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Clinical Usefulness

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https://www.readbyqxmd.com/read/29356450/a-prospective-study-of-fetal-head-growth-autistic-traits-and-autism-spectrum-disorder
#1
Laura M E Blanken, Alena Dass, Gail Alvares, Jan van der Ende, Nikita K Schoemaker, Hanan El Marroun, Martha Hickey, Craig Pennell, Scott White, Murray T Maybery, Cheryl Dissanayake, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier, Will McIntosh, Tonya White, Andrew Whitehouse
Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population-based cohorts, including a sample of individuals with clinically diagnosed ASD...
January 22, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29356441/parent-and-clinician-agreement-regarding-early-behavioral-signs-in-12-and-18-month-old-infants-at-risk-of-autism-spectrum-disorder
#2
Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Susan Bryson, Jessica Brian, Isabel M Smith, Wendy Roberts, Peter Szatmari, Tracy Vaillancourt, Caroline Roncadin, Nancy Garon
Parent and clinician agreement regarding early behavioral signs of Autism Spectrum Disorder (ASD) in children from a high-risk cohort (siblings of children diagnosed with ASD, n = 188) was examined. Infants were assessed prospectively at 12 and 18 months of age using the clinician administered Autism Observational Scale for Infants (AOSI) and the Autism Parent Screen for Infants (APSI) and underwent a blind independent diagnostic assessment for ASD at 36 months of age. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent-reported symptoms being better able to differentiate between children with and without ASD at both 12 and 18 months of age compared to clinician observations during a brief office visit...
January 22, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29356438/impact-of-tobacco-alcohol-and-cannabis-use-on-treatment-outcomes-among-patients-experiencing-first-episode-psychosis-data-from-the-national-raise-etp-study
#3
Oladunni Oluwoye, Maria Monroe-DeVita, Ekaterina Burduli, Lydia Chwastiak, Sterling McPherson, Jon M McClellan, Michael G McDonell
AIM: The primary aim of this study was to examine the effect of recent tobacco, alcohol and cannabis use on treatment outcomes among participants experiencing first episode psychosis (FEP). METHODS: Secondary data analyses were conducted on 404 participants enrolled in the Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study. RAISE-ETP investigated the effectiveness of a coordinated specialty care (CSC) intervention for FEP in community mental health agencies in the United States...
January 22, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29356436/health-insurance-and-use-of-recommended-routine-care-in-adults-with-cystic-fibrosis
#4
Susan S Li, Don Hayes, Joseph D Tobias, Wayne J Morgan, Dmitry Tumin
BACKGROUND: Low socioeconomic status is correlated with worse outcomes in patients with cystic fibrosis. Whether insurance status impacts adherence to care in this population is unknown. METHODS: Patients ≥18 years old in the CF Foundation Patient Registry (2005-2013) were grouped based on reported annual insurance as private, public (Medicaid, Medicare, or state medical assistance program), other, or no insurance. Random effects logistic regression evaluated association between change in insurance status and annual use of recommended routine care...
January 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29356410/neonatal-swallowing-assessment-using-fiberoptic-endoscopic-evaluation-of-swallowing-fees
#5
Susanne Vetter-Laracy, Borja Osona, Antonia Roca, Jose A Peña-Zarza, Jose A Gil, Joan Figuerola
OBJECTIVES: Swallowing disorders which lead to aspiration are common in premature infants with a postmenstrual age (PMA) of >36 weeks. Aspiration is often silent and the unique symptom is desaturation during feeding. The aim of this study was 1) to determine the number of prematures with desaturations during feeding due to aspiration, using Fiberoptic Endoscopic Evaluation of Swallowing (FEES); 2) to relate clinical factors and FEES findings to aspiration; and 3) to describe type and efficacy of suggested treatments...
January 22, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29356376/boosting-art-uptake-and-retention-among-hiv-infected-pregnant-and-breastfeeding-women-and-their-infants-the-promise-of-innovative-service-delivery-models
#6
Meena Srivastava, David Sullivan, B Ryan Phelps, Surbhi Modi, Laura N Broyles
INTRODUCTION: With the rapid scale-up of antiretroviral treatment (ART) in the "Treat All" era, there has been increasing emphasis on using differentiated models of HIV service delivery. The gaps within the clinical cascade for mothers and their infants suggest that current service delivery models are not meeting families' needs and prompt re-consideration of how services are provided. This article will explore considerations for differentiated care and encourage the ongoing increase of ART coverage through innovative strategies while also addressing the unique needs of mothers and infants...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29356353/effect-of-the-prevent-alcohol-and-risk-related-trauma-in-youth-p-a-r-t-y-program-among-senior-school-students
#7
Anna Gunn, Janet McLeod, Rebecca Chapman, Hayley Ball, Mark Fitzgerald, Teresa Howard, Peter Cameron, Biswadev Mitra
OBJECTIVE: The Prevent Alcohol and Risk-Related Trauma in Youth (P.A.R.T.Y.) Program at The Alfred uses vivid clinical reality to build resilience and prevent injury by following a trauma patient's journey through hospital. The present study aims to analyse the effect of P.A.R.T.Y. on safety perceptions of driving after alcohol, seat belt use and risk-taking activities. METHODS: Pre-programme, immediately post-programme and 3-5 months post-programme surveys with questions focused on the programme aims were distributed to all consented participants...
