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https://www.readbyqxmd.com/read/29774296/integrated-risk-mapping-and-landscape-characterisation-of-lymphatic-filariasis-and-loiasis-in-south-west-nigeria
#1
Tara A Brant, Patricia N Okorie, Olushola Ogunmola, Nureni Bolaji Ojeyode, S B Fatunade, Emmanuel Davies, Yisa Saka, Michelle C Stanton, David H Molyneux, J Russell Stothard, Louise A Kelly-Hope
Nigeria has the heaviest burden of lymphatic filariasis (LF) in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA) across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis) is an impediment due to the risk of severe adverse events (SAEs) associated with the drug ivermectin...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774284/rapid-integrated-clinical-survey-to-determine-prevalence-and-co-distribution-patterns-of-lymphatic-filariasis-and-onchocerciasis-in-a-loa-loa-co-endemic-area-the-angolan-experience
#2
Miguel Brito, Rossely Paulo, Pedro Van-Dunem, António Martins, Thomas R Unnasch, Robert J Novak, Benjamin Jacob, Michelle C Stanton, David H Molyneux, Louise A Kelly-Hope
The Republic of Angola is a priority country for onchocerciasis and lymphatic filariasis (LF) elimination, however, the co-distribution of the filarial parasite Loa loa (loiasis) is a significant impediment, due to the risk of severe adverse events (SAEs) associated with ivermectin used in mass drug administration (MDA) campaigns. Angola has a high risk loiasis zone identified in Bengo Province where alternative interventions may need to be implemented; however, the presence and geographical overlap of the three filarial infections/diseases are not well defined...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29773516/lymphoedema-management-to-prevent-acute-dermatolymphangioadenitis-in-podoconiosis-in-northern-ethiopia-golbet-a-pragmatic-randomised-controlled-trial
#3
Henok Negussie, Meseret Molla, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
BACKGROUND: Podoconiosis (also known as endemic, non-filarial elephantiasis) affects about 4 million subsistence farmers in tropical Africa. Poor awareness of the condition and inadequate evidence for the efficacy of treatment mean that no government in an endemic country yet offers lymphoedema management for patients with podoconiosis. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: episodes of acute dermatolymphangioadenitis...
May 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29771349/study-of-lymphoedema-of-non-filarial-origin-in-the-northwest-region-of-cameroon-spatial-distribution-profiling-of-cases-and-socio-economic-aspects-of-podoconiosis
#4
Samuel Wanji, Jonas A Kengne-Ouafo, Kebede Deribe, Ayok M Tembei, Abdel Jelil Njouendou, Dizzel Bita Tayong, David D Sofeu-Feugaing, Fabrice R Datchoua-Poutcheu, Jorge Cano, Emanuele Giorgi, Yolande F Longang-Tchounkeu, Peter A Enyong, Melanie J Newport, Gail Davey
Background: Although podoconiosis is endemic in Cameroon, little is known about its epidemiology and spatial distribution. Methods: This cross-sectional, population-based study enrolled all adults (≥15 y) residing in the districts of the northwest region of Cameroon for 10 or more years. Participants were interviewed and had a physical examination. The study outcomes were prevalence estimates of lymphoedema and podoconiosis. House-to-house screening was conducted by Community Health Implementers (CHIs)...
May 16, 2018: International Health
https://www.readbyqxmd.com/read/29761764/case-report-filaria-or-megasperm-a-cause-of-an-ultrasonographic-filarial-dance-sign
#5
J Brad Wiggers, Hyun-Jung Jang, Jay S Keystone
Bancroftian filariasis can cause genital abnormalities related to chronic inflammation and obstruction of the afferent lymphatic vessels, and may demonstrate a "filarial dance sign" on scrotal ultrasound with mobile echogenic particles observed. We present a patient with a positive "filarial dance sign," travel within Latin America and negative filarial serology.
