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lung cancer spinal metastasis

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https://www.readbyqxmd.com/read/27820732/a-rare-intramedullary-spinal-cord-metastasis-from-a-retroperitoneal-leiomyosarcoma-presenting-as-a-non-traumatic-spinal-cord-injury
#1
Andrew Lamberth Parker, Terrence Pugh, Mark A Hirsch
Leiomyosarcoma (LMS) is a rare but well-recognized malignant soft tissue sarcoma of smooth muscle origin. Metastases commonly occur in the lungs, liver, kidney, brain, and bone. Cases of metastatic osseous lesions or other extradural space-occupying masses secondary to LMS leading to neurologic compromise are relatively commonplace in the literature. Conversely, cases of intramedullary spinal cord metastasis (ISCM), an unusual entity as a sequela of any cancer, are exceedingly rare as a consequence of LMS. Only 2 cases of an ISCM from LMS are currently documented in the literature, and to the best of our knowledge, no case is described in the rehabilitation literature...
November 4, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27797240/prevalence-and-survival-patterns-of-patients-with-bone-metastasis-from-common-cancers-in-thailand
#2
Areerak Phanphaisarn, Jayantorn Patumanond, Jongkolnee Settakorn, Parunya Chaiyawat, Jeerawan Klangjorhor, Dumnoensun Pruksakorn
BACKGROUND: Bone metastasis is a single condition but presents with various patterns and severities. Skeletal- related events (SREs) deteriorate overall performance status and reduce quality of life. However, guidelines for early detection and management are limited. This study includes a survey of the prevalence of bone metastasis in cases with common cancers in Thailand as well as a focus on survival patterns and SREs. MATERIALS AND METHODS: A retrospective cohort analysis was conducted using a database of the Chiang Mai Cancer Registry and the Musculoskeletal Tumor Registry of the OLARN Center, Chiang Mai University...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27768024/our-experience-in-the-treatment-of-vertebral-metastases-from-renal-cell-carcinoma-a-retrospective-study
#3
Giulia R Mosele, Gianfilippo Caggiari, Roberto M Scarpa, Carlo Doria
BACKGROUND: Renal cell carcinoma (RCC) is among the 10 most common cancers in both men and women. It comprises 2-3% of all malignancies. The most common site for metastasis from RCC is the lung (50% of patients), followed by the skeleton (20% to 50% of patients). METHODS: We retrospectively reviewed our consecutive series of 63 patients surgically treated for spinal metastases from RCC. The surgical treatment for spinal metastases varied in each patient. Factors influencing the choice of surgery included age, disease status, symptoms, morbidity of the patient, the location, the number of repetitive lesions and the existence of extra-osseous metastases...
October 21, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27621899/a-case-of-long-term-survival-after-multimodal-local-treatments-of-intramedullary-spinal-cord-metastasis-of-squamous-cell-lung-cancer
#4
Shojiro Minomo, Akihiro Tokoro, Tomoki Utsumi, Masahiro Ishihara, Masanori Akira, Shinji Atagi
Intramedullary spinal cord metastasis of non-small cell lung cancer is rare, and it has a short prognosis. We report a 53-year-old man diagnosed with cT4N0M0, stage IIIA squamous cell lung cancer. Ten months after left pneumonectomy (pT4N0M0), an intramedullary spinal cord tumor developed at the axis level. The intramedullary spinal cord tumor was resected, and he was diagnosed with metastatic squamous cell lung cancer. Radiotherapies and another tumor resection were conducted, as he had a good performance status and the discrete lesion was associated with the risk of brain stem compression...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27614511/-stereotactic-body-radiation-therapy-for-spinal-metastases
#5
D Pasquier, G Martinage, X Mirabel, T Lacornerie, S Makhloufi, J-C Faivre, S Thureau, É Lartigau
After the liver and lungs, bones are the third most common sites of cancer metastasis. Palliative radiotherapy for secondary bone tumours helps relieve pain, improve the quality of life and reduce the risk of fractures. Stereotactic body radiotherapy can deliver high radiation doses with very tight margins, which has significant advantages when treating tumours close to the spinal cord. Strict quality control is essential as dose gradient at the edge of the spinal cord is important. Optimal schedule is not defined...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27559455/comparison-of-magnetic-resonance-imaging-findings-between-pathologically-proven-cases-of-atypical-tubercular-spine-and-tumour-metastasis-a-retrospective-study-in-40-patients
#6
Somit Mittal, Mohd Khalid, Aamir Bin Sabir, Saifullah Khalid
STUDY DESIGN: Retrospective study. PURPOSE: To note the magnetic resonance imaging (MRI) differences between pathologically proven cases of atypical spinal tuberculosis and spinal metastasis in 40 cases. OVERVIEW OF LITERATURE: Spinal tuberculosis, or Pott's spine, constitutes less than 1% of all cases of tuberculosis and can be associated with a neurologic deficit. Breast, prostate and lung cancer are responsible for more than 80% of metastatic bone disease cases, and spine is the most common site of bone metastasis...
