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https://www.readbyqxmd.com/read/29453535/toxicity-of-metal-oxide-nanoparticles
#1
Koyeli Girigoswami
In the recent times, nanomaterials are used in many sectors of science, medicine and industry, without revealing its toxic effects. Thus, it is in urgent need for exploring the toxicity along with the application of such useful nanomaterials. Nanomaterials are categorized with a particle size of 1-100 nm. They have gained increasing attention because of their novel properties, including a large specific surface area and high reaction activity. The various fundamental and practical applications of nanomaterials include drug delivery, cell imaging, and cancer therapy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452560/health-care-efficiencies-consolidation-and-alternative-models-vs-health-care-and-antitrust-regulation-irreconcilable-differences
#2
Michael W King
Despite the U.S. substantially outspending peer high income nations with almost 18% of GDP dedicated to health care, on any number of statistical measurements from life expectancy to birth rates to chronic disease, 1 the U.S. achieves inferior health outcomes. In short, Americans receive a very disappointing return on investment on their health care dollars, causing economic and social strain. 2 Accordingly, the debates rage on: what is the top driver of health care spending? Among the culprits: poor communication and coordination among disparate providers, paperwork required by payors and regulations, well-intentioned physicians overprescribing treatments, drugs and devices, outright fraud and abuse, and medical malpractice litigation...
November 2017: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/29452142/in-vitro-in-vivo-evaluation-of-an-oral-ghost-drug-delivery-device-for-the-delivery-of-salmon-calcitonin
#3
Angus R Hibbins, Mershen Govender, Sunaina Indermun, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Viness Pillay
An orally administered site-specific Oral Ghost Drug Delivery (OGDD) Device was developed and evaluated for the administration of salmon calcitonin. In vitro drug release studies have been undertaken using biorelevant media as well as aspirated gastrointestinal fluid from a Large White pig in addition to characterization of a formulated trimethyl chitosan blend formulated and prepared into a loaded mini-pellet system. In vivo drug release analysis in a Large White pig model has further been undertaken on the OGDD device and a commercial intramuscular injection to ascertain the release properties of the OGDD device in an animal model in comparison with the currently used treatment option for the administration of salmon calcitonin...
February 13, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29451844/pulmonary-delivery-of-therapeutic-and-diagnostic-gases
#4
Warren M Zapol, H Cecil Charles, Andrew R Martin, Rui C Sá, Binglan Yu, Fumito Ichinose, Neil MacIntyre, Joseph Mammarappallil, Richard Moon, John Z Chen, Eric T Geier, Chantal Darquenne, G Kim Prisk, Ira Katz
The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseous drugs in many cases targets the same therapeutic areas as aerosol drug delivery, and is in many scientific and technical aspects similar to aerosol drug delivery. This article serves as a report on the recent ISAM congress session providing a synopsis of each of the presentations...
February 16, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29451021/the-uva-padova-type-1-diabetes-simulator-goes-from-single-meal-to-single-day
#5
Roberto Visentin, Enrique Campos-Náñez, Michele Schiavon, Dayu Lv, Martina Vettoretti, Marc Breton, Boris P Kovatchev, Chiara Dalla Man, Claudio Cobelli
BACKGROUND: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is presented which provides a more realistic testing scenario. The upgrades to the previous simulator, which was accepted by the Food and Drug Administration in 2013, are described. METHOD: Intraday variability of insulin sensitivity (S I ) has been modeled, based on clinical T1D data, accounting for both intra- and intersubject variability of daily S I . Thus, time-varying distributions of both subject's basal insulin infusion and insulin-to-carbohydrate ratio were calculated and made available to the user...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29450404/reengineering-deep-brain-stimulation-for-movement-disorders-emerging-technologies
#6
Aysegul Gunduz, Kelly D Foote, Michael S Okun
Deep brain stimulation (DBS) is a neurosurgical technique, which consists of continuous delivery of an electrical pulse through chronically implanted electrodes connected to a neurostimulator, programmable in amplitude, pulse width, frequency, and stimulation channel. DBS is a promising treatment option for addressing severe and drug-resistant movement disorders. The success of DBS therapy is a combination of surgical implantation techniques, device technology, and clinical programming strategies. Changes in device settings require highly trained and experienced clinicians to achieve maximal therapeutic benefit for each targeted symptom, and optimization of stimulation parameters can take many visits...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29446742/development-of-an-in-vitro-drug-delivery-efficiency-test-for-a-pulmonary-toxicokinetic-pig-study
#7
Nadine Schaefer, Ann-Katrin Kroll, Matthias W Laschke, Michael D Menger, Hans H Maurer, Markus R Meyer, Peter H Schmidt
BACKGROUND: Since their appearance on the drugs of abuse market, synthetic cannabinoids (SCs) are gaining increasing toxicological relevance. They are consumed without knowledge of their toxicokinetic (TK) and toxicodynamic properties and human studies are not allowed due to ethical reasons. A controlled animal TK study following nebulization of 4-ethylnaphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-210), 2-(4-methoxyphenyl)-1-(1-pentyl-indole-3-yl)methanone (RCS-4) as well as Δ9-tetrahydrocannabinol (THC) to pigs should be helpful for better interpretation of analytical results in cases of misuse or poisoning...
