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https://www.readbyqxmd.com/read/28932091/randomized-clinical-trial-comparing-fixed-time-split-dosing-and-split-dosing-of-oral-picosulfate-regimen-for-bowel-preparation
#1
Jae Hyuck Jun, Koon Hee Han, Jong Kyu Park, Hyun Il Seo, Young Don Kim, Sang Jin Lee, Baek Gyu Jun, Min Sik Hwang, Yoon Kyoo Park, Myeong Jong Kim, Gab Jin Cheon
AIM: To compare the efficacy of fixed-time split dose and split dose of an oral sodium picosulfate for bowel preparation. METHODS: This is study was prospective, randomized controlled study performed at a single Institution (2013-058). A total of 204 subjects were assigned to receive one of two sodium picosulfate regimens (i.e., fixed-time split or split) prior to colonoscopy. Main outcome measurements were bowel preparation quality and subject tolerability. RESULTS: There was no statistical difference between the fixed-time split dose regimen group and the split dose regimen group (Ottawa score mean 2...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28901666/clinicopathological-and-molecular-characteristics-of-pediatric-meningiomas
#2
Sudha Battu, Anupam Kumar, Pankaj Pathak, Suvendu Purkait, Linchi Dhawan, Mehar C Sharma, Ashish Suri, Manmohan Singh, Chitra Sarkar, Vaishali Suri
Molecular and clinical characteristics of pediatric meningiomas are poorly defined. Therefore, we analyzed clinical, morphological and molecular profiles of pediatric meningiomas. Forty pediatric meningiomas from January 2002 to June 2015 were studied. 1p36, 14q32 and 22q-deletion were assessed by fluorescent in situ hybridization and mutations of most relevant exons of AKT, SMO, KLF4, TRAF and pTERT using sequencing. Expression of GAB1, stathmin, progesterone receptor (PR), p53 along with MIB-1 LI was examined using immunohistochemistry...
September 13, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28889920/the-incidence-of-unsuccessful-partial-nephrectomy-within-the-united-states-a-nationwide-population-based-analysis-from-2003-to-2015
#3
Yash S Khandwala, In Gab Jeong, Jae Heon Kim, Deok Hyun Han, Shufeng Li, Ye Wang, Steven L Chang, Benjamin I Chung
PURPOSE: Partial nephrectomy (PN) remains underutilized within the United States and few reports have attempted to explain this trend. The aim of this study is to evaluate the nationwide incidence of unsuccessful PN and factors that predict its occurrence. METHODS: Using the Premier Healthcare Database, we retrospectively analyzed a weighted sample of 66,432 patients undergoing curative surgery for renal mass between 2003 and 2015. PN intent was denoted by presence of insurance claims for the administration of mannitol...
September 7, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28873728/development-and-characterization-of-a-new-encapsulating-agent-from-orange-juice-by-products
#4
Kyriakos Kaderides, Athanasia M Goula
The replacement of maltodextrins as carriers for the spray drying of sticky and sugar based bioactives is an important development for the food industry. In this work, orange juice industry by-product was used to obtain a high dietary fiber powder to be used as carrier material. This powder was characterized with respect to its physical and chemical properties related to the process of encapsulation by spray drying. Adsorption isotherms of orange waste powder were determined at 30, 45, and 60°C. The data were fitted to several models including two-parameter (BET, Halsey, Smith, and Oswin), three-parameter (GAB), and four-parameter (Peleg) relationships...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28852937/surgeon-preference-of-surgical-approach-for-partial-nephrectomy-in-patients-with-baseline-chronic-kidney-disease-a-nationwide-population-based-analysis-in-the-usa
#5
Yash S Khandwala, In Gab Jeong, Deok Hyun Han, Jae Heon Kim, Shufeng Li, Ye Wang, Steven L Chang, Benjamin I Chung
PURPOSE: To examine trends in utilization of open, laparoscopic and robot-assisted surgical approaches for treatment of patients with chronic kidney disease (CKD) undergoing partial nephrectomy (PN) within the USA. METHODS: We analyzed a weighted sample of 112,117 patients from the Premier administrative dataset who underwent PN for renal mass between 2003 and 2015. Proportions of surgical approach utilization were evaluated by CKD status and further stratified by surgery year and surgeon volume...
