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Gluten-related disorder

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https://www.readbyqxmd.com/read/27887897/nomenclature-and-diagnosis-of-gluten-related-disorders-a-position-statement-by-the-italian-association-of-hospital-gastroenterologists-and-endoscopists-aigo
#1
REVIEW
Luca Elli, Danilo Villalta, Leda Roncoroni, Donatella Barisani, Stefano Ferrero, Nicoletta Pellegrini, Maria Teresa Bardella, Flavio Valiante, Carolina Tomba, Antonio Carroccio, Massimo Bellini, Marco Soncini, Renato Cannizzaro, Gioacchino Leandro
BACKGROUND: "Gluten-related disorders" is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them. AIM: To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood. METHODS: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest...
November 4, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27825568/osteoarticular-manifestations-of-celiac-disease-and-non-celiac-gluten-hypersensitivity
#2
Stéphanie Dos Santos, Frédéric Lioté
Celiac disease is a chronic inflammatory autoimmune enteropathy based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The global prevalence of 1% to 2% represents only the tip of the iceberg. The diagnosis is confirmed by positive specific antibody, anti-transglutaminase or anti-endomysium, specific lesions of the small intestine and a response to strict gluten-free diet. The diagnosis is difficult and often delayed because the clinical variability is very large, ranging from digestive clinical presentation "classic" to "atypical" symptoms, often extra-intestinal, that are sometimes attributed to a concomitant disease or a complication...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27808487/pathophysiology-of-non-celiac-gluten-sensitivity-where-are-we-now-in-2016
#3
Giacomo Caio, Gabriele Riegler, Marta Patturelli, Angela Facchiano, Laura DE Magistris, Anna Sapone
Non-celiac gluten sensitivity (NCGS) is the term used to describe individuals complaining of intestinal and extra-intestinal symptoms related to gluten ingestion and rapidly improving after its withdrawal, and in which both celiac disease (CD) and wheat allergy (WA) were properly ruled out. The prevalence of this condition remains unknown and a lot of questions about the possible pathogenetic mechanisms are still unclarified. It is believed that NCGS represents a heterogeneous condition with different subgroups potentially characterized by different pathogenesis, clinical history, and clinical course...
November 3, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27792210/animal-models-to-study-non-celiac-gluten-sensitivity
#4
Plaimein Amnuaycheewa, Joseph A Murray, Eric V Marietta
Non-celiac gluten sensitivity (NCGS), sometimes known as non-celiac wheat sensitivity (NCWS), has recently received much attention, both scientific as well as from the alternative medical community. Over the past 5 years, there are over 200 publications on NCGS indexed on PubMed database, the gluten-free market has been growing bigger, and it is clear that the number of consumers who are on a gluten-free diet (GFD) possibly because of a suspicion for NCGS appears to grow even faster. Nevertheless, despite these three rising events, many questions about NCGS remain unresolved...
October 28, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27765080/survey-of-thai-commercial-food-products-that-have-been-reported-to-contain-no-wheat-rye-barley-or-gluten-according-to-their-labels
#5
Sirinrat Srikulnath, Vipa Surojanametakul, Pailin Chamnansin, Hirotoshi Tamura, Masahiro Shoji
Celiac disease (CD) and gluten-related disorders are significant health and social issues in Western countries, and CD individuals need to exclude gluten from their diets. The adverse health impacts of CD have extended to Asian countries in which CD was not a problem previously. Thai commercial food products that do not contain wheat, rye, barley, or gluten on their labels were surveyed as to whether they were suitable for CD individuals by examining the absence of gluten or the presence of gluten <20 ppm...
October 19, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27763541/properties-of-gluten-intolerance-gluten-structure-evolution-pathogenicity-and-detoxification-capabilities
#6
Anastasia V Balakireva, Andrey A Zamyatnin
Theterm gluten intolerance may refer to three types of human disorders: autoimmune celiac disease (CD), allergy to wheat and non-celiac gluten sensitivity (NCGS). Gluten is a mixture of prolamin proteins present mostly in wheat, but also in barley, rye and oat. Gluten can be subdivided into three major groups: S-rich, S-poor and high molecular weight proteins. Prolamins within the groups possess similar structures and properties. All gluten proteins are evolutionarily connected and share the same ancestral origin...
