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Drug delivery devices

Sen Lin, Yi Min Xie, Qing Li, Xiaodong Huang, Zhe Zhang, Guowei Ma, Shiwei Zhou
Being one of the commonest deformation modes for soft matters, shell buckling is the primary reason for the growth and nastic movement of many plants, as well as the formation of complex natural morphology. On-demand regulation of buckling-induced deformation associated with wrinkling, ruffling, folding, creasing and delaminating has profound implications for diverse scopes, which can be seen in its broad applications in microfabrication, 4D printing, actuator and drug delivery. This paper reviews the recent remarkable developments in the shell buckling of soft matters to explain the most representative natural morphogenesis from the perspectives of theoretical analysis in continuum mechanics, finite element analysis, and experimental validations...
June 20, 2018: Bioinspiration & Biomimetics
Corina L Savin, Cristian Peptu, Zuzana Kronekova, Michal Sedlacik, Miroslav Mrlik, Vlasta Sasinkova, Catalina A Peptu, Marcel Popa, Jaroslav Mosnacek
The high interest in polymers from natural resources prompted us to investigate the use of enzymatically synthesized polyglobalide (PGL) in the preparation of polymer networks with potential applications as biomaterials for drug delivery devices. Polymer networks were obtained under mild conditions by photoinitiated thiol-ene coupling between PGL and a poly(ethylene glycol-co-thiomalate) (PEG-SH) copolymer obtained by polycondensation. The obtained polymer networks were thoroughly characterized by Raman spectroscopy, scanning electron microscopy, titration of thiol groups and elemental analysis...
June 19, 2018: Biomacromolecules
Muhammed Anwary, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Viness Pillay
Posterior segment diseases are commonly implicated in the occurrence of curable as well as incurable diseases which could lead to blindness. An example of one such disease is age-related macular degeneration, which would require chronic treatment over an extended period and as such the development of an intravitreal drug delivery system that would optimize patient outcomes is essential. The major contributor of the difficulty in treating diseases in the posterior segment is the structure of the eye, particularly the blood-ocular barriers...
June 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Anna Marie Jilla, Carole E Johnson, Jeffrey L Danhauer
Recently, President Trump signed into law the Food and Drug Administration (FDA) Reauthorization Act of 2017, which included the Over-the-Counter Hearing Aid Act designed to provide greater public accessibility to and affordability of amplification for individuals with self-identified mild and moderate hearing loss through the provision of over-the-counter (OTC) hearing aids (HAs) with a direct-to-consumer (DTC) delivery model. American Speech-Language-Hearing Association and American Academy of Audiology Position Statements on OTC HAs state that these devices should only be used for adults with mild hearing losses...
May 2018: Seminars in Hearing
Marie-Claude Gagnon, Michèle Auger, Jean-François Paquin
The synthesis and biophysical studies of fluorinated phospholipids have attracted a lot of interest over the past 40 years. Mono- and polyfluorinated phospholipids, containing 1-4 fluorine atoms, are designed mostly with the goal of developing new model membranes. The fluorine atoms are herein used as probes, mainly in 19F-NMR spectroscopy, to study biomolecule complexes. In this case, the spectroscopic features of the fluorine atom and the preservation of the parent lipid properties are of primary importance...
June 18, 2018: Organic & Biomolecular Chemistry
James D Byrne, Jen Jen Yeh, Joseph M DeSimone
Despite major advancements in cancer treatments, there are still many limitations to therapy including off-target effects, drug resistance, and control of cancer-related symptoms. There are opportunities for local drug delivery devices to intervene at various stages of cancer to provide curative and palliative benefit. Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer. These devices have shown promise in pre-clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers...
June 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Manabu Tokeshi
No abstract text is available yet for this article.
