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https://www.readbyqxmd.com/read/28161349/obesity-as-a-risk-factor-for-unfavorable-disease-in-low-risk-prostate-cancer-and-its-relationship-with-anatomic-location-of-tumor
#1
In Gab Jeong, Sangjun Yoo, Chunwoo Lee, Myong Kim, Dalsan You, Cheryn Song, Sungchan Park, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: To investigate the influence of obesity on unfavorable disease in low-risk prostate cancer eligible for active surveillance and verify the underlying relationship with tumor location. MATERIALS AND METHODS: We analyzed 890 patients with biopsy Gleason score 6 who underwent radical prostatectomy for prostate cancer via multicore (≥12) biopsy at our institution. Unfavorable disease was defined as primary Gleason pattern ≥4 or pathologic stage ≥T3. Multivariate logistic regression analysis was performed to identify factors associated with unfavorable disease...
February 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28145654/preserving-renal-function-through-partial-nephrectomy-depends-on-tumor-complexity-in-t1b-renal-tumors
#2
Sangjun Yoo, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Choung Soo Kim, Hanjong Ahn, Cheryn Song
This study aimed to determine patients with T1b renal cell carcinoma (RCC) who could benefit from partial nephrectomy (PN) and method to identify them preoperatively using nephrometry score (NS). From a total of 483 radical nephrectomy (RN)-treated patients and 40 PN-treated patients who received treatment for T1b RCC between 1995 and 2010, 120 patients identified through 1:2 propensity-score matching were included for analysis. Probability of chronic kidney disease (CKD) until postoperative 5-years was calculated and regressed with respect to the surgical method and NS...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28145435/processable-high-internal-phase-pickering-emulsions-using-depletion-attraction
#3
KyuHan Kim, Subeen Kim, Jiheun Ryu, Jiyoon Jeon, Se Gyu Jang, Hyunjun Kim, Dae-Gab Gweon, Won Bin Im, Yosep Han, Hyunjung Kim, Siyoung Q Choi
High internal phase emulsions have been widely used as templates for various porous materials, but special strategies are required to form, in particular, particle-covered ones that have been more difficult to obtain. Here, we report a versatile strategy to produce a stable high internal phase Pickering emulsion by exploiting a depletion interaction between an emulsion droplet and a particle using water-soluble polymers as a depletant. This attractive interaction facilitating the adsorption of particles onto the droplet interface and simultaneously suppressing desorption once adsorbed...
February 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28139370/lymph-node-density-vs-the-american-joint-committee-on-cancer-tnm-nodal-staging-system-in-node-positive-bladder-cancer-in-patients-undergoing-extended-or-super-extended-pelvic-lymphadenectomy
#4
Donghyun Lee, Sangjun Yoo, Dalsan You, Bumsik Hong, Yong Mee Cho, Jun Hyuk Hong, Choung-Soo Kim, Hanjonh Ahn, Jae Y Ro, In Gab Jeong
PURPOSE: We compared the prognostic value of the American Joint Committee on Cancer (AJCC) TNM nodal staging system with that of lymph node (LN) density in patients with LN-positive bladder cancer who received extended or super-extended pelvic lymphadenectomy. METHODS: Of the 1,018 patients, who underwent radical cystectomy and pelvic lymphadenectomy between February 2005 and August 2014, 110 patients with LN metastases with extended (n = 68) or super-extended (n = 42) pelvic lymphadenectomy were included...
January 27, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28115166/gab3-is-required-for-human-colorectal-cancer-cell-proliferation
#5
Shihao Xiang, Na Wang, Pingping Hui, Jiali Ma
Here, we focused on the potential function of Gab3, an uncommon Gab family protein, in human colorectal cancer (CRC) cells. We found that Gab3 was only expressed in human colon cancer tissues as well as in established (HCT-116 and HT-29 lines) and primary human CRC cells. It was however absent in normal human colon cancer tissues and in FHC colon epithelial cells. Knockdown of Gab3 by targeted-shRNAs inhibited proliferation of the CRC cells. Reversely, exogenous over-expression of Gab3 promoted CRC cell proliferation...
