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gut feelings

Seah H Lim, Loren Fast, Alison Morris
Insights in the pathogenesis of vaso-occlusive crisis in patients with sickle cell disease have changed significantly in the last decade. Various laboratory and clinical evidence have provided support to the pivotal role of activated neutrophils in this process. A recent study in murine sickle cell disease indicated that the intestinal microbiota is responsible for regulating the number of aged neutrophils, a subset of neutrophils that are overly activated. Reduction of these neutrophils in vivo protected the mice from fatal TNFα-induced vaso-occlusive crisis...
December 1, 2016: Journal of Translational Medicine
Jacqui Wise
No abstract text is available yet for this article.
November 22, 2016: BMJ: British Medical Journal
Anne Christin Meyer-Gerspach, Simon Häfliger, Julian Meili, Alison Doody, Jens F Rehfeld, Jürgen Drewe, Christoph Beglinger, Bettina Wölnerhanssen
BACKGROUND/OBJECTIVES: Gut hormones such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) play a role as satiation factors. Strategies to enhance satiation peptide secretion could provide a therapeutic approach for obesity. Carbohydrates and lipids have been extensively investigated in relation to peptide release. In contrast, the role of proteins or amino acids is less clear. Our aim was to compare the effects of the amino acids L-tryptophan (L-trp) and L-leucine (L-leu) separately on gastric emptying and gut peptide secretion...
2016: PloS One
Christopher K Rayner, Karen L Jones, Tongzhi Wu, Michael Horowitz
No abstract text is available yet for this article.
November 9, 2016: Diabetes, Obesity & Metabolism
Anna Dart
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Cancer
Siri Lygum Voldbjerg, Mette Grønkjaer, Rick Wiechula, Erik Elgaard Sørensen
AIMS AND OBJECTIVES: To explore which knowledge sources newly graduated nurses' use in clinical decision-making and why and how they are used. BACKGROUND: In spite of an increased educational focus on skills and competencies within evidence based practice newly graduated nurses' ability to use components within evidence-based practice with a conscious and reflective use of research evidence has been described as being poor. To understand why, it is relevant to explore which other knowledge sources are used...
November 2, 2016: Journal of Clinical Nursing
Erin Dean
Identifying the best moment to move to a new job can be tricky. 'For me, it is a gut feeling,' says Teresa Chinn, a nurse and social media specialist.
September 7, 2016: Nursing Standard
Keith A Raymond
No abstract text is available yet for this article.
November 2016: Annals of Emergency Medicine
Damian Roland, Sam Jones, Tim Coats, Ffion Davies
BACKGROUND: Increasing utilisation of Emergency and Acute Care services by children and young people is a worldwide trend. This is thought to be a result of parent and carer desire for more "on demand" health care assessment and not a consequence of increasing severity of disease. A bespoke acuity assessment system in our department allowed us to test this hypothesis. METHODS: This data is based on the Paediatric Observation Priority Score, a previously published and validated assessment tool designed specifically for Paediatric Emergency Care [1]...
October 14, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Gurvinder Sahota
No abstract text is available yet for this article.
October 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Kelly R Klein, Frederick M Burkle, Raymond Swienton, Richard V King, Thomas Lehman, Carol S North
INTRODUCTION: After all large-scale disasters multiple papers are published describing the shortcomings of the triage methods utilized. This paper uses medical provider input to help describe attributes and patient characteristics that impact triage decisions. METHODS: A survey distributed electronically to medical providers with and without disaster experience. Questions asked included what disaster experiences they had, and to rank six attributes in order of importance regarding triage...
2016: PLoS Currents
Narayanan Kandasamy, Sarah N Garfinkel, Lionel Page, Ben Hardy, Hugo D Critchley, Mark Gurnell, John M Coates
Interoception is the sensing of physiological signals originating inside the body, such as hunger, pain and heart rate. People with greater sensitivity to interoceptive signals, as measured by, for example, tests of heart beat detection, perform better in laboratory studies of risky decision-making. However, there has been little field work to determine if interoceptive sensitivity contributes to success in real-world, high-stakes risk taking. Here, we report on a study in which we quantified heartbeat detection skills in a group of financial traders working on a London trading floor...
2016: Scientific Reports
Krzysztof Laudanski, Alpesh Patel
No abstract text is available yet for this article.
