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Hui Yang, Tuo Li, Lu Liu, Na Li, Ming Guan, Yangyang Zhang, Zhenpeng Wang, Zhenwen Zhao
Microdialysis (MD) has been extensively used for in vivo sampling of hydrophilic analytes such as neurotransmitters and drug metabolites. In contrast, there have been few reports on sampling of lipophilic analytes by MD. Lipophilic analytes are easily adsorbed on the surfaces of the dialysis membrane and the inner wall of tubing, which leads to a very low relative recovery (RR). In this work, a strategy to develop an enhanced MD sampling of fatty acids (FAs) by using metal-organic frameworks (MOFs) as affinity agents in the perfusion fluid was investigated...
April 18, 2018: Analyst
Mina Yousefi, Adam Krzyżak, Ching Y Suen
Digital breast tomosynthesis (DBT) was developed in the field of breast cancer screening as a new tomographic technique to minimize the limitations of conventional digital mammography breast screening methods. A computer-aided detection (CAD) framework for mass detection in DBT has been developed and is described in this paper. The proposed framework operates on a set of two-dimensional (2D) slices. With plane-to-plane analysis on corresponding 2D slices from each DBT, it automatically learns complex patterns of 2D slices through a deep convolutional neural network (DCNN)...
April 12, 2018: Computers in Biology and Medicine
Xin-Ran Shi, Xue-Lei Chen, Yu-Lan Hao, Li Li, Hou-Jun Xu, Man-Man Wang
Magnetic solid-phase extraction is an effective and useful technique to preconcentrate trace analytes from food samples. In this study, a magnetic trimeric chromium octahedral metal-organic framework (Fe3 O4 -NH2 @MIL-101) was fabricated and characterized. Fe3 O4 -NH2 @MIL-101 was applied as an adsorbent of magnetic solid-phase extraction combined with high performance liquid chromatography to effectively isolate and simultaneously determine six Sudan dyes (Para Red, Sudan I-IV, and Sudan Red 7B) from tomato sauce...
April 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Wei Huang, Hongyu Sun, Huihui Shangguan, Xianyi Cao, Xinxin Xiao, Fei Shen, Kristian Mølhave, Lijie Ci, Pengchao Si, Jingdong Zhang
Three-dimensional (3D) carbon-wrapped iron sulfide interlocked graphene (Fe7S8@C-G) composites for high-performance sodium-ion storage are designed and produced through electrostatic interactions and subsequent sulfurization. The iron-based metal-organic frameworks (MOFs, MIL-88-Fe) interact with graphene oxide sheets to form 3D networks, and carbon-wrapped iron sulfide (Fe7S8@C) nanoparticles with high individual-particle conductivity are prepared following a sulfurization process, surrounded by interlocked graphene sheets to enhance the interparticle conductivity...
April 17, 2018: Nanoscale
Nicola Gargiulo, Antonio Peluso, Paolo Aprea, Luca Micoli, Angelo Ausiello, Maria Turco, Ottavio Marino, Raffaele Cioffi, Elio Jannelli, Domenico Caputo
In this work, the potentialities of the amino-functionalized, chromium-based MIL-101 metal organic framework (NH2 -MIL-101) as a high capacity, fully regenerable hydrogen chloride adsorbent have been proved by a thorough adsorption thermodynamics investigation. The chosen adsorbent showed high gaseous HCl adsorption capacities and, to the best of our knowledge, it is the first example of a totally regenerable substrate for this kind of adsorbate, as evidenced by both experimental and modeling results. This paves the way to the implementation of greener, more energetically efficient pressure / temperature swing adsorption processes to purify biogas feeds for high temperature fuel cells...
April 17, 2018: ACS Applied Materials & Interfaces
Yanzheng Cai, Yiping Wu, Tong Xuan, Xiaoyu Guo, Ying Wen, Hai-Feng Yang
Abuse of methenamine in foodstuff is harmful to the health of people. Routine methods recommended by national standard are indirect assay with complicated pretreatment of sample or less sensitivity. In this work, core-shell Au nanoparticles@inositol hexaphosphate@MIL-101(Fe) nanoparticles, designated as Au@MIL-101, are successfully synthesized by layer-by-layer assembly. Metal-organic framework (MOF, MIL-101) modified AuNPs could narrow the distance between neighboring Au@MIL-101, which increases the amount of "hot spots and contributes excellent enhancement of Raman scattering...
April 17, 2018: ACS Applied Materials & Interfaces
Hailong Wang, Quanqin Hu, Yuan Meng, Zier Jin, Zilin Fang, Qinrui Fu, Wenhua Gao, Liang Xu, Yibing Song, Fushen Lu
Reduced graphite oxide (rGO) was incorporated into a metal organic framework (MOF) MIL-101(Cr) for the modification of carbon paste electrode. Taking advantages of the large surface area of MOF and the electrical conductivity of rGO, the resulted electrodes exhibited high sensitivity and reliability in the simultaneous electrochemical identification and quantification of catechol (CC) and hydroquinone (HQ). Specifically, in the mixture solution of catechol and hydroquinone (constant concentration of an analyte), the linear response ranges for catechol and hydroquinone were 10-1400 μM and 4-1000 μM, and detection limits were 4 μM and 0...
