keyword
MENU ▼
Read by QxMD icon Read
search

In the treatment of

keyword
https://www.readbyqxmd.com/read/29913543/recommendations-for-the-use-of-testosterone-in-male-transgender
#1
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913540/-significance-of-matrix-augmented-bone-marrow-stimulation-for-treatment-of-cartilage-defects-of-the-knee-a-consensus-statement-of-the-dgou-working-group-on-tissue-regeneration
#2
Philipp Niemeyer, Christoph Becher, Matthias Buhs, Stefan Fickert, Kolja Gelse, Daniel Günther, Raphael Kaelin, Peter Kreuz, Jörg Lützner, Stefan Nehrer, Henning Madry, Stefan Marlovits, Julian Mehl, Henning Ott, Matthias Pietschmann, Gunther Spahn, Thomas Tischer, Martin Volz, Markus Walther, Götz Welsch, Johannes Zellner, Wolfgang Zinser, Peter Angele
Surgical principles for treatment of full-thickness cartilage defects of the knee include bone marrow stimulation techniques (i.e. arthroscopic microfracturing) and transplantation techniques (i.e. autologous chondrocyte implantation and osteochondral transplantation). On the basis of increasing scientific evidence, indications for these established therapeutical concepts have been specified and clear recommendations for practical use have been given. Within recent years, matrix-augmented bone marrow stimulation has been established as a new treatment concept for chondral lesions...
June 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29913536/hemostasis-in-the-very-young
#3
Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913532/ligation-assisted-endoscopic-submucosal-resection-with-apical-mucosal-incision-to-treat-gastric-subepithelial-tumors-originating-from-the-muscularis-propria
#4
Dingguo Zhang, Qiuling Lin, Ruiyue Shi, Lisheng Wang, Jun Yao, Yanhui Tian
BACKGROUND:  This study aimed to evaluate the clinical efficacy, safety, and feasibility of performing endoscopic submucosal resection with a ligation device (ESMR-L) after apical mucosal incision (AMI) for the treatment of gastric subepithelial tumors originating from the muscularis propria (SET-MPs). METHODS:  14 patients with gastric SET-MPs were treated by ESMR-L with AMI between December 2016 and May 2017. The complete resection rate, operation duration, and postoperative complications were collected...
June 18, 2018: Endoscopy
https://www.readbyqxmd.com/read/29913528/blood-pressure-and-cognitive-performance-after-a-single-administration-of-a-camphor-crataegus-combination-in-adolescents-with-low-blood-pressure
#5
Rainer Schandry, Daniela Lindauer, Matthias Mauz
Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 - 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking...
June 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913523/dental-imaging-a-basic-guide-for-the-radiologist
#6
Max Masthoff, Mirjam Gerwing, Malte Masthoff, Maximilian Timme, Johannes Kleinheinz, Markus Berninger, Walter Heindel, Moritz Wildgruber, Christoph Schülke
BACKGROUND:  As dental imaging accounts for approximately 40 % of all X-ray examinations in Germany, profound knowledge of this topic is essential not only for the dentist but also for the clinical radiologist. This review focuses on basic imaging findings regarding the teeth. Therefore, tooth structure, currently available imaging techniques and common findings in conserving dentistry including endodontology, periodontology, implantology and dental trauma are presented. METHODS:  Literature research on the current state of dental radiology was performed using Pubmed...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913522/contrast-media-extravasation-in-ct-and-mri-a-literature-review-and-strategies-for-therapy
#7
Veronika Mandlik, Lukas Prantl, Andreas G Schreyer
BACKGROUND:  Contrast extravasation events in daily radiological routine may lead to serious complications, especially during CT examinations. The resulting symptoms may vary from local pain up to skin ulcers, necrosis or even acute compartment syndrome.There are no uniformly accepted radiological guidelines or recommendations regarding detection and treatment of extravasation events and immanent complications in a timely manner. METHOD:  Systematic literature research considering the last 35 years via PubMed using search terms "contrast medium extravasation/paravasation"...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913521/comparison-of-efficacy-embolism-rate-and-safety-of-thrombectomy-with-stent-retrievers-in-an-anterior-circulation-stroke-model
#8
Naomi Larsen, Katharina Oberbeck, Rodrigo Lima de Miranda, Jens Trentmann, Jawid Madjidyar, Eckhard Quandt, Olav Jansen
PURPOSE:  Various stent retrievers differing in stent design and mechanical properties are currently available for the treatment of ischemic stroke. We conducted this in vitro study to compare the efficacy, embolism rate, and safety of commercially available stent retrievers and prototypes. MATERIALS AND METHODS:  Whole blood thrombi were produced in a Chandler loop. The thrombi were inserted into the curved M1 segment of a silicone model of the anterior cerebral circulation...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913517/periradicular-infiltration-of-the-cervical-spine-how-new-ct-scanner-techniques-and-protocol-modifications-contribute-to-the-achievement-of-low-dose-interventions
#9
Fabian Henry Jürgen Elsholtz, Julia Evi-Katrin Kamp, Janis Lucas Vahldiek, Bernd Hamm, Stefan Markus Niehues
