Salma Younes, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Hanin I Daas, Duaa W Al-Sadeq, Nadin Younes, Farah M Shurrab, Parveen B Nizamuddin, Fathima Humaira, Nader Al-Dewik, Hadi M Yassine, Laith J Abu-Raddad, Ahmed Ismail, Gheyath K Nasrallah
BACKGROUND: Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime-boost vaccination using BNT162b2 or mRNA-1273. METHODS: We matched vaccinated naïve (VN) individuals (n = 673) with partial vaccination (n = 64), primary vaccination (n = 590), and primary series plus mRNA vaccine heterologous booster (n = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS-CoV-2 infection (n = 206)...
May 2024: Influenza and Other Respiratory Viruses