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https://www.readbyqxmd.com/read/28537505/the-impact-of-surgeon-volume-on-perioperative-outcomes-and-cost-for-patients-receiving-robotic-partial-nephrectomy
#1
Yash S Khandwala, In Gab Jeong, Jae Heon Kim, Deok Hyun Han, Shufeng Li, Ye Wang, Steven L Chang, Benjamin I Chung
INTRODUCTION: Little is known about the impact of surgeon volume on the succcess of the robot-assisted partial nephrectomy (RAPN). The objective of this study was to compare the perioperative outcomes and cost related to RAPN by annual surgeon volumes. PATIENTS AND METHODS: Using the Premier Hospital Database, we retrospectively analyzed 39,773 patients who underwent RAPN between 2003 and 2015 in the USA. Surgeons for each index case were grouped into quintiles for each respective year...
May 24, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28516143/change-point-analysis-data-of-neonatal-diffusion-tensor-mri-in-preterm-and-term-born-infants
#2
Dan Wu, Linda Chang, Kentaro Akazawa, Kumiko Oishi, Jon Skranes, Thomas Ernst, Kenichi Oishi
The data presented in this article are related to the research article entitled "Mapping the Critical Gestational Age at Birth that Alters Brain Development in Preterm-born Infants using Multi-Modal MRI" (Wu et al., 2017) [1]. Brain immaturity at birth poses critical neurological risks in the preterm-born infants. We used a novel change-point model to analyze the critical gestational age at birth (GAB) that could affect postnatal development, based on diffusion tensor MRI (DTI) acquired from 43 preterm and 43 term-born infants in 126 brain regions...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28507291/construction-of-genotyping-by-sequencing-based-high-density-genetic-maps-and-qtl-mapping-for-fusarium-wilt-resistance-in-pigeonpea
#3
Rachit K Saxena, Vikas K Singh, Sandip M Kale, Revathi Tathineni, Swathi Parupalli, Vinay Kumar, Vanika Garg, Roma R Das, Mamta Sharma, K N Yamini, S Muniswamy, Anuradha Ghanta, Abhishek Rathore, C V Sameer Kumar, K B Saxena, P B Kavi Kishor, Rajeev K Varshney
Fusarium wilt (FW) is one of the most important biotic stresses causing yield losses in pigeonpea. Genetic improvement of pigeonpea through genomics-assisted breeding (GAB) is an economically feasible option for the development of high yielding FW resistant genotypes. In this context, two recombinant inbred lines (RILs) (ICPB 2049 × ICPL 99050 designated as PRIL_A and ICPL 20096 × ICPL 332 designated as PRIL_B) and one F2 (ICPL 85063 × ICPL 87119) populations were used for the development of high density genetic maps...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28491006/glycolysis-inhibition-the-gift-of-gab-a
#4
COMMENT
Adam L Hartman
No abstract text is available yet for this article.
March 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/28485874/abcb1-gen-polymorphismus-in-einer-polnischen-kohorte-ist-mit-risiko-f%C3%A3-r-bull%C3%A3-ses-pemphigoid-assoziiert
#5
Mariola Rychlik-Sych, Małgorzata Barańska, Michał Dudarewicz, Jadwiga Skrętkowicz, Agnieszka Żebrowska, Jacek Owczarek, Elżbieta Waszczykowska
HINTERGRUND UND ZIELE: Polymorphismen im ABCB1-Gen, das für das P-Glykoprotein kodiert, können die intrazelluläre Konzentration von Xenobiotika beeinflussen und so zur Entwicklung von Autoimmunerkrankungen, einschließlich des bullösen Pemphigoids (BP), beitragen. In der vorliegenden Studie sollte untersucht werden, ob in einer polnischen Kohorte die C3435T- und G2677T/A-Polymorphismen im ABCB1-Gen mit dem Risiko für ein BP assoziiert sind. PATIENTEN UND METHODIK: Die Studie umfasste 71 Patienten mit BP und 156 gesunde Probanden...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28480188/erratum-addition-of-funding-statement-clinical-characteristics-of-papillary-thyroid-carcinoma-arising-from-the-pyramidal-lobe
#6
Sang Gab Yoon, Jin Wook Yi, Chan-Yong Seong, Jong-Kyu Kim, Su-Jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
[This corrects the article on p. 123 in vol. 92, PMID: 28289665.].
