keyword
https://read.qxmd.com/read/38493495/rapid-self-assembly-mini-livers-protect-mice-against-severe-hepatectomy-induced-liver-failure
#1
JOURNAL ARTICLE
Miaomiao Luo, Jiahui Lai, Enhua Zhang, Yue Ma, Runbang He, Lina Mao, Bo Deng, Junjin Zhu, Yan Ding, Jialyu Huang, Bin Xue, Qiangsong Wang, Mingming Zhang, Pengyu Huang
The construction of bioartificial livers, such as liver organoids, offers significant promise for disease modeling, drug development, and regenerative medicine. However, existing methods for generating liver organoids have limitations, including lengthy and complex processes (taking 6-8 weeks or longer), safety concerns associated with pluripotency, limited functionality of pluripotent stem cell-derived hepatocytes, and small, highly variable sizes (typically ≈50-500 µm in diameter). Prolonged culture also leads to the formation of necrotic cores, further restricting size and function...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38489768/glycocalyx-mimicking-nanoparticles-with-differential-organ-selectivity-for-drug-delivery-and-therapy
#2
JOURNAL ARTICLE
Dohyeon Kim, Chang-Hee Whang, Jungwoo Hong, Monica Celine Prayogo, Wonsik Jung, Seojung Lee, Hocheol Shin, Yujin Kim, Jiyoung Yu, Min Joong Kim, Kyunggon Kim, Hee-Seung Lee, Sangyong Jon
Organ-selective drug delivery is expected to maximize the efficacy of various therapeutic modalities while minimizing their systemic toxicity. Lipid nanoparticles and polymersomes can direct the organ-selective delivery of mRNAs or gene editing machineries, but their delivery has been limited to mostly liver, spleen, and lung. We urgently need a platform that enables delivery to these and other target organs. Here, we generate a library of glycocalyx-mimicking nanoparticles (GlyNPs) comprising five randomly combined sugar moieties and use direct in vivo library screening to identify GlyNPs with preferential biodistribution in liver, spleen, lung, kidneys, heart, and brain...
March 15, 2024: Advanced Materials
https://read.qxmd.com/read/38489722/apathetic-graves-disease-with-severe-hepatic-and-renal-dysfunction-induced-by-covid-19-infection-case-report-and-literature-review
#3
JOURNAL ARTICLE
Liting Deng, Yingtong Zhang, Huilin Sun
RATIONALE: A rare and intractable case of apathetic Graves' disease (GD) with severe liver and kidney damage induced by coronavirus disease 2019 (COVID-19) carries a certain risk of missing diagnosis and delayed treatment during the COVID-19 pandemic. PATIENT CONCERN: A 60-year-old female patient developed anorexia, exhaustion, jaundice, nausea, and vomiting 10 days after COVID-19 infection. She was admitted to the Infectious Diseases Department because of recurring symptoms for more than a month...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38487735/new-classification-of-drug-induced-liver-injury-dili-in-aasld-guidance-what-is-next
#4
EDITORIAL
Cemal Nuri Ercin
No abstract text is available yet for this article.
