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https://www.readbyqxmd.com/read/28728358/tropical-plant-supplementation-effects-on-the-performance-and-parasite-burden-of-goats
#1
Juan Jose Romero, Miguel Augusto Zarate, Ibukun M Ogunade, Kathy G Arriola, Adegbola Tolulope Adesogan
Objective: Examine the effects of supplementing bahiagrass hay (BG) with potentially anthelmintic quantities of hays of perennial peanut (PEA) or sericea lespedeza (LES) or seeds of velvet bean (MUC) or papaya (PAP) on the intake and nutritive value (Experiment 1), and the performance and parasite burden (Experiment 2) of goats. Methods: In experiment 1, 38 male goats (27.4 ± 5.7 kg BW) were randomly assigned to each of 5 treatments: 1) BG alone and BG plus 2) PEA; 3) LES; 4) MUC; and 5) PAP...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28725631/biological-activities-and-medicinal-properties-of-asafoetida-a-review
#2
REVIEW
Augustine Amalraj, Sreeraj Gopi
Ferula asafoetida Linn. is a main source of asafoetida, a strong, tenacious and sulfurous odor, and oleo-gum resin of medicinal and nutritional importance. Asafoetida has been consumed as a spice and a folk medicine for centuries. Recent studies have shown several promising activities particularly relaxant, neuroprotective, memory enhancing, digestive enzyme, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, anticarcinogenic, anticancer, anticytotoxicity, antiobesity, anthelmintic and antagonistic effect...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28721301/synthesis-and-characterization-of-n-mannich-based-prodrugs-of-ciprofloxacin-and-norfloxacin-in-vitro-anthelmintic-and-cytotoxic-evaluation
#3
Mona Piplani, Harish Rajak, Prabodh Chander Sharma
Prodrugs, the inert derivatives of existing drugs have successfully contributed to the modification of their physicochemical properties. The improved antimicrobial potential due to enhanced lipophilicity of some of the synthesized prodrugs of antibacterial agents by various schemes has already been reported. In the current study, synthesis, characterization, and biological evaluation of some more lipid based prodrugs/compounds of ciprofloxacin and norfloxacin has been carried out. The synthesized prodrugs/compounds have been screened for anthelmintic activity using Indian earthworms and cytotoxic activity against human lung cancer cell lines A-549 employing sulforhodamine B (SRB) assay method...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28717849/an-assessment-of-benzimidazole-resistance-against-caprine-nematodes-in-central-india
#4
A K Dixit, G Das, Pooja Dixit, A P Singh, N K Kumbhakar, M Sankar, R L Sharma
Current status of resistance to benzimidazole (BZ) group of anthelmintic drugs against caprine nematodes in Central India at Amanala goat farm, Jabalpur, Madhya Pradesh (M. P.), was systematically investigated using faecal egg count reduction (FECR) test and egg hatch test (EHT). Besides, allele-specific PCR (AS-PCR) was deployed to ascertain the susceptible genotype (alleles) especially of the Haemonchus contortus. Randomly selected 30 goats, irrespective of age and sex, were divided into three groups of 10 each, to serve as treated and untreated controls...
July 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28716205/attitudes-towards-worm-egg-counts-and-targeted-selective-treatment-against-equine-cyathostomins
#5
H Rose Vineer, F Vande Velde, K Bull, E Claerebout, E R Morgan
Gastrointestinal nematodes present a major threat to the health and welfare of equids worldwide. Anthelmintic resistance (AR) is increasingly reported and challenges effective control in horses and ponies in many regions. The use of faecal worm egg counts (FECs) to support targeted treatment (FEC-TT) and targeted selective treatment (FEC-TST) has been promoted as an effective deworming strategy that may prolong the useful life of anthelmintics and reduce the costs associated with parasite control. However, treatment applied at set intervals or on pre-determined dates remains common...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28710734/multi-class-determination-of-pharmaceuticals-in-wastewaters-by-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry-with-matrix-effect-study
#6
Mirta Čizmić, Sandra Babić, Marija Kaštelan-Macan
In this work, a multi-class analytical method for determination of 22 frequently used pharmaceuticals was developed and validated. Analytes were from different classes for example macrolides, fluoroquinolones, tetracyclines, sulfonamides, anthelmintics, anesthetics, and others. Method was intended for analysis of aqueous samples so the sample preparation was done using solid-phase extraction (SPE). Different sorbents (C8, C18, polymeric, and ion exchange sorbents) combining different eluents (methanol, ethanol, acetonitrile, acetone, ethyl acetate) were investigated during development of sample preparation step...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28705749/in-vitro-effect-of-metrifonate-on-the-indices-of-oxidative-stress-in-gigantocotyle-explanatum
#7
Mohammad Ahmad, Murad A Mubaraki, Mohammed Ali M Marie
Helminth infections in general and digenetic trematodes in particular cause a huge economic loss globally to our livestock. Gigantocotyle explanatum is a digenetic amphistome that infects the bile ducts of water buffalo and are highly prevalent in tropical and sub-tropical countries. In the present study, effects of an organophosphate compound, Metrifonate (MF) in three doses, viz., 9.4 × 10(-5) M (Dose I), 14.4 × 10(-5) M (Dose II), and 19.4 × 10(-5) M (Dose III), have been studied in vitro, on the motility and on some enzymatic and non-enzymatic oxidative stress indices in G...
