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Florence L Chiang, Chih-Kai Hong, Chih-Hsun Chang, Cheng-Li Lin, I-Ming Jou, Wei-Ren Su
PURPOSE: To compare the biomechanical characteristics of the subpectoral Y-knot all-suture anchor fixation with those of the interference screw technique. METHODS: Sixteen fresh-frozen human cadaveric shoulders with a mean age of 67.6 ± 5.8 years (range, 52 to 74 years) were studied. The specimens were randomly grouped into 2 experimental biceps tenodesis groups (n = 8): Y-knot all-suture anchor or interference screw. The specimens were cyclically tested to failure by applying tensile forces parallel to the longitudinal axis of the humerus...
July 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
L-G Zhao, J-W Sun, Y Yang, X Ma, Y-Y Wang, Y-B Xiang
BACKGROUND/OBJECTIVES: Although fish consumption may have an influence on specific mortality of major chronic diseases, the relationship between fish consumption and all-cause mortality remains inconsistent. SUBJECTS/METHODS: We performed a systematic search of publications using PubMed and Web of science up to 31 December 2014. Summary relative risk (RR) for the highest versus lowest category of fish consumption on risk of all-cause mortality was calculated by using a random effects model...
February 2016: European Journal of Clinical Nutrition
H J E Kwon, E K Park, S Jia, H Liu, Y Lan, R Jiang
Tooth organogenesis depends on genetically programmed sequential and reciprocal inductive interactions between the dental epithelium and neural crest-derived mesenchyme. Previous studies showed that the Msx1 and Runx2 transcription factors are required for activation of odontogenic signals, including Bmp4 and Fgf3, in the early tooth mesenchyme to drive tooth morphogenesis through the bud-to-cap transition and that Runx2 acts downstream of Msx1 to activate Fgf3 expression. Recent studies identified Osr2 as a repressor of tooth development and showed that inactivation of Osr2 rescued molar tooth morphogenesis in the Msx1(-/-) mutant mice as well as in mice with neural crest-specific inactivation of Bmp4...
August 2015: Journal of Dental Research
Phuong T Y Dinh, Linhai Zhang, Hassan Mojtahedi, Charles R Brown, Axel A Elling
Root-knot nematodes (Meloidogyne spp.) are a significant problem in potato (Solanum tuberosum) production. There is no potato cultivar with Meloidogyne resistance, even though resistance genes have been identified in wild potato species and were introgressed into breeding lines. The objectives of this study were to generate stable transgenic potato lines in a cv. Russet Burbank background that carry an RNA interference (RNAi) transgene capable of silencing the 16D10 Meloidogyne effector gene, and test for resistance against some of the most important root-knot nematode species affecting potato, i...
March 2015: Journal of Nematology
Chiaho Hua, Thomas E Merchant, Xingyu Li, Yimei Li, Barry L Shulkin
UNLABELLED: In this study, we reported age-associated ranges of the regional cerebral (18)F-FDG uptake ratio in pediatric patients as a surrogate to normative data from healthy children. METHODS: (18)F-FDG PET scans of 132 children and adolescents (age, 1-20 y) with non-central nervous system-related diseases and normal-appearing tracer distributions in the brain were retrospectively analyzed. PET images of individual patients were warped to a 3-dimensional reference template...
April 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
J Portillo, Y Diao, R Scharein, J Arsuaga, M Vazquez
We here address two problems concerning the writhe of random polygons. First, we study the behavior of the mean writhe as a function length. Second, we study the variance of the writhe. Suppose that we are dealing with a set of random polygons with the same length and knot type, which could be the model of some circular DNA with the same topological property. In general, a simple way of detecting chirality of this knot type is to compute the mean writhe of the polygons; if the mean writhe is non-zero then the knot is chiral...
2011: Journal of Physics. A, Mathematical and Theoretical
M Asadollahi-Baboli, A Mani-Varnosfaderani
The main idea of this study was to find predictive quantitative structure-activity relationships (QSAR) for the therapeutic index of 68 thiazolidin-4-one analogs against Toxoplasma gondii. Multivariate adaptive regression spline (MARS) together with Monte-Carlo (MC) sampling was proposed as a reliable descriptor subset selection strategy. Basis functions and knot points are also determined for each selected descriptor using generalized cross validation after frequency analysis. Least squares-support vector regression (LS-SVR) with optimized hyper-parameters was employed as mapping tool due to its promising empirical performance...
