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Phyllodes tumor

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https://www.readbyqxmd.com/read/28512246/tumor-associated-macrophages-promote-malignant-progression-of-breast-phyllodes-tumors-by-inducing-myofibroblast-differentiation
#1
Yan Nie, Jia-Ning Chen, Di Huang, Yandan Yao, Jiewen Chen, Lin Ding, Jiayi Zeng, Shicheng Su, Xue Chao, Fengxi Su, Herui Yao, Hai Hu, Erwei Song
Myofibroblast differentiation plays an important role in the malignant progression of phyllodes tumor (PT), a fast-growing neoplasm derived from periductal stromal cells of the breast. Macrophages are frequently found in close proximity with myofibroblasts, but it is uncertain whether they are involved in the myofibroblast differentiation during PT progression. Here we show that increased density of tumor associated macrophage (TAM) correlates with malignant progression of PT. We found that TAM stimulated myofibroblast differentiation and promoted the proliferation and invasion of PT cells...
May 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28472030/combination-of-shear-wave-elastography-and-color-doppler-feasible-method-to-avoid-unnecessary-breast-excision-of-fibroepithelial-lesions-diagnosed-by-core-needle-biopsy
#2
Ga Ram Kim, Ji Soo Choi, Boo-Kyung Han, Eun Young Ko, Eun Sook Ko, Soo Yeon Hahn
BACKGROUND: We evaluated shear-wave elastography (SWE) and color Doppler ultrasonography (US) features for fibroepithelial lesions (FELs), and to evaluate their utility to differentiate fibroadenomas (FAs) and phyllodes tumors (PTs). METHODS: This retrospective study included 67 FELs pathologically confirmed (49 FAs, 18 PTs). B-mode US, SWE and color Doppler US were performed for each lesion. Mean elasticity (Emean), maximum elasticity (Emax), and vascularity were determined by SWE and Doppler US...
2017: PloS One
https://www.readbyqxmd.com/read/28469344/synchronous-malignant-phyllodes-tumor-with-skin-ulceration-and-invasive-carcinoma-as-collision-tumor
#3
Rajeshwari K Muthusamy, Sangita S Mehta
Phyllodes tumor is a rare fibroepithelial biphasic tumor of the breast composed of hypercellular mesenchymal stroma and double-layered epithelial component, arranged in clefts with leaf-like projections. Phyllodes tumor with coincidental presence of invasive carcinoma or in situ ductal carcinoma in the same or distinct breast is a rare occurrence, documented by some reports. Invasive carcinoma can be seen within or outside the phyllodes tumor. Skin ulceration by malignant phyllodes tumor with coexisting invasive carcinoma as collision tumor is extremely rare...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28458828/giant-phyllodes-tumor-of-the-breast-with-diffuse-myxoid-changes-in-an-adolescent-girl-a-case-report
#4
Ji Young Lee
Giant phyllodes tumors (PT) are an uncommon fibroepithelial neoplasm and especially rare in adolescent girls. Diagnosis is difficult not only due to the rarity of PT, but also owing to the resemblance of its clinical and imaging features with fibroadenoma. The author reports a case of a giant PT in a 14-year-old girl. Clinical examination showed a large painful mass in the left breast, and an abscess was initially suspected. But magnetic resonance imaging (MRI) displayed features characteristic of PT. Following complete surgical excision of the mass, histopathology confirmed the diagnosis of a benign PT with diffuse myxoid changes, consistent with the MRI findings...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28413897/fibroadenoma-with-pleomorphic-stromal-giant-cells-it-s-not-as-bad-as-it-looks
#5
Jonathan Wawire, Kamaljeet Singh, Margaret M Steinhoff
Clinically relevant histological categorization of fibroepithelial lesions can be a daunting task, especially in a core needle biopsy. Assessment of stromal nuclear atypia, including nuclear pleomorphism and mitotic activity, is a key morphological feature employed to classify fibroepithelial lesions. We describe a case of fibroadenoma with markedly atypical nuclear features in the stromal cells that led to misclassification as phyllodes tumor in the core needle biopsy. Excision showed a fibroadenoma containing pleomorphic stromal giant cells, with occasional mitotic figures, including atypical forms...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28406095/a-giant-phyllodes-tumor-of-the-breast-causing-severe-disfigurement-a-case-report
#6
Gianluca Franceschini, Danilo Di Giorgio, Sabatino D'Archi, Alba Di Leone, Alejandro Martin Sanchez, Riccardo Masetti
Phyllodes tumours (PTs) are rare fibroepithelial neoplasms representing about 0,2% to 2% of all breast tumors with an incidence of about 2.1 per million. The classification proposed by the World Health Organization for PTs into benign, borderline, and malignant is based on a combination of several histologic features. High-grade malignant phyllodes tumors may spread by hematogenous route. While smaller and moderate size malignant phyllodes may typically be seen, gigantic ones with larger than 10 cm in diameter are very rare...