October 2016: Critical Care Medicine
Gé A Donker, Eva Wiersma, Lucas van der Hoek, Marianne Heins
BACKGROUND: General practitioners (GPs) use gut feelings to diagnose cancer in an early stage, but little is known about its impact. METHOD: Prospective cohort study of patients in 44 general practices throughout the Netherlands, from January 2010 until December 2013. GPs completed a questionnaire regarding gut feelings, patient and GP characteristics, if they noticed a cancer-related gut feeling during patient consultation. Follow-up questionnaires were sent 3 months later requesting information about the patient's diagnosis...
September 13, 2016: BMJ Open
Anthony J Hannan
Is that a rumbling I feel in my stomach? Or perhaps it is the trillions of bacteria down there who are in revolt, fomenting (or fermenting!) a microbial revolution? No active biologist or medical researcher can easily ignore the revolution in gut microbiome research in recent years. It seems that the gut microbiome, the entire microbial ecosystem occupying the gastrointestinal ecological niche, can impact almost every organ in the human body, not least of which being the brain. The gut microbiome has been found to signal to both the developing and adult mammalian brain, modulating both health and disease states (Cryan and Dinan, 2012; Mayer et al...
September 13, 2016: European Journal of Neuroscience
Sergueï O Fetissov
The life of all animals is dominated by alternating feelings of hunger and satiety - the main involuntary motivations for feeding-related behaviour. Gut bacteria depend fully on their host for providing the nutrients necessary for their growth. The intrinsic ability of bacteria to regulate their growth and to maintain their population within the gut suggests that gut bacteria can interfere with molecular pathways controlling energy balance in the host. The current model of appetite control is based mainly on gut-brain signalling and the animal's own needs to maintain energy homeostasis; an alternative model might also involve bacteria-host communications...
September 12, 2016: Nature Reviews. Endocrinology
Carina Remmers, Johannes Michalak
Whereas in basic research, intuition has become a topic of great interest, clinical research and depression research in specific have not applied to the topic of intuition, yet. This is astonishing because a well-known phenomenon during depression is that patients have difficulties to judge and decide. In contrast to healthy individuals who take most daily life decisions intuitively (Kahneman, 2011), depressed individuals seem to have difficulties to come to fast and adaptive decisions. The current article pursues three goals...
2016: Frontiers in Psychology
Priyadarshika Hettiarachchi, A Rajitha Wickremasinghe, Gary S Frost, Kemal I Deen, Ajith A Pathirana, Kevin G Murphy, SriLal D Jayaratne
OBJECTIVE: To assess appetite and gut hormone levels in patients following partial (PR) or total resection (TR) of the large bowel. METHODS: A comparative cross sectional study was carried out with healthy controls (n = 99) and patients who had undergone PR (n = 64) or TR (n = 12) of the large bowel. Participants consumed a standard (720 kcal) breakfast meal at 0830 (t = 0) h followed by lactulose (15 g) and a buffet lunch (t = 210 min). Participants rated the subjective feelings of hunger at t = -30, 0, 30, 60, 120, and 180 min...
August 2016: Obesity
Christine Ma-Kellams, Jennifer Lerner
Cultivating successful personal and professional relationships requires the ability to accurately infer the feelings of others-that is, to be empathically accurate. Some are better at this than others, a difference which may be explained in part by mode of thought. Specifically, empathically accurate people may tend to rely more on intuitive rather than systematic thought when perceiving others. Or it may be the reverse: systematic thought may increase empathic accuracy. To determine which view is supported by the evidence, we conducted 4 studies examining relations between mode of thought (intuitive vs...
July 21, 2016: Journal of Personality and Social Psychology
Gunnel Hänsel Petersson, Sigvard Åkerman, Per-Erik Isberg, Dan Ericson
BACKGROUND: Predicting future risk for oral diseases, treatment need and prognosis are tasks performed daily in clinical practice. A large variety of methods have been reported, ranging from clinical judgement or "gut feeling" or even patient interviewing, to complex assessments of combinations of known risk factors. In clinical practice, there is an ongoing continuous search for less complicated and more valid tools for risk assessment. There is also a lack of knowledge how different common methods relates to one another...
2016: BMC Oral Health
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