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Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold Stanek
The aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-borne encephalitis (TBE), and aseptic meningitis/meningoencephalitis other than TBE) - 25 samples per group - were analyzed...
April 20, 2018: Ticks and Tick-borne Diseases
Tanja Vollmer, Juergen Diekmann, Matthias Eberhardt, Cornelius Knabbe, Jens Dreier
Diagnosis of hepatitis E virus (HEV) is usually determined serologically by detection of the presence of immunoglobulin (Ig)M antibodies or rising anti-HEV IgG titers. However, serological assays have demonstrated a significant variation in their sensitivities and specificities. In this study, we present the systematic comparison of different immunological anti-HEV assays using complete seroconversion panels of 10 virologically confirmed HEV genotype 3 infected individuals. Assay sensitivities were further evaluated by testing serially diluted World Health Organization (WHO) reference reagent for hepatitis E virus antibody and one patient sample infected with HEV genotype 3...
August 22, 2016: Viruses
Marco Antônio Brasil, Fábio Lopes Rocha, Mário Eduardo Pereira, Marcelo P Fleck, Marco Antônio Bessa, Neury Botega, Luiz Alberto Hetem
No abstract text is available yet for this article.
October 2015: Trends in Psychiatry and Psychotherapy
Joanna Zajkowska, Natalia Lelental, Alina Kulakowska, Barbara Mroczko, Sławomir Pancewicz, Robert Bucki, Johannes Kornhuber, Piotr Lewczuk
Lyme neuroborreliosis (LNB) is an infectious disease of the nervous system caused by the tick-borne spirochete Borrelia burgdorferi. The presence of B. burgdorferi specific antibodies in cerebrospinal fluid (CSF), with evidence of intrathecal production, is the traditional diagnostic standard, although has limitations it such as low sensitivity in the very early phase. In the current study, 27 patients with possible neuroborreliosis suffered from clinically defined Bannwarth syndrome. The control group (CON) consisted of 6 patients...
November 2015: Immunology Letters
Sara Maria Teixeira Sgobin, Ana Luisa Marques Traballi, Neury José Botega, Otávio Rizi Coelho
CONTEXT AND OBJECTIVE: Knowledge of socioeconomic impact of attempted suicide may sensitize managers regarding prevention strategies. There are no published data on this in Brazil. The aim here was to describe the direct and indirect costs of care of hospitalized cases of attempted suicide and compare these with the costs of acute coronary syndrome cases. DESIGN AND SETTING: Cost-of-illness study at a public university hospital in Brazil. METHOD: The costs of care of 17 patients hospitalized due to attempted suicide were compared with those of 17 acute coronary syndrome cases at the same hospital, over the same period...
May 2015: São Paulo Medical Journal, Revista Paulista de Medicina
Alcinéia Donizeti Ferreira, Alcion Sponholz, Célia Mantovani, Antônio Pazin-Filho, Afonso Dinis Costa Passos, Neury José Botega, Cristina Marta Del-Ben
The objective of this study was to characterize admissions to an emergency hospital due to suicide attempts and verify outcomes in 2 years. Data were collected from medical records and were analyzed using descriptive statistics and logistic regression. The sample consisted of 412 patients (58.7% women; mean age = 32.6 years old, SD = 14.3). Self-poisoning was the most frequent method (84.0%), and they were diagnosed mainly as depressive (40.3%) and borderline personality disorders (19.1%). Previous suicide attempts and current psychiatric treatment were reported by, respectively, 32...
2016: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
Amilton Dos Santos, Maitê Cruvinel Oliveira, Tiago Dos Santos Andrade, Rosana Ramos de Freitas, Cláudio Eduardo Muller Banzato, Renata Cruz Soares de Azevedo, Neury José Botega
OBJECTIVE: To describe the sociodemographic and clinical profile of patients who underwent electroconvulsive therapy (ECT) at a university general hospital. METHOD: In this retrospective study, records from all patients undergoing ECT between January 1988 and January 2008 at the psychiatric unit of the general hospital of Universidade Estadual de Campinas (UNICAMP) were reviewed. Telephone contact was made with patients/relatives to collect follow-up data. RESULTS: A total of 200 charts were reviewed...
