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https://www.readbyqxmd.com/read/28926584/transcriptome-analysis-reveals-molecular-anthelmintic-effects-of-procyanidins-in-c-elegans
#1
Verena Spiegler, Andreas Hensel, Jochen Seggewiß, Milena Lubisch, Eva Liebau
Worldwide, more than 1 billion people are affected by infestations with soil-transmitted helminths and also in veterinary medicine helminthiases are a severe threat to livestock due to emerging resistances against the common anthelmintics. Proanthocyanidins have been increasingly investigated for their anthelmintic properties, however, except for an interaction with certain proteins of the nematodes, not much is known about their mode of action. To investigate the anthelmintic activity on a molecular level, a transcriptome analysis was performed in Caenorhabditis elegans after treatment with purified and fully characterized oligomeric procyanidins (OPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28917324/targeted-anthelmintic-treatment-of-parasitic-gastroenteritis-in-first-grazing-season-dairy-calves-using-daily-live-weight-gain-as-an-indicator
#2
A Jackson, K A Ellis, J McGoldrick, N N Jonsson, M J Stear, A B Forbes
Control of parasitic gastroenteritis in cattle is typically based on group treatments with anthelmintics, complemented by grazing management, where feasible. However, the almost inevitable evolution of resistance in parasitic nematodes to anthelmintics over time necessitates a reappraisal of their use in order to reduce selection pressure. One such approach is targeted selective treatment (TST), in which only individual animals that will most benefit are treated, rather than whole groups of at-risk cattle. This study was designed to assess the feasibility of implementing TST on three commercial farms, two of which were organic...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917315/protective-and-risk-factors-associated-with-the-presence-of-toxocara-spp-eggs-in-dog-hair
#3
Yslla Fernanda Fitz Balo Merigueti, Vamilton Alvares Santarém, Lívia Magosso Ramires, Aline da Silveira Batista, Layron Vinícus da Costa Beserra, Amábyle Lopes Nuci, Talita Mirella de Paula Esposte
Toxocariasis is one of the most prevalent parasitic zoonoses in the world. The disease is principally caused by the nematode Toxocara canis, whose definitive host is the dog. The transmission of toxocariasis to humans is mainly caused by accidental ingestion of embryonated eggs of the parasite, present in the soil. Studies have shown that dog hair has the capacity to harbor eggs of the parasite and represents a risk for transmission of the zoonosis. The objective of the present study was to evaluate the frequency and factors associated with the contamination of dog hair by Toxocara spp...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917310/screening-of-a-small-well-curated-natural-product-based-library-identifies-two-rotenoids-with-potent-nematocidal-activity-against-haemonchus-contortus
#4
H M P Dilrukshi Herath, Sarah Preston, Andreas Hofmann, Rohan A Davis, Anson V Koehler, Bill C H Chang, Abdul Jabbar, Robin B Gasser
The control of parasitic roundworms (nematodes) is heavily reliant on the use of a limited number of anthelmintic drugs. However, drug resistance is now very widespread and no vaccines are available, such that the discovery of new chemical entities is crucial. Within this context, we screened a library of pure natural products (n=400) against exsheathed third-stage (xL3) larvae of the parasitic nematode Haemonchus contortus using a whole-organism screening method. We identified two plant-derived rotenoids, deguelin and rotenone, with inhibitory activity on xL3 motility...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28916697/reclassification-of-sheep-anthelmintic
#5
John Fishwick, Kathryn Dun
No abstract text is available yet for this article.
September 16, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28916696/reclassification-of-sheep-anthelmintic
#6
Chris Lewis
No abstract text is available yet for this article.
September 16, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28911536/biopharmaceutical-potentials-of-prosopis-spp-mimosaceae-leguminosa
#7
REVIEW
Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang Rong Chang
Prosopis is a commercially important plant genus, which has been used since ancient times, particularly for medicinal purposes. Traditionally, Paste, gum, and smoke from leaves and pods are applied for anticancer, antidiabetic, anti-inflammatory, and antimicrobial purposes. Components of Prosopis such as flavonoids, tannins, alkaloids, quinones, or phenolic compounds demonstrate potentials in various biofunctions, such as analgesic, anthelmintic, antibiotic, antiemetic, microbial antioxidant, antimalarial, antiprotozoal, antipustule, and antiulcer activities; enhancement of H(+), K(+), ATPases; oral disinfection; and probiotic and nutritional effects; as well as in other biopharmaceutical applications, such as binding abilities for tablet production...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28902487/angiostrongylus-cantonensis-agent-of-a-sometimes-fatal-globally-emerging-infectious-disease-rat-lungworm-disease
#8
Robert H Cowie
Angiostrongylus cantonensis, the rat lungworm, is a dangerous invasive species that is the agent of a potentially fatal globally emerging infectious disease. Humans are infected most commonly by ingestion, deliberately or inadvertently, of the parasite larvae in their intermediate snail hosts. The larvae make their way to the brain where they can cause severe neurological damage before eventually dying. Symptoms of the disease are diverse, making it difficult to diagnose. Treatment is primarily with corticosteroids to reduce inflammation, while treatment with anthelmintics to kill the worms remains controversial...
