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Yue Zhang, Bryan E G Lucier, Victor V Terskikh, Renlong Zheng, Yining Huang
Ga-MIL-53 is a metal-organic framework (MOF) that exhibits a "breathing effect," in which the pore size and overall MOF topology can be influenced by temperature, pressure, and host-guest interactions. The phase control afforded by this flexible framework renders Ga-MIL-53 a promising material for guest storage and sensing applications. In this work, the structure and behavior of four Ga-MIL-53 phases (as, ht, enp and lt), along with CO2 adsorbed within Ga-MIL-53 at various loading levels, has been investigated using (69/71)Ga solid-state NMR (SSNMR) experiments at 21...
January 31, 2017: Solid State Nuclear Magnetic Resonance
Rongni Dou, Junya Zhang, Yuancai Chen, Siyuan Feng
In order to expand the potential applications of metal-organic frameworks (MOFs), structure directing agents modified mesoporous MIL-53(Al) (MIL-53(Al)-1) was investigated to adsorb triclosan (TCS) with two different initial concentrations. MIL-53(Al)-1 with high mesoporosity and total pore volume exhibited higher adsorption capacity and 4.4 times faster adsorption of TCS at low concentration (1 mg L(-1)) than that of microporous MIL-53(Al). Also, mesoporous as well as microporous MIL-53(Al) showed significant higher adsorption capacity and two orders of magnitude greater fast uptake of TCS than two kinds of mesoporous-activated carbon...
February 18, 2017: Environmental Science and Pollution Research International
Nina H Grootendorst-van Mil, Régine P M Steegers-Theunissen, Albert Hofman, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
OBJECTIVE: Season of birth has repeatedly been found to be a risk indicator for adverse neurodevelopmental outcomes. Several explanations for this finding have been put forward but no conclusion has been reached. In the current study, we explored the role of sociodemographic and biological factors in the association between season of birth and child IQ. DESIGN: In a prenatally recruited birth cohort (born in 2002-2006), we examined the association between season of birth and non-verbal IQ at age 6 years among 6034 children...
February 17, 2017: BMJ Open
Rima Tapader, Dipro Bose, Amit Pal
YghJ, also known as SsLE (Secreted and surface associated lipoprotein) is a cell surface associated and secreted lipoprotein harbouring M60 metalloprotease domain. Though the gene is known to be conserved among both pathogenic and commensal E. coli isolates, the expression and secretion of YghJ was found to be higher among diverse Escherichia coli pathotypes. YghJ, secreted from intestinal pathogens such as enterotoxigenic E. coli (ETEC) and enteropathogenic E. coli (EPEC) has been demonstrated to possess mucinase activity and hence facilitates colonization of these enteric pathogens to intestinal epithelial cells...
February 14, 2017: Microbial Pathogenesis
Fang Huang, Qi Jinqing, Huchuan Lu, Lihe Zhang, Xiang Ruan
Object proposals are a series of candidate segments containing objects of interest, which are taken as preprocessing and widely applied in various vision tasks. However, most of existing saliency approaches only utilize the proposals to compute a location prior. In this paper, we naturally take the proposals as the bags of instances of multiple instance learning (MIL), where the instances are the superpixels contained in the proposals, and formulate saliency detection problem as a MIL task (i.e., predict the labels of instances using the classifier in the MIL framework)...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Bing Li, Chunfeng Yuan, Weihua Xiong, Weiming Hu, Houwen Peng, Xinmiao Ding, Stephen Maybank
In multi-instance learning (MIL), the relations among instances in a bag convey important contextual information in many applications. Previous studies on MIL either ignore such relations or simply model them with a fixed graph structure so that the overall performance inevitably degrades in complex environments. To address this problem, this paper proposes a novel multi-view multi-instance learning algorithm (M2IL) that combines multiple context structures in a bag into a unified framework. The novel aspects are: (i) we propose a sparse "-graph model that can generate different graphs with different parameters to represent various context relations in a bag, (ii) we propose a multi-view joint sparse representation that integrates these graphs into a unified framework for bag classification, and (iii) we propose a multi-view dictionary learning algorithm to obtain a multi-view graph dictionary that considers cues from all views simultaneously to improve the discrimination of the M2IL...
February 14, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
Mário Mil-Homens, Carlos Vale, Pedro Brito, Filipa Naughton, Teresa Drago, Joana Raimundo, Bárbara Anes, Sabine Schmidt, Miguel Caetano
Stable Pb isotopic ratios and concentrations of Al, Cu and Pb were measured in a 5m long sediment core (VC2B) retrieved at 96m water depth in the southwestern Iberian Atlantic shelf. Five phases during the last 9.5kyrs were identified, two of them (Roman Period and modern mining) marked by a decrease of (206)Pb/(207)Pb ratios reflecting additional inputs of Pb derived from mining activities. The Roman Period was also characterized by high (208)Pb/(206)Pb ratios suggesting the exploitation of the outcropping portion of the orebody intensely weathered when compared with the other formations later mined...
