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Interferon gamma polymorphism

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https://www.readbyqxmd.com/read/27800132/interferon-gamma-gene-polymorphism-874-t-a-and-chronic-hepatitis-b-in-the-population-of-gorgan-north-eastern-iran
#1
Nadia Ghasemian, Majid Shahbazi
BACKGROUND: Based on differences in individual immune responses to the hepatitis B virus (HBV), between 5% and 10% of patients become persistently infected with the virus, which leads to the determination of chronic HBV. Cytokines such as interferon gamma (IFN-γ) are secretory proteins that play important roles in both innate and adaptive immune responses. Functional studies have demonstrated that the IFN + 874A/T gene polymorphism can increase or decrease the overall expression of IFN-gamma (γ) and ultimately determine the outcome of the infection...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27756230/circulating-granulysin-levels-in-healthcare-workers-and-latent-tuberculosis-infection-estimated-using-interferon-gamma-release-assays
#2
Pham Huu Thuong, Do Bang Tam, Shinsaku Sakurada, Nguyen Thi Le Hang, Minako Hijikata, Le Thi Hong, Phan Thi Minh Ngoc, Pham Thu Anh, Vu Cao Cuong, Ikumi Matsushita, Luu Thi Lien, Naoto Keicho
BACKGROUND: Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tuberculosis (TB) infection. METHODS: Latency of TB infection among Vietnamese healthcare workers was estimated using interferon-gamma release assays (IGRA), and serum GNLY concentrations were measured using enzyme-linked immunosorbent assays. The levels of GNLY expression in whole blood and the presence of GNLY alleles with the exon-4 polymorphism rs11127 were also determined using PCR-based methods...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27755461/association-of-mbl2-tlr1-tlr2-and-tlr6-polymorphisms-with-production-of-ifn-%C3%AE-and-il-12-in-bcg-osteitis-survivors
#3
Laura Pöyhönen, Liisa Kröger, Heini Huhtala, Johanna Mäkinen, Kirsi Nuolivirta, Jussi Mertsola, Qiushui He, Matti Korppi
BACKGROUND: Interferon-gamma (IFN-γ) is a key cytokine in defense against mycobacteria, including Bacillus Calmette-Guérin (BCG). Mannose-binding lectin (MBL) and Toll-like receptors (TLRs) are pattern-recognizing molecules of innate immunity. The aim of the present study was to investigate the relationship between polymorphisms in MBL, TLR1, TLR2, and TLR6 encoding genes and stimulated IFN-γ and interleukin-12 (IL-12) ex vivo production in BCG osteitis survivors. METHODS: Data on single nucleotide polymorphisms (SNPs) in the MBL2 gene and TLR1, TLR2, and TLR6 genes were available from 132 former BCG osteitis patients, and data on ex vivo IFN-γ and IL-12 production were available from 115 and 118 patients, respectively...
October 17, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27695641/cell-intrinsic-factors-modulate-the-effects-of-ifn%C3%AE-on-the-development-of-chlamydia-trachomatis
#4
Shardulendra Sherchand, Joyce A Ibana, Alison J Quayle, Ashok Aiyar
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that cannot synthesize several amino acids, including tryptophan. Rather, C. trachomatis acquires these essential metabolites from its human host cell. Chlamydial dependence on host-provided tryptophan underlies a major host defense mechanism against the bacterium; namely, the induction of the host tryptophan-catabolizing enzyme, indoleamine 2,3- dioxygenase (IDO1) by interferon gamma (IFNγ), which leads to eradication of C. trachomatis by tryptophan starvation...
August 2016: Journal of Bacteriology & Parasitology
https://www.readbyqxmd.com/read/27622767/pathway-analysis-incorporating-protein-protein-interaction-networks-identified-candidate-pathways-for-the-seven-common-diseases
#5
Peng-Lin Lin, Ya-Wen Yu, Ren-Hua Chung
Pathway analysis has become popular as a secondary analysis strategy for genome-wide association studies (GWAS). Most of the current pathway analysis methods aggregate signals from the main effects of single nucleotide polymorphisms (SNPs) in genes within a pathway without considering the effects of gene-gene interactions. However, gene-gene interactions can also have critical effects on complex diseases. Protein-protein interaction (PPI) networks have been used to define gene pairs for the gene-gene interaction tests...
