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https://www.readbyqxmd.com/read/28655173/feasibility-efficacy-and-cost-analysis-of-promoting-smoking-cessation-at-outdoor-smoking-hotspots-a-pre-post-study
#1
Yee Tak Derek Cheung, Tai Hing Lam, William Ho Cheung Li, Man Ping Wang, Sophia Siu Chee Chan
Introduction: To motivate smokers to quit, there is a need for enhanced smoking cessation (SC) recruitment and for innovative and proactive approaches to SC. This study evaluated the feasibility, efficacy and cost of promoting SC in public outdoor areas where smokers gather to smoke (smoking hotspots). Methods: We selected 14 smoking hotspots in Hong Kong for SC promotion in 2015. University students were trained as SC ambassadors to deliver brief SC intervention, and to recruit smokers for telephone follow-up...
June 24, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28655135/home-based-exercise-program-improves-balance-and-fear-of-falling-in-community-dwelling-older-adults-with-mild-alzheimer-s-disease-a-pilot-study
#2
Kalpana P Padala, Prasad R Padala, Shelly Y Lensing, Richard A Dennis, Melinda M Bopp, Paula K Roberson, Dennis H Sullivan
BACKGROUND/OBJECTIVE: Balance problems are common in older adults with Alzheimer's disease (AD). The objective was to study the effects of a Wii-Fit interactive video-game-led physical exercise program to a walking program on measures of balance in older adults with mild AD. METHODS: A prospective randomized controlled parallel-group trial (Wii-Fit versus walking) was conducted in thirty community-dwelling older adults (73±6.2 years) with mild AD. Home-based exercises were performed under caregiver supervision for 8 weeks...
June 22, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28655093/-long-term-follow-up-of-multiple-myeloma-after-autologous-hematopoietic-stem-cell-transplantation-a-single-center-results
#3
W W Sui, D H Zou, G An, S H Yi, S H Deng, W Y Huang, T Y Wang, J Li, H Liu, M W Fu, R Lyu, W Liu, Y Xu, Z J Li, Y Z Zhao, L G Qiu
Objective: To evaluate the efficacy and long-term outcome of a combined protocol for multiple myeloma (MM) , including induction therapy, autologous hematopoietic stem cell transplantation (ASCT) and consolidation and maintenance therapy. Methods: Clinical records of 144 patients with MM from January 1, 2005 to February 1, 2016 were retrospectively analyzed. Results: The overall response rate (ORR) after ASCT was 100.0%, in which the complete remission (CR) was 64.1% and the best treatment response rate of superior to PR was 89...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28655075/-surgical-treatment-of-colorectal-liver-metastases
#4
J M Xu, D X Zhu, L Ren
Surgical resection of the metastases offers the only opportunity for long-term survival in colorectal liver metastases. However, only 10% to 20% of patients present with resectable disease, and so how to increase surgical patients has been a clinical hotspot. In addition to expanding surgical indications, two-stage hepatectomy and convertible therapy are optional. In convertible therapy, initial treatment regimen decides long-term benefit, and it is important to select appropriate patient population in addition to Ras status when anti-epithelial growth factor receptor monoclonal antibody is used...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28655021/the-diagnosis-and-treatment-of-prostate-cancer-a-review
#5
Mark S Litwin, Hung-Jui Tan
Importance: Prostate cancer is the most common cancer diagnosis made in men with more than 160 000 new cases each year in the United States. Although it often has an indolent course, prostate cancer remains the third-leading cause of cancer death in men. Observations: When prostate cancer is suspected, tissue biopsy remains the standard of care for diagnosis. However, the identification and characterization of the disease have become increasingly precise through improved risk stratification and advances in magnetic resonance and functional imaging, as well as from the emergence of biomarkers...
