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Chronic coronary disease

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https://www.readbyqxmd.com/read/29931511/-essential-cardiac-biomarkers-in-the-differential-diagnosis-of-acute-chest-pain-an-update
#1
M Vafaie, E Giannitsis, H A Katus
Cardiac biomarkers are an integral part of the diagnostic work-up and risk stratification of patients with chest pain. Cardiac troponins are highly sensitive diagnostic biomarkers in patients with acute coronary syndrome and have prognostic value in a multitude of acute and chronic diseases. In patients with suspected pulmonary embolism (PE) D‑dimer can be used together with the Wells score for exclusion of PE. In patients with confirmed PE, B‑type natriuretic peptide (BNP), N‑terminal pro-BNP (NT-proBNP) and heart-type fatty acid binding protein (h-FABP) can be used for risk stratification...
June 21, 2018: Herz
https://www.readbyqxmd.com/read/29931040/chocolate-intake-and-heart-disease-and-stroke-in-the-women-s-health-initiative-a-prospective-analysis
#2
James A Greenberg, JoAnn E Manson, Marian L Neuhouser, Lesley Tinker, Charles Eaton, Karen C Johnson, James M Shikany
Background: Three recent meta-analyses found significant prospective inverse associations between chocolate intake and cardiovascular disease risk. Evidence from these meta-analyses suggests that such inverse associations may only apply to elderly individuals or those with pre-existing major chronic disease. Objective: We assessed the association between habitual chocolate intake and subsequent incident coronary heart disease (CHD) and stroke, and the potential effect of modification by age...
June 21, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29929787/t%C3%AE-4-increases-neovascularization-and-cardiac-function-in-chronic-myocardial-ischemia-of-normo-and-hypercholesterolemic-pigs
#3
Tilman Ziegler, Andrea Bähr, Andrea Howe, Katharina Klett, Wira Husada, Christian Weber, Karl-Ludwig Laugwitz, Christian Kupatt, Rabea Hinkel
Translations of new therapeutic options for cardiovascular disease from animal studies into a clinical setting have been hampered, in part by an improper reflection of a relevant patient population in animal models. In this study, we investigated the impact of thymosin β4 (Tβ4), which promotes collateralization and capillarization, during hypercholesterolemia, a known risk factor of coronary artery disease. Initial in vitro results highlighted an improved endothelial cell function upon Tβ4 treatment under control conditions and during hypercholesterolemic stress (scratch area [pixels]: oxidized low-density lipoprotein [oxLDL], 191,924 ± 7,717; and oxLDL + Tβ4, 105,621 ± 11,245)...
June 19, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29928990/asymmetric-dimethylarginine-adma-as-an-important-risk-factor-for-the-increased-cardiovascular-diseases-and-heart-failure-in-chronic-kidney-disease
#4
REVIEW
Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen
Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. Increased plasma ADMA and/or L-NMMA are strong and independent risk factor for chronic kidney disease, and various cardiovascular diseases such as hypertension, coronary artery disease, atherosclerosis, diabetes, and heart failure...