July 10, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28704396/phenotypic-chemical-and-functional-characterization-of-cyclic-nucleotide-phosphodiesterase-4-pde4-as-a-potential-anthelmintic-drug-target
#8
Thavy Long, Liliana Rojo-Arreola, Da Shi, Nelly El-Sakkary, Kurt Jarnagin, Fernando Rock, Maliwan Meewan, Alberto A Rascón, Lin Lin, Katherine A Cunningham, George A Lemieux, Larissa Podust, Ruben Abagyan, Kaveh Ashrafi, James H McKerrow, Conor R Caffrey
BACKGROUND: Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel drugs to treat a range of chronic indications including asthma, chronic obstructive pulmonary disease and Alzheimer's disease. One class of huPDE4 inhibitors that have yielded marketed drugs is the benzoxaboroles (Anacor Pharmaceuticals)...
July 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28702376/nematode-species-identification-current-status-challenges-and-future-perspectives-for-cyathostomins
#9
Christina M Bredtmann, Jürgen Krücken, Jayaseelan Murugaiyan, Tetiana Kuzmina, Georg von Samson-Himmelstjerna
Human and animal health is globally affected by a variety of parasitic helminths. The impact of co-infections and development of anthelmintic resistance requires improved diagnostic tools, especially for parasitic nematodes e.g., to identify resistant species or attribute pathological effects to individual species or particular species combinations. In horses, co-infection with cyathostomins is rather a rule than an exception with typically 5 to 15 species (out of more than 40 described) per individual host...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28697451/reduced-efficacy-of-albendazole-against-ascaris-lumbricoides-in-rwandan-schoolchildren
#10
Jürgen Krücken, Kira Fraundorfer, Jean Claude Mugisha, Sabrina Ramünke, Kevin C Sifft, Dominik Geus, Felix Habarugira, Jules Ndoli, Augustin Sendegeya, Caritas Mukampunga, Claude Bayingana, Toni Aebischer, Janina Demeler, Jean Bosco Gahutu, Frank P Mockenhaupt, Georg von Samson-Himmelstjerna
Control of human soil-transmitted helminths (STHs) relies on preventive chemotherapy of schoolchildren applying the benzimidazoles (BZ) albendazole or mebendazole. Anthelmintic resistance (AR) is a common problem in nematodes of veterinary importance but for human STHs, information on drug efficacy is limited and routine monitoring is rarely implemented. Herein, the efficacy of single dose albendazole (400 mg) was evaluated in 12 schools in the Huye district of Rwanda where Ascaris is the predominant STH. Ascaris eggs were detected by wet mount microscopy and the Mini-FLOTAC method to assess cure rate (CR) and faecal egg count reduction (FECR)...
June 23, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28695609/pharmaco-parasitological-evaluation-of-the-ricobendazole-plus-levamisole-nematodicidal-combination-in-cattle
#11
C Canton, L Ceballos, M P Domínguez, L Moreno, C Fiel, G Bernat, C Farías, C Lanusse, L Alvarez
The goals of the current study were to evaluate the potential pharmacokinetic (PK) interactions and the clinical efficacy occurring after the subcutaneous (s.c.) administration of ricobendazole (RBZ) and levamisole (LEV) given both separately and co-administered to calves naturally infected with susceptible gastrointestinal nematodes. The clinical efficacy was shown in two seasons, winter and spring, with predominance of different nematode populations. Groups of 15 calves were treated with RBZ alone, LEV alone and RBZ + LEV combination, and an untreated group was kept as a Control...
July 10, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28689247/loop-mediated-isothermal-amplification-as-a-reliable-assay-for-toxocara-canis-infection-in-pet-dogs
#12
Paria Khoshakhlagh, Adel Spotin, Mahmoud Mahami-Oskouei, Abbas Shahbazi, Maryam Ozlati
Keeping of infected dogs as pet results in the potential transmission risk factors for shedding helminthic infections such as toxocariasis. Lack of accurate identification of Toxocara canis eggs in non-dewormed infected pet dogs remains a diagnostic concern among researchers. In this study, dog owners were asked to fill up a questionnaire regarding their pets and their attitude towards the deworming regimen. One hundred faecal samples were collected from pet dogs (Northwest Iran) and were subsequently identified by the ZnSo4 flotation technique, PCR and loop-mediated isothermal amplification (LAMP) assays...
July 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28687609/deguelin-exerts-potent-nematocidal-activity-via-the-mitochondrial-respiratory-chain
#13
Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan R E Ansell, Gillian M Fisher, Katherine T Andrews, Bill C H Chang, Martin A M Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selectively and potently inhibits the motility and development of nematodes, which supports its potential as a lead candidate for drug development. Furthermore, we demonstrate that deguelin treatment significantly increases gene transcription that is associated with energy metabolism, particularly oxidative phosphorylation and mito-ribosomal protein production before inhibiting motility...
