keyword
https://read.qxmd.com/read/38521989/prediction-of-mortality-in-patients-with-secondary-pulmonary-embolism-based-on-primary-admission-indication-a-short-communication
#1
JOURNAL ARTICLE
Martin J Ryll, Toby N Weingarten, Juraj Sprung
We evaluated the prediction of mortality in patients admitted to the intensive care unit (ICU) who subsequently developed a pulmonary embolism (PE) (i.e., secondary PE) using three PE-specific scores, the Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), and modified sPESI (ICU-sPESI) and compared them to the gold standard for the assessment of ICU all-cause mortality, the Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV). All critical care admission indications were grouped into four major categories: post-operative, cardiovascular, infectious (sepsis), and other...
March 23, 2024: Biomol Biomed
https://read.qxmd.com/read/38485844/prediction-of-mortality-in-acute-pulmonary-embolism-in-cancer-associated-thrombosis-maupe-c-derivation-and-validation-of-a-multivariable-model
#2
JOURNAL ARTICLE
Mario Aramberri, Jesús González-Olmedo, Adrián García-Villa, Ane Villanueva, Cristina Castillo Maza, Susana García-Gutiérrez, Carmen Diaz-Pedroche
Optimal risk stratification of patients with cancer and pulmonary embolism (PE) remains unclear. We constructed a clinical prediction rule (CPR) named 'MAUPE-C' to identify patients with low 30 days mortality. The study retrospectively developed and internally validated a CPR for 30 days mortality in a cohort of patients with cancer and PE (both suspected and unsuspected). Candidate variables were chosen based on the EPIPHANY study, which categorized patients into 3 groups based on symptoms, signs, suspicion and patient setting at PE diagnosis...
March 14, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38462535/home-treatment-for-active-cancer-patients-with-low-risk-pulmonary-embolism%C3%A3-a-predetermined-companion-report-from-the-onco-pe-trial
#3
JOURNAL ARTICLE
Ryuki Chatani, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Wataru Shioyama, Tatsuhiro Shibata, Yuji Nishimoto, Yoshito Ogihara, Kosuke Doi, Maki Oi, Taro Shiga, Daisuke Sueta, Kitae Kim, Yasuhiro Tanabe, Norimichi Koitabashi, Takuma Takada, Satoshi Ikeda, Hitoshi Nakagawa, Takayuki Mitsuhashi, Masaaki Shoji, Jiro Sakamoto, Shinji Hisatake, Yutaka Ogino, Masashi Fujita, Naohiko Nakanishi, Tomohiro Dohke, Seiichi Hiramori, Ryuzo Nawada, Kazuhisa Kaneda, Kazunori Mushiake, Hiromi Yamamoto, Kazushige Kadota, Koh Ono, Takeshi Kimura
BACKGROUND: Patients with appropriately selected low-risk pulmonary embolism (PE) can be treated at home, although it has been controversial whether applies to patients with cancer, who are considered not to be at low risk.Methods and Results: The current predetermined companion report from the ONCO PE trial evaluated the 3-month clinical outcomes of patients with home treatment and those with in-hospital treatment. The ONCO PE trial was a multicenter, randomized clinical trial among 32 institutions in Japan investigating the optimal duration of rivaroxaban treatment in cancer-associated PE patients with a score of 1 using the simplified version of the Pulmonary Embolism Severity Index (sPESI)...
March 8, 2024: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/38441514/development-and-validation-of-a-natural-language-processing-model-to-identify-low-risk-pulmonary-embolism-in-real-time-to-facilitate-safe-outpatient-management
#4
JOURNAL ARTICLE
Krunal D Amin, Elizabeth Hope Weissler, William Ratliff, Alexander E Sullivan, Tara A Holder, Cathleen Bury, Samuel Francis, Brent Jason Theiling, Bradley Hintze, Michael Gao, Marshall Nichols, Suresh Balu, William Schuyler Jones, Mark Sendak
STUDY OBJECTIVE: This study aimed to (1) develop and validate a natural language processing model to identify the presence of pulmonary embolism (PE) based on real-time radiology reports and (2) identify low-risk PE patients based on previously validated risk stratification scores using variables extracted from the electronic health record at the time of diagnosis. The combination of these approaches yielded an natural language processing-based clinical decision support tool that can identify patients presenting to the emergency department (ED) with low-risk PE as candidates for outpatient management...
