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https://www.readbyqxmd.com/read/28873387/just-a-gut-feeling-central-nervous-effects-of-peripheral-gastrointestinal-hormones
#1
Christian L Roth, Robert Patrick Doyle
Despite greater health education, obesity remains one of the greatest health challenges currently facing the world. The prevalence of obesity among children and adolescents and the rising rates of prediabetes and diabetes are of particular concern. A deep understanding of regulatory pathways and development of new anti-obesity drugs with increased efficacy and safety are of utmost necessity. The 2 major biological players in the regulation of food intake are the gut and the brain as peptides released from the gut in response to meals convey information about the energy needs to brain centers of energy homeostasis...
2017: Endocrine Development
https://www.readbyqxmd.com/read/28870194/a-yeast-fermentate-improves-gastrointestinal-discomfort-and-constipation-by-modulation-of-the-gut-microbiome-results-from-a-randomized-double-blind-placebo-controlled-pilot-trial
#2
RANDOMIZED CONTROLLED TRIAL
Iris Pinheiro, Larry Robinson, An Verhelst, Massimo Marzorati, Björn Winkens, Pieter Van den Abbeele, Sam Possemiers
BACKGROUND: Constipation and symptoms of gastrointestinal discomfort such as bloating are common among otherwise healthy individuals, but with significant impact on quality of life. Despite the recognized contribution of the gut microbiome to this pathology, little is known about which group(s) of microorganism(s) are playing a role. A previous study performed in vitro suggests that EpiCor® fermentate has prebiotic-like properties, being able to favorably modulate the composition of the gut microbiome...
September 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28836619/beyond-gut-feelings-how-the-gut-microbiota-regulates-blood-pressure
#3
REVIEW
Francine Z Marques, Charles R Mackay, David M Kaye
Hypertension is the leading risk factor for heart disease and stroke, and is estimated to cause 9.4 million deaths globally every year. The pathogenesis of hypertension is complex, but lifestyle factors such as diet are important contributors to the disease. High dietary intake of fruit and vegetables is associated with reduced blood pressure and lower cardiovascular mortality. A critical relationship between dietary intake and the composition of the gut microbiota has been described in the literature, and a growing body of evidence supports the role of the gut microbiota in the regulation of blood pressure...
August 24, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28816070/correction-to-rossi-e-et%C3%A2-al-it-s-a-gut-feeling-escherichia-coli-biofilm-formation-in-the-gastrointestinal-tract-environment
#4
(no author information available yet)
No abstract text is available yet for this article.
August 17, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28808865/glucagon-like-peptides-1-and-2-are-involved-in-satiety-modulation-after-modified-biliopancreatic-diversion-results-of-a-pilot-study
#5
Everton Cazzo, José Carlos Pareja, Elinton Adami Chaim, Cláudio Saddy Rodrigues Coy, Daniéla Oliveira Magro
BACKGROUND: This paper aimed to evaluate the influence of modified biliopancreatic diversion (BPD) on the levels of GLP-1 and GLP-2 and correlate them with satiety regulation. METHODS: This is a pilot prospective cohort study that evaluated six mildly obese individuals with type 2 diabetes mellitus, which underwent modified BPD and were followed-up for 12 months. Levels of GLP-1 and GLP-2 after a standard meal tolerance test were determined and correlated with satiety scores obtained by means of a visual analogue scale (VAS)...
August 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28736009/beliefs-of-living-donors-about-recipients-end-stage-liver-failure-and-surgery-for-organ-donation
#6
M R Krespi, A Tankurt, K Acarli, T Kanmaz, Y Yankol, M Kalayoglu
BACKGROUND: The concept of beliefs could provide a basis for how donors may perceive recipients' end-stage liver failure (ESLF) and surgery for organ donation. However, there is no such quantitative study. Therefore, the objective of this study was to explore beliefs of living donors about recipients' ESLF and surgery for organ donation. METHODS: The sample comprised 16 living donors who donated a part of their liver to a patient who had ESLF. The data were analyzed by following established procedures for inductive qualitative analysis...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28726028/should-we-all-be-scientists-re-thinking-laboratory-research-as-a-calling
#7
Louise Bezuidenhout, Nathaniel A Warne
In recent years there have been major shifts in how the role of science-and scientists-are understood. The critical examination of scientific expertise within the field of Science and Technology Studies (STS) are increasingly eroding notions of the "otherness" of scientists. It would seem to suggest that anyone can be a scientist-when provided with the appropriate training and access to data. In contrast, however, ethnographic evidence from the scientific community tells a different story. Scientists are quick to recognize that not everyone can-or should-be a scientist...
