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Interferon gamma polymorphism

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https://www.readbyqxmd.com/read/28506689/genetic-factors-interact-with-tobacco-smoke-to-modify-risk-for-inflammatory-bowel-disease-in-humans-and-mice
#1
Pankaj Yadav, David Ellinghaus, Gaëlle Rémy, Sandra Freitag-Wolf, Anabelle Cesaro, Frauke Degenhardt, Gabrielle Boucher, Myriam Delacre, Laurent Peyrin-Biroulet, Muriel Pichavant, John D Rioux, Philippe Gosset, Andre Franke, L Philip Schumm, Michael Krawczak, Mathias Chamaillard, Astrid Dempfle, Vibeke Andersen
BACKGROUND & AIMS: The role of tobacco smoke in the etiology of inflammatory bowel disease (IBD) is unclear. We investigated interactions between genes and smoking (gene-smoking interactions) that affect risk for Crohn's disease (CD) and ulcerative colitis (UC) in a case-only study of patients and in mouse models of IBD. METHODS: We used 55 immunochip-wide data sets that included 19,735 IBD cases (10,856 CD cases and 8879 UC cases) of known smoking status. We performed 3 meta-analyses each for CD, UC, and IBD (CD and UC combined), comparing data for never vs ever smokers, never vs current smokers, and never vs former smokers...
May 12, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28499279/a-single-nucleotide-polymorphism-in-the-interferon-%C3%AE-gene-ifng-874-t-a-is-associated-with-susceptibility-to-tuberculosis
#2
Zhang Wei, Shen Wenhao, Mi Yuanyuan, Li Yang, Daming Zhou, Xian Jiangchun, Jiang Jijun
Interferon-γ (Interferon gamma, IFNG) is an important cytokine involved in providing resistance to mycobacterial diseases. Common variants of IFNG, such as IFNG +874 T/A(rs2430561), may be related to tuberculosis susceptibility, but this association has not been consistently observed. We performed an updated meta-analysis to evaluate the association between the IFNG +874 T/A (rs2430561) polymorphism and tuberculosis susceptibility. PubMed and SinoMed databases were searched up to October 2016, and odds ratios (OR) and 95% confidence intervals (CI) were used to assess the association strength...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28400196/association-of-rnaset2-gene-polymorphisms-with-decreased-expression-and-clinical-characteristics-of-severity-in-crohn-s-disease
#3
Rivkah Gonsky, Phillip Fleshner, Richard L Deem, Eva Biener-Ramanujan, Dalin Li, Alka A Potdar, Janine Bilsborough, Shaohong Yang, Dermot P B McGovern, Stephan R Targan
BACKGROUND & AIMS: Variants in the tumor necrosis factor superfamily member 15 gene (TNFSF15, also called TL1A) have been associated with risk for inflammatory bowel diseases (IBD). TL1A affects expression of multiple cytokines to promote mucosal inflammation. Little is known about the TL1A-response pathways that regulate cytokine expression. We investigated T-cell gene expression patterns to determine the mechanisms by which TL1A regulates cytokine production, and whether these associate with outcomes of patients with Crohn's disease (CD)...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28387608/common-polymorphisms-in-the-ifi16-and-aim2-genes-are-associated-with-periodontal-disease
#4
Julie T Marchesan, Yizu Jiao, Kevin Moss, Kimon Divaris, William Seaman, Jennifer Webster-Cyriaque, Shaoping Zhang, Ning Yu, Catharine Song, Sompop Bencharit, Ricardo Teles, Steven Offenbacher
BACKGROUND: We investigated the single nucleotide polymorphism (SNP) context of a previously identified periodontitis-associated locus and examined its association with microbial, biological and periodontal disease clinical parameters. METHODS: We annotated a 200Kb-spanning region of 1q12 previously highlighted in a genome-wide association scan among 4,910 European American individuals (SNP rs1633266). Two haplotype blocks were selected. We examined the association of these polymorphisms with data on microbial plaque composition, gingival crevicular fluid (GCF)-interleukin (IL)-1β levels and clinical parameters of periodontal disease...
