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https://www.readbyqxmd.com/read/29348647/the-contribution-of-predators-and-scavengers-to-human-well-being
#1
REVIEW
Christopher J O'Bryan, Alexander R Braczkowski, Hawthorne L Beyer, Neil H Carter, James E M Watson, Eve McDonald-Madden
Predators and scavengers are frequently persecuted for their negative effects on property, livestock and human life. Research has shown that these species play important regulatory roles in intact ecosystems including regulating herbivore and mesopredator populations that in turn affect floral, soil and hydrological systems. Yet predators and scavengers receive surprisingly little recognition for their benefits to humans in the landscapes they share. We review these benefits, highlighting the most recent studies that have documented their positive effects across a range of environments...
January 18, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29337204/the-positive-impacts-of-real-world-data-on-the-challenges-facing-the-evolution-of-biopharma
#2
REVIEW
John Wise, Angeli Möller, David Christie, Dipak Kalra, Elia Brodsky, Evelina Georgieva, Greg Jones, Ian Smith, Lars Greiffenberg, Marie McCarthy, Michael Arend, Olivier Luttringer, Sebastian Kloss, Steve Arlington
Demand for healthcare services is unprecedented. Society is struggling to afford the cost. Pricing of biopharmaceutical products is under scrutiny, especially by payers and Health Technology Assessment agencies. As we discuss here, rapidly advancing technologies, such Real-World Data (RWD), are being utilized to increase understanding of disease. RWD, when captured and analyzed, produces the Real-World Evidence (RWE) that underpins the economic case for innovative medicines. Furthermore, RWD can inform the understanding of disease, help identify new therapeutic intervention points, and improve the efficiency of research and development (R&D), especially clinical trials...
January 11, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29326187/pilot-study-protocol-to-inform-a-future-longitudinal-study-of-ageing-using-linked-administrative-data-healthy-ageing-in-scotland-hagis
#3
Elaine Douglas, Alasdair Rutherford, David Bell
INTRODUCTION: Population ageing is a welcome testament to improvements in the social, economic and health circumstances over the life course. However, these successes necessitate that we understand more about the pathways of ageing to plan and cost our health and social care services, to support our ageing population to live healthier for longer and to make adequate provisions for retirement. Longitudinal studies of ageing facilitate such understanding in many countries around the world...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29318985/a-randomised-controlled-trial-and-economic-evaluation-of-intraoperative-cell-salvage-during-caesarean-section-in-women-at-risk-of-haemorrhage-the-salvo-cell-salvage-in-obstetrics-trial
#4
Khalid S Khan, Philip Moore, Matthew Wilson, Richard Hooper, Shubha Allard, Ian Wrench, Tracy Roberts, Carol McLoughlin, Lee Beresford, James Geoghegan, Jane Daniels, Sue Catling, Vicki A Clark, Paul Ayuk, Stephen Robson, Fang Gao-Smith, Matthew Hogg, Louise Jackson, Doris Lanz, Julie Dodds
BACKGROUND: Caesarean section is associated with blood loss and maternal morbidity. Excessive blood loss requires transfusion of donor (allogeneic) blood, which is a finite resource. Cell salvage returns blood lost during surgery to the mother. It may avoid the need for donor blood transfusion, but reliable evidence of its effects is lacking. OBJECTIVES: To determine if routine use of cell salvage during caesarean section in mothers at risk of haemorrhage reduces the rates of blood transfusion and postpartum maternal morbidity, and is cost-effective, in comparison with standard practice without routine salvage use...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29314658/comparative-assessment-of-five-trials-of-universal-hiv-testing-and-treatment-in-sub-saharan-africa
#5
REVIEW
Delphine Perriat, Laura Balzer, Richard Hayes, Shahin Lockman, Fiona Walsh, Helen Ayles, Sian Floyd, Diane Havlir, Moses Kamya, Refeletswe Lebelonyane, Lisa A Mills, Velephi Okello, Maya Petersen, Deenan Pillay, Kalpana Sabapathy, Kathleen Wirth, Joanna Orne-Gliemann, François Dabis
DESIGN: Universal voluntary HIV counselling and testing followed by prompt initiation of antiretroviral therapy (ART) for all those diagnosed HIV-infected (universal test and treat, UTT) is now a global health standard. However, its population-level impact, feasibility and cost remain unknown. Five community-based trials have been implemented in sub-Saharan Africa to measure the effects of various UTT strategies at population level: BCPP/YaTsie in Botswana, MaxART in Swaziland, HPTN 071 (PopART) in South Africa and Zambia, SEARCH in Uganda and Kenya and ANRS 12249 TasP in South Africa...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29314035/economic-evaluation-of-floseal-compared-to-nasal-packing-for-the-management-of-anterior-epistaxis
#6
Andre Le, Kednapa Thavorn, Andrea Lasso, Shaun J Kilty
OBJECTIVES/HYPOTHESIS: To evaluate the cost-effectiveness of Floseal, a topically applied hemostatic agent, and nasal packing for the management of epistaxis in Canada. STUDY DESIGN: Outcomes research, a cost-utility analysis. METHODS: We developed a Markov model to compare the costs and health outcomes of Floseal with nasal packing over a lifetime horizon from the perspective of a publicly funded healthcare system. A cycle length of 1 year was used...
