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https://www.readbyqxmd.com/read/29179011/ivf-outcome-in-azoospermic-cancer-survivors
#1
S Dar, R Orvieto, J Levron, J Haas, Itai Gat, G Raviv
OBJECTIVE: To assess clinical outcome among infertile couples treated by in vitro fertilization (IVF) and intra cytoplasmic sperm injection (ICSI) using testicular sperm from azoospermic cancer survivors. STUDY DESIGN: This clinical retrospective study included infertile couples treated in a single tertiary referral center between 1996 and 2013. All male partners were cancer survivors who were diagnosed with azoospermia due to previous gonadotoxic treatments and referred to testicular sperm extraction (TESE)...
November 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28990672/microdissection-testicular-sperm-extraction-in-finland-results-of-the-first-100-patients
#2
Rauni Klami, Harri Mankonen, Antti Perheentupa
INTRODUCTION: Testicular microdissection sperm extraction (MD-TESE) combined with intracytoplasmic sperm injection (ICSI) has made biological fatherhood possible for many men with the most severe form of male infertility, non-obstructive azoospermia. MD-TESE was introduced in Turku in 2008, and by 2015, 100 Finnish men with non-obstructive azoospermia have been operated on. MATERIAL AND METHODS: The average age was 33 years at the time of surgery. Forty-eight had a needle biopsy previously, 56% had testicular size less than 15ml...
October 9, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28703337/paternal-age-as-an-independent-factor-does-not-affect-embryo-quality-and-pregnancy-outcomes-of-testicular-sperm-extraction-intracytoplasmic-sperm-injection-in-azoospermia
#3
Y S Park, S H Lee, C K Lim, H W Choi, J H An, C W Park, H S Lee, J S Lee, J T Seo
This study was performed to evaluate the independent influence of paternal age affecting embryo development and pregnancy using testicular sperm extraction (TESE)-intracytoplasmic sperm injection (ICSI) in obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). Paternal patients were divided into the following groups: ≤30 years, 31-35 years, 36-40 years, 41-45 years and ≥46 years. There were no differences in the rates of fertilisation or embryo quality according to paternal and maternal age...
July 13, 2017: Andrologia
https://www.readbyqxmd.com/read/28479763/microdissection-testicular-sperm-extraction-in-men-with-nonobstructive-azoospermia-experience-of-king-saud-university-medical-city-riyadh-saudi-arabia
#4
Saleh Binsaleh, Dulaim Alhajeri, Khaled Madbouly
OBJECTIVES: Microdissection testicular sperm extraction (micro-TESE) is an optimal technique of sperm extraction for intracytoplasmic sperm injection. This study is to present our experience in micro-TESE and evaluate the relation of its sperm retrieval rate (SRR) with patients' characteristics, testicular functions, and histological parameters as well as previous sperm retrieval interventions. MATERIALS AND METHODS: We retrospectively reviewed records of 255 patients with nonobstructive azoospermia who underwent micro-TESE between 2011 and 2014...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28428940/factors-influencing-sperm-retrieval-following-testicular-sperm-extraction-in-nonobstructive-azoospermia-patients
#5
Peyman Salehi, Marzieh Derakhshan-Horeh, Zakiye Nadeali, Majid Hosseinzadeh, Erfan Sadeghi, Mohammad Hossein Izadpanahi, Mansour Salehi
OBJECTIVE: Azoospermia owing to testicular disorders is the most severe manifestation of male infertility. The main concern for patients with nonobstructive azoospermia (NOA) is the probability of successful sperm retrieval following testicular sperm extraction (TESE). Therefore, the goal of this study was to determine predictive factors correlated with sperm retrieval. METHODS: We assessed the testicular histopathological patterns, the choice of TESE surgical procedure, hormone levels, and chromosomal abnormalities in patients with NOA (n=170)...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28392002/does-cryopreservation-of-sperm-affect-fertilization-in-nonobstructive-azoospermia-or-cryptozoospermia
#6
COMPARATIVE STUDY
Natali Schachter-Safrai, Gilad Karavani, Eliahu Levitas, Michael Friger, Atif Zeadna, Eitan Lunenfeld, Iris Har-Vardi
OBJECTIVE: To compare intracytoplasmic sperm injection (ICSI) outcomes with the use of fresh or frozen-thawed ejaculated or testicular sperm in patients with cryptozoospermia or nonobstructive azoospermia. DESIGN: Retrospective cohort study. SETTING: Tertiary medical center IVF unit. PATIENT(S): A total of 274 patients evaluated from 1999 to 2011. INTERVENTION(S): A total of 103 patients underwent testicular sperm extraction (TESE) because of nonobstructive azoospermia, and 171 patients were diagnosed with cryptozoospermia...
