keyword
MENU ▼
Read by QxMD icon Read
search

Drug delivery devices

keyword
https://www.readbyqxmd.com/read/29239680/the-spots-system-an-ocular-scoring-system-optimized-for-use-in-modern-preclinical-drug-development-and-toxicology
#1
Joshua Seth Eaton, Paul E Miller, Ellison Bentley, Sara M Thomasy, Christopher J Murphy
PURPOSE: To present a semiquantitative ocular scoring system comprising elements and criteria that address many of the limitations associated with systems commonly used in preclinical studies, providing enhanced cross-species applicability and predictive value in modern ocular drug and device development. METHODS: Revisions to the ocular scoring systems of McDonald-Shadduck and Hackett-McDonald were conducted by board-certified veterinary ophthalmologists at Ocular Services On Demand (OSOD) over the execution of hundreds of in vivo preclinical ocular drug and device development studies and general toxicological investigations...
December 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29237363/incorporation-of-an-n-methyl-amino-acid-into-a-template-peptide-alters-anisotropy-in-the-crystal-growth-of-gold-nanoparticles-synthesized-by-the-peptide-template-method
#2
Kin-Ya Tomizaki, Ryuuichi Nanbu, Makoto Kasuga, Takahito Imai
Gold nanocrystals hold promise for use as catalysts and in photonic/plasmonic devices, electronics, sensing/imaging systems, drug delivery systems, and photothermal therapies due to their unique physical, chemical, and biocompatible properties. Various organic templates have been used to control of the size, shape, structure, surface modification and topology of gold nanocrystals. The synthesis of gold nanorods currently requires a cytotoxic surfactant to control morphology. To control the shape of gold nanocrystals, we previously demonstrated the de novo design and synthesis of a b-sheet-forming nonapeptide (RU006: Ac-AIAKAXKIA-NH2, X = L-2-naphthylalanine, Nal)...
December 13, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29236898/in-vitro-analysis-of-a-local-polymeric-device-as-an-alternative-for-systemic-antibiotics-in-dentistry
#3
Talita Girio Carnaval, Flávia Gonçalves, Marcelo Munhóes Romano, Luiz Henrique Catalani, Marcia Alves Pinto Mayer, Victor Elias Arana-Chávez, Alexander Cassandri Nishida, Thais Claudino Lage, Carlos Eduardo Francci, Carlos Alberto Adde
The development of a biodegradable material with antimicrobial properties for local applications is required in the prevention and treatment of infectious diseases. The objective of this study was to produce blends of poly-L-lactide acid (PLLA) synthetic polymer associated with several antimicrobials, as an alternative in the prevention and treatment of infections, as well as to evaluate its cytotoxicity, release of antimicrobials and inhibit bacteria growth. Blends of PLLA added with 20% Amoxicillin, Metronidazole, Clindamycin or Azithromicyn were used to produce Films (F) or Meshs (M) by casting and electrospinning methods, respectively...
December 7, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29230256/design-and-evaluation-of-a-robotic-device-for-automated-tail-vein-cannulations-in-rodent-models
#4
Alex Fromholtz, Max L Balter, Alvin I Chen, Josh M Leipheimer, Anil Shrirao, Timothy J Maguire, Martin L Yarmush
Preclinical testing in rodent models is a ubiquitous part of modern biomedical research and commonly involves accessing the venous bloodstream for blood sampling and drug delivery. Manual tail vein cannulation is a time-consuming process and requires significant skill and training, particularly since improperly inserted needles can affect the experimental results and study outcomes. In this paper, we present a miniaturized, robotic medical device for automated, image-guided tail vein cannulations in rodent models...
December 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29227279/drug-eluting-balloon-design-technology-and-clinical-aspects
#5
Meenasree Bukka, Poorna Jyothi Rednam, Mukty Sinha
Drug eluting balloon is a non-stent technology in which an effective homogenous delivery of anti-proliferative drug processed to the vessel wall through inflated balloon. This is done to restore luminal vascularity in order to treat atherosclerosis, in-stent restenosis and reduce risk of late thrombosis without implanting a permanent foreign object. The balloon technology relies on the concept of targeted delivery of drug which helps in rapid healing of vessel wall and prevents the proliferation of smooth muscle cell...