February 19, 2018: Journal of Hazardous Materials
Yuqian Jia, Yanfang Zhao, Mei Zhao, Zhenhua Wang, Xiangfeng Chen, Minglin Wang
A core-shell discoid shaped indium (III) sulfide@metal-organic framework (MIL-125(Ti)) nanocomposite was synthesized by a solvothermal method and explored as an adsorbent material for dispersive solid-phase extraction (d-SPE). The as-synthesized sorbent was characterized by scanning electron microscopy, energy-dispersive spectroscopy, transmission electron microscopy, powder X-ray diffraction, N2 adsorption-desorption analysis, and Fourier transform infrared spectroscopy. The extraction performance was evaluated by the d-SPE of 16 nitro-polycyclic aromatic hydrocarbons (NPAHs) from water samples...
April 5, 2018: Journal of Chromatography. A
Wenshuang Wu, Feng Liu, Anping Su, Yanping Gong, Wanjun Zhao, Yang Liu, Haoyu Ye, Jingqiang Zhu
Millepachine (MIL) is a bioactive natural product that shows great potential for cancer treatment. Previous studies showed that MIL was a novel cancer drug candidate with a special structure. To provide reference for the research and development of MIL, we further investigated the mechanism of MIL inducing G2/M arrest and found MIL disrupted spindle assembly in tumor cells. In this study, we investigated the disrupting spindle assembly effects of MIL with a focus on its potential mechanism of action. First, we indicated that MIL did not inhibit microtubule polymerization from the results of in-vivo microtubule nucleation assay and microtubule polymerization in-vitro assay but delayed this process by inhibiting the production of ATP in tumor cells...
June 2018: Anti-cancer Drugs
Jordi Espín, Luis Garzón-Tovar, Gerard Boix, Inhar Imaz, Daniel Maspoch
Here, we report the covalent post-synthetic modification (CPSM) of MOFs using the photothermal effect. Specifically, we subjected mixtures of a photothermally active MOF and another reagent to irradiation with a UV-Vis lamp. This caused the MOF to heat up, which in turn caused the other reagent to melt and subsequently react with the functional groups on the walls of the MOF pores. We have exploited this dual function of MOFs as both heater and host for CPSMs to achieve rapid formation of amides from the reaction of representative MOFs (UiO-66-NH2 or MIL-101-NH2-(Al)) with anhydrides under solvent-free conditions...
April 9, 2018: Chemical Communications: Chem Comm
Giulia P M Bignami, Zachary H Davis, Daniel M Dawson, Samuel A Morris, Samantha E Russell, David McKay, Richard E Parke, Dinu Iuga, Russell E Morris, Sharon E Ashbrook
17 O solid-state NMR spectroscopy is employed to investigate the cation disorder in metal-organic frameworks containing two different types of metal cations. Although NMR offers exquisite sensitivity to the local, atomic-scale structure, making it an ideal tool for the characterisation of disordered materials, the low natural abundance of17 O (0.037%) necessitates expensive isotopic enrichment to acquire spectra on a reasonable timescale. Using dry gel conversion and a novel steaming method we show that cost-effective and atom-efficient enrichment of MOFs is possible, and that high-resolution17 O NMR spectra are sensitive both to the structural forms of the MOF and the presence of guest molecules...
January 28, 2018: Chemical Science
Sara Rojas, Isabel Colinet, Denise Cunha, Tania Hidalgo, Fabrice Salles, Christian Serre, Nathalie Guillou, Patricia Horcajada
Although metal-organic frameworks (MOFs) have widely demonstrated their convenient performances as drug-delivery systems, there is still work to do to fully understand the drug incorporation/delivery processes from these materials. In this work, a combined experimental and computational investigation of the main structural and physicochemical parameters driving drug adsorption/desorption kinetics was carried out. Two model drugs (aspirin and ibuprofen) and three water-stable, biocompatible MOFs (MIL-100(Fe), UiO-66(Zr), and MIL-127(Fe)) have been selected to obtain a variety of drug-matrix couples with different structural and physicochemical characteristics...
March 31, 2018: ACS Omega
Nina H Grootendorst-van Mil, Anna R M Huiskens, Sieds Dieleman, Tom K Birkenhäger
The clinical management of patients with treatment-resistant psychotic disorders is still challenging despite years of extensive research. If first-line antipsychotic treatment proves ineffective, clozapine is considered golden standard. Herein, we report on a patient with schizoaffective disorder that initially showed no response to treatment with clozapine and ECT and therefore reached a therapeutic dead end. After an unintentional exposure to supratherapeutic clozapine levels, related to a pneumonia, a significant and persistent reduction of psychotic symptoms occurred...
