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Drug delivery devices

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https://www.readbyqxmd.com/read/28735415/cfd-simulation-of-aerosol-delivery-to-a-human-lung-via-surface-acoustic-wave-nebulization
#1
Morteza Yousefi, Oveis Pourmehran, Mofid Gorji-Bandpy, Kiao Inthavong, Leslie Yeo, Jiyuan Tu
Administration of drug in the form of particles through inhalation is generally preferable in the treatment of respiratory disorders. Conventional inhalation therapy devices such as inhalers and nebulizers, nevertheless, suffer from low delivery efficiencies, wherein only a small fraction of the inhaled drug reaches the lower respiratory tract. This is primarily because these devices are not able to produce a sufficiently fine drug mist that has aerodynamic diameters on the order of a few microns. This study employs computational fluid dynamics to investigate the transport and deposition of the drug particles produced by a new aerosolization technique driven by surface acoustic waves (SAWs) into an in silico lung model geometrically reconstructed using computed tomography scanning...
July 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28730936/an-industry-update-what-is-the-latest-news-in-therapeutic-delivery
#2
Iain Simpson
This Industry Update covers the period from 1 through 30 April 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. Biogen expanded its portfolio of developmental drugs targeting neurological diseases by licensing a drug from Bristol-Myers Squibb which is currently under investigation for the treatment of progressive supranuclear palsy. Takeda announced a deal with NuBiyota focused on developing treatments for gastrointestinal disorders, based on the manipulation of microbes living in the gut...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730933/drug-delivery-to-the-lungs-challenges-and-opportunities
#3
Stephen P Newman
Pulmonary drug delivery is relatively complex because the respiratory tract has evolved defense mechanisms to keep inhaled drug particles out of the lungs and to remove or inactivate them once deposited. In addition to these mechanical, chemical and immunological barriers, pulmonary drug delivery is adversely affected by the behavioral barriers of poor adherence and poor inhaler technique. Strategies to mitigate the effects of these barriers include use of inhaler devices and formulations that deliver drug to the lungs efficiently, appropriate inhaler technique and improved education of patients...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28722038/promises-facts-and-challenges-for-graphene-in-biomedical-applications
#4
Giacomo Reina, José Miguel González-Domínguez, Alejandro Criado, Ester Vázquez, Alberto Bianco, Maurizio Prato
The graphene family has captured the interest and the imagination of an increasing number of scientists working in different fields, ranging from composites to flexible electronics. In the area of biomedical applications, graphene is especially involved in drug delivery, biosensing and tissue engineering, with strong contributions to the whole nanomedicine area. Besides the interesting results obtained so far and the evident success, there are still many problems to solve, on the way to the manufacturing of biomedical devices, including the lack of standardization in the production of the graphene family members...
July 19, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28718777/an-assembly-and-interaction-of-upconversion-and-plasmonic-nanoparticles-on-organometallic-nanofibers-enhanced-multicolor-upconversion-downshifting-emission-and-plasmonic-effect
#5
Priyam Singh, Praveen Kumar Shahi, Rajiv Prakash, S B Rai
We herein present a novel inorganic-organic hybrid nanoparticle (HNPs) constituted of inorganic NPs, NaY0.78Er0.02Yb0.2F4, and organometallic nanofiber, Tb(ASA)3Phen (TAP). The X-ray diffraction, Fourier transform infrared absorption and TEM analyse reveal that, the prepared ultrafine upconversion nanoparticles {UCNPs (6-9 nm)} are dispersed on the surface of TAP nanofibers. We observe that addition of TAP in UCNPs, effectively prevents the surface quenching to boost the UC intensity and enables tuning of UC emission from green to red region by controlling the phonon frequency around Er3+ ion...
July 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28718049/good-things-in-small-packages-an-innovative-delivery-approach-for-inhaled-insulin
#6
James B Fink, Lisa Molloy, John S Patton, Valdecir Castor Galindo-Filho, Jacqueline de Melo Barcelar, Luciana Alcoforado, Simone Cristina Soares Brandão, Armèle Dornelas de Andrade
PURPOSE: The design development of a small, hand held, battery operated, breath actuated inhaler as a drug/device platform for inhaled insulin posed a number of technical challenges. Our goal was to optimize lung deposition and distribution with aerosol generators producing 3-6 μm particle size distribution. METHODS: In silico modeling with computational fluid dynamics (CFD) and in vitro testing of device components were assessed using an Alberta idealized adult airway (Copley, UK) to optimize mouthpiece and aerosol path design for dose delivered distal to the trachea...