2024: Hepatol Forum
https://read.qxmd.com/read/38487332/successful-switch-to-ofatumumab-after-liver-injury-associated-with-ocrelizumab-treatment-in-multiple-sclerosis-a-case-report
#5
Alice Mariottini, Alessandro Barilaro, Antonio Lotti, Fabio Marra, Luca Massacesi
Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolone pulsed therapy used in case of MS relapse. DILI may be induced by different mechanisms, including idiosyncratic reaction, autoimmune hepatitis or viral reactivation. In patients receiving the humanized anti-CD20 monoclonal antibody (mAb) ocrelizumab, DILI has been rarely reported and was mostly associated with hepatitis B virus (HBV) reactivation...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38486722/short-chain-fatty-acids-in-nonalcoholic-fatty-liver-disease-new-prospects-for-short-chain-fatty-acids-as-therapeutic-targets
#6
REVIEW
Xinyu Li, Maozhang He, Xinrui Yi, Xuejin Lu, Meizi Zhu, Min Xue, Yunshu Tang, Yaling Zhu
Nonalcoholic fatty liver disease (NAFLD) is a stress-induced liver injury related to heredity, environmental exposure and the gut microbiome metabolism. Short-chain fatty acids (SCFAs), the metabolites of gut microbiota (GM), participate in the regulation of hepatic steatosis and inflammation through the gut-liver axis, which play an important role in the alleviation of NAFLD. However, little progress has been made in systematically elucidating the mechanism of how SCFAs improve NAFLD, especially the epigenetic mechanisms and the potential therapeutic application as clinical treatment for NAFLD...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38485561/immune-mediated-hepatitis-basic-concepts-and-treatment
#7
REVIEW
J A Velarde-Ruiz Velasco, D K Tapia Calderón, S Cerpa-Cruz, J A Velarde-Chávez, J F Uribe Martínez, E S García Jiménez, J M Aldana Ledesma, Á Díaz-González, J Crespo
Immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized advanced cancer management. Nevertheless, the generalized use of these medications has led to an increase in the incidence of adverse immune-mediated events and the liver is one of the most frequently affected organs. Liver involvement associated with the administration of immunotherapy is known as immune-mediated hepatitis (IMH), whose incidence and clinical characteristics have been described by different authors. It often presents as mild elevations of amino transferase levels, seen in routine blood tests, that spontaneously return to normal, but it can also manifest as severe transaminitis, possibly leading to the permanent discontinuation of treatment...
March 13, 2024: Revista de Gastroenterología de México
https://read.qxmd.com/read/38485279/-cyp7a1-gene-induction-via-shp-dependent-or-independent-mechanisms-can-increase-the-risk-of-drug-induced-liver-injury-independently-or-in-synergy-with-bsep-inhibition
#8
JOURNAL ARTICLE
Congrong Niu, Xiaodong Xie, Renmeng Liu, Xiaomin Liang, Yiding Hu, Yurong Lai
Drug-induced liver injury (DILI) is a frequent cause of clinical trial failures during drug development. While inhibiting BSEP is a well-documented DILI mechanism, interference with genes related to bile acid (BA) metabolism and transport can further complicate DILI development. Here, the effects of twenty-eight compounds on genes associated with BA metabolism and transport were evaluated, including those with discontinued development or use, boxed warnings, and clean labels for DILI. The study also included rifampicin and omeprazole, PXR and AhR ligands, and four mitogen-activated protein kinase kinase (MEK1/2) inhibitors...
March 14, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/38484826/aldo-keto-reductase-7a2-protects-against-atorvastatin-induced-hepatotoxicity-via-nrf2-activation
#9
JOURNAL ARTICLE
Dan Li, Jiajin Chen, Fei Zhou, Wenhe Zhang, Hongyu Chen
Atorvastatin (ATO), as a cholesterol-lowering drug, was the world's best-selling drug in the early 2000s. However, ATO overdose-induced liver or muscle injury is a threat to many patients, which restricts its application. Previous studies suggest that ATO overdose is accompanied with ROS accumulation and increased lipid peroxidation, which are the leading causes of ATO-induced liver damage. This study is, therefore, carried out to investigate the roles of anti-oxidant pathways and enzymes in protection against ATO-induced hepatotoxicity...
March 12, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38483145/an-optimized-short-term-steroid-therapy-for-chronic-drug-induced-liver-injury-a-prospective-randomized-clinical-trial
#10
JOURNAL ARTICLE
Ang Huang, Yun Zhu, Shuhong Liu, Ying Sun, Zherui Liu, Qing-Sheng Liang, Jun Zhao, Bin-Xia Chang, Jing-Feng Bi, Jiang-Tao Liu, Xing-Ran Zhai, Huan Xie, Ning Li, Hui Tian, Lin Han, Yingjie Zhuang, Hongbin Ma, Guang-Ju Teng, Wei Zhang, Guruprasad P Aithal, Dong Ji, Jingmin Zhao, Zhengsheng Zou
BACKGROUND AND AIMS: The use of corticosteroids in chronic drug-induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with chronic DILI benefited from a 48-week steroid stepwise reduction (SSR) regimen. However, it remains unclear whether a shorter course of therapy can achieve similar efficacy. In this study, we aimed to assess whether a 36-week SSR can achieve efficacy similar to that of 48-week SSR. METHODS: A randomized open-label trial was performed...