October 18, 2016: Nutrients
https://www.readbyqxmd.com/read/27747460/non-celiac-gluten-sensitivity
#7
Maria Teresa Bardella, Luca Elli, Francesca Ferretti
PURPOSE OF REVIEW: A new syndrome responding to gluten-free diet and defined non-celiac gluten sensitivity entered the spectrum of gluten-related disorders, together with celiac disease and wheat allergy. However, its definition, prevalence, diagnosis, pathogenesis, treatment, and follow up are still controversial. The purpose of the review is to summarize the evidence and problems emerging from the current literature. RECENT FINDINGS: Direct implication of gluten in the onset of symptoms is often unproved as a low fermentable oligo-, di- and mono-saccharides and polyols diet or other components of cereals as wheat amylase trypsin inhibitor could be similarly involved...
December 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27731558/non-celiac-gluten-sensitivity-ncgs
#8
Pravin M Rathi, Vinay G Zanwar
There has been increasing interest in the entity "Non-celiac gluten sensitivity" in recent years which was first of its in 1980s. This "re-discovered" disorder is characterized by intestinal and extra-intestinal symptoms which occur after ingestion of gluten containing food. The number of such patients who neither have celiac disease nor wheat allergy, but appear to benefit from gluten withdrawal is increasing substantially. However it still remains a controversial and its pathogenesis is not well understood...
March 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27729985/alcohol-related-cerebellar-degeneration-not-all-down-to-toxicity
#9
Priya D Shanmugarajah, Nigel Hoggard, Stuart Currie, Daniel P Aeschlimann, Pascale C Aeschlimann, Dermot C Gleeson, Mohammed Karajeh, Nicola Woodroofe, Richard A Grünewald, Marios Hadjivassiliou
BACKGROUND: Alcohol-related cerebellar degeneration is one of the commonest acquired forms of cerebellar ataxia. The exact pathogenic mechanisms by which alcohol leads to cerebellar damage remain unknown. Possible autoreactive immune mediated mechanisms have not been explored previously. In this study, we aim to investigate the potential role of alcohol-induced immune mediated cerebellar degeneration. METHODS: Patients with ataxia and a history of alcohol misuse were recruited from the Ataxia and Hepatology tertiary clinics at Sheffield Teaching Hospitals NHS Trust...
2016: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/27701694/-celiac-disease
#10
Michael Schumann, Lydia Lebenheim
Celiac disease occurs as a result of a T-cell-dependent immune reaction on gluten peptides. It is a complex genetic disorder that is mediated by an unknown number of genes, of which more than 50 have been identified in whole genome association studies. The genetic component helps identify oligosymptomatic or even subclinical celiacs by screening first-degree relatives and patients suffering from other autoimmune diseases. To offer sensitive as well as specific diagnostics for celiac disease (serology and small intestinal histology) some general rules should be followed including performing diagnostics only when patients are on a gluten-containing diet or after an appropriate re-exposition...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27672296/may-the-assessment-of-baseline-mucosal-molecular-pattern-predict-the-development-of-gluten-related-disorders-among-microscopic-enteritis
#11
Giuseppe Losurdo, Floriana Giorgio, Domenico Piscitelli, Lucia Montenegro, Claudia Covelli, Maria Grazia Fiore, Antonio Giangaspero, Andrea Iannone, Mariabeatrice Principi, Annacinzia Amoruso, Michele Barone, Alfredo Di Leo, Enzo Ierardi
AIM: To evaluate mucosal baseline mRNA expression of tissue transglutaminase 2 (tTG2), interferon gamma (IFNγ), toll-like receptor 2 (TLR2) and Myeloid Differentiation factor 88 (MyD88) in patients with microscopic enteritis (ME). METHODS: We retrospectively enrolled 89 patients with ME of different etiology, which was defined within a 2-year mean period of follow-up. Baseline histological examination was performed on Hematoxylin-Eosin stained sections and CD3 lymphocyte immunohistochemistry was used for intraepithelial lymphocyte count (IELs)...