February 13, 2017: Science of the Total Environment
Tim A Wezendonk, Quirinus S E Warringa, Vera P Santos, Adam Chojecki, Matthijs Ruitenbeek, Garry Meima, Michiel Makkee, Freek Kapteijn, Jorge Gascon
The structure and elementary composition of various commercial Fe-based MOFs used as precursors for Fischer-Tropsch synthesis (FTS) catalysts have a large influence on the high-temperature FTS activity and selectivity of the resulting Fe on carbon composites. The selected Fe-MOF topologies (MIL-68, MIL-88A, MIL-100, MIL-101, MIL-127, and Fe-BTC) differ from each other in terms of porosity, surface area, Fe and heteroatom content, crystal density and thermal stability. They are re-engineered towards FTS catalysts by means of simple pyrolysis at 500 °C under a N2 atmosphere and afterwards characterized in terms of porosity, crystallite phase, bulk and surface Fe content, Fe nanoparticle size and oxidation state...
February 14, 2017: Faraday Discussions
Qingchang Chen, Meng Xu, Wenjing Zheng, Taoyuan Xu, Hong Deng, Jie Liu
We report here a novel and personalized strategy of selenium/ruthenium nanoparticles modified metal organic frameworks MIL-101(Fe) for delivering pooled small interfering RNAs (siRNAs) to enhance therapy efficacy by silencing multi-drug resistance (MDR) genes and interfere with microtubule (MT) dynamics in MCF-7/T (Taxol-resistance) cell. The existence of coordinatively unsaturated metal sites (CUSs) in MIL-101(Fe) can strongly interactions with the electron-rich functional groups of cysteine, which can be regarded as the linkage between selenium/ruthenium nanoparticles and MIL-101(Fe)...
February 13, 2017: ACS Applied Materials & Interfaces
Terutsugu Koya, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Shigetaka Shimodaira
Active human dendritic cells (DCs), which efficiently induce immune responses through their functions as antigen-presenting cells, exhibit direct anti-tumour killing activity in response to some pathogens and cytokines. These antigen-presenting and tumour killing abilities may provide a breakthrough in cancer immunotherapy. However, the mechanisms underlying this killer DC activity have not been fully proven, despite the establishment of interferon-α (IFN-α)-generated killer DCs (IFN-DCs). Here mature IFN-DCs (mIFN-DCs), generated from IFN-DCs primed with OK-432 (streptococcal preparation), exhibited elevated expression of CD86 and human leukocyte antigen-DR (minimum criteria for DC vaccine clinical trials) as well as antigen-presenting abilities comparable with those of mature IL-4-DCs (mIL-4-DCs)...
February 13, 2017: Scientific Reports
Huimin Yang, Honghan Fei
We present a facile and compelling method for the synthesis of metal-organic framework (MOF) thin films on TiO2-coated conductive glass substrates. This generic deposition approach is extended to five representative MOF films (e.g. UiO, MIL, IRMOF, and NU series) with high crystallinity and excellent surface coverage, achieving a MOF/TiO2 heterostructure interface. The tunable thickness and functionality of MOF films as well as the preferred orientation of MOF microcrystallites are described. After the incorporation of [Ru(bpy)3](2+) functionality via postsynthetic ligand exchange, the resultant MOF films serve as a robust and efficient catalyst for photo-oxidation of thioanisole...
February 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Vittoria Massafra, Alexandra Milona, Harmjan R Vos, Boudewijn M T Burgering, Saskia W C van Mil
Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR). FGF19 is secreted and signals to the liver, where it contributes to the homeostasis of bile acid (BA), lipid and carbohydrate metabolism. FGF19 is a promising therapeutic target for the metabolic syndrome and cholestatic diseases, but enthusiasm for its use has been tempered by FGF19-mediated induction of proliferation and hepatocellular carcinoma. To inform future rational design of FGF19-variants, we have conducted temporal quantitative proteomic and gene expression analyses to identify FGF19-targets related to metabolism and proliferation...
2017: PloS One
Zhen-Ji Guo, Jiamei Yu, Yong-Zheng Zhang, Jian Zhang, Ya Chen, Yufeng Wu, Lin-Hua Xie, Jian-Rong Li
Three new water-stable In(III)-based metal-organic frameworks, namely, [In3(TTTA)2(OH)3(H2O)]·(DMA)3 (BUT-70, DMA = N,N-dimethylacetamide), [In3(TTTA)2(CH3O)3] (BUT-70A), and [In3(TTTA)2(OH)3] (BUT-70B), with rod-shaped secondary building units (SBUs) and an new acrylate-based ligand, (2E,2'E,2″E)-3,3',3″-(2,4,6-trimethylbenzene-1,3,5-triyl)-triacrylate (TTTA(3-)) were obtained and structurally characterized. BUT-70A and -70B were generated in a single-crystal to single-crystal transformation fashion from BUT-70 through guest exchange followed by their removal...