March 14, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38482670/liver-toxicity-in-oncology-trials-and-beyond-a-simplified-concept-for-management-of-hepatocellular-drug-induced-liver-injury-in-patients-with-abnormal-baseline-liver-tests
#11
JOURNAL ARTICLE
Michael Merz, Anna Fettiplace, John Marcinak, Hans L Tillmann, Don C Rockey, Gerd A Kullak-Ublick
BACKGROUND: Management of side effects in clinical trials has to balance generationof meaningful data with risk for patients. A toxicity area requiring detailedmanagement guidelines is drug-induced liver injury (DILI).In oncology trials, patients are often included despite baseline livertest abnormalities, for whom there is no consensus yet on levels of liver testchanges that should trigger action, such as drug interruption ordiscontinuation. METHODS: We provide an innovative approach to manage hepatocellular DILI inoncology trials for patients with abnormal baseline alanineaminotransferase (ALT) levels...
March 14, 2024: Expert Opinion on Drug Safety
https://read.qxmd.com/read/38481390/natural-antibodies-are-required-for-clearance-of-necrotic-cells-and-recovery-from-acute-liver-injury
#12
JOURNAL ARTICLE
Matheus Silvério Mattos, Sofie Vandendriessche, Sara Schuermans, Lars Feyaerts, Nadine Hövelmeyer, Ari Waisman, Pedro Elias Marques
BACKGROUND & AIMS: Hepatocellular necrosis is common in both acute and chronic liver injury and may evolve to fibrosis and liver failure. Injury leads to accumulation of necrotic cell debris in the liver, which drives persistent inflammation and poor recovery. This study investigated the role of natural antibodies (NAbs) in the clearance of necrotic cells in the injured liver, their impact on tissue regeneration and their potential as a therapy for acute liver injury. METHODS: We used murine models of drug-induced liver injury and focal thermal injury in immunocompetent and antibody-deficient mice ( Rag2 -/- and IgMi)...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38479481/comparative-histologic-features-among-liver-biopsies-with-biliary-pattern-injury-and-confirmed-clinical-diagnoses
#13
JOURNAL ARTICLE
Sanhong Yu, Barbara Vidal, Masa Peric, Matthew W Rosenbaum, Justin M M Cates, Raul S Gonzalez
Biliary-pattern injury in the liver (eg, duct injury, ductular reaction, cholestasis) can occur in several conditions, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), large duct obstruction (LDO), and drug-induced liver injury (DILI). While the histologic changes in these conditions have been individually well described, distinguishing among them remains often challenging, particularly when biopsy samples are limited in size, robust clinical information is unavailable, and/or the pathologist does not feel confident in evaluating liver disease...
March 11, 2024: Human Pathology
https://read.qxmd.com/read/38476888/sex-differences-in-diabetes%C3%A2-induced-hepatic-and-renal-damage
#14
JOURNAL ARTICLE
Linghuan Gao, Xindi Wang, Lei Guo, Wenli Zhang, Gengyin Wang, Shuying Han, Yuxin Zhang
Diabetes mellitus (DM) is a disease that affects millions of individuals worldwide and is characterized by abnormal glucose metabolism that can induce severe damage to numerous organs throughout the body. Sex differences have been demonstrated in a number of factors associated with diabetes and its complications, such as diabetic kidney disease and diabetic liver disease. To investigate the sex differences in DM further, the changes in the weight, food and water intake, and blood sugar of mice were recorded for 8 weeks in the present study...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38475962/orosomucoid-2-upregulation-mediates-liver-injury-induced-colorectal-cancer-liver-metastasis-by-promoting-emt-and-cell-migration
#15
JOURNAL ARTICLE
Xundong Wei, Lei Wang, Bing Yang, Yuanyuan Ma, Wei Yuan, Jie Ma
The relationship between drug-induced liver injury and liver metastasis of colorectal cancer and the underlying mechanisms are not well understood. In this study, we used carbon tetrachloride to construct a classic mouse liver injury model and injected CT26 colorectal cancer cells into the mouse spleen to simulate the natural route of colorectal cancer liver metastasis. Liver injury significantly increased the number of colorectal cancer liver metastases. Transcriptome sequencing and data-independent acquisition protein quantification identified proteins that were significantly differentially expressed in injured livers, and orosomucoid (ORM) 2 was identified as a target protein for tumor liver metastasis...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38474249/exploring-individual-variability-in-drug-induced-liver-injury-dili-responses-through-metabolomic-analysis