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28655016/effect-of-electroacupuncture-on-urinary-leakage-among-women-with-stress-urinary-incontinence-a-randomized-clinical-trial
#6
Zhishun Liu, Yan Liu, Huanfang Xu, Liyun He, Yuelai Chen, Lixin Fu, Ning Li, Yonghui Lu, Tongsheng Su, Jianhua Sun, Jie Wang, Zenghui Yue, Wei Zhang, Jiping Zhao, Zhongyu Zhou, Jiani Wu, Kehua Zhou, Yanke Ai, Jing Zhou, Ran Pang, Yang Wang, Zongshi Qin, Shiyan Yan, Hongjiao Li, Lin Luo, Baoyan Liu
Importance: Electroacupuncture involving the lumbosacral region may be effective for women with stress urinary incontinence (SUI), but evidence is limited. Objective: To assess the effect of electroacupuncture vs sham electroacupuncture for women with SUI. Design, Setting, and Participants: Multicenter, randomized clinical trial conducted at 12 hospitals in China and enrolling 504 women with SUI between October 2013 and May 2015, with data collection completed in December 2015...
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28654920/greater-real-life-diagnostic-efficacy-of-allergen-molecule-based-diagnosis-for-prescription-of-immunotherapy-in-an-area-with-multiple-pollen-exposure
#7
Ulbosin Saltabayeva, Viktoriya Garib, Marina Morenko, Rafail Rosenson, Zhanat Ispayeva, Madina Gatauova, Loreta Zulus, Aleksandr Karaulov, Felix Gastager, Rudolf Valenta
BACKGROUND: Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing for the identification of the disease-causing allergen sources. The study was conducted in an area where patients are exposed to pollen from multiple sources (trees, grasses, and weeds) at the same time to compare the diagnostic efficiency of the 2 forms of diagnosis...
June 28, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28654771/trajectories-of-social-anxiety-cognitive-reappraisal-and-mindfulness-during-an-rct-of-cbgt-versus-mbsr-for-social-anxiety-disorder
#8
Philippe R Goldin, Amanda S Morrison, Hooria Jazaieri, Richard G Heimberg, James J Gross
Cognitive-Behavioral Group Therapy (CBGT) and Mindfulness-Based Stress Reduction (MBSR) are efficacious in treating social anxiety disorder (SAD). It is not yet clear, however, whether they share similar trajectories of change and underlying mechanisms in the context of SAD. This randomized controlled study of 108 unmedicated adults with generalized SAD investigated the impact of CBGT vs. MBSR on trajectories of social anxiety, cognitive reappraisal, and mindfulness during 12 weeks of treatment. CBGT and MBSR produced similar trajectories showing decreases in social anxiety and increases in reappraisal (changing the way of thinking) and mindfulness (mindful attitude)...
June 3, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28654684/intravenous-immunoglobulin-therapy-in-kidney-transplant-recipients-with-de-novo-dsa-results-of-an-observational-study
#9
Marie Matignon, Caroline Pilon, Morgane Commereuc, Cynthia Grondin, Claire Leibler, Tomek Kofman, Vincent Audard, José Cohen, Florence Canoui-Poitrine, Philippe Grimbert
BACKGROUND: Approximately 25% of kidney transplant recipients develop de novo anti-HLA donor-specific antibodies (dnDSA) leading to acute antibody-mediated rejection (ABMR) in 30% of patients. Preemptive therapeutic strategies are not available. METHODS: We conducted a prospective observational study including 11 kidney transplant recipients. Inclusion criteria were dnDSA occurring within the first year after transplant and normal allograft biopsy. All patients were treated with high-dose IVIG (2 g/kg 0, 1 and 2 months post-dnDSA)...
2017: PloS One
https://www.readbyqxmd.com/read/28654672/cost-effectiveness-analysis-of-oral-fentanyl-formulations-for-breakthrough-cancer-pain-treatment
#10
Paolo Angelo Cortesi, Lucia Sara D'Angiolella, Renato Vellucci, Massimo Allegri, Giuseppe Casale, Carlo Favaretti, Flavia Kheiraoui, Giancarlo Cesana, Lorenzo Giovanni Mantovani
Breakthrough cancer Pain (BTcP) has a high prevalence in cancer population. Patients with BTcP reported relevant health care costs and poor quality of life. The study assessed the cost-effectiveness of the available Oral Fentanyl Formulations (OFFs) for BTcP in Italy. A decision-analytical model was developed to estimate costs and benefits associated with treatments, from the Italian NHS perspective. Expected reductions in pain intensity per BTcP episodes were translated into, percentage of BTcP reduction, resource use and Quality-Adjusted-Life-Years (QALYs)...
