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https://www.readbyqxmd.com/read/29768168/a-worm-s-gut-feelings-neuronal-muscarinic-and-epithelial-canonical-wnt-pathways-promote-antimicrobial-defense
#1
Romana R Gerner, Manuela Raffatellu
Molecular mechanisms connecting the gut-brain axis to immunity remain elusive. In this issue of Immunity, Labed et al. (2018) demonstrate that two evolutionarily conserved signaling mechanisms, the neuronal muscarinic and the epithelial Wnt pathways, together induce antimicrobial peptide expression that protects Caenorhabditis elegans against intestinal infection.
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29744350/the-gut-s-feeling-on-bile-acid-signaling-in-nafld
#2
EDITORIAL
John Y L Chiang
No abstract text is available yet for this article.
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29713909/effects-of-rifaximin-on-central-responses-to-social-stress-a-pilot-experiment
#3
Huiying Wang, Christoph Braun, Paul Enck
Probiotics that promote the gut microbiota have been reported to reduce stress responses, and improve memory and mood. Whether and how antibiotics that eliminate or inhibit pathogenic and commensal gut bacteria also affect central nervous system functions in humans is so far unknown. In a double-blinded randomized study, 16 healthy volunteers (27.00 ± 1.60 years; 9 males) received either rifaximin (600 mg/day) (a poorly absorbable antibiotic) or placebo for 7 days. Before and after the drug intervention, brain activities during rest and during a social stressor inducing feelings of exclusion (Cyberball game) were measured using magnetoencephalography...
April 30, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29684796/-they-told-me-all-mothers-have-worries-stillborn-mother-s-experiences-of-having-a-gut-instinct-that-something-is-wrong-in-pregnancy-findings-from-an-international-case-control-study
#4
Jane Warland, Alexander E P Heazell, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A Mitchell, Louise M O'Brien
OBJECTIVE: To describe and explore 'gut instinct' that something was wrong in women who identified that they experienced gut instinct during pregnancy. METHOD: A case-control study utilising an international web-based questionnaire. Stillborn cases (n = 146) and liveborn controls (n = 234) answered the gut instinct question within 30 days of the pregnancy ending. Of those, 84 cases and 27 controls also provided qualitative comment data. Descriptive statistics were used for the question, with a fixed option and summative content analysis was used to analyse the comment data...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29678923/eje-prize-2018-a-gut-feeling-about-glucagon
#5
Filip Krag Knop
Hyperglucagonaemia (in the fasting as well as in the postprandial state) is considered a core pathophysiological component of diabetes and to contribute substantially to the hyperglycaemic state of diabetes. Hyperglucagonaemia is usually viewed upon as a consequence of pancreatic alpha cell insensitivity to the glucagon-suppressive effects of glucose and insulin. Since we observed that the well-known hyperglucagonaemic response to oral glucose in patients with type 2 diabetes is exchanged by normal suppression of plasma glucagon levels following isoglycaemic intravenous glucose administration in these patients, we have been focusing on the gut and gut-derived factors as potential mediators of diabetic hyperglucagonaemia...
April 20, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29610286/immunotherapy-for-pancreatic-cancer-more-than-just-a-gut-feeling
#6
Erick Riquelme, Anirban Maitra, Florencia McAllister
<b/> Development of pancreatic cancer in spontaneous murine models is associated with enrichment of specific strains of gut and intratumoral bacteria that induce a tolerogenic immunosuppressive microenvironment favoring cancer progression and resistance to immunotherapies. Ablation of the microbiome with antibiotics reshapes the tumor microenvironment, inducing T-cell activation, improving immune surveillance, and increasing sensitivity to immunotherapy in established tumors. Cancer Discov; 8(4); 386-8...
