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Drug delivery devices

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https://www.readbyqxmd.com/read/28633977/vascular-endothelial-cell-mechanosensing-new-insights-gained-from-biomimetic-microfluidic-models
#1
REVIEW
Kelsey M Gray, Kimberly M Stroka
In vivo, cells of the vascular system are subjected to various mechanical stimuli and have demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances in microfluidic and "on-chip" techniques have provided the technology to study these alterations in cell behavior. Contrary to traditional in vitro assays such as transwell plates and parallel plate flow chambers, these microfluidic devices (MFDs) provide the opportunity to integrate multiple mechanical cues (e.g. shear stress, confinement, substrate stiffness, vessel geometry and topography) with in situ quantification capabilities...
June 17, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#2
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28630677/non-lamellar-lipid-assembly-at-interfaces-controlling-layer-structure-by-responsive-nanogel-particles
#3
Aleksandra P Dabkowska, Maria Valldeperas, Christopher Hirst, Costanza Montis, Gunnar K Pálsson, Meina Wang, Sofi Nöjd, Luigi Gentile, Justas Barauskas, Nina-Juliane Steinke, Gerd E Schroeder-Turk, Sebastian George, Maximilian W A Skoda, Tommy Nylander
Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing three-dimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid non-lamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28628999/synthesis-characterisation-and-phase-transition-behaviour-of-temperature-responsive-physically-crosslinked-poly-n-vinylcaprolactam-based-polymers-for-biomedical-applications
#4
Shane C Halligan, Maurice B Dalton, Kieran A Murray, Yixiao Dong, Wenxin Wang, John G Lyons, Luke M Geever
Poly (N-vinylcaprolactam) (PNVCL) is a polymer which offers superior characteristics for various potential medical device applications. In particular it offers unique thermoresponsive capabilities, which fulfils the material technology constraints required in targeted drug delivery applications. PNVCL phase transitions can be tailored in order to suit the requirements of current and next generation devices, by modifying the contents with regard to the material composition and aqueous polymer concentration. In this study, physically crosslinked Poly (N-vinylcaprolactam)-Vinyl acetate (PNVCL-VAc) copolymers were prepared by photopolymerisation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628167/a-theoretical-study-on-the-morphological-phase-diagram-of-supported-lipid-bilayers
#5
Xian Kong, Diannan Lu, Jianzhong Wu, Zheng Liu
Supported lipid bilayers (SLBs) have been widely used in drug delivery, biosensors and biomimetic membranes. The microscopic mechanism of SLB formation and stability depends on a number of factors underlying solvent-mediated lipid-lipid and lipid-substrate interactions. Whereas recent years have witnessed remarkable progress in understanding the kinetics of SLB formation, relatively little is known about the lipid phase behavior controlling the SLB stability under diverse solution conditions. In this work, we examine the structure of SLBs using classical density functional theory (CDFT) in the context of a coarse-grained model that accounts for ion-explicit electrostatic interactions, surface hydrophobicity, as well as the molecular characteristics of the lipid tails...
June 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#6
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28625062/bioinspired-hand-operating-smart-wetting-systems-using-smooth-liquid-coatings
#7
Mizuki Tenjimbayashi, Takeshi Matsubayashi, Takeo Moriya, Seimei Shiratori
Manually controllable 'hand-operating' smart systems have been developed in many fields, including smart wetting materials, electronic devices, molecular machines, and drug delivery systems. Because complex morphological or chemical control are generally required, versatile strategies for constructing the system are technologically important. Inspired by the natural phenomenon of raindrops rarely bouncing and usually spreading on a puddle, we introduce a droplet-impact-triggering smart-wetting system using "non-smart" smooth liquid coating materials...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28624192/stimuli-responsive-mesoporous-silica-nps-as-non-viral-dual-sirna-chemotherapy-carriers-for-triple-negative-breast-cancer
#8
REVIEW
Behrad Darvishi, Leila Farahmand, Keivan Majidzadeh-A
Triple negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer. It is associated with a very poor prognosis and intrinsically resistant to several conventional and targeted chemotherapy agents and has a 5-year survival rate of less than 25%. Because the treatment options for TNBC are very limited and not efficient enough for achieving minimum desired goals, shifting toward a new generation of anti-cancer agents appears to be very critical. Among recent alternative approaches being proposed, small interfering RNA (siRNA) gene therapy can potently suppress Bcl-2 proto-oncogene and p-glycoprotein gene expression, the most important chemotherapy resistance inducers in TNBC...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28617335/zno-nano-rod-devices-for-intradermal-delivery-and-immunization
#9
Tapas R Nayak, Hao Wang, Aakansha Pant, Minrui Zheng, Hans Junginger, Wei Jiang Goh, Choon Keong Lee, Shui Zou, Sylvie Alonso, Bertrand Czarny, Gert Storm, Chorng Haur Sow, Chengkuo Lee, Giorgia Pastorin
Intradermal delivery of antigens for vaccination is a very attractive approach since the skin provides a rich network of antigen presenting cells, which aid in stimulating an immune response. Numerous intradermal techniques have been developed to enhance penetration across the skin. However, these methods are invasive and/or affect the skin integrity. Hence, our group has devised zinc oxide (ZnO) nano-rods for non-destructive drug delivery. Chemical vapour deposition was used to fabricate aligned nano-rods on ZnO pre-coated silicon chips...