February 6, 2017: Inorganic Chemistry
Yonghui Xu, Huaqing Min, Qingyao Wu, Hengjie Song, Bicui Ye
Multi-Instance (MI) learning has been proven to be effective for the genome-wide protein function prediction problems where each training example is associated with multiple instances. Many studies in this literature attempted to find an appropriate Multi-Instance Learning (MIL) method for genome-wide protein function prediction under a usual assumption, the underlying distribution from testing data (target domain, i.e., TD) is the same as that from training data (source domain, i.e., SD). However, this assumption may be violated in real practice...
February 6, 2017: Scientific Reports
Jesse J Balic, Christoph Garbers, Stefan Rose-John, Liang Yu, Brendan J Jenkins
Deregulated gp130-dependent STAT3 signalling by the pleiotropic cytokine interleukin (IL)-11 has been implicated in the pathogenesis of gastric cancer (GC), the third most common cancer worldwide. While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound IL-11 receptor (mIL-11R), recent evidence suggests that mIL-11R can be proteolytically cleaved to generate a soluble form (sIL-11R) which can elicit trans-signalling. Since the role of IL-11 trans-signalling in disease pathogenesis is unknown, here we have employed the IL-11-driven gp130(F/F) spontaneous model of GC to determine whether IL-11 trans-signalling promotes gastric tumourigenesis...
February 1, 2017: Cytokine
Anastasia Permyakova, Oleksandr Skrylnyk, Emilie Courbon, Maame Affram, Sujing Wang, U-Hwang Lee, Anil H Valekar, Farid Nouar, Georges Mouchaham, Thomas Devic, Guy De Weireld, Jong-San Chang, Nathalie Steunou, Marc Frère, Christian Serre
The energy storage capacities of a series of water-stable porous MOFs, based on high valence metal cations (Al3+, Fe3+, Cr3+, Ti4+, Zr4+) and polycarboxylate linkers, have been evaluated in the typical conditions of seasonal energy storage devices. It turned out that the microporous hydrophilic Al-dicarboxylate MIL-160(Al) exhibits one of the best performance. To assess the properties of this material for space heating applications and on a laboratory pilot scale with an open reactor, a novel synthetic route involving safer, greener conditions was developed...
February 3, 2017: ChemSusChem
T De Mil, M Devreese, A Maes, S De Saeger, P De Backer, S Croubels
No abstract text is available yet for this article.
February 4, 2017: Poultry Science
George Anifandis, Ourania Markandona, Konstantinos Dafopoulos, Christina Messini, Aspasia Tsezou, Marina Dimitraki, Panagiotis Georgoulias, Alexandros Daponte, Ioannis Messinis
Human MLH3 (hMLH3) gene has been suggested to play a role in the DNA mismatch repair mechanism, while it may also be associated with abnormal spermatogenesis and subsequently male infertility. The aim of the present study was to investigate possible relationships between the single nucleotide polymorphism (SNP) rs175080 in the MLH3 gene of males and the embryological results in couples undergoing intracytoplasmatic sperm injection-embryo transfer (ICSI-ET) treatments. A total of 132 men volunteered for the study and gave written informed consent...
February 2, 2017: International Journal of Molecular Sciences
Xialin Luo, Gongke Li, Yufei Hu
In this work, a novel NH2-MIL-53(Al) incorporated poly(styrene-divinylbenzene-methacrylic acid) (poly(St-DVB-MAA)) monolith was prepared via chemical fabrication. Moreover, it has been efficiently applied to the in-tube solid-phase microextraction (SPME) for online coupling with high-performance liquid chromatography (HPLC) to the direct determination of five estrogens in human urine samples. The NH2-MIL-53(Al)-polymer monolith was suitable for in-tube SPME owing to its good permeability, high extraction efficiency, chemical stability, good reproducibility and long lifetime...
April 1, 2017: Talanta
Elaheh Sedghamiz, Majid Moosavi
Three imidazolium-based linear tricationic ionic liquids, LTILs, have been simulated to study their structural and dynamical properties and to obtain a fundamental understanding of molecular basis of microscopic and macroscopic properties of their bulk liquid phase. The effects of temperature and alkyl chain length on physiochemical, transport and structural properties of these LTILs have been investigated. A non-polarizable all atom force field which is a refined version of Canongia Lopes and Paudua (CL&P) force field was adopted for the simulations...
February 2, 2017: Journal of Physical Chemistry. B
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