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Ha Young Jang, Hyeong Jin Park, Kongara Damodar, Jin-Kyung Kim, Jong-Gab Jun
An efficient synthesis of dihydrostilbenes (1-5) and diarylpropanes (6-10) is achieved from the commercially available starting materials and Wittig-Horner reaction, Claisen-Schmidt condensation and hydrogenation as key steps. Later, their nitric oxide (NO) production inhibition effects were evaluated in lipopolysaccharide (LPS)-induced RAW-264.7 macrophages as an indicator of anti-inflammatory activity. All the tested compounds significantly decreased NO production in a concentration-dependent manner except compounds 2, 6 and 8 and did not show notable cytotoxicity except compound 1...
October 13, 2016: Bioorganic & Medicinal Chemistry Letters
Tammie Wei Yi Tham, Andrew Ti Heong Yeoh, Weibiao Zhou
Three different infant formulas (P1, P2 and P3) were characterised, and changes in their physicochemical properties under three different ageing conditions (i.e. 25°C, 45°C and 60°C) were established. At 60°C, all of the three powders exhibited increased moisture content, which was consistent with an increase in water activity. The GAB sorption model fitted for P1 while P2 and P3 did not follow the same sorption isotherm pattern. The glass transition temperature (Tg) for all of the powders significantly decreased at 45°C and 60°C...
March 15, 2017: Food Chemistry
Hyejin Cheon, Hye Jung Kim, Sang-Woo Lee, Do-Hoon Kim, Chang-Hee Lee, Seung Hyun Cho, Kyung Min Shin, So Mi Lee, Gab Chul Kim, Won Hwa Kim
PURPOSE: To evaluate the prevalence of and factors associated with internal mammary node (IMN) adenopathy on MRI and PET/CT used for initial staging in patients with operable breast cancer. METHODS: A total of 1320 patients diagnosed with invasive breast carcinoma between January 2011 and December 2015 underwent MRI and PET/CT for initial staging. The patients were considered to have IMN adenopathy when MRI revealed IMNs with the longest diameter of 5 mm or greater and a standardized uptake value greater than that of the mediastinal blood pool/contralateral parasternal area on PET/CT...
October 17, 2016: Breast Cancer Research and Treatment
Yoon Soo Kyung, Dalsan You, In Gab Jeong, Seungbong Han, Hong-Kyu Kim, Choung-Soo Kim
OBJECTIVES: To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in adult population. MATERIALS AND METHODS: Data were collected from 1,088 adult males (age ≥ 40 years) without history of prostate cancer who underwent more than 2 general health screenings between 2006 and 2013. Percent changes in prostate volume (PV) were assessed for 5 years after baseline measurements. Association between prostate growth and change in weight, WC and MetS status, respectively, were calculated using uni- and multivariate linear regression analyses...
October 6, 2016: Urology
Min Soo Jung, Jae Yoon Kim, Hyun Seung Lee, Chul Gab Lee, Han Soo Song
BACKGROUND: To identify adverse renal effects due to air pollution derived from a cement plant in Korea. Urinary n-acetyl-B-glucosaminidase (U-NAG) levels in residents living near a cement plant were compared to those in a group who lived farther away from the plant. METHODS: From June to August 2013 and from August to November 2014, laboratory tests for U-NAG and heavy metal were conducted on 547 study participants. Based on the level of air pollution exposure, subjects were divided into the "less exposed group," (LEG) which consisted of 66 persons who lived more than 5 km away from the cement plant, the "more exposed group from the rural area" (MEG-R), which consisted of 272 persons, and the "more exposed group from downtown area" (MEG-D), which consisted of 209 persons who lived within a 1 km radius of the cement plant...
2016: Annals of Occupational and Environmental Medicine
S Álvarez-Torrellas, M Muñoz, J A Zazo, J A Casas, J García
Chemically activated carbon materials prepared from pine sawdust-Onopordum acanthium L. were studied for the removal of diclofenac and naproxen from aqueous solution. Several carbons, using different proportions of precursors were obtained (carbon C1 to carbon C5) and the chemical modification by liquid acid and basic treatments of C1 were carried out. The textural properties of the carbons, evaluated by N2 adsorption-desorption isotherms, revealed that the treatments with nitric acid and potassium hydroxide dramatically reduced the specific surface area and the pore volume of the carbon samples...
