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https://www.readbyqxmd.com/read/28943298/cloning-and-functional-characterization-of-fads2-desaturase-and-elovl5-elongase-from-japanese-flounder-paralichthys-olivaceus
#1
Naoki Kabeya, Mizumo Chiba, Yutaka Haga, Shuichi Satoh, Goro Yoshizaki
Japanese flounder Paralichthys olivaceus has an essential requirement for long-chain polyunsaturated fatty acids (LC-PUFA), particularly docosahexaenoic acid and eicosapentaenoic acid, but the enzymes involved in LC-PUFA biosynthesis are thought to be absent or to have low activity. Teleost fish, in particular, have quite diversified substrate preference of these enzymes even among closely related species, implying that each species could have different LC-PUFA biosynthetic capabilities. Therefore, in the present study, we characterized Japanese flounder fatty acid desaturase 2 (Fads2) and elongation of very long-chain fatty acids protein 5 (Elovl5) in order to precisely characterize the LC-PUFA biosynthesis pathway...
September 21, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28928620/consideration-of-pyloric-stenosis-as-a-cause-of-feeding-dysfunction-in-children-with-cyanotic-heart-disease
#2
Nayan T Srivastava, John J Parent, Marcus S Schamberger
Feeding difficulty has been reported at a higher incidence in infants with cyanotic heart disease and single ventricle physiology necessitating specialized feeding strategies. However, structural causes of feed intolerance in this subset of patients should not be ignored. This case series highlights three recent cases of pyloric stenosis in infants with left-sided obstructive lesions at our institution. In all three cases, the initial presumed diagnosis was feeding intolerance related to heart disease, and there was significant clinical improvement following identification and correction of pyloric stenosis...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28927980/william-ladd-before-the-halifax-explosion
#3
REVIEW
Don K Nakayama
Legend holds that treating the hundreds of children injured in the Halifax explosion of December 6, 1917, compelled Dr. William E. Ladd (1880-1967) to dedicate his career to the surgical care of infants and children. However, he had made the commitment to be a pediatric surgeon several years before when he joined the voluntary staff of the Children's Hospital of Boston in 1910. In the years before Halifax, he was among the vanguard of American surgeons who brought the mortality of intussusception to 45% from 90%, and of pyloric stenosis to 15% from 60%...
September 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28912412/-a-case-of-advanced-neuroendocrine-cell-carcinoma-of-the-stomach-treated-with-s-1-and-cisplatin-chemotherapy
#4
Mikiko Sakuraya, Yoshimasa Shimizu, Nobuo Tachikawa, Hitoshi Hara, Masaki Ohashi, Tomoo Shatari, Masao Hori
A 69-year-old man presented to our hospital because of epigastric pain. A type 2 lesion was seen in the lesser curvature of the antrum of the stomach. A moderately differentiated adenocarcinoma(human epidermal growth factor receptor 2-negative) was diagnosed by biopsy. Abdominal computed tomography showed a mass shadow 52mm in diameter in the pyloric region invading the surrounding organs, but no evidence of distant metastasis. Chemotherapy with S-1 and cisplatin(SP therapy)was initiated because of a diagnosis of locally advanced gastric cancer...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28901937/advances-in-paediatric-gastroenterology
#5
REVIEW
Paul K H Tam, Patrick H Y Chung, Shawn D St Peter, Christopher P Gayer, Henri R Ford, Greta C H Tam, Kenneth K Y Wong, Mikko P Pakarinen, Mark Davenport
Recent developments in paediatric gastrointestinal surgery have focused on minimally invasive surgery, the accumulation of high-quality clinical evidence, and scientific research. The benefits of minimally invasive surgery for common disorders like appendicitis and hypertrophic pyloric stenosis are all supported by good clinical evidence. Although minimally invasive surgery has been extended to neonatal surgery, it is difficult to establish its role for neonatal disorders such as oesophageal atresia and biliary atresia through clinical trials because of the rarity of these disorders...