September 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28895238/the-use-of-1-h-nmr-metabolomics-to-optimise-the-extraction-and-preliminary-identification-of-anthelmintic-products-from-the-leaves-of-lysiloma-latisiliquum
#9
Gloria Ivonne Hernández-Bolio, Erika Kutzner, Wolfgang Eisenreich, Juan Felipe de Jesús Torres-Acosta, Luis Manuel Peña-Rodríguez
INTRODUCTION: Tannin-rich forages are recognised as an important alternative for the control of gastrointestinal nematodes in small ruminants. Lysiloma latisiliquum, a forage commonly consumed by goats and sheep, has shown anthelmintic activity when tested against Haemonchus contortus. However, to date, the metabolites responsible for the activity are not known. OBJECTIVE: To use (1) H-NMR metabolomics in the extraction and identification of anthelmintic metabolites from L...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28892494/infections-by-human-gastrointestinal-helminths-are-associated-with-changes-in-faecal-microbiota-diversity-and-composition
#10
Timothy P Jenkins, Yasara Rathnayaka, Piyumali K Perera, Laura E Peachey, Matthew J Nolan, Lutz Krause, Rupika S Rajakaruna, Cinzia Cantacessi
Investigations of the impact that patent infections by soil-transmitted gastrointestinal nematode parasites exert on the composition of the host gut commensal flora are attracting growing interest by the scientific community. However, information collected to date varies across experiments, and further studies are needed to identify consistent relationships between parasites and commensal microbial species. Here, we explore the qualitative and quantitative differences between the microbial community profiles of cohorts of human volunteers from Sri Lanka with patent infection by one or more parasitic nematode species (H+), as well as that of uninfected subjects (H-) and of volunteers who had been subjected to regular prophylactic anthelmintic treatment (Ht)...
2017: PloS One
https://www.readbyqxmd.com/read/28891678/prevalence-of-gastrointestinal-helminth-infections-in-free-range-laying-hens-under-mountain-farming-production-conditions
#11
K Wuthijaree, C Lambertz, M Gauly
1. A cross-sectional study was conducted from September 2015 to July 2016 in South Tyrol, Northern Italy to examine the prevalence of gastrointestinal helminths in free-range laying hens under mountain farming production conditions. 2. A total of 280 laying hens from 14 free-range mountain farms (4 organic, 10 conventional) were randomly collected at the end of the laying period. Faecal samples were taken to analyse faecal egg counts (FEC) and faecal oocyst counts (FOC). The gastrointestinal tracts were removed post mortem and examined for the presence of helminths...
September 11, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28887230/multiparticulate-system-combining-taste-masking-and-immediate-release-properties-for-the-aversive-compound-praziquantel
#12
Magdalena Münster, Corinna Schoch, Carsten Schmidt, Jörg Breitkreutz
The taste of pharmaceuticals is of particular importance as it highly affects the compliance of patients, especially for patient groups like children. In view of oral solid dosage forms, various taste masking techniques can be applied encapsulating the active pharmaceutical ingredient (API) to prevent the interaction with the taste buds. Despite a delayed drug release in saliva, an immediate drug release in gastrointestinal media is desirable for efficient drug absorption. This combinatory approach is of particular interest for poorly soluble drugs still demonstrating an aversive, bitter taste, e...
September 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28885590/ethnopharmacology-and-therapeutic-value-of-bridelia-micrantha-hochst-baill-in-tropical-africa-a-comprehensive-review
#13
REVIEW
Alfred Maroyi
Bridelia micrantha is traditionally used in tropical Africa to treat a wide range of human and animal diseases. The aim of this study was to summarise the research that has been done on the ethnomedicinal uses, phytochemistry and pharmacological properties of B. micrantha so as to understand its importance and potential value in primary healthcare systems. The literature search for information on ethnomedicinal uses and pharmacological activities of B. micrantha was undertaken using databases such as Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), PubMed and Springerlink...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28883809/recent-research-progress-in-china-on-haemonchus-contortus
#14
REVIEW
Chunqun Wang, Fangfang Li, Zongze Zhang, Xin Yang, Awais A Ahmad, Xiangrui Li, Aifang Du, Min Hu
Haemonchus contortus is one of the most important parasites of ruminants with worldwide distribution that can bring huge economic losses to the breeding industry of cattle, sheep, and goats. In recent 20 years, studies on H. contortus in China mainly focused on the epidemiology, population genetics, anthelmintic resistance, structural and functional studies of important genes regulating the development of this parasite, interaction between parasite molecules and host cells and vaccine development against haemonchosis, and achieved good progress...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28864506/vets-extremely-concerned-about-reclassification-of-sheep-anthelmintic
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28864027/efficacy-and-safety-of-tribendimidine-tribendimidine-plus-ivermectin-tribendimidine-plus-oxantel-pamoate-and-albendazole-plus-oxantel-pamoate-against-hookworm-and-concomitant-soil-transmitted-helminth-infections-in-tanzania-and-c%C3%A3-te-d-ivoire-a-randomised-controlled
#16
Wendelin Moser, Jean T Coulibaly, Said M Ali, Shaali M Ame, Amour K Amour, Richard B Yapi, Marco Albonico, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Preventive chemotherapy is the current strategy to control soil-transmitted helminth infections (caused by Ascaris lumbricoides, hookworm, and Trichuris trichiura). But, to improve efficacy and avoid emerging resistance, new drugs are warranted. Tribendimidine has shown good anthelmintic efficacy and is therefore a frontrunner for monotherapy and combination chemotherapy. METHODS: We did a randomised, controlled, single-blinded, non-inferiority trial on Pemba Island, Tanzania, and in Côte d'Ivoire...
