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https://www.readbyqxmd.com/read/29675791/chemotherapy-treatment-is-associated-with-altered-pd-l1-expression-in-lung-cancer-patients
#1
Lívia Rojkó, Lilla Reiniger, Vanda Téglási, Katalin Fábián, Orsolya Pipek, Attila Vágvölgyi, László Agócs, János Fillinger, Zita Kajdácsi, József Tímár, Balázs Döme, Zoltán Szállási, Judit Moldvay
OBJECTIVES: While the predictive value of programmed cell death ligand-1 (PD-L1) protein expression for immune checkpoint inhibitor therapy of lung cancer has been extensively studied, the impact of standard platinum-based chemotherapy on PD-L1 or programmed cell death-1 (PD-1) expression is unknown. The aim of this study was to determine the changes in PD-L1 expression of tumor cells (TC) and immune cells (IC), in PD-1 expression of IC, and in the amount of stromal mononuclear cell infiltration after platinum-based chemotherapy in patients with lung cancer...
April 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29675058/foreign-body-removal-by-flexible-bronchoscopy-using-retrieval-basket-in-children
#2
Kyunghoon Kim, Hye Jin Lee, Eun Ae Yang, Hwan Soo Kim, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Jin Tack Kim
OBJECTIVES: Aspiration of foreign bodies into the tracheobronchial tree is a common accident in children. This study aimed to evaluate the safety and outcome of foreign body removal by flexible bronchoscopy using a retrieval basket in children. METHODS: This was a retrospective study of children treated for foreign bodies in the airway via flexible bronchoscopy using a retrieval basket at a tertiary hospital in Korea between February 2014 and October 2017. The medical records of the patients were retrospectively reviewed and analyzed...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674397/massive-haemoptysis-secondary-to-mycotic-pulmonary-artery-aneurysm-in-subacute-invasive-aspergillosis
#3
Shahbaz Piracha, Asad Mahmood, Noman Qayyum, Muhammad Badar Ganaie
A 68-year-old man, presented with 3 week history of infective symptoms and mild haemoptysis. Past medical history included severe emphysema and a chronic right upper lobe (RUL) cavity. He was discharged from follow-up a year ago in view of clinical and radiological stability; previous bronchoscopic examinations yielded no specific diagnosis. CT scan on admission confirmed complex cavitary consolidation of RUL. He developed massive haemoptysis requiring intubation and ventilation. CT pulmonary angiogram (CTPA) revealed 16 mm RUL pulmonary artery (PA) aneurysm which was successfully embolized...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29673076/suppressed-calcineurin-dependent-gene-expression-identifies-lung-allograft-recipients-at-increased-risk-of-infection
#4
John R Greenland, Tiffany Chong, Angelia S Wang, Emily Martinez, Pavan Shrestha, Jasleen Kukreja, Steven R Hays, Jeffrey A Golden, Jonathan P Singer, Qizhi Tang
Lung transplant immunosuppression regimens generally include the calcineurin inhibitor tacrolimus. We hypothesized that mean residual expression (MRE) of calcineurin-dependent genes assesses rejection and infection risk better than tacrolimus trough. We prospectively followed 44 lung allograft recipients 2 to 18 months post-transplant and measured changes in whole blood IL-2, interferon-γ, and GM-CSF gene expression following a tacrolimus dose. Post-transplant duration, immunosuppressive medication levels, and bronchoscopic rejection and infection assessments were compared with MRE using generalized-estimating equation-adjusted models...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29669351/bronchial-thermoplasty-in-severe-asthma-best-practice-recommendations-from-an-expert-panel
#5
Peter I Bonta, Pascal Chanez, Jouke T Annema, Pallav L Shah, Robert Niven
Bronchial thermoplasty (BT) is a bronchoscopic treatment for patients with severe asthma who remain symptomatic despite optimal medical therapy. In this "expert best practice" paper, the background and practical aspects of BT are highlighted. Randomized, controlled clinical trials have shown BT to be safe and effective in reducing severe exacerbations, improving quality of life, and decreasing emergency department visits. Five-year follow-up studies have provided evidence of the functional stability of BT-treated patients with persistence of a clinical benefit...
April 17, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29664761/initial-clinical-experience-with-a-flexible-peripheral-21-g-needle-device
#6
Alain Tremblay, Renelle Myers, Eve-Lea Beaudoin, Martina Bonifazi, Antoine Delage, Marc Fortin, Christopher A Hergott, Paul R MacEachern, Tawimas Shaipanich, Benjamin Shieh, Stefano Gasparini, Stephen Lam
BACKGROUND: Bronchoscopic techniques can be used to safely sample peripheral lung nodules (PLN), and transbronchial needle aspiration (TBNA) can further increase the diagnostic yield. Current needle devices not necessarily designed for this indication have limitations. We report our initial experience with a new flexible nitinol peripheral TBNA needle specifically designed for such sampling. METHODS: Retrospective case review describing the first clinical cases performed with a commercially available 21-G peripheral TBNA device in 4 centers...