December 1, 2016: Journal of Environmental Management
Manfred S Weiss, Kay Diederichs, Randy J Read, Santosh Panjikar, Gregory D Van Duyne, A Gregory Matera, Utz Fischer, Clemens Grimm
A recent publication by Seng et al. in this journal reports the crystallographic structure of refolded, full-length SMN protein and two disease-relevant derivatives thereof. Here, we would like to suggest that at least two of the structures reported in that study are incorrect. We present evidence that one of the associated crystallographic datasets is derived from a crystal of the bacterial Sm-like protein Hfq and that a second dataset is derived from a crystal of the bacterial Gab protein. Both proteins are frequent contaminants of bacterially overexpressed proteins which might have been co-purified during metal affinity chromatography...
August 29, 2016: Human Molecular Genetics
Sangjun Yoo, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: To evaluate the impact of tumor location on local recurrence in upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: Among UTUC patients who underwent radical nephroureterectomy, 192 with renal pelvic tumors and 161 with ureteral tumors were included. Local recurrence was divided into regional lymph node recurrence (rLNR) and surgical bed recurrence (SBR). RESULTS: During a mean follow-up of 73 months, local recurrence occurred in 33 patients (9...
July 21, 2016: Clinical Genitourinary Cancer
Dalsan You, Chunwoo Lee, In Gab Jeong, Cheryn Song, Jae-Lyun Lee, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: We evaluated the value of metastasectomy in patients treated with targeted therapy for metastatic renal cell carcinoma (mRCC). METHODS: The medical records of 325 patients who presented with mRCC were reviewed; among these patients, 33 underwent complete metastasectomy followed by targeted therapy (complete metastasectomy group), 29 underwent incomplete metastasectomy followed by targeted therapy (incomplete metastasectomy group), and 263 treated with targeted therapy alone (non-metastasectomy group)...
November 2016: Journal of Cancer Research and Clinical Oncology
Sangjun Yoo, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: This study aimed to investigate the effects of lymph node dissection (LND) on upper tract urothelial carcinoma (UTUC) without suspicious lymph node (LN) metastasis on preoperative imaging studies. METHODS: From 1998 to 2012, 418 UTUC patients without suspicious LN metastasis on preoperative imaging studies were included. Patients were divided into two groups according to the performance of LND. The effects of LND on oncological outcomes were assessed after adjusting other variables...
August 8, 2016: World Journal of Urology
Márcia Cavalcante Conceição, Tatiana Nunes Fernandes, Jaime Vilela de Resende
Freeze-dried guava pulp powders, formulated with the addition of sucrose (0-20 g/100 g pulp) and pectin (0-1.0 g/100 g pulp), were obtained, and their stability was evaluated with respect to the water adsorption isotherms, thermal analysis and microstructure. The GAB (Guggenheim-Anderson-de Boer), Peleg and BET (Brunauer-Emmett-Teller) models were used to evaluate the water adsorption. The microstructure was examined using optical microscopy with polarized light and scanning electron microscopy (SEM). The GAB and BET parameters showed that the moisture content of the monolayer (Xm) increases with increasing pectin concentration in the adsorption isotherms...
June 2016: Journal of Food Science and Technology
Muhammad Abdul Haq, Feroz Alam Jafri, Abid Hasnain
The present study aimed to characterize a biodegradable film produced from the polysaccharide of an indigenous plant Cordia myxa. Effect of plasticizer type (Glycerol, Sorbitol, PEG200 and PEG 400) and concentration (0-30 %) was studied on sorption and optical properties of the casted film. Increase in plasticizer concentration resulted in increase in equilibrium moisture content of the film and was supported by GAB model of sorption indicating that isotherms were of Type II. The monolayer value increased with the increase in plasticizer concentration with a peak of 0...
June 2016: Journal of Food Science and Technology
Yoon Kyoo Park, Woo Jin Jeong, Gab Jin Cheon
Serrated polyps are classified into 3 distinct types: hyperplastic polyp, sessile serrated adenoma, or transitional serrated adenoma. A serrated adenoma is a precursor lesion for colorectal carcinoma. Serrated polyps are commonly found in the colorectum but have rarely been described in other parts of the gastrointestinal tract. Serrated adenomas in the small intestine may represent aggressive lesions with high malignant potential, according to some reports. A 66-year-old man with no significant medical history underwent esophagogastroduodenoscopy (EGD) for general examination...
May 2016: Case Reports in Gastroenterology
K Deepika Devi, Sanjib Kr Paul, Jatindra K Sahu
In the study, the storage life of vacuum puffed honey powder at accelerated storage environment (90 % relative humidity and 36 °C) was computed by determining the sticky-point moisture content as the critical parameter of the honey powder. The value of monolayer moisture content in the GAB model was calculated to be 0.081 kg water/kg dry solids by fitting water activity and moisture sorption data. Shelf life of the honey powder was predicted to be 222 days when the powder was packaged in aluminum foil-laminated polyethylene pouches with permeability value of 5...