April 7, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28387594/interleukin-10-and-interferon-gamma-gene-polymorphisms-and-hepatitis-c-virus-related-liver-cirrhosis-risk
#5
Abeer Sheneef, Mamdouh M Esmat, Asmaa N Mohammad, Aida A Mahmoud, Hoda M Moghazy, Amal K Noureldin
The aim of the study was to evaluate the association between the gene polymorphisms in interleukin-10 (IL-10) and interferon gamma (IFN-γ) genes with susceptibility and severity of hepatitis C virus (HCV) infection among Egyptian patients. Interleukin-10 -592 A/C, -1082 G/A and IFN-γ +874 T/A genotypes were determined in 100 chronic HCV patients and 50 healthy controls using restriction fragment length polymorphism (RFLP) and the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) respectively...
April 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28378632/note-of-clarification-of-data-in-the-paper-entitled-interferon-gamma-874-t-a-polymorphism-increases-the-risk-of-cervical-cancer-evidence-from-a-meta-analysis
#6
Haijun Yang, Min Yang, Yan Wang, Xing Huang
We read with great interest the paper entitled "Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis" published online by Sun et al. Their results suggest that interferon gamma ( IFNG) gene +874 T/A polymorphism might contribute to women's susceptibility to cervical cancer. They also found that IFNG +874 T/A polymorphism is associated with increased cervical cancer risk in Asian female population. The result is encouraging. Nevertheless, several key issues are worth noticing...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28366330/cytokine-polymorphisms-are-associated-with-daytime-napping-in-adults-living-with-hiv
#7
Eeeseung Byun, Caryl L Gay, Carmen J Portillo, Clive R Pullinger, Bradley E Aouizerat, Kathryn A Lee
OBJECTIVE/BACKGROUND: Daytime napping longer than one hour has been associated with an increased risk for all-cause mortality. Associations between cytokine polymorphisms and daytime napping in chronic illnesses such as HIV, however, have not been well described. The purpose of this study was to examine cytokine polymorphisms associated with long daytime napping in adults living with HIV. METHODS: A cross-sectional analysis was conducted using a convenience sample of 257 adults living with HIV...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28332776/interferon-gamma-and-interleukin-10-polymorphisms-in-chinese-children-with-hemophagocytic-lymphohistiocytosis
#8
Qi An, Shao-Yan Hu, Cheng-Min Xuan, Ming-Wei Jin, Qiang Ji, Yi Wang
AIM: The aim of the study is to investigate the association of interferon gamma (IFN-γ) and interleukin-10 (IL-10) gene single nucleotide polymorphisms with the susceptibility of hemophagocytic lymphohistiocytosis (HLH) in Chinese children without known family history of HLH. PROCEDURE: Forty children with HLH and 160 age- and gender-matched healthy controls from Xuzhou Children's Hospital were enrolled in the study. Serum IFN-γ and IL-10 levels were measured by enzyme linked-immunosorbent assay...
March 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28139755/genetically-determined-high-activity-of-il-12-and-il-18-in-ulcerative-colitis-and-tlr5-in-crohns-disease-were-associated-with-non-response-to-anti-tnf-therapy
#9
S Bank, P S Andersen, J Burisch, N Pedersen, S Roug, J Galsgaard, S Y Turino, J B Brodersen, S Rashid, B K Rasmussen, S Avlund, T B Olesen, H J Hoffmann, B A Nexø, J Sode, U Vogel, V Andersen
Anti-tumour necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. A recent study indicated that genetically determined high activity of pro-inflammatory cytokines, including interleukin-1β (IL-1β), IL-6 and interferon gamma (IFN-γ), are associated with non-response to anti-TNF therapy. Using a candidate gene approach, 21 functional single-nucleotide polymorphisms (SNPs) in 14 genes in the Toll-like receptors, the inflammasome and the IFNG pathways were assessed in 482 and 256 prior anti-TNF naïve Danish patients with CD and UC, respectively...
