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Mary Leonard

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https://www.readbyqxmd.com/read/29140155/persistent-prevention-of-oxaliplatin-induced-peripheral-neuropathy-using-calmangafodipir-pledox-%C3%A2-a-placebo-controlled-randomised-phase-ii-study-pliant
#1
Bengt Glimelius, Nebojsa Manojlovic, Per Pfeiffer, Baadur Mosidze, Galina Kurteva, Mia Karlberg, Devalingam Mahalingam, Peter Buhl Jensen, Jan Kowalski, Marie Bengtson, Malin Nittve, Jacques Näsström
PURPOSE: Oxaliplatin causes disabling acute and chronic peripheral neuropathy. We explored the preventive effects of calmangafodipir, mimicking the mitochondrial enzyme manganese superoxide dismutase, thereby protecting cells from oxidative stress, in a placebo-controlled, double-blinded randomised phase II study (ClinicalTrials.gov.NCT01619423) in patients with metastatic colorectal cancer (mCRC). PATIENT AND METHODS: mCRC patients treated with modified FOLFOX-6 (folinic acid 200 mg/m(2), 5-fluorouracil bolus 400 mg/m(2), oxaliplatin 85 mg/m(2) and 5-fluorouracil 2400 mg/m(2) continuous infusion for 46 h) every fortnight for 8 cycles in first or second line were eligible...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29109701/microbial-community-and-biochemical-dynamics-of-biological-soil-crusts-across-a-gradient-of-surface-coverage-in-the-central-mojave-desert
#2
Rakesh Mogul, Parag Vaishampayan, Mina Bashir, Chris P McKay, Keith Schubert, Rosalba Bornaccorsi, Ernesto Gomez, Sneha Tharayil, Geoffrey Payton, Juliana Capra, Jessica Andaya, Leonard Bacon, Emily Bargoma, David Black, Katie Boos, Michaela Brant, Michael Chabot, Danny Chau, Jessica Cisneros, Geoff Chu, Jane Curnutt, Jessica DiMizio, Christian Engelbrecht, Caroline Gott, Raechel Harnoto, Ruben Hovanesian, Shane Johnson, Britne Lavergne, Gabriel Martinez, Paul Mans, Ernesto Morales, Alex Oei, Gary Peplow, Ryan Piaget, Nicole Ponce, Eduardo Renteria, Veronica Rodriguez, Joseph Rodriguez, Monica Santander, Khamille Sarmiento, Allison Scheppelmann, Gavin Schroter, Devan Sexton, Jenin Stephenson, Kristin Symer, Tatiane Russo-Tait, Bill Weigel, Mary B Wilhelm
In this study, we expand upon the biogeography of biological soil crusts (BSCs) and provide molecular insights into the microbial community and biochemical dynamics along the vertical BSC column structure, and across a transect of increasing BSC surface coverage in the central Mojave Desert, CA, United States. Next generation sequencing reveals a bacterial community profile that is distinct among BSCs in the southwestern United States. Distribution of major phyla in the BSC topsoils included Cyanobacteria (33 ± 8%), Proteobacteria (26 ± 6%), and Chloroflexi (12 ± 4%), with Phormidium being the numerically dominant genus...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29059687/synopsis-of-the-2017-u-s-department-of-veterans-affairs-u-s-department-of-defense-clinical-practice-guideline-management-of-type-2-diabetes-mellitus
#3
Paul R Conlin, Jeffrey Colburn, David Aron, Rose Mary Pries, Mark P Tschanz, Leonard Pogach
Description: In April 2017, the U.S. Department of Veterans Affairs (VA) and the U.S. Department of Defense (DoD) approved a joint clinical practice guideline for the management of type 2 diabetes mellitus. Methods: The VA/DoD Evidence-Based Practice Work Group convened a joint VA/DoD guideline development effort that included a multidisciplinary panel of practicing clinician stakeholders and conformed to the Institute of Medicine's tenets for trustworthy clinical practice guidelines...
November 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29032290/inferential-language-use-by-youth-with-down-syndrome-during-narration
#4
Shealyn A Ashby, Marie Moore Channell, Leonard Abbeduto
We examined inferential language use by youth with Down syndrome (DS) in the context of narrative storytelling relative to younger typically developing (TD) children and same-aged peers with fragile X syndrome (FXS) matched on nonverbal cognitive ability level. Participants' narratives were coded for the use of different types of inferential language. Participants with DS used proportionately less inferential language overall relative to their counterparts with TD or FXS, although mean length of utterance accounted for group differences observed for the DS-TD group comparison only...