August 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28851870/sde5-a-putative-rna-export-protein-participates-in-plant-innate-immunity-through-a-flagellin-dependent-signaling-pathway-in-arabidopsis
#6
Mohammad Nazim Uddin, Salina Akhter, Rupak Chakraborty, Ji Hyeong Baek, Joon-Yung Cha, Su Jung Park, Hunseung Kang, Woe-Yeon Kim, Sang Yeol Lee, David Mackey, Min Gab Kim
In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread and versatile silencing mechanism that plays an important role in various biological processes. Increasing evidences suggest that various components of RNA silencing pathway are involved in plant defense machinery against microbial pathogens in Arabidopsis thaliana. Here, we show genetic and molecular evidence that Arabidopsis SDE5 is required to generate an effective resistance against the biotrophic bacteria Pseudomonas syringae pv...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845774/a-validated-reverse-phase-hplc-method-for-quantitative-determination-of-ganoderic-acids-a-and-b-in-cultivated-strains-of-ganoderma-spp-agaricomycetes-indigenous-to-india
#7
M Ramakrishna, D Rajesh Babu, S S Veena, Meera Pandey, Nageswara Rao
Twenty isolates of Ganoderma spp. indigenous to India were used in this study. A reverse-phase high-performance liquid chromatography (HPLC) method was used to quantify 2 of the most bioactive triterpenes, ganoderic acid A (GAA) and ganoderic acid B (GAB), among the cultivated Ganoderma spp. The HPLC analysis was performed on an Agilent 1260 Infinity HPLC system with a Zorbax C18 column, using gradient elution of acetonitrile and 0.1% acetic acid. The detection wavelength was set at 254 nm, with a flow rate of 0...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28844122/clinical-significance-of-radiation-induced-liver-disease-after-stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma
#8
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD. Methods: We retrospectively reviewed the medical records of 117 HCC patients who were treated by SBRT from March 2011 to February 2015. RILD was defined as elevated liver transaminases more than five times the upper normal limit or a worsening of Child-Pugh (CP) score by 2 within 3 months after SBRT...
August 28, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28830644/ultrasound-guided-fine-needle-aspiration-of-non-palpable-and-suspicious-axillary-lymph-nodes-with-subsequent-removal-after-tattooing-false-negative-results-and-concordance-with-sentinel-lymph-nodes
#9
Won Hwa Kim, Hye Jung Kim, Jin Hyang Jung, Ho Yong Park, Jeeyeon Lee, Wan Wook Kim, Ji Young Park, Hyejin Cheon, So Mi Lee, Seung Hyun Cho, Kyung Min Shin, Gab Chul Kim
Ultrasonography-guided fine-needle aspiration (US-guided FNA) for axillary lymph nodes (ALNs) is currently used with various techniques for the initial staging of breast cancer and tagging of ALNs. With the implementation of the tattooing of biopsied ALNs, the rate of false-negative results of US-guided FNA for non-palpable and suspicious ALNs and concordance with sentinel lymph nodes were determined by node-to node analyses. A total of 61 patients with breast cancer had negative results for metastasis on US-guided FNA of their non-palpable and suspicious ALNs...
August 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28821046/water-sorption-in-microfibrillated-cellulose-mfc-the-effect-of-temperature-and-pretreatment
#10
Çağlar Meriçer, Matteo Minelli, Marco Giacinti Baschetti, Tom Lindström
Water sorption behavior of two different microfibrillated cellulose (MFC) films, produced by delamination of cellulose pulp after different pretreatment methods, is examined at various temperatures (16-65°C) and up to 70% RH. The effect of drying temperature of MFC films on the water uptake is also investigated. The obtained solubility isotherms showed the typical downward curvature at moderate RH, while no upturn is observed at higher RH; the uptakes are in line with characteristic values for cellulose fibers...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28818535/use-of-the-ileum-for-ureteral-stricture-and-obstruction-in-bilateral-unilateral-and-single-kidney-cases
#11
Aram Kim, Wook Nam, Sang Hoon Song, In Gab Jeong, Bumsik Hong
Objectives To investigate the functional outcomes of ileal ureter replacement for complex ureteral loss, including bilateral and single ureter stricture, as a result of various etiologies. Methods In 2013-2016, 31 patients underwent ileal ureter replacement surgery. The data for their assessments included etiology, combined surgical procedures, ureteral replacement type, postoperative complications, and changes in renal function. Results The 31 study patients had a median age of 56.0 (range 18 to 65) years old and were followed for a median 23...
