keyword
MENU ▼
Read by QxMD icon Read
search

Comparative efficacy

keyword
https://www.readbyqxmd.com/read/29909584/comparison-of-clinical-results-between-novel-percutaneous-pedicle-screw-and-traditional-open-pedicle-screw-fixation-for-thoracolumbar-fractures-without-neurological-deficit
#1
Ming Yang, Qinpeng Zhao, Dingjun Hao, Zhen Chang, Shichang Liu, Xinhua Yin
OBJECTIVES: To compare the efficacy and safety of novel percutaneous minimally invasive pedicle screw fixation and traditional open surgery for thoracolumbar fractures without neurological deficit. METHODS: Sixty adult patients with single thoracolumbar fracture between June 2014 and June 2016 were recruited in this study, randomly divided into open fixation group (group A) or minimally invasive percutaneous fixation group (group B). Clinical and surgical evaluation including surgery time, blood losses, radiation times, hospital stay, and complication were performed...
June 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29909564/organized-screening-detects-breast-cancer-at-earlier-stage-regardless-of-molecular-phenotype
#2
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29909512/the-effectiveness-of-endoscopic-gastroplasty-for-obesity-treatment-according-to-fda-thresholds-systematic-review-and-meta-analysis-based-on-randomized-controlled-trials
#3
REVIEW
Antonio Coutinho Madruga-Neto, Wanderley Marques Bernardo, Diogo Turiani Hourneaux de Moura, Vitor Ottoboni Brunaldi, Rafael Krieger Martins, Iatagan Rocha Josino, Eduardo Turiani Hourneaux de Moura, Thiago Ferreira de Souza, Marco Aurélio Santo, Eduardo Guimarães Hourneaux de Moura
Endoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909357/abdominal-muscle-recruitment-and-its-effect-on-the-activity-level-of-the-hip-and-posterior-thigh-muscles-during-therapeutic-exercises-of-the-hip-joint
#4
Sharon M H Tsang, Amanda H M Lam, Melody H L Ng, Kiki W K Ng, Cherry O H Tsui, Benjamin Yiu
Abdominal exercise has been advocated to improve the protection of the spine and neuromuscular efficiency of the limb movements. The purpose of this study was to examine the effect of enhanced contraction of internal oblique and transversus abdominis (IO/TrA) on the activity level of the hip and posterior thigh muscles during therapeutic hip exercises. Twenty healthy females were required to perform eight hip exercises under two conditions, natural versus enhanced IO/TrA contraction conditions. Muscle activity of gluteus maximus, gluteus medius, tensor fasciae latae and biceps femoris of the exercising leg was measured by surface electromyography during hip exercises, and expressed in percentage normalized to the maximal voluntary isometric contraction (%MVIC)...
June 12, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29909285/efficacy-of-dexamethasone-in-preventing-acute-mountain-sickness-in-copd-patients-randomized-trial
#5
Michael Furian, Mona Lichtblau, Sayaka S Aeschbacher, Bermet Estebesova, Berik Emilov, Ulan Sheraliev, Nuriddin H Marazhapov, Maamed Mademilov, Batyr Osmonov, Maya Bisang, Stefanie Ulrich, Tsogyal D Latshang, Silvia Ulrich, Talant M Sooronbaev, Konrad E Bloch
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) may experience acute mountain sickness (AMS) and other altitude-related adverse health effects (ARAHE) when travelling to high altitude. We evaluated whether dexamethasone, a drug used for AMS prevention in healthy individuals, would prevent AMS/ARAHE in COPD. METHODS: In this placebo-controlled, double-blind, parallel-design trial COPD patients, GOLD grade 1-2, living below 800m, were randomized to receive dexamethasone (8mg/day) or placebo starting on the day before ascent and while staying in a high altitude clinic at 3100m for 2 days...
June 14, 2018: Chest
https://www.readbyqxmd.com/read/29909264/tamoxifen-versus-clomiphene-citrate-for-ovulation-induction-in-infertile-women
#6
REVIEW
Li Jie, Deng Li, Chen Yang, Zhang Haiying
This systematic review aimed to compare the clinical efficacy of tamoxifen with that of clomiphene citrate (CC) in anovulatory patients. The PubMed, EMBASE, and CNKI databases were searched up to October 2016 for literature comparing tamoxifen with CC in anovulatory women. The pooled risk ratios (RR) or standardized mean differences (SMD) with 95% confidence intervals (CIs) were subjected to statistical analysis. Twelve studies involving 1302 patients with 2030 ovulation-induction cycles were summarized. There were no statistically significant differences for the ovulation and pregnancy rates in the tamoxifen comparing to the CC group in the pooled analysis...