September 9, 2017: Lancet
https://www.readbyqxmd.com/read/28899644/transcriptomics-reveals-tissue-organ-specific-differences-in-gene-expression-in-the-starfish-patiria-pectinifera
#6
Chan-Hee Kim, Hye-Jin Go, Hye Young Oh, Yong Hun Jo, Maurice R Elphick, Nam Gyu Park
Starfish (Phylum Echinodermata) are of interest from an evolutionary perspective because as deuterostomian invertebrates they occupy an "intermediate" phylogenetic position with respect to chordates (e.g. vertebrates) and protostomian invertebrates (e.g. Drosophila). Furthermore, starfish are model organisms for research on fertilization, embryonic development, innate immunity and tissue regeneration. However, large-scale molecular data for starfish tissues/organs are limited. To provide a comprehensive genetic resource for the starfish Patiria pectinifera, we report de novo transcriptome assemblies and global gene expression analysis for six P...
September 9, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28898918/insertion-of-percutaneous-endoscopic-gastrostomy-tubes-with-jejunal-extensions-using-the-wedge-technique-a-novel-method-to-prevent-retrograde-tube-migration-into-the-stomach
#7
Michael S L Sey, Hannah Gregor, Jamie Gregor, Brian Yan
Background and study aim In percutaneous endoscopic gastrostomy (PEG) with jejunal extension (PEGJ) procedures, retrograde migration of the jejunal extension tube into the stomach during endoscope withdrawal is a frustrating problem. We describe the novel "wedge" technique for inserting the jejunal extension tube, utilizing single-balloon enteroscopy to anchor it in place. Patients and methods Prospective 1-year study of consecutive patients undergoing PEGJ insertion at a single tertiary care center. The primary outcome was number of pyloric intubations required to place the jejunal extension tube...
September 12, 2017: Endoscopy
https://www.readbyqxmd.com/read/28885510/pylorus-resection-does-not-reduce-delayed-gastric-emptying-after-partial-pancreatoduodenectomy-a-blinded-randomized-controlled-trial-propp-study-drks00004191
#8
Thilo Hackert, Pascal Probst, Phillip Knebel, Colette Doerr-Harim, Thomas Bruckner, Ulla Klaiber, Jens Werner, Lutz Schneider, Christoph W Michalski, Oliver Strobel, Alexis Ulrich, Markus K Diener, Markus W Büchler
OBJECTIVES: The aim of this study was to investigate the effect of pylorus resection on postoperative delayed gastric emptying (DGE) after partial pancreatoduodenectomy (PD). BACKGROUND: PD is the standard treatment for tumors of the pancreatic head. Preservation of the pylorus has been widely accepted as standard procedure. DGE is a common complication causing impaired oral intake, prolonged hospital stay, and postponed further treatment. Recently, pylorus resection has been shown to reduce DGE...
September 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28876587/is-routine-staging-laparoscopy-in-potentially-resectable-disease-justified-in-gastric-cancer-a-single-unit-experience
#9
G Chinnery, J Plaskett, E Jonas
BACKGROUND: Gastric adenocarcinoma is a heterogenous disease with often a late presentation. Staging laparoscopy (SL) improves the detection of metastases not visible on standard cross-sectional imaging. Routine SL may avoid unnecessary surgical exploration in a significant proportion of patients. METHOD: A retrospective review of a prospectively maintained database was performed identifying the use of routine SL in patients presenting with potentially resectable gastric (GCA) and oesophagogastric junction (OGJ) adenocarcinoma; with patients presenting between April 2013 and April 2017 to a single surgical unit reviewed...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876575/neonatal-surgery-a-study-of-two-years-at-nelson-mandela-academic-hospital-mthatha-eastern-cape
#10
A Delgado, A Cejas, D Bangasa