January 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28111189/mapping-the-critical-gestational-age-at-birth-that-alters-brain-development-in-preterm-born-infants-using-multi-modal-mri
#6
Dan Wu, Linda Chang, Kentaro Akazawa, Kumiko Oishi, Jon Skranes, Thomas Ernst, Kenichi Oishi
Preterm birth adversely affects postnatal brain development. In order to investigate the critical gestational age at birth (GAB) that alters the developmental trajectory of gray and white matter structures in the brain, we investigated diffusion tensor and quantitative T2 mapping data in 43 term-born and 43 preterm-born infants. A novel multivariate linear model-the change point model, was applied to detect change points in fractional anisotropy, mean diffusivity, and T2 relaxation time. Change points captured the "critical" GAB value associated with a change in the linear relation between GAB and MRI measures...
January 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28068921/co-localization-of-major-quantitative-trait-loci-for-pod-size-and-weight-to-a-3-7%C3%A2-cm-interval-on-chromosome-a05-in-cultivated-peanut-arachis-hypogaea-l
#7
Huaiyong Luo, Xiaoping Ren, Zhendong Li, Zhijun Xu, Xinping Li, Li Huang, Xiaojing Zhou, Yuning Chen, Weigang Chen, Yong Lei, Boshou Liao, Manish K Pandey, Rajeev K Varshney, Baozhu Guo, Xiangguo Jiang, Fei Liu, Huifang Jiang
BACKGROUND: Cultivated peanut (Arachis hypogaea L.), an important source of edible oil and protein, is widely grown in tropical and subtropical areas of the world. Genetic improvement of yield-related traits is essential for improving yield potential of new peanut varieties. Genomics-assisted breeding (GAB) can accelerate the process of genetic improvement but requires linked markers for the traits of interest. In this context, we developed a recombinant inbred line (RIL) mapping population (Yuanza 9102 × Xuzhou 68-4) with 195 individuals and used to map quantitative trait loci (QTLs) associated with three important pod features, namely pod length, pod width and hundred-pod weight...
January 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28027398/physiologically-based-pharmacokinetic-predictions-of-intestinal-bcrp-mediated-effect-of-telmisartan-on-the-pharmacokinetics-of-rosuvastatin-in-humans
#8
Soo Hyeon Bae, Wan-Su Park, Seunghoon Han, Gab-Jin Park, Jongtae Lee, Taegon Hong, Sangil Jeon, Dong-Seok Yim
It was recently reported that the Cmax and AUC of rosuvastatin increases when it is coadministered with telmisartan. The aim of this study was to explore the mechanism of the interaction of telmisartan and rosuvastatin. A full-PBPK model of telmisartan was developed, and the rosuvastatin model in Simcyp (version 15)'s drug library was modified to reflect ethnic differences in rosuvastatin exposure. PK characteristics, including intestinal and hepatic transporter / enzyme specificities of telmisartan and rosuvastatin, were incorporated into the PBPK models to simulate a rosuvastatin (20 mg) - telmisartan (80 mg) multiple dose drug interaction study...
December 27, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27989785/prognostic-value-of-vascular-endothelial-growth-factor-vegf-vegf-receptor-2-platelet-derived-growth-factor-%C3%AE-pdgf-%C3%AE-and-pdgf-%C3%AE-receptor-expression-in-papillary-renal-cell-carcinoma
#9
Myong Kim, Mooyoung Sohn, Myungsun Shim, Seung-Kwon Choi, Myungchan Park, Eunna Kim, Heounjeong Go, Yangsoon Park, Yong Mee Cho, Jae Y Ro, In Gab Jeong, Cheryn Song, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn
The Prognostic value of the expression of vascular endothelial growth factor (VEGF), VEGF receptor 2 (VEGFR2), platelet-derived growth factor (PDGF)-β, and PDGF receptor (PDGFR)-β in papillary renal cell carcinoma (pRCC) is unknown. A total of 145 patients, who were confirmed to have pRCC, were analyzed. Expression levels of molecular markers were assessed via immunohistochemistry. The median follow-up period for all patients was 52.0 (interquartile range, 34.5-90.5) months. Among the cohort of 145 patients, high VEGF expression was observed in 100 (69...
