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https://www.readbyqxmd.com/read/29348282/acquired-pyloric-stenosis-resulting-in-hypokalaemic-hyperchloraemic-normal-anion-gap-metabolic-acidosis-persistent-vomiting-in-an-adult-cause-and-effect
#1
Philip Kaye
A 24-year-old woman presented with a history of persistent vomiting for at least 3 months. This resulted in severe dehydration with risk of acute kidney injury. In addition to volume depletion, loss of gastric fluid resulted in a specific metabolic derangement-hypokalaemic, hypochloraemic normal anion gap metabolic alkalosis with a reduced ionised calcium concentration and paradoxical aciduria. These metabolic changes were reflected in her ECG. Investigation demonstrated acquired gastric outflow tract obstruction secondary to a pyloric peptic ulcer...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29348096/antiulcer-activity-of-methanol-chloroform-extract-of-channa-striatus-fillet
#2
Ahmad Khusairi Azemi, Mohd Hafiz Abd Rahim, Siti Syariah Mamat, Abdul Manan Mat Jais, Zainul Amiruddin Zakaria
Channa striatus (Haruan) is Malaysian freshwater fish that is traditionally used to treat ailments related to wound and also ulcers. The aimed of the present study was to determine the mechanisms of anti-ulcer activity of chloroform: methanol extract of C. striatus fillet (CMCS) in rats. The antiulcer profile of CMCS, given orally in the doses of 50, 250 and 500mg/kg, was assessed using the ethanol- and indomethacin-induced gastric ulcer models. The mechanisms of antiulcer of CMCS were determined as follows; i) the antisecretory activity of CMCS was measured using the pyloric ligation rat model, and; ii) the role of nitric oxide (NO) and sulfhydryl compounds in the modulation of CMCS antiulcer activity were determined by pre-treating the rats with L-NAME or NEM, respectively, followed by the pre-treatment of rats with CMCS before subjecting the animals to the ethanol-induced gastric ulcer model...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29340829/trends-and-surgical-outcomes-of-laparoscopic-versus-open-pyloromyotomy
#3
William C Kethman, Alex H S Harris, Mary T Hawn, James K Wall
BACKGROUND: Hypertrophic pyloric stenosis (HPS) is one of the most common pediatric illnesses necessitating surgical intervention. Controversy remains over the optimal surgical approach between laparoscopic pyloromyotomy (LP) and open pyloromyotomy (OP). LP has gained acceptance for management of HPS in an era of expanding minimal access surgical approaches to pediatric conditions. Several studies suggest advantages of LP over OP; however, selection bias and small sample sizes remain a concern...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29338765/infantile-hypertrophic-pyloric-stenosis-a-4-year-experience-from-two-tertiary-care-centres-in-cameroon
#4
Rene Ndongo, Paul Nkemtendong Tolefac, Faustin Félicien Mouafo Tambo, Matin Hongieh Abanda, Marcelin Ngowe Ngowe, Olivier Fola, Bonaventure Dzekem, Patrick Eroyl Weledji, Maurice Aurelien Sosso, Jacqueline Ze Minkande
OBJECTIVE: This study aimed to describe the clinical characteristics of patients with infantile hypertrophic stenosis, management and its outcome in two tertiary care centres in Cameroon. RESULTS: A total of 21 patients were included from the two centres. The mean age at presentation was 5.2 ± 1.2 weeks, predominantly male with a male-to-female ratio of 4.25:1. The triad of vomiting, visible peristalsis and palpable mass was present in only 7 (33.3%) of the participants...
January 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29337669/gastroprotective-effects-of-the-isopropanol-extract-of-artemisia-princeps-and-its-gastroretentive-floating-tablets-on-gastric-mucosal-injury
#5
Joo-Il Kim, Sang-Wook Park, Jhong-Jae Lim, Se-Il Sohn, Ji-Su Shin, Sang Cheol Park, Young Pyo Jang, Eun Kyoung Chung, Hong-Woo Lee, Kyung-Tae Lee
In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29312838/pyloric-gland-metaplasia-of-the-ileocecal-valve-clinicopathologic-correlates-of-inflammatory-bowel-disease
#6
Daryl Ramai, Kinesh Changela, Madhavi Reddy
Pyloric gland metaplasia of the ileocecal valve, in the setting of Crohn's disease, is an unusual clinical entity. Though its etiology and pathogenesis remains unclear, metaplastic changes have been associated with chronic inflammation and inflammatory bowel disease. Herein, we report a case of a 23-year-old male who presented for surveillance colonoscopy after being diagnosed with Crohn's disease four years ago. Diagnostic colonoscopy revealed stenosis of the ileocecal valve as well as a 5 mm polypoid circumferential non-obstructing lesion...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29278427/gastric-pyloric-gland-adenoma-a-multicenter-clinicopathologic-study-of-67-cases
#7
Won-Tak Choi, Ian Brown, Tetsuo Ushiku, Masato Yozu, Namrata Setia, Amitabh Srivastava, Melanie Johncilla, Rish K Pai, Ryan M Gill, Masashi Fukayama, Joseph Misdraji, Gregory Y Lauwers
AIMS: There is limited information regarding the clinicopathologic and immunohistochemical characteristics of gastric pyloric gland adenomas (PGAs). METHODS AND RESULTS: Sixty seven cases of gastric PGA from 57 patients were analyzed. PGAs occurred with similar frequency in men and women (47.4% and 52.6%, respectively) with a mean age of 66 years. Most presented in the gastric body/fundus (67.2%). Fifteen cases (22.4%) developed in a background of autoimmune gastritis (AIG), whereas normal mucosa was seen in 35...