2016: PloS One
https://www.readbyqxmd.com/read/27563937/ifngr2-genetic-polymorphism-associated-with-sex-specific-paranoid-schizophrenia-risk
#6
Achraf Jemli, Oumaima Inoubli, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad
BACKGROUND: Considering current scientific evidence about the significant role of chronic low grade inflammation in the physiopathology of schizophrenia, it has been hypothesized that changes in pro-inflammatory cytokines such as interferon gamma may have a significant role in the predisposition to schizophrenia. AIM: This study focuses on identifying whether the functional polymorphism of interferon gamma receptor 2 (IFNGR2) is a risk factor for the development of schizophrenia...
August 26, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27544215/association-of-genetic-polymorphisms-in-interferon-%C3%AE-interleukin-6-and-transforming-growth-factor-%C3%AE-1-gene-with-oral-lichen-planus-susceptibility
#7
Maha Ali M Al-Mohaya, Lubna Al-Otaibi, Fahad Al-Harthi, Ebtissam Al Bakr, Misbahul Arfin, Abdulrahman Al-Asmari
BACKGROUND: Oral lichen planus (OLP) is a premalignant mucocutaneous disease in which genetic factors and immune responses play a major role. Cytokines play an important role in the pathogenesis and disease progression of OLP. The aim of this study was to investigate the impact of gene polymorphisms of T helper cell subtype Th1 and Th2 cytokines, interferon-gamma (IFN-γ), interleukin-6 (IL-6) and transforming growth factor (TGF)-β1 on OLP susceptibility in a Saudi cohort. METHODS: Forty two unrelated patients with OLP and 195 healthy controls were genotyped for IFN-γ (874A/T), IL-6 (174G/C) and TGF-β1 (509C/T) polymorphisms...
2016: BMC Oral Health
https://www.readbyqxmd.com/read/27521485/high-levels-of-plasma-interferon-gamma-and-874t-a-gene-polymorphism-is-associatedwithhiv-tb-co-infection
#8
V R Gutlapalli, Aparna Sykam, Sandeep P Tenali, Sujai Suneetha, Lavanya M Suneetha
OBJECTIVE: Tuberculosis (TB) is one of the most frequent opportunistic infections in HIV patients leading to increased morbidity and death rate. This study was carried out to investigate the role of the cytokines IFN-γ and TNF-α level and their single nucleotide polymorphisms (SNPs) in HIV-TB co-infection. METHODS: 247 HIV-TB (124 HIV-pulmonary TB, 123 HIV-extra pulmonary TB), 126 HIV positive individuals without tuberculosis and 129 healthy subjects (HS) were included to measure plasma levels of IFN-γ and TNF-α by sandwich ELISA and One way ANOVA statistical analysis was carried out among the groups...
August 10, 2016: Human Immunology
https://www.readbyqxmd.com/read/27455566/-the-perspectives-of-studying-of-polymorphism-of-genes-of-gamma-interferon-under-chronic-brucellosis
#9
REVIEW
A Kh Nurpeisova, A N Kolomeietz
The brucellosis is an actual zoonotic disease in many countries, Russia included. The complexity of individual prognosis of disease and choice of tactics of maintenance of patients is explained by heterogeneity of clinical manifestations of brucellosis and different rate of progression of organs pathology. Despite of low mortality, this pathology quite often results in disability of patient. The frequent transition of acute process into chronic one (40-60%), probability of development of primary chronic brucellosis determines interest of researchers to issues of immunopathogenesis of this disease...
February 2016: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/27424131/association-of-promoter-polymorphisms-of-interleukin-10-and-interferon-gamma-genes-with-tuberculosis-in-azeri-population-of-iran
#10
Mohammad Asgharzadeh, Sajjad Ghorghanlu, Jalil Rashedi, Behroz Mahdavi Poor, Fatemeh Khaki-Khatibi, Seyyed Reza Moaddab, Hossein Samadi-Kafil, Mahya Pourostadi
Promoter polymorphism of cytokine genes may lead to inter-individual differences in cytokine levels, therefore, polymorphisms may associate with susceptibility to infectious diseases. In this study, we investigated a possible association between interleukin-10 (IL-10) -1082A⁄G (rs1800896) and interferon (IFN)-gamma +874T/A (rs2430561) promoter polymorphisms and tuberculosis (TB) in the Azeri population of Iran. IL-10 -1082G/A and IFN-gamma +874T/A single nucleotide polymorphisms (SNPs) were genotyped by amplification refractory mutation system (ARMS)-PCR in 200 healthy controls and 124 tuberculosis patients...