January 21, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29356351/how-adolescents-decide-on-bariatric-surgery-an-interpretative-phenomenological-analysis
#8
J Doyle, S Colville, P Brown, D Christie
The National Institute of Clinical Excellence states that bariatric surgery may be considered for adolescents with severe obesity in 'exceptional circumstances'. However, it is not clear what is deemed to be exceptional, and there is a lack of long-term outcomes data or research, which would inform patient selection. This is an in-depth qualitative study involving five adolescents who had previously undergone bariatric surgery (between 1 and 3 years postoperatively) and four who were being assessed for the treatment...
January 21, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29356346/predicting-the-hearing-outcome-in-sudden-sensorineural-hearing-loss-via-machine-learning-models
#9
Dan Bing, Jun Ying, Jun Miao, Lan Lan, Dayong Wang, Lidong Zhao, Zifang Yin, Lan Yu, Jing Guan, Qiuju Wang
OBJECTIVE: Sudden sensorineural hearing loss (SSHL) is a multifactorial disorder with high heterogeneity, thus the outcomes vary widely. The present study aimed to develop predictive models based on four machine learning methods for SSHL, identifying the best performer for clinical application. DESIGN: Single-center retrospective study. SETTING: Chinese People's liberation army (PLA) hospital, Beijing, China. PARTICIPANTS: 1220 in-patient SSHL patients were enrolled between June 2008 and December 2015...
January 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29356341/cryopreserved-neonatal-hepatocytes-may-be-a-source-for-transplantation-evaluation-of-functionality-towards-clinical-use
#10
Charlotte A Lee, Anil Dhawan, Valeria Iansante, Sharon Lehec, Shirin Elizabeth Khorsandi, Celine Filippi, Simon Walker, Raquel Fernandez-Dacosta, Nigel Heaton, Sanjay Bansal, Ragai R Mitry, Emer Fitzpatrick
Neonatal livers are a potential source of good quality hepatocytes for clinical transplantation. We compared viability and function of neonatal and adult hepatocytes, and report their clinical use both intra-portally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1 antitrypsin and factor VII. Metabolic function was investigated by measuring resorufin conjugation, ammonia metabolism, UGT enzyme activity and cytochrome P450 function following induction...
January 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29356314/plasma-metabolome-analysis-of-patients-with-major-depressive-disorder
#11
Noriyuki Kawamura, Kosaku Shinoda, Hajime Sato, Kazunori Sasaki, Makoto Suzuki, Kumi Yamaki, Tamaki Fujimori, Hiroyuki Yamamoto, Douglas Osei-Hyiaman, Yoshiaki Ohashi
AIM: This study sought to characterize the plasma metabolite profiling of patients with major depressive disorder (MDD). METHODS: Psychiatric assessments were made with the Structured Clinical Interview for Diagnosis. In the exploratory cohort, plasma metabolite profiles of 34 MDD patients and 31 mentally healthy controls were compared using capillary electrophoresis-mass spectrometry. Among the candidate metabolites, we focused on a metabolite showing the largest difference...
January 22, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29356281/episode-forecasting-in-bipolar-disorder-is-energy-better-than-mood
#12
Abigail Ortiz, Kamil Bradler, Arend Hintze
OBJECTIVE: Bipolar disorder is a severe mood disorder characterized by alternating episodes of mania and depression. Several interventions have been developed to decrease high admission rates and high suicides rates associated with the illness, including psychoeducation and early episode detection, with mixed results. More recently, machine learning approaches have been used to aid clinical diagnosis or to detect a particular clinical state; however, contradictory results arise from confusion around which of the several automatically generated data are the most contributory and useful to detect a particular clinical state...
January 22, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29356278/antiplatelet-drug-selection-in-pci-to-vein-grafts-in-patients-with-acute-coronary-syndrome-and-adverse-clinical-outcomes-insights-from-the-british-cardiovascular-intervention-society-database
#13
Alex Sirker, Chun Shing Kwok, Evangelos Kontopantelis, Tom Johnson, Philip Freeman, Mark A de Belder, Peter Ludman, Azfar Zaman, Mamas A Mamas
OBJECTIVE: This study aims to evaluate outcomes associated with different P2Y12 agents in Saphenous Vein graft (SVG) percutaneous coronary intervention (PCI). BACKGROUND: SVG PCI is associated with greater risks of ischemic complications, compared with native coronary PCI. Outcomes associated with the use of potent P2Y12 blocking drugs, Prasugrel and Ticagrelor, in SVG PCI are unknown. METHODS: Patients included in the study underwent SVG PCI in the United Kingdom between 2007 and 2014 for acute coronary syndrome and were grouped by P2Y12 antiplatelet use...