August 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27544340/development-of-a-metastatic-spinal-tumor-frailty-index-mstfi-using-a-nationwide-database-and-its-association-with-inpatient-morbidity-mortality-and-length-of-stay-after-spine-surgery
#7
Rafael De la Garza Ramos, C Rory Goodwin, Amit Jain, Nancy Abu-Bonsrah, Charles G Fisher, Chetan Bettegowda, Daniel M Sciubba
OBJECTIVE: The aim of this study was to develop a perioperative metastatic spinal tumor frailty index (MSTFI) which could predict morbidity, mortality, and length of stay. METHODS: A large inpatient hospitalization database was searched from 2002-2011 to identify 4,583 patients with spinal metastasis from breast (21.1%), lung (34.1%), thyroid (3.8%), renal (19.9%) and prostate (21.1%) cancer who underwent surgery. A multiple logistic regression model identified nine independent parameters that were used to construct the MSTFI: anemia, chronic lung disease, coagulopathy, electrolyte abnormalities, pulmonary circulation disorders, renal failure, malnutrition, emergent/urgent admission, and anterior/combined surgical approach...
August 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27476836/application-of-morphometric-analysis-to-patients-with-lung-cancer-metastasis-to-the-spine-a-clinical-study
#8
Hesham Mostafa Zakaria, Azam Basheer, David Boyce-Fappiano, Erinma Elibe, Lonni Schultz, Ian Lee, Farzan Siddiqui, Brent Griffith, Victor Chang
OBJECTIVE Predicting the survival rate for patients with cancer is currently performed using the TNM Classification of Malignant Tumors (TNM). Identifying accurate prognostic markers of survival would allow better treatment stratification between more aggressive treatment strategies or palliation. This is especially relevant for patients with spinal metastases, who all have identical TNM staging and whose surgical decision-making is potentially complex. Analytical morphometrics quantifies patient frailty by measuring lean muscle mass and can predict risk for postoperative morbidity after lumbar spine surgery...
August 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27456003/survival-and-prognostic-factors-in-patients-with-stable-and-unstable-spinal-bone-metastases-from-solid-tumors-a-retrospective-analysis-of-915-cases
#9
Robert J Wolf, Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus, Harald Rief, German Bone Research Group
BACKGROUND: Adequate prediction of survival plays an important role in treatment decisions for patients with spinal bone metastases (SBM). Several prognostic factors are already used in daily clinical practice, but factors related to stability of SBM are still unknown. Therefore, we designed this study to identify these prognostic factors. METHODS: We retrospectively assessed 915 patients from solid tumors with commonly metastased into the bone treated at our department between January 2000 and January 2012...
