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irritable Bowel Syndrome Constipation

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https://www.readbyqxmd.com/read/29774051/alosetron-use-in-clinical-practice-significant-improvement-in-irritable-bowel-syndrome-symptoms-evaluated-using-the-us-food-and-drug-administration-composite-endpoint
#1
Brian E Lacy, Jean Paul Nicandro, Emil Chuang, David L Earnest
Background: Alosetron is approved to treat women with severe IBS and diarrhea (IBS-D) who have failed standard therapy. In our study, we aimed to evaluate alosetron efficacy using new US Food and Drug Administration (FDA) endpoints and utilization in clinical practice. Methods: This prospective, open-label, multicenter, observational 12-week study evaluated women with severe IBS-D enrolled in the alosetron prescribing program. The coprimary FDA endpoints were changes from baseline in stool consistency and abdominal pain severity...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29755994/therapeutic-effects-of-low-dose-bismuth-subcitrate-on-symptoms-and-health-related-quality-of-life-in-adult-patients-with-irritable-bowel-syndrome-a-clinical-trial
#2
Hamed Daghaghzadeh, Ardalan Memar, Yasaman Mohamadi, Nooshin Rezakhani, Parastoo Safazadeh, Sarina Aghaha, Payman Adibi
Objective: Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract that causes abdominal pain or discomfort and alters bowel with no organic abnormalities. Treatment options for IBS have increased in number in the past decade, and clinicians should not be limited to use only conventional treatments to cure it. This article is a placebo-controlled clinical trial to assess the therapeutic effects of low-dose bismuth subcitrate on symptoms and the health-related quality of life in adult patients with IBS...
January 2018: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29752611/comparison-of-electroacupuncture-and-mild-warm-moxibustion-on-brain-gut-function-in-patients-with-constipation-predominant-irritable-bowel-syndrome-a-randomized-controlled-trial
#3
Ji-Meng Zhao, Jin-Hua Lu, Xiao-Jun Yin, Lu-Yi Wu, Chun-Hui Bao, Xing-Kui Chen, Yue-Hua Chen, Wei-Jun Tang, Xiao-Ming Jin, Huan-Gan Wu, Yin Shi
OBJECTIVE: To compare the effects of electroacupuncture (EA) and mild-warm moxibustion (Mox) therapies for constipation-predominant irritable bowel syndrome (C-IBS) patients. METHODS: Sixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group (30 cases) and Mox group (30 cases). Both EA and Mox treatments were performed on bilateral Tianshu (ST 25) and Shangjuxu (ST 37) for 30 min each time, 6 times per week, for 4 consecutive weeks...
May 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29749705/fecal-clostridiales-distribution-and-short-chain-fatty-acids-reflect-bowel-habits-in-irritable-bowel-syndrome
#4
Giorgio Gargari, Valentina Taverniti, Claudio Gardana, Cesare Cremon, Filippo Canducci, Isabella Pagano, Maria Raffaella Barbaro, Lara Bellacosa, Anna Maria Castellazzi, Chiara Valsecchi, Sara Carlotta Tagliacarne, Massimo Bellini, Lorenzo Bertani, Dario Gambaccini, Santino Marchi, Michele Cicala, Bastianello Germanà, Elisabetta Dal Pont, Maurizio Vecchi, Cristina Ogliari, Walter Fiore, Vincenzo Stanghellini, Giovanni Barbara, Simone Guglielmetti
Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified according to bowel habits as IBS with constipation (IBS-C), with diarrhea (IBS-D), with alternating constipation and diarrhea (IBS-M), and unsubtyped (IBS-U). The mechanisms leading to the different IBS forms are mostly unknown. This study aims to evaluate whether specific fecal bacterial taxa and/or short-chain fatty acids (SCFAs) can be used to distinguish IBS subtypes and are relevant for explaining the clinical differences between IBS sub-categories...