December 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27979124/application-of-cashew-tree-gum-on-the-production-and-stability-of-spray-dried-fish-oil
#10
Diego Alvarenga Botrel, Soraia Vilela Borges, Regiane Victória de Barros Fernandes, Rosemar Antoniassi, Adelia Ferreira de Faria-Machado, Judith Pessoa de Andrade Feitosa, Regina Celia Monteiro de Paula
Evaluation of cashew gum compared to conventional materials was conducted regarding properties and oxidative stability of spray-dried fish oil. Emulsions produced with cashew gum showed lower viscosity when compared to Arabic gum. The particle size was larger (29.9μm) when cashew gum was used, and the encapsulation efficiency reached 76%, similar to that of modified starch but higher than that for Arabic gum (60%). The oxidation process for the surface oil was conducted and a relative lower formation of oxidation compounds was observed for the cashew gum treatment...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27874078/glutamate-dehydrogenase-activator-bch-stimulating-reductive-amination-prevents-high-fat-high-fructose-diet-induced-steatohepatitis-and-hyperglycemia-in-c57bl-6j-mice
#11
Seung Jin Han, Sung-E Choi, Sang-A Yi, Jong Gab Jung, Ik-Rak Jung, Maureen Shin, Seok Kang, Hyunhee Oh, Hae Jin Kim, Dae Jung Kim, Ji Eun Kwon, Cheol Soo Choi, Kwan Woo Lee, Yup Kang
Individuals with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) induced by high calorie western diet are characterized by enhanced lipogenesis and gluconeogenesis in the liver. Stimulation of reductive amination may shift tricarboxylic acid cycle metabolism for lipogenesis and gluconeogenesis toward glutamate synthesis with increase of NAD+/NADH ratio and thus, ameliorate high calorie diet-induced fatty liver and hyperglycemia. Stimulation of reductive amination through glutamate dehydrogenase (GDH) activator 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) reduced both de novo lipogenesis and gluconeogenesis but increased the activities of sirtuins and AMP-activated kinase in primary hepatocytes...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27861634/molecular-characterization-of-striated-muscle-specific-gab1-isoform-as-a-critical-signal-transducer-for-neuregulin-1-erbb-signaling-in-cardiomyocytes
#12
Taku Yasui, Takeshi Masaki, Yoh Arita, Tomohiko Ishibashi, Tadakatsu Inagaki, Makoto Okazawa, Toru Oka, Wataru Shioyama, Keiko Yamauchi-Takihara, Issei Komuro, Yasushi Sakata, Yoshikazu Nakaoka
Grb2-associated binder (Gab) docking proteins regulate signals downstream of a variety of growth factors and receptor tyrosine kinases. Neuregulin-1 (NRG-1), a member of epidermal growth factor family, plays a critical role for cardiomyocyte proliferation and prevention of heart failure via ErbB receptors. We previously reported that Gab1 and Gab2 in the myocardium are essential for maintenance of myocardial function in the postnatal heart via transmission of NRG-1/ErbB-signaling through analysis of Gab1/Gab2 cardiomyocyte-specific double knockout mice...
2016: PloS One
https://www.readbyqxmd.com/read/27857286/high-speed-time-resolved-laser-scanning-microscopy-using-the-line-to-pixel-referencing-method
#13
Jiheun Ryu, Jayul Kim, Hyunjun Kim, Jae-Heon Jeong, Hak-Jun Lee, Hongki Yoo, Dae-Gab Gweon
Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to visualize photophysical characteristics of biological targets. However, conventional FLIM methods have some limitations that restrict obtaining high-precision images in real time. Here, we propose a high-speed time-resolved laser-scanning microscopy by incorporating a novel line-to-pixel referencing method into the previously suggested analog mean-delay (AMD) method. The AMD method dramatically enhances the photon accumulation speed for achieving the certain precision compared to the time-correlated single-photon counting (TCSPC) method while maintaining high photon efficiency...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27831916/retrospective-evaluation-of-the-clinical-utility-of-serological-biomarkers-in-chinese-patients-with-inflammatory-bowel-disease-2-year-clinical-experience
#14
Shulan Zhang, Jing Luo, Ji Li, Ziyan Wu, Chaojun Hu, Ping Li, Chuiwen Deng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
BACKGROUND: Antibodies to saccharomyces cerevisiae (ASCA), antibodies to perinuclear anti-neutrophil cytoplasmic (pANCA), pancreatic autoantibodies (PAB) and antibodies against intestinal goblet cells (GAB) are important in diagnosing Crohn's disease (CD) and ulcerative colitis (UC). However, little is known about their diagnostic value in real clinical practice in China. This retrospective study aimed to present our 2-year clinical experience with those biomarkers in diagnosis of CD and UC...
