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drug-induced nephrotoxicity

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https://www.readbyqxmd.com/read/28919990/pharmacological-targeting-of-peptidylarginine-deiminase-4-prevents-cancer-associated-kidney-injury-in-mice
#1
Jessica Cedervall, Anca Dragomir, Falk Saupe, Yanyu Zhang, Johan Ärnlöv, Erik Larsson, Anna Dimberg, Anders Larsson, Anna-Karin Olsson
Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal treatment efficacy. Despite the severity of this cancer-associated pathology, the molecular mechanisms, as well as therapeutic options, are still largely lacking. We here show that formation of intravascular tumor-induced neutrophil extracellular traps (NETs) is a cause of kidney injury in tumor-bearing mice...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28913815/pharmacokinetic-pharmacodynamic-analysis-of-cisplatin-with-hydration-and-mannitol-diuresis-the-contribution-of-urine-cisplatin-concentration-to-nephrotoxicity
#2
Keizo Fukushima, Akira Okada, Hiroyuki Oe, Mika Hirasaki, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Nobuyuki Sugioka
BACKGROUND AND OBJECTIVES: Forced diuresis, high-volume hydration with diuresis, is widely used as a prophylactic treatment against cisplatin nephrotoxicity. However, the details of the underlying mechanisms and the optimal protocol of forced diuresis remain unclear. The present study investigated the alterations in pharmacokinetics and pharmacodynamics (nephrotoxicity) of cisplatin with forced diuresis treatment. METHODS: Cisplatin (5 mg/kg) was intravenously injected to rats (5 rats/group, except for control group in pharmacodynamic study, n = 13) treated with or without forced diuresis 2-h pre- and post-hydration with 10% mannitol at different infusion rates (0...
September 14, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28911689/effect-of-oleuropein-against-chemotherapy-drug-induced-histological-changes-oxidative-stress-and-dna-damages-in-rat-kidney-injury
#3
Fatime Geyikoglu, Murat Emir, Suat Colak, Kubra Koc, Hasan Turkez, Murat Bakir, Mirkhalil Hosseinigouzdagani, Salim Cerig, Osman Nuri Keles, Nihal Simsek Ozek
Cisplatin-based chemotherapy is responsible for a large number of renal failures, and it is still associated with high rates of mortality today. Oleuropein (OLE) presents a plethora of pharmacological beneficial properties. In this study we investigated whether OLE could provide sufficient protection against cisplatin-induced nephrotoxicity. With this aim, Sprague-Dawley rats were divided into eight groups: control; 7 mg/kg/d cisplatin, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE; and treatment with OLE for 3 days starting at 24 hours following cisplatin injection...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904656/reversal-of-tenofovir-induced-nephrotoxicity-case-reports-of-two-patients
#4
Fatuma Some, Mathew Koech, Emily Chesire, Gabriel Kigen
The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded that the magnitude may not be that significant. We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28885000/multi-platform-approach-for-the-discovery-of-novel-drug-induced-kidney-injury-biomarkers
#5
Liuxi Chen, James D Smith, Jaromir Mikl, Ryan Fryer, Frank Pack, Brad J Williams, Jonathan Phillips, Vladimir Papov
Drug-induced kidney injury (DIKI) is a common toxicity observed in pharmaceutical development. We demonstrate the use of label-free liquid chromatography - mass spectrometry (LC-MS) and multiplex liquid chromatography-single reaction monitoring (LC-SRM) as practical extensions of standard immunoassay based safety biomarker assessments for identification of new toxicity marker candidates and for improved mechanistic understanding. Two different anti-cancer drugs doxorubicin (DOX) and cisplatin (cis-diamminedichloridoplatinum, CDDP) were chosen as the toxicants due to their different modes of nephrotoxicity...
