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Prolotherapy knee

Alketa Toska Sert, Emel Ozcan, Sina Esmaeilzadeh
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Szu-Hsuan Chen, Ta-Shen Kuan, Mu-Jung Kao, Wei-Ting Wu, Li-Wei Chou
Osteoarthritis (OA) is a degenerative disorder resulting from loss of joint cartilage and underlying bone and causes pain and loss of function. The treatment of knee OA is still a challenge because of the poor self-regeneration capacity of cartilage. The nonsurgical interventions include control of the aggravating factor (such as weight control and the use of walking aids), symptomatic treatment (such as acetaminophen or nonsteroidal anti-inflammatory drugs), prolotherapy, and viscosupplementation. However, the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) has not been widely used because of lack of clinical evidence and several limitations in patients with severe knee OA...
2016: Clinical Interventions in Aging
David Rabago, Laura van Leuven, Lane Benes, Luke Fortney, Andrew Slattengren, Jessica Grettie, Marlon Mundt
OBJECTIVE: Randomized and open-label studies assessing prolotherapy for knee osteoarthritis have found quantitative improvement on the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC) compared with baseline status and control therapies. This study assessed the qualitative response of participants receiving prolotherapy, an injection-based complementary treatment for symptomatic knee osteoarthritis (OA). DESIGN: Qualitative study using semi-structured in-depth interviews at 52 weeks after enrollment; transcribed responses were discussed by coauthors to identify themes; disagreement was resolved by consensus...
December 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ross A Hauser, Johanna B Lackner, Danielle Steilen-Matias, David K Harris
OBJECTIVE: The aim of this study was to systematically review dextrose (d-glucose) prolotherapy efficacy in the treatment of chronic musculoskeletal pain. DATA SOURCES: Electronic databases PubMed, Healthline, OmniMedicalSearch, Medscape, and EMBASE were searched from 1990 to January 2016. STUDY SELECTION: Prospectively designed studies that used dextrose as the sole active prolotherapy constituent were selected. DATA EXTRACTION: Two independent reviewers rated studies for quality of evidence using the Physiotherapy Evidence Database assessment scale for randomized controlled trials (RCTs) and the Downs and Black evaluation tool for non-RCTs, for level of evidence using a modified Sackett scale, and for clinically relevant pain score difference using minimal clinically important change criteria...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
Regina Ws Sit, Vincent Ch Chung, Kenneth D Reeves, David Rabago, Keith Kw Chan, Dicken Cc Chan, Xinyin Wu, Robin St Ho, Samuel Ys Wong
Hypertonic dextrose injections (prolotherapy) is an emerging treatment for symptomatic knee osteoarthritis (OA) but its efficacy is uncertain. We conducted a systematic review with meta-analysis to synthesize clinical evidence on the effect of prolotherapy for knee OA. Fifteen electronic databases were searched from their inception to September 2015. The primary outcome of interest was score change on the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Three randomized controlled trials (RCTs) of moderate risk of bias and one quasi-randomized trial were included, with data from a total of 258 patients...
May 5, 2016: Scientific Reports
Gastón Andrés Topol, Leandro Ariel Podesta, Kenneth Dean Reeves, Marcia Mallma Giraldo, Lanny L Johnson, Raul Grasso, Alexis Jamín, Tom Clark, David Rabago
BACKGROUND: Dextrose injection is reported to improve knee osteoarthritis (KOA)-related clinical outcomes, but its effect on articular cartilage is unknown. A chondrogenic effect of dextrose injection has been proposed. OBJECTIVE: To assess biological and clinical effects of intra-articular hypertonic dextrose injections (prolotherapy) in painful KOA. DESIGN: Case series with blinded arthroscopic evaluation before and after treatment. SETTING: Physical medicine and day surgery practice...
November 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Carlton J Covey, Marvin H Sineath, Joseph F Penta, Jeffrey C Leggit
No abstract text is available yet for this article.
