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Stable coronary aterial disease

Yun-Sheng Yu, Zhen-Ya Shen, Wen-Xue Ye, Hao-Yue Huang, Fei Hua, Yi-Huan Chen, Ke Chen, Wei-Jie Lao, Li Tao
BACKGROUND: Transplantation of adult bone marrow-derived mesenchymal stem cells (MSCs) has been proposed as a strategy for cardiac repair following myocardial damage. However cell transplantation strategies to replace lost myocardium are limited by the inability to deliver large numbers of cells that resist peritransplantation graft cell death. Accordingly, we set out to isolate and expand adult swine bone marrow-derived MSCs, and to engineer these cells to overexpress AKT1 (protein kinase B), to test the hypothesis that AKT1-engineered MSCs are more resistant to apoptosis and can enhance cardiac repair after transplantation into the ischemic swine heart...
July 2010: Chinese Medical Journal
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