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28451753/histologic-subtype-needs-to-be-considered-after-partial-nephrectomy-in-patients-with-pathologic-t1a-renal-cell-carcinoma-papillary-vs-clear-cell-renal-cell-carcinoma
#7
Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: We compared the oncological outcomes of papillary renal cell carcinoma (pRCC) with clear cell renal cell carcinoma (ccRCC) after partial nephrectomy (PN) in patients with pathologic T1a RCC. METHODS: After excluding patients with synchronous multiple renal tumors, familial RCC, and pathologic stage T1b or above, 759 patients with ccRCC and 84 patients with pRCC were included. We assessed the impact of histologic subtypes on oncologic outcomes after PN in patients with pathologic T1a RCC (median follow-up duration, 67 months)...
April 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28436380/tenofovir-disoproxil-fumarate-monotherapy-is-superior-to-entecavir-adefovir-combination-therapy-in-patients-with-suboptimal-response-to-lamivudine-adefovir-therapy-for-nucleoside-resistant-hbv-a-96-week-prospective-multicenter-trial
#8
Sae Hwan Lee, Gab Jin Cheon, Hong Soo Kim, Sang Gyune Kim, Young Seok Kim, Soung Won Jeong, Jae Young Jang, Boo Sung Kim, Baek Gyu Jun, Young Don Kim, Dae Won Jun, Joo Hyun Sohn, Tae Yeob Kim, Byung Seok Lee
BACKGROUND: A complete virologic response is closely related to the long-term outcome of patients with chronic hepatitis B and prevention of emerging hepatitis B virus (HBV) mutations. We aimed to evaluate the efficacy of tenofovir disoproxil fumarate (TDF) monotherapy compared to entecavir-adefovir dipivoxil (ETV-ADV) combination therapy in patients with suboptimal responses to long-term lamivudine-adefovir dipivoxil (LAM-ADV) therapy for nucleoside analogue-resistant chronic hepatitis B...
April 24, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28435210/incidence-of-interface-fluid-syndrome-after-laser-in-situ-keratomileusis-in-egyptian-patients
#9
Amr A Gab-Alla
PURPOSE: To determine the incidence of interface fluid syndrome (IFS) secondary to steroid-induced elevation of intraocular pressure (IOP) following laser in situ keratomileusis (LASIK) in myopic Egyptian patients. METHODS: This retrospective case series study was conducted at El-Gowhara Private Eye Center. The medical records of 1,807 patients (3,489 eyes), who underwent LASIK to correct myopia from April 2012 to December 2015 were included. The patients were operated on and reviewed by one surgeon (AAG) for IFS after LASIK associated with elevation of IOP (as compared to preoperative values)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28430745/bortezomib-pharmacokinetics-in-tumor-response-and-peripheral-neuropathy-in-multiple-myeloma-patients-receiving-bortezomib-containing-therapy
#10
Sung-Eun Lee, Kyungmee Choi, Seunghoon Han, Jongtae Lee, Taegon Hong, Gab-Jin Park, Dong-Seok Yim, Chang-Ki Min
The usefulness of pharmacokinetics of bortezomib for multiple myeloma (MM) with respect to the maximum response to bortezomib and bortezomib-induced peripheral neuropathy (BIPN) development was studied. Maximum response to subcutaneous bortezomib therapy and BIPN occurrence for the first 12 weeks of treatment in 35 MM patients treated by bortezomib-dexamethasone (VD) and bortezomib-melphalan-prednisone (VMP) were evaluated. On day 1 of cycle 1, seven whole-blood samples were collected for 3 h after dosing completion to obtain the maximum plasma concentration and area under the time-concentration curve during 3 h postdose (AUC0-3) in each patient...