December 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28988207/leg-lean-mass-correlates-with-exercise-systemic-output-in-young-fontan-patients
#5
Catherine M Avitabile, David J Goldberg, Mary B Leonard, Zhenglun Alan Wei, Elaine Tang, Stephen M Paridon, Ajit P Yoganathan, Mark A Fogel, Kevin K Whitehead
OBJECTIVE: We previously described lower leg lean mass Z-scores (LLMZ) in Fontan patients associated with worse peak oxygen consumption on metabolic exercise testing. We hypothesised that LLMZ correlates with indexed systemic flow (Qsi) and cardiac index (CI) on exercise cardiac magnetic resonance (eCMR). METHODS: Thirteen patients had LLM measured by dual-energy X-ray absorptiometry within mean 40 (range 0-258) days of eCMR. LLM was converted to sex and race-specific Z-scores based on healthy reference data...
October 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28969435/patterns-of-sedentary-time-and-ambulatory-physical-activity-in-a-danish-population-of-girls-and-women-with-rett-syndrome
#6
Michelle Stahlhut, Jenny Downs, Mette Aadahl, Helen Leonard, Anne-Marie Bisgaard, Eva Nordmark
BACKGROUND: Rett syndrome (RTT) is a rare neurodevelopmental disorder leading to multiple disabilities and high dependency on caregivers. This study aimed to: (1) describe the patterns of sedentary time and daily steps and (2) identify the association of individual and environmental characteristics with sedentary time. METHODS: All Danish females with RTT older than 5 years of age and with a MECP2 mutation were invited to participate. The activPAL and StepWatch Activity Monitor (SAM) were worn by participants for at least four days...
October 2, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28968759/safety-and-immunogenicity-of-pennvax%C3%A2-g-dna-prime-administered-by-biojector%C3%A2-2000-or-cellectra%C3%A2-electroporation-device-with-modified-vaccinia-ankara-cmdr-boost
#7
Julie A Ake, Alexandra Schuetz, Poonam Pegu, Lindsay Wieczorek, Michael A Eller, Hannah Kibuuka, Fredrick Sawe, Leonard Maboko, Victoria Polonis, Nicos Karasavva, David Weiner, Arthur Sekiziyivu, Josphat Kosgei, Marco Missanga, Arne Kroidl, Philipp Mann, Silvia Ratto-Kim, Leigh Anne Eller, Patricia Earl, Bernard Moss, Julie Dorsey-Spitz, Mark Milazzo, G Laissa Ouedraogo, Farrukh Rizvi, Jian Yan, Amir S Khan, Sheila Peel, Niranjan Y Sardesai, Nelson L Michael, Viseth Ngauy, Mary Marovich, Merlin L Robb
Background: We report the first-in-human safety and immunogenicity evaluation of PENNVAX®-G DNA/ MVA-CMDR prime-boost HIV vaccine, with intramuscular DNA delivery by either Biojector® 2000 needle free injection system (Biojector) or by CELLECTRA® electroporation device. Methods: Healthy, HIV-uninfected adults were randomized to receive 4 mg PENNVAX®-G DNA delivered IM by Biojector or electroporation at baseline and week 4 followed by IM injection of 108 pfu MVA-CMDR at week 12 and 24...
September 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28958026/estimation-of-skeletal-muscle-mass-relative-to-adiposity-improves-prediction-of-physical-performance-and-incident-disability
#8
Joshua F Baker, Jin Long, Mary B Leonard, Tamara Harris, Matthew J Delmonico, Adam Santanasto, Suzanne Satterfield, Babette Zemel, David R Weber
Purpose: We assessed the discrimination of lean mass estimates that have been adjusted for adiposity for physical functioning deficits and prediction of incident disability. Methods: Included were 2,846 participants from the Health, Aging and Body Composition Study with available whole-body dual energy absorptiometry measures of appendicular lean mass index (ALMI, kg/m2) and fat mass index (FMI, kg/m2). Age-, sex-, and race-specific Z-Scores and T-Scores were determined by comparison to published reference ranges...