May 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28379559/sperm-recovery-and-icsi-outcomes-in-klinefelter-syndrome-a-systematic-review-and-meta-analysis
#7
REVIEW
Giovanni Corona, Alessandro Pizzocaro, Fabio Lanfranco, Andrea Garolla, Fiore Pelliccione, Linda Vignozzi, Alberto Ferlin, Carlo Foresta, Emmanuele A Jannini, Mario Maggi, Andrea Lenzi, Daniela Pasquali, Sandro Francavilla
BACKGROUND: Specific factors underlying successful surgical sperm retrieval rates (SRR) or pregnancy rates (PR) after testicular sperm extraction (TESE) in adult patients with Klinefelter syndrome (KS) have not been completely clarified. OBJECTIVE AND RATIONALE: The aim of this review was to meta-analyse the currently available data from subjects with KS regarding SRRs as the primary outcome. In addition, when available, PRs and live birth rates (LBRs) after the ICSI technique were also investigated as secondary outcomes...
May 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28331619/processing-and-selection-of-surgically-retrieved-sperm-for-icsi-a-review
#8
Greta Verheyen, Biljana Popovic-Todorovic, Herman Tournaye
Although the technique of intracytoplasmic sperm injection (ICSI) has been a revolution in the alleviation of male infertility, the use of testicular sperm for ICSI was a formerly unseen breakthrough in the treatment of the azoospermic man with primary testicular failure. At the clinical level, different procedures of testicular sperm retrieval (conventional TESE, micro-TESE, FNA/TESA, MESA, PESA) are being performed, the choice is mainly based on the cause of azoospermia (obstructive versus non-obstructive) and the surgeon's skills...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/27896242/intracytoplasmic-sperm-injection-outcomes-with-freshly-ejaculated-sperms-and-testicular-or-epididymal-sperm-extraction-in-patients-with-idiopathic-cryptozoospermia
#9
Ali Asghar Ketabchi
BACKGROUND: Cryptozoospermia (CO) is a situation in which spermatozoa cannot be observed in a fresh semen sample unless an extended centrifugation and microscopic search are performed. CO patients are suggested to use only intracytoplasmic sperm injection (ICSI) as infertility treatment. But still there is debate about the choice of sperm source in cryptozoospermic men candidate for ICSI. OBJECTIVES: This study was conducted to evaluate fertility outcomes in men with idiopathic cryptozoospermia who were treated using ICSI with freshly ejaculated sperm and testis sperm extraction (TESE) or percutaneous epididymal sperm aspiration (PESA)...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27894976/comparison-of-the-clinical-outcomes-of-intracytoplasmic-sperm-injection-between-spermatozoa-retrieved-from-testicular-biopsy-and-from-ejaculate-in-cryptozoospermia-patients
#10
Xianfeng Cui, Pan Ding, Ge Gao, Yunshan Zhang
OBJECTIVE: To compare the clinical outcomes of intracytoplasmic sperm injection (ICSI) between spermatozoa retrieved from testicular biopsy and from ejaculate in cryptozoospermia patients. MATERIALS AND METHODS: The clinical data of 285 cryptozoospermia patients who underwent ICSI treatment in our center during the period from March 2009 to November 2013 were retrospectively analyzed. Within them, ejaculated sperms were used in 214 cases (group 1), and testicular sperms extracted by testicular sperm aspiration or conventional testis dissection sperm extraction were used in 71 cases (group 2)...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27833987/pregnancy-resulting-from-imsi-after-testicular-biopsy-in-a-patient-with-obstructive-azoospermia
#11
Constantin Cristian Văduva, Carmen Constantinescu, Mihaela Mirela Radu, Alice Roxana Văduva, Andrei Pănuş, Mihaela Ţenovici, Damian DiŢescu, Dinu Florin Albu