June 18, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29926559/-from-atherosclerosis-to-atherothrombosis-from-a-silent-chronic-pathology-to-an-acute-critical-event
#5
A J Scheen
Cardiovascular disease still represents, together with cancer, a major cause of morbidity and mortality. Atherosclerosis is a silent progressive process, which can start in early life and usually progresses with advancing age. Besides genetic predisposition, atherosclerosis is accelerated by the presence of several modifiable risk factors such as smoking, dyslipidaemia, arterial hypertension and diabetes mellitus. Asymptomatic atherosclerosis may lead to an acute event, mostly due to plaque rupture and secondary thrombosis...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29925472/impact-of-statin-ezetimibe-combination-on-coronary-atheroma-plaque-in-patients-with-and-without-chronic-kidney-disease-sub-analysis-of-precise-ivus-trial
#6
Koichiro Fujisue, Suguru Nagamatsu, Hideki Shimomura, Takuro Yamashita, Koichi Nakao, Sunao Nakamura, Masaharu Ishihara, Kunihiko Matsui, Nobuyasu Yamamoto, Shunichi Koide, Toshiyuki Matsumura, Kazuteru Fujimoto, Ryusuke Tsunoda, Yasuhiro Morikami, Koshi Matsuyama, Shuichi Oshima, Kenji Sakamoto, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa, Kenichi Tsujita
BACKGROUND: Chronic kidney disease (CKD) deteriorates the prognosis of patients undergoing percutaneous coronary intervention (PCI). Because coronary artery disease (CAD) is the major cause of death in CKD patients, cardiovascular risk reduction has been clinically important in CKD. We hypothesized intensive lipid-lowering with statin/ezetimibe attenuated coronary atherosclerotic development even in patients with CKD. METHODS: In the prospective, randomized, controlled, multicenter PRECISE-IVUS trial, 246 patients undergoing intravascular ultrasound (IVUS)-guided PCI were randomly assigned to receive atorvastatin/ezetimibe combination or atorvastatin alone (the dosage of atorvastatin was up-titrated to achieve the level of low-density lipoprotein cholesterol < 70 mg/dL)...
June 18, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29925283/the-relationship-between-circulating-testosterone-and-inflammatory-cytokines-in-men
#7
Nur-Vaizura Mohamad, Sok Kuan Wong, Wan Nuraini Wan Hasan, James Jam Jolly, Mohd Fozi Nur-Farhana, Soelaiman Ima-Nirwana, Kok-Yong Chin
Testosterone is the predominant gonadal androgen in men. Low testosterone levels are found to be associated with an increased in metabolic risk and systematic inflammation. Since adipose tissue is a source of inflammatory cytokines, testosterone may regulate inflammation by acting on adipose tissue. This review aimed to explore the role of testosterone in inflammation and its mechanism of action. Both animal studies and human studies showed that (1) testosterone deficiency was associated with an increase in pro-inflammatory cytokines; (2) testosterone substitution reduced pro-inflammatory cytokines...
June 21, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29924378/the-atherogenic-index-of-plasma-and-its-impact-on-recanalization-of-chronic-total-occlusion
#8
Jan-Erik Guelker, Alexander Bufe, Christian Blockhaus, Knut Kroeger, Thomas Rock, Ibrahim Akin, Michael Behnes, Kambis Mashayekhi
BACKGROUND: The plasma-derived atherogenic index (AIP) is associated with an increasing risk for cardiovascular diseases. Whether an increased AIP may predict the complexity of percutaneous coronary intervention (PCI) of chronic total occlusion (CTO), according to available research, has never been investigated before. METHODS: 317 patients were included prospectively and treated with PCI for at least one CTO between 2012 and 2017. High-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) plasma levels were measured 24 h before PCI...
June 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29924371/discrepancy-between-the-european-clinical-guidelines-and-myocardial-revascularization-in-patients-with-stable-coronary-artery-disease-in-russia
#9
Anton R Kiselev, Alexey S Korotin, Olga M Posnenkova, Yulia V Popova, Mikhail D Prokhorov, Vladimir I Gridnev
Objective: In European Society of Cardiology/European Association for Cardio-Thoracic Surgery (ESC/EACTS) guidelines, six indications have been proposed for making a decision on myocardial revascularization in patients with stable coronary artery disease (CAD). Our aim was to study a discrepancy between the actual clinical situation and ESC/EACTS indications on performing the revascularization in patients with CAD in Russia. Design and setting: We used retrospective clinical data on patients with stable CAD enrolled in the 2012-2015 Russian Registry of Hypertension, Coronary Artery Disease, and Chronic Heart Failure...
