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https://www.readbyqxmd.com/read/29788180/rotavirus-vaccination-is-associated-with-reduced-seizure-hospitalization-risk-among-commercially-insured-u-s-children
#1
Rachel M Burke, Jacqueline E Tate, Rebecca Moritz Dahl, Negar Aliabadi, Umesh D Parashar
Rotavirus commonly causes diarrhea but can also cause seizures. Analysis of insurance claims for 1,773,295 US children with 2950 recorded seizures found that, compared to rotavirus-unvaccinated children, seizure hospitalization risk was reduced by 24% (95% confidence interval [CI], 13% - 33%) and 14% (95%CI, 0% - 26%) among fully and partially rotavirus-vaccinated children, respectively.
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29786520/impact-of-piglet-oral-vaccination-against-tuberculosis-in-endemic-free-ranging-wild-boar-populations
#2
Iratxe Díez-Delgado, Iker A Sevilla, Beatriz Romero, Eleanor Tanner, Jose A Barasona, Andrew R White, Peter W W Lurz, Mike Boots, José de la Fuente, Lucas Dominguez, Joaquin Vicente, Joseba M Garrido, Ramón A Juste, Alicia Aranaz, Christian Gortazar
The Eurasian wild boar (Sus scrofa) is the main wild reservoir of the Mycobacterium tuberculosis complex in Mediterranean woodlands and a key risk factor for cattle tuberculosis (TB) breakdowns. Wild boar vaccination therefore has the potential to be a valuable tool for TB control. We tested two orally delivered vaccines, heat-inactivated Mycobacterium bovis (IV) and BCG, in four sites (two per vaccine type: one Managed and one Natural or unmanaged) during four years. TB was also monitored in 15 unvaccinated sites (spatial control), as well as in all sites from one year prior to intervention (temporal control)...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29783157/vaccines-and-the-association-with-relapses-in-patients-with-neuromyelitis-optica-spectrum-disorder
#3
Maureen A Mealy, Lawrence J Cook, Florence Pache, Diego L Velez, Nadja Borisow, Daniel Becker, Jorge A Jimenez Arango, Friedemann Paul, Michael Levy
BACKGROUND: It is unknown if vaccines cause non-specific immune activation in patients with neuromyelitis optica spectrum disorder and no consensus on the use of vaccines exists for this population. We investigated the temporal association of vaccinations with relapses in patients with neuromyelitis optica spectrum disorder. METHODS: This is a multi-center retrospective analysis of patients with neuromyelitis optica spectrum disorder for whom immunization history and clinical records from disease onset were available...
May 7, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29780771/proposal-for-cervical-cancer-screening-in-the-era-of-hpv-vaccination
#4
REVIEW
Yung-Taek Ouh, Jae Kwan Lee
Eradication of cervical cancer involves the expansion of human papillomavirus (HPV) vaccine coverage and the development of efficient screening guidelines that take vaccination into account. In Korea, the HPV National Immunization Program was launched in 2016 and is expected to shift the prevalence of HPV genotypes in the country, among other effects. The experiences of another countries that implement national immunization programs should be applied to Korea. If HPV vaccines spread nationwide with broader coverage, after a few decades, cervical intraepithelial lesions or invasive cancer should become a rare disease, leading to a predictable decrease in the positive predictive value of cervical screening cytology...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29779923/a-viral-vectored-rsv-vaccine-induces-long-lived-humoral-immunity-in-cotton-rats
#5
Jessica L Grieves, Zhiwei Yin, Adolfo Garcia-Sastre, Ignacio Mena, Mark E Peeples, Heidi P Risman, Hannah Federman, Marvin J Sandoval, Russell K Durbin, Joan E Durbin
Human respiratory syncytial virus (RSV) is the leading cause of lower airway disease in infants worldwide and repeatedly infects immunocompetent individuals throughout life. Severe lower airway RSV infection during infancy can be life-threatening, but is also associated with important sequelae including development of asthma and recurrent wheezing in later childhood. The basis for the inadequate, short-lived adaptive immune response to RSV infection is poorly understood, but it is widely recognized that RSV actively antagonizes Type I interferon (IFN) production...
