keyword
MENU ▼
Read by QxMD icon Read
search

EBV and multiple sclerosis

keyword
https://www.readbyqxmd.com/read/29759135/the-levels-of-soluble-forms-of-cd21-and-cd83-in-multiple-sclerosis
#1
Sajad Karampoor, Hamid Zahednasab, Masoud Etemadifar, Hossein Keyvani
Multiple Sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS) in which immune system plays a crucial role in progression of the disease. An enormous amount of research has been shown that immune mediators such as cytokines and chemokines are the culprits of MS propagation suggesting that modulation of such molecules may pave the path to hinder the disease development. It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29735578/lifestyle-and-environmental-factors-in-multiple-sclerosis
#2
Lars Alfredsson, Tomas Olsson
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS), because genetic predisposition only explains a fraction of the risk increase. There is strong evidence for associations of Epstein-Barr virus (EBV) infection, smoking, sun exposure/vitamin D, and adolescent obesity to risk of MS. There is also circumstantial evidence on organic solvents and shift work, all associate with greater risk, although certain factors like nicotine, alcohol, and a high coffee consumption associate with a reduced risk...
May 7, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29587799/hla-alleles-modulate-ebv-viral-load-in-multiple-sclerosis
#3
Simone Agostini, Roberta Mancuso, Franca R Guerini, Sandra D'Alfonso, Cristina Agliardi, Ambra Hernis, Milena Zanzottera, Nadia Barizzone, Maurizio A Leone, Domenico Caputo, Marco Rovaris, Mario Clerici
BACKGROUND: The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular,  are associated with disease susceptibility, whereas Epstein Barr Virus (EBV) infection has long been suspected to play a role in disease pathogenesis. The aim of the present study is to evaluate correlations between HLA alleles and EBV infection in MS. METHODS: HLA alleles, EBV viral load (VL) and serum anti-EBV antibody titers were evaluated in EBV-seropositive MS patients (N = 117) and age- and sex-matched healthy controls (HC; N = 89)...
March 27, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29569515/prevalence-of-salivary-human-herpesviruses-in-pediatric-multiple-sclerosis-cases-and-controls
#4
Emily C Leibovitch, Cheng-Te Major Lin, Bridgette J Billioux, Jennifer Graves, Emmanuelle Waubant, Steven Jacobson
BACKGROUND: Multiple sclerosis (MS) is a multifactorial disease of unknown origin. The current paradigm is that disease develops in genetically susceptible individuals, influenced by environmental factors. Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) have particularly strong associations with the disease. Both viruses are typically acquired during childhood, decades before MS presents. However, in patients with pediatric MS, the temporal window between viral acquisition and disease onset is shortened, which may provide insights into the association of herpesviruses with MS...
March 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29528545/low-cytomegalovirus-seroprevalence-in-early-multiple-sclerosis-a-case-for-the-hygiene-hypothesis
#5
E Alari-Pahissa, A Moreira, A Zabalza, R Alvarez-Lafuente, E Munteis, A Vera, R Arroyo, J C Alvarez-Cermeño, L M Villar, M López-Botet, J E Martínez-Rodríguez
BACKGROUND AND PURPOSE: Cytomegalovirus (CMV) infection has recently been associated with a lower multiple sclerosis (MS) susceptibility, although it remains controversial whether it has a protective role or is merely an epiphenomenon related to westernization and early-life viral infections. We aimed to evaluate whether CMV serostatus may differ in patients with early MS as compared with patients with non-early MS, analyzing the putative association of this virus with MS clinical course and humoral immune responses against other herpesviruses...