July 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28408803/drug-drug-interaction-of-microdose-and-regular-dose-omeprazole-with-a-cyp2c19-inhibitor-and-inducer
#11
Gab-Jin Park, Soo Hyeon Bae, Wan-Su Park, Seunghoon Han, Min-Ho Park, Seok-Ho Shin, Young G Shin, Dong-Seok Yim
PURPOSE: A microdose drug-drug interaction (DDI) study may be a valuable tool for anticipating drug interaction at therapeutic doses. This study aimed to compare the magnitude of DDIs at microdoses and regular doses to explore the applicability of a microdose DDI study. PATIENTS AND METHODS: Six healthy male volunteer subjects were enrolled into each DDI study of omeprazole (victim) and known perpetrators: fluconazole (inhibitor) and rifampin (inducer). For both studies, the microdose (100 μg, cold compound) and the regular dose (20 mg) of omeprazole were given at days 0 and 1, respectively...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28404588/adaptive-functional-change-of-the-contralateral-kidney-after-partial-nephrectomy
#12
Se Young Choi, Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Partial nephrectomy aims to maintain renal function by nephron sparing; however, functional changes in the contralateral kidney remain unknown. We evaluate the functional change in the contralateral kidney using a diethylene triamine penta-acetic acid (DTPA) renal scan and determine factors predicting contralateral kidney function after partial nephrectomy. A total of 699 patients underwent partial nephrectomy, with a DTPA scan before and after surgery to assess the separate function of each kidney. Patients were divided into three groups according to initial contralateral glomerular filtration rate (GFR; group 1: <30 ml/min/1...
April 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28401380/fate-of-newly-developed-pulmonary-embolism-after-surgery-for-renal-cell-carcinoma-with-vena-cava-thrombus
#13
Sangjun Yoo, Sang Hoon Song, Heounjeong Go, Dalsan You, Cheryn Song, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, In Gab Jeong
PURPOSE: Pulmonary embolism with viable tumor cells developed after surgery for renal cell carcinoma may metastasize to lung. We investigated the incidence and fate of newly developed pulmonary embolism after surgery for renal cell carcinoma with vena cava thrombus. METHODS: Among 4549 renal cell carcinoma patients treated with curative surgery at our institute from 1998 to 2015, 81 non-metastatic renal cell carcinoma patients with vena cava thrombus were included...
April 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28370761/preoperative-mri-features-associated-with-lymphovascular-invasion-in-node-negative-invasive-breast-cancer-a-propensity-matched-analysis
#14
Hyejin Cheon, Hye Jung Kim, So Mi Lee, Seung Hyun Cho, Kyung Min Shin, Gab Chul Kim, Ji Young Park, Won Hwa Kim
PURPOSE: In node-negative disease, the presence of lymphovascular invasion (LVI) is reported to be an unfavorable prognostic factor. Thus, the aim of this study was to evaluate whether preoperative breast MRI features are associated with LVI in patients with node-negative invasive breast cancer by a propensity-matched analysis. MATERIALS AND METHODS: Among 389 patients with node-negative invasive ductal breast cancer who had preoperative breast 3.0 Tesla MRI with precontrast T2-weighted fat-suppressed, pre- and dynamic postcontrast T1-weighted fat-suppressed sequences, 61 patients with LVI (LVI group) were matched with 183 patients without LVI (no LVI group) at a ratio of 1:3 in terms of age, histologic grade, tumor size, and hormone receptor status...
April 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28367406/cataloguing-the-bacterial-community-of-the-great-salt-plains-oklahoma-using-16s-rrna-based-metagenomics-pyrosequencing
#15
Ahmed H Gad
The Great Salt Plains of Oklahoma (GSP) is an extreme region, a hypersaline environment from marine origin and a unique area of the Salt National Wild Refuge in the north-central region of Oklahoma. In this study we analyzed the diversity and distribution of bacteria in two habitats; vegetated areas (GAB) and salt flat areas (GAS) in the sediments of GSP using the high-throughput techniques of 16S rRNA gene amplicon (V1-V2 regions) metagenomics-454 pyrosequencing. The filtered sequences resulted to a total of 303,723 paired end reads were generated, assigned into 1646 numbers of OTUs and 56...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28365982/hygroscopic-swelling-determination-of-cellulose-nanocrystal-cnc-films-by-polarized-light-microscopy-digital-image-correlation
#16
Shikha Shrestha, Jairo A Diaz, Siavash Ghanbari, Jeffrey P Youngblood
The coefficient of hygroscopic swelling (CHS) of self-organized and shear-oriented cellulose nanocrystal (CNC) films was determined by capturing hygroscopic strains produced as result of isothermal water vapor intake in equilibrium. Contrast enhanced microscopy digital image correlation enabled the characterization of dimensional changes induced by the hygroscopic swelling of the films. The distinct microstructure and birefringence of CNC films served in exploring the in-plane hygroscopic swelling at relative humidity values ranging from 0% to 97%...
