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Lymph node transfer

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https://www.readbyqxmd.com/read/28219835/marked-in-vivo-donor-treg-expansion-via-il-2-and-tl1a-ig-stimulation-ameliorates-gvhd-but-preserves-gvl-in-recipients-post-hsct
#1
Dietlinde Wolf, Henry Barreras, Cameron S Bader, Sabrina Copsel, Casey O Lightbourn, Brent J Pfeiffer, Norman H Altman, Eckhard R Podack, Krishna V Komanduri, Robert B Levy
Regulatory T cells (Tregs) are critical for self-tolerance. While adoptive transfer of expanded Tregs limits graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), ex vivo generation of large numbers of functional Tregs remains difficult. Here, we demonstrate that in vivo targeting of the TNF superfamily receptor TNFRSF25 using the TL1A-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice, which peaked within days and was nontoxic. Tregs increased in multiple compartments, including blood, lymph nodes, spleen and colon (a GVHD target tissue)...
February 17, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28194356/recurrent-advanced-lower-extremity-lymphedema-following-initial-successful-vascularized-lymph-node-transfer-a-clinical-and-histopathological-analysis
#2
Pedro Ciudad, Shivprasad Date, Oscar J Manrique, Wei-Ling Chang, Tsung-Chun Huang, Tsung-Wei Chen, Fabio Nicoli, Michelle Maruccia, Hung-Chi Chen
No abstract text is available yet for this article.
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28154564/immunization-of-newborn-mice-accelerates-the-architectural-maturation-of-lymph-nodes-but-aid-dependent-igg-responses-are-still-delayed-compared-to-the-adult
#3
Rosario Munguía-Fuentes, Juan Carlos Yam-Puc, Aarón Silva-Sánchez, Edith Marcial-Juárez, Isis Amara Gallegos-Hernández, Juana Calderón-Amador, Troy D Randall, Leopoldo Flores-Romo
Lymph nodes (LNs) have evolved to maximize antigen (Ag) collection and presentation as well as lymphocyte proliferation and differentiation-processes that are spatially regulated by stromal cell subsets, including fibroblastic reticular cells (FRCs) and follicular dendritic cells (FDCs). Here, we showed that naïve neonatal mice have poorly organized LNs with few B and T cells and undetectable FDCs, whereas adult LNs have numerous B cells and large FDC networks. Interestingly, immunization on the day of birth accelerated B cell accumulation and T cell recruitment into follicles as well as FDC maturation and FRC organization in neonatal LNs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28148784/different-expression-of-interferon-stimulated-genes-in-response-to-hiv-1-infection-in-dendritic-cells-according-to-their-maturation-state
#4
Esther Calonge, Mercedes Bermejo, Francisco Diez-Fuertes, Isabelle Mangeot, Nuria Gonzalez, Mayte Coiras, Laura Jimenez Tormo, Javier García-Perez, Nathalie Dereuddre-Bosquet, Roger Le Grand, José Alcamí
: Dendritic cells (DCs) are professional antigen presenting cells whose functions are dependent on their degree of differentiation. In their immature state, DCs, capture pathogens and migrate to the lymph nodes. During this process DCs become resident mature cells specialized in antigen presentation. DCs are characterized by a highly limiting environment to HIV-1 replication due to the expression of restriction factors as SAMHD1 and APOBEC3G. However, uninfected DCs capture and transfer viral particles to CD4 lymphocytes through a trans-enhancement mechanism in which chemokines are involved...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28118614/identification-of-risk-factors-and-the%C3%A2-pattern-of-lower-cervical-lymph-node-metastasis-in-esophageal-cancer-implications-for-radiotherapy-target-delineation
#5
Yijun Luo, Xiaoli Wang, Yuhui Liu, Chengang Wang, Yong Huang, Jinming Yu, Minghuan Li
Radiotherapy remains the important therapeutic strategy for patients with esophageal cancer (EC). At present, there is no uniform opinion or standard care on the range of radiotherapy in the treatment of EC patients. This study aimed to investigate the risk factors associated with lower cervical lymph node metastasis (LNM) and to explore the distribution pattern of lower cervical metastatic lymph nodes. It could provide useful information regarding accurate target volume delineation for EC. We identified 239 patients who initial diagnosed with esophageal squamous cell carcinoma...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28114742/5-step-harvest-of-supraclavicular-lymph-nodes-as-vascularized-free-tissue-transfer-for-treatment-of-lymphedema
#6
Adrian S H Ooi, David W Chang
No abstract text is available yet for this article.