March 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29519720/mycobacterium-avium-subspecies-paratuberculosis-and-myelin-basic-protein-specific-epitopes-are-highly-recognized-by-sera-from-patients-with-neuromyelitis-optica-spectrum-disorder
#6
Marco Bo, Magdalena Niegowska, Giannina Arru, Elia Sechi, Sara Mariotto, Chiara Mancinelli, Alessia Farinazzo, Daniela Alberti, Alberto Gajofatto, Sergio Ferrari, Ruggero Capra, Salvatore Monaco, GianPietro Sechi, Leonardo A Sechi
Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98 , IRF5424-434 ) in multiple sclerosis (MS), we investigated whether seroreactivity to these antigens display a NMOSD-specific pattern. The sera of 34 NMOSD patients showed elevated levels of antibodies against MAP and MBP compared to healthy controls (44% vs...
May 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29431301/seroepidemiological-study-of-epstein-barr-virus-in-different-population-groups-in-croatia
#7
Nataša Beader, Branko Kolarić, Domagoj Slačanac, Irena Tabain, Tatjana Vilibić-Čavlek
BACKGROUND: The Epstein-Barr virus (EBV) is one of the most common viruses found in humans, causing lifelong infection in up to 95% of the world population. OBJECTIVES: To analyze the seroprevalence of EBV infection in different population groups in Croatia. METHODS: During a 2 year period (2015-2016), a total of 2022 consecutive serum samples collected from Croatian residents were tested for the presence of EBV-specific viral capsid antigen (VCA) immunoglobulin M (IgM) and IgG antibodies using an enzyme-linked immunoassay...
February 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29394264/epstein-barr-virus-is-present-in-the-brain-of-most-cases-of-multiple-sclerosis-and-may-engage-more-than-just-b-cells
#8
Asma Hassani, John R Corboy, Suhail Al-Salam, Gulfaraz Khan
Multiple sclerosis (MS) is a chronic neuroinflammatory condition of the central nervous system (CNS). It is a major cause of neurological disability in young adults, particularly women. What triggers the destruction of myelin sheaths covering nerve fibres is unknown. Both genetic and infectious agents have been implicated. Of the infectious agents, Epstein-Barr virus (EBV), a common herpesvirus, has the strongest epidemiological and serological evidence. However, the presence of EBV in the CNS and demonstration of the underlying mechanism(s) linking EBV to the pathogenesis of MS remain to be elucidated...
2018: PloS One
https://www.readbyqxmd.com/read/29393768/the-contribution-of-secondhand-tobacco-smoke-exposure-to-pediatric-multiple-sclerosis-risk
#9
Amy M Lavery, Bradley N Collins, Amy T Waldman, Chantelle N Hart, Amit Bar-Or, Ruth Ann Marrie, Douglas Arnold, Julia O'Mahony, Brenda Banwell
BACKGROUND: Pediatric acquired demyelinating syndromes (ADSs) are monophasic (mono-ADS) in 70% of cases and represent the first attack of multiple sclerosis (MS) in 30%. Secondhand tobacco smoke (SHS) exposure has been implicated as a risk factor for adult-onset MS. Little is known about whether SHS presents an additive risk beyond genetic factors and other environmental exposures associated with pediatric MS. METHODS: This study examined SHS exposure in 216 children with mono-ADS and 81 children with MS...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29338732/transcriptional-profile-and-epstein-barr-virus-infection-status-of-laser-cut-immune-infiltrates-from-the-brain-of-patients-with-progressive-multiple-sclerosis
#10
Caterina Veroni, Barbara Serafini, Barbara Rosicarelli, Corrado Fagnani, Francesca Aloisi
BACKGROUND: It is debated whether multiple sclerosis (MS) might result from an immunopathological response toward an active Epstein-Barr virus (EBV) infection brought into the central nervous system (CNS) by immigrating B cells. Based on this model, a relationship should exist between the local immune milieu and EBV infection status in the MS brain. To test this hypothesis, we analyzed expression of viral and cellular genes in brain-infiltrating immune cells. METHODS: Twenty-three postmortem snap-frozen brain tissue blocks from 11 patients with progressive MS were selected based on good RNA quality and prominent immune cell infiltration...