June 19, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29923067/hypertensive-disorders-of-pregnancy-and-cardiovascular-diseases-current-knowledge-and-future-directions
#10
REVIEW
Thais Coutinho, Olabimpe Lamai, Kara Nerenberg
PURPOSE OF THE REVIEW: Cardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk. RECENT FINDINGS: Robust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to women with normotensive pregnancies...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29922510/is-right-coronary-artery-chronic-total-vessel-occlusion-impacting-the-surgical-revascularization-results-of-patients-with-multivessel-disease-a-retrospective-study
#11
Janusz Konstanty-Kalandyk, Krzysztof Bartuś, Jacek Piątek, Anna Kędziora, Tomasz Darocha, Krzysztof L Bryniarski, Marcin Wróżek, Piotr Ceranowicz, Stanisław Bartuś, Leszek Bryniarski, Bogusław Kapelak
Introduction: Chronic total occlusion (CTO) is common in the presence of other significantly narrowed coronary arteries. The impact of total occlusion and its association with completeness of revascularization on patients with multivessel disease undergoing coronary artery bypass graft (CABG) remains largely unknown. Aim: The aim of our study was to compare CABG operation characteristics, as well as 30-day mortality, incidence of post-operative major adverse cardiac and cerebrovascular events (MACCE) between patients with and without CTO in right coronary artery (RCA)...
2018: PeerJ
https://www.readbyqxmd.com/read/29920397/unusual-clinical-sequalae-of-kawasaki-disease-symptomatic-extracranial-internal-carotid-stenosis-in-young-adult-a-case-report
#12
Shigeomi Yokoya, Aiko Tamura, Akihiko Hino, Masamichi Bamba, Toshikazu Kato, Hidesato Takezawa, Yukihiro Goto, Hideki Oka, Akihiro Fujii
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects the coronary artery, but does not commonly affect the carotid artery. Cerebral infarction (CI) with internal carotid artery stenosis (ICS) in patients with KD had never been reported. We report a patient with CI as a remote phase complication of KD. CASE PRESENTATION: A 32-year-old man presented with impaired consciousness. Magnetic resonance imaging scan (MRI) and digital subtraction angiogram (DSA) confirmed CI and ICS...
June 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29915884/drug-coated-balloon-angioplasty-for-de-novo-small-vessel-disease-including-chronic-total-occlusion-and-bifurcation-in-real-world-clinical-practice
#13
Takayuki Onishi, Yuko Onishi, Isshi Kobayashi, Shigeo Umezawa, Akihiro Niwa
The aim of this study is to validate the efficacy of drug-coated balloons (DCBs) for real-world de novo small vessel diseases including chronic total occlusion and bifurcation. DCB angioplasty has been reported to be effective in the treatment of de novo small vessel disease. However, the number of reports that have focused on complex lesions is limited. This observational study comprised consecutive patients who underwent DCB angioplasty for de novo small vessel disease with a reference diameter of less than 2...
June 18, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29915101/proteomic-architecture-of-human-coronary-and-aortic-atherosclerosis
#14
David M Herrington, Chunhong Mao, Sarah J Parker, Zongming Fu, Guoqiang Yu, Lulu Chen, Vidya Venkatraman, Yi Fu, Yizhi Wang, Timothy D Howard, Goo Jun, Caroline F Zhao, Yongmei Liu, Georgia Saylor, Weston R Spivia, Grace B Athas, Dana Troxclair, James E Hixson, Richard S Vander Heide, Yue Wang, Jennifer E Van Eyk
BACKGOUND: The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets. METHODS: Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens)...
June 19, 2018: Circulation
https://www.readbyqxmd.com/read/29911119/the-association-between-nfkb1-94attg-ins-del-and-nfkb1a-826c-t-genetic-variations-and-coronary-artery-disease-risk
#15
Abbas Seidi, Sina Mirzaahmadi, Khalil Mahmoodi, Mohammad Soleiman-Soltanpour
Coronary artery disease (CAD) is considered as a chronic inflammatory disease initiated from early childhood. Nuclear factor κB (NF κB) and κB1A (NF κB1A) are the key regulators of inflammatory responses. The NFKB1 -94ATTG ins/del and NFKB1A -826C/T polymorphisms may contribute to the development of CAD. The aim of the present study was to investigate the association of these polymorphisms with the risk of CAD. The study population included 120 patients with angiographically confirmed CAD and 100 matched controls...