September 8, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28870684/isoliquiritigenin-pretreatment-attenuates-cisplatin-induced-proximal-tubular-cells-llc-pk1-death-and-enhances-the-toxicity-induced-by-this-drug-in-bladder-cancer-t24%C3%A2-cell-line
#6
Angela Patricia Moreno-Londoño, Claudia Bello-Alvarez, José Pedraza-Chaverri
Cisplatin is an effective antineoplastic agent widely used in the treatment of solid tumors, however, it induces nephrotoxicity. Cisplatin-induced nephrotoxicity is associated with increased reactive oxygen species (ROS) production and decreased antioxidant system defense in kidney. Isoliquiritigenin (IsoLQ) is a chalcone, which is characterized by its antioxidant and antiinflammatory properties. Herein, we investigated the protective effect of IsoLQ on LLC-PK1 proximal tubular cells against cisplatin-induced death and its effect on the antineoplastic activity of cisplatin on bladder cancer T24 cell line...
September 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28868009/good-tolerance-to-full-dose-crizotinib-in-a-patient-with-anaplastic-lymphoma-receptor-tyrosine-kinase-rearranged-lung-adenocarcinoma-and-preexisting-renal-impairment
#7
Adeline Rosoux, Fabrice Duplaquet, Sebahat Ocak
BACKGROUND: Crizotinib is an approved tyrosine kinase inhibitor in the treatment of advanced-stage non-small-cell lung cancer patients with anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangement. Renal dysfunction after crizotinib administration was recently reported, but the physiopathological explanation and the safety in patients with preexisting renal dysfunction are still not clear. CASE PRESENTATION: A 44-year-old female and current smoker was diagnosed with a stage IV lung adenocarcinoma and treated with five lines of chemotherapy during a 4-year period of time...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28828347/the-role-of-gamma-amino-butyric-acid-in-cisplatin-induced-nephrotoxicity-in-streptozotocin-induced-diabetic-rats
#8
Masoomeh Nasiri, Nepton Soltani, Safoora Mazaheri, Maryam Maleki, Ardeshir Talebi, Fatemah Gharibi, Mehdi Nematbakhsh
BACKGROUND: Diabetes mellitus can change the risk of developing cancer. Cisplatin (CP) is a common antineoplastic drug. The major side effect of CP is nephrotoxicity. Gamma amino butyric acid (GABA) is an antioxidant agent that may have a protective role against CP-induced nephrotoxicity. The aim of the present study was to investigate the role of GABA in CP-induced nephrotoxicity in hyperglycemic male and female rats. MATERIALS AND METHODS: Sixty male and female Wistar diabetic rats were used in ten experimental groups...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28815461/drug-induced-kidney-injury-in-the-elderly
#9
REVIEW
Sana Khan, Valentina Loi, Mitchell H Rosner
The incidence of acute kidney injury in the elderly has grown over the past decade. One of the primary drivers is drug-induced nephrotoxicity, which is the result of a combination of the unique susceptibilities to kidney injury and the increased use of medications in the elderly population. Specific drug classes are associated with increased rates of kidney injury including agents that block the renin angiotensin system, antimicrobials, and chemotherapeutic agents. Mechanistically, injury may be due to hemodynamic effects, tubular or glomerular toxicity, and interstitial nephritis...
August 16, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28800174/curcumin-ameliorates-diclofenac-sodium-induced-nephrotoxicity-in-male-albino-rats
#10
Ahmady Y Ahmed, Amany M Gad, Ola M Abd El-Raouf
Exposure to drugs often results in toxicity in the kidney which represents the major control system maintaining homeostasis of the body and thus is especially susceptible to xenobiotics. Nephrotoxicity is a life-threatening side-effect of nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac is one of the most frequently prescribed NSAIDs and have been reported to cause multiple organs damage. Curcumin (CUR) exhibits nephroprotective properties. Therefore, rats were divided into four groups; rats of groups 3 and 4 received diclofenac (100 mg/kg, i...