June 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28602009/update-on-intranasal-medications-in-rhinosinusitis
#10
REVIEW
Kornkiat Snidvongs, Sanguansak Thanaviratananich
This review describes beneficial effects and adverse events of various intranasal medications in treating rhinosinusitis. Application of intranasal steroids has been described in treating all subtypes of adult rhinosinusitis, but reports are limited in pediatrics and mostly in acute pediatric subgroups resulted in benefits While saline irrigation is effective for patients with chronic rhinosinusitis without polyps and in pediatric acute rhinosinusitis, there is no evidence yet for saline drips and sprays. Application of intranasal antifungals and nasal irrigation with surfactant brings more harm than benefits...
July 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28589558/potential-applications-and-human-biosafety-of-nanomaterials-used-in-nanomedicine
#11
REVIEW
Hong Su, Yafei Wang, Yuanliang Gu, Linda Bowman, Jinshun Zhao, Min Ding
With the rapid development of nanotechnology, potential applications of nanomaterials in medicine have been widely researched in recent years. Nanomaterials themselves can be used as image agents or therapeutic drugs, and for drug and gene delivery, biological devices, nanoelectronic biosensors or molecular nanotechnology. As the composition, morphology, chemical properties, implant sites as well as potential applications become more and more complex, human biosafety of nanomaterials for clinical use has become a major concern...
June 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28589118/innovative-programmable-bio-nano-chip-digitizes-biology-using-sensors-that-learn-bridging-biomarker-discovery-and-clinical-implementation
#12
REVIEW
Nicolaos J Christodoulides, Michael P McRae, Timothy J Abram, Glennon W Simmons, John T McDevitt
The lack of standard tools and methodologies and the absence of a streamlined multimarker approval process have hindered the translation rate of new biomarkers into clinical practice for a variety of diseases afflicting humankind. Advanced novel technologies with superior analytical performance and reduced reagent costs, like the programmable bio-nano-chip system featured in this article, have potential to change the delivery of healthcare. This universal platform system has the capacity to digitize biology, resulting in a sensor modality with a capacity to learn...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28585877/future-of-automated-insulin-delivery-systems
#13
Jessica R Castle, J Hans DeVries, Boris Kovatchev
Advances in continuous glucose monitoring (CGM) have brought on a paradigm shift in the management of type 1 diabetes. These advances have enabled the automation of insulin delivery, where an algorithm determines the insulin delivery rate in response to the CGM values. There are multiple automated insulin delivery (AID) systems in development. A system that automates basal insulin delivery has already received Food and Drug Administration approval, and more systems are likely to follow. As the field of AID matures, future systems may incorporate additional hormones and/or multiple inputs, such as activity level...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28583328/3d-printed-tablets-loaded-with-polymeric-nanocapsules-an-innovative-approach-to-produce-customized-drug-delivery-systems
#14
R C R Beck, P S Chaves, A Goyanes, B Vukosavljevic, A Buanz, M Windbergs, A W Basit, S Gaisford
The generation of multi-functional drug delivery systems, namely solid dosage forms loaded with nano-sized carriers, remains little explored and is still a challenge for formulators. For the first time, the coupling of two important technologies, 3D printing and nanotechnology, to produce innovative solid dosage forms containing drug-loaded nanocapsules was evaluated here. Drug delivery devices were prepared by fused deposition modelling (FDM) from poly(ε-caprolactone) (PCL) and Eudragit(®) RL100 (ERL) filaments with or without a channelling agent (mannitol)...