August 29, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28863133/spatial-distribution-and-risk-factors-of-schistosoma-haematobium-and-hookworm-infections-among-schoolchildren-in-kwale-kenya
#17
Evans Asena Chadeka, Sachiyo Nagi, Toshihiko Sunahara, Ngetich Benard Cheruiyot, Felix Bahati, Yuriko Ozeki, Manabu Inoue, Mayuko Osada-Oka, Mayuko Okabe, Yukio Hirayama, Mwatasa Changoma, Keishi Adachi, Faith Mwende, Mihoko Kikuchi, Risa Nakamura, Yombo Dan Justin Kalenda, Satoshi Kaneko, Kenji Hirayama, Masaaki Shimada, Yoshio Ichinose, Sammy M Njenga, Sohkichi Matsumoto, Shinjiro Hamano
BACKGROUND: Large-scale schistosomiasis control programs are implemented in regions with diverse social and economic environments. A key epidemiological feature of schistosomiasis is its small-scale heterogeneity. Locally profiling disease dynamics including risk factors associated with its transmission is essential for designing appropriate control programs. To determine spatial distribution of schistosomiasis and its drivers, we examined schoolchildren in Kwale, Kenya. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional study of 368 schoolchildren from six primary schools...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28861721/influence-of-parasitic-worm-infections-on-allergy-diagnosis-in-sub-saharan-africa
#18
REVIEW
Abena S Amoah, Daniel A Boakye, Maria Yazdanbakhsh, Ronald van Ree
Epidemiological studies from Sub-Saharan Africa indicate that allergies are on the rise in this region especially in urban compared to rural areas. This increase has been linked to improved hygiene, lifestyle changes, and lower exposure to pathogens in childhood. Reduced exposure to parasitic worm (helminth) infections and allergy outcomes has been the focus of a number of population studies over the years. Paradoxically, there are parallels in the immune responses to helminths and to allergies. Both conditions are associated with elevated levels of immunoglobulin E, high numbers of T helper 2 cells, eosinophils, and mast cells...
September 1, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28861168/inhibition-of-wnt-%C3%AE-catenin-by-anthelmintic-drug-niclosamide-effectively-targets-growth-survival-and-angiogenesis-of-retinoblastoma
#19
Zhi Li, Qin Li, Genguo Wang, Yi Huang, Xiaochun Mao, Yanfang Zhang, Xueyan Wang
Retinoblastoma is an angiogenesis-dependent ocular tumor, the clinical management of which remains a challenge. Agents that can target tumor cells and angiogenesis, as well as augment current chemotherapy efficacy, present a promising therapeutic strategy for retinoblastoma. We demonstrated that niclosamide, an FDA-approved anthelmintic drug, is effective against multiple aspects of retinoblastoma. Niclosamide inhibited proliferation via causing cell cycle arrest at the G2/M phase and induced caspase-dependent apoptosis in a panel of retinoblastoma cell lines, including Y79, RB116, and WERI-Rb-1...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28843101/modelling-the-impact-of-targeted-anthelmintic-treatment-of-cattle-on-dung-fauna
#20
Andrew S Cooke, Eric R Morgan, Jennifer A J Dungait
The insecticidal properties of many anthelmintics pose a risk to dung fauna through the effects of drug residues in dung on the activity, oviposition and development of dung-dwelling invertebrates. Reductions in dung fauna numbers can inhibit dung degradation, which may impact biodiversity and nutrient cycling on farms. A simulation model was created to predict the impact of antiparasitic drugs on cattle dung fauna, and calibrated using published data on the dung-breeding fly Scathophaga stercoraria. This model was then tested under different effective dung drug concentrations (EC) and proportions of treated cattle (PT) to determine the impact under different application regimens...
August 7, 2017: Environmental Toxicology and Pharmacology
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