April 5, 2015: European Journal of Pharmaceutical Sciences
Suolin Li, Meng Li, Kenneth K Y Wong, Lin Liu, Paul K H Tam
BACKGROUND: Many different laparoscopic techniques for pediatric inguinal hernia (PIH) have been developed, with a trend toward increasing use of extracorporeal knotting and decreasing use of working ports. Single-port laparoscopic percutaneous extraperitoneal closure is one of the most simple and reliable methods. We describe our modifications of laparoscopically assisted simple suturing obliteration (LASSO) using an epidural needle with preperitoneal hydrodissection. MATERIALS AND METHODS: Two hundred and seven patients with PIH were treated with single-port LASSO from February 2010 to July 2013...
December 2014: Journal of Pediatric Surgery
H Wang, Z Wang, L Huang, A Mitra, Y Yan
This study demonstrates for the first time that porous zeolite films with surface patterns such as knotted-rope web and wrinkled honeycomb can be obtained by convection-assisted dynamic self-assembly of zeolite nanoparticles. The study also shows that an appropriate dispersant and the presence of zeolite nanoparticles with a specific range of particle sizes in the colloidal suspension are critical for pattern formation. The patterned zeolite films have a well-defined bimodal pore size distribution (i.e., 0...
May 1, 2001: Langmuir: the ACS Journal of Surfaces and Colloids
Wei-Ren Su, Florence Y Ling, Chih-Kai Hong, Chih-Hsun Chang, Cheng-Li Lin, I-Ming Jou
UNLABELLED: There are several options for LHB tenodesis; yet, there is no standard of care. This technical note describes an extramedullary all-suture anchor technique for LHB tenodesis that is similar to the extramedullary cortical button technique. The LHB tenodesis is performed by using the Y-Knot (1.3-mm; ConMed Linvatec, Largo, FL).The biceps tenotomy is completed arthroscopically, and a standard subpectoral approach is used for the tenodesis. A reamer is first used to drill through the anterior cortex of the humerus; subsequently, a 1...
February 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Jiaming Liu, Pengfei Han, Ying Xiao, Jiani Liu, Y James Kang
A novel knot method in rats is reported that addresses several drawbacks in the current model of aortic constriction-induced heart hypertrophy. Using a rat model, we developed a two-step procedure that includes 1) measurement of individual aorta circumference using a surgical thread; and 2) constriction of the aorta using a thread with the desired length predefined by a knot at each end for a measurable reduction of the aortic circumference as referenced to the measurement in step 1. This knot approach produces a manageable gradient of aortic constriction in each rat, reaching a consistency among experimental animals that cannot be achieved by the traditional needle method...
October 1, 2014: American Journal of Physiology. Heart and Circulatory Physiology
Woei Bing Poon, Stephanie M C Fook-Chong, Grace Y L Ler, Zhi Wen Loh, Cheo Lian Yeo
INTRODUCTION: Both gestation and birth weight have significant impact on mortality and morbidity in newborn infants. Nomograms at birth allow classification of infants into small for gestational age (SGA) and large for gestational age (LGA) categories, for risk stratification and more intensive monitoring. To date, the growth charts for preterm newborn infants in Singapore are based on the Fenton growth charts, which are constructed based on combining data from various Western growth cohorts...
June 2014: Annals of the Academy of Medicine, Singapore
Angelina M Vera, Michael Russo, Adnan Mohsin, Shawn Tsuda
BACKGROUND: Laparoscopic skills training has evolved over recent years. However, conveying a mentor's directions using conventional methods, without realistic on-screen visual cues, can be difficult and confusing. To facilitate laparoscopic skill transference, an augmented reality telementoring (ART) platform was designed to overlay the instruments of a mentor onto the trainee's laparoscopic monitor. The aim of this study was to compare the effectiveness of this new teaching modality to traditional methods in novices performing an intracorporeal suturing task...
December 2014: Surgical Endoscopy
Robert A Haney, Nadia A Ayoub, Thomas H Clarke, Cheryl Y Hayashi, Jessica E Garb
BACKGROUND: Animal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries. Next-generation transcriptomics and proteomics provide unparalleled, but underexploited, capabilities for venom characterization. We combined multi-tissue RNA-Seq with mass spectrometry and bioinformatic analyses to determine venom gland specific transcripts and venom proteins from the Western black widow spider (Latrodectus hesperus) and investigated their evolution...