March 2, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38421722/validity-of-mortality-risk-prediction-scores-in-critically-ill-patients-with-secondary-pulmonary-embolism
#5
JOURNAL ARTICLE
Martin J Ryll, Toby N Weingarten, Darrel R Schroeder, Juraj Sprung
Herein, we assess the use of the Acute Physiology and Chronic Health Evaluation-IV (APACHE-IV) and pulmonary embolism (PE)-specific risk scores to predict mortality among intensive care unit (ICU) patients who developed secondary PE. This retrospective cohort study used information from 208 United States critical care units recorded in the eICU Collaborative Research Database during 2014 and 2015. We calculated APACHE-IV, Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), and ICU-sPESI scores and compared their predicting performance using the area under the receiver operating characteristic (AUROC) curve...
February 28, 2024: Biomol Biomed
https://read.qxmd.com/read/38350930/deep-learning-segmentation-of-peri-sinus-structures-from-structural-magnetic-resonance-imaging-validation-and-normative-ranges-across-the-adult-lifespan
#6
JOURNAL ARTICLE
Kilian Hett, Colin D McKnight, Melanie Leguizamon, Jennifer S Lindsey, Jarrod J Eisma, Jason Elenberger, Adam J Stark, Alexander K Song, Megan Aumann, Ciaran M Considine, Daniel O Claassen, Manus J Donahue
BACKGROUND: Peri-sinus structures such as arachnoid granulations (AG) and the parasagittal dural (PSD) space have gained much recent attention as sites of cerebral spinal fluid (CSF) egress and neuroimmune surveillance. Neurofluid circulation dysfunction may manifest as morphological changes in these structures, however, automated quantification of these structures is not possible and rather characterization often requires exogenous contrast agents and manual delineation. METHODS: We propose a deep learning architecture to automatically delineate the peri-sinus space (e...
February 13, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38350784/performance-of-the-simplified-pulmonary-embolism-severity-index-in-predicting-30-day-mortality-after-acute-pulmonary-embolism-validation-from-a-large-scale-cohort
#7
JOURNAL ARTICLE
Yu Zhang, Yinong Chen, Hong Chen, Chunling Dong, Xiaoyun Hu, Xiaomao Xu, Ling Zhu, Zhe Cheng, Dingyi Wang, Zhu Zhang, Wanmu Xie, Jun Wan, Peiran Yang, Shengfeng Wang, Chen Wang, Zhenguo Zhai
BACKGROUND: The performance of existing prognostic scores including the simplified Pulmonary Embolism Severity Index (sPESI) for short-term mortality of non-high-risk PE in Chinese population has not been widely validated. METHODS: Non-high-risk patients were included from the prospective cohort of the China pUlmonary Thromboembolism REgistry Study (CURES). The sPESI, RIETE, Geneva, modified FAST, and Bova score were validated. The discriminatory performance was measured by the area under the curve (AUC)...
February 12, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38308882/outpatient-management-of-cancer-associated-pulmonary-embolism-a-post-hoc-analysis-from-the-home-pe-trial
#8
JOURNAL ARTICLE
Sérine Chaibi, Pierre-Marie Roy, Armelle Arnoux Guénégou, Yohann Tran, Olivier Hugli, Andréa Penaloza, Francis Couturaud, Cécile Tromeur, Tali-Anne Szwebel, Gilles Pernod, Antoine Elias, Alexandre Ghuysen, Ygal Benhamou, Nicolas Falvo, Henry Juchet, Mathilde Nijkeuter, Ronne Mairuhu, Laura M Faber, Isabelle Mahé, Karine Montaclair, Benjamin Planquette, David Jimenez, Menno V Huisman, Federikus A Klok, Olivier Sanchez
INTRODUCTION: Cancer-related pulmonary embolism (PE) is associated with poor prognosis. Some decision rules identifying patients eligible for home treatment categorize cancer patients at high risk of complications, precluding home treatment. We sought to assess the effectiveness and the safety of outpatient management of patients with low-risk cancer-associated PE. METHODS: In the HOME-PE trial, hemodynamically stable patients with symptomatic PE were randomized to either triaging with Hestia criteria or sPESI score...