June 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27386381/association-of-inflammatory-gene-polymorphisms-with-mechanical-heart-valve-reoperation
#11
Kyung Eun Lee, Joo Hee Kim, Jee Eun Chung, Gwan Yung Lee, Yoon Jeong Cho, Byung Chul Chang, Hye Sun Gwak
BACKGROUND: Various complications lead to reoperation in patients who undergo prosthetic valve replacement where inflammatory process could be involved. The goals of this study were to identify risk factors that correlate with reoperation in patients with prosthetic heart valves and to investigate the relationship between reoperation and inflammatory gene polymorphisms. RESULTS: The study included 228 patients from the EwhA-Severance Treatment Group of Warfarin...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27353984/interferon-lambda-3-rs12979860-variants-and-response-to-pegylated-interferon-in-chronic-hepatitis-c-genotype-3
#12
Zaigham Abbas, Javed Yakoob, Muhammad A Umer, Ali A Azeem, Saeed S Hamid, Wasim Jafri
OBJECTIVE: To assess the role of single nucleotide polymorphisms (SNPs) near the interferon lambda-3 (IFNλ3) (formal IL-28B) gene rs12979860 in predicting sustained virologic response (SVR) in hepatitis-C virus genotype-3 (HCV-3). STUDY DESIGN: Descriptive, analytical study. PLACE AND DURATION OF STUDY: Department of Medicine, The Aga Khan University Hospital, Karachi, from July 2012 to June 2014. METHODOLOGY: Patients with HCV-3 were classified as sustained virologic response (SVR), relapsers and non-responders...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27255473/association-of-interleukin-2-and-interferon-%C3%AE-single-nucleotide-polymorphisms-with-juvenile-systemic-lupus-erythematosus
#13
S Harsini, V Ziaee, F Tahghighi, M Mahmoudi, A Rezaei, S Soltani, M Sadr, M H Moradinejad, Y Aghighi, N Rezaei
PURPOSE: Juvenile systemic lupus erythematosus (JSLE) is a severe and chronic autoimmune disease of unknown origin. Inflammatory cytokines can play a pivotal role in the pathogenesis of JSLE, while their secretion is under genetic control. The current investigation was performed to analyse the associations of particular single nucleotide polymorphisms (SNPs) of interleukin-2 (IL-2) and interferon-gamma (IFN-γ) genes in a case control study. MATERIALS AND METHODS: The allele, genotype and haplotype frequencies of the polymorphic IL-2 (G/T at -330, rs2069762, and G/T at +166, rs2069763) and IFN-γ (A/T at +874, rs2430561) genes were estimated in 59 patients with JSLE by contrast with 140 healthy controls using polymerase chain reaction with sequence-specific primers method...
September 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27125837/interferon-lambda-polymorphisms-associate-with-body-iron-indices-and-hepatic-expression-of-interferon-responsive-long-non-coding-rna-in-chronic-hepatitis-c
#14
Anna Wróblewska, Agnieszka Bernat, Anna Woziwodzka, Joanna Markiewicz, Tomasz Romanowski, Krzysztof P Bielawski, Tomasz Smiatacz, Katarzyna Sikorska
Single nucleotide polymorphisms (SNPs) within DNA region containing interferon lambda 3 (IFNL3) and IFNL4 genes are prognostic factors of treatment response in chronic hepatitis C (CHC). Iron overload, frequently diagnosed in CHC, is associated with unfavorable disease course and a risk of carcinogenesis. Its etiology and relationship with the immune response in CHC are not fully explained. Our aim was to determine whether IFNL polymorphisms in CHC patients associate with body iron indices, and whether they are linked with hepatic expression of genes involved in iron homeostasis and IFN signaling...