July 25, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27350194/-effect-of-p2x7-receptor-knock-out-on-bone-cancer-pain-in-mice
#10
Xin Zhao, Hui-Zhu Liu, Yu-Qiu Zhang
Cancer pain is one of the most common symptoms in patients with late stage cancer. Lung, breast and prostate carcinoma are the most common causes of pain from osseous metastasis. P2X7 receptor (P2X7R) is one of the subtypes of ATP-gated purinergic ion channel family, predominately distributed in microglia in the spinal cord. Activation of P2X7Rs in the spinal dorsal horn has been associated with release of proinflammatory cytokines from glial cells, causing increased neuronal excitability and exaggerated nociception...
June 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27335712/when-evaluating-a-new-thyroid-mass-and-a-ring-enhancing-brain-lesion-when-two-presentations-collide
#11
Zachary Nicholas, Michael Sughrue, James Battiste, Ozer Algan
We aimed to evaluate the clinical and pathologic features of two common medical illnesses and their appropriate workup and pathognomonic findings. A 57-year-old white male presented with a new onset expressive aphasia while traveling abroad. He was evaluated at an outside facility and underwent workup for a stroke. The evaluation included a CT and MRI of the brain demonstrating three new enhancing lesions, the largest of which was a 2.5 cm ring-enhancing cystic lesion. A CT of the chest noted a 4-cm cystic thyroid lesion that was diagnosed as a thyroid cancer with brain metastases...
2016: Curēus
https://www.readbyqxmd.com/read/27277163/thoracic-laminectomy-with-spinal-fixation-in-a-nonambulatory-patient-with-metastatic-vertebral-tumor-from-endometrial-carcinoma
#12
Sho Takeshita, Yukiharu Todo, Kazuhira Okamoto, Shinichiro Minobe, Hidenori Kato
Vertebral metastasis from endometrial cancer is a rare event and requires emergency treatment at the onset of neurologic symptoms caused by spinal cord compression. We report a case of a metastatic vertebral tumor, according to the International Federation of Gynecology and Obstetrics classification, of stage IVb endometrial cancer with multiple lung metastases. Emergency irradiation to the spinal tumor was conducted as a result of a loss of ambulation. Thoracic laminectomy with spinal fixation was subsequently performed because the patient remained nonambulatory and her neurological function deteriorated...
June 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27243238/concurrent-radiotherapy-and-intrathecal-methotrexate-for-treating-leptomeningeal-metastasis-from-solid-tumors-with-adverse-prognostic-factors-a-prospective-and-single-arm-study
#13
Zhenyu Pan, Guozi Yang, Hua He, Gang Zhao, Tingting Yuan, Yu Li, Weiyan Shi, Pengxiang Gao, Lihua Dong, Yunqian Li
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety of intrathecal chemotherapy (IC) combined with concomitant involved-field radiotherapy (IF-RT) for treating LM from solid tumors with adverse prognostic factors. Fifty-nine patients with LM from various solid tumors were enrolled between May 2010 and December 2014. Concurrent therapy consisted of concomitant IC (methotrexate 12...
October 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27162421/profile-of-malignant-spinal-cord-compression-one-year-study-at-regional-cancer-center
#14
Malik Tariq Rasool, Kaneez Fatima, Najmi Arshad Manzoor, Syed Arshad Mustafa, Lone Mohammad Maqbool, Wani Shaqul Qamar, Fir Afroz, Nazir Ahmad Khan, Saqib Ahmad Shah, Manan Shah
BACKGROUND AND OBJECTIVES: Malignant spinal cord compression is an oncologic emergency, unless diagnosed early and treated appropriately, can lead to permanent neurological impairment and compromised quality of life of patients. We analyzed the epidemiology and the effect of common interventions on the outcome in these patients. PATIENTS AND METHODS: We conducted a prospective study of 77 patients in the year 2014 and recorded relevant patient and disease characteristics...