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29746479/morbidity-management-and-disability-prevention-for-lymphatic-filariasis-in-sri-lanka-current-status-and-future-prospects
#6
Nilmini Chandrasena, Ranjan Premaratna, Indeewarie E Gunaratna, Nilanthi R de Silva
BACKGROUND: Sri Lanka was acknowledged to have eliminated lymphatic filariasis (LF) as a public health problem in 2016, largely due to its success in Mass Drug Administration (MDA) to interrupt disease transmission. Analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT) of the national Morbidity Management and Disability Prevention (MMDP) program, the other pillar of the LF control program, was carried out with the objective of evaluating it and providing recommendations to optimize the use of available resources...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29741149/case-report-probable-case-of-spontaneous-encephalopathy-due-to-loiasis-and-dramatic-reduction-of-loa-loa-microfilariaemia-with-prolonged-repeated-courses-of-albendazole
#7
Divine B Arrey-Agbor, Hugues C Nana-Djeunga, Aude E Mogoung-Wafo, Mirabelle Mafo, Christian Danwe, Joseph Kamgno
Loiasis is a vector-borne parasitic disease caused by the filarial nematode Loa loa and transmitted by the tabanid vectors from the genus Chrysops . Loa loa infection is associated with clinical manifestations such as pruritus, migratory transient edema, passage of adult worm in the bulbar conjunctiva, retinal damage, glomerular damage, albuminuria, pleural effusion, hydrocele, and endomyocardial fibrosis. Data reporting the occurrence of spontaneous encephalopathy associated with loiasis are very scanty. Severe adverse events occurring post-ivermectin administered in the framework of the fight against onchocerciasis and/or lymphatic filariasis in loiasis co-endemic areas have been closely associated with very high L...
May 7, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29723238/interruption-of-onchocerciasis-transmission-in-bioko-island-accelerating-the-movement-from-control-to-elimination-in-equatorial-guinea
#8
Zaida Herrador, Belén Garcia, Policarpo Ncogo, Maria Jesus Perteguer, Jose Miguel Rubio, Eva Rivas, Marta Cimas, Guillermo Ordoñez, Silvia de Pablos, Ana Hernández-González, Rufino Nguema, Laura Moya, María Romay-Barja, Teresa Garate, Kira Barbre, Agustín Benito
BACKGROUND: Onchocerciasis, also known as river blindness, is a parasitic disease. More than 99 percent of all cases occur in Africa. Bioko Island (Equatorial Guinea) is the only island endemic for onchocerciasis in the world. Since 2005, when vector Simulium yahense was eliminated, there have not been any reported cases of infection. This study aimed to demonstrate that updated WHO criteria for stopping mass drug administration (MDA) have been met. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study was conducted from September 2016 to January 2017...
May 3, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29720887/rapid-progress-towards-elimination-of-lymphatic-filariasis-in-endemic-regions-of-myanmar-as-a-result-of-16-years-of-anti-filarial-activities-2001-2016
#9
Kyawt Mon Win, Jaya Prasad Tripathy, Thae Maung Maung, Tin Oo, Aung Thi, Khin Nan Lon, Zaw Lin
Background: As Myanmar progresses towards lymphatic filariasis (LF) elimination, it is important to know how well the anti-filarial activities have performed. The present study was conducted to study the implementation of the key anti-filarial activities and their impact on key indicators of LF transmission. Methods: A secondary analysis of aggregate program data on the anti-filarial activities was conducted in four endemic state/regions of Myanmar receiving at least six mass drug administration (MDA) rounds during 2001-2016...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29720217/chiluria-in-a-lymphatic-filariasis-endemic-area
#10
Paulo Sérgio Ramos de Araújo, Valter Romão de Souza Junior, Anderson de Souza, Luciana de Barros Correia Fontes, Eduardo Brandao, Abraham Rocha
OBJECTIVE: To establish clinical and laboratory data of individuals presenting chyluria in endemic areas. RESULTS: 75 individuals were studied. The majority were females with an average age of 45 years residing in the Metropolitan Region of Recife. The mean time between the beginning of the presentation of chyluria and the first care service in the Serviço de Referencia Nacional em Filarioses was approximately 5 years. The most frequent urinalysis changes were hematuria (27...
