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https://www.readbyqxmd.com/read/28790247/-pulmonary-mucoepidermoid-carcinoma-with-hilar-lymph-node-metastasis-complicated-by-myelodysplastic-syndrome
#1
Yoshinari Matsuda, Hiroshi Moriyama, Masashi Inaba, Yoshihiko Kubo, Masahiro Kitada, Satoshi Hayashi, Kei Ishibashi, Satoshi Okazaki, Nana Takahashi, Shunsuke Yasuda, Masahiro Abe, Satoshi Hirata
A 65-year-old woman was found to have a mass shadow on chest computed tomography. The patient had been diagnosed as having myelodysplastic syndrome 3 years before admission. She was transferred to our hospital for further examination of the mass in the lower lobe of left lung. The mass was positron emission tomography-positive (SUVmax of 8.6)suggesting a malignant neoplasm. Serum concentrations of carcinoembryonic antigen was elevated to 8.7 ng/ml. Preoperative laboratory studies showed anemia (hemoglobin 6...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28783695/tissue-specific-emergence-of-regulatory-and-intraepithelial-t-cells-from-a-clonal-t-cell-precursor
#2
Angelina M Bilate, Djenet Bousbaine, Luka Mesin, Marianna Agudelo, Justin Leube, Andreas Kratzert, Stephanie K Dougan, Gabriel D Victora, Hidde L Ploegh
Peripheral Foxp3(+) regulatory T cells (pTregs) maintain immune homeostasis by controlling potentially harmful effector T cell responses toward dietary and microbial antigens. Although the identity of the T cell receptor (TCR) can impose commitment and functional specialization of T cells, less is known about how TCR identity governs pTreg development from conventional CD4(+) T cells. To investigate the extent to which TCR identity dictates pTreg fate, we used somatic cell nuclear transfer to generate a transnuclear (TN) mouse carrying a monoclonal TCR from a pTreg (pTreg TN mice)...
August 26, 2016: Science Immunology
https://www.readbyqxmd.com/read/28783468/evaluation-of-experimental-infection-with-l-l-amazonensis-in-x-linked-immunodeficient-mice
#3
Patricia Xander, Wagner Francisco Kennerly Marcondes Gonzaga, Mariana Marques Geraldo, Bruno Camolese Vivanco, Ana Flavia Popi, Mario Mariano, Wagner Luiz Batista
B-1 cells are a subtype of B cells with peculiar characteristics. These cells are distinct from B-2 lymphocytes in their morphology, ontogeny, tissue distribution and phenotypic functional features. B-1 cells can participate in the immune response in several ways, for example, by being recruited to inflammatory foci, producing large amounts of IL-10 cytokine, and differentiating into IgM-secreting cells or phagocytes. Nevertheless, the role of B-1 cells in the pathogenesis of experimental leishmaniasis has not been fully elucidated...
August 7, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28767735/engaging-the-cd40-cd40l-pathway-augments-t-helper-cell-responses-and-improves-control-of-mycobacterium-tuberculosis-infection
#4
Jonathan Kevin Sia, Erica Bizzell, Ranjna Madan-Lala, Jyothi Rengarajan
Mycobacterium tuberculosis (Mtb) impairs dendritic cell (DC) functions and induces suboptimal antigen-specific CD4 T cell immune responses that are poorly protective. Mucosal T-helper cells producing IFN-γ (Th1) and IL-17 (Th17) are important for protecting against tuberculosis (TB), but the mechanisms by which DCs generate antigen-specific T-helper responses during Mtb infection are not well defined. We previously reported that Mtb impairs CD40 expression on DCs and restricts Th1 and Th17 responses. We now demonstrate that CD40-dependent costimulation is required to generate IL-17 responses to Mtb...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28763794/targeting-latency-associated-peptide-promotes-antitumor-immunity
#5
Galina Gabriely, Andre P da Cunha, Rafael M Rezende, Brendan Kenyon, Asaf Madi, Tyler Vandeventer, Nathaniel Skillin, Stephen Rubino, Lucien Garo, Maria A Mazzola, Panagiota Kolypetri, Amanda J Lanser, Thais Moreira, Ana Maria C Faria, Hans Lassmann, Vijay Kuchroo, Gopal Murugaiyan, Howard L Weiner
Regulatory T cells (Tregs) promote cancer by suppressing antitumor immune responses. We found that anti-LAP antibody, which targets the latency-associated peptide (LAP)/transforming growth factor-β (TGF-β) complex on Tregs and other cells, enhances antitumor immune responses and reduces tumor growth in models of melanoma, colorectal carcinoma, and glioblastoma. Anti-LAP decreases LAP(+) Tregs, tolerogenic dendritic cells, and TGF-β secretion and is associated with CD8(+) T cell activation. Anti-LAP increases infiltration of tumors by cytotoxic CD8(+) T cells and reduces CD103(+) CD8 T cells in draining lymph nodes and the spleen...