March 15, 2018: Advanced Drug Delivery Reviews
Edgardo Rivera-Delgado, Ashley Djuhadi, Chaitanya Danda, Jonathan Kenyon, João Maia, Arnold I Caplan, Horst A von Recum
Drug delivery strategies generally use inert materials, such as high molecular weight polymers, to encapsulate and control the release rate of therapeutic drugs. Diffusion governs release and depends on the ease of permeation of the polymer alongside the device thickness. Yet in applications such as osteoarthritis, the physiological constraints and limited intra-articular joint space prevent the use of large, solid drug delivery implants. Other investigators have explored the use of micro- and nanoparticle drug delivery systems...
June 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Guy Steuer, Dario Prais, Huda Mussaffi, Meir Mei-Zahav, Ophir Bar-On, Hagit Levine, Yulia Gendler, Hannah Blau, Patrick Stafler
BACKGROUND: Dry powder inhalers (DPI) are effective but forceful inhalation required to fluidize the powder may be difficult for children and patients with airway disease. Inspiromatic is a new generation active DPI that actively suspends drugs in synchrony with inhalation. We evaluated safety and efficacy of Formoterol delivery via Inspiromatic, compared to Aerolizer, a conventional DPI, in pediatric asthmatic subjects. METHODS: A phase I/II, randomized, single-center, double-blind, double-dummy, placebo-controlled, cross-over study...
June 15, 2018: Pediatric Pulmonology
Hardi Jogi, Rahul Maheshwari, Nidhi Raval, Kaushik Kuche, Vishakha Tambe, Kit-Kay Mak, Mallikarjuna Rao Pichika, Rakesh Kumar Tekade
Cancer is estimated to be a significant health problem of the 21st century. The situation gets even tougher when it comes to its treatment using chemotherapy employing synthetic anticancer molecules with numerous side effects. Recently, there has been a paradigm shift toward the adoption of herbal drugs for the treatment of cancer. In this context, a suitable delivery system is principally warranted to deliver these herbal biomolecules specifically at the tumorous site. To achieve this goal, carbon nanotubes (CNTs) have been widely explored to deliver anticancer herbal molecules with improved therapeutic efficacy and safety...
June 15, 2018: Nanomedicine
Megan A Catterton, Austin F Dunn, Rebecca R Pompano
Many in vivo tissue responses begin locally, yet most in vitro stimuli are delivered globally. Microfluidics has a unique ability to provide focal stimulation to tissue samples with precise control over fluid location, flow rate, and composition. However, previous devices utilizing fixed ports beneath the tissue required manual alignment of the tissue over the ports, increasing the risk of mechanical damage. Here we present a novel microfluidic device that allows the user to define the location of fluid delivery to a living tissue slice without manipulating the tissue itself...
June 15, 2018: Lab on a Chip
Diren Arsoy, Christopher G Salib, William H Trousdale, Meagan E Tibbo, Afton K Limberg, Anthony Viste, Eric A Lewallen, Nicolas Reina, Michael J Yaszemski, Daniel J Berry, Andre J van Wijnen, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew P Abdel
Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC)...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Paul Baek, Lenny Voorhaar, David Barker, Jadranka Travas-Sejdic
The field of bioelectronics involves the fascinating interplay between biology and human-made electronics. Applications such as tissue engineering, biosensing, drug delivery, and wearable electronics require biomimetic materials that can translate the physiological and chemical processes of biological systems, such as organs, tissues. and cells, into electrical signals and vice versa. However, the difference in the physical nature of soft biological elements and rigid electronic materials calls for new conductive or electroactive materials with added biomimetic properties that can bridge the gap...
June 13, 2018: Accounts of Chemical Research
Petteri Parkkila, Mohamed Elderdfi, Alex Bunker, Tapani Viitala
Supported lipid bilayers (SLBs) have been used extensively as an effective model of biological membranes, in the context of in vitro biophysics research, and the membranes of liposomes, in the context of the development of nanoscale drug delivery devices. Despite numerous surface-sensitive techniques having been applied to their study, the comprehensive optical characterization of SLBs using surface plasmon resonance (SPR) has not been conducted. In this study, Fresnel multilayer analysis is utilized to effectively calculate layer parameters (thickness and refractive indices) with the aid of dual-wavelength and dispersion coefficient analysis, in which the linear change in refractive index as a function of wavelength is assumed...
