keyword
https://read.qxmd.com/read/38469902/a-comprehensive-analysis-of-liver-safety-across-zibotentan-oncology-trials-knowledge-of-the-past-offers-new-perspectives-on-the-present
#21
JOURNAL ARTICLE
Anna Fettiplace, Sherri Matis-Mitchell, Oleksandr Molodetskyi, Malin Söderbergh, Jan Oscarsson, Min Lin, Srivathsa Ravikiran, Martin Billger, Philip Ambery
BACKGROUND: Endothelin receptor antagonists (ERAs) are associated with liver injury. We used data from previous oncology clinical trials to determine the liver safety profile of zibotentan, which is currently in clinical development (in combination with dapagliflozin) for chronic kidney disease and cirrhosis. RESEARCH DESIGN AND METHODS: Six global, double-blinded, phase 2b and 3 clinical trials from the zibotentan oncology development program were pooled to analyze liver safety...
March 12, 2024: Expert Opinion on Drug Safety
https://read.qxmd.com/read/38469128/severe-dengue-infection-unmasking-drug-induced-liver-injury-successful-management-with-n-acetylcysteine
#22
Naveen Gautam, Nishan Shrestha, Sanjeev Bhandari, Sabin Thapaliya
KEY CLINICAL MESSAGE: Clinicians in tuberculosis and dengue endemic regions should have heightened vigilance for drug-induced liver injury (DILI) overlapping with active infections, enabling prompt recognition and life-saving conservative management. ABSTRACT: Severe dengue and drug-induced liver injury (DILI) are significant independent risk factors for acute liver failure. The co-occurrence of these conditions significantly complicates clinical management. Here, we describe the case of a 21-year-old Nepali female who developed acute liver failure during antitubercular therapy (ATT)...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38466883/validation-of-the-revised-electronic-version-of-rucam-for-diagnosis-of-dili-in-chinese-patients
#23
JOURNAL ARTICLE
Xinyan Zhao, Yan Wang, Rongtao Lai, Xiaojin Wang, Yuecheng Yu, Min Li, Hong Zhao, Zikun Ma, Mengqi Li, Tiantian Guo, Xiao Han, Yao Meng, Mengmeng Zhang, Yu Su, Kunyan Hao, You Deng, Yuanyuan Kong, Zhenyu Li, Qing Xie, Wen Xie, Chengwei Chen, Jidong Jia
BACKGROUND AIMS: The Revised Electronic Causality Assessment Method (RECAM), a computerized update of the Roussel Uclaf Causality Assessment Methodology (RUCAM), was recently proposed. In this study, we validated and compared the utility of the RECAM and RUCAM in Chinese patients with a single conventional or herbal agent-induced liver injury. METHODS: In this retrospective multicenter cohort of well-established DILI and non-DILI patients from 5 centers in China, the diagnostic performance of the RUCAM and RECAM was compared by AUC analysis...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466551/pediatric-acute-liver-failure-current-perspective-in-etiology-and-management
#24
REVIEW
Arghya Samanta, Ujjal Poddar
Pediatric acute liver failure (PALF) is a catastrophic clinical condition with very high morbidity and mortality without early detection and intervention. It is characterized by the acute onset of massive hepatocellular injury that releases circulating inflammatory mediators, resulting in metabolic disturbances, coagulopathy, hepatic encephalopathy and multi-organ failure. The etiological spectrum is dominated by hepatotropic viruses, drug-induced liver injury, metabolic and genetic disorders and immune-mediated diseases...
March 11, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38465923/beyond-the-hype-and-towards-application-liver-complex-in-vitro-models-in-preclinical-drug-safety
#25
REVIEW
Sushma Jadalannagari, Lorna Ewart
INTRODUCTION: Drug induced Liver-Injury (DILI) is a leading cause of drug attrition and complex in vitro models (CIVMs), including three dimensional (3D) spheroids, 3D bio printed tissues and flow-based systems, could improve preclinical prediction. Although CIVMs have demonstrated good sensitivity and specificity in DILI detection their adoption remains limited. AREAS COVERED: This article describes DILI, the challenges with its prediction and the current strategies and models that are being used...
