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https://www.readbyqxmd.com/read/28436380/tenofovir-disoproxil-fumarate-monotherapy-is-superior-to-entecavir-adefovir-combination-therapy-in-patients-with-suboptimal-response-to-lamivudine-adefovir-therapy-for-nucleoside-resistant-hbv-a-96-week-prospective-multicenter-trial
#1
Sae Hwan Lee, Gab Jin Cheon, Hong Soo Kim, Sang Gyune Kim, Young Seok Kim, Soung Won Jeong, Jae Young Jang, Boo Sung Kim, Baek Gyu Jun, Young Don Kim, Dae Won Jun, Joo Hyun Sohn, Tae Yeob Kim, Byung Seok Lee
BACKGROUND: A complete virologic response is closely related to the long-term outcome of patients with chronic hepatitis B and prevention of emerging hepatitis B virus (HBV) mutations. We aimed to evaluate the efficacy of tenofovir disoproxil fumarate (TDF) monotherapy compared to entecavir-adefovir dipivoxil (ETV-ADV) combination therapy in patients with suboptimal responses to long-term lamivudine-adefovir dipivoxil (LAM-ADV) therapy for nucleoside analogue-resistant chronic hepatitis B...
April 24, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28435210/incidence-of-interface-fluid-syndrome-after-laser-in-situ-keratomileusis-in-egyptian-patients
#2
Amr A Gab-Alla
PURPOSE: To determine the incidence of interface fluid syndrome (IFS) secondary to steroid-induced elevation of intraocular pressure (IOP) following laser in situ keratomileusis (LASIK) in myopic Egyptian patients. METHODS: This retrospective case series study was conducted at El-Gowhara Private Eye Center. The medical records of 1,807 patients (3,489 eyes), who underwent LASIK to correct myopia from April 2012 to December 2015 were included. The patients were operated on and reviewed by one surgeon (AAG) for IFS after LASIK associated with elevation of IOP (as compared to preoperative values)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28430745/bortezomib-pharmacokinetics-in-tumor-response-and-peripheral-neuropathy-in-multiple-myeloma-patients-receiving-bortezomib-containing-therapy
#3
Sung-Eun Lee, Kyungmee Choi, Seunghoon Han, Jongtae Lee, Taegon Hong, Gab-Jin Park, Dong-Seok Yim, Chang-Ki Min
The usefulness of pharmacokinetics of bortezomib for multiple myeloma (MM) with respect to the maximum response to bortezomib and bortezomib-induced peripheral neuropathy (BIPN) development was studied. Maximum response to subcutaneous bortezomib therapy and BIPN occurrence for the first 12 weeks of treatment in 35 MM patients treated by bortezomib-dexamethasone (VD) and bortezomib-melphalan-prednisone (VMP) were evaluated. On day 1 of cycle 1, seven whole-blood samples were collected for 3 h after dosing completion to obtain the maximum plasma concentration and area under the time-concentration curve during 3 h postdose (AUC0-3) in each patient...
April 20, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28408803/drug-drug-interaction-of-microdose-and-regular-dose-omeprazole-with-a-cyp2c19-inhibitor-and-inducer
#4
Gab-Jin Park, Soo Hyeon Bae, Wan-Su Park, Seunghoon Han, Min-Ho Park, Seok-Ho Shin, Young G Shin, Dong-Seok Yim
PURPOSE: A microdose drug-drug interaction (DDI) study may be a valuable tool for anticipating drug interaction at therapeutic doses. This study aimed to compare the magnitude of DDIs at microdoses and regular doses to explore the applicability of a microdose DDI study. PATIENTS AND METHODS: Six healthy male volunteer subjects were enrolled into each DDI study of omeprazole (victim) and known perpetrators: fluconazole (inhibitor) and rifampin (inducer). For both studies, the microdose (100 μg, cold compound) and the regular dose (20 mg) of omeprazole were given at days 0 and 1, respectively...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28404588/adaptive-functional-change-of-the-contralateral-kidney-after-partial-nephrectomy
#5
Se Young Choi, Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Partial nephrectomy aims to maintain renal function by nephron sparing; however, functional changes in the contralateral kidney remain unknown. We evaluate the functional change in the contralateral kidney using a diethylene triamine penta-acetic acid (DTPA) renal scan and determine factors predicting contralateral kidney function after partial nephrectomy. A total of 699 patients underwent partial nephrectomy, with a DTPA scan before and after surgery to assess the separate function of each kidney. Patients were divided into three groups according to initial contralateral glomerular filtration rate (GFR; group 1: <30 ml/min/1...