May 19, 2017: Science Immunology
https://www.readbyqxmd.com/read/28753156/-adipose-derived-stem-cells-and-vascularized-lymph-node-transfers-successfully-treat-mouse-hindlimb-secondary-lymphedema-by-early-reconnection-of-the-lymphatic-system-and-lymphangiogenesis
#6
Chenglong Wang, Jie Luan, Minqiang Xin
No abstract text is available yet for this article.
July 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28753154/adipose-derived-stem-cells-and-vascularized-lymph-node-transfers-successfully-treat-mouse-hindlimb-secondary-lymphedema-by-early-reconnection-of-the-lymphatic-system-and-lymphangiogenesis
#7
https://www.readbyqxmd.com/read/28748529/dual-role-of-monocyte-derived-dendritic-cells-in-trypanosoma-cruzi-infection
#8
Carolina V Poncini, Stella M González-Cappa
Pathogens can cause inflammation when inoculated into the skin. The vector-transmitted protozoan parasite Trypanosoma cruzi induces poor cellular-infiltration and disseminates, causing high mortality in the experimental model. Here, we characterized the inflammatory foci at the parasite inoculation site and secondary lymphoid organs using a murine system. While no macrophages and few neutrophils and monocytes (Mo) were recruited into the skin, T. cruzi infection elicited the mobilization of Ly6C(+) Mo to draining lymph nodes and spleen...
July 27, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28746237/abdominoplasty-with-lymphatic-microsurgery-for-patients-with-secondary-lower-extremity-lymphedema
#9
Shinsuke Akita, Yoshihisa Yamaji, Hideki Tokumoto, Naoki Adachi, Yoshitaro Sasahara, Yoshitaka Kubota, Motone Kuriyama, Nobuyuki Mitsukawa
BACKGROUND: Patients with secondary lower extremity lymphedema (LEL) often develop suprapubic lymphedema. We developed a novel surgical method of shaping the lower abdomen and debulking suprapubic lymphedema with simultaneous reconstruction of lymphatic flow in case of LEL. METHODS: A skin incision in a fleur-de-lis pattern was performed for horizontal and vertical abdominal skin and fat resection. A caudal-based isosceles triangular flap was created on the central suprapubic region to reduce wound tension at the intersection of the horizontal and vertical incisions...
July 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28733739/variation-and-treatment-of-vessels-in-laparoscopic-right-hemicolectomy
#10
Kai Ye, Jianan Lin, Yafeng Sun, Yiyang Wu, Jianhua Xu, Songbing He
BACKGROUND: With the introduction of complete mesocolic excision (CME) and the application of laparoscopic technique, surgery for colon cancer has become more standardized and the curative effect has improved [1]. The key points in laparoscopic right hemicolectomy are high ligation of main vessels and root dissection of lymph nodes. The wide range of variations in vascular architecture and intraoperative bleeding are common causes of prolonged surgical time, wound hemorrhage, and even transfer to the opening operation...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28716438/the-impact-of-knowledge-transfer-on-the-detection-of-venous-invasion-in-colorectal-cancer
#11
Richard Kirsch, Naziheh Assarzadegan, David E Messenger, Ari Juda, Robert H Riddell, Aaron Pollett, Catherine J Streutker, Dimitrios X Divaris, Ken J Newell, Russell G Price, Sharyn Smith, Sahar Al-Haddad, Jeremy R Parfitt, David K Driman
Venous invasion (VI) is an independent predictor of hematogenous metastasis and mortality in colorectal cancer (CRC), yet remains widely under-reported. Its detection may require recognition of subtle morphologic clues which at times are only unmasked with an elastin stain. This study evaluates the impact of a knowledge transfer initiative (KTI) on VI detection in a "real world" pathology practice setting. Following participation in an interobserver variability study of VI detection (Kirsch et al 2013), twelve participants received educational materials highlighting key issues in VI detection...