January 31, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28043560/the-importance-of-single-nucleotide-polymorphisms-in-interferon-gamma-receptor-1-gene-in-pulmonary-patients-infected-with-rapid-grower-mycobacterium
#10
Poopak Farnia, Jalaledin Ghanavi, Payam Tabasri, Shima Saif, Ali Akbar Velayati
OBJECTIVE/BACKGROUND: Interferon gamma (IFN-γ) plays a key role in protective immune response against Mycobacterial infection. IFN-γ excretes its antimycobacterial effectors mechanisms by activation of macrophages and dendritic cells via interaction with its receptor complex, that is, a ligand-binding subunit [IFN-γ receptor (IFNGR)1] and an accessory subunit (IFNGR2) on the cell surface. It has been shown that individuals with complete or partial IFNGR1 receptor deficiency are highly susceptible to infection by nontuberculous mycobacteria (NTM), Mycobacterium tuberculosis, and some Salmonella species...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28000585/ifn-%C3%AE-promoter-polymorphisms-do-not-affect-quantiferon%C3%A2-tb-gold-in-tube-test-results-in-a-canadian-population
#11
S Kiazyk, L Larcombe, C Lopez, S Matyas, C Mesa, P Orr, J Juno, J Waruk, M Sharma, T B Ball
BACKGROUND: Several studies have shown polymorphisms within the interferon-gamma (IFN-γ) promoter influence cytokine expression. The interferon-gamma release assay (IGRA) relies on the ability to produce IFN-γ in response to tuberculosis (TB) specific antigens. This study determined the relationship between the IFN-γ +874 A/T promoter polymorphism and the performance of the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test in an ethnically diverse Canadian population. METHODS: A total of 190 participants were categorised into three groups based on history of and exposure to TB: active TB (n = 55), TB exposed (n = 55) and presumably TB unexposed controls (n = 80)...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931341/ifn-promoter-polymorphisms-do-not-affect-quantiferon-tb-gold-in-tube-test-results-in-a-canadian-population
#12
S Kiazyk, L Larcombe, C Lopez, S Matyas, C Mesa, P Orr, J Juno, J Waruk, M Sharma, T B Ball
BACKGROUND: Several studies have shown polymorphisms within the interferon-gamma (IFN-) promoter influence cytokine expression. The interferon-gamma release assay (IGRA) relies on the ability to produce IFN- in response to tuberculosis (TB) specific antigens. This study determined the relationship between the IFN- +874 A/T promoter polymorphism and the performance of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test in an ethnically diverse Canadian population. METHODS: A total of 190 participants were categorised into three groups based on history of and exposure to TB: active TB (n = 55), TB exposed (n = 55) and presumably TB unexposed controls (n = 80)...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27800132/interferon-gamma-gene-polymorphism-874-t-a-and-chronic-hepatitis-b-in-the-population-of-gorgan-north-eastern-iran
#13
Nadia Ghasemian, Majid Shahbazi
BACKGROUND: Based on differences in individual immune responses to the hepatitis B virus (HBV), between 5% and 10% of patients become persistently infected with the virus, which leads to the determination of chronic HBV. Cytokines such as interferon gamma (IFN-γ) are secretory proteins that play important roles in both innate and adaptive immune responses. Functional studies have demonstrated that the IFN + 874A/T gene polymorphism can increase or decrease the overall expression of IFN-gamma (γ) and ultimately determine the outcome of the infection...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27756230/circulating-granulysin-levels-in-healthcare-workers-and-latent-tuberculosis-infection-estimated-using-interferon-gamma-release-assays
#14
Pham Huu Thuong, Do Bang Tam, Shinsaku Sakurada, Nguyen Thi Le Hang, Minako Hijikata, Le Thi Hong, Phan Thi Minh Ngoc, Pham Thu Anh, Vu Cao Cuong, Ikumi Matsushita, Luu Thi Lien, Naoto Keicho
BACKGROUND: Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tuberculosis (TB) infection. METHODS: Latency of TB infection among Vietnamese healthcare workers was estimated using interferon-gamma release assays (IGRA), and serum GNLY concentrations were measured using enzyme-linked immunosorbent assays. The levels of GNLY expression in whole blood and the presence of GNLY alleles with the exon-4 polymorphism rs11127 were also determined using PCR-based methods...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27755461/association-of-mbl2-tlr1-tlr2-and-tlr6-polymorphisms-with-production-of-ifn-%C3%AE-and-il-12-in-bcg-osteitis-survivors-r1
#15
Laura Pöyhönen, Liisa Kröger, Heini Huhtala, Johanna Mäkinen, Kirsi Nuolivirta, Jussi Mertsola, Qiushui He, Matti Korppi
BACKGROUND: Interferon-gamma (IFN-γ) is a key cytokine in defense against mycobacteria, including Bacillus Calmette-Guérin (BCG). Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are pattern-recognizing molecules of innate immunity. The aim of the present study was to investigate the relationship between polymorphisms in MBL, TLR1, TLR2 and TLR6 encoding genes and stimulated IFN-γ and interleukin-12 (IL-12) ex vivo production in BCG osteitis survivors. METHODS: Data on single nucleotide polymorphisms in the MBL2 gene and TLR1, TLR2 and TLR6 genes were available from 132 former BCG osteitis patients, and data on ex vivo IFN-γ and IL-12 production were available from 115 and 118 patients, respectively...