September 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27659035/coeliac-disease-immunogenicity-studies-of-barley-hordein-and-rye-secalin-derived-peptides
#12
Widya A Wahab, Tanja Šuligoj, Julia Ellis, Beatriz Côrtez-Real, Paul J Ciclitira
Coeliac disease (CD) is an inflammatory disorder of the small intestine. It includes aberrant adaptive immunity with presentation of CD toxic gluten peptides by HLA-DQ2 or DQ8 molecules to gluten-sensitive T cells. A ω-gliadin/C-hordein peptide (QPFPQPEQPFPW) and a rye-derived secalin peptide (QPFPQPQQPIPQ) were proposed to be toxic in CD, as they yielded positive responses when assessed with peripheral blood T-cell clones derived from individuals with CD. We sought to assess the immunogenicity of the candidate peptides using gluten-sensitive T-cell lines obtained from CD small intestinal biopsies...
August 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27648068/self-reported-prevalence-of-gluten-related-disorders-and-adherence-to-gluten-free-diet-in-colombian-adult-population
#13
Francisco Cabrera-Chávez, Diana María Granda-Restrepo, Jesús Gilberto Arámburo-Gálvez, Alejandro Franco-Aguilar, Dalia Magaña-Ordorica, Marcela de Jesús Vergara-Jiménez, Noé Ontiveros
Background. Celiac disease seems to be rare in Colombians, but there are currently no data about the prevalence rates of symptomatic adverse reactions to gluten or adherence to gluten-free diet (GFD) in this population. Aim. to evaluate the self-reported prevalence rates of adverse reactions to gluten, adherence to GFD, and gluten-related disorders at population level in Colombia. Methods. A self-administered questionnaire-based cross-sectional study was conducted in a population from Northwest Colombia. Results...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27647538/mood-disorders-and-non-celiac-gluten-sensitivity
#14
Giovanni Casella, Roberta Pozzi, Marta Cicognetti, Francesco Bachetti, Gabriele Torti, Moris Cadei, Vincenzo Villanacci, Vittorio Baldini, Gabrio Bassotti
The association between gluten related disorders and psychiatric diseases has been firmly demonstrated. Non celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients responsive to gluten free diet after ruling out celiac disease and wheat allergy. The pathogenesis of neuro-psychiatric disorders in NCGS is unclear. An association between gluten and schizophrenia was described for the first time in 1950 by Bender et al. In the 50', Dicke noted that gluten free diet improved mood in celiac patients...
September 20, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27606948/is-there-a-relationship-between-gluten-sensitivity-and-postural-tachycardia-syndrome
#15
Hugo A Penny, Imran Aziz, Melloney Ferrar, Jayne Atkinson, Nigel Hoggard, Marios Hadjivassiliou, John N West, David S Sanders
BACKGROUND: We have noticed that patients with postural tachycardia syndrome (PoTS) were placing themselves on a gluten-free diet without medical consultation. Therefore, we aimed to evaluate the prevalence of coeliac disease and self-reported gluten sensitivity in a cohort of patients with PoTS and compare this with local population data. METHODS: A total of 100 patients with PoTS were recruited to complete a questionnaire that screened for gluten sensitivity, related symptoms and dietary habits...
September 7, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27605538/the-clinical-and-phenotypical-assessment-of-seronegative-villous-atrophy-a-prospective-uk-centre-experience-evaluating-200-adult-cases-over-a-15-year-period-2000-2015
#16
Imran Aziz, Mohammad F Peerally, Jodie-Hannah Barnes, Vigneswaran Kandasamy, Jack C Whiteley, David Partridge, Patricia Vergani, Simon S Cross, Peter H Green, David S Sanders
BACKGROUND: Seronegative villous atrophy (SNVA) is commonly attributed to coeliac disease (CD). However, there are other causes of SNVA. More recently angiotensin-2-receptor-blockers (A2RBs) have been reported as an association but data on SNVA have been limited to centres evaluating complex case referrals and not SNVA in general. OBJECTIVES: To provide clinical outcomes and associations in a large prospective study overseeing all newcomers with SNVA. DESIGN: Over a 15-year period (2000-2015) we evaluated 200 adult patients with SNVA at a UK centre...