February 14, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29443901/toxicology-of-engineered-nanoparticles-focus-on-poly-amidoamine-dendrimers
#8
REVIEW
Pratap C Naha, Sourav P Mukherjee, Hugh J Byrne
Engineered nanomaterials are increasingly being developed for paints, sunscreens, cosmetics, industrial lubricants, tyres, semiconductor devices, and also for biomedical applications such as in diagnostics, therapeutics, and contrast agents. As a result, nanomaterials are being manufactured, transported, and used in larger and larger quantities, and potential impacts on environmental and human health have been raised. Poly(amidoamine) (PAMAM) dendrimers are specifically suitable for biomedical applications...
February 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29441934/implants-composed-of-digoxin-and-poly-%C3%AE%C2%B5-caprolactone-development-characterization-anti-proliferative-and-anti-angiogenic-activities
#9
F F Rodrigues, W R Braz, F B Perasoli, L G R Ferreira, L A de O Barbosa, G R Da Silva
Drug delivery systems could be applied to locally treat cervical cancer, thus preventing the drawbacks of conventional therapy. In this study, anti-proliferative and anti-angiogenic effects of digoxin incorporated into poly(ε-caprolactone) implants were evaluated, aiming at the local treatment of cervical cancer. Implants were characterized, and the in vitro release profile of digoxin was demonstrated. Anti-proliferative and anti-angiogenic activities of digoxin were investigated by using chorioallantoic membrane and human cervix carcinoma (HeLa) cells, respectively...
July 3, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440702/a-fluidic-device-for-the-controlled-formation-and-real-time-monitoring-of-soft-membranes-self-assembled-at-liquid-interfaces
#10
Arturo Mendoza-Meinhardt, Lorenzo Botto, Alvaro Mata
Membrane materials formed at the interface between two liquids have found applications in a large variety of technologies, from sensors to drug-delivery and catalysis. However, studying the formation of these membranes in real-time presents considerable challenges, owing to the difficulty of prescribing the location and instant of formation of the membrane, the difficulty of observing time-dependent membrane shape and thickness, and the poor reproducibility of results obtained using conventional mixing procedures...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439396/functional-magnetic-mesoporous-silica-microparticles-capped-with-an-azo-derivative-a-promising-colon-drug-delivery-device
#11
Adrián H Teruel, Carmen Coll, Ana M Costero, Daniel Ferri, Margarita Parra, Pablo Gaviña, Marta González-Álvarez, Virginia Merino, M Dolores Marcos, Ramón Martínez-Máñez, Félix Sancenón
Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1 . Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold...
February 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29438327/carbon-based-nanomaterials-allotropes-a-glimpse-of-their-synthesis-properties-and-some-applications
#12
REVIEW
Salisu Nasir, Mohd Zobir Hussein, Zulkarnain Zainal, Nor Azah Yusof
Carbon in its single entity and various forms has been used in technology and human life for many centuries. Since prehistoric times, carbon-based materials such as graphite, charcoal and carbon black have been used as writing and drawing materials. In the past two and a half decades or so, conjugated carbon nanomaterials, especially carbon nanotubes, fullerenes, activated carbon and graphite have been used as energy materials due to their exclusive properties. Due to their outstanding chemical, mechanical, electrical and thermal properties, carbon nanostructures have recently found application in many diverse areas; including drug delivery, electronics, composite materials, sensors, field emission devices, energy storage and conversion, etc...
February 13, 2018: Materials
https://www.readbyqxmd.com/read/29436817/protective-layer-development-for-enhancing-stability-and-drug-delivery-capabilities-of-des-surface-crystallized-coatings
#13
Shady Farah
Carrier-free drug eluting stents (DES) based crystalline coatings are gaining prominence due to their function, skipping many limitations and clinical complications of the currently marketed DES. However, their usage has been humbled by crystalline coating inflexibility, limited mechanical and physical properties. This study reports for the first time a protective top coating development for enhancing crystalline coating merits and delivery capabilities. Flexible and water soluble polysaccharide top coating was developed and applied onto Rapamycin (RM) crystalline carpet...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29432400/treatment-of-coronary-artery-disease-with-a-new-generation-drug-coated-balloon-final-results-of-the-italian-elutax-sv-registry-dcb-rise
#14
Bernardo Cortese, Fabrizio D'Ascenzo, Raffaela Fetiveau, Vruyr Balian, Simonetta Blengino, Massimo Fineschi, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Maurizio D'Amico, Arnaldo Poli, Gaetano Di Palma, Roberto A Latini, Pedro S Orrego, Romano Seregni
AIMS: Drug-coated balloons (DCBs) are a recognized alternative to stents for the treatment of in-stent restenosis (ISR), and there is some initial clinical evidence about their efficacy for the treatment of small coronary vessels. Newer-generation DCBs were developed to overcome the reduced deliverability of the previous generation, also warranting a more effective drug delivery to vessel wall. However, the vast majority of new-generation DCBs still lack of reliability due to paucity of clinical data...