April 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28365708/resistenzentwicklung-und-pr%C3%A3-diktive-marker-beim-metastasierten-prostatakarzinom
#17
Christof Bernemann, Martin Bögemann, Julie Steinestel, Andreas Jan Schrader
Anders als bei vielen anderen Krebserkrankungen gab es beim Prostatakarzinom lange Zeit keinen Ansatz für eine individualisierte Therapie. Seit der Zulassung von mehreren modernen Wirkstoffen für die Therapie des fortgeschrittenen Stadiums ändert sich dies allmählich. Zunächst galt die Androgenrezeptor-Splice-Variante AR-V7 als vielversprechender Biomarker für die Therapiesteuerung, woran sich zunehmend Zweifel mehren. Inzwischen gibt es jedoch eine Reihe von weiteren neuen, noch nicht zugelassenen und nicht (nur) auf den Androgenrezeptor fokussierenden Therapieansätzen, die auch beim fortgeschrittenen Prostatakarzinom eine personalisierte Medizin wahrscheinlicher machen...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28365706/metastasiertes-kastrationsresistentes-prostatakarzinom-grunds%C3%A3-tzliche-therapieoptionen-und-progression
#18
David Pfister
In der Entwicklung des Prostatakarzinoms spielen Androgene und der Androgenrezeptor eine zentrale Rolle. Über Jahrzehnte war die konventionelle Androgendeprivationstherapie (ADT) die wichtigste Behandlungsoption im metastasierten Stadium. Trotz initialen Ansprechens auf eine ADT entwickelt sich im Verlauf in der Regel ein metastasiertes kastrationsresistentes Prostatakarzinom (mCRPC). Für dieses Stadium gab es jahrelang keine Therapie, für die eine Verlängerung des Überlebens gezeigt werden konnte. Dies änderte sich erst 2004 mit der Studie TAX 327 zur Wirksamkeit von Docetaxel...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28351380/mirna-expression-in-the-cartilage-of-patients-with-osteoarthritis
#19
Marta Kopańska, Dariusz Szala, Joanna Czech, Natalia Gabło, Krzysztof Gargasz, Mateusz Trzeciak, Izabela Zawlik, Sławomir Snela
BACKGROUND: Osteoarthritis (OA), the most prevalent disease of articulating joints, is a complex multifactorial disease caused by genetic, mechanical, and environmental factors. In this research, we evaluated miRNA expression in OA. METHODS: Forty tissue samples from 29 patients undergoing joint replacement for OA were evaluated. Tissue from two control patients undergoing hip replacement not related to OA was used as a control. Total RNA (containing miRNA species) from cartilage was isolated using a mirVana miRNA Isolation Kit...
March 28, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28345670/domain-dependent-effects-of-insulin-and-igf-1-receptors-on-signalling-and-gene-expression
#20
Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M Dreyfuss, Brian T O'Neill, Alfred K Ramirez, Hui Pan, Jonathon N Winnay, Jeremie Boucher, Michael J Eck, C Ronald Kahn
Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with the intracellular domain of IGF1R show increased activation of Shc and Gab-1 and more potent regulation of genes involved in proliferation, corresponding to their higher mitogenic activity. Conversely, receptors with the intracellular domain of IR display higher IRS-1 phosphorylation, stronger regulation of genes in metabolic pathways and more dramatic glycolytic responses to hormonal stimulation...
March 27, 2017: Nature Communications
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