January 22, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29356273/unknown-onset-strokes-with-anterior-circulation-occlusion-treated-by-thrombectomy-after-dwi-flair-mismatch-selection
#14
Simon Escalard, Benjamin Gory, Maéva Kyheng, Jean-Philippe Desilles, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Julien Labreuche, Mikael Mazighi, Michel Piotin, Raphaël Blanc, Bertrand Lapergue, Robert Fahed
BACKGROUND AND PURPOSE: The DAWN Trial recently showed compelling evidence in treating late window and wake-up stroke patients with thrombectomy using a clinical-imaging mismatch. We aimed to evaluate the results of thrombectomy for unknown-onset strokes (UOS) treated in our centers after a DWI-FLAIR mismatch based selection. METHODS: We performed a multicenter, cohort study of consecutive UOS treated by thrombectomy between 2012 and 2016. We compared UOS with proximal anterior circulation occlusion discovered beyond 6 hours from "last seen normal" with known-onset strokes (KOS) for whom thrombectomy was started within 6 hours from onset...
January 21, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29356271/assessment-of-the-efficacy-and-tolerance-of-an-innovative-regenerative-serum-on-cutaneous-regeneration-following-fractional-laser-procedure-using-erbium-yag
#15
Natalia Jiménez, Angela Hermosa, Laura de Miguel, Natalia Sánchez-Neila, Maria Teresa Truchuelo, Itziar Eraña, Jesus Cuevas
INTRODUCTION: Cutaneous regeneration, fractional laser, medical device, cellular proliferation cutaneous changes linked to photoaging are currently treated with physical treatments, such as fractional laser, which may induce epidermal alteration. OBJECTIVE: To determine the efficacy and safety of a regenerative serum (Matricium® , Laboratoire Bioderma, France) after laser procedure. METHODS: Prospective, double-blind, controlled, and randomized study in subjects with photoaged skin...
January 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29356230/maternal-and-child-health-nurses-work-with-refugee-families-perspectives-from-regional-victoria-australia
#16
Suzanne M Willey, Robyn P Cant, Allison Williams, Meredith McIntyre
AIMS AND OBJECTIVES: This study aimed to explore service provision for Victorian regional refugee families from the perspective of Maternal and Child Health nurses. BACKGROUND: Increasingly, more families from a refugee background are resettling in regional Victoria. The refugee journey has significant effect on families. Refugee families with infants and young children can be provided with support by Maternal and Child Health services; however, many families experience barriers to ongoing engagement with this service...
January 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29356212/emerging-strategies-of-cancer-therapy-based-on-ferroptosis
#17
REVIEW
Zheyu Shen, Jibin Song, Bryant C Yung, Zijian Zhou, Aiguo Wu, Xiaoyuan Chen
Ferroptosis, a new form of regulated cell death that is iron- and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy...
January 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29356210/clinical-course-and-prognostic-factors-across-different-musculoskeletal-pain-sites-a-secondary-analysis-of-individual-patient-data-from-randomised-clinical-trials
#18
D J Green, M Lewis, G Mansell, M Artus, K S Dziedzic, E M Hay, N E Foster, D A van der Windt
BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentation. METHODS: Data from seven RCTs (2,483 participants) evaluating a range of primary care interventions for different MSK pain conditions were used to investigate the course of symptoms and explore similarities and differences in predictors of outcome...
January 22, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29356208/improving-recruitment-to-pharmacological-trials-for-illicit-opioid-use-findings-from-a-qualitative-focus-group-study
#19
Joanne Neale, Charlotte N E Tompkins, Rebecca McDonald, John Strang
AIM: To explore potential study participants' views on willingness to join clinical trials of pharmacological interventions for illicit opioid use to inform and improve future recruitment strategies. DESIGN: Qualitative focus group study (6 groups: oral methadone [2 groups]; buprenorphine tablets [2 groups]; injectable opioid agonist treatment [1 group]; and former opioid agonist treatment [1 group]). SETTINGS: Drug and alcohol services and a peer support recovery service (London, United Kingdom)...
January 22, 2018: Addiction
https://www.readbyqxmd.com/read/29356205/antiviral-potential-of-medicinal-plants-against-hiv-hsv-influenza-hepatitis-and-coxsackievirus-a-systematic-review
#20
REVIEW
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
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