February 9, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29429663/mechanically-robust-dual-responsive-water-dispersible-graphene-based-conductive-elastomeric-hydrogel-for-tunable-pulsatile-drug-release
#15
Sayan Ganguly, Debes Ray, Poushali Das, Priti Prasanna Maity, Subhadip Mondal, V K Aswal, Santanu Dhara, Narayan Ch Das
Nanohybrid hydrogels based on pristine graphene with enhanced toughness and dual responsive drug delivery feature is opening a new era for smart materials. Here pristine graphene hydrogels are synthesized by in situ free radical polymerization where graphene platelets are the nanobuiliding blocks to withstand external stress and shows reversible ductility. Such uniqueness is a mere reflection of rubber-like elasticity on the hydrogels. These nanobuilding blocks serve also the extensive physisorption which enhances the physical crosslinking inside the gel matrix...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29425763/buccal-drug-delivery-technologies-for-patient-centred-treatment-of-radiation-induced-xerostomia-dry-mouth
#16
REVIEW
Osamah S Malallah, Cristina M Aller Garcia, Gordon B Proctor, Ben Forbes, Paul G Royall
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. Patients with xerostomia suffer symptoms that severely affect their health as well as physical, social and emotional aspects of their life. The current management of xerostomia is the application of saliva substitutes or systemic delivery of saliva-stimulating cholinergic agents, including pilocarpine, cevimeline or bethanechol tablets...
February 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29424290/industry-update-what-is-new-in-the-field-of-therapeutic-delivery
#17
Elaine Harris
The present industry update covers the period 1-30 November 2017. Sources of information include company press releases, regulatory and patent agencies' notices, scientific literature and various news websites. A number of companies reported positive clinical trial results for therapeutic candidates enabled by different delivery strategies including Vascular Therapies, Adapt and Altemia. November also saw the announcement of some significant collaborations and acquisitions; Cerenis Therapeutics acquired Lypro Biosciences, which gives them access to a proprietary drug delivery nanotechnology platform, NanoDisk ® , and Takeda announced a collaboration with Portal Instruments to develop a needle-free delivery device for its biological therapeutics...
February 1, 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29421608/defining-drug-and-target-protein-distributions-after-stent-based-drug-release-durable-versus-deployable-coatings
#18
Abraham R Tzafriri, Fernando Garcia-Polite, Xiaojian Li, John Keating, Josep-Maria Balaguer, Brett Zani, Lynn Bailey, Peter Markham, Timothy C Kiorpes, Wenda Carlyle, Elazer R Edelman
BACKGROUND: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial definition of drug, receptor binding and cell state. METHODS: Two designs of sirolimus analog eluting stents were implanted into porcine coronary arteries for 28, 60 or 90 days (n = 9/time point), durable coating (Xience) and deployable absorbable coating (MiStent). Explanted arteries were evaluated for drug content (n = 3/time point) by LC-MS/MS and for drug and target protein (mTOR) distributions by immunofluorescence (IF, n = 6/time point)...
February 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29418076/viral-based-nanomaterials-for-plasmonic-and-photonic-materials-and-devices
#19
REVIEW
Dan Stefan Petrescu, Amy Szuchmacher Blum
Over the last decade, viruses have established themselves as a powerful tool in nanotechnology. Their proteinaceous capsids benefit from biocompatibility, chemical addressability, and a variety of sizes and geometries, while their ability to encapsulate, scaffold, and self-assemble enables their use for a wide array of purposes. Moreover, the scaling up of viral-based nanotechnologies is facilitated by high capsid production yield and speed, which is particularly advantageous when compared with slower and costlier lithographic techniques...
February 8, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29416447/a-microfluidic-device-for-the-delivery-of-enzymes-into-cells-by-liposome-fusion
#20
Phillip Kuhn, Klaus Eyer, Petra S Dittrich
Liposomes are versatile carriers of drugs or biomolecules and are ideally suited to transport molecules into cells. However, mechanistic studies to understand and improve the fusion of liposomes with cell membranes and endosomes are difficult. Here, we report a method that allows for stable coimmobilization of liposomes and living cells, thereby bringing the membranes into close contact, which is essential for membrane fusion. The small unilamellar liposomes are tethered to the surface by a linker so that no modification of the liposome membrane for cell binding is required...
February 2018: Engineering in Life Sciences
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