September 7, 2016: Gut
https://www.readbyqxmd.com/read/27556094/endoscopic-evaluation-of-celiac-disease-severity-and-its-correlation-with-histopathological-aspects-of-the-duodenal-mucosa
#17
Mauro W Bonatto, Luiz Kotze, Marcia Orlandoski, Ricardo Tsuchyia, Carlos A de Carvalho, Doryane Lima, Gustavo Kurachi, Ivan R B Orso, Lorete Kotze
BACKGROUND AND STUDY AIMS: Celiac disease (CD) is a chronic systemic autoimmune disorder affecting genetically predisposed individuals, triggered and maintained by the ingestion of gluten. Triggered and maintained by the ingestion of gluten, celiac disease is a chronic systemic autoimmune disorder affecting genetically predisposed individuals. Persistent related inflammation of the duodenal mucosa causes atrophy architecture detectable on esophagogastroduodenoscopy (EGD) and histopathology...
July 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27552857/alterations-in-diets-of-patients-with-nonceliac-gluten-sensitivity-compared-with-healthy-individuals
#18
Fabiana Zingone, Chiara Bartalini, Monica Siniscalchi, Monica Ruotolo, Cristina Bucci, Ivonne Morra, Paola Iovino, Carolina Ciacci
BACKGROUND & AIMS: There is evidence that food components beyond gluten cause symptoms in patients with gluten sensitivity without celiac disease (nonceliac gluten sensitivity [NCGS]). We investigated the diets and nutritional characteristics of patients with NCGS. METHODS: We performed a prospective observational study of 29 patients with NCGS seen at the outpatient clinic for celiac disease and other food intolerances of the University of Salerno in Italy from September 2015 through April 2016...
August 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27548732/the-effects-of-a-gluten-free-diet-versus-a-hypocaloric-diet-among-patients-with-fibromyalgia-experiencing-gluten-sensitivity-like-symptoms-a-pilot-open-label-randomized-clinical-trial
#19
Mahmoud Slim, Elena P Calandre, Juan M Garcia-Leiva, Fernando Rico-Villademoros, Rocio Molina-Barea, Carmen M Rodriguez-Lopez, Piedad Morillas-Arques
BACKGROUND AND AIMS: Patients with fibromyalgia frequently present with symptoms similar to those experienced by patients with gluten-related disorders, raising the possibility that a subgroup of these patients could be experiencing underlying gluten sensitivity. This study aimed to evaluate the effects of a gluten-free diet (GFD) compared with a hypocaloric diet (HCD) among patients with fibromyalgia. METHODS: Adult patients diagnosed with fibromyalgia were randomly allocated to receive a GFD or a HCD over a 24-week period...
August 19, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27545437/anti-gm1-ganglioside-antibodies-neuron-specific-enolase-and-interleukin-10-concentrations-as-potential-markers-of-autonomic-nervous-system-impairment-in-celiac-disease-preliminary-findings
#20
Magdalena Przybylska-Feluś, Małgorzata Zwolińska-Wcisło, Agnieszka Piątek-Guziewicz, Agata Furgała, Kinga Sałapa, Tomasz Mach
INTRODUCTION    Celiac disease (CD) is an immune-mediated enteropathy related to permanent gluten intolerance with numerous clinical manifestations such as typical gastrointestinal symptoms as well as atypical and asymptomatic forms including neurological symptoms. Presence of neuron-specific enolase (NSE), interleukin 10 (IL-10) and anti-ganglioside antibodies have been demonstrated for several neurological conditions as well as immunological disorders with neurological manifestations.  OBJECTIVES    The aim of the study was to determine IL-10, NSE and anti-GM1 antibodies concentrations in the course of celiac disease and their correlation with changes in electrogastrography (EGG) and heart rate variability (HRV) recordings...
August 22, 2016: Polskie Archiwum Medycyny Wewnętrznej
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