BACKGROUND: Advances in diagnostic techniques and perioperative care have greatly improved the outcome of neonatal surgery. Despite this, disparity still exists in the outcome of neonatal surgery between developed and developing countries. METHOD: We performed a prospective study of neonates admitted and treated due to surgical congenital diseases and other conditions in our hospital from April 2015 to April 2017. RESULTS: There were 19 (28,7%) females and 47 (70,3%) males in this group...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28868226/recurrent-gastric-ulcer-and-cholangitis-caused-by-ectopic-drainage-of-the-bile-duct-into-the-stomach
#11
Katrin Bauer, Christof Keller
We report a case of recurrent gastritis with pyloric stenosis and cholangitis due to a rare variation in bile duct anatomy. A 72-year-old female patient showed recurrent gastral ulcers and biliary colic with cholangitis caused by gallstones in the main bile duct with an ectopic orifice in the prepyloric region and concurrent inflammatory pyloric stenosis. After temporarily successful endoscopic treatment with stenting and pyloric dilatation, the patient suffered from recurrent cholangitis. Finally, the abnormal biliary anatomy required surgical treatment with biliodigestive anastomosis...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/28842652/application-of-color-doppler-ultrasound-combined-with-doppler-imaging-artifacts-in-the-diagnosis-and-estimate-of-congenital-hypertrophic-pyloric-stenosis
#12
Suihong Ma, Jianhua Liu, Youxiang Zhang, Yuwen Yang, Hai Jin, Xiaomei Ma, Hongqin Wei
Congenital Hypertrophic Pyloric Stenosis (CHPS) is a disease condition that is caused as a result of pylorus wall hypertrophy and hyperplasia. In this study, we used color Doppler flow imaging (CDFI) and Doppler artifacts technique to observe the blood flow of hypertrophic pylorus tissue and the dynamic imaging of liquid passing through the pyloric canal in CHPS infants. 65 cases of CHPS infants and 50 infants without CHPS served as control group. We found that there were statistically significant differences between the blood flow grade of muscular layer and mucosal layer between CHPS and control infants, but no significant differences were observed in the same group...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28836242/-discussion-on-standardized-implementation-of-laparoscopic-radical-lymphadenectomy-for-distal-gastric-cancer
#13
Zejian Lyu, Junjiang Wang, Yong Li
Laparoscopic radical gastrectomy for gastric cancer has been widely applied in clinical practice, and its indications have been extended from early gastric cancer to advanced gastric cancer. It is acknowledged that laparoscopic radical gastrectomy is technically challenging because of the complexity of anatomy, rich blood supply, and extensive lymph node dissection. This paper primarily intends to share the experience of laparoscopic radical D2 gastrectomy for distal gastric cancer with details of choosing the location of Trocar, surgical approaches and the sequence of lymph node dissection...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28832359/functional-dyspepsia-and-gastroparesis
#14
Jan Tack, Florencia Carbone
PURPOSE OF REVIEW: This review summarizes recent progress in the epidemiology, pathophysiology and treatment of functional dyspepsia and gastroparesis. RECENT FINDINGS: The definition of functional dyspepsia and its subgroups has been revised in the recent Rome IV consensus. In gastroparesis, the symptom pattern and its similarities and differences from functional dyspepsia have been a focus of recent research. In functional dyspepsia, pathophysiological research continued to evaluate gastric sensorimotor dysfunctions, but low-grade inflammatory changes and loss of mucosal integrity in the duodenum is a new topic of intense research...