July 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28715515/surgical-suture-releasing-macrophage-targeted-drug-loaded-nanoparticles-for-an-enhanced-anti-inflammatory-effect
#7
Hansol Kim, Byung Hwi Kim, Beom Kang Huh, Yeon Chun Yoo, Chan Yeong Heo, Young Bin Choy, Ji-Ho Park
A surgical suture is a medical device to close the wound site of skin and organs but excessive inflammation surrounding the suture can disrupt the wound healing process. Although post-operative prescription of anti-inflammatory drugs is used to manage the inflammation, the need for local drug delivery systems has been rising because of low bioavailability and fast clearance of drugs. In this work, we proposed a new strategy for a local anti-inflammatory device by incorporating macrophage-targeted anti-inflammatory nanoparticles into the suture...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28714269/impermeable-robust-hydrogels-via-hybrid-lamination
#8
German A Parada, Hyunwoo Yuk, Xinyue Liu, Alex J Hsieh, Xuanhe Zhao
Hydrogels have been proposed for sensing, drug delivery, and soft robotics applications, yet most of these materials suffer from low mechanical robustness and high permeability to small molecules, limiting their widespread use. This study reports a general strategy and versatile method to fabricate robust, highly stretchable, and impermeable hydrogel laminates via hybrid lamination of an elastomer layer bonded between hydrogel layers. By controlling the layers' composition and thickness, it is possible to tune the stiffness of the impermeable hydrogels without sacrificing the stretchability...
July 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28714139/simple-radical-polymerization-of-poly-alginate-graft-n-isopropylacrylamide-injectable-thermoresponsive-hydrogel-with-the-potential-for-localized-and-sustained-delivery-of-stem-cells-and-bioactive-molecules
#9
Sreekanth Pentlavalli, Philip Chambers, Binulal N Sathy, Michelle O'Doherty, Marine Chalanqui, Daniel J Kelly, Tammy Haut-Donahue, Helen O McCarthy, Nicholas J Dunne
In this study, thermoresponsive copolymers that are fully injectable, biocompatible, and biodegradable and are synthesized via graft copolymerization of poly(N-isopropylacrylamide) onto alginate using a free-radical reaction are presented. This new synthesis method does not involve multisteps or associated toxicity issues, and has the potential to reduce scale-up difficulties. Chemical and physical analyses verify the resultant graft copolymer structure. The lower critical solution temperature, which is a characteristic of sol-gel transition, is observed at 32 °C...
July 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28714058/in-vitro-and-in-vivo-effects-of-pdgf-bb-delivery-strategies-on-tendon-healing-a-review
#10
O Evrova, J Buschmann
To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury. PDGF-BB promotes mitogenesis and angiogenesis, which could accelerate tendon healing. Therefore, in vitro studies with PDGF-BB have been performed to determine its effect on tenocytes and tenoblasts. Moreover, accurate and sophisticated drug delivery devices, aiming for a sustained release of PDGF-BB, have been developed, either by using heparin-binding and fibrin-based matrices or different electrospinning techniques...
July 17, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28710006/drug-eluting-embolic-microspheres-for-local-drug-delivery-state-of-the-art
#11
REVIEW
Katrin Fuchs, R Duran, Alban Denys, Pierre E Bize, Gerrit Borchard, Olivier Jordan
Embolic microspheres or beads used in transarterial chemoembolization are an established treatment method for hepatocellular carcinoma patients. The occlusion of the tumor-feeding vessels by intra-arterial injection of the beads results in tumor necrosis and shrinkage. In this short review, we describe the utility of using these beads as devices for local drug delivery. We review the latest advances in the development of non-biodegradable and biodegradable drug-eluting beads for transarterial chemoembolization...
July 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28708066/novel-selective-detection-method-of-tumor-angiogenesis-factors-using-living-nano-robots
#12
Mohamed Al-Fandi, Nida Alshraiedeh, Rami Owies, Hala Alshdaifat, Omamah Al-Mahaseneh, Khadijah Al-Tall, Rawan Alawneh
This paper reports a novel self-detection method for tumor cells using living nano-robots. These living robots are a nonpathogenic strain of E. coli bacteria equipped with naturally synthesized bio-nano-sensory systems that have an affinity to VEGF, an angiogenic factor overly-expressed by cancer cells. The VEGF-affinity/chemotaxis was assessed using several assays including the capillary chemotaxis assay, chemotaxis assay on soft agar, and chemotaxis assay on solid agar. In addition, a microfluidic device was developed to possibly discover tumor cells through the overexpressed vascular endothelial growth factor (VEGF)...
July 14, 2017: Sensors
https://www.readbyqxmd.com/read/28707332/conjugated-polymer-for-voltage-controlled-release-of-molecules
#13
Shenghua Liu, Ying Fu, Guijun Li, Li Li, Helen Ka-Wai Law, Xianfeng Chen, Feng Yan
Conjugated polymers are attractive in numerous biological applications because they are flexible, biocompatible, cost-effective, solution-processable, and electronic/ionic conductive. One interesting application is for controllable drug release, and this has been realized previously using organic electronic ion pumps. However, organic electronic ion pumps show high operating voltages and limited transportation efficiency. Here, the first report of low-voltage-controlled molecular release with a novel organic device based on a conjugated polymer poly(3-hexylthiophene) is presented...