April 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28401380/fate-of-newly-developed-pulmonary-embolism-after-surgery-for-renal-cell-carcinoma-with-vena-cava-thrombus
#6
Sangjun Yoo, Sang Hoon Song, Heounjeong Go, Dalsan You, Cheryn Song, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn, In Gab Jeong
PURPOSE: Pulmonary embolism with viable tumor cells developed after surgery for renal cell carcinoma may metastasize to lung. We investigated the incidence and fate of newly developed pulmonary embolism after surgery for renal cell carcinoma with vena cava thrombus. METHODS: Among 4549 renal cell carcinoma patients treated with curative surgery at our institute from 1998 to 2015, 81 non-metastatic renal cell carcinoma patients with vena cava thrombus were included...
April 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28370761/preoperative-mri-features-associated-with-lymphovascular-invasion-in-node-negative-invasive-breast-cancer-a-propensity-matched-analysis
#7
Hyejin Cheon, Hye Jung Kim, So Mi Lee, Seung Hyun Cho, Kyung Min Shin, Gab Chul Kim, Ji Young Park, Won Hwa Kim
PURPOSE: In node-negative disease, the presence of lymphovascular invasion (LVI) is reported to be an unfavorable prognostic factor. Thus, the aim of this study was to evaluate whether preoperative breast MRI features are associated with LVI in patients with node-negative invasive breast cancer by a propensity-matched analysis. MATERIALS AND METHODS: Among 389 patients with node-negative invasive ductal breast cancer who had preoperative breast 3.0 Tesla MRI with precontrast T2-weighted fat-suppressed, pre- and dynamic postcontrast T1-weighted fat-suppressed sequences, 61 patients with LVI (LVI group) were matched with 183 patients without LVI (no LVI group) at a ratio of 1:3 in terms of age, histologic grade, tumor size, and hormone receptor status...
April 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28367406/cataloguing-the-bacterial-community-of-the-great-salt-plains-oklahoma-using-16s-rrna-based-metagenomics-pyrosequencing
#8
Ahmed H Gad
The Great Salt Plains of Oklahoma (GSP) is an extreme region, a hypersaline environment from marine origin and a unique area of the Salt National Wild Refuge in the north-central region of Oklahoma. In this study we analyzed the diversity and distribution of bacteria in two habitats; vegetated areas (GAB) and salt flat areas (GAS) in the sediments of GSP using the high-throughput techniques of 16S rRNA gene amplicon (V1-V2 regions) metagenomics-454 pyrosequencing. The filtered sequences resulted to a total of 303,723 paired end reads were generated, assigned into 1646 numbers of OTUs and 56...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28365982/hygroscopic-swelling-determination-of-cellulose-nanocrystal-cnc-films-by-polarized-light-microscopy-digital-image-correlation
#9
Shikha Shrestha, Jairo A Diaz, Siavash Ghanbari, Jeffrey Paul Youngblood
The coefficient of hygroscopic swelling (CHS) of self-organized and shear-oriented cellulose nanocrystal (CNC) films was determined by capturing hygroscopic strains produced as result of isothermal water vapor intake in equilibrium. Contrast enhanced microscopy digital image correlation enabled the characterization of dimensional changes induced by the hygroscopic swelling of the films. The distinct microstructure and birefringence of CNC films served in exploring the in-plane hygroscopic swelling at relative humidity values ranging from 0% to 97%...