August 21, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28832080/a-retrospective-evaluation-of-the-epithelial-changes-lesions-and-neoplasms-of-the-gallbladder-in-turkey-and-a-review-of-the-existing-sampling-methods-a-multicentre-study
#15
Güldal Esendağlı, F Göknur Akarca, Serdar Balcı, Asuman Argon, Selma Şengiz Erhan, Nesrin Turhan, Neslihan İnce Zengin, Sevinç Hallaç Keser, Betül Çelik, Tangül Bulut, Samir Abdullazade, Esra Erden, Berna Savaş, Temmuz Bostan, Özgül Sağol, Anıl Aysal Ağalar, Nuray Kepil, Yıldırım Karslıoğlu, Armağan Günal, Fatma Markoç, Burcu Saka, Gonca Özgün, Şükrü Oğuz Özdamar, Burak Bahadır, Esin Kaymaz, Emre Işık, Semin Ayhan, Deniz Tunçel, Banu Özgüven Yılmaz, Sevinç Çelik, Tuba Karabacak, İpek Erbarut Seven, Çiğdem Ataizi Çelikel, Zuhal Gücin, Özgür Ekinci, Gülen Akyol
OBJECTIVE: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. MATERIAL AND METHOD: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28828195/critically-ill-patients-and-gut-motility-are-we-addressing-it
#16
REVIEW
Alfredo Vazquez-Sandoval, Shekhar Ghamande, Salim Surani
Gastrointestinal (GI) dysmotility is a common problem in the critically ill population. It can be a reflection and an early sign of patient deterioration or it can be an independent cause of morbidity and mortality. GI dysmotility can be divided for clinical purposes on upper GI dysmotility and lower GI dysmotility. Upper GI dysmotility manifests by nausea, feeding intolerance and vomiting; its implications include aspiration into the airway of abdominal contents and underfeeding. Several strategies to prevent and treat this condition can be tried and they include prokinetics and post-pyloric feeds...
August 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28819392/long-term-trends-in-primary-sites-of-gastric-adenocarcinoma-in-japan-and-the-united-states
#17
Michitaka Honda, Sandra L Wong, Mark A Healy, Toshifusa Nakajima, Masayuki Watanabe, Shingo Fukuma, Shunichi Fukuhara, John Z Ayanian
Background: The incidence and characteristics of gastric cancer have been shown to vary widely across Western and Eastern countries. Our study had two aims: to evaluate long-term trends in gastric adenocarcinoma in Japan over a period of 70 years, and to anticipate the future of gastric cancer in Japan, through comparison with data from the United States. Methods: Japanese patient data for 19,306 incident cases of gastric adenocarcinoma from 1946 - 2014 were collected from the Gastric Cancer Database at the Cancer Institute Hospital, Tokyo, Japan (CIH-GCDB)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28799027/optimal-lymphadenectomy-for-duodenal-adenocarcinoma-does-the-number-alone-matter
#18
Taro Sakamoto, Akio Saiura, Yoshihiro Ono, Yoshihiro Mise, Yosuke Inoue, Takeaki Ishizawa, Yu Takahashi, Hiromichi Ito
BACKGROUND: Duodenal adenocarcinoma (DA) is a rare disease, and the optimal extent of lymphadenectomy and the role of limited resection remain controversial. OBJECTIVE: The aim of our study was to assess the pattern of regional lymph node spread of DA and to determine the optimal extent of resection. METHODS: A total of 65 patients who underwent curative resection for DA at our institution from 1989 through 2015 were included in this study...
August 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28798951/histomorphological-description-of-the-digestive-system-of-pebbly-fish-alestes-baremoze-joannis-1835
#19
Nasser Kasozi, Gerald Iwe Degu, Julius Mukalazi, Charles Drago Kato, Majid Kisekka, Akisoferi Owori Wadunde, Godfrey Kityo, Victoria Tibenda Namulawa
Histomorphological studies of the digestive system of Alestes baremoze captured from Lake Albert, Uganda, were done using standard procedures. These revealed that A. baremoze has a fleshy-lipped terminal small mouth, large molar, short oesophagus, a three-lobed liver, pouch-like stomach, a nine-fingered caeca, and a long tubular intestine. A stratified squamous epithelium with numerous mucus-secreting cells lined the lips with no taste buds. Stratified squamous epithelia lined the oesophagus in the anterior portion which turned into a columnar epithelium towards the stomach...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28770145/a-difficult-recurrent-hypertrophic-pyloric-stenosis
#20
Hamdi Louati, Hayet Zitouni, Manel Belhajmansour, Mahdi Ben Dhaou, Mohamed Jalouli, Riadh Mhiri, Rim Kallel, Tahya Boudawara
No abstract text is available yet for this article.
April 2017: Journal of Neonatal Surgery
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