May 2, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29716541/onchocerca-infected-cattle-produce-strong-antibody-responses-to-excretory-secretory-proteins-released-from-adult-male-onchocerca-ochengi-worms
#11
Djafsia Boursou, Dieudonné Ndjonka, Albert Eisenbarth, Kingsley Manchang, Archille Paguem, Nancy Ngwafu Ngwasiri, Jacqueline Dikti Vildina, Babette Abanda, Ralf Krumkamp, Silke van Hoorn, Alfons Renz, Mbunkah Daniel Achukwi, Eva Liebau, Norbert W Brattig
BACKGROUND: The front line molecules from filarial worms and other nematodes or helminthes are their Excretory-Secretory (ES) products. Their interaction with the host cells, proteins and immune system accounts for the skin and eye pathology or hyposensitivity observed in human onchocerciasis. ES products and adult worms' crude extracts from Onchocerca ochengi, a filarial nematode that infects the African zebu cattle, were utilized in the present study as a model for studying Onchocerca volvulus that causes river blindness in man...
May 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29709778/electrochemical-immunosensor-for-differential-diagnostic-of-wuchereria-bancrofti-using-a-synthetic-peptide
#12
Isis C Prado, Verônica G Mendes, André L A Souza, Rosa F Dutra, Salvatore G De-Simone
Lymphatic filariasis (LF) is a neglected tropical disease transmitted by mosquitoes and the second cause of permanent disability leading to a significant morbidity and mortality rate. Previously, we have identified epitopes of the filarial abundant larval transcript-2 (ALT-2) protein using a microarray mapping. In this study, one of the epitopes (Wb/ALT2-A5) was used to construct an electrochemical immunosensor. Electrochemical technique of cyclic voltammetry was performed for detecting the signal generated by the interaction between the (Wb/ALT2-A5) peptide and circulating antibodies of serum human samples...
April 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29690912/urbanization-impact-on-mosquito-community-and-the-transmission-potential-of-filarial-infection-in-central-europe
#13
Viktória Čabanová, Martina Miterpáková, Daniela Valentová, Hana Blažejová, Ivo Rudolf, Eduard Stloukal, Zuzana Hurníková, Marianna Dzidová
BACKGROUND: Despite long-term research on dirofilariosis in Slovakia, little attention has thus far been paid to Dirofilaria vectors. The particular aim of the present study was molecular screening for filarioid parasites in two different habitats of Bratislava, the capital city of Slovakia. In addition, the effect of urbanisation on mosquito species abundance and composition, associated with the risk of mosquito-borne infections, was studied and discussed. METHODS: Mosquitoes were identified by morphological features, and molecular methods were also used for determination of selected individuals belonging to cryptic species from the Anopheles maculipennis and Culex pipiens complexes...
April 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29689195/wolbachia-control-stem-cell-behavior-and-stimulate-germline-proliferation-in-filarial-nematodes
#14
Vincent Foray, Mercedes M Pérez-Jiménez, Nour Fattouh, Frédéric Landmann
Although symbiotic interactions are ubiquitous in the living world, examples of developmental symbioses are still scarce. We show here the crucial role of Wolbachia in the oogenesis of filarial nematodes, a class of parasites of biomedical and veterinary relevance. We applied newly developed techniques to demonstrate the earliest requirements of Wolbachia in the parasite germline preceding the production of faulty embryos in Wolbachia-depleted nematodes. We show that Wolbachia stimulate germline proliferation in a cell-autonomous manner, and not through nucleotide supplementation as previously hypothesized...
