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Antisocial personality disorder medications

Susan Young, Rafael A González, Kim Wolff, Kiriakos Xenitidis, Laura Mutch, Isabella Malet-Lambert, Gisli H Gudjonsson
OBJECTIVE: The objective of the study is to quantify the extent of specific polysubstance use, drug transitions to current substances, and describe the association with alcohol use disorders among inmates with ADHD. We also examined health risk behaviors and patterns of offending in relation with ADHD. METHOD: A total of 387 male British prison inmates were screened and interviewed via the Diagnostic Interview for ADHD in Adults 2.0 (DIVA-2). RESULTS: Male prisoners with ADHD endorse more methadone and amphetamine use...
January 1, 2017: Journal of Attention Disorders
John Kasinathan, Gillian Sharp, Anthony Barker
OBJECTIVES: Olanzapine is a well established treatment for schizophrenia. The olanzapine pamoate depot (long-acting injectable) formulation improves compliance and clinical trials have shown it to be effective. However, there are no previously published reports evaluating olanzapine depot in violent patients with schizophrenia in the community. We evaluated the clinical efficacy of olanzapine depot, its effect on violence, hospitalization and incarceration in community patients with schizophrenia and prior history of serious violence...
October 2016: Therapeutic Advances in Psychopharmacology
Sheilagh Hodgins, Sanja Klein
OBJECTIVE: To review findings with clinical relevance that add to knowledge about antisocial and aggressive behaviour among persons with schizophrenia. METHOD: Nonsystematic literature review. RESULTS: Recent evidence shows that individuals who develop schizophrenia present cognitive deficits, psychotic-like experiences, and internalizing and externalizing problems from childhood onwards. Many of their relatives present not only schizophrenia-related disorders but also antisocial behaviour...
February 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
R Karrouri
INTRODUCTION: Self-mutilating behaviour is expanding, especially among adolescents and patients with a psychiatric disorder. CLINICAL MATERIAL: We have tried to describe the self-mutilating behaviour in Moroccan inpatients of the psychiatric department of Mohammed V Military Hospital of Rabat, through a prospective and descriptive longitudinal study over a period of four months, based on a questionnaire prepared according to the literature data to allow discussing its results...
June 24, 2016: L'Encéphale
S Bonnet, M Lacambre, A Schandrin, D Capdevielle, P Courtet
INTRODUCTION: Violence committed by individuals with severe mental illness has become an increasing focus of concern among clinicians, policy makers, and the general public, often as the result of tragic events. Research has shown in the past two decades an increased risk of violence among patients with mental disorder. Nevertheless, of those suffering from mental illness, perpetrators of other directed violence form a minority subgroup. The means by which there is this association between mental illness and violence has remained controversial...
April 2017: L'Encéphale
Royce Lee, Konstantinos Arfanakis, Arnold M Evia, Jennifer Fanning, Sarah Keedy, Emil F Coccaro
Intermittent explosive disorder (IED), as described in DSM-5, is the categorical expression of pathological impulsive aggression. Previous work has identified neurobiological correlates of the disorder in patterns of frontal-limbic brain activity and dysregulation of serotonergic neurotransmission. Given the importance of short- and-long range white matter connections of the brain in social and emotional behavior, studies of white matter connectivity in impulsive aggression are warranted. Diffusion tensor imaging (DTI) studies in the related conditions of antisocial and borderline personality disorder have produced preliminary evidence of disturbed white matter connectivity in these disorders, but to date there have been no DTI studies in IED...
October 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
A El-Gilany, M Khater, Z Gomaa, E Hussein, I Hamdy
OBJECTIVES: To estimate the overall prevalence of psychiatric disorders among prisoners and its associated factors, and to estimate the prevalence of different mental and personality disorders. METHODS: This was a cross-sectional descriptive study carried out in 16 randomly selected prisons in Egypt. A stratified proportional random sample of 1350 adult prisoners was included in the study. Data were collected by a psychiatrist by direct interview with prisoners...