In this article, we report a case of pregnancy obtained in an infertile couple diagnosed with severe male factor infertility. The couple attended for fertility examination reporting a history of 10 years of infertility. The cause of infertility was obstructive azoospermia. The treatment consists of in vitro fertilization (IVF). The ovarian stimulation of female patient was done with antagonist protocol and after ovarian puncture was obtained nine oocytes. The urologist performed testicular sperm extraction (TESE)...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27793367/behavioral-cognitive-and-motor-performance-and-physical-development-of-five-year-old-children-who-were-born-after-intracytoplasmic-sperm-injection-with-the-use-of-testicular-sperm
#12
MULTICENTER STUDY
Aukje M Meijerink, Liliana Ramos, Anjo J W M Janssen, Nienke M Maas-van Schaaijk, Andreas Meissner, Sjoerd Repping, Monique H Mochtar, Didi D M Braat, Kathrin Fleischer
OBJECTIVE: To evaluate at the age of 5 years the behavioral, cognitive, and motor performance and physical development of children born after testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI). DESIGN: A prospective longitudinal cohort study. SETTING: Two university medical centers. PATIENT(S): A total of 103 5-year-olds who were born after TESE-ICSI. INTERVENTION(S): The follow-up of the children was performed by questionnaires at birth and again at 1 year and at 4 years of age...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27785898/outcome-of-intracytoplasmic-sperm-injection-using-fresh-and-cryopreserved-thawed-test%C3%A4-cular-spermatozoa-in-83-azoospermic-men-with-klinefelter-syndrome
#13
Kubilay Vicdan, Cem Akarsu, Eran Sözen, Burcu Buluç, Arzu Vicdan, Yıldırım Yılmaz, Kutay Biberoğlu
AIM: To report the outcome of intracytoplasmic sperm injection (ICSI) cycles using fresh or cryopreserved-thawed testicular spermatozoa of men with Klinefelter syndrome (KS). METHODS: Medical records of 83 azoospermic men with KS who underwent testicular sperm extraction (TESE) were reviewed. The clinical parameters for predicting sperm retrieval and fertilization, implantation, pregnancy and live birth rates of ICSI cycles in these patients were evaluated. RESULTS: A total of 88 TESE procedures were performed with sperm retrieval rates of 39...
November 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27646677/improving-icsi-a-review-from-the-spermatozoon-perspective
#14
REVIEW
Mara Simopoulou, Laertis Gkoles, Panagiotis Bakas, Polina Giannelou, Theodoros Kalampokas, Konstantinos Pantos, Michael Koutsilieris
Intracytoplasmic sperm injection (ICSI) is the most frequently applied method for fertilization making the process of identifying the perfect spermatozoon fundamental. Herein we offer a critical and thorough presentation on the techniques reported regarding (i) handling and preparing semen samples, (ii) identifying and 'fishing' spermatozoa, and (iii) improving key factors, such as motility for a successful ICSI practice. These approaches are suggested to make the process easier and more effective especially in atypical and challenging circumstances...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27538137/-outcome-of-treatment-of-y-chromosome-azfc-microdeletion-patients
#15
L M Zhao, H Jiang, K Hong, H C Lin, W H Tang, D F Liu, J M Mao, Y Lian, L L Ma
OBJECTIVE: To discuss the treatment options for patients with azoospermia factor (AZF) c microdeletion on Y chromosome. METHODS: One hundred and eighty three patients, who were diagnosed as AZFc microdeletion on Y chromosome in Peking University Third Hospital, were recruited in our study. In order to get better treatment option for this kind of patients, we retrospectively analyzed their clinic data including the treatment process and pregnancy outcome and found out the characteristics of their semen...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27526630/undergoing-varicocele-repair-before-assisted-reproduction-improves-pregnancy-rate-and-live-birth-rate-in-azoospermic-and-oligospermic-men-with-a-varicocele-a-systematic-review-and-meta-analysis
#16
REVIEW
E Will Kirby, Laura Elizabeth Wiener, Saneal Rajanahally, Karen Crowell, Robert M Coward
