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Glenn Chertow

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https://www.readbyqxmd.com/read/27897415/sarcopenia-among-patients-receiving-hemodialysis-weighing-the-evidence
#1
Piyawan Kittiskulnam, Juan J Carrero, Glenn M Chertow, George A Kaysen, Cynthia Delgado, Kirsten L Johansen
BACKGROUND: There is no consensus on how best to define low muscle mass in patients with end-stage renal disease. Use of muscle mass normalized to height-squared has been suggested by geriatric societies but may underestimate sarcopenia, particularly in the setting of excess adiposity. We compared four definitions of low muscle mass in a prevalent hemodialysis cohort. METHODS: ACTIVE/ADIPOSE enrolled prevalent patients receiving hemodialysis from the San Francisco and Atlanta areas from June 2009 to August 2011...
August 11, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27856087/hemodialysis-hospitalizations-and-readmissions-the-effects-of-payment-reform
#2
Kevin F Erickson, Wolfgang C Winkelmayer, Glenn M Chertow, Jay Bhattacharya
BACKGROUND: In 2004, the Centers for Medicare & Medicaid Services changed reimbursement for physicians and advanced practitioners caring for patients receiving hemodialysis from a capitated to a tiered fee-for-service system, encouraging increased face-to-face visits. This early version of a pay-for-performance initiative targeted a care process: more frequent provider visits in hemodialysis. Although more frequent provider visits in hemodialysis are associated with fewer hospitalizations and rehospitalizations, it is unknown whether encouraging more frequent visits through reimbursement policy also yielded these benefits...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27831510/consolidation-in-the-dialysis-industry-patient-choice-and-local-market-competition
#3
Kevin F Erickson, Yuanchao Zheng, Wolfgang C Winkelmayer, Vivian Ho, Jay Bhattacharya, Glenn M Chertow
The Medicare program insures >80% of patients with ESRD in the United States. An emphasis on reducing outpatient dialysis costs has motivated consolidation among dialysis providers, with two for-profit corporations now providing dialysis for >70% of patients. It is unknown whether industry consolidation has affected patients' ability to choose among competing dialysis providers. We identified patients receiving in-center hemodialysis at the start of 2001 and 2011 from the national ESRD registry and ascertained dialysis facility ownership...
November 9, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27774730/hyperprolactinemia-in-end-stage-renal-disease-and-effects-of-frequent-hemodialysis
#4
Joan C Lo, Gerald J Beck, George A Kaysen, Christopher T Chan, Alan S Kliger, Michael V Rocco, Glenn M Chertow
Introduction End-stage renal disease is associated with elevations in circulating prolactin concentrations, but the association of prolactin concentrations with intermediate health outcomes and the effects of hemodialysis frequency on changes in serum prolactin have not been examined. Methods The FHN Daily and Nocturnal Dialysis Trials compared the effects of conventional thrice weekly hemodialysis with in-center daily hemodialysis (6 days/week) and nocturnal home hemodialysis (6 nights/week) over 12 months and obtained measures of health-related quality of life, self-reported physical function, mental health and cognition...
October 23, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27766736/re-evaluation-of-re-hospitalization-and-rehabilitation-in-renal-research
#5
Eugene Lin, Manjula Kurella Tamura, Maria E Montez-Rath, Glenn M Chertow
Introduction The use of administrative data to capture 30-day readmission rates in end-stage renal disease is challenging since Medicare combines claims from acute care, inpatient rehabilitation (IRF), and long-term care hospital stays into a single "Inpatient" file. For data prior to 2012, the United States Renal Data System does not contain the variables necessary to easily identify different facility types, making it likely that prior studies have inaccurately estimated 30-day readmission rates. Methods For this report, we developed two methods (a "simple method" and a "rehabilitation-adjusted method") to identify acute care, IRF, and long-term care hospital stays from United States Renal Data System claims data, and compared them to methods used in previously published reports...
