keyword
https://read.qxmd.com/read/38461686/pharmacokinetic-considerations-for-enhancing-drug-repurposing-opportunities-of-anthelmintics-niclosamide-as-a-case-study
#21
JOURNAL ARTICLE
Jeong In Seo, Geun-Woo Jin, Hye Hyun Yoo
Recently, anthelmintics have showcased versatile therapeutic potential in addressing various diseases, positioning them as promising candidates for drug repurposing. However, challenges such as low bioavailability and a lack of a solid pharmacokinetic basis impede successful repurposing. To overcome these flaws, we aimed to investigate the key pharmacokinetic factors of anthelmintics mainly focusing on the absorption, distribution, and metabolism profiles by employing niclosamide (NIC) as a model drug. The intestinal permeability of NIC is significantly influenced by solubility and doesn't function as a substrate for efflux transporters...
March 9, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38457966/duration-of-fermentation-affects-microbiome-composition-and-biological-activity-of-an-indian-traditional-formulation-panchagavya
#22
JOURNAL ARTICLE
Gemini Gajera, Snehal Funde, Hanmanthrao Palep, Vijay Kothari
OBJECTIVE: This study aimed at investigating whether the duration of fermenting Panchagavya (PG) preparation in copper vessel affects its biological activity and microbiome composition. MATERIALS AND METHODS: Prophylactic potential of PG against bacterial infection was assessed through an in vivo assay employing the nematode worm Caenorhabditis elegans as a model host. Bacterial diversity of the PG samples was revealed through metagenomic analysis. RESULTS: Duration of fermentation was found to affect biological activity as well as microbiome composition of the PG samples...
March 7, 2024: Journal of Ayurveda and Integrative Medicine
https://read.qxmd.com/read/38454593/evaluation-of-anthelmintic-activity-of-medicinal-plants-why-earthworm
#23
JOURNAL ARTICLE
Sanjib Bhattacharya
No abstract text is available yet for this article.
January 1, 2024: Indian Journal of Pharmacology
https://read.qxmd.com/read/38453425/less-is-more-anthelmintic-stewardship-in-an-era-of-ubiquitous-anthelmintic-resistance-and-environmental-sustainability
#24
EDITORIAL
David Rendle, Mark Bowen, Jane Hodgkinson
No abstract text is available yet for this article.
March 7, 2024: Equine Veterinary Journal
https://read.qxmd.com/read/38452642/a-primary-pleural-hydatid-cyst-was-discovered-months-after-an-undiagnosed-pneumothorax-a-diagnostic-and-therapeutic-dilemma-in-a-rare-case-report-from-syria
#25
Hamdah Hanifa, Turki Al-Shaher, Mamoun Jaber, Jaafar Alatm, Khayry Al-Shami, Salem Algomaa Alhadid
INTRODUCTION: Primary pleural hydatid cysts (PPHCs) are a rare clinical condition caused by the larval stage of the parasite Echinococcus granulosus. They occur in <1 % of all hydatid cysts in the body and can cause serious complications such as pneumothorax, pleural effusion, and mediastinal shift. PRESENTATION OF CASE: We report a rare case of a 28-year-old female who was initially misdiagnosed and ignored her pneumothorax for several months, resulting in progressive dyspnea and chest pain...
March 5, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38449298/neurocysticercosis-presenting-as-migraine-in-the-united-states
#26
JOURNAL ARTICLE
Eamonn Byrnes, Brian Shaw, Ryan Shaw, Mario Madruga, Stephen J Carlan
BACKGROUND Cysticercosis is a condition caused by infection with the larval form of Taenia solium, a pork tapeworm that uses pigs as an intermediate host. Humans become infected when they ingest water or food contaminated with tapeworm cysts. Cysticercosis is increasing in frequency in developed countries due to increased access to travel. Neurocysticercosis occurs when Taenia solium cysts embed within the nervous system. The clinical presentation of neurocysticercosis ranges from asymptomatic to life-threatening, largely depending on the brain parenchymal involvement...