April 28, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27124053/interferon-gamma-genetic-polymorphism-and-expression-in-kawasaki-disease
#15
Ying-Hsien Huang, Yu-Wen Hsu, Hsing-Fang Lu, Henry Sung-Ching Wong, Hong-Ren Yu, Hsing-Chun Kuo, Fu-Chen Huang, Wei-Chiao Chang, Ho-Chang Kuo
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. IFNG gene encoding interferon (IFN)-γ, produced by natural killer cells and T cells, has been suggested to play an important role in the immunopathogenesis of Kawasaki disease. The aim of this study was to examin the correlation of gene polymorphisms of the IFNG gene and plasma levels of IFN-γ in KD patients and their outcomes.A total of 950 subjects (381 KD and 569 controls) were recruited. Three tagging single-nucleotide polymorphisms (rs2069718, rs1861493, rs2069705) were selected for TaqMan allelic discrimination assay...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27082871/monitoring-the-intracellular-tacrolimus-concentration-in-kidney-transplant-recipients-with-stable-graft-function
#16
Seung Seok Han, Seung Hee Yang, Min Chang Kim, Joo-Youn Cho, Sang-Il Min, Jung Pyo Lee, Dong Ki Kim, Jongwon Ha, Yon Su Kim
Although monitoring the intracellular concentration of immunosuppressive agents may be a promising approach to individualizing the therapy after organ transplantation, additional studies on this issue are needed prior to its clinical approval. We investigated the relationship between intracellular and whole blood concentrations of tacrolimus (IC-TAC and WB-TAC, respectively), the factors affecting this relationship, and the risk of rejection based upon IC-TAC in stable kidney recipients. Both IC-TAC and WB-TAC were measured simultaneously in 213 kidney recipients with stable graft function using LC-MS/MS...
2016: PloS One
https://www.readbyqxmd.com/read/27081842/associations-between-polymorphisms-within-interferon-gamma-and-tumor-necrosis-factor-genes-and-toxoplasma-retinochoroiditis-in-ghanaian-patients
#17
Emmanuel Kwasi Abu, Johnson N Boampong, Samuel Kyei, Richmond Afoakwah, Irene Ayi
PURPOSE: To evaluate associations between IFN-γ +874T/A and TNF-α-308G/A polymorphism with the development of Toxoplasma retinochoroiditis. METHODS: By ARMS-PCR, a cross-sectional genetic study involving 30 patients with Toxoplasma retinochoroiditis and 87 controls was carried out. RESULTS: IFN-γ +874: by comparing with the AA genotype, individuals with the TT genotype had a 3.4 odds ratio (OR); AT had a 1.6 OR; and the T allele had a higher OR (1...
April 15, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27040810/association-of-interleukin-2-but-not-interferon-gamma-single-nucleotide-polymorphisms-with-juvenile-idiopathic-arthritis
#18
M Maddah, S Harsini, A Rezaei, M Sadr, S Zoghi, M H Moradinejad, V Ziaee, N Rezaei
BACKGROUND: Cytokines, including interleukin-2 (IL-2) and interferon-gamma (IFN-γ), seem to play a role in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate the associations of IL-2 and IFN-γ single nucleotide polymorphisms (SNPs) with susceptibility to JIA in an Iranian population. METHODS: Genomic DNA of 54 Iranian patients with JIA and 139 healthy unrelated controls were typed for IL-2 (G/T at -330 and +166) as well as IFN-γ gene (A/T at +874), using polymerase chain reaction with sequence-specific primers method, and compared between patients and controls...
July 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27020872/association-of-ifn-%C3%AE-and-p2x7-receptor-gene-polymorphisms-in-susceptibility-to-tuberculosis-among-iranian-patients
#19
Mahdi Shamsi, Mohammad Reza Zolfaghari, Parissa Farnia
Interferon-gamma (IFN-γ) and P2X7 receptor are crucial for host defence against mycobacterial infections. Recent studies have indicated that IFN-γ, IFN-γ receptor 1 (IFN-γR1) andP2X7 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (TB). However, the relationship between IFN-γ and P2X7 polymorphism and TB susceptibility remains inconclusive in Iranian population. For this reason, single nucleotide polymorphisms (SNPs) in IFN-γ (G+2109A), IFN-γR1 (G-611A) and P2X7 genes (at -762, 1513 position) in patients (n = 100) were assessed using PCR-RFLP...
March 2016: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/27015189/association-of-interferon-gamma-874t-a-polymorphism-and-leukemia-risk-a-meta-analysis
#20
REVIEW
Zhitong Wu, Yifan Sun, Shengbo Zhu, Shifu Tang, Chunming Liu, Wenzhou Qin
Interferon gamma (IFN-γ) has antitumor and antiproliferative effects, and previous studies indicated IFN-γ +874T/A (rs2430561) polymorphism were related to the risk of many types of cancer. However, the association between IFN-γ +874T/A polymorphism and leukemia risk remained controversial.We performed a comprehensive meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement (PRISMA). Electronic database of Embase, Pubmed, and the Cochrane Library were searched for eligible articles published up to December 13, 2015...
March 2016: Medicine (Baltimore)
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