January 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28110170/tailoring-polymeric-hybrid-micelles-with-lymph-node-targeting-ability-to-improve-the-potency-of-cancer-vaccines
#7
Qin Zeng, Hanmei Li, Hao Jiang, Jiao Yu, Ying Wang, Huan Ke, Tao Gong, Zhirong Zhang, Xun Sun
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs) and inadequate retention within LNs undoubtedly restrains their strength on activating T cell immunity. Here, we address this issue by tailoring the physicochemical properties of polymeric hybrid micelles (HMs), which are self-assembled from two amphiphilic diblock copolymers, poly-(ethylene glycol) phosphorethanolamine (PEG-PE) and polyethylenimine-stearic acid conjugate (PSA) via hydrophobic and electrostatic interactions...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28105647/abdominal-flap-for-closing-the-donor-site-after-groin-lymph-node-transfer
#8
Andrés A Maldonado, Rebecca M Garza, Jourdain Artz, David H Song, David W Chang
No abstract text is available yet for this article.
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28096423/trogocytosis-of-peptide-mhc-class-ii-complexes-from-dendritic-cells-confers-antigen-presenting-ability-on-basophils
#9
Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama
Th2 immunity plays important roles in both protective and allergic responses. Nevertheless, the nature of antigen-presenting cells responsible for Th2 cell differentiation remains ill-defined compared with the nature of the cells responsible for Th1 and Th17 cell differentiation. Basophils have attracted attention as a producer of Th2-inducing cytokine IL-4, whereas their MHC class II (MHC-II) expression and function as antigen-presenting cells are matters of considerable controversy. Here we revisited the MHC-II expression on basophils and explored its functional relevance in Th2 cell differentiation...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095507/choline-deficiency-causes-colonic-type-ii-natural-killer-t-nkt-cell-loss-and-alleviates-murine-colitis-under-type-i-nkt-cell-deficiency
#10
Shintaro Sagami, Yoshitaka Ueno, Shinji Tanaka, Akira Fujita, Hiroaki Niitsu, Ryohei Hayashi, Hideyuki Hyogo, Takao Hinoi, Yasuhiko Kitadai, Kazuaki Chayama
Serum levels of choline and its derivatives are lower in patients with inflammatory bowel disease (IBD) than in healthy individuals. However, the effect of choline deficiency on the severity of colitis has not been investigated. In the present study, we investigated the role of choline deficiency in dextran sulfate sodium (DSS)-induced colitis in mice. Methionine-choline-deficient (MCD) diet lowered the levels of type II natural killer T (NKT) cells in the colonic lamina propria, peritoneal cavity, and mesenteric lymph nodes, and increased the levels of type II NKT cells in the livers of wild-type B6 mice compared with that in mice fed a control (CTR) diet...