May 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29778520/effectiveness-of-hpv-vaccination-against-high-grade-cervical-lesions-in-japan
#6
Ryo Konno, Hiroshi Konishi, Catherine Sauvaget, Yasuo Ohashi, Tadao Kakizoe
The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69% lower risk of HSIL+ as compared to the unvaccinated women; the crude relative risk estimate was 0.31 (95% CI: 0.11-0.83; p-value = 0.013) by normal approximation and 0.31 (95% CI: 0.08-0...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29776921/determining-the-pneumococcal-conjugate-vaccine-coverage-required-for-indirect-protection-against-vaccine-type-pneumococcal-carriage-in-low-and-middle-income-countries-a-protocol-for-a-prospective-observational-study
#7
Jocelyn Chan, Cattram D Nguyen, Jana Y R Lai, Eileen M Dunne, Ross Andrews, Christopher C Blyth, Siddhartha Datta, Kim Fox, Rebecca Ford, Jason Hinds, Sophie La Vincente, Deborah Lehmann, Ruth Lim, Tuya Mungun, Paul N Newton, Rattanaphone Phetsouvanh, Willam S Pomat, Anonh Xeuatvongsa, Claire von Mollendorf, David A B Dance, Catherine Satzke, Kim Muholland, Fiona M Russell
INTRODUCTION: Pneumococcal conjugate vaccines (PCVs) prevent disease through both direct protection of vaccinated individuals and indirect protection of unvaccinated individuals by reducing nasopharyngeal (NP) carriage and transmission of vaccine-type (VT) pneumococci. While the indirect effects of PCV vaccination are well described, the PCV coverage required to achieve the indirect effects is unknown. We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children using hospital-based NP pneumococcal carriage surveillance at three sites in Asia and the Pacific...
May 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/29773279/-non-tuberculous-mycobacterial-cervical-adenitis-in-children-2-cases
#8
N Sigg, S Bailleul, J-M Turmel, G Legrand, S Kettani, L Martin
BACKGROUND: Cervical lymphadenitis is the most common manifestation of infection with nontuberculous mycobacteria (NTM) in immunocompetent children. Nevertheless, it is poorly known by dermatologists. Its incidence, which is currently increasing since the cessation of BCG vaccination in 2007, raises several issues regarding its pathophysiology, diagnosis and management. PATIENTS AND METHODS: We report two cases of NTM adenitis: one in a 2-year-old girl vaccinated with BCG and one in an unvaccinated 22-month-old boy, in whom a misleading presentation led to delayed diagnosis...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29770135/mucosal-immunity-and-protective-efficacy-of-intranasal-inactivated-influenza-vaccine-is-improved-by-chitosan-nanoparticle-delivery-in-pigs
#9
Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J Renukaradhya
Annually, swine influenza A virus (SwIAV) causes severe economic loss to swine industry. Currently used inactivated SwIAV vaccines administered by intramuscular injection provide homologous protection, but limited heterologous protection against constantly evolving field viruses, attributable to the induction of inadequate levels of mucosal IgA and cellular immune responses in the respiratory tract. A novel vaccine delivery platform using mucoadhesive chitosan nanoparticles (CNPs) administered through intranasal (IN) route has the potential to elicit strong mucosal and systemic immune responses in pigs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29769253/effectiveness-of-23-valent-pneumococcal-polysaccharide-vaccine-on-elderly-long-term-cancer-survivors-a-population-based-propensity-score-matched-cohort-study
#10
Wen-Yen Chiou, Moon-Sing Lee, Shih-Kai Hung, Hon-Yi Lin, Yuan-Chen Lo, Feng-Chun Hsu, Shiang-Jiun Tsai, Chung-Yi Li
OBJECTIVE: The Advisory Committee on Immunization Practices in 2012 recommended the 23-valent pneumococcal polysaccharide vaccine (PPSV23) for adults with high risk of pneumonia. However, its effectiveness in cancer survivors has not been investigated. Our aim was to investigate the effectiveness of PPSV23 in these patients. DESIGN: Population-based matched cohort study. SETTING: Claim data were obtained from 1 million people registered with the National Health Insurance Research Database in 1996, and followed to 2010...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29766840/rubella-infection-in-pregnancy-and-congenital-rubella-in-united-kingdom-2003-to-2016
#11
Antoaneta Bukasa, Helen Campbell, Kevin Brown, Helen Bedford, Mary Ramsay, Gayatri Amirthalingam, Pat Tookey
Rubella vaccination has been included in the United Kingdom's (UK) routine childhood schedule for nearly 30 years. The UK achieved World Health Organization (WHO) elimination status in 2016 and acute rubella infections are rare. In the period 2003-16, 31 rubella infections in pregnancy (0.23 per 100,000 pregnancies) were identified through routine surveillance, of which 26 were in women who were born abroad. Five of the 31 rubella infections led to congenital rubella syndrome in the infant and three had confirmed congenital rubella infection without congenital rubella syndrome...