March 7, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38448148/getting-around-the-roundworms-identifying-knowledge-gaps-and-research-priorities-for-the-ascarids
#27
JOURNAL ARTICLE
Adrian J Wolstenholme, Erik C Andersen, Shivani Choudhary, Friederike Ebner, Susanne Hartmann, Lindy Holden-Dye, Sudhanva S Kashyap, Jürgen Krücken, Richard J Martin, Ankur Midha, Peter Nejsum, Cedric Neveu, Alan P Robertson, Georg von Samson-Himmelstjerna, Robert Walker, Jianbin Wang, Bradley J Whitehead, Paul D E Williams
The ascarids are a large group of parasitic nematodes that infect a wide range of animal species. In humans, they cause neglected diseases of poverty; many animal parasites also cause zoonotic infections in people. Control measures include hygiene and anthelmintic treatments, but they are not always appropriate or effective and this creates a continuing need to search for better ways to reduce the human, welfare and economic costs of these infections. To this end, Le Studium Institute of Advanced Studies organized a two-day conference to identify major gaps in our understanding of ascarid parasites with a view to setting research priorities that would allow for improved control...
2024: Advances in Parasitology
https://read.qxmd.com/read/38447333/revisiting-anthelmintic-resistance-in-sheep-flocks-from-s%C3%A3-o-paulo-state-brazil
#28
JOURNAL ARTICLE
Cesar C Bassetto, Ana Cláudia A Albuquerque, José Gabriel G Lins, Naiara M Marinho-Silva, Marianna L E Chocobar, Hornblenda J S Bello, Mateus O Mena, Simone C M Niciura, Alessandro F T Amarante, Ana Carolina S Chagas
Haemonchus contortus and Trichostrongylus colubriformis are the most important gastrointestinal nematodes causing serious losses in sheep production of tropical and subtropical regions. Prophylaxis of gastrointestinal nematode infections is based on anthelmintics use, but their frequent administration selects multiple-resistant parasites. To evaluate how the situation has changed over the last decades, the anthelmintic resistance status of gastrointestinal nematodes in sheep flocks was assessed in the current study and compared to previous surveys...
February 28, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38440768/anthelmintic-efficacy-of-phlogacanthus-thyrsiflorus-leaf-extract-on-juvenile-and-adult-worms-of-hymenolepis-diminuta-cestoda
#29
JOURNAL ARTICLE
Khirod Deori, Arun K Yadav, Amar Deep Soren
The leaves of Phlogacanthus thyrsiflorus are used as an anthelmintic remedy by the tribal communities of upper Assam in India. The present study was carried out to validate the anthelmintic credentials of this plant. Mature and larval Hymenolepis diminuta worms were exposed to varying concentration of methanolic leaf extract of plant and parasites were observed for paralysis and mortality. At the end of the experiment, worms were collected and processed for scanning electron microscopy (SEM) study to observe the effect of extract on tegument of parasite...
March 2024: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://read.qxmd.com/read/38440765/correction-anthelmintic-and-therapeutic-effects-of-the-biogenic-zinc-oxide-nanoparticles-against-acute-kidney-injury-induced-by-parascaris-equorum-infection-in-rats
#30
Sara Bayoumi Ali, Ayman Saber Mohamed, Sohair R Fahmy, Manal El-Garhy, Mohamed R Mousa, Fathy Abdel-Ghaffar
[This corrects the article DOI: 10.1007/s12639-023-01637-z.].
March 2024: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://read.qxmd.com/read/38440752/ovicidal-larvicidal-and-adulticidal-activity-of-black-pepper-piper-nigrum-%C3%A2-l-essential-oil-and-tea-tree-oil-melaleuca-alternifolia-against-haemonchus-contortus
#31
JOURNAL ARTICLE
Hend Ibrahim Mohamed, Waleed M Arafa, Osama M Ahmed, Khaled Mohamed El-Dakhly
Haemonchosis is a worldwide helminthic disease affecting ruminants. The anthelminthic resistance has become raised. Medicinal plants are safely used as synthetic anthelmintics. Currently, the efficacy of black pepper essential oil (BPO) and tea tree oil (TTO) were in vitro evaluated against Haemonchus contortus adults, eggs and larvae at concentrations of 1.25, 2.5 and 5 mg/ml in addition to the commercially used albendazole at a concentration of 10 μg/ml. Oils were used in both normal and nanoparticles-loaded forms...