January 20, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28381138/phyllodes-tumor-with-heterologous-liposarcomatous-differentiation
#7
Magnus Hallin, Khin Thway
No abstract text is available yet for this article.
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28380418/expression-of-emt-markers-and-mode-of-surgery-are-prognostic-in-phyllodes-tumors-of-the-breast
#8
Xiaolong Feng, Lin Zhao, Honghong Shen, Xiaozhen Liu, Yang Yang, Shuhua Lv, Yun Niu
Phyllodes tumors of the breast are rare neoplasms that account for <1% of all mammary tumors and 2-3% of fibro-epithelial neoplasms of the breast. We evaluated the clinicopathological characteristics of a cohort of 246 Chinese patients in relation to the expression of epithelial-to-mesenchymal (EMT) markers in benign, borderline and malignant tumors and the prognostic value of different surgical regimens. We observed that survival outcomes correlated with the mode of surgical management in the three patient groups...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28370063/total-variation-based-dce-mri-decomposition-by-separating-lesion-from-background-for-time-intensity-curve-estimation
#9
Hui Liu, Yuanjie Zheng, Dong Liang, Pinpin Tang, Fuquan Ren, Lina Zhang, Zuowei Zhao
PURPOSE: This study aims to obtain the accurate time intensity curve (TIC) of a dynamic contrast-enhanced magnetic resonance image (DCE-MRI) by eliminating the normal tissue enhancement and obtaining pure lesion information. The TIC of DCE-MRI is sometimes distorted because of the influence of normal tissue. In this paper, a new tracer-kinetic modeling based on total variation (DC-TV) is proposed to address this problem by decomposing the DCE-MRI into the normal tissue image and the lesion image...
March 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28331755/phyllodes-tumor-of-the-breast-analysis-of-48-patients
#10
Murat Özgür Kılıç, Serdar Gökay Terzioğlu, Betül Bozkurt, Gül Dağlar
OBJECTIVE: Phyllodes tumor (PT) is a rare biphasic breast neoplasm that accounts for less than 1% of all breast tumors. The aim of this study was to evaluate the clinicopathologic features, diagnostic difficulties, and therapeutic outcomes of patients with PT. MATERIALS AND METHODS: A total of 48 female patients who underwent surgery for PT were included in the study. Patient characteristics, clinicopathologic features of tumors, diagnostic findings, surgical outcomes, adjuvant therapies, and follow-up findings were retrospectively evaluated...
October 2016: Journal of Breast Health (2013)
https://www.readbyqxmd.com/read/28327352/update-on-the-diagnosis-and-management-of-malignant-phyllodes-tumors-of-the-breast
#11
REVIEW
Matthew Strode, Thaer Khoury, Christopher Mangieri, Kazuaki Takabe
Malignant phyllodes tumors of the breast are a rare entity. They occur infrequently but most often in younger women in comparison to typical epithelial-based breast cancers. Treatment of these tumors is not without controversy and in this review we will present an update on the diagnosis and management of malignant phyllodes tumors of the breast.
March 16, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28299887/fibroepithelial-lesions-in-the-breast-of-adolescent-females-a-clinicopathological-study-of-54-cases
#12
Dara S Ross, Dilip D Giri, Muzaffar M Akram, Jeffrey P Catalano, Cristina Olcese, Kimberly J Van Zee, Edi Brogi
Fibroepithelial lesions (FELs) are the most frequent breast tumors in adolescent females. The pubertal hormonal surge could impact the growth and microscopic appearance of FELs in this age group. In this study, we evaluate the morphology and clinical behavior of FELs in adolescents. We searched the 1992-2012 pathology data base for FELs in females 18 years old or younger (F ≤18 years). Seven FELs from 1975 to 1983 were also included. Three pathologists reviewed all available material. Patient (pt) characteristics and follow-up information were obtained from electronic medical records...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28295007/-anogenital-mammary-like-glands-and-related-lesions-part-1-benign-tumors-and-tumor-like-disorders
#13
A M Konstantinova, I E Belousova, D Katserovska, M Mikhal, K V Shelekhova, D V Kazakov
Anogenital mammary-like glands represent a normal anatomic constituent of the anogenital area and may give rise to many benign and malignant tumors that morphologically mimic similar breast diseases. The literature review is complemented by a description of 286 cases of benign tumors and tumor-like processes in the mammary-like glands. The paper presents the clinical and morphological characteristics of papillary hidradenoma, fibroadenoma, benign phyllodes tumor, lactating adenoma, sclerosing adenosis, pseudoangiomatous stromal hyperplasia, etc...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28275427/resection-and-reconstruction-following-recurrent-malignant-phyllodes-case-report-and-review-of-literature
#14
Aashish Rajesh, Mohammed Farooq
