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EBV and multiple sclerosis

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https://www.readbyqxmd.com/read/27887749/angiogenic-factors-are-associated-with-multiple-sclerosis
#1
Sajad Karampoor, Hamid Zahednasab, Sreeram Ramagopalan, Masoud Mehrpour, Hossein Keyvani
A growing body of evidence suggests that angiogenesis plays a crucial role in the pathogenesis of multiple sclerosis (MS). Animal models of MS show a significant improvement when the process of angiogenesis is halted. In this study, we measured the serum levels of vascular-endothelial growth factor (VEGF), soluble Endoglin (sEng), angiopoietin 1(Ang-1), angiopoietin 2 (Ang-2), and uric acid (UA) as well as serum anti-Epstein-Barr virus (EBV) EBNA-1 IgG in 50 MS patients (including 20 newly diagnosed and 30 patients taking IFN-beta for >6months) and 40 healthy individuals...
November 17, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27878471/cerebrospinal-fluid-anti-epstein-barr-virus-specific-oligoclonal-igm-and-igg-bands-in-patients-with-clinically-isolated-and-guillain-barr%C3%A3-syndrome
#2
Diana Ferraro, Veronica Galli, Anna Maria Simone, Roberta Bedin, Francesca Vitetta, Elisa Merelli, Paolo Frigio Nichelli, Patrizia Sola
Epstein-Barr virus (EBV) has been implicated in multiple sclerosis (MS) pathogenesis. We aimed to assess the frequency of EBV-specific IgG and IgM oligoclonal bands (OCB) in cerebrospinal fluid (CSF) of 50 patients with clinically isolated syndrome (CIS) and in 27 controls with Guillain-Barré syndrome (GBS). Furthermore, we assessed correlations between the presence of OCB and CIS patients' CSF, MRI, and clinical variables. There was no difference in the proportion of CIS and GB patients with positivity for anti-EBV-specific IgG/IgM OCB...
November 22, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27836419/ebv-infection-and-multiple-sclerosis-lessons-from-a-marmoset-model
#3
REVIEW
Bert A 'tHart, Yolanda S Kap, Elena Morandi, Jon D Laman, Bruno Gran
Multiple sclerosis (MS) is thought to be initiated by the interaction of genetic and environmental factors, eliciting an autoimmune attack on the central nervous system. Epstein-Barr virus (EBV) is the strongest infectious risk factor, but an explanation for the paradox between high infection prevalence and low MS incidence remains elusive. We discuss new data using marmosets with experimental autoimmune encephalomyelitis (EAE) - a valid primate model of MS. The findings may help to explain how a common infection can contribute to the pathogenesis of MS...
December 2016: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/27833448/a-possible-link-between-the-epstein-barr-virus-infection-and-autoimmune-thyroid-disorders
#4
REVIEW
Anna Dittfeld, Katarzyna Gwizdek, Marek Michalski, Romuald Wojnicz
The Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the Herpesviridae virus family. EBV infection can cause infectious mononucleosis (IM) in the lytic phase of EBV's life cycle. Past EBV infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. Although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be responsible for their development...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27813134/establishment-and-characterization-of-a-novel-hodgkin-lymphoma-cell-line-am-hlh-carrying-the-epstein-barr-virus-genome-integrated-into-the-host-chromosome
#5
Masahiko Hayashida, Masanori Daibata, Erika Tagami, Takahiro Taguchi, Fumiyo Maekawa, Kayo Takeoka, Katsuhiro Fukutsuka, Daiki Shimomura, Takamasa Hayashi, Yoshinori Iwatani, Hitoshi Ohno
We describe the establishment and characterization of a cell line, AM-HLH, obtained from a patient with Epstein-Barr virus-positive (EBV(+) ) nodular sclerosis-type Hodgkin lymphoma (HL). The cells were positive for CD2 and CD30 and negative for CD15. The immunoglobulin heavy- and κ light-chain genes were rearranged. The karyotype was of the triploid range. Southern blotting using the EBV terminal repeat probe detected 3 hybridizing bands that were identical to those of the parental HL material. The cells expressed EBV-encoded RNAs as well as latent genes (EBNA1, EBNA2, LMP1, and LMP2A) and lytic genes (BZLF1 and BALF2)...