March 11, 2024: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/38465578/human-chemically-derived-hepatic-progenitors-hcdhs-as-a-source-of-liver-organoid-generation-application-in-regenerative-medicine-disease-modeling-and-toxicology-testing
#26
JOURNAL ARTICLE
Soraya Salas-Silva, Yohan Kim, Tae Hun Kim, Myounghoi Kim, Daekwan Seo, Jeonghoon Choi, Valentina M Factor, Haeng Ran Seo, Yeonhwa Song, Gyu Sung Choi, Yun Kyung Jung, Kungsik Kim, Kyeong Geun Lee, Jaemin Jeong, Ji Hyun Shin, Dongho Choi
BACKGROUND & AIMS: Several types of human stem cells from embryonic (ESCs) and induced pluripotent (iPSCs) to adult tissue-specific stem cells are commonly used to generate 3D liver organoids for modeling tissue physiology and disease. We have recently established a protocol for direct conversion of primary human hepatocytes (hPHs) from healthy donor livers into bipotent progenitor cells (hCdHs). Here we extended this culture system to generate hCdH-derived liver organoids for diverse biomedical applications...
December 2023: Biomaterials
https://read.qxmd.com/read/38464725/targeting-ferroptosis-unveils-a-new-era-for-traditional-chinese-medicine-a-scientific-metrology-study
#27
Siyang Cao, Yihao Wei, Yaohang Yue, Yingqi Chen, Shuai Liao, Aikang Li, Peng Liu, Ao Xiong, Hui Zeng
In the past 11 years, there has been a surge in studies exploring the regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, a significant gap persists in comprehensive scientometric analysis and scientific mapping research, especially in tracking the evolution, primary contributors, and emerging research focal points. This study aims to comprehensively update the advancements in targeting ferroptosis with various TCMs during the previous 11 years. The data, covering the period from 1 January 2012, to 30 November 2023, were retrieved from the Web of Science database...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38460297/new-advances-in-the-study-of-pd-1-pd-l1-inhibitors-induced-liver-injury
#28
REVIEW
Meijun Yue, Chunyu Li, Guohui Li
The application of immune checkpoint inhibitors (ICIs) has made extraordinary achievements in tumor treatment. Among them, programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors can improve the prognosis of advanced tumors, and have been widely used in clinical practice to treat many types of cancers. However, excessive immune response can also induce immune-related adverse events (irAEs) involving many organs. Of these, immune-related liver injury is the relatively common and carries the highest morbidity, which has attracted the attention of hepatologists all over the world...
March 8, 2024: International Immunopharmacology
https://read.qxmd.com/read/38458296/novel-green-based-polyglycerol-polymeric-nanoparticles-loaded-with-ferulic-acid-a-promising-approach-for-hepatoprotection
#29
JOURNAL ARTICLE
Mariam H Mahmoud, Riham I El-Gogary, Mahmoud E Soliman, Amany O Kamel
In the pursuit of eco-friendly and sustainable materials, polyglycerol diacid polymers hold immense promise for drug delivery compared to those derived from fossil fuels. Harnessing this potential, we aimed to prepare nanoparticles (NPs) derived from sustainable polymers, loaded with ferulic acid (FA), a natural polyphenolic compound known for its shielding effect against liver-damaging agents, including carbon tetrachloride (CCl4). Glycerol was esterified with renewable monomers, such as succinic acid, adipic acid, and/or FA, resulting in the creation of a novel class of polyglycerol diacid polymers...
March 6, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38458224/therapeutic-potential-of-diosgenin-in-amelioration-of-carbon-tetrachloride-induced-murine-liver-injury
#30
JOURNAL ARTICLE
Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghani
Diosgenin is a sapogenin with antidiabetic, antioxidant, and anti-inflammatory properties. The current study investigated whether diosgenin could ameliorate carbon tetrachloride (CCL4)-induced liver injury. To cause liver injury, CCL4 was injected intraperitoneally twice a week for 8 weeks. Daily oral administration of diosgenin at doses of 20, 40, and 80 mg/kg was started one day before CCL4 injection and continued for 8 weeks. Finally, serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also albumin were assessed...