October 20, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27751901/30-day-readmissions-after-an-acute-kidney-injury-hospitalization
#6
Samuel A Silver, Ziv Harel, Eric McArthur, Danielle M Nash, Rey Acedillo, Abhijat Kitchlu, Amit X Garg, Glenn M Chertow, Chaim M Bell, Ron Wald
BACKGROUND: The risk of hospital readmission in acute kidney injury survivors is not well understood. We estimated the proportion of acute kidney injury patients who were rehospitalized within 30 days and identified characteristics associated with hospital readmission. METHODS: We conducted a population-based study of patients who survived a hospitalization complicated by acute kidney injury from 2003-2013 in Ontario, Canada. The primary outcome was 30-day hospital readmission...
October 14, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27688297/estimating-the-risk-of-radiocontrast-associated-nephropathy
#7
Emilee Wilhelm-Leen, Maria E Montez-Rath, Glenn Chertow
Estimates of the incidence of radiocontrast-associated nephropathy vary widely and suffer from misclassification of the cause of AKI and confounding. Using the Nationwide Inpatient Sample, we created multiple estimates of the risk of radiocontrast-associated nephropathy among adult patients hospitalized in the United States in 2009. First, we stratified patients according to the presence or absence of 12 relatively common diagnoses associated with AKI and evaluated the rate of AKI between strata. Next, we created a logistic regression model, controlling for comorbidity and acuity of illness, to estimate the risk of AKI associated with radiocontrast administration within each stratum...
September 29, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27634733/contemporary-use-of-partial-nephrectomy-are-older-patients-with-impaired-kidney-function-being-left-behind
#8
John T Leppert, Harsha R Mittakanti, I-Chun Thomas, Remy W Lamberts, Geoffrey A Sonn, Benjamin I Chung, Eila C Skinner, Todd H Wagner, Glenn M Chertow, James D Brooks
OBJECTIVE: To assess whether patient factors, such as age and preoperative kidney function, were associated with receipt of partial nephrectomy in a national integrated healthcare system. MATERIALS AND METHODS: We identified patients treated with a radical or partial nephrectomy from 2002 to 2014 in the Veterans Health Administration. We examined associations among patient age, sex, race or ethnicity, multimorbidity, baseline kidney function, tumor characteristics, and receipt of partial nephrectomy...
September 12, 2016: Urology
https://www.readbyqxmd.com/read/27610059/sex-differences-in-obesity-dietary-habits-and-physical-activity-among-urban-middle-class-bangladeshis
#9
Juliann Saquib, Nazmus Saquib, Marcia L Stefanick, Masuma Akter Khanam, Shuchi Anand, Mahbubur Rahman, Glenn M Chertow, Michele Barry, Tahmeed Ahmed, Mark R Cullen
BACKGROUND: The sustained economic growth in Bangladesh during the previous decade has created a substantial middle-class population, who have adequate income to spend on food, clothing, and lifestyle management. Along with the improvements in living standards, has also come negative impact on health for the middle class. The study objective was to assess sex differences in obesity prevalence, diet, and physical activity among urban middle-class Bangladeshi. METHODS: In this cross-sectional study, conducted in 2012, we randomly selected 402 adults from Mohammedpur, Dhaka...
July 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27599628/introduction-of-biosimilar-therapeutics-into-nephrology-practice-in-the-united-states-report-of-a-scientific-workshop-sponsored-by-the-national-kidney-foundation
#10
Jay B Wish, Chaim Charytan, Glenn M Chertow, Kamyar Kalantar-Zadeh, Alan S Kliger, Robert J Rubin, Jerry Yee, Steven Fishbane
Biosimilars are biologic medicines highly similar to the reference product with no meaningful clinical differences in terms of safety, purity, and potency. All biologic medicines are produced by living cells, resulting in an inherent heterogeneity in their higher order structures and post-translational modifications. In 2010, the US Congress enacted legislation to streamline the approval process for biosimilars of products losing patent protection, with the goal of decreasing costs and improving patient access to therapeutically important but expensive biologic agents...