June 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ali K Yetisen, Juan Leonardo Martinez-Hurtado, Barış Ünal, Ali Khademhosseini, Haider Butt
Wearables as medical technologies are becoming an integral part of personal analytics, measuring physical status, recording physiological parameters, or informing schedule for medication. These continuously evolving technology platforms do not only promise to help people pursue a healthier life style, but also provide continuous medical data for actively tracking metabolic status, diagnosis, and treatment. Advances in the miniaturization of flexible electronics, electrochemical biosensors, microfluidics, and artificial intelligence algorithms have led to wearable devices that can generate real-time medical data within the Internet of things...
June 11, 2018: Advanced Materials
Michelly C G Pellá, Michele K Lima-Tenório, Ernandes T Tenório-Neto, Marcos R Guilherme, Edvani C Muniz, Adley F Rubira
The advances in the field of biomaterials have led to several studies on alternative biocompatible devices and to their development focusing on their properties, benefits, limitations, and utilization of alternative resources. Due to their advantages like biocompatibility, biodegradability, and low cost, polysaccharides have been widely used in the development of hydrogels. Among the polysaccharides studied on hydrogels preparation, chitosan (pure or combined with natural/synthetic polymers) have been widely investigated for use in biomedical field...
September 15, 2018: Carbohydrate Polymers
Fahad N Alsunaydih, Jean-Michel Redoute, Mehmet R Yuce
Conventional radiological and endoscopic techniques utilizing long tubes were ineffective in visualizing the small bowel mucosa until the development of wireless capsule endoscopy (WCE). WCE is a revolutionary endoscopic technology that can diagnose the complete gastrointestinal tract. However, the existing capsule technologies are passive, and thus they cannot be navigated to or held in a specific location. The design of an active capsule will present the opportunity to move and stop a device at any targeted locations leading to numerous medical applications such as drug delivery or collecting tissue samples for examinations in the laboratory...
2018: IEEE Journal of Translational Engineering in Health and Medicine
William Ong, Junquan Lin, Marie E Bechler, Kai Wang, Mingfeng Wang, Charles Ffrench-Constant, Sing Yian Chew
Our ability to rescue functional deficits after demyelinating diseases or spinal cord injuries is limited by our lack of understanding of the complex remyelination process, which is crucial to functional recovery. In this study, we developed an electrospun suspended poly(ε-caprolactone) microfiber platform to enable the screening of therapeutics for remyelination. As a proof of concept, this platform employed scaffold-mediated non-viral delivery of a microRNA (miR) cocktail to promote oligodendrocyte precursor cells (OPCs) differentiation and myelination...
June 6, 2018: Acta Biomaterialia
Ping Wang, Larry J Kricka
BACKGROUND: Point-of-care technology (POCT)2 provides actionable information at the site of care to allow rapid clinical decision-making. With healthcare emphasis shifting toward precision medicine, population health, and chronic disease management, the potential impact of POCT continues to grow, and several prominent POCT trends have emerged or strengthened in the last decade. CONTENT: This review summarizes current and emerging trends in POCT, including technologies approved or cleared by the Food and Drug Administration or in development...
June 8, 2018: Clinical Chemistry
N V Srikanth Vallabani, Sanjay Singh
Superparamagnetic iron oxide nanoparticles (SPIONs) are considered as chemically inert materials and, therefore, being extensively applied in the areas of imaging, targeting, drug delivery and biosensors. Their unique properties such as low toxicity, biocompatibility, potent magnetic and catalytic behavior and superior role in multifunctional modalities have epitomized them as an appropriate candidate for biomedical applications. Recent developments in the area of materials science have enabled the facile synthesis of Iron oxide nanoparticles (IONPs) offering easy tuning of surface properties and surface functionalization with desired biomolecules...
June 2018: 3 Biotech
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