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Hemovigilance

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https://www.readbyqxmd.com/read/28414063/hypersensitivity-transfusion-reactions-due-to-iga-deficiency-are-rare-according-to-french-hemovigilance-data
#1
Charles Tacquard, Karim Boudjedir, Monique Carlier, Jean-Yves Muller, Philippe Gomis, Paul Michel Mertes
In an analysis of a large French hemovigilance database (2004-2014), hypersensitivity transfusion reactions (HTRs) due to IgA deficiency were extremely rare with an frequency far lower than reported so far. In depth investigation of HTRs for IgA deficiency should be limited to moderate to severe recurrent reactions.
April 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28369916/feeling-the-burn-the-significant-burden-of-febrile-nonhemolytic-transfusion-reactions
#2
Robert Cohen, Alioska Escorcia, Farzana Tasmin, Ana Lima, Yulia Lin, Lani Lieberman, Jacob Pendergrast, Jeannie Callum, Christine Cserti-Gazdewich
BACKGROUND: Febrile nonhemolytic transfusion reactions (FNHTRs) are characterized by a post-transfusion temperature rise (of ≥ 1°C, to ≥ 38°C) or chills/rigors unrelated to the underlying condition. FNHTRs are provoked by inflammatory cytokines in the product or by host antileukocyte antibodies against residual donor leukocytes. FNHTRs are among the most commonly reported transfusion disturbances and are generally deemed nonserious events. However, their impact on patients and hospitals may be underestimated...
March 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28185278/zika-virus-and-blood-transfusion-the-experience-of-french-polynesia
#3
Damien Bierlaire, Sylvie Mauguin, Julien Broult, Didier Musso
BACKGROUND: Between October 2013 and March 2014, French Polynesia experienced the largest Zika virus (ZIKV) outbreak ever described before the emergence of ZIKV in the Americas in 2015. As arbovirus transfusion-transmitted (TT) infections have been previously reported, we hypothesized that transfusion of blood products could also transmit ZIKV. STUDY DESIGN AND METHODS: Mitigation strategies to prevent ZIKV-TT infections included nonspecific measures and the implementation of a laboratory developed ZIKV-specific nucleic acid testing (NAT) assay...
March 2017: Transfusion
https://www.readbyqxmd.com/read/28144952/unique-clinical-courses-of-transfusion-transmitted-hepatitis-e-in-patients-with-immunosuppression
#4
Masahiro Satake, Keiji Matsubayashi, Yuji Hoshi, Rikizo Taira, Yasumi Furui, Norihiro Kokudo, Nobuhisa Akamatsu, Tomoharu Yoshizumi, Nobuhiro Ohkohchi, Hiroaki Okamoto, Masato Miyoshi, Akinori Tamura, Kyoko Fuse, Kenji Tadokoro
BACKGROUND: The high prevalence of specific immunoglobulin G for hepatitis E virus (HEV) in Japanese people raises the possibility of a high incidence of HEV-viremic blood donors and therefore frequent transfusion-transmitted HEV (TT-HEV). STUDY DESIGN AND METHODS: TT-HEV cases established in Japan through hemovigilance and those published in the literature were collected. Infectivity of HEV-contaminated blood components and disease severity in relation to immunosuppression were investigated...
January 31, 2017: Transfusion
https://www.readbyqxmd.com/read/28073616/challenges-and-research-in-managing-blood-supply-in-china
#5
REVIEW
Yongming Zhu, Dongfu Xie, Xun Wang, Kaicheng Qian
Although considerable progress has been made in improving the blood service system in China over the last 2 decades, many challenges remain. A number of issues have received public attentions; however, others continue to be underacknowledged and controversial. This article describes 3 of these important and less emphasized issues: first, the ambiguity of the definition of voluntary nonremunerated blood donation and its relationship to an adequate blood supply; second, the current inadequacies of cost recovery from the blood service system; and third, the lack of a universally implemented program of hemovigilance...
December 5, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/27959967/transfusion-80%C3%A2-c-frozen-blood-products-are-safe-and-effective-in-military-casualty-care
#6
Femke Noorman, Thijs T C F van Dongen, Marie-Christine J Plat, John F Badloe, John R Hess, Rigo Hoencamp
INTRODUCTION: The Netherlands Armed Forces use -80°C frozen red blood cells (RBCs), plasma and platelets combined with regular liquid stored RBCs, for the treatment of (military) casualties in Medical Treatment Facilities abroad. Our objective was to assess and compare the use of -80°C frozen blood products in combination with the different transfusion protocols and their effect on the outcome of trauma casualties. MATERIALS AND METHODS: Hemovigilance and combat casualties data from Afghanistan 2006-2010 for 272 (military) trauma casualties with or without massive transfusions (MT: ≥6 RBC/24hr, N = 82 and non-MT: 1-5 RBC/24hr, N = 190) were analyzed retrospectively...