April 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29605984/connecting-our-gut-feeling-and-how-our-gut-feels-the-role-of-well-being-attributes-in-irritable-bowel-syndrome
#7
Ashkan Farhadi, Dwaine Banton, Laurie Keefer
Background/Aims: There is a close relationship between the mind and gut in the pathogenesis of functional bowel disorders. Common psychological disturbances such as depression and anxiety are not uncommon in those with irritable bowel syndrome (IBS). There is little research investigating the role of positive psychology and gastrointestinal (GI) conditions. In this pilot study we investigated the well-being attributes in those with and without IBS. Methods: We used an anonymous online survey and recruited 416 study subjects using social media as the main method of recruitment...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29564205/from-gut-feeling-to-objectivity-machine-preservation-of-the-liver-as-a-tool-to-assess-organ-viability
#8
REVIEW
Christopher J E Watson, Ina Jochmans
Purpose of Review: The purpose of this review was to summarise how machine perfusion could contribute to viability assessment of donor livers. Recent Findings: In both hypothermic and normothermic machine perfusion, perfusate transaminase measurement has allowed pretransplant assessment of hepatocellular damage. Hypothermic perfusion permits transplantation of marginal grafts but as yet has not permitted formal viability assessment. Livers undergoing normothermic perfusion have been investigated using parameters similar to those used to evaluate the liver in vivo...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29552511/a-word-of-caution-when-uniportal-vats-should-not-be-done
#9
REVIEW
Florian Augustin, Thomas Schmid
Uniportal VATS (U-VATS) is gaining more and more popularity. Herein, we discuss the current status of adoption of the technique and-from a "laggard's" point of view-some situations when the use of U-VATS should be reconsidered. As we all do lack scientific evidence for the superiority of one minimally invasive approach over the other, these situations reflect a gut feeling rather than solid arguments. The article should raise awareness of currently discussed issues with minimally invasive approaches...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29493601/a-gut-feeling-for-cellular-fate
#10
COMMENT
Jackson Liang, Lucy Erin O'Brien
No abstract text is available yet for this article.
March 1, 2018: Nature
https://www.readbyqxmd.com/read/29490966/empathy-burn-out-and-the-use-of-gut-feeling-a-cross-sectional-survey-of-danish-general-practitioners
#11
Anette Fischer Pedersen, Mads Lind Ingeman, Peter Vedsted
OBJECTIVE: Research has suggested that physicians' gut feelings are associated with parents' concerns for the well-being of their children. Gut feeling is particularly important in diagnosis of serious low-incidence diseases in primary care. Therefore, the aim of this study was to examine whether empathy, that is, the ability to understand what another person is experiencing, relates to general practitioners' (GPs) use of gut feelings. Since empathy is associated with burn-out, we also examined whether the hypothesised influence of empathy on gut feeling use is dependent on level of burn-out...
February 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29477281/hypothalamic-sensing-of-bile-acids-a-gut-feeling
#12
Allison W Xu
Bile acids facilitate dietary fat absorption upon release into the small intestine after a meal. A recent study by Liu and colleagues identifies a gut-brain axis wherein bile acids signal an energy-replete state to hypothalamic AgRP neurons via activation of neuronal FGF receptors, which orchestrate whole-body glucose metabolism.
February 21, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29475975/resident-microbes-in-development-a-gut-feeling-for-notch
#13
(no author information available yet)
No abstract text is available yet for this article.
February 23, 2018: Development
https://www.readbyqxmd.com/read/29402235/what-gives-rise-to-clinician-gut-feeling-its-influence-on-management-decisions-and-its-prognostic-value-for-children-with-rti-in-primary-care-a-prospective-cohort-study
#14
Sophie Turnbull, Patricia J Lucas, Niamh M Redmond, Hannah Christensen, Hannah Thornton, Christie Cabral, Peter S Blair, Brendan C Delaney, Matthew Thompson, Paul Little, Tim J Peters, Alastair D Hay
BACKGROUND: The objectives were to identify 1) the clinician and child characteristics associated with; 2) clinical management decisions following from, and; 3) the prognostic value of; a clinician's 'gut feeling something is wrong' for children presenting to primary care with acute cough and respiratory tract infection (RTI). METHODS: Multicentre prospective cohort study where 518 primary care clinicians across 244 general practices in England assessed 8394 children aged ≥3 months and < 16 years for acute cough and RTI...