May 11, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29742779/efficacy-and-tolerability-of-linaclotide-in-the-treatment-of-irritable-bowel-syndrome-with-constipation-in-a-real%C3%A2-world-setting-results-from-a-german-noninterventional-study
#5
Viola Andresen, Stephan Miehlke, Elmar Beck, Gwen Wiseman, Peter Layer
BACKGROUND:  Linaclotide is a minimally absorbed peptide guanylate cyclase-C agonist approved for the treatment of irritable bowel syndrome with constipation (IBS-C). This study assessed the efficacy and tolerability of linaclotide in IBS-C in routine clinical practice in Germany. METHODS:  This was a 52-week, noninterventional study of linaclotide in patients aged ≥ 18 years with moderate to severe IBS-C. Severity of abdominal pain and bloating and frequency of bowel movements were assessed over 5 study visits...
May 9, 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29737803/efficacy-of-actinidin-containing-kiwifruit-extract-zyactinase-on-constipation-a-randomised-double-blinded-placebo-controlled-clinical-trial
#6
Iona Weir, Quan Shu, Nengding Wei, Chengkai Wei, Yi Zhu
BACKGROUND AND OBJECTIVES: Zyactinase® is an extract of green kiwifruit, formulated into the consumer healthcare products marketed as Phloe® and Kivia, used to assist in the relief of the symptoms associated with a range of digestive system dysfunction, including constipation and Irritable Bowel Syndrome (IBS). METHODS AND STUDY DESIGN: A randomised, double-blind, placebo-controlled clinical trial was undertaken to determine the ef-fects of the kiwifruit extract on bowel movement, stool formation and IBS associated symptoms amongst a sub-ject group of generally healthy individuals experiencing a period of moderate constipation...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29709346/a-link-between-nutritional-and-growth-states-in-pediatric-patients-with-functional-gastrointestinal-disorders
#7
Katarzyna Pawłowska, Wioleta Umławska, Barbara Iwańczak
OBJECTIVE: To investigate nutritional status and growth status of pediatric patients with functional gastrointestinal disorders (FGIDs) and to examine the relationship between nutritional status and linear growth in these children. STUDY DESIGN: In total, 102 pediatric patients diagnosed with functional constipation (FC), irritable bowel syndrome (IBS), or functional abdominal pain (FAP) in years 2013-2015 were subjected to anthropometric measurements. Anthropometry comprised body height, leg and trunk lengths, body weight, mid-upper arm circumference, and 3 skinfold thicknesses...
April 27, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29698332/serum-proteomics-in-african-american-female-patients-with-irritable-bowel-syndrome-an-exploratory-study
#8
Kristen R Weaver, Gail D' Eramo Melkus, Jason Fletcher, Wendy A Henderson
BACKGROUND: Sex and subtype differences within patients with irritable bowel syndrome (IBS) complicate the understanding of disorder pathogenesis and hinder the design of efficacious, therapeutic interventions. OBJECTIVES: The aims of this study were to harness the power of shotgun proteomic analysis, identify circulating proteins that differentiate African American female patients with IBS from healthy controls (HC), and gain biological insight on symptomatology...
May 2018: Nursing Research
https://www.readbyqxmd.com/read/29694378/comparison-of-acupuncture-and-other-drugs-for-chronic-constipation-a-network-meta-analysis
#9
Lingping Zhu, Yunhui Ma, Xiaoyan Deng
The objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture and drugs in the treatment of chronic constipation. Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs for chronic constipation were comprehensively retrieved from electronic databases (such as PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, VIP Database and CBM) up to December 2017. Additional references were obtained from review articles. With quality evaluations and data extraction, a network meta-analysis (NMA) was performed using a random-effects model under a frequentist framework...
2018: PloS One
https://www.readbyqxmd.com/read/29687534/higher-prevalence-of-joint-hypermobility-in-constipation-predominant-irritable-bowel-syndrome
#10
A Zweig, V Schindler, A S Becker, A van Maren, D Pohl
BACKGROUND: Joint hypermobility syndrome (JHS) is characterized by excessive connective tissue laxity manifest as joint hypermobility (JH) together with musculoskeletal symptoms. Previous studies have shown an association between JH/JHS and gastrointestinal symptoms, including irritable bowel syndrome (IBS), although its association with specific IBS subtypes is incompletely understood. We aimed to determine the prevalence of JH according to the subtypes of IBS, in particular IBS-C and IBS-D...