2017: PloS One
https://www.readbyqxmd.com/read/28063048/monitoring-and-modulation-of-inducible-foxp3-regulatory-t-cell-differentiation-in-the-lymph-nodes-draining-the-small-intestine-and-colon
#11
S Veenbergen, L A van Berkel, M F du Pré, A E Kozijn, Janneke N Samsom
The mucosa-draining lymphoid tissue favors differentiation of inducible Foxp3(+) regulatory T cells. Adoptive transfer of T-cell receptor (TCR) transgenic (Tg) T cells is a powerful tool to study antigen-specific regulatory T-cell differentiation in lymphoid tissues in vivo. The kinetics and nature of the T-cell response largely depend on the route of antigen administration and degree of clonal competition. Here, we describe that adoptive transfer of CD4(+) DO11.10 TCR Tg T cells can be used for monitoring Foxp3(+) regulatory T-cell differentiation in the gut-draining lymph nodes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28058777/platysma-sparing-vascularized-submental-lymph-node-flap-transfer-for-extremity-lymphedema
#12
Igor Poccia, Chia-Yu Lin, Ming-Huei Cheng
BACKGROUND AND OBJECTIVES: Due to its consistent vascular and lymphatic anatomy, the vascularized submental lymph node flap is a reliable option for lymphedema treatment. Despite these advantages, flap harvest requires resection of platysma, which may cause a marginal mandibular nerve pseudo-paralysis. The aim of this study was to investigate the donor site morbidity of an innovative platysma-sparing vascularized submental lymph node flap transfer for treating extremity lymphedema. METHODS: Ten patients undergoing platysma sparing submental lymph-node flap harvest were prospectively enrolled in the study and compared with a control group of 10 patients who underwent standard submental lymph-node flap harvest...
January 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28057015/downregulation-of-long-noncoding-rna-meg3-is-associated-with-poor-prognosis-and-promoter-hypermethylation-in-cervical-cancer
#13
Jun Zhang, Zhongqiu Lin, Yali Gao, Tingting Yao
BACKGROUND: Our previous study reported that MEG3 is an important tumor suppressor gene that is inactivated in cervical cancer. However, the diagnostic and prognostic values of MEG3, as well as the molecular mechanism of MEG3 inactivation in cervical cancer, remain unclear. In this study, we aimed to further elucidate the role and potential inactivation mechanism of MEG3 in cervical cancer. METHODS: ROC curve and Cox regression analyses were used to assess the diagnostic and prognostic value of MEG3 in patients with cervical cancer...
January 5, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28050201/neck-dissection-technique-commonality-and-variance-a-survey-on-neck-dissection-technique-preferences-among-head-and-neck-oncologic-surgeons-in-the-american-head-and-neck-society
#14
Shirin M Hemmat, Steven J Wang, William R Ryan
Introduction Neck dissection (ND) technique preferences are not well reported. Objective The objective of this study is to educate practitioners and trainees about surgical technique commonality and variance used by head and neck oncologic surgeons when performing a ND. Methods Online survey of surgeon members of the American Head and Neck Society (AHNS). Survey investigated respondents' demographic information, degree of surgical experience, ND technique preferences. Results In our study, 283 out of 1,010 (28%) AHNS surgeon members with a mean age of 50...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28040772/three-dimensional-virtual-bronchoscopy-using-a-tablet-computer-to-guide-real-time-transbronchial-needle-aspiration
#15
Alfonso Fiorelli, Antonio Raucci, Roberto Cascone, Alfonso Reginelli, Davide Di Natale, Carlo Santoriello, Antonio Capuozzo, Roberto Grassi, Nicola Serra, Mario Polverino, Mario Santini
OBJECTIVES: We proposed a new virtual bronchoscopy tool to improve the accuracy of traditional transbronchial needle aspiration for mediastinal staging. METHODS: Chest-computed tomographic images (1 mm thickness) were reconstructed with Osirix software to produce a virtual bronchoscopic simulation. The target adenopathy was identified by measuring its distance from the carina on multiplanar reconstruction images. The static images were uploaded in iMovie Software, which produced a virtual bronchoscopic movie from the images; the movie was then transferred to a tablet computer to provide real-time guidance during a biopsy...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28026929/near-infrared-quantum-dot-and-89-zr-dual-labeled-nanoparticles-for-in-vivo-cerenkov-imaging
#16
Yiming Zhao, Travis M Shaffer, Sudeep Das, Carlos Pérez-Medina, Willem J M Mulder, Jan Grimm
Cerenkov luminescence (CL) is an emerging imaging modality that utilizes the light generated during the radioactive decay of many clinical used isotopes. Although it is increasingly used for background-free imaging and deep tissue photodynamic therapy, in vivo applications of CL suffer from limited tissue penetration. Here, we propose to use quantum dots (QDs) as spectral converters that can transfer the CL UV-blue emissions to near-infrared light that is less scattered or absorbed in vivo. Experiments on tissue phantoms showed enhanced penetration depth and increased transmitted intensity for CL in the presence of near-infrared (NIR) QDs...
