Lei Chen, Chong Zhang, Ruidong Xue, Mo Liu, Jian Bai, Jinxia Bao, Yin Wang, Nanhai Jiang, Zhixuan Li, Wenwen Wang, Ruiru Wang, Bo Zheng, Airong Yang, Ji Hu, Ke Liu, Siyun Shen, Yangqianwen Zhang, Mixue Bai, Yan Wang, Yanjing Zhu, Shuai Yang, Qiang Gao, Jin Gu, Dong Gao, Xin Wei Wang, Hidewaki Nakagawa, Ning Zhang, Lin Wu, Steven G Rozen, Fan Bai, Hongyang Wang
Over half of hepatocellular carcinoma (HCC) cases diagnosed worldwide are in China1-3 . However, whole-genome analysis of hepatitis B virus (HBV)-associated HCC in Chinese individuals is limited4-8 , with current analyses of HCC mainly from non-HBV-enriched populations9,10 . Here we initiated the Chinese Liver Cancer Atlas (CLCA) project and performed deep whole-genome sequencing (average depth, 120×) of 494 HCC tumours. We identified 6 coding and 28 non-coding previously undescribed driver candidates...
February 14, 2024: Nature