November 4, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27813075/disease-etiology-and-diagnosis-by-tcr-repertoire-analysis-goes-viral
#6
Meriem Attaf, Andrew K Sewell
The importance of T-cell receptor (TCR) repertoire diversity is highlighted in murine models of immunodeficiency and in many human pathologies. However, the true extent of TCR diversity and how this diversity varies in health and disease is poorly understood. In a previous issue of the European Journal of Immunology, Lossius et al. [Eur. J. Immunol. 2014. 44: 3439-3452] dissected the composition of the TCR repertoire in the context of multiple sclerosis (MS) using high-throughput sequencing of TCR-β chains in cerebrospinal fluid samples and blood...
November 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27725113/the-increased-antibody-response-to-epstein-barr-virus-in-multiple-sclerosis-is-restricted-to-selected-virus-proteins
#7
Matthew M Dooley, Samantha L de Gannes, Kristi A Fu, J William Lindsey
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, and the antibody response to EBV is reported to be increased in MS. EBV contains multiple antigens, and only a few have been investigated. Our hypothesis is that MS patients will have an increased antibody response to only selected EBV antigens. We used immunoprecipitation and quantitative mass spectrometry to identify candidate EBV antigens. We then measured the antibody response to 10 individual EBV proteins with quantitative ELISA...
October 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27663872/negative-interaction-between-smoking-and-ebv-in-the-risk-of-multiple-sclerosis-the-envims-study
#8
Kjetil Bjørnevik, Trond Riise, Inger Bostrom, Llaria Casetta, Marianna Cortese, Enrico Granieri, Trygve Holmøy, Margitta T Kampman, Anne-Marie Landtblom, Sandra Magalhaes, Maura Pugliatti, Christina Wolfson, Kjell-Morten Myhr
BACKGROUND: Results from previous studies on a possible interaction between smoking and Epstein-Barr virus (EBV) in the risk of multiple sclerosis (MS) are conflicting. OBJECTIVES: To examine the interaction between smoking and infectious mononucleosis (IM) in the risk of MS. METHODS: Within the case-control study on Environmental Factors In Multiple Sclerosis (EnvIMS), 1904 MS patients and 3694 population-based frequency-matched healthy controls from Norway, Italy, and Sweden reported on prior exposure to smoking and history of IM...
September 23, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27635051/geographic-population-structure-in-epstein-barr-virus-revealed-by-comparative-genomics
#9
Matteo Chiara, Caterina Manzari, Claudia Lionetti, Rosella Mechelli, Eleni Anastasiadou, Maria Chiara Buscarinu, Giovanni Ristori, Marco Salvetti, Ernesto Picardi, Anna Maria D'Erchia, Graziano Pesole, David S Horner
Epstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showed a statistically significant association with MS. Taking advantage of the availability of ~130 EBV genomes with known geographical origins, we reveal a striking geographic distribution of EBV sub-populations with distinct allele frequency distributions...
September 15, 2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27572857/environmental-and-genetic-factors-in-pediatric-inflammatory-demyelinating-diseases
#10
Emmanuelle Waubant, Anne-Louise Ponsonby, Maura Pugliatti, Heather Hanwell, Ellen M Mowry, Rogier Q Hintzen
The onset of multiple sclerosis (MS) occurs in childhood in about 5% of all patients with MS. The disease in adults has a complex genetic and environmental inheritability. One of the main risk factors, also confirmed in pediatric MS, is HLA DRB1*1501 In addition to genetic factors, a large part of disease susceptibility in adults is conferred by environmental risk factors such as low vitamin D status, exposure to cigarette smoking, and remote Epstein-Barr virus (EBV) infection. In children, both exposure to cigarette smoking and prior EBV infection have been reported consistently as risk factors for MS...
August 30, 2016: Neurology
https://www.readbyqxmd.com/read/27503907/increased-ex-vivo-antigen-presentation-profile-of-b-cells-in-multiple-sclerosis
#11
Amandine Mathias, Guillaume Perriard, Mathieu Canales, Charlotte Soneson, Mauro Delorenzi, Myriam Schluep, Renaud A Du Pasquier
BACKGROUND: Multiple sclerosis (MS) is thought to be T cell mediated but the mechanisms eliciting such a dysregulated adaptative immune response remain enigmatic. OBJECTIVE: To examine the activation profile of antigen-presenting cells (APCs) in MS. METHODS: A total of 98 study subjects were enrolled including patients suffering from relapsing-remitting, secondary- and primary-progressive (PP) MS, other inflammatory neurological diseases, and healthy controls...