April 3, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28365708/resistenzentwicklung-und-pr%C3%A3-diktive-marker-beim-metastasierten-prostatakarzinom
#10
Christof Bernemann, Martin Bögemann, Julie Steinestel, Andreas Jan Schrader
Anders als bei vielen anderen Krebserkrankungen gab es beim Prostatakarzinom lange Zeit keinen Ansatz für eine individualisierte Therapie. Seit der Zulassung von mehreren modernen Wirkstoffen für die Therapie des fortgeschrittenen Stadiums ändert sich dies allmählich. Zunächst galt die Androgenrezeptor-Splice-Variante AR-V7 als vielversprechender Biomarker für die Therapiesteuerung, woran sich zunehmend Zweifel mehren. Inzwischen gibt es jedoch eine Reihe von weiteren neuen, noch nicht zugelassenen und nicht (nur) auf den Androgenrezeptor fokussierenden Therapieansätzen, die auch beim fortgeschrittenen Prostatakarzinom eine personalisierte Medizin wahrscheinlicher machen...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28365706/metastasiertes-kastrationsresistentes-prostatakarzinom-grunds%C3%A3-tzliche-therapieoptionen-und-progression
#11
David Pfister
In der Entwicklung des Prostatakarzinoms spielen Androgene und der Androgenrezeptor eine zentrale Rolle. Über Jahrzehnte war die konventionelle Androgendeprivationstherapie (ADT) die wichtigste Behandlungsoption im metastasierten Stadium. Trotz initialen Ansprechens auf eine ADT entwickelt sich im Verlauf in der Regel ein metastasiertes kastrationsresistentes Prostatakarzinom (mCRPC). Für dieses Stadium gab es jahrelang keine Therapie, für die eine Verlängerung des Überlebens gezeigt werden konnte. Dies änderte sich erst 2004 mit der Studie TAX 327 zur Wirksamkeit von Docetaxel...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28351380/mirna-expression-in-the-cartilage-of-patients-with-osteoarthritis
#12
Marta Kopańska, Dariusz Szala, Joanna Czech, Natalia Gabło, Krzysztof Gargasz, Mateusz Trzeciak, Izabela Zawlik, Sławomir Snela
BACKGROUND: Osteoarthritis (OA), the most prevalent disease of articulating joints, is a complex multifactorial disease caused by genetic, mechanical, and environmental factors. In this research, we evaluated miRNA expression in OA. METHODS: Forty tissue samples from 29 patients undergoing joint replacement for OA were evaluated. Tissue from two control patients undergoing hip replacement not related to OA was used as a control. Total RNA (containing miRNA species) from cartilage was isolated using a mirVana miRNA Isolation Kit...
March 28, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28345670/domain-dependent-effects-of-insulin-and-igf-1-receptors-on-signalling-and-gene-expression
#13
Weikang Cai, Masaji Sakaguchi, Andre Kleinridders, Gonzalo Gonzalez-Del Pino, Jonathan M Dreyfuss, Brian T O'Neill, Alfred K Ramirez, Hui Pan, Jonathon N Winnay, Jeremie Boucher, Michael J Eck, C Ronald Kahn
Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with the intracellular domain of IGF1R show increased activation of Shc and Gab-1 and more potent regulation of genes involved in proliferation, corresponding to their higher mitogenic activity. Conversely, receptors with the intracellular domain of IR display higher IRS-1 phosphorylation, stronger regulation of genes in metabolic pathways and more dramatic glycolytic responses to hormonal stimulation...
March 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28331285/refraction-outcomes-after-suction-loss-during-small-incision-lenticule-extraction-smile
#14
Amr A Gab-Alla
PURPOSE: To evaluate refractive outcomes of two management approaches after suction loss during the small-incision lenticule extraction (SMILE) technique. PATIENTS AND METHODS: This retrospective and comparative study was conducted at the El-Gowhara Private Eye Center. It included 26 consecutive eyes of patients who experienced suction loss during the SMILE technique. Patients were divided into two groups by the technical difficulties in redocking: in group A (12 eyes) suction loss occurred after the posterior lenticular cut and the creation of side-cuts, then suction was reapplied, and the procedure was completed; in group B (14 eyes) suction loss occurred after the posterior lenticular cut and the creation of side-cuts, then the procedure was postponed for 24 hours and completed with the same parameters...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28329923/-actinomycosis-involving-chronic-pancreatitis-a-case-report-with-literature-review
#15
Seong Jae Yeo, Chang Min Cho, Min Kyu Jung, Ki Ju Kim, Myung Hi Kim, Seung Hyun Cho, Gab Chul Kim, An Na Seo
Actinomycosis is a slowly progressive, chronic infectious disease. It is caused by the genus Actinomyces, which are gram-positive anaerobic bacteria. It presents as a mass-like lesion, composed of bacterial nidus and characteristic granulomatous inflammatory fibrosis. As such, it has frequently been mistaken for a malignancy. Surgical resection is a common procedure in these patients prior to a definite diagnosis. Although actinomycosis can occur in a variety of regions, including oral-cervicofacial, thoracic, and abdominopelvic cavities, the involvement of the pancreas is very rare...