December 26, 2017: Histopathology
https://www.readbyqxmd.com/read/29260144/pneumatosis-cystoides-intestinalis-a-rare-cause-of-intraabdominal-free-air
#8
Hüseyin Pülat, Girayhan Çelik, Mehmet Zafer Sabuncuoğlu, Mehmet Fatih Benzin, Oktay Karaköse, Recep Çetin
Pneumatosis cystoides intestinalis is a rarely seen disease characterized by cysts filled with multiple gases in the wall of the small or large intestine. Many factors have been suggested in the etiology and pathogenesis, including peptic ulcer, pyloric stenosis, and endoscopic trauma. Because various clinical characteristics and symptoms are observed together, diagnosis is generally difficult. It may be a cause of free air observed on direct radiographs. Treatment is directed at the cause and although there is generally a good course, it can sometimes lead to severe complications...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29238893/postprandial-cardiogenic-syncope-caused-by-gastric-polyp-induced-pyloric-obstruction-in-an-elderly-woman-with-a-giant-hiatal-hernia-a-case-report
#9
Hideyuki Saito, Tatsuya Miyazaki, Makoto Sohda, Makoto Sakai, Hiroaki Honjyo, Yuuji Kumakura, Tomonori Yoshida, Takehiko Yokobori, Koji Kurosawa, Hiroyuki Kuwano
BACKGROUND: Hiatal hernias are common. In some reports, hiatal hernias have been implicated in causing dyspnea, syncope, and heart failure. CASE PRESENTATION: An 82-year-old woman with a hiatal hernia was admitted to our hospital because she had experienced postprandial syncope during the last few years. Esophagogastroduodenoscopy revealed a large hiatal hernia and a pedunculated polyp of the stomach antrum that fit into the pylorus. An upper gastrointestinal contrast study showed that the entire stomach had relocated to the thoracic cavity and that the body of the stomach was located above the fundus, resulting in a so-called upside-down stomach...
December 13, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29236729/genome-wide-analysis-of-atlantic-salmon-salmo-salar-mucin-genes-and-their-role-as-biomarkers
#10
Lene Rydal Sveen, Fabian Thomas Grammes, Elisabeth Ytteborg, Harald Takle, Sven Martin Jørgensen
The aim of this study was to identify potential mucin genes in the Atlantic salmon genome and evaluate tissue-specific distribution and transcriptional regulation in response to aquaculture-relevant stress conditions in post-smolts. Seven secreted gel-forming mucin genes were identified based on several layers of evidence; annotation, transcription, phylogeny and domain structure. Two genes were annotated as muc2 and five genes as muc5. The muc2 genes were predominantly transcribed in the intestinal region while the different genes in the muc5 family were mainly transcribed in either skin, gill or pyloric caeca...
2017: PloS One
https://www.readbyqxmd.com/read/29236645/caterpillar-sign-in-infantile-hypertrophic-pyloric-stenosis
#11
Bruno Martinez-Leo, Luis M Garcia-Cabello
A 23-day-old male infant was brought to the emergency department because of nonbilious vomiting that had increased in frequency over a period of 5 days. Findings from the clinical examination were notable for mild dehydration and a possible olive-sized mass, approximately 2 cm in diameter, that was..
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29236590/a-novel-nonelectrosurgical-technique-for-incising-the-pylorus-in-laparoscopic-pyloromyotomy
#12
Ziad A Bataineh, Nathan M Novotny
OBJECTIVE: Since the loss of the protected arthrotomy knife several years ago, pediatric surgeons have struggled to find a safe, reliable, and inexpensive way to incise the pyloric serosa before spreading the muscle. The most widely accepted method of cutting the serosa is with electrocautery, although some still question its safety. We introduce a novel technique of incising the serosa with a percutaneously inserted needle without the use of electrocautery. DESCRIPTION: In this case series, we describe the experience of a single surgeon with a novel technique of incising the serosa...
December 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29233547/the-developing-spectrum-of-gastric-type-cervical-glandular-lesions
#13
REVIEW
Karen L Talia, W Glenn McCluggage
Adenocarcinoma of the cervix is less common than squamous cell carcinoma, although its relative prevalence is increasing. Oncogenic (high-risk) human papillomavirus (HPV) infection is implicated in the development of approximately 90% of all cervical adenocarcinomas. Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. Minimal deviation adenocarcinoma (MDA) of mucinous type (adenoma malignum) is considered an extremely well differentiated variant of GAS and is encompassed within the category of GAS...