July 19, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28705224/more-than-just-a-gut-feeling-constraint-based-genome-scale-metabolic-models-for-predicting-functions-of-human-intestinal-microbes
#8
REVIEW
Kees C H van der Ark, Ruben G A van Heck, Vitor A P Martins Dos Santos, Clara Belzer, Willem M de Vos
The human gut is colonized with a myriad of microbes, with substantial interpersonal variation. This complex ecosystem is an integral part of the gastrointestinal tract and plays a major role in the maintenance of homeostasis. Its dysfunction has been correlated to a wide array of diseases, but the understanding of causal mechanisms is hampered by the limited amount of cultured microbes, poor understanding of phenotypes, and the limited knowledge about interspecies interactions. Genome-scale metabolic models (GEMs) have been used in many different fields, ranging from metabolic engineering to the prediction of interspecies interactions...
July 14, 2017: Microbiome
https://www.readbyqxmd.com/read/28704357/that-gut-feeling
#9
Anna Dart
No abstract text is available yet for this article.
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28698775/gut-feelings-on-parkinson-s-and-depression
#10
Timothy G Dinan, John F Cryan
The gut-brain axis is one of the new frontiers of neuroscience. Microbiota (the collective bacteria, viruses, fungi and other microorganisms that live in the digestive tract), sometimes referred to as the "second genome" or the "second brain," may influence our health in ways that scientists are just now beginning to understand. Scientists now believe that the microbiota and all that it involves may be a way to treat any number of disorders, including Parkinson's disease and depression.
March 2017: Cerebrum: the Dana Forum on Brain Science
https://www.readbyqxmd.com/read/28682225/-involvement-of-gut-bacteria-in-appetite-control
#11
Sergueï O Fetissov
Animals perceive alternating feelings of hunger and satiety, which constitute their daily rhythms of appetite and drive their feeding behavior. In humans, these rhythms include the onset of satiety about 20 min after meal ingestion and a duration of satiety of about 5 h followed by hunger, triggering food seeking and intake. Molecular mechanisms underlying such appetite cycles involve secretion of intestinal satiety hormones and corresponding activation of the brain anorexigenic and feeding reward pathways...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/28676773/intuitive-face-judgments-rely-on-holistic-eye-movement-pattern
#12
Laura F Mega, Kirsten G Volz
Non-verbal signals such as facial expressions are of paramount importance for social encounters. Their perception predominantly occurs without conscious awareness and is effortlessly integrated into social interactions. In other words, face perception is intuitive. Contrary to classical intuition tasks, this work investigates intuitive processes in the realm of every-day type social judgments. Two differently instructed groups of participants judged the authenticity of emotional facial expressions, while their eye movements were recorded: an 'intuitive group,' instructed to rely on their "gut feeling" for the authenticity judgments, and a 'deliberative group,' instructed to make their judgments after careful analysis of the face...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28666112/how-the-gut-feels-smells-and-talks
#13
COMMENT
Joep Beumer, Hans Clevers
Gut-brain signaling plays a central role in a range of homeostatic processes, yet details of this cross-talk remain enigmatic. In this issue of Cell, Bellono and colleagues identify a variety of luminal stimuli acting on serotonin-secreting enteroendocrine cells and, for the first time, demonstrate a functional synaptic interaction with neurons.
June 29, 2017: Cell
https://www.readbyqxmd.com/read/28577477/is-gut-feeling-by-medical-staff-better-than-validated-scores-in-estimation-of-mortality-in-a-medical-intensive-care-unit-the-prospective-feeling-on-icu-study
#14
Anne Radtke, Roman Pfister, Kathrin Kuhr, Matthias Kochanek, Guido Michels
PURPOSE: The aim of the FEELING-ON-ICU study was to compare mortality estimations of critically ill patients based on 'gut feeling' of medical staff and by Acute Physiology And Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) II and Sequential Organ Failure Assessment (SOFA). MATERIALS AND METHODS: Medical staff estimated patients' mortality risks via questionnaires. APACHE II, SAPS II and SOFA were calculated retrospectively from records...