2014: BMC Genomics
B Newland, A Aied, A V Pinoncely, Y Zheng, T Zhao, H Zhang, R Niemeier, E Dowd, A Pandit, W Wang
The purpose of this study was to develop a platform transfection technology, for applications in the brain, which could transfect astrocytes without requiring cell specific functionalization and without the common cause of toxicity through high charge density. Here we show that a simple and scalable preparation technique can be used to produce a "knot" structured cationic polymer, where single growing chains can crosslink together via disulphide intramolecular crosslinks (internal cyclizations). This well-defined knot structure can thus "untie" under reducing conditions, showing a more favorable transfection profile for astrocytes compared to 25 kDa-PEI (48-fold), SuperFect® (39-fold) and Lipofectamine®2000 (18-fold) whilst maintaining neural cell viability at over 80% after four days of culture...
July 7, 2014: Nanoscale
Phuong T Y Dinh, Charles R Brown, Axel A Elling
Meloidogyne chitwoodi, a quarantine pathogen, is a significant problem in potato-producing areas worldwide. In spite of considerable genetic diversity in wild potato species, no commercial potato cultivars with resistance to M. chitwoodi are available. Nematode effector genes are essential for the molecular interactions between root-knot nematodes and their hosts. Stable transgenic lines of Arabidopsis and potato (Solanum tuberosum) with resistance against M. chitwoodi were developed. RNA interference (RNAi) construct pART27(16D10i-2) was introduced into Arabidopsis thaliana and potato to express double-stranded RNA complementary to the putative M...
October 2014: Phytopathology
Candice Y Lee, Jude S Sauer, Heather R Gorea, Angelo J Martellaro, Peter A Knight
OBJECTIVE: This study compared the strength, consistency, and speed of prosthetic attachment sutures secured with automated fasteners with those of manual knots using an ex vivo porcine mitral valve annuloplasty model. A novel miniature pressure transducer system was developed to quantify pressures between sutured prosthetic rings and underlying cardiac tissue. METHODS: Sixteen mitral annuloplasty rings were sewn into ex vivo pig hearts. Eight rings were secured with the COR-KNOT device; and eight rings, with hand-tied knots using a knot pusher...
March 2014: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
M Y Sachkova, A A Slavokhotova, E V Grishin, A A Vassilevski
Yellow sac spiders (Cheiracanthium punctorium, family Miturgidae) are unique in terms of venom composition, because, as we show here, two-domain toxins have replaced the usual one-domain peptides as the major constituents. We report the structure of the two-domain Che. punctorium toxins (CpTx), along with the corresponding cDNA and genomic DNA sequences. At least three groups of insecticidal CpTx were identified, each consisting of several members. Unlike many cone snail and snake toxins, accelerated evolution is not typical of cptx genes, which instead appear to be under the pressure of purifying selection...
August 2014: Insect Molecular Biology
Alba F C Torres, Chen Huang, Cheong-Meng Chong, Siu Wai Leung, Alvaro R B Prieto-da-Silva, Alexandre Havt, Yves P Quinet, Alice M C Martins, Simon M Y Lee, Gandhi Rádis-Baptista
BACKGROUND: Dinoponera quadriceps is a predatory giant ant that inhabits the Neotropical region and subdues its prey (insects) with stings that deliver a toxic cocktail of molecules. Human accidents occasionally occur and cause local pain and systemic symptoms. A comprehensive study of the D. quadriceps venom gland transcriptome is required to advance our knowledge about the toxin repertoire of the giant ant venom and to understand the physiopathological basis of Hymenoptera envenomation...
2014: PloS One
Swati R Yedke, Subhash Y Raut, C R Jangde
BACKGROUND: Success of surgery depends on wound closure and healing. Ancients had coated many suture materials from plant and animal origin. As the quest for natural nonabsorbable, monofilament surgical suture continues, horsehair has been taken for study, which is mentioned in ancient literature. OBJECTIVES: Aim of the study was to evaluate detail mechanical and biophysical properties of horsehair. MATERIALS AND METHODS: Physical properties, that are diameter, straight pull and knot pull tensile strength, bioburden, sterility tests were performed...
October 2013: Journal of Ayurveda and Integrative Medicine
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