2018: Case Reports in Psychiatry
Atefe Nasrollahpour, Seyyed Ershad Moradi
A vortex-assisted magnetic dispersive solid phase microextraction coupled with high-performance liquid chromatography has been developed for the extraction and determination of triazine herbicides by using magnetic metal organic frameworks [Fe₃O₄@MIL-100(Fe)] in environmental water and vegetable samples. The Fe₃O₄@MIL-100(Fe) composite has been characterized by using X-ray diffraction spectroscopy, tunneling electron microscopy, thermogravimetric measurement, and Brunauer-Emmett-Teller analysis. The method is based on the sorption of triazine herbicides on Fe₃O₄@MIL-100(Fe) because of the complex formation between iron oxide nanoparticles and triazine herbicides beside π-π interactions between organic parts of Fe₃O₄@MIL-100(Fe) and triazine herbicides...
April 4, 2018: Journal of AOAC International
Juntao Tang, Jianlong Wang
In this paper, a novel Fenton-like catalyst, metal organic framework MIL-100(Fe) with FeII/FeIII mixed-valence coordinatively unsaturated iron center (CUS-MIL-100(Fe)), was synthesized, characterized and used for the degradation of sulfamethazine (SMT). The catalytic performance of CUS-MIL-100(Fe) was investigated on the basis of various parameters, including initial pH, H2O2 concentration, catalyst dosage and initial SMT concentration. The results showed that CUS-MIL-100(Fe) could effectively degrade SMT, with almost 100% removal efficiency within 180 min (52...
April 4, 2018: Environmental Science & Technology
Kevin Dedecker, Renjith S Pillai, Farid Nouar, Joao Pires, Nathalie Steunou, Eddy Dumas, Guillaume Maurin, Christian Serre, Moisés L Pinto
The removal of low concentrations of acetic acid from indoor air at museums poses serious preservation problems that the current adsorbents cannot easily address owing to their poor affinity for acetic acid and/or their low adsorption selectivity versus water. In this context, a series of topical water stable Metal Organic-Frameworks (MOFs) with different pore sizes, topologies, hydrophobic character and functional groups was explored through a joint experimental-computational exploration. We demonstrate how a subtle combination of sufficient hydrophobicity and optimized host-guest interactions allows to overcome the challenge of capturing traces of this very polar volatile organic compound in the presence of humidity...
April 3, 2018: ACS Applied Materials & Interfaces
José María Moreno, Alexandra Velty, José A Vidal-Moya, Urbano Díaz, Avelino Corma
Novel aluminium MOF-type materials structured by 1D subdomains, such as organic-inorganic nanoribbons, were synthesized by modifying the conditions of solvothermal synthesis and the nature of the solvents in the presence of aryl monocarboxylate linkers with long alkyl chains, which acted as growth-modulating agents. Specifically, three different families of materials were prepared with various morphological characteristics: (i) isoreticular MIL-53(Al)-type materials, (ii) mesoscopic metalorganic structures and (iii) lamellar aluminium MOFs...
April 3, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Li Yao, Haitao Liu, Xie Wang, Wenzhi Xu, Yongqun Zhu, Hong Wang, Liangyu Pang, Chaowen Lin
A novel ultrasound-assisted surfactant-enhanced emulsification microextraction (UASEME) using a magnetic ionic liquid (MIL) coupled with micro-solid phase extraction was developed for the preconcentration of cadmium and lead in edible vegetable oils prior to analysis by graphite furnace atomic absorption spectrometry. MIL [C4 mim] [FeCl4 ] was used as the extractant, non-ionic surfactant Triton X-100 as the emulsifier and Fe3 O4 nanoparticles as the sorbent, while ultrasound was applied to assist the dispersion of the extractant and accelerate the mass transfer process...
August 1, 2018: Food Chemistry
Martine Uittenbogaard, Christine A Brantner, ZiShui Fang, Lee-Jun C Wong, Andrea Gropman, Anne Chiaramello
In this study, we report a novel perpective of metabolic consequences for the m.8993T>G variant using fibroblasts from a proband with clinical symptoms compatible with Maternally Inherited Leigh Syndrome (MILS). Definitive diagnosis was corroborated by mitochondrial DNA testing for the pathogenic variant m.8993T>G in MT-ATP6 subunit by Sanger sequencing. The long-range PCR followed by massively parallel sequencing method detected the near homoplasmic m.8993T>G variant at 83% in the proband's fibroblasts and at 0...
March 27, 2018: Molecular Genetics and Metabolism
Myrthe Suzanne Gilbert, Noortje Ijssennagger, Arie K Kies, Saskia W C van Mil
The amount of dietary protein is associated with intestinal disease in different vertebrate species. In humans, this is exemplified by the association between high protein intake and fermentation metabolite concentrations in patients with inflammatory bowel disease. In production animals, dietary protein intake is associated with post-weaning diarrhea in piglets and with the occurrence of wet litter in poultry. The underlying mechanisms by which dietary protein contributes to intestinal problems remain largely unknown...
March 29, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
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