July 29, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28953865/corrigendum-whole-genome-landscape-of-pancreatic-neuroendocrine-tumours
#9
Aldo Scarpa, David K Chang, Katia Nones, Vincenzo Corbo, Ann-Marie Patch, Peter Bailey, Rita T Lawlor, Amber L Johns, David K Miller, Andrea Mafficini, Borislav Rusev, Maria Scardoni, Davide Antonello, Stefano Barbi, Katarzyna O Sikora, Sara Cingarlini, Caterina Vicentini, Skye McKay, Michael C J Quinn, Timothy J C Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne McLean, Craig Nourse, Ehsan Nourbakhsh, Peter J Wilson, Matthew J Anderson, J Lynn Fink, Felicity Newell, Nick Waddell, Oliver Holmes, Stephen H Kazakoff, Conrad Leonard, Scott Wood, Qinying Xu, Shivashankar Hiriyur Nagaraj, Eliana Amato, Irene Dalai, Samantha Bersani, Ivana Cataldo, Angelo P Dei Tos, Paola Capelli, Maria Vittoria Davì, Luca Landoni, Anna Malpaga, Marco Miotto, Vicki L J Whitehall, Barbara A Leggett, Janelle L Harris, Jonathan Harris, Marc D Jones, Jeremy Humphris, Lorraine A Chantrill, Venessa Chin, Adnan M Nagrial, Marina Pajic, Christopher J Scarlett, Andreia Pinho, Ilse Rooman, Christopher Toon, Jianmin Wu, Mark Pinese, Mark Cowley, Andrew Barbour, Amanda Mawson, Emily S Humphrey, Emily K Colvin, Angela Chou, Jessica A Lovell, Nigel B Jamieson, Fraser Duthie, Marie-Claude Gingras, William E Fisher, Rebecca A Dagg, Loretta M S Lau, Michael Lee, Hilda A Pickett, Roger R Reddel, Jaswinder S Samra, James G Kench, Neil D Merrett, Krishna Epari, Nam Q Nguyen, Nikolajs Zeps, Massimo Falconi, Michele Simbolo, Giovanni Butturini, George Van Buren, Stefano Partelli, Matteo Fassan, Kum Kum Khanna, Anthony J Gill, David A Wheeler, Richard A Gibbs, Elizabeth A Musgrove, Claudio Bassi, Giampaolo Tortora, Paolo Pederzoli, John V Pearson, Nicola Waddell, Andrew V Biankin, Sean M Grimmond
This corrects the article DOI: 10.1038/nature21063.
October 26, 2017: Nature
https://www.readbyqxmd.com/read/28948719/behavioral-and-psychological-phenotyping-of-physical-activity-and-sedentary-behavior-implications-for-weight-management
#10
REVIEW
Angela D Bryan, John M Jakicic, Christine M Hunter, Mary E Evans, Susan Z Yanovski, Leonard H Epstein
OBJECTIVE: Risk for obesity is determined by a complex mix of genetics and lifetime exposures at multiple levels, from the metabolic milieu to psychosocial and environmental influences. These phenotypic differences underlie the variability in risk for obesity and response to weight management interventions, including differences in physical activity and sedentary behavior. METHODS: As part of a broader effort focused on behavioral and psychological phenotyping in obesity research, the National Institutes of Health convened a multidisciplinary workshop to explore the state of the science in behavioral and psychological phenotyping in humans to explain individual differences in physical activity, both as a risk factor for obesity development and in response to activity-enhancing interventions...
October 2017: Obesity
https://www.readbyqxmd.com/read/28931804/cross-ethnic-meta-analysis-identifies-association-of-the-gpx3-tnip1-locus-with-amyotrophic-lateral-sclerosis
#11
Beben Benyamin, Ji He, Qiongyi Zhao, Jacob Gratten, Fleur Garton, Paul J Leo, Zhijun Liu, Marie Mangelsdorf, Ammar Al-Chalabi, Lisa Anderson, Timothy J Butler, Lu Chen, Xiang-Ding Chen, Katie Cremin, Hong-Weng Deng, Matthew Devine, Janette Edson, Jennifer A Fifita, Sarah Furlong, Ying-Ying Han, Jessica Harris, Anjali K Henders, Rosalind L Jeffree, Zi-Bing Jin, Zhongshan Li, Ting Li, Mengmeng Li, Yong Lin, Xiaolu Liu, Mhairi Marshall, Emily P McCann, Bryan J Mowry, Shyuan T Ngo, Roger Pamphlett, Shu Ran, David C Reutens, Dominic B Rowe, Perminder Sachdev, Sonia Shah, Sharon Song, Li-Jun Tan, Lu Tang, Leonard H van den Berg, Wouter van Rheenen, Jan H Veldink, Robyn H Wallace, Lawrie Wheeler, Kelly L Williams, Jinyu Wu, Xin Wu, Jian Yang, Weihua Yue, Zong-Hong Zhang, Dai Zhang, Peter G Noakes, Ian P Blair, Robert D Henderson, Pamela A McCombe, Peter M Visscher, Huji Xu, Perry F Bartlett, Matthew A Brown, Naomi R Wray, Dongsheng Fan
Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele frequency patterns across ethnic groups may increase gene-mapping resolution. Here we use cross-ethnic genetic data in sporadic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disease. We report analyses of novel genome-wide association study data of 1,234 ALS cases and 2,850 controls...