July 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28673613/parkinsonism-and-other-movement-disorders-in-23-cases-of-neurocysticercosis
#14
Fernando Alarcón, Yuri Cedeño, Justo García de Yébenes
INTRODUCTION: Parkinsonism and other movement disorders have been occasionally described in neurocysticercosis (NCC) but their clinical features and pathogenesis are not well understood. METHODS: This is a descriptive study conducted over 20 years. We studied 590 consecutive patients from the NCC Registry at Eugenio Espejo Hospital, Quito, Ecuador, and found 23 subjects who developed movement disorders. We investigated the clinical features, localization of brain lesions, severity of infection and neurological deficit as well as the outcome of the patients...
June 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28651981/synthesis-and-anthelmintic-activity-of-arctigenin-derivatives-against-dactylogyrus-intermedius-in-goldfish
#15
Yang Hu, Lei Liu, Guang-Lu Liu, Xiao Tu, Gao-Xue Wang, Fei Ling
To control the parasitic disease of Dactylogyrus intermedius, a series of new arctigenin derivatives were designed, synthesized and tested in our study. The anthelmintic activity of most of the derivatives ranged from 1 to 10mg/L. Compared to traditional drug praziquantel (EC50=2.69mg/L), ether derivatives 2g and 2h exhibited slightly higher anti-parasitic activity, with the EC50 values of 2.48 and 1.52mg/L, respectively. Furthermore, the arctigenin-imidazole hybrids 4a and 4b also removed D. intermedius effectively, with the EC50 values of 2...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28650175/bioactive-peptide-natural-products-as-lead-structures-for-medicinal-use
#16
Tam Dang, Roderich D Süssmuth
The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived natural products have been isolated from bacteria and fungi. Hence, microorganisms play a pivotal role as sources for novel drugs with an emphasis on anti-infective agents. Various disciplines from biology, chemistry, and medicine are involved in early stages of the search for peptide natural products including taxonomy, microbiology, bioanalytics, bioinformatics, and medicinal chemistry...
June 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28647509/a-review-of-acalypha-indica-l-euphorbiaceae-as-traditional-medicinal-plant-and-its-therapeutic-potential
#17
REVIEW
Nor Syahiran Zahidin, Syafiqah Saidin, Razauden Mohamed Zulkifli, Ida Idayu Muhamad, Harisun Ya'akob, Hadi Nur
ETHNOPHARMACOLOGICAL RELEVANCE: Acalypha indica is an herbal plant that grows in wet, temperate and tropical region, primarily along the earth's equator line. This plant is considered by most people as a weed and can easily be found in these regions. Although this plant is a weed, Acalypha indica has been acknowledged by local people as a useful source of medicine for several therapeutic treatments. They consume parts of the plant for many therapeutics purposes such as anthelmintic, anti-ulcer, bronchitis, asthma, wound healing, anti-bacterial and other applications...
June 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28647171/worm-control-in-livestock-bringing-science-to-the-field
#18
REVIEW
Fiona Kenyon, Fiona Hutchings, Claire Morgan-Davies, Jan van Dijk, Dave J Bartley
Parasitic roundworm infections are ubiquitous in grazing livestock. Chemical control through the frequent 'blanket' administration of anthelmintics (wormers) has been, and remains, the cornerstone in controlling these infections, but this practice is unsustainable. Alternative strategies are available but, even with the plethora of best practice advice available, have yet to be integrated into routine farming practice. This is probably due to a range of factors, including contradictory advice from different sources, changes to advice following increased scientific understanding, and top-down knowledge exchange patterns...
June 21, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28644839/genomic-introgression-mapping-of-field-derived-multiple-anthelmintic-resistance-in-teladorsagia-circumcincta
#19
Young-Jun Choi, Stewart A Bisset, Stephen R Doyle, Kymberlie Hallsworth-Pepin, John Martin, Warwick N Grant, Makedonka Mitreva
Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to drug resistance. Given that the genetic architecture of resistance is poorly understood for any nematode, we have analyzed multidrug resistant Teladorsagia circumcincta, a major parasite of sheep, as a model for analysis of resistance selection. We introgressed a field-derived multiresistant genotype into a partially inbred susceptible genetic background (through repeated backcrossing and drug selection) and performed genome-wide scans in the backcross progeny and drug-selected F2 populations to identify the major genes responsible for the multidrug resistance...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28632749/using-a-health-rating-system-to-evaluate-the-usefulness-of-caenorhabditis-elegans-as-a-model-for-anthelmintic-study
#20
Kathryn J Weaver, Cassandra J May, Brian L Ellis
Soil-transmitted helminths (STHs) are intestinal parasitic nematodes that infect humans, and are transmitted through contaminated soil. These nematodes include the large roundworm (Ascaris lumbricoides), whipworm (Trichuris trichiura), and hookworm (Ancylostoma ceylanicum, Ancylostoma duodenale, and Necator americanus). Nearly 1.5 billion people (~24% of the population) worldwide are infected with at least one species of these parasites, burdening the poor, in particular, children and pregnant women. To combat these diseases, the WHO only recognizes four anthelmintic drugs, including the preferred drug, albendazole, for mass drug administration (MDA)...
2017: PloS One
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