January 26, 2024: Thrombosis Research
https://read.qxmd.com/read/38290712/evaluation-of-four-validated-risk-scores-to-predict-outcomes-in-hispanic-patients-with-acute-pulmonary-embolism
#9
JOURNAL ARTICLE
Adrian Rojas Murguia, Fernando Segovia, Fatih Ayvali, Michael Brockman, Swathi Prakash, Vishwajeet Singh, Alok Kumar Dwivedi, Manu Rajachandran, Debabrata Mukherjee, Nils P Nickel
Risk stratification plays an essential role in the management of acute pulmonary embolism (PE). Several risk scores have been studied to support risk stratification and management. While ethnic differences in acute PE risk factors exist, current risk scores lack validation for Hispanic patients. Therefore, the present study retrospectively investigated the performance of the pulmonary embolism severity index (PESI), simplified PESI (sPESI), the European Society of Cardiology risk assessment (ESC), and the Bova score, to predict 30-day mortality in Hispanic patients presenting with an acute PE...
January 30, 2024: Angiology
https://read.qxmd.com/read/38226583/the-vulnerable-elders-survey-13-ves-13-scale-is-superior-to-spesi-in-predicting-3-month-post-discharge-mortality-in-elderly-survivors-of-acute-pulmonary-embolism
#10
JOURNAL ARTICLE
Anna M Imiela, Elżbieta Kozak-Szkopek, Monika Szymańska, Katarzyna Wdowiak, Olga Dzikowska-Diduch, Aleksandra Żuk-Łapan, Andrzej Pruszczyk, Izabela Bukalska, Karolina Niewczas, Michał Machowski, Aisha Ou-Pokrzewińska, Piotr Pruszczyk
INTRODUCTION: Acute pulmonary embolism (APE) is the most serious manifestation of venous thromboembolism. The Simplified Pulmonary Embolism Severity Index (sPESI) is employed for prediction of 30-day mortality in APE. The Vulnerable Elders Survey (VES-13) is used to identify participants at risk of health impairment. OBJECTIVES: To compare the VES-13 scale and sPESI in predicting the 3-month mortality in elderly patients hospitalized for APE. PATIENTS AND METHODS: All patients with APE were managed according to ESC guidelines and followed up for at least 3 months after discharge...
January 11, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38193449/serum-albumin-for-short-term-poor-prognosis-in-patients-with-acute-pulmonary-embolism-a-clinical-study-based-on-a-database
#11
JOURNAL ARTICLE
Jiayong Qiu, Yingying Hao, Shenshen Huang, Tongsheng Wang, Xuegai He, Wei Wang, Dan Du, Yimin Mao, Yadong Yuan
The relationship between serum albumin (ALB) and short-term prognosis in patients with acute pulmonary embolism (APE) remains unclear. We investigated the predictive value of ALB for short-term prognosis in APE patients using our hospital pulmonary embolism (PE) database (384 patients consecutively collected). Logistic regression analysis and nomograms were applied to construct the predictive model, and validation was assessed. A total of 340 APE patients were included, with a 30-day all-cause mortality rate of 8...
