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Drug delivery devices

A Rodríguez, M Cabrera, L F Reyes, M Bodí, S Trefler, L Canadell, D Barahona, S Ehrmann, I Martin-Loeches, M I Restrepo, L Vecellio
BACKGROUND: The delivery profile of Aztreonam lysine (AZLI) during mechanical ventilation (MV) is unknown. We evaluated the amount of AZLI drug delivered using an in vitro model of adult MV. METHODS: An adult lung model designed to mimic current clinical practice was used. Both nebulizers were placed before a Y-piece and 4 settings were tested: A) Aeroneb solo® [AS] with a t-piece; B) AS with the spacer; C) M-Neb® [MN] with a t-piece and D) MN with the spacer...
October 18, 2017: Expert Opinion on Drug Delivery
G Ij Salentijn, R D Oleschuk, E Verpoorte
In this work we present the application of 3D-printing for the miniaturization and functionalization of an ion source for (portable) mass spectrometry (MS). Two versions of a 3D-printed cartridge for paper spray ionization (PSI) are demonstrated, assessed, and compared. We first focus on the use of 3D-printing to enable the integration of an embedded electrostatic lens and a manifold for internal sheath gas distribution and delivery. Cartridges with and without a sheath gas manifold and an electrostatic lens are compared with respect to analytical performance and operational flexibility...
October 17, 2017: Analytical Chemistry
JiYong Lee, Dae Hyun Kim, Kang Ju Lee, Il Ho Seo, Seung Hyun Park, Eui Hwa Jang, Youngjoo Park, Young-Nam Youn, WonHyoung Ryu
After surgical procedures such as coronary/peripheral bypass grafting or endarterectomy for the treatment of organ ischemia derived from atherosclerosis, intimal hyperplasia (IH) which leads to restenosis or occlusion at the site of graft anastomosis frequently occurs. In order to inhibit IH caused by abnormal growth of smooth muscle cells (SMCs) in tunica media, various perivascular drug delivery devices are reported for delivery of anti-proliferation drugs into vascular tissue. However, there still remain conflicting requirements such as local and unidirectional delivery vs device porosity, and conformal tight device installation vs pulsatile expansion and constriction of blood vessels...
October 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
A Maroni, A Melocchi, F Parietti, A Foppoli, L Zema, A Gazzaniga
In the drug delivery area, versatile therapeutic systems intended to yield customized combinations of drugs, drug doses and release kinetics have drawn increasing attention, especially because of the advantages that personalized pharmaceutical treatments would offer. In this respect, a previously proposed capsular device able to control the release performance based on its design and composition, which could extemporaneously be filled, was improved to include multiple separate compartments so that differing active ingredients or formulations may be conveyed...
October 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Doo Sun Sim, Myung Ho Jeong
Delayed arterial healing at culprit sites after drug-eluting stent (DES) placement for acute myocardial infarction (AMI) is associated with increased risk of late stent thrombosis. The Korea Acute Myocardial Infarction Registry was established in commemoration of the 50(th) anniversary of Korea Circulation Society. Between November 2005 and December 2016, more than 62,000 patients were registered from 50 primary percutaneous coronary intervention (PCI) centers in Korea. DES in AMI may be safe and effective, however, there is concern about increased stent thrombosis after DES implantation in AMI patients, requiring longer-term dual anti-platelet therapy to reduce the risk of late stent thrombosis...
September 2017: Chonnam Medical Journal
Baocheng Tian, Qi Yan, Juan Wang, Chen Ding, Sixiang Sai
Candida commonly adheres to implanted medical devices and forms biofilms. Due to the minimal activity of current antifungals against biofilms, new drugs or drug-delivery systems to treat these persistent infections are urgently needed. In the present investigation, voriconazole-loaded nanostructured lipid carriers (Vrc-NLCs) were formulated for enhanced drug-delivery efficiency to C. albicans to increase the antifungal activity of Vrc and to improve the treatment of infectious Candida diseases. Vrc-NLCs were prepared by a hot-melt, high-pressure homogenization method, and size distribution, ζ-potential, morphology, drug-encapsulation efficiency, drug loading, and physical stability were characterized...
