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https://www.readbyqxmd.com/read/28654421/correction-traf2-regulates-tnf-and-nf-%C3%AE%C2%BAb-signalling-to-suppress-apoptosis-and-skin-inflammation-independently-of-sphingosine-kinase-1
#1
Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke
No abstract text is available yet for this article.
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28653852/chemical-warfare-agents-detoxification-properties-of-zirconium-metal-organic-frameworks-by-synergistic-incorporation-of-nucleophilic-and-basic-sites
#2
Rodrigo Gil San Millan, Elena Lopez-Maya, Morgan G Hall, Natalia M Padial, Gregory W Peterson, Jared B DeCoste, Luisa Marleny Rodriguez-Albelo, J Enrique Oltra, Elisa Barea, Jorge A R Navarro
The development of protective self-detoxifying materials is an important societal challenge to counteract risk of attacks employing highly toxic chemical warfare agents (CWAs). In this work, we have developed bi-functional zirconium metal-organic frameworks (MOFs) incorporating variable amounts of nucleophilic amino residues by means of formation of the mixed ligand [Zr6O4(OH)4(bdc)6(1-x)(bdc-NH2)6x] (UiO-66-xNH2) and [Zr6O4(OH)4(bpdc)6(1-x)(bpdc-(NH2)2)6x] (UiO-67-x(NH2)2) systems where bdc= benzene-1,4-dicarboxylate; bdc-NH2= benzene-2-amino-1,4-dicarboxylate; bpdc= 4,4'-biphenyldicarboxylate; bpdc-(NH2)2= 2,2´-diamino-4,4'-biphenyldicarboxylate and x= 0, 0...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28653099/meeting-report-of-the-6th-heidelberg-myeloma-workshop-current-status-and-developments-in-diagnosis-and-therapy-of-multiple-myeloma
#3
Maximilian Merz, Marc S Raab, Hartmut Goldschmidt, Jens Hillengass
PURPOSE: The 6th Heidelberg Myeloma Workshop was held on May 5th and 6th, 2017 in the lecture hall of the University Hospital Heidelberg. METHODS AND RESULTS: Main topics of the meeting were (1) biology and genomics of multiple myeloma, (2) diagnostics and prognostic factors, (3) role of immunotherapy in multiple myeloma, as well as (4) therapy of multiple myeloma-drugs and treatment strategies. CONCLUSION: The landscape for the treatment of newly diagnosed and relapsed disease has significantly changed since the last Heidelberg Myeloma Workshop in 2015...
June 26, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28652419/resveratrol-attenuates-nicotine-mediated-oxidative-injury-by-inducing-manganese-superoxide-dismutase-in-renal-proximal-tubule-cells
#4
Samuel Hall, Mehul Dixit, Istvan Arany
BACKGROUND/AIM: Nicotine (NIC) exposure - via smoking and the increasingly popular E-cigarettes- increases oxidative stress and hence, renal risk in smokers. Resveratrol (RES) may help ameliorate this risk by mounting anti-oxidant responses in the kidney. MATERIALS AND METHODS: Renal proximal tubule cells (NRK52E) were treated with vehicle or 20 μM RES prior to treatment with 200 μM NIC and generation of reactive oxygen species (ROS) as well as cell viability was determined...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652317/the-protein-phosphatase-4-complex-promotes-the-notch-pathway-and-wingless-transcription
#5
Eric T Hall, Tirthadipa Pradhan-Sundd, Faaria Samnani, Esther M Verheyen
The Wnt/Wingless (Wg) pathway controls cell fate specification, tissue differentiation and organ development across organisms. Using an in vivo RNAi screen to identify novel kinase and phosphatase regulators of the Wg pathway, we identified subunits of the serine threonine phosphatase Protein phosphatase 4 (PP4). Knockdown of the catalytic and the regulatory subunits of PP4 cause reductions in the Wg pathway targets Senseless and Distal-less. We find that PP4 regulates the Wg pathway by controlling Notch-driven wg transcription...