December 2015: Journal of Family Practice
Masoud Hashemi, Parviz Jalili, Shirin Mennati, Alireza Koosha, Ramin Rohanifar, Firouz Madadi, Seyed Sajad Razavi, Farinaz Taheri
BACKGROUND: Knee osteoarthritis (KOA) is a common disabling disease. Limited studies have demonstrated that prolotherapy with dextrose or with prolozone can be helpful in the treatment of patients with KOA. OBJECTIVES: In the current study, we compared the results between these two treatment methods. PATIENTS AND METHODS: In the current randomized clinical trial, 80 patients with mild to moderate KOA were randomly assigned equally into two groups (ozone group and dextrose group)...
October 2015: Anesthesiology and Pain Medicine
David Rabago, Marlon Mundt, Aleksandra Zgierska, Jessica Grettie
OBJECTIVE: Knee osteoarthritis (OA) is a common, debilitating chronic disease. Prolotherapy is an injection therapy for chronic musculoskeletal pain. Recent 52-week randomized controlled and open label studies have reported improvement of knee OA-specific outcomes compared to baseline status, and blinded saline control injections and at-home exercise therapy (p<0.05). However, long term effects of prolotherapy for knee OA are unknown. We therefore assessed long-term effects of prolotherapy on knee pain, function and stiffness among adults with knee OA...
June 2015: Complementary Therapies in Medicine
Fariba Eslamian, Bahman Amouzandeh
OBJECTIVES: Prolotherapy is an injection-based complementary treatment, which has shown promising results in the treatment of different musculoskeletal disorders. The aim of this study was to determine the therapeutic efficacy of dextrose prolotherapy on pain, range of motion, and function in patients with knee osteoarthritis (OA). METHODS: In this single-arm prospective study, participants with symptomatic moderate knee osteoarthritis underwent prolotherapy with intra-articular injection of 20% dextrose water at baseline, and at 4 weeks and 8 weeks later...
April 2015: Therapeutic Advances in Musculoskeletal Disease
Poupak Rahimzadeh, Farnad Imani, Seyed Hamid Reza Faiz, Saeed Reza Entezary, Ali Akbar Nasiri, Mohsen Ziaeefard
BACKGROUND: Osteoarthritis is one of the most common diseases and the knee is the most commonly affected joint. Intra-articular prolotherapy is being utilized in acute and chronic pain management setting. This study was designed to compare the efficacy of three methods of intra-articular knee joint therapies with erythropoietin, dextrose, and pulsed radiofrequency. MATERIALS AND METHODS: After approval by the Ethics Committee and explaining the therapeutic method to volunteers, 70 patients who were suffering from primary knee osteoarthrosis went through one of the treatment methods (erythropoietin, dextrose, and pulsed radiofrequency)...
August 2014: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Andrew H Slattengren, Trent Christensen, Shailendra Prasad, Kohar Jones
No abstract text is available yet for this article.
April 2014: Journal of Family Practice
Ilker Solmaz, Suleyman Deniz, Onder Taylan Cifci
INTRODUCTION: This case report aims to discuss the clinical and radiological outcomes of prolotherapy at a patient whom to total knee prosthesis had been planned but surgery couldn't be performed due to co-morbidities. CASE PRESENTATION: A 72 year old woman presented with severe pain at her knees for over 5 years. Treatment methods include weight loss, decreasing the weight bearing on the joint, stretching exercises, nonsteroid anti-inflammatory and steroid drugs, and physiotherapy...
February 2014: Anesthesiology and Pain Medicine
David Rabago, Jeffrey J Patterson, Marlon Mundt, Aleksandra Zgierska, Luke Fortney, Jessica Grettie, Richard Kijowski
OBJECTIVES: This study determined whether injection with hypertonic dextrose and morrhuate sodium (prolotherapy) using a pragmatic, clinically determined injection schedule for knee osteoarthritis (KOA) results in improved knee pain, function, and stiffness compared to baseline status. DESIGN: This was a prospective three-arm uncontrolled study with 1-year follow-up. SETTING: The setting was outpatient. PARTICIPANTS: The participants were 38 adults who had at least 3 months of symptomatic KOA and who were in the control groups of a prior prolotherapy randomized controlled trial (RCT) (Prior-Control), were ineligible for the RCT (Prior-Ineligible), or were eligible but declined the RCT (Prior-Declined)...