August 11, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28797532/assessment-of-in-vitro-antifungal-efficacy-and-in-vivo-toxicity-of-amphotericin-b-loaded-plga-and-plga-peg-blend-nanoparticles
#11
T C Moraes Moreira Carraro, C Altmeyer, N Maissar Khalil, R Mara Mainardes
Amphotericin B (AmB) is widely applied in treatment of systemic fungal infections. However, the emergence of severe adverse effects, such as nephrotoxicity, hepatotoxicity and hemolytic anemia, can limit its clinical use. Poly(lactide-co-glycolide) (PLGA) or poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) blend nanoparticles containing AmB were developed with the aim to decrease AmB toxicity and propose the oral route for AmB delivery. Nanoparticles were characterized by particle size, polydispersity index, Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction analyses...
August 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28796263/mir-30c-regulates-cisplatin-induced-apoptosis-of-renal-tubular-epithelial-cells-by-targeting-bnip3l-and-hspa5
#12
Bin Du, Xiao-Meng Dai, Shuang Li, Guo-Long Qi, Guang-Xu Cao, Ying Zhong, Pei-di Yin, Xue-Song Yang
As a common anticancer drug, cisplatin has been widely used for treating tumors in the clinic. However, its side effects, especially its nephrotoxicity, noticeably restrict the application of cisplatin. Therefore, it is imperative to investigate the mechanism of renal injury and explore the corresponding remedies. In this study, we showed the phenotypes of the renal tubules and epithelial cell death as well as elevated cleaved-caspase3- and TUNEL-positive cells in rats intraperitoneally injected with cisplatin...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28774864/administration-of-colistin-sulfate-in-endotoxic-model-at-slow-and-sustained-fashion-may-reverse-shock-without-causing-nephrotoxicity-in-its-optimal-concentration
#13
Anwarul Haque, Yoshikazu Ishii, Yoshikiyo Akasaka, Tetsuya Matsumoto, Kazuhiro Tateda
OBJECTIVES: Despite of proven LPS neutralizing activity, intravenous polymyxin use was waned due to experience of associated nephrotoxicity. But, increasing resistance to all available antibiotics has necessitated their resurgence and the prodrug of colistin sulfate (CS), known as colistin-methanesulfonate (CMS), is increasingly used as the only therapeutic option in many infections. Currently available CMS employ very different dose definitions and thus because of complex pharmacokinetics/pharmacodynamics information and short half-life, this drug use remains confusing...
July 31, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28758697/renal-toxicity-and-chemotherapy-in-children-with-cancer-nephrotoxicity-and-cancer-treatment
#14
REVIEW
A Ruggiero, P Ferrara, G Attinà, D Rizzo, R Riccardi
Antineoplastic drugs' clinical use can be limited by different drug-induced toxicities. Of these, renal dysfunction may be one of the most troublesome in that it can be cumulative and in general is only partially reversible with the discontinuation of the treatment. Renal toxicity may be manifested as a reduction of the glomerular filtration rate, electrolyte imbalances, or frank renal failure. Careful assessment of renal function has to be performed taking into account that the impairment of the renal function is initially silent and only later may be clinically dramatic...
July 31, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28757873/absence-of-relationship-between-mitochondrial-dna-haplogroups-and-cisplatin-induced-hearing-loss
#15
D Graterol, C Mir, C Garcia-Vaquero, I Braña, A N Pardo, M I Rochera-Villach, A Lyakhovich, M E LLeonart, J Lorente
BACKGROUND: Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity. OBJECTIVE: We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss. STUDY DESIGN AND METHODS: This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment...
2017: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/28750665/renal-damage-induced-by-pemetrexed-causing-drug-discontinuation-a-case-report-and-review-of-the-literature
#16
Yassir Sbitti, Hafsa Chahdi, Khaoula Slimani, Adil Debbagh, Anouar Mokhlis, Abderrahmane Albouzidi, Fahd Bennani, Hassan Errihani, Mohamed Ichou
BACKGROUND: Pemetrexed maintenance therapy holds tremendous potential in improving the survival of patients with advanced pulmonary adenocarcinoma. Major side effects include myelosuppression and cutaneous reactions. However, little data are available on pemetrexed nephrotoxicity. Our case describes clinically relevant renal events leading to treatment discontinuation in routine practice. CASE PRESENTATION: We report a case of a 69-year-old Moroccan man treated for metastatic non-small cell lung cancer...