2017: PloS One
https://www.readbyqxmd.com/read/28654669/role-of-magnesium-supplementation-in-the-treatment-of-depression-a-randomized-clinical-trial
#11
Emily K Tarleton, Benjamin Littenberg, Charles D MacLean, Amanda G Kennedy, Christopher Daley
Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An open-label, blocked, randomized, cross-over trial was carried out in outpatient primary care clinics on 126 adults (mean age 52; 38% male) diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5-19...
2017: PloS One
https://www.readbyqxmd.com/read/28654594/comparison-of-steroid-and-botulinum-toxin-type-a-monotherapy-with-combination-therapy-for-treating-human-hypertrophic-scars-in-an-animal-model
#12
Hung-Chang Chen, Cheng-I Yen, Shih-Yi Yang, Cheng-Jen Chang, Jui-Yung Yang, Shu-Yin Chang, Shiow-Shuh Chuang, Yen-Chang Hsiao
BACKGROUND: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. METHODS: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided into four groups: negative control (group A), triamcinolone alone (group B), Botox alone (group C), and a combination of triamcinolone and Botox (group D)...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654586/botulinum-toxin-for-neck-rejuvenation-assessing-efficacy-and-redefining-patient-selection
#13
Samer F Jabbour, Elio G Kechichian, Cyril J Awaida, Roland R Tomb, Marwan W Nasr
BACKGROUND: The "Nefertiti lift" consists of injecting the platysmal bands and the inferior border of the mandible with botulinum toxin. No clinical trial has evaluated its effect on the different lower face and neck aging components, and little is known about the clinical characteristics that predict treatment success. METHODS: Patients were injected with abobotulinumtoxinA along the inferior border of the mandible and into the platysmal bands. Using standardized preinjection and postinjection photographs, the jowls, marionette lines, oral commissures, neck volume, and platysmal bands at maximal contraction and at rest were assessed with validated photonumeric scales...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654576/effect-of-postoperative-dressing-on-excisions-performed-on-the-leg-a-comparison-between-zinc-oxide-compression-dressing-versus-standard-wound-care
#14
Carol B Thompson, Timothy L Wiemken, Timothy S Brown
BACKGROUND: Wound healing on the legs may be complicated by delayed healing and other postoperative problems. Two potential postoperative wound care regimens for sutured excisions on the legs include a standard pressure dressing and zinc oxide compression dressing. Limited data exist comparing the efficacy of these 2 options. OBJECTIVE: To compare outcomes of standard postoperative wound care dressing versus postoperative use of a zinc oxide compression dressing for sutured repairs on the legs...
June 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28654558/the-efficacy-of-ultrasound-guided-type-ii-pectoral-nerve-blocks-in-perioperative-pain-management-for-immediate-reconstruction-after-modified-radical-mastectomy-a-prospective-randomized-study
#15
Kaiyuan Wang, Xiaobei Zhang, Tingting Zhang, Hui Yue, Shan Sun, Hongwei Zhao, Peng Zhou
OBJECTIVES: The pectoral nerves (Pecs) II block is a technique that places local anesthetic between the thoracic muscles to block the axillary and breast regions. This study aimed to compare the quality of perioperative analgesia and side effects of the Pecs II block under general anesthesia versus general anesthesia alone in immediate unilateral breast reconstruction with an implant and latissimus dorsi (LD) flap after modified radical mastectomy. METHODS: Sixty-four patients scheduled for immediate breast reconstruction after modified radical mastectomy were randomly allocated into the Pecs II block under general anesthesia group (Group P, n=32) or the general anesthesia alone group (Group G, n=32)...
June 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28654557/the-effectiveness-of-transcranial-direct-current-stimulation-as-an-add-on-modality-to-graded-motor-imagery-for-treatment-of-complex-regional-pain-syndrome-a-randomized-proof-of-concept-study
#16
Émilie Lagueux, Michaël Bernier, Patricia Bourgault, Kevin Whittingstall, Catherine Mercier, Guillaume Léonard, Sarah Laroche, Yannick Tousignant-Laflamme
BACKGROUND: The efficacy of graded motor imagery (GMI) for the management of complex regional pain syndrome (CRPS) is supported by evidence, but its treatment effect remains generally modest. Transcranial direct current stimulation (tDCS) has been advocated as an adjunct intervention to enhance the effect of motor imagery approaches in pain populations. OBJECTIVE: The purpose of this study was to investigate the effectiveness of GMI+active tDCS compared to the GMI+sham tDCS in the treatment of CRPS type I...