May 2014: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ross A Hauser, Ingrid Schaefer Sprague
We retrospectively evaluated the effectiveness of prolotherapy in resolving pain, stiffness, and crepitus, and improving physical activity in consecutive chondromalacia patients from February 2008 to September 2009. Sixty-nine knees that received prolotherapy in 61 patients (33 female and 36 male) who were 18-82 years old (average, 47.2 years) were enrolled. Patients received 24 prolotherapy injections (15% dextrose, 0.1% procaine, and 10% sarapin) with a total of 40 cc in the anterior knee. At least 6 weeks after their last prolotherapy session, patients provided self-evaluation of knee pain upon rest, activities of daily living (ADL) and exercise, range of motion (ROM), stiffness, and crepitus...
2014: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
David Rabago, Richard Kijowski, Michael Woods, Jeffrey J Patterson, Marlon Mundt, Aleksandra Zgierska, Jessica Grettie, John Lyftogt, Luke Fortney
OBJECTIVE: To assess the relation between knee osteoarthritis (KOA)-specific quality of life (QOL) and intra-articular cartilage volume (CV) in participants treated with prolotherapy. KOA is characterized by CV loss and multifactorial pain. Prolotherapy is an injection therapy reported to improve KOA-related QOL to a greater extent than blinded saline injections and at-home exercise, but its mechanism of action is unclear. DESIGN: Two-arm (prolotherapy, control), partially blinded, controlled trial...
November 2013: Archives of Physical Medicine and Rehabilitation
David Rabago, Jeffrey J Patterson, Marlon Mundt, Richard Kijowski, Jessica Grettie, Neil A Segal, Aleksandra Zgierska
PURPOSE: Knee osteoarthritis is a common, debilitating chronic disease. Prolotherapy is an injection therapy for chronic musculoskeletal pain. We conducted a 3-arm, blinded (injector, assessor, injection group participants), randomized controlled trial to assess the efficacy of prolotherapy for knee osteoarthritis. METHODS: Ninety adults with at least 3 months of painful knee osteoarthritis were randomized to blinded injection (dextrose prolotherapy or saline) or at-home exercise...
May 2013: Annals of Family Medicine
Yong-Geun Park, Seung Beom Han, Sang Jun Song, Tae Jin Kim, Chul-Won Ha
Platelet-rich plasma (PRP) is a concentrate extract of platelets from autologous blood, and represents a possible treatment option for the stimulation and acceleration of soft-tissue healing and regeneration in orthopedics. Currently, the availability of devices for outpatient preparation and delivery contributes to the increase in the clinical use of PRP therapy in practical setting of orthopedic fields. However, there is still paucity of scientific evidence in the literature to prove efficacy of PRP therapy for the treatment of ligament or tendon problems around the knee joint...
June 2012: Knee Surgery & related Research
David Rabago, Aleksandra Zgierska, Luke Fortney, Richard Kijowski, Marlon Mundt, Michael Ryan, Jessica Grettie, Jeffrey J Patterson
OBJECTIVE: The objective of this study was to determine whether prolotherapy, an injection-based complementary treatment for chronic musculoskeletal conditions, improves pain, stiffness, and function in adults with symptomatic knee osteoarthritis (KOA) compared to baseline status. DESIGN: This was a prospective, uncontrolled study with 1-year follow-up. SETTING: The study was conducted in an outpatient setting. PARTICIPANTS: Adults with at least 3 months of symptomatic KOA, recruited from clinical and community settings, participated in the study...
April 2012: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Walter Grote, Rosa Delucia, Robert Waxman, Aleksandra Zgierska, John Wilson, David Rabago
OBJECTIVE AND IMPORTANCE: Surgical reconstruction is considered definitive treatment for anterior cruciate ligament (ACL) tears but precise surgical indications are debated. Some patients are reluctant or inappropriate surgical candidates. Prolotherapy is a non-surgical injection therapy for chronic musculoskeletal pain and instability. This case report documents the non-surgical repair of a torn ACL using prolotherapy and at-home exercise. CLINICAL PRESENTATION AND INTERVENTION: The 18 year old female patient sustained a right knee injury during a downhill skiing accident...
December 1, 2009: International Musculoskeletal Medicine
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