2013: Trends in Psychiatry and Psychotherapy
Wen-Chieh Wu, Chien-Wei Su, Jyh-Yuan Yang, Szu-Fong Lin, Jen-Yu Chen, Jaw-Ching Wu
Variant performance of immunoglobulin M (IgM) and immunoglobulin G (IgG) hepatitis E virus (HEV) assays may impact the diagnosis. The present study aimed to evaluate four different IgM/IgG assays for HEV infection for application in national surveillance in nonendemic areas. Sera from 300 patients that were stored in the Centers for Disease Control (CDC) of Taiwan for suspected acute HEV infection from 2004 to 2008, and 18 serum samples from acute cases of HEV infection in Taipei Veteran General Hospital were evaluated...
April 2014: Journal of Medical Virology
Flávia Silva Arbex Borim, Marilisa Berti de Azevedo Barros, Neury José Botega
This study analyzed common mental disorders in the elderly according to demographic and socioeconomic characteristics, health-related behavior, and disease history. This was a cross-sectional, population-based study with a cluster sample using data from a health survey conducted in Campinas, São Paulo State, Brazil, in 2008. SRQ-20 was used to evaluate common mental disorders. Adjusted prevalence ratios were estimated using multiple Poisson regression. Prevalence of common mental disorders was 29.7%, and higher rates were associated with female gender, age 80 years or older, lower income, not working, sedentary lifestyle, poor self-rated health, and greater number of chronic diseases...
July 2013: Cadernos de Saúde Pública
Letícia Marín-León, Helenice Bosco de Oliveira, Neury José Botega
OBJECTIVE: To describe suicide rates by county size in the five geopolitical areas of Brazil. METHODS: This was an ecological, descriptive study of suicide deaths in Brazil that occurred among the population 10 years of age and older in 2004-2010. Data were obtained from the National Mortality Information System of Brazil. Counties were defined by size as: very large (200,000+), large (< 200,000-100,000), medium (< 100,000-50,000), small (< 50,000-20,000), very small (< 20,000-10,000, and micro (< 10,000)...
November 2012: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
Carlos Filinto da Silva Cais, Isabel Ugarte da Silveira, Sabrina Stefanello, Neury José Botega
The objective of this study was to improve health professionals' knowledge and attitudes toward suicide prevention. A suicide prevention training of 18 hours duration was conducted with 270 health professionals, mainly primary care workers, who were routinely involved with patients at high risk for suicide. Questionnaires were used to assess changes in attitudes and knowledge. The score in the knowledge questionnaire, with 21 points as maximum value, increased from 8.9 to 13 points (p < .001, significance level of 95%)...
2011: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
Sabrina Stefanello, Letícia Marín-Léon, Paula Teixeira Fernandes, Li M Li, Neury José Botega
OBJECTIVE: To estimate the frequency of depression/anxiety and to establish the social, epilepsy and psychiatric characteristics in individuals with epilepsy. METHOD: A cross-sectional study was employed to evaluate 153 subjects with epilepsy who were identified in a previous community-based survey. First, a structured interview was conducted, followed by a psychiatric evaluation. Subjects with depression were compared to those without, and subjects with anxiety were compared to those without...
2011: Arquivos de Neuro-psiquiatria
José Manoel Bertolote, Carolina de Mello-Santos, Neury José Botega
OBJECTIVE: Guide the health professional to identify risk factors and forms of protection, together with handling such patient throughout a clinical interview within the emergency service context. METHOD: Selected literature revision so as to identify relevant and illustrative key cases. RESULTS: The clinical interview is the best method to evaluate the suicidal risk and has two different aims: 1) emotional support and creation of a bond; 2) collecting information...
October 2010: Revista Brasileira de Psiquiatria
Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Daniela Dantas Lima, Karla Cristina Gaspar, Viviane Franco da Silva, Neury José Botega
OBJECTIVE: To compare the results of 6-month follow-ups for hospitalized patients who were divided into two groups of low- and high-intensity treatments for smoking cessation and compared to the results of standard hospital treatment. METHODS: A total of 2414 patients were screened. Two hundred thirty-seven current smokers were randomly assigned to high-intensity intervention (HII; 30-min motivational interview plus seven routine telephone calls after hospital discharge) or to low-intensity intervention (LII; 15-min counseling about the benefits of quitting) and 80 comprised the usual care (UC) group...