May 2016: Journal of Food Science and Technology
Emma Beck, Sune Bo, Matthias Gondan, Stig Poulsen, Liselotte Pedersen, Jesper Pedersen, Erik Simonsen
BACKGROUND: Evidence-based outpatient psychotherapeutic programs are first-line treatment of borderline personality disorder (BPD). Early and effective treatment of BPD is crucial to the prevention of its individual, psychosocial, and economic consequences. However, in spite of recent advantages in diagnosing adolescent BPD, there is a lack of cost-effective evidence-based treatment programs for adolescents. Mentalization-based treatment is an evidence-based program for BPD, originally developed for adults...
2016: Trials
Elif Aykın, Mustafa Erbaş
The aim of this research was to determine the quality properties and adsorption behavior of freeze-dried beef meat from the Biceps femoris and Semimembranosus muscles. Most quality properties of both muscles were similar apart from total fat content. Freeze-dried meat pieces were kept in ten different equilibrium levels of relative humidity (2.0-97.3%) at 5, 15, 25 and 30°C. The experimental data were evaluated using BET (Brunauer-Emmett-Teller) and GAB (Guggenheim, Anderson and deBoer) models. The equilibrium moisture contents of freeze-dried Biceps femoris were lower than those of Semimembranosus at all water activities and temperature...
November 2016: Meat Science
Tae-Won Jang, Yeon-Soon Ahn, Junsu Byun, Jong-In Lee, Kun-Hyung Kim, Youngki Kim, Han-Soo Song, Chul-Gab Lee, Young-Jun Kwon, Jin-Ha Yoon, Kyoungsook Jeong
OBJECTIVES: The job of firefighting can cause lumbar burden and low back pain. This study aimed to identify the association between age and lumbar intervertebral disc degeneration and whether the association differs between field and administrative (non-field) firefighters. METHODS: Subjects were selected using a stratified random sampling method. Firefighters were stratified by geographic area, gender, age and type of job. First, 25 fire stations were randomly sampled considering regional distribution...
2016: BMJ Open
Xiao-dong Liu, Jian-heng Chen, Hai-yuan Li, Hao Li, Shuo Yin
OBJECTIVE: To investigate the expression of type 3 acid-sensing ion channels (ASIC3) in bladder tissue of over active bladder (OAB) rat model. METHODS: Sixty adult female rats were randomly divided into control group (intraperitoneal injection of 0.9% sodium chloride), GAB group (intraperitoneal injection of cyclophosphamide) and the intervention group (OAB rats treated with ASIC3 inhibitor amiloride). The rats underwent urodynamic testing. The bladder tissues were collected for pathological examination, while the expressions of ASIC3 were measured by the methods of immunohistochemistry, RT-PCR and Western blot...
March 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Dalsan You, Myoung Jin Jang, Bo Hyun Kim, Ki Ryung Choi, Chunwoo Lee, Geehyun Song, Ha Chul Shin, In Gab Jeong, Nayoung Suh, Yong Man Kim, Tai Young Ahn, Choung-Soo Kim
BACKGROUND AIMS: Although clinical studies using stem cells to treat erectile dysfunction have been performed or are ongoing, there is little consensus on the optimal protocol. We aimed to develop a protocol optimizing human bone marrow-derived mesenchymal stromal cell (hBMSC) therapy in a rat model of cavernous nerve injury. METHODS: We performed, in order, a dose-finding study, a toxicokinetic study of hBMSCs, and a study to determine the timing and number of cell injections...
July 2016: Cytotherapy
Paul E Hughes, Karen Rex, Sean Caenepeel, Yajing Yang, Yihong Zhang, Martin A Broome, Hue T Kha, Teresa L Burgess, Benny Amore, Paula J Kaplan-Lefko, Jodi Moriguchi, Jonathan Werner, Michael A Damore, Daniel Baker, Deborah M Choquette, Jean-Christophe Harmange, Robert Radinsky, Richard Kendall, Isabelle Dussault, Angela Coxon
The MET receptor tyrosine kinase is involved in cell growth, survival, and invasion. Clinical studies with small molecule MET inhibitors have shown the role of biomarkers in identifying patients most likely to benefit from MET-targeted therapy. AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the MET receptor. Herein, we describe AMG 337 preclinical activity and mechanism of action in MET-dependent tumor models. These studies suggest MET is the only therapeutic target for AMG 337...
July 2016: Molecular Cancer Therapeutics
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