April 23, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29685047/long-term-results-of-linaclotide-in-the-treatment-of-constipation-type-irritable-bowel-syndrome
#11
Fernando Geijo Martínez, Ana Sánchez Garrido, Héctor Marcos Prieto, Concepción Piñeiro Pérez, Ana Beatriz Prieto Bermejo, Alberto Álvarez Delgado, Antonio Velasco Guardado, Antonio Rodríguez Pérez
BACKGROUND: constipation-predominant irritable bowel syndrome (C-IBS) is a prevalent, complex and multifactorial disorder that represents a challenge in terms of diagnosis and therapeutic management. OBJECTIVE: to evaluate the effectiveness, safety and treatment satisfaction of linaclotide in C-IBS patients. METHODS: prospective, single-center and observational study conducted in patients diagnosed with C-IBS. The patients were treated with linaclotide (Constella®, Allergan Inc...
April 24, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29684865/the-effect-of-fecal-microbiota-transplantation-on-psychiatric-symptoms-among-patients-with-irritable-bowel-syndrome-functional-diarrhea-and-functional-constipation-an-open-label-observational-study
#12
Shunya Kurokawa, Taishiro Kishimoto, Shinta Mizuno, Tatsuhiro Masaoka, Makoto Naganuma, Kuo-Ching Liang, Momoko Kitazawa, Moeko Nakashima, Chie Shindo, Wataru Suda, Masahira Hattori, Takanori Kanai, Masaru Mimura
BACKGROUNDS: The intestinal microbiota is considered as a potential common underpinning pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and psychiatric disorders such as depression and anxiety. Fecal Microbiota Transplantation (FMT) has been reported to have therapeutic effects on diseases related to dysbiosis, but few studies have evaluated its effect on psychiatric symptoms. METHODS: We followed 17 patients with either Irritable Bowel Syndrome (IBS), Functional Diarrhea (FDr) or Functional Constipation (FC) who underwent FMT for the treatment of gastrointestinal symptoms and observation of psychiatric symptoms...
April 12, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29678362/bowel-symptoms-in-patients-that-receive-proton-pump-inhibitors-results-of-a-multicenter-survey-in-mexico
#13
M J Schmulson, A C Frati-Munari
INTRODUCTION: Proton pump inhibitors (PPIs) have been associated with small intestinal bacterial overgrowth (SIBO), which increases with prolonged PPI use, and SIBO has been associated with irritable bowel syndrome (IBS). OBJECTIVE: The aim of the present study was to study the prevalence of bowel symptoms in patients treated with PPIs in Mexico. METHODS: Gastroenterologists in 36 cities surveyed patients treated with PPIs, utilizing an ad hoc questionnaire to determine the presence of bowel symptoms and IBS...
April 17, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29626450/female-specific-association-between-variants-on-chromosome-9-and-self-reported-diagnosis-of-irritable-bowel-syndrome
#14
Ferdinando Bonfiglio, Tenghao Zheng, Koldo Garcia-Etxebarria, Fatemeh Hadizadeh, Luis Bujanda, Francesca Bresso, Lars Agreus, Anna Andreasson, Aldona Dlugosz, Greger Lindberg, Peter T Schmidt, Pontus Karling, Bodil Ohlsson, Magnus Simren, Susanna Walter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Piero Portincasa, Massimo Bellini, Giovanni Barbara, Anna Latiano, Matthias Hübenthal, Vincent Thijs, Mihai G Netea, Daisy Jonkers, Lin Chang, Emeran A Mayer, Mira M Wouters, Guy Boeckxstaens, Michael Camilleri, Andre Franke, Alexandra Zhernakova, Mauro D'Amato
BACKGROUND & AIMS: Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based cohort, which includes genotype and health data from 500,000 participants. METHODS: We studied 7,287,191 high-quality single-nucleotide polymorphisms in individuals who self-reported a doctor's diagnosis of IBS (cases; m=9576) compared to the remainder of the cohort (controls; n=336,499) (mean age of study subjects, 40-69 years)...
April 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29622940/plecanatide-trulance-for-chronic-idiopathic-constipation-and-irritable-bowel-syndrome-with-constipation
#15
Julia A Kamuda, Nissa Mazzola
Plecanatide (Trulance) for chronic idiopathic constipation and irritable bowel syndrome with constipation.
