline state, SP-1 embedded in solid MOF hosts shows photoswitching under irradiation with UV light from the spiropyran to its merocyanine form with a nearly complete photoisomerization...
October 11, 2017: Inorganic Chemistry
Tilman Maurer, Andreas Metzner, S Yen Ho, Peter Wohlmuth, Bruno Reißmann, Christian Heeger, Christine Lemes, Kentaro Hayashi, Ardan M Saguner, Johannes Riedl, Christian Sohns, Shibu Mathew, Karl-Heinz Kuck, Erik Wissner, Feifan Ouyang
BACKGROUND: The mitral isthmus is a critical part of perimitral reentrant tachycardia, as well as an important substrate of persistent atrial fibrillation. Deployment of an endocardial mitral isthmus line (MIL) with the end point of bidirectional block may be challenging and often requires additional epicardial ablation within the coronary sinus. METHODS AND RESULTS: The study population comprised 114 patients with perimitral flutter who underwent de novo ablation of an MIL...
October 2017: Circulation. Arrhythmia and Electrophysiology
Vasudeva Rao Bakuru, Suresh Babu Kalidindi
Enhancing catalytic performance of metal nanoparticles is highly sought for many industrial catalytic processes. In this regard, assembling of crystalline porous super-tunable metal-organic frameworks (MOFs) around preformed metal nanoparticles is an attractive prospect as this strongly influences the activity of the entire nanoparticle surface. Herein, we assembled MlL-101(Fe) MOF onto the Pd nanocubes and evaluated the catalytic properties of the hybrid material using hydrogenation of variety of α,β-unsaturated carbonyl compounds; namely cinnamaldehyde, crotanaldehyde and β-ionone...
October 9, 2017: Chemistry: a European Journal
Zhongmin Liu, Jitao Chen, Yongchuan Wu, Yaru Li, Jingyu Zhao, Ping Na
A calcination time regulation method has been unprecedentedly used to adjust the orderly meso-structure of novel α-Fe2O3 nanoclusters derived from MIL-100(Fe) (MIL: Materials of Institute Lavoisier). The as-synthesized magnetic orderly mesoporous α-Fe2O3 nanoclusters were characterized by XRD, SEM, TEM, TGA, N2 adsorption-desorption isotherms, VSM, Zeta potential, FTIR and XPS. The 6h calcinated α-Fe2O3 nanocluster exhibited the optimal properties, including the high specific surface area and the orderly mesoporous properties, which facilitate the arsenic(III,V) adsorption capacity...
September 28, 2017: Journal of Hazardous Materials
Vittoria Massafra, Saskia van Mil
The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). BAs are amphipathic molecules that serve as fat solubilizers in the intestine under postprandial conditions. In the post-absorptive state, BAs bind FXR in the hepatocytes, which in turn provides feedback signals on BA synthesis and transport and regulates lipid, glucose and amino acid metabolism. Therefore, FXR acts as a homeostat of all three classes of nutrients, fats, sugars and proteins. Here we re-analyze the function of FXR in the perspective of nutritional metabolism, and discuss the role of FXR in liver energy homeostasis in postprandial, post-absorptive and fasting/starvation states...
October 3, 2017: Biochimica et Biophysica Acta
Mohammad Arifur Rahman, Nathan LaPierre, Huzefa Rangwala
The recent advent of Metagenome Wide Association Studies (MGWAS) provides insight into the role of microbes on human health and disease. However, the studies present several computational challenges. In this paper we demonstrate a novel, efficient, and effective Multiple Instance Learning (MIL) based computational pipeline to predict patient phenotype from metagenomic data. MIL methods have the advantage that besides predicting the clinical phenotype, we can infer the instance level label or role of microbial sequence reads in the specific disease...
October 4, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Muder Al Haydar, Hussein Rasool Abid, Bruce Sunderland, Shaobin Wang
BACKGROUND: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. PURPOSE: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery...