February 5, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29241715/engaging-patients-in-decisions-about-cancer-screening-exploring-the-decision-journey-through-the-use-of-a-patient-portal
#15
Steven H Woolf, Alex H Krist, Jennifer Elston Lafata, Resa M Jones, Rebecca R Lehman, Camille J Hochheimer, Roy T Sabo, Dominick L Frosch, Brian J Zikmund-Fisher, Daniel R Longo
INTRODUCTION: Engaging patients to make informed choices is paramount but difficult in busy practices. This study sought to engage patients outside the clinical setting to better understand how they approach cancer screening decisions, including their primary concerns and their preferences for finalizing their decision. METHODS: Twelve primary care practices offering patients an online personal health record invited eligible patients to complete a 17-item online interactive module...
February 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29217843/host-response-suppressing-gut-feelings
#16
Ashley York
No abstract text is available yet for this article.
December 8, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29204955/the-gut-feeling-breaking-down-the-role-of-gut-microbiome-in-multiple-sclerosis
#17
REVIEW
Samantha N Freedman, Shailesh K Shahi, Ashutosh K Mangalam
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system with unknown etiology. Recently, the gut microbiota has emerged as a potential factor in the development of MS, with a number of studies having shown that patients with MS exhibit gut dysbiosis. The gut microbiota helps the host remain healthy by regulating various functions, including food metabolism, energy homeostasis, maintenance of the intestinal barrier, inhibition of colonization by pathogenic organisms, and shaping of both mucosal and systemic immune responses...
January 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29165779/resilience-to-post-traumatic-stress-among-world-trade-center-survivors-a-mixed-methods-study
#18
Lisa M Gargano, Sindhushree Hosakote, Qi Zhi, Kristine A Qureshi, Robyn R Gershon
The purpose of this study was to identify individual characteristics, behaviors, and psychosocial factors associated with symptoms of post-traumatic stress disorder (PTSD) among World Trade Center (WTC) disaster evacuation survivors. The study utilized a mixed-method design. In-depth interviews were conducted using a prepared script. PTSD was assessed using the PTSD checklist-civilian (PCL-C; a score ≥ 50 indicates probable PTSD). Thematic analysis was conducted to identify factors associated with PTSD. A purposive sample of 29 WTC evacuees was recruited using a multimodal recruitment strategy...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29158344/effects-of-walking-in-water-on-gut-hormone-concentrations-and-appetite-comparison-with-walking-on-land
#19
Shin-Ya Ueda, Hidehiro Nakahara, Eriko Kawai, Tatsuya Usui, Shintaro Tsuji, Tadayoshi Miyamoto
The effects of water exercise on gut hormone concentrations and appetite currently remain unclear. The aim of the present study was to investigate the effects of treadmill walking in water on gut hormone concentrations and appetite. Thirteen men (mean ± s.d. age: 21.6 ± 2.2 years, body mass index: 22.7 ± 2.8 kg/m2 , peak oxygen uptake (VO2peak ): 49.8 ± 7.8 mL/kg per min) participated in the walking in water and on land challenge. During the study period, ratings of subjective feelings of hunger, fullness, satiety and motivation to eat were reported on a 100-mm visual analog scale...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29155372/gut-feeling-researchers-are-discovering-a-link-between-depression-and-gut-bacteria
#20
Mary Bates
The human gut is home to an abundant and diverse community of microbes–each of us carries roughly 100 trillion, representing more than 1,000 different species. The composition of one?s gut microbiota is individually specific, dynamic, and influenced by genetics, diet, age, metabolism, medication use, stress, and geography. These bacteria perform a range of necessary and beneficial functions, including breaking down our food and supporting our immune systems.
November 2017: IEEE Pulse
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