2017: International Journal of Nanomedicine
M S Blundell, P I Dargan, D M Wood
Background: There is limited published scientific data on vaping recreational drugs other than cannabis. A recent review suggested that 15% of people vaping cannabis have also vaped a synthetic cannabinoid receptor agonist (SCRA) and identified over 300 Internet reports of e-liquid manufacture of recreational drugs and/or new psychoactive substances (NPS). Aim: To determine the prevalence of use of electronic vaping devices for recreational drug and NPS delivery in the UK...
September 14, 2017: QJM: Monthly Journal of the Association of Physicians
Lari K Dkhar, Jim Bartley, David White, Ali Seyfoddin
This review article highlights the importance and advantages of the drug delivery systems applied via the nasal route after endoscopic sinus surgery (ESS) for patients suffering from chronic rhinosinusitis. After ESS, patients often require ongoing topical and systemic medication. To reduce the incidence of immediate and delayed post-surgical complications, a variety of temporary postoperative nasal interventions are currently used. However, newly developed intranasal drug delivery devices can enhance tissue recovery after endoscopic sinus surgery by releasing therapeutic drugs locally, while providing structural support to reduce tissue adhesion and scaring...
October 10, 2017: Pharmaceutical Development and Technology
Ali Q Alorabi, Mark D Tarn, Jenifer Gómez-Pastora, Eugenio Bringas, Inmaculada Ortiz, Vesselin N Paunov, Nicole Pamme
Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing steps that render the process repetitive and time-consuming. Here, ferrofluid droplets were explored for this purpose as an elegant alternative of templates that can be easily manipulated via an external magnetic field, and require only a simple microfluidic chip design and setup...
October 9, 2017: Lab on a Chip
Yang Zhang, Peng Yang, Madathumpady Abubaker Habeeb Muhammed, Shahad K Alsaiari, Basem Moosa, Abdulaziz Almalik, Anjli Kumar, Emilie Ringe, Niveen M Khashab
Controlling the size, number, and shape of nanogaps in plasmonic nanostructures is of significant importance for the development of novel quantum plasmonic devices and quantitative sensing techniques such as surface-enhanced Raman scattering (SERS). Here, we introduce a new synthetic method based on coordination interactions and galvanic replacement to prepare core-shell plasmonic nanorods with tunable enclosed nanogaps. Decorating Au nanorods with Raman reporters that strongly coordinate Ag(+) ions (e.g., 4-mercaptopyridine) afforded uniform nucleation sites to form a sacrificial Ag shell...
October 18, 2017: ACS Applied Materials & Interfaces
Farhan Ahmad
Silver nanoparticles (AgNPs), are amongst the utmost striking nanosized materials that are extensively applied in a variety of biomedical applications which includes diagnostic use, disease management, medical device coating, drug delivery and for personal health care. With the growing interest and the use of AgNPs in the health care sector, it is becoming essential for a better understanding of AgNPs mechanism of action like biological interaction, their possible toxicity, and safety concern to human exposure...
October 6, 2017: Recent Patents on Anti-infective Drug Discovery
Ji Yeon Hong, Eun Jung Ko, Sun Young Choi, Kapsok Li, A Reum Kim, Jin O Park, Beom Joon Kim
BACKGROUND: Various kinds of functional cosmetics are on the market, although there are a variety of opinions concerning the actual effect. Transdermal microneedle patch has been introduced as a newly developed device for drug delivery through the skin. OBJECTIVE: This study was conducted to verify the face skin improvement effect and safety of a novel cosmetic microneedle patch. METHODS: A total of 84 Korean females finished this prospective clinical trial...
October 7, 2017: Journal of Cosmetic Dermatology
Malte Scholz, Thomas Reske, Femke Böhmer, Anne Hornung, Niels Grabow, Hermann Lang
Periodontitis is one of the most common infectious diseases globally that, if untreated, leads to destruction of the tooth supporting tissues and finally results in tooth loss. Evidence shows that standard procedures as mechanical root cleaning could be supported by further treatment options such as locally applied substances. Due to gingival crevicular fluid flow, substances are commonly washed out off the periodontal pockets. The evaluation of administration techniques and the development of local drug releasing devices is thus an important aspect in periodontal research...