June 26, 2017: Biology Open
https://www.readbyqxmd.com/read/28652007/cytokines-affecting-cd4-t-regulatory-cells-in-transplant-tolerance-iii-interleukin-5-il-5-promotes-survival-of-alloantigen-specific-cd4-t-regulatory-cells
#6
Bruce M Hall, Karren M Plain, Giang T Tran, Nirupama D Verma, Catherine M Robinson, Masaru Nomura, Rochelle Boyd, Suzanne J Hodgkinson
CD4(+)T cells mediate antigen-specific allograft tolerance, but die in culture without activated lymphocyte derived cytokines. Supplementation of the media with cytokine rich supernatant, from ConA activated spleen cells, preserves the capacity of tolerant cells to transfer tolerance and suppress rejection. rIL-2 or rIL-4 alone are insufficient to maintain these cells, however. We observed that activation of naïve CD4(+)CD25(+)FOXP3(+)Treg with alloantigen and the Th2 cytokine rIL-4 induces them to express interleukin-5 specific receptor alpha (IL-5Rα) suggesting that IL-5, a Th2 cytokine that is produced later in the immune response may promote tolerance mediating Treg...
June 23, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28651249/administration-of-the-mitochondrial-permeability-transition-pore-inhibitor-tro40303-prior-to-primary-percutaneous-coronary-intervention-does-not-affect-the-levels-of-pro-inflammatory-cytokines-or-acute-phase-proteins
#7
Noreen Butt, Lena K Bache-Mathiesen, Jan Erik Nordrehaug, Vegard Tuseth, Peter Scott Munk, Vernon Bonarjee, Trygve Sundby Hall, Svend Eggert Jensen, Sigrun Halvorsen, Huseyin Firat, Dan Atar, Alf Inge Larsen
OBJECTIVES: In the MITOCARE study, reperfusion injury was not prevented after administration of the mitochondrial permeability transition pore (mPTP) opening inhibitor, TRO40303, in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The effects of TRO40303 on pro-inflammatory cytokines and acute-phase proteins were assessed. METHODS: STEMI patients (n = 163, mean age 62 years) with chest pain within 6 h before admission for pPCI were randomized to intravenous bolus of TRO40303 (n = 83) or placebo (n = 80) prior to reperfusion...
June 27, 2017: Cardiology
https://www.readbyqxmd.com/read/28650766/murine-mesenchymal-cells-that-express-elevated-levels-of-the-cdk-inhibitor-p16-ink4a-in-vivo-are-not-necessarily-senescent
#8
David Frescas, Brandon Hall, Evguenia Strom, Lauren P Virtuoso, Mahima Gupta, Anatoli S Gleiberman, Elena Rydkina, Vitaly Balan, Slavoljub Vujcic, Olga B Chernova, Andrei V Gudkov
Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchymal cells isolated from mice that are highly p16(INK4a)-positive are proficient in proliferation but lack other properties of cellular senescence. These data, along with earlier reports on p16(Ink4a)-positive macrophages, indicate that p16(Ink4a)-positive and senescent cell populations only partially intersect, therefore, extending the list of potential cellular targets for anti- aging therapies...
June 26, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28650359/outcomes-of-concurrent-operations-results-from-the-american-college-of-surgeons-national-surgical-quality-improvement-program
#9
Jason B Liu, Julia R Berian, Kristen A Ban, Yaoming Liu, Mark E Cohen, Peter Angelos, Jeffrey B Matthews, David B Hoyt, Bruce L Hall, Clifford Y Ko
OBJECTIVE: To determine whether concurrently performed operations are associated with an increased risk for adverse events. BACKGROUND: Concurrent operations occur when a surgeon is simultaneously responsible for critical portions of 2 or more operations. How this practice affects patient outcomes is unknown. METHODS: Using American College of Surgeons' National Surgical Quality Improvement Program data from 2014 to 2015, operations were considered concurrent if they overlapped by ≥60 minutes or in their entirety...