May 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29765009/parent-provider-communication-of-hpv-vaccine-hesitancy
#12
Laura A Shay, Austin S Baldwin, Andrea C Betts, Emily G Marks, Robin T Higashi, Richard L Street, Donna Persaud, Jasmin A Tiro
: media-1vid110.1542/5754332185001PEDS-VA_2017-2312 Video Abstract OBJECTIVES: To prevent human papillomavirus (HPV)-related cancers, providers must effectively communicate with HPV vaccine-hesitant parents. Here, we developed a typology characterizing parent-provider communication around HPV vaccine hesitancy. METHODS: We audio-recorded 43 visits with unvaccinated adolescents at 6 pediatric clinics in Dallas, Texas in which parents were undecided about HPV vaccination. We qualitatively coded how parents verbally expressed hesitancy (assertive response, asking a question, or expressing concern) and whether providers responded with acquiescence (agree to defer vaccination) and/or persistence (continue discussion)...
May 15, 2018: Pediatrics
https://www.readbyqxmd.com/read/29764963/reducing-missed-opportunities-for-influenza-vaccination-in-patients-with-rheumatoid-arthritis-evaluation-of-a-multisystem-intervention
#13
Rachel Broderick, Iazsmin Ventura, Sunoz Soroosh, Lourdes Franco, Jon T Giles
OBJECTIVE: To assess a multimodal intervention for reducing missed opportunities for outpatient influenza vaccination in individuals with rheumatoid arthritis (RA). METHODS: Patients with RA were enrolled from a single center and each rheumatology outpatient visit was tracked for missed opportunities for influenza vaccination, defined as a visit in which an unvaccinated patient without contraindications remained unvaccinated or lacked documentation of vaccine recommendation in the electronic medical record (EMR)...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29761340/reduction-of-direct-health-costs-associated-with-pertussis-vaccination-with-acellular-vaccines-in-children-aged-0-9-years-with-pertussis-in-catalonia-spain
#14
Pedro Plans-Rubió, Encarna Navas, Pere Godoy, Gloria Carmona, Angela Domínguez, Mireia Jané, Carmen Muñoz-Almagro, Pedro Brotons
OBJECTIVES: The aim of this study was to assess direct health costs in children with pertussis aged 0-9 years who were vaccinated, partially vaccinated, and unvaccinated during childhood, and to assess the association between pertussis costs and pertussis vaccination in Catalonia (Spain) in 2012-2013. METHODS: Direct healthcare costs included pertussis treatment, pertussis detection, and preventive chemotherapy of contacts. Pertussis patients were considered vaccinated when they had received 4-5 doses, and unvaccinated or partially vaccinated when they had received 0-3 doses of vaccine...
May 14, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29748029/-knowledge-attitudes-and-practices-about-influenza-vaccination-among-pregnant-women-and-healthcare-providers-serving-pregnant-women-in-managua-nicaragua
#15
Carmen S Arriola, Nancy Vasconez, Joseph Bresee, Alba María Ropero
BACKGROUND: Nicaragua implemented an influenza vaccination program for pregnant women with high-risk obstetric conditions in 2007. In 2014, the recommendation of influenza vaccination expanded to include all pregnant women. Given the expansion in the recommendation of vaccination, we evaluated knowledge, attitudes and practices of pregnant women and their healthcare providers towards influenza vaccination and its recommendation. METHODS: We conducted surveys among pregnant women and their healthcare providers from June to August 2016 at two hospitals and 140 health facilities in Managua...