July 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28721084/urinary-timp2%C3%A2-igfbp7-for-the-prediction-of-platinum-induced-acute-renal-injury
#17
Moritz Schanz, Anette Hoferer, Jing Shi, Mark Dominik Alscher, Martin Kimmel
INTRODUCTION: Platinum-based chemotherapy (PBC) is a potent antineoplastic treatment, but cisplatin nephrotoxicity is often the limiting factor. Identifying the patients who are at risk for developing platinum-induced renal injury is an important issue. We tested urinary TIMP2·IGFBP7, a new US Food and Drug Administration (FDA)-cleared test to assess the risk of acute kidney injury (AKI), in a cohort of patients with malignant neoplastic disease receiving PBC. PATIENTS AND METHODS: A total of 58 patients with malignant neoplastic disease were enrolled in this study, of whom 32 patients had both urine samples and subsequent serum creatinine values available for detecting AKI within 72 hours...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28714420/evaluation-of-temporal-changes-in-urine-based-metabolomic-and-kidney-injury-markers-to-detect-compound-induced-acute-kidney-tubular-toxicity-in-beagle-dogs
#18
M P Wagoner, Y Yang, J E McDuffie, M Klapczynski, W Buck, L Cheatham, D Eisinger, F Sace, K M Lynch, M Sonee, J-Y Ma, Y Chen, K Marshall, M Damour, L Stephen, Y P Dragan, J Fikes, S Snook, L B Kinter
Urinary protein biomarkers and metabolomic markers have been leveraged to detect acute drug induced kidney injury (DIKI) in rats; however, the utility of these indicators to enable early detection of DIKI in canine models has not been well documented. Therefore, we evaluated temporal changes in biomarkers and metabolites in urine from male and female beagle dogs. Gentamicin-induced kidney lesions in male dogs were characterized by moderate to severe tubular epithelial cell degeneration/necrosis, epithelial cell regeneration and dilation; and a unique urine-based metabolomic fingerprint...
July 13, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28703736/nephroprotective-effects-of-saponins-from-leaves-of-panax-quinquefolius-against-cisplatin-induced-acute-kidney-injury
#19
Zhi-Na Ma, Yan-Zi Li, Wei Li, Xiao-Tong Yan, Ge Yang, Jing Zhang, Li-Chun Zhao, Li-Min Yang
Although cisplatin is an anticancer drug that has activity against malignant tumor, it often causes nephrotoxicity. Previous reports have confirmed that the saponins from the leaves of P. quinquefolium (PQS) exerted many pharmacological activities. However, the renoprotective effects of PQS were still unknown. The purpose of the present research was to discuss renoprotective effect of PQS in a mouse model of cisplatin-induced acute kidney injury (AKI). The levels of blood urea nitrogen (BUN) and serum creatinine (CRE) were evidently increased in cisplatin-intoxicated mice, which were reversed by PQS...
July 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28689766/acute-administration-of-tramadol-and-tapentadol-at-effective-analgesic-and-maximum-tolerated-doses-causes-hepato-and-nephrotoxic-effects-in-wistar-rats
#20
COMPARATIVE STUDY
Joana Barbosa, Juliana Faria, Sandra Leal, Luís Pedro Afonso, João Lobo, Odília Queirós, Roxana Moreira, Félix Carvalho, Ricardo Jorge Dinis-Oliveira
Tramadol and tapentadol are two atypical synthetic opioid analgesics, with monoamine reuptake inhibition properties. Mainly aimed at the treatment of moderate to severe pain, these drugs are extensively prescribed for multiple clinical applications. Along with the increase in their use, there has been an increment in their abuse, and consequently in the reported number of adverse reactions and intoxications. However, little is known about their mechanisms of toxicity. In this study, we have analyzed the in vivo toxicological effects in liver and kidney resulting from an acute exposure of a rodent animal model to both opioids...
August 15, 2017: Toxicology
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