November 2010: General Hospital Psychiatry
José M Bertolote, Alexandra Fleischmann, Diego De Leo, Michael R Phillips, Neury J Botega, Lakshmi Vijayakumar, Damani De Silva, Lourens Schlebusch, Van Tuong Nguyen, Merike Sisask, Jafar Bolhari, Danuta Wasserman
BACKGROUND: Attempted suicide is a strong risk factor for subsequent suicidal behaviors. Innovative strategies to deal with people who have attempted suicide are needed, particularly in resource-poor settings. AIMS: To evaluate a brief educational intervention and periodic follow-up contacts (BIC) for suicide attempters in five culturally different sites (Campinas, Brazil; Chennai, India; Colombo, Sri Lanka; Karaj, Islamic Republic of Iran; and Yuncheng, People's Republic of China) as part of the WHO Multisite Intervention Study on Suicidal Behaviors (SUPRE-MISS)...
2010: Crisis
Neury José Botega, Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Gabriela Nero Mitsuushi, Priscila Caroline Fanger, Daniela Dantas Lima, Karla Cristina Gaspar, Viviane Franco da Silva
OBJECTIVE: To identify the factors associated with suicide ideation among medically and surgically hospitalized patients. METHODS: A consecutive sample of 4328 individuals admitted to a general hospital completed a screening questionnaire comprised of demographic and clinical information, the Mini International Neuropsychiatric Interview item on current suicide ideation, the Hospital Anxiety and Depression Scale subscale for depression and the Alcohol use Disorder Identification Test...
July 2010: General Hospital Psychiatry
Neury José Botega, Gabriela Nero Mitsuushi, Renata Cruz Soares de Azevedo, Daniela Dantas Lima, Priscila Caroline Fanger, Marisa Lúcia Fabrício Mauro, Karla Cristina Gaspar, Viviane Franco da Silva
OBJECTIVE: To determine prevalence rates and identify patient characteristics associated with depression, alcohol use disorders and nicotine dependence among individuals admitted to a general teaching hospital. METHOD: Using the Hospital Anxiety and Depression Scale and Alcohol Use Disorder Identification Test, we assessed 4,352 consecutive medical and surgical patients admitted over a 13-month period. The patients were also asked to report their daily cigarette smoking habits during the last month...
September 2010: Revista Brasileira de Psiquiatria
Priscila Caroline Fanger, Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Daniela Dantas Lima, Karla Cristina Gaspar, Viviane Franco da Silva, Wagner Tadeu Jurevicius do Nascimento, Neury José Botega
OBJECTIVE: To determine prevalence rates of depression and suicidal behavior among cancer inpatients and factors associated with these conditions. METHODS: A total of 5357 patients consecutively admitted to a university hospital were assessed by means of the Hospital Anxiety and Depression Scale (HAD) and the suicide risk section of the Mini International Neuropsychiatric Interview (MINI). Univariate analyses adjusted for gender and age groups were performed with depression and suicide risk as dependent variables...
March 2010: Revista da Associação Médica Brasileira
Michael Mahler, Liesbeth Maes, Daniel Blockmans, Rene Westhovens, Xavier Bossuyt, Gabriela Riemekasten, Sandra Schneider, Falk Hiepe, Andreas Swart, Irmgard Gürtler, Karl Egerer, Margrit Fooke, Marvin J Fritzler
INTRODUCTION: Anti-centromere antibodies (ACA) are useful biomarkers in the diagnosis of systemic sclerosis (SSc). ACA are found in 20 to 40% of SSc patients and, albeit with lower prevalence, in patients with other systemic autoimmune rheumatic diseases. Historically, ACA were detected by indirect immunofluorescence (IIF) on HEp-2 cells and confirmed by immunoassays using recombinant CENP-B. The objective of this study was to evaluate a novel CENP-A peptide ELISA. METHODS: Sera collected from SSc patients (n=334) and various other diseases (n=619) and from healthy controls (n=175) were tested for anti-CENP-A antibodies by the novel CENP-A enzyme linked immunosorbent assay (ELISA)...
2010: Arthritis Research & Therapy
Neury José Botega, Letícia Marín-León, Helenice Bosco de Oliveira, Marilisa Berti de Azevedo Barros, Viviane Franco da Silva, Paulo Dalgalarrondo
This study aimed to estimate the lifetime prevalence rates for suicidal ideation, suicide plans, and attempted suicide, based on a cluster sample of 515 residents of Campinas, São Paulo State, Brazil. The Multisite Intervention Study on Suicidal Behavior interview was performed, and lifetime prevalence rates and 95% confidence intervals (95%CI) were calculated. Lifetime prevalence rates were 17.1% (95%CI: 12.9-21.2) for suicidal ideation, 4.8% (95%CI: 2.8-6.8) for suicide plans, and 2.8% (95%CI: 0.09-4.6) for attempted suicide...
December 2009: Cadernos de Saúde Pública
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