July 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28703913/a-suum-infection-modulates-inflammation-implication-of-cd4-cd25-hi-foxp3-t-cells-and-il-10
#12
Tiago de Oliveira Titz, Claudia Andréa Alves de Araújo, Cristina Satomi Enobe, Paula Ordonhez Rigato, Telma Miyuki Oshiro, Maria Fernanda de Macedo-Soares
Helminth infections have the ability to modulate host's immune response through mechanisms that allow the chronic persistence of the worms in the host. Here, we investigated the mechanisms involved on the suppressive effect of Ascaris suum infection using a murine experimental model of LPS-induced inflammation. We found that infection with A. suum markedly inhibited leukocyte influx induced by LPS into air pouches, suppressed secretion of pro-inflammatory cytokines (IL-1β, TNF-α and IL-6) and induced high levels of IL-10 and TGF-β...
July 13, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28695707/comparison-of-long-term-clinical-outcomes-among-different-vascularized-lymph-node-transfers-6-year-experience-of-a-single-center-s-approach-to-the-treatment-of-lymphedema
#13
Pedro Ciudad, Mouchammed Agko, John Jaime Perez Coca, Oscar J Manrique, Wei-Ling Chang, Fabio Nicoli, Shih-Heng Chen, Hung-Chi Chen
BACKGROUND: This study evaluated the long-term clinical outcomes among different vascularized lymph node transfers (VLNT) used at our institution. METHODS: Between July 2010 and July 2016, all patients with International Society of Lymphology (ISL) stages II-III who underwent VLNT were evaluated. Demographic and clinical data (limb circumference, infectious episodes, lymphoscintigraphic studies) were recorded pre-operatively. Clinical outcomes, complications, and additional excisional procedures were analyzed post-operatively...
July 10, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28679373/a-comprehensive-overview-on-the-surgical-management-of-secondary-lymphedema-of-the-upper-and-lower-extremities-related-to-prior-oncologic-therapies
#14
REVIEW
Ramon Garza, Roman Skoracki, Karen Hock, Stephen P Povoski
Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer patients. For the upper extremities, it is most commonly associated with prior oncologic therapies for breast cancer, while for the lower extremities, it is most commonly associated with oncologic therapies for gynecologic cancers, urologic cancers, melanoma, and lymphoma. Both non-surgical and surgical management strategies have been developed and utilized, with the primary goal of all management strategies being volume reduction of the affected extremity, improvement in patient symptomology, and the reduction/elimination of resultant extremity-related morbidities, including recurrent infections...
July 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28676898/-recovery-of-paraffin-blocks-and-central-archiving-experiences-of-the-kiel-lymph-node-registry-and-the-german-study-group-for-hodgkin-lymphoma
#15
M Čavčić, I Oschlies, M Fuchs, A Engert, W Klapper
BACKGROUND: Central collection of tissue blocks for pathological and translational research is particularly important in rare diseases. Transfer of tissue blocks from primary to central pathology is of crucial importance. OBJECTIVES: We aimed to answer the following questions: Has the transfer of tissue blocks sent for consultation or within clinical trials changed over the last 20 years? What are the reasons for reclaiming tissue blocks by the primary pathology and what actions would convince primary pathologists to leave the blocks in the reference pathology? MATERIAL AND METHODS: The first 100 biopsies of each year between 1995 and 2015 (n = 2100), as well as all tissue transfers within therapeutic studies (n = 1405, German Hodgkin Study Group, GHSG) between 1998 and 2015, were analyzed separately for block reclaims using the Department of Pathology database...