2016: PloS One
https://www.readbyqxmd.com/read/27955922/-hemovigilance-state-2007-2013%C3%A2-tunis
#7
S Mahjoub, H Baccouche, A Raissi, L Ben Hamed, N Ben Romdhane
INTRODUCTION: Despite its lifesaving role, blood transfusion still has risks associated with it. Hemovigilance is a set of surveillance procedures of the transfusion chain intended to promote safe and effective use of blood components. This work aims to present a descriptive analysis of adverse reactions, which were notified over a period of 5 years (incidence and etiology); to identify malfunctions and to propose corrections. MATERIALS AND METHODS: All transfusion adverse reactions accidents reported to the blood bank of the hospital La Rabta (n=120) are explored (clinical and laboratory tests)...
February 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/27923518/the-impact-of-emerging-infectious-diseases-on-chinese-blood-safety
#8
REVIEW
Miao He, Jingxing Wang, Limin Chen, Jing Liu, Peibin Zeng
Emerging infectious diseases (EIDs) have always been one of the major threats to public health. Although the implementation of mandatory testing for 4 classical transfusion-transmitted infectious-human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis-has reduced the transfusion risk of these pathogens, the potential threat of various EID agents and their constantly evolving variants to blood safety in China is not fully understood. This review presents 9 representative EID agents that are autochthonous and epidemic nationally or regionally in China...
November 4, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/27914916/-cytotoxicity-of-natural-anti-hla-antibodies-in-moroccan-patients-awaiting-for-kidney-transplantation
#9
Nadia Benseffaj, Sanae Ouadghiri, Asmaa Drissi Bourhanbour, Asmae Noor Zerrouki, Malika Essakalli
The presence of anti-HLA antibodies in the serum of a patient result from an immune response produced during an immunizing event as transfusion, pregnancy or graft. These antibodies can be cytotoxic by activating the complement pathway via C1q and may cause organ rejection during the transplant. Some male patients awaiting kidney transplantation are seropositive for anti-HLA antibodies when they have no immunizing antecedent event. These antibodies are qualified as natural antibodies. Our work is to assess the cytotoxicity of natural anti-HLA antibodies in patients followed at the immunology laboratory of the blood transfusion service and hemovigilance (STSH) as part of the kidney transplant...
November 30, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27774608/hemovigilance-in-massachusetts-and-the-adoption-of-statewide-hospital-blood-bank-reporting-using-the-national-healthcare-safety-network
#10
Melissa Cumming, Anthony Osinski, Lynne O'Hearn, Pamela Waksmonski, Michele Herman, Deborah Gordon, Elzbieta Griffiths, Kim Knox, Eileen McHale, Karen Quillen, Jorge Rios, Patricia Pisciotto, Lynne Uhl, Alfred DeMaria, Chester Andrzejewski
A collaboration that grew over time between local hemovigilance stakeholders and the Massachusetts Department of Public Health (MDPH) resulted in the change from a paper-based method of reporting adverse reactions and monthly transfusion activity for regulatory compliance purposes to statewide adoption of electronic reporting via the National Healthcare Safety Network (NHSN). The NHSN is a web-based surveillance system that offers the capacity to capture transfusion-related adverse events, incidents, and monthly transfusion statistics from participating facilities...
October 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27658344/transfusion-medicine-in-the-formosa-fun-coast-water-park-explosion-the-role-of-combined-tissue-and-blood-banking
#11
REVIEW
Chih-Chun Chang, Chin-Chuan Yeh, Fang-Yeh Chu
The Formosa Fun Coast explosion, occurring in a recreational water park located in the Northern Taiwan on 27 June 2015, made 499 people burn-injured. For those who had severe burn trauma, surgical intervention and fluid resuscitation were necessary, and potential blood transfusion therapy could be initiated, especially during and after broad escharotomy. Here, we reviewed the literature regarding transfusion medicine and skin grafting as well as described the practicing experience of combined tissue and blood bank in the burn disaster in Taiwan...
October 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27432635/implications-of-a-switch-to-a-100-apheresis-platelet-supply-for-patients-and-for-blood-donors-a-risk-benefit-analysis
#12
T Thiele, T Alt-Mayer, A Greinacher, J Bux
BACKGROUND: A 100% apheresis platelet supply is considered to increase transfusion safety by lowering donor exposures for transfusion recipients. We performed a risk benefit analysis to contrast the reduction of donor exposures and the risk of contaminated blood products in the nation-wide inventory with the donor risks associated with a switch to a 100% apheresis platelet supply in Germany. METHODS: Donor exposures and the number of contaminated blood products resulting from HIV-like, HBV-like, HCV-like pathogens and two theoretical agents with infection rates of 10 and 1000 in 100 000, respectively, were calculated for a 100% apheresis platelet supply in Germany based on the 2006-2012 hemovigilance reports...
November 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27429527/active-hemovigilance-significantly-improves-reporting-of-acute-non-infectious-adverse-reactions-to-blood-transfusion
#13
Naveen Agnihotri, Ajju Agnihotri
One of the key purposes of a hemovigilance program is to improve reporting of transfusion related adverse events and subsequent data-driven improvement in blood transfusion (BT) practices. We conducted a study over 3 years to assess the impact of healthcare worker training and an active feedback programme on reporting of adverse reactions to BTs. All hospitalized patients who required a BT were included in the study. Healthcare workers involved in BT to patients were sensitized and trained in adverse reaction reporting by conducting training sessions and meetings...