January 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29301745/the-economic-burden-of-cancer-care-in-canada-a-population-based-cost-study
#7
Claire de Oliveira, Sharada Weir, Jagadish Rangrej, Murray D Krahn, Nicole Mittmann, Jeffrey S Hoch, Kelvin K W Chan, Stuart Peacock
BACKGROUND: Resource and cost issues are a growing concern in health care. Thus, it is important to have an accurate estimate of the economic burden of care. Previous work has estimated the economic burden of cancer care for Canada; however, there is some concern this estimate is too low. The objective of this analysis was to provide a comprehensive revised estimate of this burden. METHODS: We used a case-control prevalence-based approach to estimate direct annual cancer costs from 2005 to 2012...
January 4, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29298736/multiple-frequency-bioimpedance-devices-for-fluid-management-in-people-with-chronic-kidney-disease-receiving-dialysis-a-systematic-review-and-economic-evaluation
#8
Graham Scotland, Moira Cruickshank, Elisabet Jacobsen, David Cooper, Cynthia Fraser, Michal Shimonovich, Angharad Marks, Miriam Brazzelli
BACKGROUND: Chronic kidney disease (CKD) is a long-term condition requiring treatment such as conservative management, kidney transplantation or dialysis. To optimise the volume of fluid removed during dialysis (to avoid underhydration or overhydration), people are assigned a 'target weight', which is commonly assessed using clinical methods, such as weight gain between dialysis sessions, pre- and post-dialysis blood pressure and patient-reported symptoms. However, these methods are not precise, and measurement devices based on bioimpedance technology are increasingly used in dialysis centres...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29298322/economic-evaluation-of-interventions-designed-to-reduce-clostridium-difficile-infection
#9
David Brain, Laith Yakob, Adrian Barnett, Thomas Riley, Archie Clements, Kate Halton, Nicholas Graves
INTRODUCTION: Healthcare decision-makers are increasingly expected to balance increasing demand for health services with a finite budget. The role of economic evaluation in healthcare is increasing and this research provides decision-makers with new information about the management of Clostridium difficile infection, from an economic perspective. METHODS: A model-based economic evaluation was undertaken to identify the most cost-effective healthcare intervention relating to the reduction of Clostridium difficile transmission...
2018: PloS One
https://www.readbyqxmd.com/read/29290394/the-impact-of-the-financial-crisis-and-austerity-policies-on-the-service-quality-of-public-hospitals-in-greece
#10
Ioanna Keramidou, Loukas Triantafyllopoulos
The influence of the financial crisis on the efficiency of Greek public hospitals has been widely debated. Despite this increasing interest in such research, the question of to what extent the recent reforms in the Greek National health care system were effective in establishing a health care structure and process that provide better results for patients has yet to be fully investigated. As a step in this direction, the paper focuses on patient's experience with public hospital care quality before and during the economic crisis...