March 8, 2024: Drug Research
https://read.qxmd.com/read/38458086/ginseng-derived-nanoparticles-alleviate-alcohol-induced-liver-injury-by-activating-the-nrf2-ho-1-signalling-pathway-and-inhibiting-the-nf-%C3%AE%C2%BAb-signalling-pathway-in-vitro-and-in-vivo
#31
JOURNAL ARTICLE
Wenjing Li, Song Yang, Yueming Zhao, Giada Di Nunzio, Limei Ren, Liangliang Fan, Ronghua Zhao, Daqing Zhao, Jiawen Wang
BACKGROUND: Previous studies have confirmed the antioxidant and anti-inflammatory effects of active ginseng components that protect against liver injury. However, ginseng-derived nanoparticles (GDNPs), low-immunogenicity nanovesicles derived from ginseng, have not been reported to be hepatoprotective. PURPOSE: In this study, we investigated whether GDNPs could attenuate alcohol-induced liver injury in LO2 cells and mice by modulating oxidative stress and inflammatory pathways, thereby advancing the theoretical basis for the development of novel pharmacological treatments...
February 25, 2024: Phytomedicine
https://read.qxmd.com/read/38455771/a-case-report-demonstrating-the-favorable-outcomes-of-using-n-acetylcysteine-nac-in-managing-hepatic-injury-induced-by-amphetamine-related-drug-toxicity-do-we-underestimate-its-potential
#32
Gagan Aulakh, Arshdeep Singh
A 59-year-old male with a history of alcohol abuse presented with altered mental status. Upon examination, he was hypertensive and lethargic, and laboratory results revealed severe transaminitis, coagulopathy, and lactic acidosis, despite having normal serum alcohol levels. Additionally, his urine drug screen tested positive for methamphetamine. Following the exclusion of infectious, autoimmune, and other common causes of acute hepatitis, a diagnosis of methamphetamine-induced acute hepatitis was established...
February 2024: Curēus
https://read.qxmd.com/read/38451034/drug-induced-liver-injury-dili-ascribed-to-non-steroidal-anti-inflammatory-drugs-nsaids-in-the-usa-update-with-genetic-correlations
#33
JOURNAL ARTICLE
Herbert L Bonkovsky, Marwan Ghabril, Paola Nicoletti, Andrew Dellinger, Robert J Fontana, Huiman Barnhart, Jiezhun Gu, Ann K Daly, Guruprasad P Aithal, Elizabeth J Phillips, David E Kleiner
OBJECTIVE: To describe patients with NSAID-DILI, including genetic factors associated with idiosyncratic DILI. METHODS: In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delphic approach. HLA sequencing of multiethnic NSAID-DILI patients and HLA allele imputation of matching population controls were performed following overall, class and drug-based association analysis. Significant results were tested in a non-Hispanic White (NHW) case-control replication cohort...
March 7, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38445150/tuberculosis-in-a-liver-cirrhosis-patient-a-management-conundrum
#34
Pradnya M Diggikar, Hansini R Reddy, Mayank Mundada, Tushar Pancholi, Ahsan A Faruqi
This case report delves into the intricate challenges of managing tuberculosis (TB) in a 70-year-old male with decompensated chronic liver disease (DCLD) and a history of endoscopic variceal ligation. The patient, initially presenting with symptoms such as black-colored stools, breathlessness, and weight loss, was diagnosed with right-sided pneumonia alongside DCLD. Despite the administration of standard beta-lactam plus macrolide antibiotics, the patient exhibited no improvement. Subsequent bronchoscopy revealed Mycobacterium tuberculosis (MTB), prompting the initiation of first-line anti-tubercular therapy...
February 2024: Curēus
https://read.qxmd.com/read/38441860/targeting-pi3k-akt-in-cerebral-ischemia-reperfusion-injury-alleviation-from-signaling-networks-to-targeted-therapy
#35
REVIEW
Ting Zheng, Taotao Jiang, Hongxiang Ma, Yanping Zhu, Manxia Wang
Ischemia/reperfusion (I/R) injury is a pathological event that results in reperfusion due to low blood flow to an organ. Cerebral ischemia is a common cerebrovascular disease with high mortality, and reperfusion is the current standard intervention. However, reperfusion may further induce cellular damage and dysfunction known as cerebral ischemia/reperfusion injury (CIRI). Currently, strategies for the clinical management of CIRI are limited, necessitating the exploration of novel and efficacious treatment modalities for the benefit of patients...