August 14, 2017: Urology
https://www.readbyqxmd.com/read/28769977/predisposing-factors-of-ischemic-colitis-data-from-14-years-of-experience-in-a-single-center
#12
Hyun Il Seo, Kyoo-Ho Choi, Koon Hee Han, Sang Jin Lee, Jong Kyu Park, Young Don Kim, Gab Jin Cheon
BACKGROUND AND AIMS: While several case reports on ischemic colitis (IC) suggest the presence of predisposing causative factors, a few studies have investigated the predisposing factors in IC. This study aimed to identify the characteristics of patients with IC, particularly focusing on the predisposing factors. METHODS: We conducted a single-center, retrospective analysis of 159 patients with IC. Clinical characteristics, laboratory data, endoscopic findings, and medical records were reviewed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28720331/a-novel-antihypertension-agent-sargachromenol-d-from-marine-brown-algae-sargassum-siliquastrum-exerts-dual-action-as-an-l-type-ca-2-channel-blocker-and-endothelin-a-b2-receptor-antagonist
#13
Byong-Gon Park, Woon-Seob Shin, Sangtae Oh, Gab-Man Park, Nam Ik Kim, Seokjoon Lee
We isolated the novel vasoactive marine natural products, (5E,10E)-14-hydroxy-2,6,10-trimethylpentadeca-5,10-dien-4-one (4) and sargachromenol D (5), from Sargassum siliquastrum collected from the coast of the East Sea in South Korea by using activity-guided HPLC purification. The compounds effectively dilated depolarization (50mMK(+))-induced basilar artery contraction with EC50 values of 3.52±0.42 and 1.62±0.63μM, respectively, but only sargachromenol D (5) showed a vasodilatory effect on endothelin-1 (ET-1)-induced basilar artery contraction (EC50=9...
July 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28704981/corrosion-resistance-of-nanopowders-of-borides-and-carbides-of-iv-vib-group-metals-in-the-nickeling-electrolytes
#14
Dmytro Shakhnin, Viktor Malyshev, Nina Kuschevskaya, Angelina Gab
The corrosion resistance of nanopowders of borides and carbides of metals of IV-VIB groups, as well as of silicon carbide, was studied in the standard nickeling electrolytes. As objects of study, nanopowders with the content of the main phase 91.8-97.6% and with the average particle size 32-78 nm were used. Their corrosion resistance was evaluated depending on the acidity of the electrolyte, temperature, and duration of the interaction. It was found that, by the corrosion resistance in the electrolytes solutions, nanopowders of borides and carbides within each group of compounds are similar and characterized by unlimited period of induction in alkaline media...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28703915/self-normalized-detection-of-anxa3-from-untreated-urine-of-prostate-cancer-patients-without-digital-rectal-examination
#15
Minhong Jeun, Sungwook Park, Yongdeok Kim, Jaewon Choi, Sang Hoon Song, In Gab Jeong, Choung-Soo Kim, Kwan Hyi Lee
A noninvasive quantitative assay that is capable of identifying prostate cancer biomarkers in untreated urine is an attractive diagnosis tool, but this method is subject to various obstacles. Difficulties presented by untreated urine include varying salt concentrations, and pH levels that may be different even though they are from the same patient. Untreated urine also presents interference from other biomolecules and possesses a fewer number of cancer biomarkers than can be found in serum. As a result, urine preconditioning processes and digital rectal examination (DRE) to increase biomarker secretion are mandatory in current urine assays...