January 9, 2024: Angiology
https://read.qxmd.com/read/38133539/pulmonary-embolism-a-practical-approach-to-update-risk-stratification-and-treatment-decisions-based-on-the-guidelines
#12
REVIEW
María Barca-Hernando, Luis Jara-Palomares
INTRODUCTION: Pulmonary embolism (PE) is a prevalent condition with a substantial morbi-mortality worldwide. Proper risk stratification of PE is essential for identifying the most suitable therapeutic strategy and the optimal care setting for the patient. This process entails evaluating various factors, including symptoms, comorbidities, and right heart dysfunction. AREAS COVERED: This review assesses the tools and methods utilized to identify and stratify individuals based on the probability of developing deterioration or death related to PE...
December 22, 2023: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/38112742/a-multidisciplinary-pulmonary-embolism-response-team-pert-first-experience-from-a-single-center-in-germany
#13
JOURNAL ARTICLE
Ingo Sagoschen, Barbara Scibior, Ioannis T Farmakis, Karsten Keller, Dirk Graafen, Eva-Verena Griemert, Markus Vosseler, Hendrik Treede, Thomas Münzel, Maike Knorr, Tommaso Gori, Stavros Konstantinides, Lukas Hobohm
BACKGROUND: Over the last few years, the concept of multidisciplinary pulmonary embolism response teams (PERTs) has emerged to encounter the increasing variety and complexity in managing acute pulmonary embolism (PE). PURPOSE: To investigate PERT's composition and added clinical value in a university center in Germany. METHODS: Over 4 years (01/2019-11/2022), patients with confirmed PE were enrolled in a prospective single-center cohort study (PERT Mainz)...
December 19, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38045153/clinical-results-of-high-probability-ventilation-perfusion-scintigraphy-in-the-diagnosis-of-pulmonary-embolism
#14
JOURNAL ARTICLE
Emine Afsin, Hamdi Afsin
PURPOSE: While computed tomography pulmonary angiography plays an effective role in the diagnosis and prognosis of pulmonary embolism (PE), there are not enough studies regarding ventilation/perfusion (V/Q) scintigraphy. We aimed to evaluate the clinical outcomes of PE patients whose V/Q scintigraphy was reported as high probability for PE. METHOD: Demographic data, Simplified Pulmonary Embolism Severity Index (SPESI), radiological findings, V/Q scintigraphy and echocardiographic (ECHO) findings, laboratory data, treatment information and comorbidities of 43 patients whose V/Q scintigraphy was reported as high probability for PE between January 2020 and January 2023 was recorded...
November 2023: Heliyon
https://read.qxmd.com/read/38010031/machine-learning-for-predicting-hemodynamic-deterioration-of-patients-with-intermediate-risk-pulmonary-embolism-in-intensive-care-unit
#15
JOURNAL ARTICLE
Jiatang Xu, Zhensheng Hu, Jianhang Miao, Lin Cao, Zhenluan Tian, Chen Yao, Kai Huang
BACKGROUND: Intermediate-risk pulmonary embolism (PE) patients in the Intensive Care Unit (ICU) are at a higher risk of hemodynamic deterioration than those in the general ward. This study aims to construct a machine learning (ML) model to accurately identify the tendency for hemodynamic deterioration in ICU's patients with intermediate-risk PE. METHOD: A total of 704 intermediate-risk PE patients from the MIMIC-IV database were retrospectively collected. The primary outcome was defined as hemodynamic deterioration occurring within 30 days after admission to ICU...
November 16, 2023: Shock
https://read.qxmd.com/read/37964551/predicting-hospital-survival-in-patients-admitted-to-icu-with-pulmonary-embolism
#16
JOURNAL ARTICLE
Martin J Ryll, Aurelia Zodl, Toby N Weingarten, Alejandro A Rabinstein, David O Warner, Darrell R Schroeder, Juraj Sprung
OBJECTIVE: The Pulmonary Embolism Severity Index (PESI) and simplified PESI (sPESI) predict mortality for patients with PE. We compared PESI/sPESI to the Acute Physiology and Chronic Health Evaluation IV (APACHE-IV) in predicting mortality in patients with PE admitted to the intensive care unit (ICU). Additionally, we assessed the performance of a novel ICU-sPESI score created by adding three clinical variables associated with acuity of PE presentation (intubation, confusion [altered mental status], use of vasoactive infusions) to sPESI...