December 9, 2017: Pathology
https://www.readbyqxmd.com/read/29221284/comparison-of-perioperative-outcomes-following-hybrid-minimally-invasive-versus-open-ivor-lewis-esophagectomy-for-esophageal-cancer
#14
Ju Sik Yun, Kook Joo Na, Sang Yun Song, Seok Kim, In Seok Jeong, Sang Gi Oh
Background: The outcomes of various minimally invasive esophagectomy (MIE) procedures for esophageal cancer have been reported; however, those of the hybrid approach are lacking. This study aimed to assess the impacts of hybrid minimally invasive Ivor Lewis esophagectomy (HIL, laparoscopy and right thoracotomy) for esophageal cancer on perioperative outcomes compared with the open approach. Methods: This was a retrospective study of 153 patients who underwent Ivor Lewis esophagectomy for squamous cell carcinoma between January 2008 and December 2016...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29198538/a-nonlethal-case-of-junctional-epidermolysis-bullosa-and-congenital-pyloric-atresia-compound-heterozygosity-in-a-patient-with-a-novel-integrin-beta-4-gene-mutation
#15
Lauren Ko, Cornelia L Griggs, Konstantinos S Mylonas, Peter T Masiakos, Daniela Kroshinsky
We report a case of nonfatal junctional epidermolysis bullosa and pyloric atresia in a newborn. We identified a substitution (c.914C>T) for the integrin β4 gene that has been associated with favorable outcome. A novel mutation (c.2011T>G) of unknown significance was also found in this patient who is now thriving.
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29188801/pharmacokinetic-and-pharmacodynamic-evidence-for-developing-an-oral-formulation-of-octreotide-against-gastric-mucosal-injury
#16
Xi-Nuo Li, Tai Rao, Yang-Fan Xu, Kang-Rui Hu, Zhang-Pei Zhu, Hao-Feng Li, Dian Kang, Yu-Hao Shao, Bo-Yu Shen, Xiao-Xi Yin, Lin Xie, Guang-Ji Wang, Yan Liang
Among the somatostatin analogues, octreotide (OCT) is the most commonly used in clinic via intravenous or subcutaneous injection to treat various diseases caused by increased secretion of growth hormone, gastrin or insulin. In order to assesse the feasibility of developing oral formulations of OCT, we conducted systematical pharmacokinetic and pharmacodynamic analyses of OCT in several animal models. The pharmacokinetic studies in rats showed that intragastric administration of OCT had extremely low bioavailability (<0...
November 30, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29183135/-a-rare-case-of-gastric-outlet-syndrome-internal-incarceration-after-removal-of-gastric-banding
#17
Pál Ondrejka, Ferenc Siket, Mária Bakos, Márta Vámos, András Novák, István Sugár
The laparoscopically administrated adjustable gastric banding used to be widely practiced as treatment of extreme obesity. As lots of complaints and complications arose sooner or later after this procedure, they had to be removed quite often. Half year after such a removal we observed a 37-year-old female patient with complete gastric outlet obstruction. The patient was operated and cured completely. The cause of gastric obstruction was an internal incarceration of the pyloric region between the plication made at the time of the ring removal and the gastric body...
December 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/29174961/effect-of-premedication-with-butorphanol-or-methadone-on-ease-of-endoscopic-duodenal-intubation-in-dogs
#18
William Jm McFadzean, Edward J Hall, Hugo van Oostrom
OBJECTIVE: The effect of premedication with butorphanol or methadone on ease of endoscopic duodenal intubation. STUDY DESIGN: Prospective, randomized, blinded clinical trial. ANIMALS: A group of 20 client-owned dogs. METHODS: Dogs were assigned randomly to be administered intravenous (IV) premedication with either butorphanol (0.4 mg kg-1) or methadone (0.3 mg kg-1). General anaesthesia was induced with propofol to effect and maintained with isoflurane in 100% oxygen...
June 7, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29167219/ingestion-of-nine-metallic-nails-with-corrosive-what-happened-next
#19
Manu Vats, Sadhasivam Ramasamy, Sushanto Neogi, Sanjeev Kumar Tudu
A 20-year-old woman was brought to the surgery emergency department with the complaint of epigastric pain since 1 day following ingestion of multiple metallic nails with a cup full of toilet cleaner (corrosive acid) with a suicidal intention. Physical examination was essentially unremarkable, and the abdomen showed no signs of perforation peritonitis. X-rays of the abdomen showed multiple 'nail'-like radiopaque shadows in the abdominal cavity with no evidence of free gas under the domes of the diaphragm. A non-operative expectant management was pursued...
November 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29157882/current-perioperative-care-of-infants-with-pyloric-stenosis-comparison-of-survey-results
#20
Richard S Cartabuke, Joseph D Tobias, Julie Rice, Dmitry Tumin
BACKGROUND: Considerable variation in the perioperative management of infants with pyloric stenosis (PS) led the authors to undertake a survey of pediatric anesthesiologists to determine if consensus-based guidelines could be developed. MATERIALS AND METHODS: Physicians who are members of the Society for Pediatric Anesthesia or the Association of Pediatric Anaesthetists of Great Britain and Ireland completed an online questionnaire through SurveyMonkey regarding current management of patients with PS...
November 17, 2017: Journal of Surgical Research
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