April 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29661466/endobronchial-topical-amphotericin-b-instillation-for-pulmonary-chromomycosis-after-lung-transplantation-a-case-report
#7
H Mitomo, A Sakurada, Y Matsuda, H Notsuda, T Watanabe, H Oishi, H Niikawa, S Maeda, M Noda, T Sado, T Amemiya, Y Yoshida, T Kikuchi, K Kamei, Y Okada
We report a very rare case of pulmonary chromomycosis caused by Scedosporium prolificans that developed after lung transplantation and was successfully treated with endobronchial topical amphotericin B instillation. The subject was a woman in her 50s with a history of bilateral lobar lung transplantation from living donors for idiopathic pulmonary hypertension. Eight years after the lung transplantation, chest radiography X-ray and computed tomography showed an abnormal shadow in the right lung. Bronchoscopic findings showed obstruction by a fungal component at the laterobasal bronchus B9...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29660267/recovery-process-and-determinants-of-adverse-event-occurrence-in-bronchoscopic-procedures-performed-under-general-anesthesia
#8
Derya Özden Omaygenç, Nermin Ünal, Saadet İpek Edipoğlu, Tuğçe Barca Şeker, Mehmet Akif Özgül, Demet Turan, Cengiz Özdemir, İbrahim Oğuz Karaca, Erdoğan Çetinkaya
OBJECTIVE: Regarding the fact that rigid bronchoscopy is generally performed under general anesthesia and this patient subgroup is remarkably morbid, encountering procedure and/or anesthesia related complications are highly likely. Here, we aimed to assess factors influencing recovery and detect possible determinants of adverse event occurence during these operations performed in a tertiary referral centre. METHODS: 81 consecutive ASA I-IV patients were recruited for this investigation...
April 16, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29660253/airway-stenting-for-patients-with-airway-stenosis-due-to-small-cell-lung-cancer
#9
Masahide Oki, Hideo Saka
BACKGROUND: Airway stenting has been reported to be useful for patients with malignant airway stenosis as a bridge to tumor-specific therapy, such as chemotherapy and radiation therapy, as well as palliative therapy. However, its role in patients with small-cell lung cancer (SCLC), the most aggressive lung cancer subtype, is unclear. We investigated the efficacy of airway stenting for patients with airway stenosis resulting from SCLC. METHODS: All stenting procedures were performed using both rigid and flexible bronchoscopes under general anesthesia...
April 16, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29659422/bending-of-an-aspirated-pin-during-rigid-bronchoscopy-safeguards-and-pitfalls
#10
Abdelrahman A A Elsayed, Albaraa A Mansour, Ahmed A A Amin, Mohsen S M Ahmed
BACKGROUND: Pin aspiration is a common problem in Muslim countries, where many women wear veils (hijab). This condition is usually treated using either a rigid or a flexible bronchoscope, and yet occasionally requires surgical approach. Pin bending may be necessary to extract impacted pins during the therapeutic rigid bronchoscopy. MATERIALS AND METHODS: Medical records of patients who had pins extracted with a bending technique during the period from January 2012 to December 2016 in 1 institution were analyzed...
April 13, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29659421/air-splinting-maneuver-during-flexible-bronchoscopy-a-cross-sectional-study
#11
Rahul Magazine, Bharti Chogtu
BACKGROUND: Magazine's maneuver was developed for ease of insertion of the flexible bronchoscope, on encountering a closed lumen at the nasopharynx-oropharynx junction. The purposes of this study were to find the frequency of occurrence of such luminal closures and to compare the efficacy of Magazine's maneuver, with other variations of the maneuver, in improving visualization of the upper airway. MATERIALS AND METHODS: Patients aged 18 years and above who were undergoing flexible bronchoscopy were included, and their demographic and clinical data were noted...
April 13, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29658455/-efficacy-of-early-treatment-via-fiber-bronchoscope-in-children-with-mycoplasma-pneumoniae-pneumonia-complicated-by-airway-mucus-obstruction
#12
Li-Jie Cao, Jian-Hua Liu, Jin-Feng Shuai, Bo Niu, Su-Kun Lu, Kun-Ling Huang
OBJECTIVE: To study the efficacy of early treatment via fiber bronchoscope in children with Mycoplasma pneumoniae pneumonia (MPP) complicated by airway mucus obstruction. METHODS: According to the time from admission to the treatment via fiber bronchoscope, the children with MPP who were found to have airway mucus obstruction under a fiber bronchoscope were randomly divided into early intervention group (≤3 days; n=40) and late intervention group (>3 days; n=56)...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29657376/smoke-inhalation-injury-etiopathogenesis-diagnosis-and-management
#13
REVIEW
Kapil Gupta, Mayank Mehrotra, Parul Kumar, Anoop Raj Gogia, Arun Prasad, Joseph Arnold Fisher
Smoke inhalation injury is a major determinant of morbidity and mortality in fire victims. It is a complex multifaceted injury affecting initially the airway; however, in short time, it can become a complex life-threatening systemic disease affecting every organ in the body. In this review, we provide a summary of the underlying pathophysiology of organ dysfunction and provide an up-to-date survey of the various critical care modalities that have been found beneficial in caring for these patients. Major pathophysiological change is development of edema in the respiratory tract...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29657064/-selective-left-mainstem-bronchial-intubation-in-the-neonatal-intensive-care-unit
#14
Anthony M H Ho, Michael P Flavin, Melinda L Fleming, Glenio Bitencourt Mizubuti
BACKGROUND: Selective neonatal left mainstem bronchial intubation to treat right lung disease is typically achieved with elaborate maneuvers, instrumentation and devices. This is often attributed to bronchial geometry which favors right mainstem entry of an endotracheal tube deliberately advanced beyond the carina. CASE SUMMARY: A neonate with severe bullous emphysema affecting the right lung required urgent non-ventilation of that lung. We achieved left mainstem bronchial intubation by turning the endotracheal tube 180° such that the Murphy's eye faced the left instead of the right, and simulated a left-handed intubation by slightly orientating the endotracheal tube such that its concavity faced the left instead of the right as in a conventional right-handed intubation...