OBJECTIVE: To evaluate how varicocele repair (VR) impacts pregnancy (PRs) and live birth rates in infertile couples undergoing assisted reproduction wherein the male partner has oligospermia or azoospermia and a history of varicocele. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Azoospermic and oligospermic males with varicoceles and in couples undergoing assisted reproductive technology (ART) with IUI, IVF, or testicular sperm extraction (TESE) with IVF and intracytoplasmic sperm injection (ICSI)...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27416674/-predictive-factors-of-testicular-sperm-extraction-in-men-with-non-obstructive-azoospermia
#17
REVIEW
Huan-li Yang, Xiu-juan Shao, Yi-yang Zhu, Wei-ling Wu
Men with non-obstructive azoospermia (NOA) can achieve fertility by testicular sperm extraction (TESE) coupled with intracytoplasmic sperm injection (ICSI), the key to which is the successful retrieval of sperm from the testis. Although improved testicular sperm extraction techniques have increased the chances of sperm retrieval, to predict preoperatively the success of sperm retrieval from NOA patients remains challenging. A non-invasive diagnostic technique predicting the presence of sperm in the testis would be useful for avoiding possible surgical intervention...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/27406950/prediction-model-for-obtaining-spermatozoa-with-testicular-sperm-extraction-in-men-with-non-obstructive-azoospermia
#18
M Cissen, A M Meijerink, K W D'Hauwers, A Meissner, N van der Weide, M H Mochtar, A A de Melker, L Ramos, S Repping, D D M Braat, K Fleischer, M van Wely
STUDY QUESTION: Can an externally validated model, based on biological variables, be developed to predict successful sperm retrieval with testicular sperm extraction (TESE) in men with non-obstructive azoospermia (NOA) using a large nationwide cohort? SUMMARY ANSWER: Our prediction model including six variables was able to make a good distinction between men with a good chance and men with a poor chance of obtaining spermatozoa with TESE. WHAT IS KNOWN ALREADY: Using ICSI in combination with TESE even men suffering from NOA are able to father their own biological child...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27406949/prediction-model-for-live-birth-in-icsi-using-testicular-extracted-sperm
#19
A M Meijerink, M Cissen, M H Mochtar, K Fleischer, I Thoonen, A A de Melker, A Meissner, S Repping, D D M Braat, M van Wely, L Ramos
STUDY QUESTION: Which parameters have a predictive value for live birth in couples undergoing ICSI after successful testicular sperm extraction (TESE-ICSI)? SUMMARY ANSWER: Female age, a first or subsequent started TESE-ICSI cycle, male LH, male testosterone, motility of the spermatozoa during the ICSI procedure and the initial male diagnosis before performing TESE were identified as relevant and independent parameters for live birth after TESE-ICSI. WHAT IS KNOWN ALREADY: In reproductive medicine prediction models are used frequently to predict treatment success, but no prediction model currently exists for live birth after TESE-ICSI...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27306218/microdissection-testicular-sperm-extraction-in-japanese-patients-with-persistent-azoospermia-after-chemotherapy
#20
Takeshi Shin, Tomohiro Kobayashi, Yukihito Shimomura, Toshiyuki Iwahata, Keisuke Suzuki, Takashi Tanaka, Mai Fukushima, Megumi Kurihara, Akane Miyata, Yoshitomo Kobori, Hiroshi Okada
BACKGROUND: Combinations of surgery, radiation therapy, and chemotherapy can achieve high remission rates in patients with cancer, but these treatments can have damaging effects on spermatogenesis. In particular, cytotoxic chemotherapy may lead to irreversible spermatogenic dysfunction. Microdissection testicular sperm extraction (micro-TESE) is the only method that can address infertility in cancer survivors with persistent postchemotherapy azoospermia. METHODS: We included 66 Japanese patients with postchemotherapy azoospermia who underwent micro-TESE for sperm retrieval in this analysis...
December 2016: International Journal of Clinical Oncology
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