December 11, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29224030/advances-in-fractional-technology-for-skin-rejuvenation-skin-tightening-drug-delivery-and-treating-scars-and-skin-defects
#6
Deirdre Connolly, Laura Schilling, Nazanin Saedi
The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. This has started to change the paradigm of what is considered first-line treatment for scarring and rejuvenation. While originally applied to nonablative lasers, fractionation has now been employed in ablative, quality-switched, picosecond, and novel hybrid fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29221962/drug-delivery-and-tissue-engineering-to-promote-wound-healing-in-the-immunocompromised-host-current-challenges-and-future-directions
#7
Alexander M Tatara, Dimitrios P Kontoyiannis, Antonios G Mikos
As regenerative medicine matures as a field, more promising technologies are being translated from the benchtop to the clinic. However, many of these strategies are designed with otherwise healthy hosts in mind and validated in animal models without other co-morbidities. In reality, many of the patient populations benefiting from drug delivery and tissue engineering-based devices to enhance wound healing also have significant underlying immunodeficiency. Specifically, patients suffering from diabetes, malignancy, human immunodeficiency virus, post organ transplantation, and other compromised states have significant pleotropic immune defects that affect wound healing...
December 5, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29219058/macrophage-targeted-cellular-carriers-for-effective-delivery-of-anti-tubercular-drugs
#8
S Beg, Jaya Agnihotri, Shibhna Singh, Mohammad Wais
Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB).Multi drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised. One third of the world's population is infected with TB. Recently it is estimated around 9.6 million people around the world became sick with TB disease. There were 1.5 million TB-related deaths worldwide. Therefore with the advent in biotechnology and Nano engineering, newly adapted survival molecular mechanism of Mycobacterium tuberculosis, new targets receptors on alveolar macrophages must be explored out for eradication of TB from the globe...
December 7, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29218564/small-angle-scattering-for-pharmaceutical-applications-from-drugs-to-drug-delivery-systems
#9
Aaron Alford, Veronika Kozlovskaya, Eugenia Kharlampieva
The sub-nanometer scale provided by small angle neutron and X-ray scattering is of special importance to pharmaceutical and biomedical investigators. As drug delivery devices become more functionalized and continue decreasing in size, the ability to elucidate details on size scales smaller than those available from optical techniques becomes extremely pertinent. Information gathered from small angle scattering therefore aids the endeavor of optimizing pharmaceutical efficacy at its most fundamental level. This chapter will provide some relevant examples of drug carrier technology and how small angle scattering (SAS) can be used to solve their mysteries...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#10
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29215787/miniaturized-battery-free-optofluidic-systems-with-potential-for-wireless-pharmacology-and-optogenetics
#11
Kyung Nim Noh, Sung Il Park, Raza Qazi, Zhanan Zou, Aaron D Mickle, Jose G Grajales-Reyes, Kyung-In Jang, Robert W Gereau, Jianliang Xiao, John A Rogers, Jae-Woong Jeong
Combination of optogenetics and pharmacology represents a unique approach to dissect neural circuitry with high specificity and versatility. However, conventional tools available to perform these experiments, such as optical fibers and metal cannula, are limited due to their tethered operation and lack of biomechanical compatibility. To address these issues, a miniaturized, battery-free, soft optofluidic system that can provide wireless drug delivery and optical stimulation for spatiotemporal control of the targeted neural circuit in freely behaving animals is reported...
December 7, 2017: Small
https://www.readbyqxmd.com/read/29210562/methacrylate-stitched-%C3%AE-cyclodextrin-embedded-with-nanogold-nanotitania-a-skin-adhesive-device-for-enhanced-transdermal-drug-delivery
#12
Thayyath Sreenivasan Anirudhan, Syam S Nair, Athira V Sasidharan
Transdermal (TD) drug delivery is an attractive technique for drug delivery compared to oral and intravenous injection. However the permeation of drug molecules across the skin is difficult due to the presence of highly ordered lipid barrier. This investigation details the development of a novel TD system, which has the potential to simultaneously enhance the skin permeability and adhesion behavior. Ibuprofen (IP) was selected as model drug. The ability of gold nanoparticle (AuNP) and hydrophobic titanium nanotube (TNT) to enhance the skin permeability was explored...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29210475/a-rational-approach-to-metal-loading-of-organic-multi-site-polymers-illusion-or-reality
#13
Claude Piguet, Lucille Babel, Karine Baudet, Thi Nu Y Hoang, Homayoun Nozary
Since its identification as an independent topic after the first world war, the chemistry of (bio)polymers and macromolecules rapidly benefited from intense synthetic activities driven by contributors focussing on formulation and structural aspects. Satisfying rationalization and predictions concerning polymer organization, stability and reactivity were however delayed until the late fifties, when physical chemists set the basis of an adapted thermodynamic modelling. The recent emergence of metal-containing (bio)organic polymers (i...