January 16, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29127522/common-genetic-variation-within-mir-146a-predicts-disease-onset-and-relapse-in-multiple-sclerosis
#11
Yuan Zhou, Ming Chen, Steve Simpson, Robyn M Lucas, Jac C Charlesworth, Nicholas Blackburn, Ingrid van der Mei, Anne-Louise Ponsonby, Bruce V Taylor
Despite extensive studies focusing on the changes in expression of microRNAs (miRNAs) in multiple sclerosis (MS) compared to healthy controls, few studies have evaluated the association of genetic variants of miRNAs with MS clinical course. We investigated whether a functional polymorphism in the MS associated miR-146a gene predicted clinical course (hazard of conversion to MS and of relapse, and annualized change in disability), using a longitudinal cohort study of persons with a first demyelinating event followed up to their 5-year review...
February 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29120577/epstein-barr-virus-infection-in-multiple-sclerosis-patients
#12
Awatef M Awwad, Nesrine F Hanafi, Ghada A Achmawi, Amira M Naguib
Multiple sclerosis (MS) is the most common inflammatory autoimmune CNS disease, with unknown etiology. We aimed to determine the coexistence of MS with antibodies to Epstein-Barr virus and its gene sequences (EBNA1 and BHRF1). The study included 60 MS patients and 60 control subjects. Serum samples were processed by ELISA for detection of EBV antibodies, and latent EBV genes were determined by Real Time PCR in blood samples. While 18 (30%) MS cases had anti- EBV IgM antibodies, all controls were free. For IgG, no difference was noted (cases 96...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119120/computer-aided-design-of-an-epitope-based-vaccine-against-epstein-barr-virus
#13
Julio Alonso-Padilla, Esther M Lafuente, Pedro A Reche
Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. Currently, there are no effective drugs or vaccines to treat or prevent EBV infection. Herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemble from experimentally defined T and B cell epitopes...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29098417/low-intrathecal-antibody-production-despite-high-seroprevalence-of-epstein-barr-virus-in-multiple-sclerosis-a-review-of-the-literature
#14
REVIEW
Klemens Ruprecht, Brigitte Wildemann, Sven Jarius
BACKGROUND: Patients with multiple sclerosis (MS) frequently have an intrathecal production of antibodies to different common viruses, which can be detected by elevated antiviral antibody indices (AIs). There is a strong and consistent association of MS and Epstein-Barr virus (EBV) infection. OBJECTIVE: To systematically compare the frequencies of intrathecal antibody production to EBV, measles virus, rubella virus, varicella zoster virus (VZV) and herpes simplex virus (HSV) in patients with MS...
February 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29093709/age-related-macular-degeneration-a-connection-between-human-herpes-virus-6a-induced-cd46-downregulation-and-complement-activation
#15
Walter Fierz
Viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system. A well-known example is the human immunodeficiency virus that uses CD4 cell surface molecules to enter host lymphocytes and thereby deleteriously destroying the helper cell population of the immune system. A more complicated mechanism is seen in multiple sclerosis (MS) where human herpes virus-6A (HHV-6A) infects astrocytes by docking to the CD46 surface receptor...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28855411/epstein-barr-virus-cytomegalovirus-and-multiple-sclerosis-susceptibility-a-multiethnic-study
#16
Annette Langer-Gould, Jun Wu, Robyn Lucas, Jessica Smith, Edlin Gonzales, Lilyana Amezcua, Samantha Haraszti, Lie Hong Chen, Hong Quach, Judith A James, Lisa F Barcellos, Anny H Xiang
OBJECTIVE: To determine whether Epstein-Barr virus (EBV) or cytomegalovirus (CMV) seropositivity is associated with multiple sclerosis (MS) in blacks and Hispanics and to what extent measures of the hygiene hypothesis or breastfeeding could explain these findings. EBV and CMV have been associated with MS risk in whites, and the timing and frequency of both viruses vary by factors implicated in the hygiene hypothesis. METHODS: Incident cases of MS or its precursor, clinically isolated syndrome (CIS), and matched controls (blacks, 111 cases/128 controls; Hispanics, 173/187; whites, 235/256) were recruited from the membership of Kaiser Permanente Southern California...