March 2016: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
Carol Chu, Jennifer M Buchman-Schmitt, Thomas E Joiner, M David Rudd
This study characterizes the personality disorder (PD) symptoms of patients who endorse a perplexing combination of low desire and high plans for suicide. Five PD (antisocial, narcissistic, borderline, dependent, avoidant) symptoms were examined at the junction of two suicide risk factors: (a) suicidal desire/ideation and (b) resolved plans/preparations. Participants (N = 250) were recruited from U.S. Army Medical Center affiliated sites, including two outpatient clinics, an inpatient facility, and an emergency room...
April 2017: Journal of Personality Disorders
Eila Repo-Tiihonen, Tero Hallikainen
Antisocial personality disorder (ASP), especially psychopathy as its extreme form, has provoked fear and excitement over thousands of years. Ruthless violence involved in the disorder has inspired scientists, too.The abundance of research results concerning epidemiology, physiology, neuroanatomy, heritability, and treatment interventions has made ASP one of the best documented disorders in psychiatry. Numerous interventions have been tested, but there is no current treatment algorithm. Biological and sociological parameters indicate the importance of early targeted interventions among the high risk children...
2016: Duodecim; Lääketieteellinen Aikakauskirja
Kelly E Dunn, Van L King, Robert K Brooner
BACKGROUND: Adherence with psychiatric medication is a critical issue that has serious individual and public health implications. This is a secondary analysis of a large-scale clinical treatment trial of co-occurring substance use and psychiatric disorder. METHOD: Participants (n=153) who received a clinically-indicated psychiatric medication ≥30 days during the 12-month study and provided corresponding data from Medication Event Monitoring System (MEMS) and Morisky Medication Taking Adherence Scale (MMAS) self-report adherence ratings were included in the analyses...
March 1, 2016: Drug and Alcohol Dependence
Sarah Ritter, Lois M Platt
Psychiatric unit inpatients often have serious mental illnesses with comorbid personality disorders. Mental illnesses usually respond favorably to medication and psychotherapy, but personality disorders do not. Two personality disorders are commonly seen on inpatient units: borderline and antisocial. These personality disorders may destabilize the milieu with disruptive behaviors and present a challenge to nurses. Difficult patient behaviors and therapeutic responses by nurses are examined. Dialectical behavior therapy techniques and good communication skills may be used by nurses to (a) interact therapeutically with patients with personality disorders and (b) protect other patients and the milieu...
January 2016: Journal of Psychosocial Nursing and Mental Health Services
Joni Teoh Bing Fei, Anne Yee, Mohamad Hussain Bin Habil
BACKGROUND AND OBJECTIVES: Co-occurring psychiatric disorders are among the difficulties faced by patients with opioid dependence on methadone maintenance therapy (MMT). This study aims to assess the prevalence of psychiatric comorbidity among patients on MMT, the factors predicting psychiatric comorbidity and to examine the association between psychiatric comorbidity and quality of life. METHODS: A total of 225 male patients on MMT in a tertiary hospital in Malaysia were assessed for psychiatric comorbidity and substance use disorders using the Mini-International Neuropsychiatric Interview (MINI) and Opiate Treatment Index (OTI)...
January 2016: American Journal on Addictions
Tomer Levy, Yuval Bloch, Meytal Bar-Maisels, Galia Gat-Yablonski, Amir Djalovski, Katy Borodkin, Alan Apter
Callous-unemotional (CU) traits correlate with the severity and prognosis of conduct disorder in youth. The neuropeptide oxytocin (OT) has been linked to prosocial behaviors, including empathy and collaboration with others. This study discusses a possible role for OT in the biology of delinquent behavior. We hypothesized that in delinquent youth OT secretion will correlate with the severity of conduct problems and specifically with the level of CU traits. The study group included 67 male adolescents (mean age 16...
December 2015: European Child & Adolescent Psychiatry
Simasadat Noorbakhsh, Zahra Zeinodini, Zeynab Khanjani, Hamid Poorsharifi, Sepideh Rajezi Esfahani
BACKGROUND: Individuals with certain personality disorders, especially the antisocial and borderline personality disorders, are more prone to substance use disorders. OBJECTIVES: Regarding the importance of substance use disorders, this study aimed to explore the association between personality disorders and types of used drugs (narcotics and stimulants) in Iranian male substance users. PATIENTS AND METHODS: The current study was a correlation study...