March 2024: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://read.qxmd.com/read/38440749/anthelmintic-and-therapeutic-effects-of-the-biogenic-zinc-oxide-nanoparticles-against-acute-kidney-injury-induced-by-parascaris-equorum-infection-in-rats
#32
JOURNAL ARTICLE
Sara Bayoumi Ali, Ayman Saber Mohamed, Sohair R Fahmy, Manal El-Garhy, Mohamed R Mousa, Fathy Abdel-Ghaffar
Complications of parasite infections, especially kidney disease, have been linked to poorer outcomes. Acute kidney damage, glomerulonephritis, and tubular dysfunction are the most prevalent renal consequences of Parascaris equorum infection. The purpose of this study was to determine the pharmacological effects of green-produced zinc oxide nanoparticles (ZnO NPs) on P. equorum infection in male Wistar rats. Thirty-six male rats were divided into two groups of 18 each: infected and non-infected. Both groups were separated into three subgroups, each of which received distilled water, 30 mg/kg ZnO NPs, and 60 mg/kg ZnO NPs...
March 2024: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://read.qxmd.com/read/38439699/crispr-aided-genome-engineering-for-secondary-metabolite-biosynthesis-in-streptomyces
#33
JOURNAL ARTICLE
Yongjae Lee, Soonkyu Hwang, Woori Kim, Ji Hun Kim, Bernhard O Palsson, Byung-Kwan Cho
The demand for discovering novel microbial secondary metabolites is growing to address the limitations in bioactivities such as antibacterial, antifungal, anticancer, anthelmintic, and immunosuppressive functions. Among microbes, the genus Streptomyces holds particular significance for secondary metabolite discovery. Each Streptomyces species typically encodes approximately 30 secondary metabolite biosynthetic gene clusters within its genome, which are mostly uncharacterized in terms of their products and bioactivities...
March 4, 2024: Journal of Industrial Microbiology & Biotechnology
https://read.qxmd.com/read/38436800/role-of-silver-nanoparticles-for-the-control-of-anthelmintic-resistance-in-small-and-large-ruminants
#34
REVIEW
Sahar Mustafa, Lafi M Alharbi, Mona Z Abdelraheem, Muhammad Mobashar, Warda Qamar, Amin A Al-Doaiss, Rao Zahid Abbas
Helminths are considered a significant threat to the livestock industry, as they cause substantial economic losses in small and large ruminant farming. Their morbidity and mortality rates are also increasing day by day as they have zoonotic importance. Anthelmintic drugs have been used for controlling these parasites; unfortunately, due to the development of resistance of these drugs in helminths (parasites), especially in three major classes like benzimidazoles, nicotinic agonists, and macrocyclic lactones, their use is becoming very low...
March 4, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38436002/a-review-on-the-traditional-uses-nutritive-importance-pharmacognostic-features-phytochemicals-and-pharmacology-of-momordica-cymbalaria-hook-f
#35
JOURNAL ARTICLE
Firdous Sayeed Mohammed, Dinesh Babu, Zainab Irfan, Marwa A A Fayed
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities. This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, morphology, therapeutic uses, nutritional values, pharmacognostic characters, phytochemicals, and pharmacological activities of MC. The available literature showed that MC fruits are utilized as a stimulant, tonic, laxative, stomachic, and to combat inflammatory disorders...