June 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28650148/mgzno-zno-two-dimensional-electron-gas-photodetectors-fabricated-by-rf-sputtering
#10
J D Hwang, C C Yang, C M Chu
MgZnO/ZnO two-dimensional electron gas (2DEG) structures with ZnO annealed at various temperatures (600-900 ºC) and photodetectors (PDs) with and without a 2DEG structure were fabricated using a radio-frequency magnetron sputtering system. It was found that the carrier concentration and mobility increase with the annealing temperature owing to the improved crystalline in ZnO; however, high-temperature (800 ºC or higher) annealing can degrade the crystalline of the ZnO layer. Hall measurements showed that compared with bulk ZnO, the sheet carrier concentration of the 2DEG sample increased from 1...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28649831/non-abelian-parton-fractional-quantum-hall-effect-in-multilayer-graphene
#11
Yinghai Wu, Tao Shi, Jainendra K Jain
The current proposals for producing non-Abelian anyons and Majorana particles, which are neither fermions nor bosons, are primarily based on the realization of topological superconductivity in two dimensions. We show theoretically that the unique Landau level structure of bilayer graphene provides a new possible avenue for achieving such exotic particles. Specifically, we demonstrate the feasibility of a ``parton" fractional quantum Hall (FQH) state, which supports non-Abelian particles without the usual topological superconductivity...
June 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28649616/palliative-care-for-parkinson-s-disease-suggestions-from-a-council-of-patient-and-carepartners
#12
Kirk Hall, Malenna Sumrall, Gil Thelen, Benzi M Kluger
In 2015, the Parkinson's Disease Foundation sponsored the first international meeting on Palliative Care and Parkinson's disease and the Patient Centered Outcomes Research Institute funded the first comparative effectiveness trial of palliative care for Parkinson's disease. A council of Parkinson's disease patients and carepartners was engaged to assist with both projects. This council wrote the following manuscript as an opinion piece addressed to the clinical and research community on how palliative care could be applied to people living with Parkinson's disease and their families...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28649403/inter-personal-diversity-and-temporal-dynamics-of-dental-tongue-and-salivary-microbiota-in-the-healthy-oral-cavity
#13
Michael W Hall, Natasha Singh, Kester F Ng, David K Lam, Michael B Goldberg, Howard C Tenenbaum, Josh D Neufeld, Robert G Beiko, Dilani B Senadheera
Oral microbes form a complex and dynamic biofilm community, which is subjected to daily host and environmental challenges. Dysbiosis of the oral biofilm is correlated with local and distal infections and postulating a baseline for the healthy core oral microbiota provides an opportunity to examine such shifts during the onset and recurrence of disease. Here we quantified the daily, weekly, and monthly variability of the oral microbiome by sequencing the largest oral microbiota time-series to date, covering multiple oral sites in ten healthy individuals...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28649193/repeated-low-intensity-blast-exposure-is-associated-with-damaged-endothelial-glycocalyx-and-downstream-behavioral-deficits
#14
Aaron A Hall, Mirian I Mendoza, Hanbing Zhou, Michael Shaughness, Eric Maudlin-Jeronimo, Richard M McCarron, Stephen T Ahlers
Current clinical research into mild traumatic brain injury (mTBI) has focused on white matter changes as identified by advanced MRI based imaging techniques. However, perivascular tau accumulation in the brains of individuals diagnosed with mTBI suggests that the vasculature plays a key role in the pathology. This study used a rat model to examine whether the endothelial glycocalyx, a layer of the vasculature responsible for sensing luminal shear forces, is damaged by exposure to repeated low intensity blast, and whether this layer is associated with observed behavioral deficits...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28648844/novel-functions-for-the-rna-binding-protein-etr-1-in-caenorhabditis-elegans-reproduction-and-engulfment-of-germline-apoptotic-cell-corpses
#15
Ruby Boateng, Ken C Q Nguyen, David H Hall, Andy Golden, Anna K Allen
RNA-binding proteins (RBPs) are essential regulators of gene expression that act through a variety of mechanisms to ensure the proper post-transcriptional regulation of their target RNAs. RBPs in multiple species have been identified as playing crucial roles during development and as having important functions in various adult organ systems, including the heart, nervous, muscle, and reproductive systems. ETR-1, a highly conserved ELAV-Type RNA-binding protein belonging to the CELF/Bruno protein family, has been previously reported to be involved in C...