July 14, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28707164/optimizing-the-bioavailability-of-subcutaneously-administered-biotherapeutics-through-mechanochemical-drivers
#14
REVIEW
D S Collins, L C Kourtis, N R Thyagarajapuram, R Sirkar, S Kapur, M W Harrison, D J Bryan, G B Jones, J M Wright
The subcutaneous route offers myriad benefits for the administration of biotherapeutics in both acute and chronic diseases, including convenience, cost effectiveness and the potential for automation through closed-loop systems. Recent advances in parenteral administration devices and the use of additives which enhance drug dispersion have generated substantial additional interest in IV to SQ switching studies. Designing pre-clinical and clinical studies using SQ mediated delivery however requires deep understanding of complex inter-related physiologies and transport pathways governing the interstitial matrix, vascular system and lymphatic channels...
July 13, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28696529/fast-dynamic-visualizations-in-microfluidics-enabled-by-fluorescent-carbon-nanodots
#15
Yi Huang, Lian Xiao, Tingting An, Wenxiang Lim, Teckneng Wong, Handong Sun
Microfluidic systems have become a superior platform for explorations of fascinating fluidic physics at microscale as well as applications in biomedical devices, chemical reactions, drug delivery, etc. Exploitations of this platform are built upon the fundamental techniques of flow visualizations. However, the currently employed fluorescent materials for microfluidic visualization are far from satisfaction, which severely hinders their widespread applications. Here fluorescent carbon nanodots are documented as a game-changer, applicable in versatile fluidic environment for the visualization in microfluidics with unprecedented advantages...
July 11, 2017: Small
https://www.readbyqxmd.com/read/28693325/transparent-silk-fibroin-microspheres-from-controlled-droplet-dissolution-in-a-binary-solution
#16
Fernando Javita, Xuehua Zhang
Silk is a natural polymer with a broad range of potential applications in textile, advanced materials, biomedical devices and drug delivery. The ability to control the morphology and assembly of silk fibroin is essential for fabrication of silk-based structured materials. Here we report an effective and simple approach based on droplet dissolution for weaving silk fibroin into spheres of several hundred micrometers in diameter. The spheres possess regular wrinkled microstructures on the surface and switchable transparency for visible light...
July 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28691092/instant-tough-bonding-of-hydrogels-for-soft-machines-and-electronics
#17
Daniela Wirthl, Robert Pichler, Michael Drack, Gerald Kettlguber, Richard Moser, Robert Gerstmayr, Florian Hartmann, Elke Bradt, Rainer Kaltseis, Christian M Siket, Stefan E Schausberger, Sabine Hild, Siegfried Bauer, Martin Kaltenbrunner
Introducing methods for instant tough bonding between hydrogels and antagonistic materials-from soft to hard-allows us to demonstrate elastic yet tough biomimetic devices and machines with a high level of complexity. Tough hydrogels strongly attach, within seconds, to plastics, elastomers, leather, bone, and metals, reaching unprecedented interfacial toughness exceeding 2000 J/m(2). Healing of severed ionic hydrogel conductors becomes feasible and restores function instantly. Soft, transparent multilayered hybrids of elastomers and ionic hydrogels endure biaxial strain with more than 2000% increase in area, facilitating soft transducers, generators, and adaptive lenses...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28690136/drug-delivery-devices-for-retinal-diseases
#18
Hirokazu Kaji, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe
Retinal degenerative diseases are a leading cause of irreversible blindness and visual impairment, affecting millions of people worldwide. Although intravitreal injection can directly deliver drugs to the posterior segment of the eye, it is invasive and associated with serious side effects. The design of drug delivery systems targeting the posterior segment of the eye in a less invasive manner has still been challenging because of various anatomical and physiological barriers. In this review, we provide an overview of the current implant device-based approaches used for treating retinal degenerative diseases...
July 6, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28687935/update-of-ablative-fractionated-lasers-to-enhance-cutaneous-topical-drug-delivery
#19
REVIEW
Jill S Waibel, Ashley Rudnick, Deborah R Shagalov, Danielle M Nicolazzo
Ablative fractional lasers (AFXL) enhance uptake of therapeutics and this newly emerging field is called laser-assisted drug delivery (LAD). This new science has emerged over the past decade and is finding its way into clinical practice. LAD is poised to change how medicine delivers drugs. Topical and systemic application of pharmaceutical agents for therapeutic effect is an integral part of medicine. With topical therapy, the stratum corneum barrier of the skin impairs the ability of drugs to enter the body...
July 7, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28675637/nanostructured-mineral-coatings-stabilize-proteins-for-therapeutic-delivery
#20
Xiaohua Yu, Adam H Biedrzycki, Andrew S Khalil, Dalton Hess, Jennifer M Umhoefer, Mark D Markel, William L Murphy
Proteins tend to lose their biological activity due to their fragile structural conformation during formulation, storage, and delivery. Thus, the inability to stabilize proteins in controlled-release systems represents a major obstacle in drug delivery. Here, a bone mineral inspired protein stabilization strategy is presented, which uses nanostructured mineral coatings on medical devices. Proteins bound within the nanostructured coatings demonstrate enhanced stability against extreme external stressors, including organic solvents, proteases, and ethylene oxide gas sterilization...
July 4, 2017: Advanced Materials
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