April 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29605985/lower-and-upper-gastrointestinal-symptoms-differ-between-individuals-with-irritable-bowel-syndrome-with-constipation-or-chronic-idiopathic-constipation
#16
Eric D Shah, Christopher V Almario, Brennan M R Spiegel, William D Chey
Background/Aims: We evaluated the distribution of lower and upper gastrointestinal (GI) symptoms among individuals with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in a nationwide survey. Methods: Individuals (≥ 18 years of age) were identified from a nationwide sample of > 70 000 United States adults. Participants completed the National Institutes of Health GI Patient Reported Outcomes Measurement Information System (NIH GI-PROMIS) questionnaire...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29565640/sigmoid-colon-mucosal-gene-expression-supports-alterations-of-neuronal-signaling-in-irritable-bowel-syndrome-with-constipation
#17
Elizabeth J Videlock, Swapna Mahurkar-Joshi, Jill M Hoffman, Dimitrios Iliopoulos, Charalabos Pothoulakis, Emeran A Mayer, Lin Chang
OBJECTIVE: Peripheral factors likely play a role in at least a subset of irritable bowel syndrome (IBS) patients. Few studies have investigated mucosal gene expression using an unbiased approach. Here, we performed mucosal gene profiling in a sex-balanced sample to identify relevant signaling pathways and gene networks and compare to publicly available profiling data from additional cohorts. DESIGN: 20 Rome III+ IBS patients (10 IBS with constipation (IBS-C), 10 IBS with diarrhea (IBS-D) 5 men/women each) and 10 age/sex-matched healthy controls (HCs) underwent sigmoidoscopy with biopsy for gene microarray analysis, including differential expression, weighted gene co-expression network analysis (WGCNA), gene set enrichment analysis and comparison with publicly available data...
March 22, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29563144/guanylate-cyclase-c-as-a-therapeutic-target-in-gastrointestinal-disorders
#18
REVIEW
Scott A Waldman, Michael Camilleri
Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent disorders of the GI tract and consume a significant proportion of healthcare resources. Recent studies have shown that membrane-bound guanylate cyclase-C (GC-C) receptors lining the GI tract may serve as novel therapeutic targets in the treatment of FGIDs and IBDs. GC-C receptor activation by its endogenous paracrine hormones uroguanylin and guanylin, and the resulting intracellular production of its downstream effector cyclic GMP, occurs in a pH-dependent manner and modulates key physiological functions...
March 21, 2018: Gut
https://www.readbyqxmd.com/read/29545635/efficacy-safety-and-tolerability-of-plecanatide-in-patients-with-irritable-bowel-syndrome-with-constipation-results-of-two-phase-3-randomized-clinical-trials
#19
Darren M Brenner, Ronald Fogel, Spencer D Dorn, Richard Krause, Paul Eng, Robert Kirshoff, Anhthu Nguyen, Robert A Crozier, Leslie Magnus, Patrick H Griffin
OBJECTIVES: Two identical, phase 3, randomized, double-blind, placebo-controlled trials evaluated the efficacy and safety of plecanatide in patients with irritable bowel syndrome with constipation (IBS-C). METHODS: Adults meeting Rome III criteria for IBS-C were randomized (1:1:1) to placebo or plecanatide (3 or 6 mg) for 12 weeks. The primary efficacy end point was the percentage of overall responders (patients reporting ≥30% reduction from baseline in worst abdominal pain plus an increase of ≥1 complete spontaneous bowel movement (CSBM)/week from baseline in the same week for ≥6 of 12 treatment weeks)...
March 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29528206/functional-gastrointestinal-disorders-functional-lower-gastrointestinal-disorders-in-adults
#20
Michael Malone, Abdul Waheed, Samiullah Samiullah
Functional lower gastrointestinal disorders include irritable bowel syndrome (IBS), functional constipation, functional fecal incontinence, and functional anorectal pain. These disorders are common and have significant medical and social effects. They also can be challenging to manage. Patients with mild symptoms may benefit from lifestyle modification. IBS is classified into two subtypes: diarrhea-predominant and constipation-predominant. Depending on the IBS subtype and its likely etiology, patients may benefit from treatment with antispasmodics, antidepressants, guanylate cyclase-C agonists, chloride channel activators, antidiarrheal agents, probiotics, and/or antibiotics...
March 2018: FP Essentials
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