September 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916544/muscle-deficits-in-rheumatoid-arthritis-contribute-to-inferior-cortical-bone-structure-and-trabecular-bone-mineral-density
#12
Joshua F Baker, Jin Long, Sogol Mostoufi-Moab, Michele Denburg, Erik Jorgenson, Prerna Sharma, Babette S Zemel, Elena Taratuta, Said Ibrahim, Mary B Leonard
OBJECTIVE: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone deficits in patients with RA and healthy controls. METHODS: Participants, ages 18-75 years, completed whole-body dual-energy x-ray absorptiometry and peripheral quantitative computed tomography (pQCT) of the tibia to quantify appendicular lean mass and fat mass indices (ALMI, FMI), muscle density at the lower leg, trabecular bone density, and cortical bone thickness...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28914445/the-prevalence-of-mental-health-disorders-and-symptoms-in-children-and-adolescents-with-cerebral-palsy-a-systematic-review-and-meta-analysis
#13
REVIEW
Jenny Downs, Amanda Marie Blackmore, Amy Epstein, Rachel Skoss, Katherine Langdon, Peter Jacoby, Andrew J O Whitehouse, Helen Leonard, Peter W Rowe, Emma J Glasson
AIM: Mental health conditions and problems are often reported in children and adolescents with cerebral palsy (CP). A systematic review was undertaken to describe their prevalence. METHOD: MEDLINE and PsycINFO databases from 1996 to 2016 were searched and reference lists of selected studies were reviewed. Studies were included if they reported point prevalence of mental health diagnoses or symptoms in a general population of children and/or adolescents with CP. Pooled prevalence for mental health symptoms was determined using a random effects meta-analysis...
September 15, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28911278/measurement-of-sedentary-behaviors-or-downtime-in-rett-syndrome
#14
Michelle Stahlhut, Kylie Hill, Anne-Marie Bisgaard, Anne Kjersgaard Jensen, Michaela Andersen, Helen Leonard, Jenny Downs
This study aimed to validate measures of sedentary time in individuals with Rett syndrome. Twenty-six individuals (median [IQR] age 16.0 (9.4-20.6) years) wore an activPAL accelerometer during video-taped activities and agreement was determined between sedentary time determined by the activPAL and observation. For 11 individuals (median [IQR] age 14.5 (11.5-25.6) years), linear regression was used to determine the relationship between sedentary time recorded on the modified Bouchard activity record diary card and measured using the activPAL...
October 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28893446/use-of-an-annual-art-competition-to-promote-web-site-traffic-and-engage-children-in-antimicrobial-stewardship-in-pennsylvania
#15
Nkuchia M M'ikanatha, Courtney Yealy, Anna-Marie Warrington, Tabitha Reefer, Sameh W Boktor, Natalie Mueller, Mary Leonard, Nicole M Hackman
We used Google Analytics to assess whether annual kids' art competitions changed traffic to a Web site on appropriate antibiotic use. We found that announcements about kids' art competitions correlated with increased traffic to the Web site, suggesting that this innovation has promise in promoting antimicrobial stewardship efforts.
September 8, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28884881/effects-of-a-randomized-weight-loss-intervention-trial-in-obese-adolescents-on-tibia-and-radius-bone-geometry-and-volumetric-density
#16
Jennifer C Kelley, Nicolas Stettler-Davis, Mary B Leonard, Douglas Hill, Brian H Wrotniak, Justine Shults, Virginia A Stallings, Robert Berkowitz, Melissa S Xanthopoulos, Elizabeth Prout-Parks, Sarah B Klieger, Babette S Zemel
Obese adolescents have increased fracture risk, but effects of alterations in adiposity on bone accrual and strength in obese adolescents are not understood. We evaluated 12-month changes in trabecular and cortical volumetric bone mineral density (vBMD) and cortical geometry in obese adolescents undergoing a randomized weight management program, and investigated the effect of body composition changes on bone outcomes. Peripheral quantitative CT of the radius and tibia, and whole body DXA scans were obtained at baseline, six and 12 months in 91 obese adolescents randomized to standard care versus behavioral intervention for weight loss...