#16
JOURNAL ARTICLE
Marta Moreno-Torres, Guillermo Quintás, Teresa Martínez-Sena, Ramiro Jover, José V Castell
Drug-induced liver injury (DILI) is a serious adverse hepatic event presenting diagnostic and prognostic challenges. The clinical categorization of DILI into hepatocellular, cholestatic, or mixed phenotype is based on serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) values; however, this classification may not capture the full spectrum of DILI subtypes. With this aim, we explored the utility of assessing changes in the plasma metabolomic profiles of 79 DILI patients assessed by the RUCAM (Roussel Uclaf Causality Assessment Method) score to better characterize this condition and compare results obtained with the standard clinical characterization...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473913/hemochromatosis-ferroptosis-ros-gut-microbiome-and-clinical-challenges-with-alcohol-as-confounding-variable
#17
REVIEW
Rolf Teschke
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472759/optimization-of-microwave-assisted-extraction-process-of-total-flavonoids-from-salicornia-bigelovii-torr-and-its-hepatoprotective-effect-on-alcoholic-liver-injury-mice
#18
JOURNAL ARTICLE
Dujun Wang, Jing Lv, Yan Fu, Yueling Shang, Jinbin Liu, Yongmei Lyu, Ming Wei, Xiaohong Yu
The objective of this study was to determine the optimal extraction conditions for total flavonoids from S. bigelovii using microwave-assisted extraction and to analyze the protective effect of total flavonoids from S. bigelovii on alcoholic liver injury in mice. The optimization of the process conditions for the microwave-assisted extraction of total flavonoids from S. bigelovii was performed using response surface methodology, and an alcohol-induced acute liver injury model in mice was used to investigate the effects of different doses of total flavonoids (100 mg/kg, 200 mg/kg, and 400 mg/kg) on the levels and activities of serum alanine aminotransferase kits (ALT), glutamic oxaloacetic transaminase kits (AST), superoxide dismutase kits (SOD), glutathione peroxidase kits (GSH-Px), and malondialdehyde (MDA)...
February 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472195/elevated-kallistatin-promotes-the-occurrence-and-progression-of-non-alcoholic-fatty-liver-disease
#19
JOURNAL ARTICLE
Zhenzhen Fang, Gang Shen, Yina Wang, Fuyan Hong, Xiumei Tang, Yongcheng Zeng, Ting Zhang, Huanyi Liu, Yanmei Li, Jinhong Wang, Jing Zhang, Anton Gao, Weiwei Qi, Xia Yang, Ti Zhou, Guoquan Gao
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and the development of non-alcoholic steatohepatitis (NASH) might cause irreversible hepatic damage. Hyperlipidemia (HLP) is the leading risk factor for NAFLD. This study aims to illuminate the causative contributor and potential mechanism of Kallistatin (KAL) mediating HLP to NAFLD. 221 healthy control and 253 HLP subjects, 62 healthy control and 44 NAFLD subjects were enrolled. The plasma KAL was significantly elevated in HLP subjects, especially in hypertriglyceridemia (HTG) subjects, and positively correlated with liver injury...
March 12, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38469943/perturbations-in-human-bile-acid-profiles-following-drug-induced-liver-injury-investigated-using-semitargeted-high-resolution-mass-spectrometry
#20
JOURNAL ARTICLE
Myriam Mireault, Christopher F Rose, Constantine J Karvellas, Lekha Sleno
RATIONALE: Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in North America. To investigate the effect of drug-induced liver injury (DILI) on circulating bile acid (BA) profiles, serum from ALF patients and healthy controls were analyzed using a semitargeted high-resolution mass spectrometry approach to measure BAs in their unconjugated and amidated forms and their glucuronide and sulfate conjugates. METHODS: Human serum samples from 20 healthy volunteers and 34 ALF patients were combined with deuterated BAs and extracted, prior to liquid chromatography high-resolution tandem mass spectrometry analysis...
May 15, 2024: Rapid Communications in Mass Spectrometry: RCM
keyword
keyword
61893
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.