March 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28328820/long-term-outcomes-of-surgery-alone-versus-surgery-following-preoperative-chemoradiotherapy-for-early-t3-rectal-cancer-a-propensity-score-analysis
#16
COMPARATIVE STUDY
Seung Hyun Cho, Gyu-Seog Choi, Gab Chul Kim, An Na Seo, Hye Jung Kim, Won Hwa Kim, Kyung-Min Shin, So Mi Lee, Hunkyu Ryeom, See Hyung Kim
Recently, a few studies have raised the question of whether preoperative chemoradiotherapy (PCRT) is essential for all T3 rectal cancers. This case-matched study aimed to compare the long-term outcomes of surgery alone with those of PCRT + surgery for magnetic resonance imaging (MRI)-assessed T3ab (extramural depth of invasion ≤5 mm) and absent mesorectal fascia invasion (clear MRF) in mid/lower rectal cancer patients.From January 2006 to November 2012, 203 patients who underwent curative surgery alone (n = 118) or PCRT + surgery (n = 85) were enrolled in this retrospective study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294293/current-barriers-and-potential-strategies-to-increase-the-use-of-long-acting-reversible-contraception-larc-to-reduce-the-rate-of-unintended-pregnancies-in-australia-an-expert-roundtable-discussion
#17
Danielle Mazza, Deborah Bateson, Meredith Frearson, Philip Goldstone, Gab Kovacs, Rod Baber
BACKGROUND: Australia's abortion rates are among the highest in the developed world. Efficacy of the most commonly used form of contraception (oral contraceptives and condoms) relies on regular user compliance. Long-acting reversible contraception (LARC) virtually eradicates contraceptive failure as it is not user-dependent; however, its uptake has been low. AIM: To provide an overview of barriers to LARC use in Australia and potential strategies to overcome these barriers...
March 10, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28289665/clinical-characteristics-of-papillary-thyroid-carcinoma-arising-from-the-pyramidal-lobe
#18
Sang Gab Yoon, Jin Wook Yi, Chan-Yong Seong, Jong-Kyu Kim, Su-Jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
PURPOSE: Papillary thyroid carcinoma (PTC) arising from the pyramidal lobe is rare; therefore, clinicopathologic evaluation is lacking. In addition, the rate of occult malignancy in the pyramidal lobe after thyroid surgery is unclear. This study is to evaluate the clinical characteristics of PTCs that involve the pyramidal lobe. METHODS: The study enrolled 1,107 patients who underwent thyroid surgery for PTC at Seoul National University Hospital from 2006 to 2015...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28285514/fasciola-hepatica-infection-status-of-freshwater-snails-collected-from-gangwon-do-province-korea
#19
Jae-Hyung Lee, Juan-Hua Quan, In-Wook Choi, Gab-Man Park, Guang-Ho Cha, Hyun-Ju Kim, Jae-Min Yuk, Young-Ha Lee
Fasciola hepatica is a trematode that causes zoonosis, mainly in cattle and sheep, and occasionally in humans. Few recent studies have determined the infection status of this fluke in Korea. In August 2015, we collected 402 samples of freshwater snails at Hoenggye-ri (upper stream) and Suha-ri (lower stream) of Song-cheon (stream) in Daegwalnyeong-myeon, Pyeongchang-gun in Gangwon-do (Province) near many large cattle or sheep farms. F. hepatica infection was determined using PCR on the nuclear ribosomal internal transcribed spacer 2 (ITS-2)...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28283911/recovery-of-renal-function-after-administration-of-adipose-tissue-derived-stromal-vascular-fraction-in-rat-model-of-acute-kidney-injury-induced-by-ischemia-reperfusion-injury
#20
Chunwoo Lee, Myoung Jin Jang, Bo Hyun Kim, Jin Young Park, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim
Acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) injury is a major challenge in critical care medicine. The purpose of this study is to determine the therapeutic effects of the adipose-tissue-derived stromal vascular fraction (SVF) and the optimal route for SVF delivery in a rat model of AKI induced by I/R injury. Fifty male Sprague-Dawley rats were randomly divided into five groups (10 animals per group): sham, nephrectomy control, I/R injury control, renal arterial SVF infusion and subcapsular SVF injection...
March 10, 2017: Cell and Tissue Research
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