December 24, 2017: Health Policy
https://www.readbyqxmd.com/read/29284715/pharmacy-diabetes-screening-trial-protocol-for-a-pragmatic-cluster-randomised-controlled-trial-to-compare-three-screening-methods-for-undiagnosed-type-2-diabetes-in-australian-community-pharmacy
#11
Ines Krass, Rob Carter, Bernadette Mitchell, Mohammadreza Mohebbi, Sophy T F Shih, Peta Trinder, Vincent L Versace, Frances Wilson, Kevin Mc Namara
INTRODUCTION: With the rising prevalence of type 2 diabetes in Australia, screening and earlier diagnosis is needed to provide opportunities to intervene with evidence-based lifestyle and treatment options to reduce the individual, social and economic impact of the disease. The objectives of the Pharmacy Diabetes Screening Trial are to compare the clinical effectiveness and cost-effectiveness of three screening models for type 2 diabetes in a previously undiagnosed population. METHODS AND ANALYSIS: The Pharmacy Diabetes Screening Trial is a pragmatic cluster randomised controlled trial to be conducted in 363 community pharmacies across metropolitan, regional and remote areas of Australia, randomly allocated by geographical clusters to one of three groups, each with 121 pharmacies and 10 304 screening participants...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29284285/barriers-to-contraceptive-careseeking-the-experience-of-eritrean-asylum-seeking-women-in-israel
#12
Tsega Gebreyesus, Nora Gottlieb, Zebib Sultan, Habtom Mehari Ghebrezghiabher, Wietse Tol, Peter J Winch, Nadav Davidovitch, Pamela J Surkan
OBJECTIVES: In recent years, there has been a mass migration of Eritreans (many seeking political asylum) into Israel after precarious irregular movement across international borders. This study qualitatively explores the structural barriers to family planning (i.e. contraceptive services) for Eritrean women in Israel that are rooted in their temporary legal status and the patchwork of family planning services. DESIGN/METHODS: From December 2012 to September 2013, we interviewed 25 key informants (NGO workers, researchers, Eritrean community activists, International NGO representatives and Ministry of Health officials) and 12 Eritrean asylum seekers...
December 28, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29274178/assessing-uncertainty-in-the-burden-of-hepatitis-c-virus-comparison-of-estimated-disease-burden-and-treatment-costs-in-the-uk
#13
Finn Gubay, Roisin Staunton, Cornelia Metzig, Ibrahim Abubakar, Peter J White
Hepatitis C virus (HCV) is a major and growing public health concern. We need to know the expected health burden and treatment cost, and understand uncertainty in those estimates, to inform policy-making and future research. Two models that have been important in informing treatment guidelines and assessments of HCV burden were compared by simulating cohorts of individuals with chronic HCV infection initially aged 20, 35, and 50 years. One model predicts that health losses (measured in Quality-Adjusted Life-Years (QALYs)) and treatment costs decrease with increasing initial age of the patients, whilst the other model predicts that below 40 years, costs increase and QALY losses change little with age, and above 40 years they decline with increasing age...
December 23, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29236534/health-outcomes-and-costs-of-social-work-services-a-systematic-review
#14
Gail Steketee, Abigail M Ross, Madeline K Wachman
BACKGROUND: Efforts to reduce expensive health service utilization, contain costs, improve health outcomes, and address the social determinants of health require research that demonstrates the economic value of health services in population health across a variety of settings. Social workers are an integral part of the US health care system, yet the specific contributions of social work to health and cost-containment outcomes are unknown. The social work profession's person-in-environment framework and unique skillset, particularly around addressing social determinants of health, hold promise for improving health and cost outcomes...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29214975/home-based-health-promotion-for-older-people-with-mild-frailty-the-homehealth-intervention-development-and-feasibility-rct
#15
Kate Walters, Rachael Frost, Kalpa Kharicha, Christina Avgerinou, Benjamin Gardner, Federico Ricciardi, Rachael Hunter, Ann Liljas, Jill Manthorpe, Vari Drennan, John Wood, Claire Goodman, Ana Jovicic, Steve Iliffe
BACKGROUND: Mild frailty or pre-frailty is common and yet is potentially reversible. Preventing progression to worsening frailty may benefit individuals and lower health/social care costs. However, we know little about effective approaches to preventing frailty progression. OBJECTIVES: (1) To develop an evidence- and theory-based home-based health promotion intervention for older people with mild frailty. (2) To assess feasibility, costs and acceptability of (i) the intervention and (ii) a full-scale clinical effectiveness and cost-effectiveness randomised controlled trial (RCT)...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29212477/nurse-health-and-lifestyle-modification-versus-standard-care-in-40-to-70-year-old-regional-adults-study-protocol-of-the-management-to-optimise-diabetes-and-metabolic-syndrome-risk-reduction-via-nurse-led-intervention-modern-randomized-controlled-trial
#16
Melinda J Carrington, Paul Zimmet
BACKGROUND: Metabolic syndrome (MetS), the clustering of multiple leading risk factors, predisposes individuals to increased risk for developing type 2 diabetes and/or cardiovascular disease (CVD). Cardio-metabolic disease risk increases with greater remoteness where specialist services are scarce. Nurse-led interventions are effective for the management of chronic disease. The aim of this clinical trial is to determine whether a nurse-implemented health and lifestyle modification program is more beneficial than standard care to reduce cardio-metabolic abnormalities and future risk of CVD and diabetes in individuals with MetS...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29210341/-without-this-program-women-can-lose-their-lives-migrant-women-s-experiences-with-the-safe-abortion-referral-programme-in-chiang-mai-thailand
#17
Ellen Tousaw, Ra Khin La, Grady Arnott, Orawee Chinthakanan, Angel M Foster
For displaced and migrant women in northern Thailand, access to health care is often limited, unwanted pregnancy is common, and unsafe abortion is a major contributor to maternal death and disability. Based on a pilot project and situational analysis research, in 2015 a multinational team introduced the Safe Abortion Referral Programme (SARP) in Chiang Mai, Thailand, to reduce the socio-linguistic, economic, documentation, and transportation barriers women from Burma face in accessing safe and legal abortion care in Thailand...