June 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28582029/endovascular-drug-delivery-and-drug-elution-systems-first-principles
#15
REVIEW
Abraham Rami Tzafriri, Elazer Reuven Edelman
Endovascular drug delivery continues to revolutionize the treatment of atherosclerosis in coronary and peripheral vasculature. The key has been to identify biologic agents that can counter the hyperplastic tissue responses to device expansion/implantation and to develop effective local delivery strategies that can maintain efficacious drug levels across the artery wall over the course of device effects. This article reviews the evolution of endovascular drug delivery technology, explains the mechanisms they use for drug release, and provides a quantitative mechanistic framework for relating drug release mode to arterial drug distribution and effect...
July 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28580592/shape-controlled-hollow-mesoporous-silica-nanoparticles-with-multifunctional-capping-for-in-vitro-cancer-treatment
#16
Hongya Geng, Weiyu Chen, Ping Zhi Xu, Guangren Qian, Jing An, Haijiao Zhang
In the work, we prepare a series of multifunctional shape-controlled non-spherical hollow mesoporous silica nanoparticles (HMSNs) drug carriers by employing Fe2O3 with four morphologies (capsule, cube, rice and rhombus) as sacrificial template and multifunctional cap as the encapsulating shell, respectively. The resulting shape-controlled non-spherical HMSNs perfectly replicate the origin morphology of Fe2O3 templates, possessing high specific surface area, good monodispersity, perpendicular mesoporous channel and excellent biocompatibility...
June 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28579697/hydrodynamically-driven-drug-release-during-interstitial-flow-through-hollow-fibers-implanted-near-lymphatics
#17
Stanislav S Dukhin, Mohamed E Labib
Current drug delivery devices (DDD) are mainly based on the use of diffusion as the main transport process. Diffusion-driven processes can only achieve low release rate because diffusion is a slow process. This represents a serious obstacle in the realization of recent successes in the suppression of lymphatic metastasis and in the prevention of limb and organ transplant rejection. Surprisingly, it was overlooked that there is a more favorable drug release mode which can be achieved when a special DDD is implanted near lymphatics...
May 20, 2017: Colloids and Surfaces. A, Physicochemical and Engineering Aspects
https://www.readbyqxmd.com/read/28576549/computational-and-experimental-model-of-transdermal-iontophorethic-drug-delivery-system
#18
Nenad Filipovic, Igor Saveljic, Vladislav Rac, Beatriz Olalde Graells, Goran Bijelic
The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin...
May 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28571834/self-powered-therapeutic-release-from-conducting-polymer-graphene-oxide-films-on-magnesium
#19
Kasey Catt, Huaxiu Li, Victor Hoang, Roland Beard, X Tracy Cui
Magnesium's complete in vivo degradation is appealing for medical implant applications. Rapid corrosion and hydrogen bubble generation along with inflammatory host tissue response have limited its clinical use. Here we electropolymerized a poly(3,4-ethylenedioxythiophene) (PEDOT) and graphene Oxide (GO) film directly on Mg surface. GO acted as nano-drug carrier to carry anti-inflammatory drug dexamethasone (Dex). PEDOT/GO/Dex coatings improved Mg corrosion resistance and decreased the rate of hydrogen production...
May 29, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28566498/thermal-combination-therapies-for-local-drug-delivery-by-magnetic-resonance-guided-high-intensity-focused-ultrasound
#20
Nicole Hijnen, Esther Kneepkens, Mariska de Smet, Sander Langereis, Edwin Heijman, Holger Grüll
Several thermal-therapy strategies such as thermal ablation, hyperthermia-triggered drug delivery from temperature-sensitive liposomes (TSLs), and combinations of the above were investigated in a rhabdomyosarcoma rat tumor model (n = 113). Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) was used as a noninvasive heating device with precise temperature control for image-guided drug delivery. For the latter, TSLs were prepared, coencapsulating doxorubicin (dox) and [Gd(HPDO3A)(H2O)], and injected in tumor-bearing rats before MR-HIFU treatment...
May 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
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