2017: Drug Design, Development and Therapy
Robin M Ten Brinck, Hanna W van Steenbergen, Myrthe A M van Delft, Marije K Verheul, Rene E M Toes, Leendert A Trouw, Annette H M van der Helm-van Mil
Objectives: Autoantibody testing is helpful for predicting the risk of progression to clinical arthritis in subjects at risk. Previous longitudinal studies have mainly selected autoantibody-positive arthralgia patients, and consequently the predictive values of autoantibodies were evaluated relative to one another. This study assessed the risks for arthritis development of ACPA, RF and/or anti-carbamylated protein antibodies (anti-CarP) in arthralgia patients considered at risk for RA by rheumatologists, based on clinical characteristics (clinically suspect arthralgia, CSA)...
September 11, 2017: Rheumatology
Leonie E Burgers, Filip Siljehult, Robin M Ten Brinck, Hanna W van Steenbergen, Robert B M Landewé, Solbritt Rantapää-Dahlqvist, Annette H M van der Helm-van Mil
Objectives: Recently a EULAR-taskforce defined arthralgia suspicious for progression to RA, in order to allow inclusion of homogeneous sets of arthralgia patients in clinical studies. This longitudinal study aimed (i) to validate this definition in arthralgia patients in whom rheumatologists felt that imminent RA was more likely than other arthralgias [clinically suspect arthralgia (CSA)], that is, the target population fulfilling the entry criterion, and (ii) to explore the performance in arthralgia patients who were referred to secondary care prior to rheumatological evaluation, hence ignoring the entry criterion...
August 31, 2017: Rheumatology
Duc Thanh Nguyen, Philip O Ogunbona, Wanqing Li, Elizabeth Tasker, John Yearwood
Ground parrot vocalisation can be considered as an audio event. Test-based diverse density multiple instance learning (TB-DD-MIL) is proposed for detecting this event in audio files recorded in the field. The proposed method is motivated by the advantages of multiple instance learning from incomplete training data. Spectral features suitable for encoding the vocal source information of the ground parrot vocalization are also investigated. The proposed method was benchmarked against a dataset collected in various environmental conditions and an audio detection evaluation scheme is proposed...
September 2017: Journal of the Acoustical Society of America
Aleid C Boer, Leonie E Burgers, Lukas Mangnus, Robin M Ten Brinck, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Monique Reijnierse, Tom W J Huizinga, Annette H M van der Helm van Mil
Objectives: The use of hand and foot MRI in the diagnostic process of RA has been advocated. Recent studies showed that MRI is helpful in predicting progression from clinically suspect arthralgia (CSA) to clinical arthritis, and from undifferentiated arthritis (UA) to RA. Symptom-free persons can also show inflammation on MRI. This study aimed to evaluate if MRI findings in symptom-free volunteers are relevant when defining a positive MRI. Methods: Two hundred and twenty-five CSA patients and two hundred and one UA patients underwent MRI of MCP, wrist and MTP joints at baseline and were followed for 1 year on progression to arthritis and RA, respectively, as reported previously...
October 1, 2017: Rheumatology
Kirill Titov, Zhixin Zeng, Matthew R Ryder, Abhijeet Chaudhari, Bartolomeo Civalleri, Chris S Kelley, Mark D Frogley, Gianfelice Cinque, Jin-Chong Tan
Emerging nanoporous materials, such as metal-organic frameworks (MOFs), are promising low-k dielectrics central to next-generation electronics and high-speed communication. Hitherto, the dielectric characterization of MOFs is scarce, with very limited experimental data for guiding new materials design and synthesis. Herein we demonstrate the efficacy of high-resolution synchrotron infrared (IR) specular reflectance experiments, to study the dynamic dielectric properties of a flexible MOF structure: bi-stable MIL-53(Al) that exhibits switching between a large pore (LP) and a narrow pore (NP) architecture...