December 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29210318/inhalation-device-options-for-the-management-of-chronic-obstructive-pulmonary-disease
#14
Michael DePietro, Ileen Gilbert, Lauren A Millette, Michael Riebe
Chronic obstructive pulmonary disease (COPD) is characterized by chronic respiratory symptoms and airflow limitation, resulting from abnormalities in the airway and/or damage to the alveoli. Primary care physicians manage the healthcare of a large proportion of patients with COPD. In addition to determining the most appropriate medication regimen, which usually includes inhaled bronchodilators with or without inhaled corticosteroids, physicians are charged with optimizing inhalation device selection to facilitate effective drug delivery and patient adherence...
December 5, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29208293/mesoporous-silica-based-bioactive-glasses-for-antibiotic-free-antibacterial-applications
#15
REVIEW
Seray Kaya, Mark Cresswell, Aldo R Boccaccini
Bioactive glasses (BGs) are being used in several biomedical applications, one of them being as antibacterial materials. BGs can be produced via melt-quenching technique or sol-gel method. Bactericidal silver-doped sol-gel derived mesoporous silica-based bioactive glasses were reported for the first time in 2000, having the composition 76SiO2-19CaO-2P2O5-3Ag2O (wt%) and a mean pore diameter of 28nm. This review paper discusses studies carried out exploring the potential antibacterial applications of drug-free mesoporous silica-based BGs...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29206310/ease-of-fill-port-access-during-the-ultrasound-guided-vs-the-blind-refill-technique-of-intrathecal-drug-delivery-systems-with-a-raised-septum-a-prospective-comparison-study
#16
Paolo Maino, Sander M J van Kuijk, Roberto S G M Perez, Eva Koetsier
OBJECTIVES: The localization of the reservoir fill port of Intrathecal Drug Delivery Devices (IDDS) can be difficult. The purpose of this study was to assess the ease of fill port access during the ultrasound-guided refill technique compared to the blind refill technique in IDDSs with a raised septum on the pump surface. MATERIALS AND METHODS: Written informed consent was obtained from 19 adult patients undergoing regular refills of their Raised Septum IDDSs (RS-IDDSs)...
December 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29204923/novel-drug-delivery-systems-devices-and-fabrication-methods
#17
EDITORIAL
Vivek Agrahari
No abstract text is available yet for this article.
December 4, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29197631/pulmonary-drug-delivery-to-older-people
#18
Martin Wallin, Tatsuaki Tagami, Lan Chen, Mingshi Yang, Hak-Kim Chan
Pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are common in older people. Treatment principles are well established in this group of patients; however, inadequate training and improper inhaler techniques often results in poor treatment outcomes. Healthcare professionals often do not have the required knowledge about the most common inhaler devices. Age-related conditions like cognitive ability and physical strength would also impact on the inhaler usage. Pharmacokinetics and pharmacodynamics may be affected by physiological changes, like impaired renal and hepatic functions and reduced lung functions...
November 29, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29189122/synthetic-polymer-based-electrospun-fibers-biofunctionalization-strategies-and-recent-advances-in-tissue-engineering-drug-delivery-and-diagnostics-vincent-pertici
#19
Vincent Pertici, Guillaume Martrou, Didier Gigmes, Thomas Trimaille
BACKGROUND: Over the last decades, synthetic polymer-based electrospun nano/microfibers have emerged as potent materials in crucial biomedical applications such as tissue engineering, drug delivery and diagnostics. This is mainly attributed to versatility and reproducibility of the electrospinning (ES) process, as well as the high surface-to-volume ratio of the generated nanostructures. Appropriate functionalization with dedicated biomolecules (i.e. cell adhesive peptides, therapeutic molecules, bio-probes) is a critical requirement for the performances of such materials in their related application...
November 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29182626/understanding-the-formation-mechanism-of-lipid-nanoparticles-in-microfluidic-devices-with-chaotic-micromixers
#20
Masatoshi Maeki, Yuka Fujishima, Yusuke Sato, Takao Yasui, Noritada Kaji, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Hideyoshi Harashima, Manabu Tokeshi
Lipid nanoparticles (LNPs) or liposomes are the most widely used drug carriers for nanomedicines. The size of LNPs is one of the essential factors affecting drug delivery efficiency and therapeutic efficiency. Here, we demonstrated the effect of lipid concentration and mixing performance on the LNP size using microfluidic devices with the aim of understanding the LNP formation mechanism and controlling the LNP size precisely. We fabricated microfluidic devices with different depths, 11 μm and 31 μm, of their chaotic micromixer structures...
2017: PloS One
keyword
keyword
61912
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"