February 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28009597/a-review-of-treatment-for-breast-cancer-related-lymphedema-paradigms-for-clinical-practice
#17
Timothy D Smile, Rahul Tendulkar, Graham Schwarz, Douglas Arthur, Stephen Grobmyer, Stephanie Valente, Frank Vicini, Chirag Shah
OBJECTIVES: Breast cancer-related lymphedema (BCRL) represents a major complication of breast cancer treatment, impacting the quality of life for breast cancer survivors that develop it. The purpose of this review is to evaluate the literature surrounding BCRL treatment modalities to guide clinicians regarding risk-stratified treatment options. METHODS: A review of studies over a 10-year period (January 2006 to February 2016) was performed. Noninvasive strategies evaluated included compression therapy, manual lymphatic drainage, and complex decongestive therapy (CDT)...
December 22, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28007431/quantifying-in-vivo-murine-antigen-specific-t-cell-responses-without-requirement-for-prior-knowledge-of-antigen-identity
#18
Nour Kibbi, Enping Hong, Harib Ezaldein, Douglas Hanlon, Tarek Fahmy, Richard Edelson
Extracorporeal Photochemotherapy (ECP) is a widely applied anti-cancer immunotherapy for patients with cutaneous T cell lymphoma (CTCL). By using apoptotic malignant cells as a source of patient-specific tumor antigen, it enables clinically relevant and curative anti-CTCL immunity, with potential efficacy in other tumors. Currentmethods to track patient-specific responses are tedious, and new methods are needed to assess putative global immunity. We developed a clinically practical method to assess antigen-specific T cell activation that does not rely on knowledge of the particular antigen, thereby eliminating the requirement for patient-specific reagents...
November 30, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27999828/a-case-of-abdominal-mesenteric-castleman-s-disease-with-left-renal-cell-carcinoma-and-stomach-leiomyoma
#19
Shunjun Chen, Lele Song, Xinli Xie, Xingmin Han, Bing Cheng
: A rare case of abdominal mesenteric Castleman's disease with left renal cell carcinoma and stomach leiomyoma is reported. A 57 years old male patient was transferred to our hospital for investigation of a left kidney tumor. Physical examination and routine laboratory tests were normal. Multi mode imaging by 64-slices spiral computed tomography (CT) scan, the enhanced CT scan and the fluorine-18-fluorodeoxyglucose positron emission tomography/CT ((18)F-FDG PET/CT) scan were applied. Computed tomography showed a 5...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27999746/low-molecular-weight-hyaluronan-lmw-ha-accelerates-lymph-node-metastasis-of-melanoma-cells-by-inducing-disruption-of-lymphatic-intercellular-adhesion
#20
Yan Du, Manlin Cao, Yiwen Liu, Yiqing He, Cuixia Yang, Man Wu, Guoliang Zhang, Feng Gao
Endothelial integrity defects initiate lymphatic metastasis of tumor cells. Low-molecular-weight hyaluronan (LMW-HA) derived from plasma and interstitial fluid was reported to be associated with tumor lymphatic metastasis. In addition, LMW-HA was proved to disrupt lymphatic vessel endothelium integrity, thus promoting lymphatic metastasis of tumor cells. Until now, there are few reports on how LMW-HA modulates lymphatic endothelial cells adhesion junctions and affects cancer cells metastasizing into lymph vessels...
2016: Oncoimmunology
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