September 27, 2017: Journal of Physical Chemistry Letters
Laetitia Bullot, Ludivine Vieira-Sellaï, Gérald Chaplais, Angélique Simon-Masseron, Toufic Jean Daou, Joël Patarin, Emmanuel Fiani
This work aims to highlight the promising adsorption capacity and kinetic of (poly)chlorobenzene pollutants in the hybrid MIL-101(Cr) type material for technological uses in industrial waste exhaust decontamination. The influence of the MIL-101(Cr) crystal size (nano- and microcrystals) on the adsorption behavior was studied in static and dynamic modes. For this purpose, crystals of MIL-101(Cr) in nano- and micrometric sizes were synthesized and fully characterized. Their sorption properties regarding 1,2-dichlorobenzene were examined using gravimetric method in dynamic (p/p° = 0...
September 26, 2017: Environmental Science and Pollution Research International
Zhiliang Jin, Jing Fan, Yajuan Zhang, Yongxiang Yi, Lili Wang, Dandan Yin, Tao Deng, Wei Ye
Dendritic cells (DCs) as professional antigen presenting cells, are important in the initiation of the primary immune response. The present study compared the morphology, phenotypes and function between monocyte‑derived human DCs produced from a conventional culturing system containing granulocyte‑macrophage colony‑stimulating factor (GM‑CSF) and IL‑4 (IL‑4‑DC) and DCs generated by the stimulation of GM‑CSF and interferon (IFN)‑α (IFN‑DC). When compared with IL‑4‑DC in morphology, IFN‑DC contained more organelles, including endoplasmic reticulum and myelin figures, whereas mature (m)IL‑4‑DC contained more vacuoles in the cells...
September 21, 2017: Molecular Medicine Reports
Lucas R Parent, C Huy Pham, Joseph P Patterson, Michael S Denny, Seth M Cohen, Nathan C Gianneschi, Francesco Paesani
Metal-organic frameworks (MOFs) have emerged as a versatile platform for the rational design of multifunctional materials, combining large specific surface areas with flexible, periodic frameworks that can undergo reversible structural transitions, or "breathing", upon temperature and pressure changes, and through gas adsorption/desorption processes. Although MOF breathing can be inferred from the analysis of adsorption isotherms, direct observation of the structural transitions has been lacking, and the underlying processes of framework reorganization in individual MOF nanocrystals is largely unknown...
October 11, 2017: Journal of the American Chemical Society
Şahika Sena Bayazit, Selen Tuğba Danalıoğlu, Mohamed Abdel Salam, Özge Kerkez Kuyumcu
Metal organic frameworks are widely used as adsorbent materials in recent years. In this study, the most prepared metal organic framework MIL-101 was prepared by hydrothermal method and featured magnetic property using co-precipitation method Fe3O4. Then, the prepared composite (MIL-101/Fe3O4) was first characterized using XRD, FTIR, SEM-EDS, and surface area analysis, then was used for the adsorptive removal of the most used antibiotic, ciprofloxacin (CIP). The effect of different adsorption variables which may affect the removal of CIP by MIL-101/Fe3O4 was investigated, as well as their adsorbent quantity, initial CIP concentration, pH, temperature, and contact time...
September 21, 2017: Environmental Science and Pollution Research International
Zhujun Zhang, Shiliang Zhang, Qilu Yao, Xiangshu Chen, Zhang-Hui Lu
The catalytic dehydrogenation of hydrazine borane (N2H4BH3) and hydrous hydrazine (N2H4·H2O) for H2 evolution is considered as two of the pivotal reactions for the implementation of the hydrogen-based economy. A reduction rate controlled strategy is successfully applied for the encapsulating of uniform tiny NiPt alloy nanoclusters within the opening porous channels of MOFs in this work. The resultant Ni0.9Pt0.1/MOF core-shell composite with a low Pt content exerted exceedingly high activity and durability for complete H2 evolution (100% hydrogen selectivity) from alkaline N2H4BH3 and N2H4·H2O solution...
October 2, 2017: Inorganic Chemistry
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