September 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27429521/non-infectious-complications-related-to-blood-transfusion-an-11%C3%A2-year-retrospective-analysis-in-a-tertiary-care-hospital
#14
J Philip, A Pawar, T Chatterjee, R S Mallhi, A K Biswas, U Dimri
In India transmission of transfusion transmissible infections (TTI) has shown a relative decrease as a result of mandatory screening of donated blood for TTI's. However, reducing the incidence of non infectious complications poses a major challenge, mainly due to the fact that a number of adverse reactions go unreported. Blood transfusion reaction, can be categorized based on the time interval between transfusion of blood products and the presentation of adverse reactions as acute i.e. those presenting during or within 24 h and as delayed i...
September 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27284999/clinical-pattern-in-hypotensive-transfusion-reactions
#15
Ryan A Metcalf, Sara Bakhtary, Lawrence Tim Goodnough, Jennifer Andrews
BACKGROUND: Hypotensive transfusion reactions (HyTRs) may be underreported and have been associated with patients taking angiotensin-converting enzyme inhibitors (ACEIs) receiving poststorage leukoreduced blood products through negatively charged filters. Although bedside leukoreduction is no longer commonplace, HyTRs still occur and are insufficiently characterized in the prestorage leukoreduction era. We describe recently reported cases at our institution. METHODS: We reviewed transfusion reaction records at Stanford Healthcare from January 2014 to April 2015...
August 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27232998/case-control-study-of-immediate-and-delayed-vasovagal-reactions-in-blood-donors
#16
D Narbey, A-M Fillet, S Jbilou, P Tiberghien, R Djoudi
BACKGROUND AND OBJECTIVE(S): Vasovagal reactions (VVRs) are the most common adverse events associated with blood donations. To assess the relative importance of VVR risk factors, a retrospective case-control study of severe immediate and delayed VVRs was performed. STUDY DESIGN: Vasovagal reactions were defined as immediate when occurring at the transfusion site and as delayed when occurring outside the transfusion site and within 24 h following donation. VVRs with probable or certain imputability and moderate to death severity were considered...
October 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27192594/evaluation-of-human-t-lymphotropic-virus-prevalence-co-infection-rates-for-a-four-year-period-in-a-non-metropolitan-blood-center-in-southeast-brazil
#17
Mariana Tomazini Pinto, Svetoslav Nanev Slavov, Vanderléia Bárbaro Valente, Eugênia Maria Amorim Ubiali, Dimas Tadeu Covas, Simone Kashima
INTRODUCTION: Human T-lymphotropic virus types 1/2 (HTLV-1/2) are distributed worldwide and are endemic in specific regions. METHODS: Serological evaluation of the HTLV-1/2 prevalence and co-infection rate [human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), Chagas disease, and syphilis)] for 2011-2014 was performed with volunteer blood donors from the western part of São Paulo State. RESULTS: Serrana and Araçatuba had higher HTLV seroprevalence rates (0...
April 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27146617/the-use-of-transfusion-quality-indicators-as-a-tool-for-hemovigilance-system-implementation-at-a-tertiary-care-center-in-saudi-arabia
#18
Salwa I Hindawi, Maha A Badawi, Edwin T Raj, Kholoud A Gholam, Seraj O Al-Weail, Fatima Azher
OBJECTIVES: To report 2-years experience of using transfusion-related quality indicators as a tool in hemovigilance system implementation.  METHODS: The study was carried out between 2012 and 2013. Blood transfusion service data were prospectively collected at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Donor reactions, transfusion reactions, fresh frozen plasma (FFP) in-date wastage, incidents, and errors pertaining to orders, or requests were collected quarterly and prospectively and forwarded to the Hospital Transfusion Committee (HTC) for review...
May 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27139606/serious-adverse-transfusion-reactions-reported-in-the-national-recipient-triggered-trace-back-system-in-korea-2006-2014
#19
Jeong Ran Kwon, Eun Jeong Won, Hyun Jung Jo, Sae Rom Choi, Kyoungyul Lee, Sinyoung Kim, Hyeong Sik Ahn, Young Sill Choi, Duck Cho, Dong Han Lee
BACKGROUND: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. METHODS: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation...
July 2016: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/27011671/complications-related-to-blood-donation-a-multicenter-study-of-the-prevalence-and-influencing-factors-in-voluntary-blood-donation-camps-in-karnataka-india
#20
Rajat Kumar Agarwal, Sundar Periyavan, Rakesh Dhanya, Lalith G Parmar, Amit Sedai, Kumari Ankita, Arpit Vaish, Ritesh Sharma, Prabha Gowda
INTRODUCTION: Complications associated with blood donation significantly lower odds of subsequent donations. The aim of the study is to assess the prevalence of complications related to blood donation, identify the influencing factors, and come up with suggestions for minimizing discomfort to donors and making outdoor voluntary blood donation camps safer. MATERIALS AND METHODS: This study covered 181 blood donation camps organized by Sankalp India Foundation where 16 blood banks participated from 01-04-2011 to 01-08-2014 in Karnataka...
January 2016: Asian Journal of Transfusion Science
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