June 22, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28648821/caveolae-protect-notochord-cells-against-catastrophic-mechanical-failure-during-development
#16
Ye-Wheen Lim, Harriet P Lo, Charles Ferguson, Nick Martel, Jean Giacomotto, Guillermo A Gomez, Alpha S Yap, Thomas E Hall, Robert G Parton
The embryonic notochord is a flexible structure present during development that serves as scaffold for formation of the vertebrate spine. This rod-like organ is thought to have evolved in non-vertebrate chordates to facilitate locomotion by providing a rigid but flexible midline structure against which the axial muscles can contract. This hydrostatic "skeleton" is exposed to a variety of mechanical forces during oscillation of the body. There is evidence that caveolae, submicroscopic cup-shaped plasma membrane pits, can buffer tension in cells that undergo high levels of mechanical stress...
June 14, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28648806/the-evolutionary-consequences-of-stepwise-infection-processes
#17
REVIEW
Matthew D Hall, Gilberto Bento, Dieter Ebert
Molecular and cellular studies reveal that the resistance of hosts to parasites and pathogens is a cascade-like process with multiple steps required to be passed for successful infection. By contrast, much of evolutionary reasoning is based on strongly simplified, one- or two-step infection processes with simple genetics or on resistance being a quantitative trait. Here we attempt a conceptual unification of these two perspectives with the aim of cross-fostering research and filling some of the gaps in our concepts of the ecology and evolution of disease...
June 22, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28647544/racial-and-ethnic-disparities-among-state-medicaid-programs-for-breast-cancer-screening
#18
Florence K Tangka, Sujha Subramanian, Lee Rivers Mobley, Sonja Hoover, Jiantong Wang, Ingrid J Hall, Simple D Singh
Breast cancer screening by mammography has been shown to reduce breast cancer morbidity and mortality. The use of mammography screening though varies by race, ethnicity, and, sociodemographic characteristics. Medicaid is an important source of insurance in the US for low-income beneficiaries, who are disproportionately members of racial or ethnic minorities, and who are less likely to be screened than women with higher socioeconomic statuses. We used 2006-2008 data from Medicaid claims and enrollment files to assess racial or ethnic and geographic disparities in the use of breast cancer screening among Medicaid-insured women at the state level...
June 21, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28647467/reliability-and-measurement-error-of-the-osteoarthritis-research-society-international-recommended-performance-based-tests-of-physical-function-in-people-with-hip-and-knee-osteoarthritis
#19
Fiona Dobson, Rana S Hinman, Michelle Hall, Charlotte J Marshall, Tim Sayer, Clinton Anderson, Nicolas Newcomb, Paul W Stratford, Kim L Bennell
OBJECTIVE: To estimate the reliability and measurement error of performance-based tests of physical function recommended by the Osteoarthritis Research Society International in people with hip and/or knee osteoarthritis. DESIGN: Prospective repeated measures between independent raters within a session and within-rater over a week interval. Relative reliability was estimated for 51 people with hip and/or knee osteoarthritis (mean age 64.5 years, SD 6.21 years; 47% females; 36 (70%) primary knee OA) on the 30s Chair Stand Test (30sCST), 40m Fast Paced Walk Test (40mFPWT), 11-Stair Climb Test (11-step SCT), Timed Up and Go (TUG), Six Minute Walk Test (6MWT), 10m Fast Paced Walk Test (10mFPWT) and 20s Stair Climb Test (20sSCT) using intra-class correlation coefficients (ICC)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28645199/do-neurobiological-understandings-of-smoking-influence-quitting-self-efficacy-or-treatment-intentions
#20
Kylie Morphett, Adrian Carter, Wayne Hall, Jayne Lucke, Brad Partridge, Coral Gartner
Introduction: Addiction is increasingly defined as a "brain disease" caused by changes to neurochemistry. While nicotine addiction has historically been excluded in the brain disease model of addiction (BDMA), it is beginning to be labelled a chronic brain disease. We investigated whether Australian smokers endorse brain-based explanations of smoking, and whether these beliefs are associated with quitting self-efficacy or treatment intentions. Method: Cross-sectional study of Australian smokers (N=1,538) who completed a survey measuring their agreement with statements on the brain's role in smoking...
June 22, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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