INTRODUCTION: Phyllodes tumors are uncommon biphasic fibroepithelial neoplasms of the breast of varying malignant potential occurring in middle aged women. They exhibit diverse biological behavior. Margin free excision is the mainstay of treatment. CASE PRESENTATION: A 27 year-old lady was referred with a painless ulceroproliferative right breast lesion which had rapidly progressed over six months. Three years back, she had been diagnosed with a borderline phyllodes tumor and underwent a wide local excision followed by a right mastectomy for recurrence...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28267544/first-ultrasound-diagnosis-of-bi-rads-3-lesions-in-young-patients-can-6-months-follow-up-be-sufficient-to-assess-stability
#15
Magda Marcon, Thomas Frauenfelder, Anton S Becker, Konstantin J Dedes, Andreas Boss
OBJECTIVES: To evaluate the outcome of repeated short-term follow-up with ultrasound in no high-risk young patients with a BI-RADS3 lesion at first examination. METHODS: In this IRB-approved study 492 women, aged 18-34 years (mean±standard deviation, 28±4.5years) with first breast ultrasound examination in 2012-2014 were retrospectively evaluated. Inclusion criteria were: at least one BI-RADS3 lesion and (a) biopsy/surgical excision or (b) follow-up of at least 18 months (including a 6-month follow-up)...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28267263/genetic-analysis-of-uterine-adenosarcomas-and-phyllodes-tumors-of-the-breast
#16
Felipe C Geyer, Kathleen A Burke, Salvatore Piscuoglio, Charlotte K Y Ng, Anastasios D Papanastasiou, Caterina Marchiò, Pier Selenica, Marcia Edelweiss, Melissa P Murray, Edi Brogi, Robert A Soslow, Brian P Rubin, Larry Norton, Jorge S Reis-Filho, Britta Weigelt
Uterine adenosarcomas and breast phyllodes tumors (PTs) are morphologically similar, being composed of stromal projections in a leaf-like fashion lined by epithelial cells. Here, we investigated whether their histologic similarities would be mirrored at the genetic level. The previously reported repertoires of somatic genetic alterations found in 19 adenosarcomas and 22 PTs (six benign, six borderline, and 10 malignant) were compared. PTs significantly more frequently displayed mutations affecting MED12, the TERT gene promoter and bona fide cancer genes, whereas adenosarcomas harbored a higher rate of MDM2/CDK4 and TERT gene amplifications...
March 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28224691/phyllodes-tumor-in-the-vulva
#17
Alexandra Moulla, Lisa Hunt, Hizbullah Shaikh, Shreelata Datta
No abstract text is available yet for this article.
February 22, 2017: Breast Journal
https://www.readbyqxmd.com/read/28210881/comprehensive-genomic-profiling-of-malignant-phyllodes-tumors-of-the-breast
#18
Sahar Nozad, Christine E Sheehan, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Alexa B Schrock, Kim M Hirshfield, Nadia Ali, Shridar Ganesan, Siraj M Ali, Vincent A Miller, Philip J Stephens, Jeffrey S Ross, Jon H Chung
PURPOSE: Malignant phyllodes tumors (MPT) are exceptionally rare, and the genomic drivers of these tumors are still being elucidated. We performed comprehensive genomic profiling (CGP) of MPT to identify genomic alterations that will inform approaches to targeted therapy for patients with MPT, including relapsed, refractory, and metastatic disease. METHODS: DNA was extracted from formalin-fixed, paraffin-embedded samples from 24 consecutive patient cases of MPT...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28203559/fulminant-course-in-a-case-of-malignant-phyllodes-tumor
#19
Young Woo Chang, Hwan Soo Kim, Deok Woo Kim, Gil Soo Son
We present the case of a 31-year-old woman with an inflammatory and ulcerative malignant phyllodes tumor in her right breast. A right modified radical mastectomy and transverse rectus abdominis myocutaneous (TRAM) flap were performed. A month after the initial operation, several masses recurred at the superior margin and deep margin of the TRAM flap. Wide excision was performed, but masses recurred at the inferior margin and in both lung fields 2 weeks after the second operation. Six weeks after the second operation, the patient died due to progression of dyspnea and respiratory failure...
February 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28203179/malignant-phyllodes-tumor-presenting-in-bone-brain-lungs-and-lymph-nodes
#20
Eric D Johnson, Evin Gulbahce, Joseph McNally, Saundra S Buys
INTRODUCTION: Phyllodes tumors (PTs) are rare fibroepithelial tumors of the breast which are classified as benign, borderline, or malignant. Malignant PTs account for <1% of malignant breast tumors, and borderline tumors have potential to progress to malignant tumors. Metastatic recurrences are most commonly documented in bone and lungs. We report an extremely rare presentation of recurrent malignant PTs involving the brain, lung, lymph nodes, and bone. CASE: A 66-year-old female presented with a large breast mass...
September 2016: Case Reports in Oncology
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