March 2018: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/29909107/comparative-utilization-and-temporal-trends-in-cardiac-stress-testing-in-u-s-medicare-beneficiaries-with-and-without-chronic-kidney-disease
#16
Charles A Herzog, Tanya Natwick, Shuling Li, David M Charytan
OBJECTIVES: The authors aimed to analyze temporal trends in cardiac stress testing in U.S. Medicare beneficiaries from 2008 to 2012, types of stress testing, and comparative utilization related to the presence and severity of chronic kidney disease (CKD). BACKGROUND: A long-held perception depicts patients with CKD as being treated less intensively for cardiovascular disease than nonrenal patients. We wondered whether use of diagnostic testing for ischemic heart disease is affected by the presence of CKD...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29907655/causes-and-predictors-of-readmission-in-patients-with-atrial-fibrillation-undergoing-catheter-ablation-a-national-population-based-cohort-study
#17
Shilpkumar Arora, Sopan Lahewala, Byomesh Tripathi, Varshil Mehta, Varun Kumar, Divya Chandramohan, Alejandro Lemor, Mihir Dave, Nileshkumar Patel, Nilay V Patel, Ghanshyam Palamaner Subash Shantha, Juan Viles-Gonzalez, Abhishek Deshmukh
BACKGROUND: Reducing readmission after catheter ablation (CA) in atrial fibrillation (AF) is important. METHODS AND RESULTS: We utilized National Readmission Data (NRD) 2010-2014. AF was identified by International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) diagnostic code 427.31 in the primary field, while first CA of AF was identified via ICD-9 -procedure code 37.34. Any admission within 30 or 90 days of index admission was considered a readmission...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907132/association-between-multiple-comorbidities-and-self-rated-health-status-in-middle-aged-and-elderly-chinese-the-china-kadoorie-biobank-study
#18
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29902166/obesity-prevalence-among-adults-living-in-metropolitan-and-nonmetropolitan-counties-united-states-2016
#19
Elizabeth A Lundeen, Sohyun Park, Liping Pan, Terry O'Toole, Kevin Matthews, Heidi M Blanck
Approximately 46 million persons (14%) in the United States live in nonmetropolitan counties.* Compared with metropolitan residents, nonmetropolitan residents have a higher prevalence of obesity-associated chronic diseases such as diabetes (1), coronary heart disease (1), and arthritis (2). The 2005-2008 National Health and Nutrition Examination Survey (NHANES) found a significantly higher obesity prevalence among adults in nonmetropolitan (39.6%) than in metropolitan (33.4%) counties (3). However, this difference has not been examined by state...
June 15, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29901810/on-x-mitral-valve-replacement-a-single-centre-experience-in-318-patients
#20
Giacomo Murana, Jacopo Alfonsi, Carlo Savini, Carlo Mariani, Giuditta Coppola, Valeria Lo Coco, Emanuele Pilato, Davide Pacini, Roberto Di Bartolomeo
OBJECTIVES: If mitral valve repair is not feasible, mitral valve replacement remains the only option. Based on our overall experience with the On-X mitral valve, the aim of this study was to investigate early and late outcomes after mitral valve replacement using this latest generation prosthesis. METHODS: From 1998 to 2016, 600 patients received an On-X prosthesis in the mitral position. Of them, we excluded all patients who had combined aortic procedures and retrospectively analysed 318 consecutive patients who had a mitral valve replacement...
June 12, 2018: Interactive Cardiovascular and Thoracic Surgery
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