June 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28654365/treatment-efficacy-adherence-and-quality-of-life-among-women-younger-than-35-years-in-the-international-breast-cancer-study-group-text-and-soft-adjuvant-endocrine-therapy-trials
#17
Poornima Saha, Meredith M Regan, Olivia Pagani, Prudence A Francis, Barbara A Walley, Karin Ribi, Jürg Bernhard, Weixiu Luo, Henry L Gómez, Harold J Burstein, Vani Parmar, Roberto Torres, Josephine Stewart, Meritxell Bellet, Antonia Perelló, Faysal Dane, Antonio Moreira, Daniel Vorobiof, Michelle Nottage, Karen N Price, Alan S Coates, Aron Goldhirsch, Richard D Gelber, Marco Colleoni, Gini F Fleming
Purpose To describe benefits and toxicities of adjuvant endocrine therapies in women younger than 35 years with breast cancer (n = 582) enrolled in the Suppression of Ovarian Function Trial (SOFT) and Tamoxifen and Exemestane Trial (TEXT). Methods In SOFT, women still premenopausal after surgery with or without chemotherapy were randomly assigned to tamoxifen alone, tamoxifen plus ovarian function suppression (OFS), or exemestane plus OFS. In TEXT, all received OFS with or without concomitant chemotherapy and were randomly assigned to exemestane plus OFS or tamoxifen plus OFS...
June 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28654336/focal-therapy-for-prostate-cancer-with-in-bore-mr-guided-focused-ultrasound-two-year-follow-up-of-a-phase-i-trial-complications-and-functional-outcomes
#18
Kae Jack Tay, Christopher W S Cheng, Weber K O Lau, James Khoo, Choon Hua Thng, Jin Wei Kwek
Purpose To report the safety profile and 2-year functional outcomes of in-bore magnetic resonance (MR)-guided focused ultrasound on single cancer foci in men with prostate cancer. Materials and Methods Ethics approval was obtained from the centralized institutional review board for this prospective single-arm study, and patients provided informed consent. Patients with untreated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index tumor ≤10 mm(3)) underwent MR-guided focused ultrasound between July 2011 and February 2013...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28654304/a-prospective-randomized-double-blind-multicenter-study-comparing-continuous-diffusion-of-oxygen-therapy-to-sham-therapy-in-the-treatment-of-diabetic-foot-ulcers
#19
Mark Q Niederauer, Joel E Michalek, David G Armstrong
BACKGROUND: Over the past generation, preclinical data have suggested that there is a potential physiologic benefit to applying oxygen topically to wounds. However, we are unaware of any studies in the literature that have robustly assessed whether this would lead to a higher proportion of healing in similarly treated people without oxygen. Therefore, the purpose of this study was to assess this in people being treated for chronic diabetic foot ulcers (DFUs). METHODS: We enrolled and randomized 100 subjects with DFUs (79% male, aged 58...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28654297/eriodictyol-not-its-glucuronide-metabolites-attenuates-acetaminophen-induced-hepatotoxicity
#20
Ling Ye, Zhaoyu Wang, Yao Lan, Minghao Chen, Cailing Wen, Yanxian Hu, Zhong Qiu Liu
Acetaminophen (APAP) is one of the most commonly used oral analgesics and antipyretics, but hepatotoxicity including liver failure may occur after overdose. The therapeutic options for treating APAP hepatotoxicity are limited. Eriodictyol, a dietary flavonoid with anti-inflammatory and antioxidant properties, was used here to determine its protective effects against APAP-induced hepatotoxicity in mice. Various administration routes and pharmacokinetics-pharmacodynamics (PK-PD) analyses were used to determine these effects...
June 27, 2017: Molecular Pharmaceutics
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