September 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28687632/increased-levels-of-gab1-and-gab2-adaptor-proteins-skew-interleukin-4-il-4-signaling-toward-m2-macrophage-driven-pulmonary-fibrosis-in-mice
#16
Xiaohong Guo, Tingting Li, Yun Xu, Xiayan Xu, Zhengyi Zhu, Yun Zhang, Jiaqi Xu, Kaihong Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke
M2-polarized macrophages, also known as alternatively activated macrophages, have long been associated with pulmonary fibrosis; however, the mechanism has not been fully defined. Gab1 and Gab2 proteins belong to the Gab family of adaptors and are integral components of the signal specificity in response to various extracellular stimuli. In this report, we found that levels of both Gab1 and Gab2 were elevated in M2-polarized macrophages isolated from bleomycin-induced fibrotic lungs. In vitro Gab1/2 deficiency in bone marrow-derived macrophages abrogated IL-4-mediated M2 polarization...
August 25, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28676956/roux-en-y-gastric-bypass-aggravates-vitamin-a-deficiency-in-the-mother-child-group
#17
Sabrina Pereira da Cruz, Andréa Matos, Silvia Pereira, Carlos Saboya, Suelem Pereira da Cruz, Andréa Ramalho
OBJECTIVE: The objectives of this study are to compare the nutritional status of vitamin A in women who previously underwent Roux-en-Y gastric bypass (RYGB) who became pregnant or did not, in the same period after surgery, and to assess its effects on mother and child health. METHODOLOGY: A retrospective longitudinal study conducted with women who previously underwent RYGB, paired by age and BMI measured before surgery, divided into group 1 (G1) comprising 77 women who did not become pregnant and group 2 (G2) with 39 women in their third gestational trimester...
July 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28667124/distinct-vasp-tetramers-synergize-in-the-processive-elongation-of-individual-actin-filaments-from-clustered-arrays
#18
Stefan Brühmann, Dmitry S Ushakov, Moritz Winterhoff, Richard B Dickinson, Ute Curth, Jan Faix
Ena/VASP proteins act as actin polymerases that drive the processive elongation of filament barbed ends in membrane protrusions or at the surface of bacterial pathogens. Based on previous analyses of fast and slow elongating VASP proteins by in vitro total internal reflection fluorescence microscopy (TIRFM) and kinetic and thermodynamic measurements, we established a kinetic model of Ena/VASP-mediated actin filament elongation. At steady state, it entails that tetrameric VASP uses one of its arms to processively track growing filament barbed ends while three G-actin-binding sites (GABs) on other arms are available to recruit and deliver monomers to the filament tip, suggesting that VASP operates as a single tetramer in solution or when clustered on a surface, albeit processivity and resistance toward capping protein (CP) differ dramatically between both conditions...
July 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28660432/human-microdosing-and-mice-xenograft-data-of-agm-130-applied-to-estimate-efficacious-doses-in-patients
#19
Wan-Su Park, Gab-Jin Park, Seunghoon Han, Sooho Ban, Moon-Young Park, San-Ho Kim, Seon-Myung Kim, Yong-Chul Kim, Hyung Sik Kim, Young G Shin, Dong-Seok Yim
PURPOSE: AGM-130 is a cyclin-dependent kinase inhibitor that exhibits dose-dependent efficacy in xenograft mouse models. During preclinical pharmacokinetic (PK) studies, mice and rats showed comparable PK parameters while dogs showed unusually high clearance (CL), which has made human PK prediction challenging. To address this discrepancy, we performed a human microdosing PK and developed a mouse PK/PD model in order to guide the first-in-human studies. METHODS: A microdose of AGM-130 was given via intravenous injection to healthy subjects...
August 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28652921/comparison-of-facet-joint-degeneration-in-firefighters-and-hospital-office-workers
#20
Dong Hyun Kim, Yon Soo An, Hyung Doo Kim, Kyoung Sook Jeong, Yeon-Soon Ahn, Kun-Hyung Kim, Youngki Kim, Han-Soo Song, Chul-Gab Lee, Young-Jun Kwon, Jin-Ha Yoon
BACKGROUND: There are few published studies on the relationship between occupational lumbar load and facet joint degeneration (FJD). This cross-sectional study was conducted to evaluate the effect of physical lumbar load on FJD by comparing magnetic resonance imaging (MRI) findings of firefighters (FFs) and hospital office workers (HOWs). METHODS: We randomly sampled 341 male FFs and 80 male HOWs by age stratification. A questionnaire and clinical examination, including MRI of the lumbar spine (T12-S1), were conducted...
2017: Annals of Occupational and Environmental Medicine
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