November 10, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27793798/epithelial-disruption-of-gab1-perturbs-surfactant-homeostasis-and-predisposes-mice-to-lung-injuries
#15
Kai Wang, Shenlu Qin, Zuyu Liang, Yun Zhang, Yingchun Xu, An Chen, Xiaohong Guo, Hongqiang Cheng, Xue Zhang, Yuehai Ke
GRB2-associated-binding protein 1 (Gab1) belongs to Gab adaptor family, which integrates multiple signals in response to the epithelial growth factors. Recent genetic studies identified genetic variants of human Gab1 gene as potential risk factors of asthmatic inflammation. However, the functions of Gab1 in lungs remain largely unknown. Alveolar type-II cells (AT-IIs) are responsible for surfactant homeostasis and essentially regulate lung inflammation following various injuries (3). In this study, in vitro knockdown of Gab1 was shown to decrease the surfactant proteins (SPs) levels in AT-IIs...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27785917/risk-of-intravesical-recurrence-after-ureteroscopic-biopsy-for-upper-tract-urothelial-carcinoma-does-the-location-matter
#16
Sangjun Yoo, Dalsan You, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, In Gab Jeong
INTRODUCTION: To investigate whether ureteroscopic biopsy (URS-Bx) for upper tract urothelial carcinoma (UTUC) before radical nephroureterectomy affects intravesical recurrence (IVR). PATIENTS AND METHODS: Of the 515 patients receiving radical nephroureterectomy for UTUC between 1998 and 2012, 387 patients were included for the analysis. URS-Bx was performed in 69 patients (17.8%). Patients were stratified according to tumor location, and the impact of URS-Bx on IVR was evaluated after adjusting for other clinicopathologic variables...
November 29, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27780946/-a-case-of-cecal-endometriosis-presenting-as-subepithelial-tumor
#17
Min Sik Hwang, Young Don Kim, Sa Young Shin, Jae Hyuck Jun, Jong Sam Hong, Dae Woon Eom, Gab Jin Cheon
Endometriosis is a benign gynecologic disease, characterized by the presence and growth of functional endometrial-like tissue outside uterus. This ectopic endometrial tissue is most commonly found in the peritoneum, ovaries and uterosacral ligaments, but extremely rarely there is involvement of the appendix or cecum. Here we report a case of cecal endometriosis presenting as a subepithelial tumor diagnosed by surgical excision.
October 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27777005/dihydrostilbenes-and-diarylpropanes-synthesis-and-in-vitro-pharmacological-evaluation-as-potent-nitric-oxide-production-inhibition-agents
#18
Ha Young Jang, Hyeong Jin Park, Kongara Damodar, Jin-Kyung Kim, Jong-Gab Jun
An efficient synthesis of dihydrostilbenes (1-5) and diarylpropanes (6-10) is achieved from the commercially available starting materials and Wittig-Horner reaction, Claisen-Schmidt condensation and hydrogenation as key steps. Later, their nitric oxide (NO) production inhibition effects were evaluated in lipopolysaccharide (LPS)-induced RAW-264.7 macrophages as an indicator of anti-inflammatory activity. All the tested compounds significantly decreased NO production in a concentration-dependent manner except compounds 2, 6 and 8 and did not show notable cytotoxicity except compound 1...
November 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27765206/characterisation-of-aged-infant-formulas-and-physicochemical-changes
#19
Tammie Wei Yi Tham, Andrew Ti Heong Yeoh, Weibiao Zhou
Three different infant formulas (P1, P2 and P3) were characterised, and changes in their physicochemical properties under three different ageing conditions (i.e. 25°C, 45°C and 60°C) were established. At 60°C, all of the three powders exhibited increased moisture content, which was consistent with an increase in water activity. The GAB sorption model fitted for P1 while P2 and P3 did not follow the same sorption isotherm pattern. The glass transition temperature (Tg) for all of the powders significantly decreased at 45°C and 60°C...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27752848/internal-mammary-node-adenopathy-on-breast-mri-and-pet-ct-for-initial-staging-in-patients-with-operable-breast-cancer-prevalence-and-associated-factors
#20
Hyejin Cheon, Hye Jung Kim, Sang-Woo Lee, Do-Hoon Kim, Chang-Hee Lee, Seung Hyun Cho, Kyung Min Shin, So Mi Lee, Gab Chul Kim, Won Hwa Kim
PURPOSE: To evaluate the prevalence of and factors associated with internal mammary node (IMN) adenopathy on MRI and PET/CT used for initial staging in patients with operable breast cancer. METHODS: A total of 1320 patients diagnosed with invasive breast carcinoma between January 2011 and December 2015 underwent MRI and PET/CT for initial staging. The patients were considered to have IMN adenopathy when MRI revealed IMNs with the longest diameter of 5 mm or greater and a standardized uptake value greater than that of the mediastinal blood pool/contralateral parasternal area on PET/CT...
December 2016: Breast Cancer Research and Treatment
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