March 5, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38436510/changing-trajectories-of-alanine-aminotransferase-and-risk-of-antituberculosis-drug-induced-liver-injury-in-chinese-patients-a-cohort-study
#36
JOURNAL ARTICLE
Xinyu Chen, Hongqiu Pan, Zhuolu Hao, Honggang Yi, Shaowen Tang
Antituberculosis drug-induced liver injury (ATLI) is a major adverse effect during antituberculosis treatment. Early detection or prediction is essential to prevent ATLI in antituberculosis treatment patients. The purpose of this work is to explore the relationship between alanine aminotransferase (ALT) trajectories within 15 days of initial treatment and the risk of ATLI. Based on a historical cohort of patients hospitalized for antituberculosis treatment and group-based trajectory modeling analysis, ALT trajectories within 15 days of initial treatment were determined...
March 4, 2024: Journal of Clinical Pharmacology
https://read.qxmd.com/read/38436196/autoimmune-liver-disease-triggered-by-sars-cov-2-a-case-report-and-review-of-the-literature
#37
JOURNAL ARTICLE
D Fanni, C Gerosa, G Serra, M Miglianti, F Coghe, P Van Eyken, G Faa, G La Nasa, M Guido
BACKGROUND: An increasing number of coronavirus disease 2019 (COVID-19) related autoimmune hepatitis (AIH) and autoimmune liver disease (AILD) has been already described so far in the last three years. This rise has set up some diagnostic and therapeutic concerns, although steroid therapy has mostly been efficient, avoiding main significant side effects. CASE REPORT: We report the case of a 52-year-old subject displaying liver function impairment at the laboratory tests while positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) swab...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38436159/oleuropein-a-phenolic-component-of-olea-europaea-l-ameliorates-ccl4-induced-liver-injury-in-rats-through-the-regulation-of-oxidative-stress-and-inflammation
#38
JOURNAL ARTICLE
A H Rahmani, A Almatroudi, K S Allemailem, H O A Alharbi, A Y Babiker, S A Althwab, N Alsuhaymi, M H Alsugoor, A A Khan, W A I Al-Megrin
OBJECTIVE: This study aimed to assess the hepatoprotective role of oleuropein (Olp), a phenolic compound found in olive, against carbon tetrachloride (CCl4)-induced liver damage in rats. MATERIALS AND METHODS: The research involved male albino rats, which received intraperitoneal injections of 100 mg/kg b.w. of oleuropein for 8 consecutive weeks before being subjected to carbon tetrachloride (CCl4) at a dosage of 1.0 ml/kg b.w. Changes induced by CCl4 in antioxidant and inflammatory marker levels were assessed using ELISA assay kits...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38434489/the-evolution-of-circulating-biomarkers-for-use-in-acetaminophen-paracetamol-induced-liver-injury-in-humans-a-scoping-review
#39
JOURNAL ARTICLE
Mitchell R McGill, Steven C Curry
Acetaminophen (APAP) is a widely used drug, but overdose can cause severe acute liver injury. The first reports of APAP hepatotoxicity in humans were published in 1966, shortly after the development of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as the first biomarkers of liver injury as opposed to liver function. Thus, the field of liver injury biomarkers has evolved alongside the growth in APAP hepatotoxicity incidence. Numerous biomarkers have been proposed for use in the management of APAP overdose patients in the intervening years...
December 2023: Livers
https://read.qxmd.com/read/38432925/-pharmacogenetic-testing-for-prevention-of-severe-cutaneous-adverse-drug-reactions
#40
JOURNAL ARTICLE
Taisei Mushiroda
Pharmacogenetic testing benefits patients by predicting drug efficacy and risk of adverse drug reactions (ADRs). Pharmacogenetic biomarkers useful in clinical practice include drug-metabolizing enzyme and drug transporter genes and human leukocyte antigen (HLA) genes. HLA genes, which are important molecules involved in human immunity, have long been analyzed for associations with ADRs, such as skin rash, drug-induced liver injury, and agranulocytosis. HLA is composed of many genes, each of which has dozens of different types (alleles), and many HLA alleles associated with ADRs have been reported...
2024: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
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