April 12, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29652684/biphasic-cuirass-ventilation-during-anesthesia-for-tracheobronchial-stent-insertion-or-removal-by-a-rigid-bronchoscope-a-case-report
#15
Hideaki Mori, Atsuko Shono, Ritsuko Hirade, Tetsuro Nikai, Yoji Saito
Airway management and ventilation during a tracheobronchial stenting procedure are challenging given that mandatory positive pressure ventilation cannot be fully achieved while using a rigid bronchoscope due to leakage from the scope tip. Biphasic cuirass ventilation is a negative pressure ventilation method using an external cuirass fitted to the anterior chest, which could assist in spontaneous breathing and ventilation support. We report 3 successful anesthesia cases in which we could maintain adequate ventilation and oxygenation, supported by biphasic cuirass ventilation, in patients undergoing tracheobronchial stent placement or removal procedures using rigid bronchoscopy...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29652241/bacterial-burden-in-critically-injured-ventilated-patients-does-not-correlate-with-progression-to-pneumonia
#16
Bradley M Dennis, Richard D Betzold, Daryl Patton, Herbert A Hopper, Judith Jenkins, Chris Fonnesbeck, Wonder Drake, Addison K May
BACKGROUND: Ventilator-associated pneumonia (VAP) is common in critically injured patients. The pathogenesis of VAP is not completely understood. We hypothesized that mechanically ventilated trauma patients who develop pneumonia have a progressive increase in pathogen burden over the course of ventilation until a threshold for symptomatic pneumonia is reached, leading to clinical suspicion of VAP. METHODS: Critically injured adults ventilated for more than two successive days were enrolled...
March 13, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29648882/endobronchial-mucormycosis-successfully-treated-with-flexible-bronchoscopic-cryotherapy
#17
Yeong Hun Choe, Yong Chul Lee, So Ri Kim
No abstract text is available yet for this article.
April 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29627058/nonoperative-endoscopic-management-of-benign-tracheobronchial-disorders
#18
REVIEW
Cameron D Wright
Modern thoracic surgery requires knowledge and skill in advanced bronchoscopic techniques. Rigid bronchoscopy remains a workhorse for the management of central airway obstruction. Dilation of tracheal strictures is now much simpler with the advent of the balloon dilator, which can be passed through a therapeutic bronchoscope. Numerous adjuncts, such as laser, argon beam coagulation, electrocautery, and cryotherapy, can be used to improve airway patency. There are now numerous stenting options for strictures that require stenting to maintain airway patency...
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29627056/airway-management-following-tracheal-surgery
#19
REVIEW
Thomas R J Todd
The ability to remove longer segments of airway and to extend resections into the larynx proper has managed to create novel situations that will require attention to postoperative management. This article deals with prophylactic measures to prevent the requirement of assisted ventilation. It, however, also emphasizes various bronchoscopic and intubation techniques, which if required, will help to avoid trauma to the airway anastomosis. In addition, a variety of ventilator modalities are discussed that were developed by the author over many years at the Toronto General Hospital...
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29621098/comparison-of-the-efficacy-and-efficiency-of-the-use-of-virtual-reality-simulation-with-high-fidelity-mannequins-for-simulation-based-training-of-fiberoptic-bronchoscope-manipulation
#20
Bailin Jiang, Hui Ju, Ying Zhao, Lan Yao, Yi Feng
INTRODUCTION: This study compared the efficacy and efficiency of virtual reality simulation (VRS) with high-fidelity mannequin in the simulation-based training of fiberoptic bronchoscope manipulation in novices. METHODS: Forty-six anesthesia residents with no experience in fiberoptic intubation were divided into two groups: VRS (group VRS) and mannequin (group M). After a standard didactic teaching session, group VRS trained 25 times on VRS, whereas group M performed the same process on a mannequin...
April 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
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