September 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28866107/baseline-features-of-the-severe-asthma-research-program-sarp-iii-cohort-differences-with-age
#17
W Gerald Teague, Brenda R Phillips, John V Fahy, Sally E Wenzel, Anne M Fitzpatrick, Wendy C Moore, Annette T Hastie, Eugene R Bleecker, Deborah A Meyers, Stephen P Peters, Mario Castro, Andrea M Coverstone, Leonard B Bacharier, Ngoc P Ly, Michael C Peters, Loren C Denlinger, Sima Ramratnam, Ronald L Sorkness, Benjamin M Gaston, Serpil C Erzurum, Suzy A A Comhair, Ross E Myers, Joe Zein, Mark D DeBoer, Anne-Marie Irani, Elliot Israel, Bruce Levy, Juan Carlos Cardet, Wanda Phipatanakul, Jonathan M Gaffin, Fernando Holguin, Merritt L Fajt, Shean J Aujla, David T Mauger, Nizar N Jarjour
BACKGROUND: The effect of age on asthma severity is poorly understood. OBJECTIVES: The objective of this study was to compare the baseline features of severe and nonsevere asthma in the Severe Asthma Research Program (SARP) III cohort, and examine in cross section the effects of age on those features. METHODS: SARP III is a National Institutes of Health/National Heart Lung Blood Institute multisite 3-year cohort study conducted to investigate mechanisms of severe asthma...
August 30, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28843635/can-we-quickly-and-thoroughly-assess-pain-with-the-pacslac-ii-a-convergent-validity-study-in-long-term-care-residents-suffering-from-dementia
#18
Mélanie Ruest, Monique Bourque, Sarah Laroche, Marie-Philippe Harvey, Marylie Martel, Kayla Bergeron-Vézina, Catherine Apinis, Dominique Proulx, Thomas Hadjistavropoulos, Yannick Tousignant-Laflamme, Guillaume Léonard
A previous study found that the modified version of the Pain Assessment Checklist for Seniors with Limited Ability to Communicate (PACSLAC-II) is a valid tool to assess pain in elderly individuals suffering from dementia and who are unable to communicate verbally. The primary objective of this study was to confirm the convergent validity of the PACSLAC-II using direct evaluation of long-term care residents in real-life situations, using two other well-validated pain assessment scales (i.e., PACSLAC and Pain Assessment in Advanced Dementia [PAINAD])...
August 23, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28813542/the-african-cholera-surveillance-network-africhol-consortium-meeting-10-11-june-2015-lom%C3%A3-togo
#19
Aline Munier, Berthe-Marie Njanpop-Lafourcade, Delphine Sauvageot, Raymond B Mhlanga, Léonard Heyerdahl, Johara Nadri, Richard Wood, Issaka Ouedraogo, Alexandre Blake, Laurent Akilimali Mukelenge, Jean-Claude B Anné, Abiba Banla Kere, Lucienne Dempouo, Sakoba Keita, José P M Langa, Issa Makumbi, Elibariki R Mwakapeje, Ian J Njeru, Olubunmi E Ojo, Isaac Phiri, Lorenzo Pezzoli, Bradford D Gessner, Martin Mengel
The fifth annual meeting of the African cholera surveillance network (Africhol) took place on 10-11 June 2015 in Lomé, Togo. Together with international partners, representatives from the 11 member countries -Cameroon, Côte d'Ivoire, Democratic Republic of Congo, Guinea, Kenya, Mozambique, Nigeria, Tanzania, Togo, Uganda, Zimbabwe- and an invited country (Malawi) shared their experience. The meeting featured three sessions: i) cholera surveillance, prevention and control in participating countries, ii) cholera surveillance methodology, such as cholera mapping, cost-effectiveness studies and the issue of overlapping epidemics from different diseases, iii) cholera laboratory diagnostics tools and capacity building...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28802058/postantibiotic-effect-and-postantibiotic-sub-mic-effect-of-ltx-109-and-mupirocin-on-staphylococcus-aureus-blood-isolates
#20
L D Saravolatz, J Pawlak, H Martin, S Saravolatz, L Johnson, H Wold, M Husbyn, W M Olsen
The development of new synthetic antimicrobial peptides like LTX-109 provides a new class of drugs for the treatment of Staphylococcus aureus infections. We evaluated LTX-109 and mupirocin for pharmacodynamic parameters against 10 methicillin-resistant S. aureus isolates. The postantibiotic effect (PAE) is defined as the length of time that bacterial growth is suppressed following a brief exposure to an antibiotic. We also determined the sub-MIC effect (SME) which measures the direct effect of subinhibitory levels on strains that have not previously been exposed to antibiotics...
August 12, 2017: Letters in Applied Microbiology
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