June 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909253/long-term-safety-and-efficacy-of-single-port-pars-plana-anterior-vitrectomy-with-limbal-infusion-during-anterior-segment-surgery
#7
Ivey L Thornton, Brian K McMains, Michael E Snyder
PURPOSE: To report the safety and efficacy of single-port pars plana anterior vitrectomy. SETTING: Cincinnati Eye Institute, Cincinnati, Ohio, USA. DESIGN: Retrospective case series. METHODS: Eyes that had anterior vitrectomy from September 2010 to June 2016 were electronically identified. Charts were reviewed for demographics, history of ocular trauma, underlying ocular or systemic comorbidity, surgical indications, outcomes, and postoperative complications...
June 13, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#8
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909135/evaluation-of-carbopol-as-an-adjuvant-on-the-effectiveness-of-progressive-atrophic-rhinitis-vaccine
#9
Jiansong Zhang, Meifen Wang, Nini Zhou, Yijuan Shen, Yufeng Li
The Gram-negative pathogen toxigenic P. multocida causes progressive atrophic rhinitis (PAR) in swine throughout the world. Although some vaccines are being developed against PAR, their efficacy has not been evaluated using carbopol. In our study, a mixture of killed B. bronchiseptica and P. multocida bacteria, combined with recombinant proteins containing the C- and N-termini of PMT, was emulsified using two different adjuvants (ISA-15A and carbopol 971). The efficacy of these two vaccines was evaluated in a mouse model...
June 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29909074/catheter-based-closure-of-the-patent-ductus-arteriosus-in-lower-weight-infants
#10
REVIEW
Leeann R Pavlek, Jonathan L Slaughter, Darren P Berman, Carl H Backes
Risks associated with drug therapy and surgical ligation have led health care providers to consider alternative strategies for patent ductus arteriosus (PDA) closure. Catheter-based PDA closure is the procedure of choice for ductal closure in adults, children, and infants ≥6kg. Given evidence among older counterparts, interest in catheter-based closure of the PDA in lower weight (<6kg) infants is growing. Among these smaller infants, the goals of this review are to: (1) provide an overview of the procedure; (2) review the types of PDA closure devices; (3) review the technical success (feasibility); (4) review the risks (safety profile); (5) discuss the quality of evidence on procedural efficacy; (6) consider areas for future research...
June 13, 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29909057/study-design-and-protocol-for-a-culturally-adapted-cognitive-behavioral-stress-and-self-management-intervention-for-localized-prostate-cancer-the-encuentros-de-salud-study
#11
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29909037/biosynthesis-molecular-modeling-and-statistical-optimization-of-xylanase-from-a-mangrove-associated-actinobacterium-streptomyces-variabilis-mab3-using-box-behnken-design-with-its-bioconversion-efficacy
#12
Muthusamy Sanjivkumar, Tamilselvan Silambarasan, Ramasamy Balagurunathan, Grasian Immanuel
The present study was undertaken to evaluate the biosynthesis, molecular modeling and statistical optimization of xylanase production through Box-Behnken design by a mangrove associated actinobacterium Streptomyces variabilis (MAB3). Initially, the production of xylanase by the selected strain was carried through submerged fermentation using birchwood xylan as substrate. Further the xylanase production was statistically optimized through Box-Behnken design. It showed 5.30 fold increase of xylanase production by the isolate compared to 'one factor at a time approach' in the presence of the basal medium containing birchwood xylan (2...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29909019/efficacy-of-ustekinumab-in-inducing-endoscopic-healing-in-patients-with-crohn-s-disease
#13
Paul Rutgeerts, Christopher Gasink, Daphne Chan, Yinghua Lang, Paul Pollack, Jean-Frederic Colombel, Douglas C Wolf, Douglas Jacobstein, Jewel Johanns, Philippe Szapary, Omoniyi J Adedokun, Brian G Feagan, William J Sandborn
BACKGROUND & AIMS: We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn's disease (CD). METHODS: We performed an endoscopy sub-study of 334 patients with moderate to severe CD participating in 3 randomized, controlled, phase 3 studies to determine the safety and efficacy of ustekinumab induction and maintenance therapy. All patients underwent colonoscopy at baseline and week 8 of the induction studies and at week 44 of the maintenance study; all colonoscopies were assessed by a blinded central reader...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29908939/delivery-system-for-budesonide-based-on-lipid-dna
#14
Yun Liu, I Sophie T Bos, Tjitske A Oenema, Herman Meurs, Harm Maarsingh, Anna K H Hirsch
Budesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize its drug efficacy and reduce adverse effects. In this work, we report the use of lipid-DNA (UU11mer), featuring two hydrophobic alkyl chains and forming micelles at a comparatively low critical micelle concentration, to render budesonide water-soluble with a high loading capacity (LC)...
