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Intravenous acetaminophen, CABG

Pia Holmér Pettersson, Jan Jakobsson, Anders Owall
OBJECTIVE: The purpose of this study was to evaluate if intravenous acetaminophen compared to oral administration reduced the consumption of opioids and their side effects without an increase in pain during the stay in the intensive care unit (ICU). DESIGN: Prospective, randomized study. SETTING: An ICU in a university hospital. PARTICIPANTS: Eighty patients with written informed consent undergoing coronary artery bypass grafting with cardiopulmonary bypass...
June 2005: Journal of Cardiothoracic and Vascular Anesthesia
Alan Sustić, Marko Zelić, Alen Protić, Zeljko Zupan, Ognjen Simić, Kristian Desa
AIM: To evaluate the effect of metoclopramide on gastric emptying in coronary artery bypass graft (CABG) surgery patients with early enteral nutrition and to evaluate the effect of metoclopramide on motility of the gallbladder in these patients. METHODS: A prospective, randomized, placebo-controlled, double-blind study of 40 patients treated at cardiosurgical intensive care unit after CABG surgery. The patients were divided into two groups: metoclopramide group (20 patients; age 60-/+9 years; 85% male), and control group (20 patients; age 59-/+8 years; 70% male)...
April 2005: Croatian Medical Journal
Elisabeth Ott, Nancy A Nussmeier, Peter C Duke, Robert O Feneck, R Peter Alston, Michael C Snabes, Richard C Hubbard, Ping H Hsu, Lawrence J Saidman, Dennis T Mangano, et al.
OBJECTIVE: Inhibition of cyclooxygenase 2 provides analgesia in ambulatory patients. We prospectively evaluated the safety and efficacy of a newly introduced cyclooxygenase 2 inhibitor in patients undergoing coronary artery bypass grafting surgery through a median sternotomy in a randomized clinical trial. METHODS: A total of 462 patients with New York Heart Association classes I to III who were less than 77 years of age and were from 58 institutions in the United States, Canada, Germany, and the United Kingdom participated in this multicenter, phase III, placebo-controlled, double-blind, randomized, parallel-group trial...
June 2003: Journal of Thoracic and Cardiovascular Surgery
Colin Royse, Alistair Royse, Paul Soeding, Duncan Blake, Jenny Pang
BACKGROUND: Postoperative pain may be severe after coronary artery bypass surgery. High thoracic epidural analgesia (HTEA) provides intense analgesia. METHODS: Eighty patients were randomized to HTEA or intravenous morphine analgesia (control). Patients received coronary artery bypass surgery (CABG) with cardiopulmonary bypass. Pain was measured by visual analogue scale 0 to 10. Psychologic morbidity, intraoperative hemodynamics, ventricular function, lung function, and physiotherapy cooperation were also assessed...
January 2003: Annals of Thoracic Surgery
N R Searle, M Roy, G Bergeron, J Perrault, J Roof, C Heermans, M Courtemanche, C Demers, R Cartier
We conducted a study to compare the effectiveness of patient-controlled analgesia (PCA) technique to conventional analgesic therapy (CAT) after coronary artery bypass graft (CABG). The PCA group received hydromorphone 0.1 basal infusion and bolus doses of 0.2 mg Q 5 min (maximum 1.2 while the CAT group received morphine 2.5 mg iv Q 30 min prn until extubation followed by prn meperidine 1 im Q 4 hr or acetaminophen 325 mg with codeine 30 mg po (1 or 2 tablets) when oral intake was possible...
March 1994: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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