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29670192/mansonella-ozzardi-mitogenome-and-pseudogene-characterisation-provides-new-perspectives-on-filarial-parasite-systematics-and-co-1-barcoding
#15
James Lee Crainey, Michel Abanto Marín, Túllio Romão Ribeiro da Silva, Jansen Fernandes de Medeiros, Felipe Arley Costa Pessoa, Yago Vinícius Santos, Ana Carolina Paulo Vicente, Sérgio Luiz Bessa Luz
Despite the broad distribution of M. ozzardi in Latin America and the Caribbean, there is still very little DNA sequence data available to study this neglected parasite's epidemiology. Mitochondrial DNA (mtDNA) sequences, especially the cytochrome oxidase (CO1) gene's barcoding region, have been targeted successfully for filarial diagnostics and for epidemiological, ecological and evolutionary studies. MtDNA-based studies can, however, be compromised by unrecognised mitochondrial pseudogenes, such as Numts...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29659599/profiling-extracellular-vesicle-release-by-the-filarial-nematode-brugia-malayi-reveals-sex-specific-differences-in-cargo-and-a-sensitivity-to-ivermectin
#16
Hiruni Harischandra, Wang Yuan, Hannah J Loghry, Mostafa Zamanian, Michael J Kimber
The filarial nematode Brugia malayi is an etiological agent of Lymphatic Filariasis. The capability of B. malayi and other parasitic nematodes to modulate host biology is recognized but the mechanisms by which such manipulation occurs are obscure. An emerging paradigm is the release of parasite-derived extracellular vesicles (EV) containing bioactive proteins and small RNA species that allow secretion of parasite effector molecules and their potential trafficking to host tissues. We have previously described EV release from the infectious L3 stage B...
April 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29651095/validation-of-ultrasound-bioimaging-to-predict-worm-burden-and-treatment-efficacy-in-preclinical-filariasis-drug-screening-models
#17
Amy E Marriott, Hanna Sjoberg, Hayley Tyrer, Joanne Gamble, Emma Murphy, John Archer, Andrew Steven, Mark J Taylor, Joseph D Turner
Filariasis is a global health problem targeted for elimination. Curative drugs (macrofilaricides) are required to accelerate elimination. Candidate macrofilaricides require testing in preclinical models of filariasis. The incidence of infection failures and high intra-group variation means that large group sizes are required for drug testing. Further, a lack of accurate, quantitative adult biomarkers results in protracted timeframes or multiple groups for endpoint analyses. Here we evaluate intra-vital ultrasonography (USG) to identify B...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649225/insulin-receptor-knockdown-blocks-filarial-parasite-development-and-alters-egg-production-in-the-southern-house-mosquito-culex-quinquefasciatus
#18
Andrew Bradley Nuss, Mark R Brown, Upadhyayula Suryanarayana Murty, Monika Gulia-Nuss
Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. Wuchreria bancrofti (Wb) is responsible for >90% of infections and the remainder are caused by Brugia spp. Mosquitoes of the genera Culex (in urban and semi-urban areas), Anopheles (in rural areas of Africa and elsewhere), and Aedes (in Pacific islands) are the major vectors of W. bancrofti. A preventive chemotherapy called mass drug administration (MDA), including albendazole with ivermectin or diethylcarbamazine citrate (DEC) is used in endemic areas...
April 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29630086/isolated-epitrochlear-filarial-lymphadenopathy-cytomorphological-diagnosis-of-an-unusual-presentation
#19
Priya Sahu, Prajwala Gupta, Minakshi Bhardwaj, C K Durga
Filariasis is a major public health problem in tropical countries like India. Despite the large number of people at risk, detection of eggs with or without larva (microfilaria) on fine-needle aspiration cytology is very unusual, especially in an uncommon site or incidentally detected in clinically unsuspected cases of filariasis with the absence of microfilariae in the peripheral blood. A 19-year-old male presented with swelling over medial aspect of left arm (just above the elbow), with no other specific signs and symptoms...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29625152/g-protein-coupled-receptor-genes-of-dirofilaria-immitis
#20
Thangadurai Mani, Catherine Bourguinat, Roger K Prichard
The diversity and uniqueness of nematode heterotrimeric G-protein-coupled receptors (GPCRs) provides impetus for identifying ligands that can be used as therapeutics for treating diseases caused by parasitic nematode infections. In human medicine, GPCRs have represented the largest group of 'drugable' targets exploited in the market today. In the filarial nematode Dirofilaria immitis, which causes heartworm disease, the macrocyclic lactones (ML) have been used as the sole preventatives for more than 25 years and now there is confirmed ML resistance in this parasite...
April 3, 2018: Molecular and Biochemical Parasitology
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