April 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27094550/effects-of-src-kinase-inhibition-in-cancer-induced-bone-pain
#15
Milena De Felice, Daniel Lambert, Ingunn Holen, K Jane Escott, David Andrew
BACKGROUND: Bone metastases occur frequently in advanced breast, lung, and prostate cancer, with approximately 70% of patients affected. Pain is a major symptom of bone metastases, and current treatments may be inadequate or have unacceptable side effects. The mechanisms that drive cancer-induced bone pain are not fully understood; however, it is known that there is sensitization of both peripheral bone afferents and central spinal circuits. It is well established that the N-methyl-D-aspartate receptor plays a major role in the pathophysiology of pain hypersensitivity...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27033311/are-allogeneic-blood-transfusions-associated-with-decreased-survival-after-surgical-treatment-for-spinal-metastases
#16
Nuno Rui Paulino Pereira, Reinier B Beks, Stein J Janssen, Mitchel B Harris, Francis J Hornicek, Marco L Ferrone, Joseph H Schwab
BACKGROUND CONTEXT: Perioperative allogeneic blood transfusions have been associated with decreased survival after surgical resection of primary and metastatic cancer. Studies investigating this association for patients undergoing resection of bone metastases are scarce and controversial. PURPOSE: We assessed (1) whether exposure to perioperative allogeneic blood transfusions was associated with decreased survival after surgery for spinal metastases and (2) if there was a dose-response relationship per unit of blood transfused...
August 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26998160/effect-of-synchronous-solitary-bone-metastasectomy-and-lung-cancer-resection-on-non-small-cell-lung-cancer-patients
#17
Tiancheng Zhao, Zongli Gao, Weiming Wu, Weiwei He, Y I Yang
Lung cancer is the most frequent cause of cancer-associated mortality among men and women globally. The skeleton is one of the most common metastatic sites. The majority of patients exhibiting bone metastases are treated using systemic therapy or symptom-based palliative approaches without surgery. The present study attempted to improve the therapeutic effects of synchronous surgeries in resectable non-small cell lung cancer patients exhibiting solitary bone metastasis. A total of 5 patients underwent synchronous lung cancer resections and solitary bone metastasectomies between October 2009 and November 2011 in the Department of Cardiothoracic Surgery, Shanghai Sixth People's Hospital (Shanghai, China)...
March 2016: Oncology Letters
https://www.readbyqxmd.com/read/26980332/prediction-of-skeletal-related-events-in-patients-with-non-small-cell-lung-cancer
#18
Hisaki Aiba, Tomoki Kimura, Takaya Yamagami, Nobuyuki Watanabe, Hironari Sakurai, Hiroaki Kimura, Shingo Shimozaki, Satoshi Yamada, Takanobu Otsuka
PURPOSE: Advanced lung cancer frequently causes bone metastasis which can be associated with skeletal-related events (SREs) that may cause significant deterioration of the patient's quality of life (QoL). The Spinal Instability Neoplastic Score (SINS) can be used to assist in standardizing evaluations of neoplastic spinal instability between spinal and non-spine surgeons. This research investigated the association between SREs and SINS for patients with non-small cell lung cancer (NSCLC)...
August 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26935468/the-social-science-of-surgery-commentary-on-an-article-by-yu-tang-md-et-al-effect-of-surgery-on-quality-of-life-of-patients-with-spinal-metastasis-from-non-small-cell-lung-cancer
#19
COMMENT
Megan E Anderson
No abstract text is available yet for this article.
March 2, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/26935462/effect-of-surgery-on-quality-of-life-of-patients-with-spinal-metastasis-from-non-small-cell-lung-cancer
#20
Yu Tang, Jintao Qu, Juan Wu, Huan Liu, Tongwei Chu, Jianru Xiao, Yue Zhou
BACKGROUND: Recently, more clinicians have realized the importance of quality of life in the treatment decision-making process. The goal of this study was to determine whether surgery for patients with spinal metastases from non-small-cell lung cancer (NSCLC) could improve their quality of life and prolong survival. METHODS: The study included 133 patients who had been treated for NSCLC spinal metastases between 2010 and 2014. These patients were divided into two groups according to whether or not they had received spinal surgery...
March 2, 2016: Journal of Bone and Joint Surgery. American Volume
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