May 7, 2018: Vaccine
https://www.readbyqxmd.com/read/29743199/evaluation-of-dried-blood-spots-and-oral-fluids-as-alternatives-to-serum-for-human-papillomavirus-antibody-surveillance
#16
Karly S Louie, Jama Dalel, Caroline Reuter, Sara L Bissett, Michelle Kleeman, Lesley Ashdown-Barr, Rawinder Banwait, Anna Godi, Peter Sasieni, Simon Beddows
Human papillomavirus (HPV) vaccination elicits high-titer genotype-specific antibody responses that are associated with a reduced risk of cervical disease caused by vaccine-incorporated genotypes. Our objective was to evaluate dried blood spots (DBSs) and oral mucosal transudate (OMT) as alternative samples to serum to confirm HPV vaccine antibody status. A study was carried out to evaluate the feasibility of detecting HPV16 and HPV18 antibodies in OMT, DBSs, and sera among women who self-reported being unvaccinated or fully vaccinated with the HPV vaccine...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29742283/vaccination-practices-in-dialysis-patients-a-narrative-review
#17
REVIEW
Georges Kosmadakis, Julie Albaret, Enrique Da Costa Correia, Frederic Somda, Didier Aguilera
In a period of turmoil concerning vaccination practices, there is a serious conflict between scientifically reasonable, evidence-based guidelines and the far-fetched rumors or misconceptions concerning the vaccination practices in the general population. When a significant portion of the medical and paramedical personnel may be deliberately unvaccinated against common biological agents, achieving effective vaccination rates in the dialysis population may be complicated. Vaccination rates are unacceptably low in dialysis patients and seroconversion rates are even lower; further, serological follow-up is generally poor...
May 9, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29742150/efficacy-of-parenteral-vaccination-against-tuberculosis-with-heat-inactivated-mycobacterium-bovis-in-experimentally-challenged-goats
#18
Claudia Arrieta-Villegas, Tania Perálvarez, Enric Vidal, Zoë Puighibet, Xavier Moll, Albert Canturri, Iker A Sevilla, Yvonne Espada, Ramón A Juste, Mariano Domingo, Bernat Pérez de Val
Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. The main aim of this study was to evaluate the efficacy of parenteral vaccination of goats with a heat-inactivated Mycobacterium bovis (HIMB) vaccine, and compare it to M. bovis Bacille Calmette-Guérin (BCG) vaccine. Twenty-four goat kids were divided in 3 groups as following: HIMB vaccinated group (n = 8), BCG vaccinated group (n = 8) and unvaccinated group (n = 8)...
2018: PloS One
https://www.readbyqxmd.com/read/29740819/prophylactic-vaccination-against-human-papillomaviruses-to-prevent-cervical-cancer-and-its-precursors
#19
REVIEW
Marc Arbyn, Lan Xu, Cindy Simoens, Pierre Pl Martin-Hirsch
BACKGROUND: Persistent infection with high-risk human papillomaviruses (hrHPV) types is causally linked with the development of cervical precancer and cancer. HPV types 16 and 18 cause approximately 70% of cervical cancers worldwide. OBJECTIVES: To evaluate the harms and protection of prophylactic human papillomaviruses (HPV) vaccines against cervical precancer and HPV16/18 infection in adolescent girls and women. SEARCH METHODS: We searched MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase (June 2017) for reports on effects from trials...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29733767/prevalence-of-chlamydia-pecorum-in-juvenile-koalas-phascolarctos-cinereus-and-evidence-for-protection-from-infection-via-maternal-immunization
#20
Isabelle Russell, Peter Timms, Jon Hanger, Jo Loader, Amber Gillett, Courtney Waugh
Chlamydia pecorum in koalas ( Phascolarctos cinereus) is considered a sexually transmitted infection. Analysis of samples from koala joeys (<1 yr) suggested that mother-to-young direct transmission was also occurring. Further, evidence suggested that joeys from vaccinated mothers were less likely to contract infections than joeys with unvaccinated mothers.
May 7, 2018: Journal of Wildlife Diseases
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