November 15, 2023: Journal of Intensive Care Medicine
https://read.qxmd.com/read/37932588/reduced-fibrin-clot-permeability-on-admission-and-elevated-e-selectin-at-3-months-as-novel-risk-factors-of-residual-pulmonary-vascular-obstruction-in-patients-with-acute-pulmonary-embolism
#17
JOURNAL ARTICLE
Konrad Stępień, Michał Ząbczyk, Magdalena Kopytek, Joanna Natorska, Jarosław Zalewski, Anetta Undas
BACKGROUND: Residual pulmonary vascular obstruction (RPVO) is common following pulmonary embolism (PE) but its association with fibrin clot properties is poorly understood. We investigated whether prothrombotic state and hypofibrinolysis markers can identify patients with RPVO. METHODS: In 79 normotensive noncancer patients (aged 56 ± 13.3 years) with acute PE, we determined fibrin clot permeability (Ks ), clot lysis time (CLT), endogenous thrombin potential (ETP), fibrinolysis proteins, oxidative stress markers, and E-selectin on admission before initiation of anticoagulant therapy, after 5-7 days, and 3 months of anticoagulation...
November 6, 2023: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/37922657/application-of-the-riete-score-to-identify-low-risk-patients-with-pulmonary-embolism-from-the-command-vte-registry
#18
JOURNAL ARTICLE
Yuta Tsujisaka, Yugo Yamashita, Takeshi Morimoto, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Yuji Nishimoto, Jiro Sakamoto, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Takao Kato, Koh Ono, Takeshi Kimura
BACKGROUND: The RIETE score could be specifically useful for identification of low-risk pulmonary embolism (PE) patients for home treatment. However, the external validation of the RIETE score has been limited. METHODS: The COMMAND VTE Registry is a multicenter registry enrolling consecutive patients with acute symptomatic venous thromboembolism (VTE). The current study population consisted of 1479 patients with acute PE, who were divided into 2 groups; RIETE scores of 0 (N = 260) and ≥ 1 (N = 1219)...
October 24, 2023: Thrombosis Research
https://read.qxmd.com/read/37743933/impact-of-obstructive-sleep-apnea-on-disease-severity-and-adverse-outcomes-in-patients-with-acute-pulmonary-embolism
#19
JOURNAL ARTICLE
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
PURPOSE: Acute pulmonary embolism (PE) poses a life-threatening risk with high mortality rates. While the coexistence of PE and obstructive sleep apnea (OSA) is gaining recognition, its influence on PE severity and prognosis remains uncertain. This study aims to investigate the associations between OSA and disease severity, as well as outcomes, in patients with acute PE. PATIENTS AND METHODS: We conducted a retrospective cohort study on patients diagnosed with acute PE who had undergone previous cardiorespiratory polygraphy...
2023: Nature and Science of Sleep
https://read.qxmd.com/read/37581357/what-is-the-real-incidence-of-right-ventricular-affection-in-patients-with-acute-pulmonary-embolism
#20
JOURNAL ARTICLE
Christos Ballas, Lampros Lakkas, Olga Kardakari, Athanasios Konstantinidis, Konstantinos Exarchos, Stavroula Tsiara, Konstantinos Kostikas, Katerina Κ Naka, Lampros K Michalis, Christos S Katsouras
BACKGROUND: Echocardiographic markers of right ventricular dysfunction or pressure overload (RVd/PO ) have been used in risk assessment of patients with acute pulmonary embolism (APE). Nevertheless, the role of echocardiography in these patients is incompletely determined. We evaluated the right ventricular function using 'non-conventional' markers of RVd/PO in patients with APE. METHODS: This was a prospective, single-arm, single-centre study. Consecutive adult patients hospitalised for APE were included...
August 15, 2023: Acta Cardiologica
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