September 3, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27529699/declining-rates-of-inpatient-parathyroidectomy-for-primary-hyperparathyroidism-in-the-us
#11
Sun Moon Kim, Aimee D Shu, Jin Long, Maria E Montez-Rath, Mary B Leonard, Jeffrey A Norton, Glenn M Chertow
Parathyroidectomy is the only curative therapy for patients with primary hyperparathyroidism. However, the incidence, correlates and consequences of parathyroidectomy for primary hyperparathyroidism across the entire US population are unknown. We evaluated temporal trends in rates of inpatient parathyroidectomy for primary hyperparathyroidism, and associated in-hospital mortality, length of stay, and costs. We used the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS) from 2002-2011...
2016: PloS One
https://www.readbyqxmd.com/read/27521103/clinical-trials-of-intensive-versus-less-intensive-control-of-hypertension-hope-or-hype
#12
Christina M Wyatt, Glenn M Chertow
The recently published Heart Outcomes Prevention Evaluation trial (HOPE-3) demonstrated no benefit of lowering blood pressure with candesartan and hydrochlorothiazide in persons at intermediate cardiovascular risk and with adequate blood pressure control as determined by the enrolling physician. The results of Systolic Blood Pressure Intervention Trial (SPRINT) and HOPE-3 highlight the importance of considering differences in study design and patient population when interpreting the results of clinical trials...
September 2016: Kidney International
https://www.readbyqxmd.com/read/27513312/chronic-kidney-disease-classification-in-systolic-blood-pressure-intervention-trial-comparison-using-modification-of-diet-in-renal-disease-and-ckd-epidemiology-collaboration-definitions
#13
Michael V Rocco, Arlene Chapman, Glenn M Chertow, Debbie Cohen, Jing Chen, Jeffrey A Cutler, Matthew J Diamond, Barry I Freedman, Amret Hawfield, Eric Judd, Anthony A Killeen, Kent Kirchner, Cora E Lewis, Nicholas M Pajewski, Barry M Wall, Jerry Yee
BACKGROUND: Interventional trials have used either the Modification of Diet in Renal Disease (MDRD) or chronic kidney disease (CKD)-Epidemiology Collaboration (CKD-EPI) equation for determination of estimated glomerular filtration rate (eGFR) to define whether participants have stages 3-5 CKD. The equation used to calculate eGFR may influence the number and characteristics of participants designated as having CKD. METHODS: We examined the classification of CKD at baseline using both equations in the Systolic Blood Pressure Intervention Trial (SPRINT)...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27444566/metabolic-profiling-of-impaired-cognitive-function-in-patients-receiving-dialysis
#14
Manjula Kurella Tamura, Glenn M Chertow, Thomas A Depner, Allen R Nissenson, Brigitte Schiller, Ravindra L Mehta, Sai Liu, Tammy L Sirich
Retention of uremic metabolites is a proposed cause of cognitive impairment in patients with ESRD. We used metabolic profiling to identify and validate uremic metabolites associated with impairment in executive function in two cohorts of patients receiving maintenance dialysis. We performed metabolic profiling using liquid chromatography/mass spectrometry applied to predialysis plasma samples from a discovery cohort of 141 patients and an independent replication cohort of 180 patients participating in a trial of frequent hemodialysis...
December 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27355909/effects-of-physician-payment-reform-on-provision-of-home-dialysis
#15
Kevin F Erickson, Wolfgang C Winkelmayer, Glenn M Chertow, Jay Bhattacharya
OBJECTIVES: Patients with end-stage renal disease can receive dialysis at home or in-center. In 2004, CMS reformed physician payment for in-center hemodialysis care from a capitated to a tiered fee-for-service model, augmenting physician payment for frequent in-center visits. We evaluated whether payment reform influenced dialysis modality assignment. STUDY DESIGN: Cohort study of patients starting dialysis in the United States in the 3 years before and the 3 years after payment reform...