2024: PeerJ
https://read.qxmd.com/read/38434903/biophysical-analysis-of-potential-inhibitors-of-sars-cov-2-cell-recognition-and-their-effect-on-viral-dynamics-in-different-cell-types-a-computational-prediction-from-in-vitro-experimental-data
#36
JOURNAL ARTICLE
Lenin González-Paz, Carla Lossada, María Laura Hurtado-León, Joan Vera-Villalobos, José L Paz, Yovani Marrero-Ponce, Felix Martinez-Rios, Ysaías J Alvarado
Recent reports have suggested that the susceptibility of cells to SARS-CoV-2 infection can be influenced by various proteins that potentially act as receptors for the virus. To investigate this further, we conducted simulations of viral dynamics using different cellular systems (Vero E6, HeLa, HEK293, and CaLu3) in the presence and absence of drugs (anthelmintic, ARBs, anticoagulant, serine protease inhibitor, antimalarials, and NSAID) that have been shown to impact cellular recognition by the spike protein based on experimental data...
February 27, 2024: ACS Omega
https://read.qxmd.com/read/38431114/tegumental-surface-change-in-paramphistomum-epiclitum-caused-by-bombax-ceiba-flowers-and-black-pepper-seed-extract
#37
JOURNAL ARTICLE
Kulvadee Dolsophon, Sirapat Nak-On, Thapana Chontananarth
Rumen flukes, parasites of the superfamily Paramphistomoidea, are found in cattle rumen. Heavy infections can cause symptoms such as diarrhea, weight loss, and poor body condition, resulting in a decrease in milk and meat production. This study compares the tegumental surface change of Paramphistomum epiclitum as a response to ethanolic extracts of Bombax ceiba flowers and black pepper seeds. Adult flukes were subjected to various concentrations of crude extracts, including 12.5, 25, 50, 100, and 200 μg/mL for 12, 18, and 24 h incubation...
February 29, 2024: Experimental Parasitology
https://read.qxmd.com/read/38430622/performance-of-three-techniques-for-diagnosing-equine-tapeworm-infection
#38
JOURNAL ARTICLE
Hailey C Anderson, Shaelin F Warner, Nichol E Ripley, Martin K Nielsen
Tapeworm infection in horses can cause serious health concerns, and recent data have documented treatment failures in the most common species, Anoplocephala perfoliata. The threat of anthelmintic resistance in A. perfoliata is of particular concern because of poor diagnostic performance of standard egg counting techniques for detecting this parasite. This study compared the performance of three diagnostic techniques 1) Mini-FLOTAC, 2) Cornell-Wisconsin, and 3) Proudman and Edwards used to detect and quantify A...
February 24, 2024: Veterinary Parasitology
https://read.qxmd.com/read/38429820/multi-omics-data-elucidate-parasite-host-microbiota-interactions-and-resistance-to-haemonchus-contortus-in-sheep
#39
JOURNAL ARTICLE
Simone Cristina Méo Niciura, Tainã Figueiredo Cardoso, Adriana Mercia Guaratini Ibelli, Cintia Hiromi Okino, Bruno Gabriel Andrade, Magda Vieira Benavides, Ana Carolina de Souza Chagas, Sergio Novita Esteves, Alessandro Pelegrine Minho, Luciana Correia de Almeida Regitano, Cedric Gondro
BACKGROUND: The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance...
March 1, 2024: Parasites & Vectors
https://read.qxmd.com/read/38429804/phytochemical-analysis-and-anthelmintic-activity-of-combretum-mucronatum-leaf-extract-against-infective-larvae-of-soil-transmitted-helminths-including-ruminant-gastrointestinal-nematodes
#40
JOURNAL ARTICLE
François Ngnodandi Belga, Patrick Waindok, Marie-Kristin Raulf, Jonathan Jato, Emmanuel Orman, Steffen Rehbein, Verena Spiegler, Eva Liebau, Andreas Hensel, Dieudonné Ndjonka, Christina Strube
BACKGROUND: Soil-transmitted helminths (STH) infect more than a quarter of the world's human population. In the absence of vaccines for most animal and human gastrointestinal nematodes (GIN), treatment of infections primarily relies on anthelmintic drugs, while resistance is a growing threat. Therefore, there is a need to find alternatives to current anthelmintic drugs, especially those with novel modes of action. The present work aimed to study the composition and anthelmintic activity of Combretum mucronatum leaf extract (CMLE) by phytochemical analysis and larval migration inhibition assays, respectively...
March 1, 2024: Parasites & Vectors
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