December 6, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29208190/preventing-blood-borne-virus-infection-in-people-who-inject-drugs-in-the-uk-systematic-review-stakeholder-interviews-psychosocial-intervention-development-and-feasibility-randomised-controlled-trial
#18
Gail Gilchrist, Davina Swan, April Shaw, Ada Keding, Sarah Towers, Noel Craine, Alison Munro, Elizabeth Hughes, Steve Parrott, Noreen Mdege, John Strang, Avril Taylor, Judith Watson
BACKGROUND: Opioid substitution therapy and needle exchanges have reduced blood-borne viruses (BBVs) among people who inject drugs (PWID). Some PWID continue to share injecting equipment. OBJECTIVES: To develop an evidence-based psychosocial intervention to reduce BBV risk behaviours and increase transmission knowledge among PWID, and conduct a feasibility trial among PWID comparing the intervention with a control. DESIGN: A pragmatic, two-armed randomised controlled, open feasibility trial...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29205150/a-pragmatic-multicentre-randomised-controlled-trial-comparing-stapled-haemorrhoidopexy-with-traditional-excisional-surgery-for-haemorrhoidal-disease-the-ethos-study
#19
Angus Jm Watson, Jonathan Cook, Jemma Hudson, Mary Kilonzo, Jessica Wood, Hanne Bruhn, Steven Brown, Brian Buckley, Finlay Curran, David Jayne, Malcolm Loudon, Ramesh Rajagopal, Alison McDonald, John Norrie
BACKGROUND: Haemorrhoids are a benign anorectal condition and are highly prevalent in the UK population. Treatments involve clinic-based procedures and surgery. The surgical procedures available include stapled haemorrhoidopexy (SH) and traditional haemorrhoidectomy (TH), and over 25,000 operations are performed for haemorrhoids annually in the UK. The disease is therefore important both to patients and to health service commissioners. Debate remains as to which of these surgical procedures is the most clinically effective and cost-effective...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29202862/coping-with-unusual-experiences-for-12-18-year-olds-cues-a-transdiagnostic-randomised-controlled-trial-of-the-effectiveness-of-cognitive-therapy-in-reducing-distress-associated-with-unusual-experiences-in-adolescent-mental-health-services-study-protocol-for
#20
Suzanne Jolley, Sophie Browning, Richard Corrigall, Kristin R Laurens, Colette Hirsch, Karen Bracegirdle, Kimberley Gin, Francesca Muccio, Catherine Stewart, Partha Banerjea, Elizabeth Kuipers, Philippa Garety, Majella Byrne, Juliana Onwumere, Evanthia Achilla, Paul McCrone, Richard Emsley
BACKGROUND: Childhood 'unusual experiences' (such as hearing voices that others cannot, or suspicions of being followed) are common, but can become more distressing during adolescence, especially for young people in contact with Child and Adolescent Mental Health Services (CAMHS). Unusual experiences that are distressing or have adverse life impact (UEDs) are associated with a range of current and future emotional, behavioural and mental health difficulties. Recommendations for psychological intervention are based on evidence from adult studies, with some support from small, pilot, child-specific evaluations...
December 4, 2017: Trials
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