September 26, 2017: Neurology
https://www.readbyqxmd.com/read/28767147/programmed-death-1-is-highly-expressed-on-cd8-cd57-t-cells-in-patients-with-stable-multiple-sclerosis-and-inhibits-their-cytotoxic-response-to-epstein-barr-virus
#17
Maria T Cencioni, Roberta Magliozzi, Richard Nicholas, Rehiana Ali, Omar Malik, Richard Reynolds, Giovanna Borsellino, Luca Battistini, Paolo A Muraro
Growing evidence points to a deregulated response to Epstein-Barr virus (EBV) in the central nervous system of patients with multiple sclerosis (MS) as a possible cause of disease. We have investigated the response of a subpopulation of effector CD8+ T cells to EBV in 36 healthy donors and in 35 patients with MS in active and inactive disease. We have measured the expression of markers of degranulation, the release of cytokines, cytotoxicity and the regulation of effector functions by inhibitory receptors, such as programmed death 1 (PD-1) and human inhibitor receptor immunoglobulin-like transcript 2 (ILT2)...
December 2017: Immunology
https://www.readbyqxmd.com/read/28755684/epstein-barr-virus-and-multiple-sclerosis-updating-pender-s-hypothesis
#18
REVIEW
Martin Laurence, Julián Benito-León
Substantial epidemiological evidence supports the involvement of the Epstein-Barr virus (EBV) in multiple sclerosis (MS). Mechanisms through which EBV may increase MS risk are reviewed here. Most individuals contract EBV in early childhood yet only develop MS in early adulthood, by which time EBV has been latent for decades. When latent, EBV is confined to a minute subset of memory B cells: about 1000 cells in peripheral blood and 500,000 cells in the lymphoid system, mainly in the mouth. Reactivation of EBV in the central nervous system (CNS) has been proposed as a cause of MS...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755681/ebv-and-ms-major-cause-minor-contribution-or-red-herring
#19
REVIEW
Sean Burnard, Jeannette Lechner-Scott, Rodney J Scott
Multiple Sclerosis (MS) is a chronic neurological disease with genetic and environmental risk factors. Epstein Barr-Virus (EBV) has been closely associated with MS but with a significant amount of conflicting evidence. Some of the evidence for EBV involvement in MS includes: almost 100% of MS patients showing past EBV infection, an association with Infectious Mononucleosis (acute EBV infection), higher titres of EBV antibodies associated with an increased risk of MS development, and an overall altered immune response to EBV found in peripheral blood and the CNS of MS patients...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28731372/exploring-the-effect-of-vitamin-d3-supplementation-on-the-anti-ebv-antibody-response-in-relapsing-remitting-multiple-sclerosis
#20
Linda Rolf, Anne-Hilde Muris, Amandine Mathias, Renaud Du Pasquier, Inga Koneczny, Giulio Disanto, Jens Kuhle, Sreeram Ramagopalan, Jan Damoiseaux, Joost Smolders, Raymond Hupperts
BACKGROUND: Epstein-Barr virus (EBV) infection and vitamin D insufficiency are potentially interacting risk factors for multiple sclerosis (MS). OBJECTIVES: To investigate the effect of high-dose vitamin D3 supplements on antibody levels against the EBV nuclear antigen-1 (EBNA-1) in patients with relapsing-remitting multiple sclerosis (RRMS) and to explore any underlying mechanism affecting anti-EBNA-1 antibody levels. METHODS: This study utilized blood samples from a randomized controlled trial in RRMS patients receiving either vitamin D3 (14,000 IU/day; n = 30) or placebo ( n = 23) over 48 weeks...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
keyword
keyword
61956
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"