August 8, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27412414/lymphocryptovirus-infection-of-nonhuman-primate-b-cells-converts-destructive-into-productive-processing-of-the-pathogenic-cd8-t-cell-epitope-in-myelin-oligodendrocyte-glycoprotein
#12
S Anwar Jagessar, Inge R Holtman, Sam Hofman, Elena Morandi, Nicole Heijmans, Jon D Laman, Bruno Gran, Bart W Faber, Sander I van Kasteren, Bart J L Eggen, Bert A 't Hart
EBV is the major infectious environmental risk factor for multiple sclerosis (MS), but the underlying mechanisms remain obscure. Patient studies do not allow manipulation in vivo. We used the experimental autoimmune encephalomyelitis (EAE) models in the common marmoset and rhesus monkey to model the association of EBV and MS. We report that B cells infected with EBV-related lymphocryptovirus (LCV) are requisite APCs for MHC-E-restricted autoaggressive effector memory CTLs specific for the immunodominant epitope 40-48 of myelin oligodendrocyte glycoprotein (MOG)...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27397076/fine-specificity-of-the-antibody-response-to-epstein-barr-nuclear-antigen-2-and-other-epstein-barr-virus-proteins-in-patients-with-clinically-isolated-syndrome-a-peptide-microarray-based-case-control-study
#13
Ludwig Schlemm, René Markus Giess, Ludwig Rasche, Catherina Pfuhl, Katharina Wakonig, Janina Ruth Behrens, Carmen Scheibenbogen, Judith Bellmann-Strobl, Friedemann Paul, Ulf Reimer, Klemens Ruprecht
We analyzed the fine specificity of antibodies to Epstein-Barr nuclear antigen-2 (EBNA-2) and other Epstein-Barr virus (EBV) proteins in 29 patients with clinically isolated syndrome (CIS, the first clinical manifestation of multiple sclerosis [MS]) and 29 controls with a peptide microarray containing 117 overlapping peptides representing the full-length EBNA-2 protein and 71 peptides from 8 further EBV proteins. While EBV peptide antibodies were elevated in CIS, suggesting that EBV contributes to MS early during disease development, they discriminated groups only slightly better than EBNA-1 antibodies...
August 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27383531/serum-baff-levels-methypredsinolone-therapy-epstein-barr-virus-and-mycobacterium-avium-subsp-paratuberculosis-infection-in-multiple-sclerosis-patients
#14
Giuseppe Mameli, Eleonora Cocco, Jessica Frau, Giannina Arru, Elisa Caggiu, Maria Giovanna Marrosu, Leonardo A Sechi
Elevated B lymphocyte activating factor BAFF levels have been reported in multiple sclerosis (MS) patients; moreover, disease-modifying treatments (DMT) have shown to influence blood BAFF levels in MS patients, although the significance of these changes is still controversial. In addition, BAFF levels were reported increased during infectious diseases. In our study, we wanted to investigate on the serum BAFF concentrations correlated to the antibody response against Mycobacterium avium subspecies paratuberculosis (MAP), Epstein-Barr virus (EBV) and their human homologous epitopes in MS and in patients affected with other neurological diseases (OND), divided in Inflammatory Neurological Diseases (IND), Non Inflammatory Neurological Diseases (NIND) and Undetermined Neurological Diseases (UND), in comparison to healthy controls (HCs)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27325604/effect-of-high-dose-vitamin-d3-supplementation-on-antibody-responses-against-epstein-barr-virus-in-relapsing-remitting-multiple-sclerosis
#15
Egil Røsjø, Andreas Lossius, Nada Abdelmagid, Jonas C Lindstrøm, Margitta T Kampman, Lone Jørgensen, Peter Sundström, Tomas Olsson, Linn H Steffensen, Øivind Torkildsen, Trygve Holmøy
BACKGROUND: Elevated antibody levels against Epstein-Barr virus (EBV) and a poor vitamin D status are environmental factors that may interact in relapsing-remitting multiple sclerosis (RRMS) aetiology. OBJECTIVES: To examine effects of high-dose oral vitamin D3 supplementation on antibody levels against EBV nuclear antigen 1 (EBNA1) in RRMS. METHODS: Serum 25-hydroxyvitamin D3 (25(OH)D) and immunoglobulin G antibody levels against EBNA1 (whole protein and amino acid 385-420 fragment), EBV viral capsid antigen (VCA), cytomegalovirus (CMV) and varicella zoster virus (VZV) were measured in 68 RRMS patients enrolled in a 96-week randomised double-blinded placebo-controlled clinical trial of oral vitamin D3 supplementation (20,000 IU/week) (NCT00785473)...