June 2015: Iranian Red Crescent Medical Journal
Donald W Black
Antisocial personality disorder (ASPD) is characterized by a pattern of socially irresponsible, exploitative, and guiltless behaviour. ASPD is associated with co-occurring mental health and addictive disorders and medical comorbidity. Rates of natural and unnatural death (suicide, homicide, and accidents) are excessive. ASPD is a predictor of poor treatment response. ASPD begins early in life, usually by age 8 years. Diagnosed as conduct disorder in childhood, the diagnosis converts to ASPD at age 18 if antisocial behaviours have persisted...
July 2015: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Lindsey Colman McKernan, Michael R Nash, William H Gottdiener, Scott E Anderson, Warren E Lambert, Erika R Carr
According to Khantzian's (2003) self-medication hypothesis (SMH), substance dependence is a compensatory means to modulate affects and self-soothe in response to distressing psychological states. Khantzian asserts: (1) Drugs become addicting because they have the power to alleviate, remove, or change human psychological suffering, and (2) There is a considerable degree of specificity in a person's choice of drugs because of unique psychological and physiological effects. The SMH has received criticism for its variable empirical support, particularly in terms of the drug-specificity aspect of Khantzian's hypothesis...
June 2015: Psychodynamic Psychiatry
J Guivarch, M-D Piercecchi-Marti, D Glezer, J-M Chabannes
INTRODUCTION: Forensic psychiatric assessment regarding liability ensures a balance between justice and psychiatry. In France, criminal assessment is not contradictory. The psychiatric expert is commissioned by judges to determine whether or not the accused has a mental disorder and specify whether it affects discernment and control of actions at the time of offense. Its mission focuses on the mental element required to constitute an offense, and is structured around Article 122-1 of the Criminal Code...
June 2015: L'Encéphale
Päivi Viitanen, Heikki Vartiainen, Jorma Aarnio, Virpi von Gruenewaldt, Tomi Lintonen, Aino K Mattila, Terhi Wuolijoki, Matti Joukamaa
PURPOSE: In a health survey of Finnish prisoners in 2006, the authors aimed to study frequency and gender differences in childhood physical and sexual abuse, and the connections of maltreatment in childhood to substance abuse and mental health among female and male prisoners. DESIGN/METHODOLOGY/APPROACH: The sample consisted of 101 female prisoners, with 309 male prisoners for comparison. The subjects participated in a comprehensive field study consisting of several questionnaires, interviews, the Structured Clinical Interview for DSM-IV Axis I and II Disorders (SCID I, II) and a clinical medical examination including ICD-10 diagnoses...
2011: International Journal of Prisoner Health
Matt Bruce, Dionne Laporte
BACKGROUND: Prevalence of childhood trauma is elevated among individuals with severe mental illness (SMI) compared to the general population and associated with poor prognosis, substance misuse, lower treatment compliance and violence. Antisocial personality disorder (ASPD) typologies (childhood vs adult onset) also represent possible mediating mechanisms to explain risk of violence among men with SMI. The current study aimed to explore an explanatory pathway linking childhood traumatic exposure, antisocial personality typologies and risk of violent behaviour among adult male inpatients with SMI...
March 2015: Schizophrenia Research
Angelica Clément, Katherine Raymond, Svetlana Puzhko, Julie Bruneau, Didier Jutras-Aswad
Background Cluster-B personality disorders (DSM-V), particularly borderline and antisocial personality disorders, are associated with high rates of substance use disorder. However, the mechanisms underlying this relationship have yet to be fully understood. Craving has recently been identified as an important component of substance use disorder. The purpose of this article is therefore to review the current literature and explore whether craving could be implicated as an underlying mechanism of comorbid substance use disorder in antisocial and borderline personality disorders...
2014: Santé Mentale Au Québec
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