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27695641/cell-intrinsic-factors-modulate-the-effects-of-ifn%C3%AE-on-the-development-of-chlamydia-trachomatis
#16
Shardulendra Sherchand, Joyce A Ibana, Alison J Quayle, Ashok Aiyar
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that cannot synthesize several amino acids, including tryptophan. Rather, C. trachomatis acquires these essential metabolites from its human host cell. Chlamydial dependence on host-provided tryptophan underlies a major host defense mechanism against the bacterium; namely, the induction of the host tryptophan-catabolizing enzyme, indoleamine 2,3- dioxygenase (IDO1) by interferon gamma (IFNγ), which leads to eradication of C. trachomatis by tryptophan starvation...
August 2016: Journal of Bacteriology & Parasitology
https://www.readbyqxmd.com/read/27622767/pathway-analysis-incorporating-protein-protein-interaction-networks-identified-candidate-pathways-for-the-seven-common-diseases
#17
Peng-Lin Lin, Ya-Wen Yu, Ren-Hua Chung
Pathway analysis has become popular as a secondary analysis strategy for genome-wide association studies (GWAS). Most of the current pathway analysis methods aggregate signals from the main effects of single nucleotide polymorphisms (SNPs) in genes within a pathway without considering the effects of gene-gene interactions. However, gene-gene interactions can also have critical effects on complex diseases. Protein-protein interaction (PPI) networks have been used to define gene pairs for the gene-gene interaction tests...
2016: PloS One
https://www.readbyqxmd.com/read/27563937/ifngr2-genetic-polymorphism-associated-with-sex-specific-paranoid-schizophrenia-risk
#18
Achraf Jemli, Oumaima Inoubli, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad
BACKGROUND: Considering current scientific evidence about the significant role of chronic low grade inflammation in the physiopathology of schizophrenia, it has been hypothesized that changes in pro-inflammatory cytokines such as interferon gamma may have a significant role in the predisposition to schizophrenia. AIM: This study focuses on identifying whether the functional polymorphism of interferon gamma receptor 2 (IFNGR2) is a risk factor for the development of schizophrenia...
January 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27544215/association-of-genetic-polymorphisms-in-interferon-%C3%AE-interleukin-6-and-transforming-growth-factor-%C3%AE-1-gene-with-oral-lichen-planus-susceptibility
#19
Maha Ali M Al-Mohaya, Lubna Al-Otaibi, Fahad Al-Harthi, Ebtissam Al Bakr, Misbahul Arfin, Abdulrahman Al-Asmari
BACKGROUND: Oral lichen planus (OLP) is a premalignant mucocutaneous disease in which genetic factors and immune responses play a major role. Cytokines play an important role in the pathogenesis and disease progression of OLP. The aim of this study was to investigate the impact of gene polymorphisms of T helper cell subtype Th1 and Th2 cytokines, interferon-gamma (IFN-γ), interleukin-6 (IL-6) and transforming growth factor (TGF)-β1 on OLP susceptibility in a Saudi cohort. METHODS: Forty two unrelated patients with OLP and 195 healthy controls were genotyped for IFN-γ (874A/T), IL-6 (174G/C) and TGF-β1 (509C/T) polymorphisms...
2016: BMC Oral Health
https://www.readbyqxmd.com/read/27521485/high-levels-of-plasma-interferon-gamma-and-874t-a-gene-polymorphism-is-associated-with-hiv-tb-co-infection
#20
V R Gutlapalli, Aparna Sykam, Sandeep P Tenali, Sujai Suneetha, Lavanya M Suneetha
OBJECTIVE: Tuberculosis (TB) is one of the most frequent opportunistic infections in HIV patients leading to increased morbidity and death rate. This study was carried out to investigate the role of the cytokines IFN-γ and TNF-α level and their single nucleotide polymorphisms (SNPs) in HIV-TB co-infection. METHODS: 247 HIV-TB (124 HIV-pulmonary TB, 123 HIV-extra pulmonary TB), 126 HIV positive individuals without tuberculosis and 129 healthy subjects (HS) were included to measure plasma levels of IFN-γ and TNF-α by sandwich ELISA and One way ANOVA statistical analysis was carried out among the groups...
December 2016: Human Immunology
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