2017: PloS One
Iffat Zareen Ahmad, Mohammad Kuddus, Asad Ahmad, Heena Tabassum, Abdul Mabood
Nanostructured material is a solid material with at least one dimension in the nanoscale range. Desired control of the properties and effects of nanostructures can invent new devices and technologies, as the physical and chemical properties of nanostructures are distinctly different from those of a single atom or its bulk phase. This difference in the properties is due to different spatial structures and shapes, phase changes, energetics, electronic structure, chemical reactivity, and catalytic properties of large, finite systems, and their assemblies...
October 2, 2017: Current Drug Metabolism
Ashwin Narain, Simran Asawa, Vikesh Chhabria, Yogita Patil-Sen
Cell membrane coated nanoparticles (NPs) is a biomimetic strategy developed to engineer therapeutic devices consisting of a NP core coated with membrane derived from natural cells such as erythrocytes, white blood cells, cancer cells, stem cells, platelets or bacterial cells. These biomimetic NPs have gained a lot of attention recently owing to their cell surface mimetic features and tailored nanomaterial characteristics. They have shown strong potential in diagnostic and therapeutic applications including those in drug delivery, immune modulation, vaccination and detoxification...
October 2, 2017: Nanomedicine
Sean J Nagel, Chandan G Reddy, Leonardo A Frizon, Marshall T Holland, Andre G Machado, George T Gillies, Matthew A Howard
INTRODUCTION: The intrathecal space remains underutilized for diagnostic testing, invasive monitoring or as a pipeline for the delivery of neurological therapeutic agents and devices. The latter including drug infusions, implants for electrical modulation, and a means for maintaining the physiologic pressure column. The reasons for this are many but include unfamiliarity with the central nervous system and the historical risks that continue to overshadow the low complication rates in modern clinical series...
September 29, 2017: Neuromodulation: Journal of the International Neuromodulation Society
Michael Schiff, Shane Saunderson, Irina Mountian, Paul Hartley
INTRODUCTION: Drug administration by self-injection provides an option to treat chronic inflammatory diseases such as rheumatoid arthritis (RA) and Crohn's disease (CD). However, a negative self-injection experience for patients may reduce patient adherence to the recommended treatment regimen. In this study, a holistic approach was used to identify common themes along the treatment pathway and at self-injection that, if changed, could improve patient experience and treatment outcomes...
September 27, 2017: Rheumatology and Therapy
Vivek T Rathod, Debiprosad Roy Mahapatra
This paper presents the design optimization of diaphragms for a micro-shock tube-based drug delivery device. The function of the diaphragm is to impart the required velocity and direction to the loosely held drug particles on the diaphragm through van der Waals interaction. The finite element model-based studies involved diaphragms made up of copper, brass and aluminium. The study of the influence of material and geometric parameters serves as a vital tool in optimizing the magnitude and direction of velocity distribution on the diaphragm surface...
March 14, 2017: Bioengineering
Berk Gonenc, Jeremy Chae, Peter Gehlbach, Russell H Taylor, Iulian Iordachita
Retinal vein cannulation is a technically demanding surgical procedure where therapeutic agents are injected into the retinal veins to treat occlusions. The clinical feasibility of this approach has been largely limited by the technical challenges associated with performing the procedure. Among the challenges to successful vein cannulation are identifying the moment of venous puncture, achieving cannulation of the micro-vessel, and maintaining cannulation throughout drug delivery. Recent advances in medical robotics and sensing of tool-tissue interaction forces have the potential to address each of these challenges as well as to prevent tissue trauma, minimize complications, diminish surgeon effort, and ultimately promote successful retinal vein cannulation...
September 23, 2017: Sensors
N Battula, V Menezes, S Bhalekar, S H Bhalekar, S M Nejad, H Hosseini
A needle-free vaccine/drug injector that works by virtue of the impulse of a moving shock wave is presented in this communication. The device can deliver controlled micro-volumes of liquid vaccines into skin and soft tissue targets in human with minimal invasion. The operation of the injector was investigated by delivering a dyed liquid into human skin samples and soft tissue models. The depth of penetration of the liquid was examined by histology of the targeted human skin samples. The delivery mechanics and the depth of penetration were analyzed theoretically with an elastic model for the skin and a viscoelastic model for the soft tissue targets, and a good agreement with experiments was observed...
September 15, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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