June 20, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27310932/natalizumab-therapy-modulates-mir-155-mir-26a-and-proinflammatory-cytokine-expression-in-ms-patients
#16
Giuseppe Mameli, Giannina Arru, Elisa Caggiu, Magdalena Niegowska, Stefania Leoni, Giordano Madeddu, Sergio Babudieri, Gian Pietro Sechi, Leonardo A Sechi
MicroRNAs fine-tune the regulation of Th1/Th17 lymphocyte subsets in multiple sclerosis. We investigated the expression of miRNAs (previously associated with mycobacterial and viral infections) in MS patients and healthy donors (HD) following 6 months natalizumab therapy. In addition, Th1/Th17 cytokines and the presence of anti-EBNA1/VCA IgG in MS patients with different pattern of miRNA expression have been evaluated. MiR-155, miR-26a, miR-132, miR-146a and Th1/Th17 cytokines expression was detected by RT-real time PCR; moreover anti-EBNA1 and VCA IgG titres were measured by ELISA...
2016: PloS One
https://www.readbyqxmd.com/read/27265253/interferon-%C3%AE-therapy-specifically-reduces-pathogenic-memory-b-cells-in-multiple-sclerosis-patients-by-inducing-a-fas-mediated-apoptosis
#17
Fabiana Rizzo, Elena Giacomini, Rosella Mechelli, Maria Chiara Buscarinu, Marco Salvetti, Martina Severa, Eliana Marina Coccia
Growing evidences put B lymphocytes on a central stage in Multiple sclerosis (MS) immunopathology. While investigating the effects of Interferon (IFN)-β therapy, one of the most used first-line disease-modifying drugs for the treatment of Relapsing-Remitting MS (RRMS), in circulating B cell subpopulations we found a specific and dramatic decrease of CD27(+) memory B cells. Interestingly, memory B cells are considered a population with a great disease-driving relevance in MS and resulted to be also target of B cell depleting therapies...
June 6, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27217468/no-association-of-multiple-sclerosis-activity-and-progression-with-ebv-or-tobacco-use-in-benefit
#18
Armando Sena, Carlos Capela, Véronique Ferret-Sena, Kassandra L Munger, Alberto Ascherio, Gustavo Suarez
No abstract text is available yet for this article.
May 24, 2016: Neurology
https://www.readbyqxmd.com/read/27142157/antibody-producing-b-lineage-cells-invade-the-central-nervous-system-predominantly-at-the-time-of-and-triggered-by-acute-epstein-barr-virus-infection-a-hypothesis-on-the-origin-of-intrathecal-immunoglobulin-synthesis-in-multiple-sclerosis
#19
Carolin Otto, Jörg Hofmann, Klemens Ruprecht
Patients with multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS), typically have an intrathecal synthesis of immunoglobulin (Ig)G. Intrathecal IgG is produced by B lineage cells that entered the CNS, but why and when these cells invade the CNS of patients with MS is unknown. The intrathecal IgG response in patients with MS is polyspecific and part of it is directed against different common viruses (e.g. measles virus, rubella virus, varicella zoster virus). Strong and consistent evidence suggests an association of MS and Epstein-Barr virus (EBV) infection and EBV seroprevalence in patients with MS is practically 100%...
June 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27120609/the-correlation-between-the-virus-and-brain-antigen-specific-b-cell-response-in-the-blood-of-patients-with-multiple-sclerosis
#20
Marie Wunsch, Christopher Hohmann, Bianca Milles, Christina Rostermund, Paul V Lehmann, Michael Schroeter, Antonios Bayas, Jochen Ulzheimer, Mathias Mäurer, Süleyman Ergün, Stefanie Kuerten
There is a largely divergent body of literature regarding the relationship between Epstein-Barr virus (EBV) infection and brain inflammation in multiple sclerosis (MS). Here, we tested MS patients during relapse (n = 11) and in remission (n = 19) in addition to n = 22 healthy controls to study the correlation between the EBV- and brain-specific B cell response in the blood by enzyme-linked immunospot (ELISPOT) and enzyme-linked immunosorbent assay (ELISA). Cytomegalovirus (CMV) was used as a control antigen tested in n = 16 MS patients during relapse and in n = 35 patients in remission...
April 2016: Viruses
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