May 25, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28549405/twelve-tips-for-the-implementation-of-epas-for-assessment-and-entrustment-decisions
#15
Harm Peters, Ylva Holzhausen, Christy Boscardin, Olle Ten Cate, H Carrie Chen
The concept of entrustable professional activities (EPAs) reframes the approach to assessment in competency-based medical education. Key to this concept is the linking of assessment to decision making about entrusting learners with clinical responsibilities. Based on recent literature and the authors' experiences with implementing EPAs, this article provides practical recommendations for how to implement EPAs for assessment and entrustment decisions in the workplace. Tips for supervising clinicians include talking to learners about trust, using EPA descriptions to guide learning and teaching, providing learners with greater ad hoc responsibilities, using EPAs to identify/create opportunities for assessment and feedback, including case-based discussions and acknowledging gut feelings about learner readiness for more autonomy...
May 26, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28521742/the-linguistic-validation-of-the-gut-feelings-questionnaire-in-three-european-languages
#16
Marie Barais, Johannes Hauswaldt, Daniel Hausmann, Slawomir Czachowski, Agnieszka Sowinska, Paul Van Royen, Erik Stolper
BACKGROUND: Physicians' clinical decision-making may be influenced by non-analytical thinking, especially when perceiving uncertainty. Incidental gut feelings in general practice have been described, namely, as "a sense of alarm" and "a sense of reassurance". A Dutch Gut Feelings Questionnaire (GFQ) was developed, validated and afterwards translated into English following a linguistic validation procedure. The aims were to translate the GFQ from English into French, German and Polish; to describe uniform elements as well as differences and difficulties in the linguistic validation processes; to propose a procedural scheme for future GFQ translations into other languages...
April 20, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28505696/-can-the-rule-of-rescue-be-rescued-a-comment-on-weyma-l%C3%A3-bbe-s-rule-of-rescue-vs-rescue-of-statistical-life
#17
Friedrich Breyer, Hartmut Kliemt
In her article "Rule of Rescue vs. Rescue of statistical lives" [1] Weyma Lübbe elevates gut feelings supporting the "rule of rescue" to "civic judgments". Without doubt in a constitutional democracy ultimately the judgments and aspirations of citizens must be decisive. Yet, particularly in the field of health policy, the bias to overemphasize what are closer rather than more remote, concrete rather than abstract consequences, should be counteracted not supported. The utility forgone by observing the "rule of rescue" in health care must be held against it...
July 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28485690/-it-s-a-gut-feeling-escherichia-coli-biofilm-formation-in-the-gastrointestinal-tract-environment
#18
Elio Rossi, Annika Cimdins, Petra Lüthje, Annelie Brauner, Åsa Sjöling, Paolo Landini, Ute Römling
Escherichia coli can commonly be found, either as a commensal, probiotic or a pathogen, in the human gastrointestinal (GI) tract. Biofilm formation and its regulation is surprisingly variable, although distinct regulatory pattern of red, dry and rough (rdar) biofilm formation arise in certain pathovars and even clones. In the GI tract, environmental conditions, signals from the host and from commensal bacteria contribute to shape E. coli biofilm formation within the multi-faceted multicellular communities in a complex and integrated fashion...
May 9, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28460928/simulated-gi-digestion-of-dietary-protein-release-of-new-bioactive-peptides-involved-in-gut-hormone-secretion
#19
Juliette Caron, Benoit Cudennec, Dorothée Domenger, Yanath Belguesmia, Christophe Flahaut, Mostafa Kouach, Jean Lesage, Jean-François Goossens, Pascal Dhulster, Rozenn Ravallec
Dietary proteins have been reported to induce a strong feeling of satiety that has been partially explained by gut hormone level increase. Up to date, various protein hydrolysates have demonstrated in vitro and in vivo their potential to stimulate gut hormone secretion related to food intake decrease and their mechanisms of action have just started to be resolved. In this context, this study aimed at identifying new peptide sequences involved in gut hormone secretion released by protein in vitro gastrointestinal digestion...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28431559/effects-of-whole-grain-rye-with-and-without-resistant-starch-type-2-supplementation-on-glucose-tolerance-gut-hormones-inflammation-and-appetite-regulation-in-an-11-14-5%C3%A2-hour-perspective-a-randomized-controlled-study-in-healthy-subjects
#20
Jonna C Sandberg, Inger M E Björck, Anne C Nilsson
BACKGROUND: The prevalence of obesity is increasing worldwide and prevention is needed. Whole grain has shown potential to lower the risk of obesity, cardiovascular disease and type 2 diabetes. One possible mechanism behind the benefits of whole grain is the gut fermentation of dietary fiber (DF), e.g. non-starch polysaccharides and resistant starch (RS), in whole grain. The purpose of the study is to investigate the effect of whole grain rye-based products on glucose- and appetite regulation...
April 21, 2017: Nutrition Journal
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