June 1, 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27346666/predialysis-volume-overload-and-patient-reported-sleep-duration-and-quality-in-patients-receiving-hemodialysis
#16
Adrian P Abreo, Lorien S Dalrymple, Glenn M Chertow, George A Kaysen, Charles A Herzog, Kirsten L Johansen
Introduction Previous studies of patients with end-stage renal disease have examined the role of fluid shifts on apnea-hypopnea episodes, but the association between volume overload and patient-reported sleep quality or duration has not been well-established. Methods We studied the association between predialysis bioimpedance spectroscopy-derived volume estimates and self-reported sleep quality and duration in 638 patients in the United States Renal Data System ACTIVE/ADIPOSE study receiving hemodialysis from 2009 to 2011...
June 27, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27276913/risk-prediction-to-inform-surveillance-of-chronic-kidney-disease-in-the-us-healthcare-safety-net-a-cohort-study
#17
Yuxiang Xie, Marlena Maziarz, Delphine S Tuot, Glenn M Chertow, Jonathan Himmelfarb, Yoshio N Hall
BACKGROUND: The capacity of electronic health record (EHR) data to guide targeted surveillance in chronic kidney disease (CKD) is unclear. We sought to leverage EHR data for predicting risk of progressing from CKD to end-stage renal disease (ESRD) to help inform surveillance of CKD among vulnerable patients from the healthcare safety-net. METHODS: We conducted a retrospective cohort study of adults (nā€‰=ā€‰28,779) with CKD who received care within 2 regional safety-net health systems during 1996-2009 in the Western United States...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/27269300/rates-and-outcomes-of-parathyroidectomy-for-secondary-hyperparathyroidism-in-the-united-states
#18
Sun Moon Kim, Jin Long, Maria E Montez-Rath, Mary B Leonard, Jeffrey A Norton, Glenn M Chertow
BACKGROUND AND OBJECTIVES: Secondary hyperparathyroidism is common among patients with ESRD. Although medical therapy for secondary hyperparathyroidism has changed dramatically over the last decade, rates of parathyroidectomy for secondary hyperparathyroidism across the United States population are unknown. We examined temporal trends in rates of parathyroidectomy, in-hospital mortality, length of hospital stay, and costs of hospitalization. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample, a representative national database on hospital stay regardless of age and payer in the United States, we identified parathyroidectomies for secondary hyperparathyroidism from 2002 to 2011...
July 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27209075/early-to-dialyze-healthy-and-wise
#19
EDITORIAL
Glenn M Chertow, Wolfgang C Winkelmayer
No abstract text is available yet for this article.
May 24, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27195814/intensive-vs-standard-blood-pressure-control-and-cardiovascular-disease-outcomes-in-adults-aged-%C3%A2-75-years-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Jeff D Williamson, Mark A Supiano, William B Applegate, Dan R Berlowitz, Ruth C Campbell, Glenn M Chertow, Larry J Fine, William E Haley, Amret T Hawfield, Joachim H Ix, Dalane W Kitzman, John B Kostis, Marie A Krousel-Wood, Lenore J Launer, Suzanne Oparil, Carlos J Rodriguez, Christianne L Roumie, Ronald I Shorr, Kaycee M Sink, Virginia G Wadley, Paul K Whelton, Jeffrey Whittle, Nancy F Woolard, Jackson T Wright, Nicholas M Pajewski
IMPORTANCE: The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain. OBJECTIVE: To evaluate the effects of intensive (<120 mm Hg) compared with standard (<140 mm Hg) SBP targets in persons aged 75 years or older with hypertension but without diabetes. DESIGN, SETTING, AND PARTICIPANTS: A multicenter, randomized clinical trial of patients aged 75 years or older who participated in the Systolic Blood Pressure Intervention Trial (SPRINT)...
June 28, 2016: JAMA: the Journal of the American Medical Association
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