June 14, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908933/diminished-kinesthetic-and-visual-motor-imagery-ability-in-adults-with-chronic-low-back-pain
#15
Roy La Touche, Mónica Grande-Alonso, Ferran Cuenca-Martínez, Luis Gónzalez-Ferrero, Luis Suso-Martí, Alba Paris-Alemany
BACKGROUND: Low back pain (LBP) is the most prevalent musculoskeletal problem among adults. It has been observed that patients with chronic pain have maladaptive neuroplastic changes and difficulty in imagination processes. OBJECTIVE: To assess the ability of patients with chronic LBP (CLBP) to generate kinesthetic and visual motor images and the time they spent on this mental task compared with asymptomatic participants. DESIGN: Prospective, A cross-sectional study...
June 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29908917/potential-effectiveness-of-long-acting-injectable-pre-exposure-prophylaxis-for-hiv-prevention-in-men-who-have-sex-with-men-a-modelling-study
#16
Brandon D L Marshall, William C Goedel, Maximilian R F King, Alyson Singleton, David P Durham, Philip A Chan, Jeffrey P Townsend, Alison P Galvani
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) prevents HIV infection in men who have sex with men (MSM); however, adherence is an ongoing concern. Long-acting injectable PrEP is being tested in phase 3 trials and could address challenges associated with adherence. We examined the potential effectiveness of long-acting injectable PrEP compared with oral PrEP in MSM. METHODS: We used an agent-based model to simulate HIV transmission in a dynamic network of 11 245 MSM in Atlanta, GA, USA...
June 13, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29908904/application-of-composite-dissolving-microneedles-with-high-drug-loading-ratio-for-rapid-local-anesthesia
#17
Haohui Zhan, Fengsen Ma, Yingcong Huang, Jie Zhang, Xiayun Jiang, Yongchang Qian
We report a type of dissolving microneedles (DMNs) which was made of composite matrix materials of hydroxypropyl methyl cellulose (HPMC) and poly(methylvinylether‑co‑maleic anhydride) (PMVE/MA copolymer, Gantrez S-97), and was successfully loaded with lidocaine hydrochloride. The weight of lidocaine hydrochloride loaded in the microneedles tip was 70% of the weight of the whole tip. The content was 3.43 ± 0.12 mg in weight, which was determined by high performance liquid chromatography (HPLC). The results for mechanical test showed that these microneedles were able to penetrate into the skin of the experimental animals, that was proved using organic staining, texture analyzer and histological examination...
June 14, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29908893/post-pegylated-and-crosslinked-polymeric-ssrna-nanocomplexes-as-adjuvants-targeting-lymph-nodes-with-increased-cytolytic-t-cell-inducing-properties
#18
Bo Lou, Ans De Beuckelaer, George R Dakwar, Katrien Remaut, Johan Grooten, Kevin Braeckmans, Bruno G De Geest, Enrico Mastrobattista, Stefaan De Koker, Wim E Hennink
Potent adjuvants are highly demanded for most protein and peptides based vaccine candidates in clinical development. Recognition of viral single stranded (ss)RNA by innate toll-like receptors 7/8 in dendritic cells results in a cytokine environment supportive to the establishment of long lasting antibody responses and Th1 oriented T cell immunity. To fully exploit the immunestimulatory properties of ssRNA, it needs to be adequately formulated to ensure its optimal delivery to dendritic cells in the vaccine draining lymph nodes...
June 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29908826/intramyocardial-autologous-cd34-cell-therapy-for-refractory-angina-a-meta-analysis-of-randomized-controlled-trials
#19
Poonam Velagapudi, Mohit Turagam, Dhaval Kolte, Sahil Khera, Omar Hyder, Paul Gordon, Herbert D Aronow, Jane Leopold, J Dawn Abbott
BACKGROUND: Previous studies have demonstrated that intramyocardial human CD34+ cells may relieve symptoms and improve clinical outcomes in chronic refractory angina unresponsive to optimal medical therapy or not amenable to revascularization. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of human CD34+ cells compared with placebo in chronic refractory angina. Primary efficacy outcomes in our analysis were angina frequency and exercise time...
June 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29908805/field-trial-to-evaluate-the-effect-of-an-intranasal-respiratory-vaccine-protocol-on-calf-health-ultrasonographic-lung-consolidation-and-growth-in-holstein-dairy-calves
#20
T L Ollivett, K E Leslie, T F Duffield, D V Nydam, J Hewson, J Caswell, P Dunn, D F Kelton
The objective of this field trial was to evaluate the effect of a vaccine protocol using a commercially available trivalent vaccine designed for intranasal use. Experimental challenge studies have demonstrated varying efficacies of vaccines administered via the intranasal route. A total of 468 calves from 3 herds were enrolled and randomized into 3 treatment groups (positive control, PC, n = 211; intranasal vaccine, IN, n = 215; negative control, NC, n = 42) and followed for 8 to 12 wk. The PC consisted of one dose of commercially available multivalent injectable vaccine against bovine respiratory syncytial virus, infectious bovine rhinotracheitis, parainfluenza 3, and bovine viral diarrhea administered subcutaneously at 6 wk of age...
June 13, 2018: Journal of Dairy Science
keyword
keyword
6190
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"