July 4, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28665492/antigen-presenting-cell-targeted-proinsulin-expression-converts-insulin-specific-cd8-t-cell-priming-to-tolerance-in-autoimmune-prone-nod-mice
#16
Peta L S Reeves, Rajeev Rudraraju, F Susan Wong, Emma E Hamilton-Williams, Raymond J Steptoe
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic β cells. Therapies need to incorporate strategies to overcome the genetic defects that impair induction or maintenance of peripheral T-cell tolerance and contribute to disease development. We tested whether the enforced expression of an islet autoantigen in antigen-presenting cells (APC) counteracted peripheral T-cell tolerance defects in autoimmune-prone NOD mice. We observed that insulin-specific CD8(+) T cells transferred to mice in which proinsulin was transgenically expressed in APCs underwent several rounds of division and the majority were deleted...
June 30, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28660639/the-role-of-regulatory-t-cells-in-thymectomy-induced-autoimmune-ovarian-disease
#17
Yajun Dong, Hongmei Li, Yuyan Li, Yonggang Liu, Huiling Chen, Pingping Xu, Tingting Zhao, Wei He
PROBLEM: To evaluate the role of regulatory T (Treg) cells in autoimmune ovarian disease (AOD). METHOD OF STUDY: AOD model was set up by thymectomy of BALB/C mice on day 3 (d3tx). The variation of T lymphocyte subsets, especially the Treg cells were analyzed in the peripheral blood, spleen, para-aortic, and inguinal lymph nodes in d3tx mice. The effect of Treg cells on AOD was further evaluated by adoptive transfer of Treg cells into d3tx mice (d3tx+Treg). RESULTS: In d3tx mice, the ratio of Treg/CD4(+) was significantly increased rapidly from 1st to 2nd week, rapidly declined in 3rd week, then decreased slowly until the 9th week...
June 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28655472/induction-of-skin-pathogenic-th22-cells-by-epicutaneous-allergen-exposure
#18
Ivana Glocova, Jürgen Brück, Julia Geisel, Eva Müller-Hermelink, Katja Widmaier, Amir S Yazdi, Martin Röcken, Kamran Ghoreschi
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease with dysfunction of the skin barrier, an abnormal immune response and frequent allergies to environmental antigens like food antigens. Clinical observations suggest that certain diets can influence the course of AD. OBJECTIVE: Here we compared the phenotype of food allergen-specific T cells activated through skin or gut allergen exposure to transfer skin inflammation into naïve recipients upon epicutaenous allergen challenge...
June 9, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28617989/1-25-dihydroxyvitamin-d3-induced-dendritic-cells-suppress-experimental-autoimmune-encephalomyelitis-by-increasing-proportions-of-the-regulatory-lymphocytes-and-reducing-th1-th17-cells
#19
Zhongxiang Xie, Jingtao Chen, Chao Zheng, Jing Wu, Yun Cheng, Shan Zhu, Chenhong Lin, Qingqing Cao, Jie Zhu, Tao Jin
Dendritic cells (DCs), a bridge of innate and adaptive immune responses, play a key role in the development of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Administration of tolerogenic DCs has been used as an immunotherapy in the autoimmune diseases. Deficiency of vitamin D is an environmental risk factor of MS. In this study, we induced tolerogenic DCs by 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and adoptive transferred the tolerogenic DCs (VD3-DCs) into EAE mice...
June 15, 2017: Immunology
https://www.readbyqxmd.com/read/28616231/lymph-node-transfer-for-refractory-infectious-sites-caused-by-trauma
#20
Makoto Mihara, Hisako Hara, Kazuki Kikuchi
OBJECTIVE: In this report, we placed focus on the immunological function of lymph nodes and performed lymph node transfer via a free flap to a site of refractory infection. CASE AND RESULTS: Case 1 describes a 34-year-old male suffering from compound fractures with severe crush injuries and burns in the right ankle joint. A 20 × 15 cm skin defect was observed around the right malleolus medialis, along with denuded tendons with bacterial infection. After conservative treatment, we transferred a lymph-node-containing free superficial circumflex iliac artery perforator flap to the region, with minimum debridement...
2017: SAGE open medical case reports
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