PURPOSE:  CT-guided periradicular infiltration of the cervical spine is an effective symptomatic treatment in patients with radiculopathy-associated pain syndromes. This study evaluates the robustness and safety of a low-dose protocol on a CT scanner with iterative reconstruction software. MATERIALS AND METHODS:  A total of 183 patients who underwent periradicular infiltration therapy of the cervical spine were included in this study. 82 interventions were performed on a new CT scanner with a new intervention protocol using an iterative reconstruction algorithm...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913516/medication-for-opioid-use-disorder-after-nonfatal-opioid-overdose-and-association-with-mortality-a-cohort-study
#10
Marc R Larochelle, Dana Bernson, Thomas Land, Thomas J Stopka, Na Wang, Ziming Xuan, Sarah M Bagley, Jane M Liebschutz, Alexander Y Walley
Background: Opioid overdose survivors have an increased risk for death. Whether use of medications for opioid use disorder (MOUD) after overdose is associated with mortality is not known. Objective: To identify MOUD use after opioid overdose and its association with all-cause and opioid-related mortality. Design: Retrospective cohort study. Setting: 7 individually linked data sets from Massachusetts government agencies...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913483/the-associations-between-the-growth-hormone-insulin-like-growth-factor-1-axis-adiponectin-resistin-and-metabolic-profile-in-children-with-growth-hormone-deficiency-before-and-during-growth-hormone-treatment
#11
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Anna Majcher, Beata Pyrżak
This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913480/dendrimer-paclitaxel-complexes-for-efficient-treatment-in-ovarian-cancer-study-on-ovcar-3-and-hek293t-cells
#12
Hua Yao, Jinqi Ma
The present paper investigates the enhancement of the therapeutic effect of Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in the cancerous cells with subsequent reduction in its cytotoxic effects. To fulfill these goals the Paclitaxel (PTX)-Biotinylated PAMAM dendrimer complexes were prepared using biotinylation method. The primary parameter of Biotinylated PAMAM with a terminal HN2 group - the degree of biotinylation - was evaluated using HABA assay. The basic integrity of the complex was studied using DSC...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913457/anti-inflammatory-action-of-sitagliptin-and-linagliptin-in-doxorubicin-nephropathy
#13
Chor Ho Jo, Sua Kim, Joon-Sung Park, Gheun-Ho Kim
BACKGROUND/AIMS: Dipeptidyl peptidase-4 (DPP4) inhibitors are known to have a protective effect on diabetic kidney disease, possibly via reduction of oxidative stress and inflammation in the kidney. However, whether these potential mechanisms play a role in non-diabetic proteinuric kidney diseases is not clear. METHODS: Two different animal experiments were carried out using sitagliptin and linagliptin for DPP4 inhibition. In each experiment, male Sprague-Dawley rats were uninephrectomized and randomly divided into vehicle-treated and doxorubicin-treated rats, with or without DPP4 inhibition...
June 15, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29913454/ra190-a-proteasome-subunit-adrm1-inhibitor-suppresses-intrahepatic-cholangiocarcinoma-by-inducing-nf-kb-mediated-cell-apoptosis
#14
Guang-Yang Yu, Xuan Wang, Su-Su Zheng, Xiao-Mei Gao, Qing-An Jia, Wen-Wei Zhu, Lu Lu, Hu-Liang Jia, Jin-Hong Chen, Qiong-Zhu Dong, Ming Lu, Lun-Xiu Qin
BACKGROUND/AIMS: Effective drug treatment for intrahepatic cholangiocarcinoma (ICC) is currently lacking. Therefore, there is an urgent need for new targets and new drugs that can prolong patient survival. Recently targeting the ubiquitin proteasome pathway has become an attractive anti-cancer strategy. In this study, we aimed to evaluate the therapeutic effect of and identify the potential mechanisms involved in targeting the proteasome subunit ADRM1 for ICC. METHODS: The expression of ADRM1 and its prognostic value in ICC was analyzed using GEO and TCGA datasets, tumor tissues, and tumor tissue arrays...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913449/pre-treatment-with-melatonin-enhances-therapeutic-efficacy-of-cardiac-progenitor-cells-for-myocardial-infarction
#15
Wenya Ma, Fang He, Fengzhi Ding, Lai Zhang, Qi Huang, Chongwei Bi, Xiuxiu Wang, Bingjie Hua, Fan Yang, Ye Yuan, Zhenbo Han, Mengyu Jin, Tianyi Liu, Ying Yu, Benzhi Cai, Yanjie Lu, Zhimin Du
BACKGROUND/AIMS: Melatonin possesses many biological activities such as antioxidant and anti-aging. Cardiac progenitor cells (CPCs) have emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the low survival of transplanted CPCs in infarcted myocardium limits the successful use in treating MI. In the present study, we aimed to investigate if melatonin protects against oxidative stress-induced CPCs damage and enhances its therapeutic efficacy for MI. METHODS: TUNEL assay and EdU assay were used to detect the effects of melatonin and miR-98 on H2O2-induced apoptosis and proliferation...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913444/stimulation-of-eryptosis-by-afatinib
#16
Abdulla Al Mamun Bhuyan, Florian Lang
BACKGROUND/AIMS: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor afatinib is primarily utilized for the treatment of non-small cell lung carcinoma. The drug is at least partially effective by triggering suicidal tumor cell death. Side effects of afatinib treatment include anemia. At least in theory, afatinib induced anemia could be secondary to stimulation of suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913439/lncrna-lcpat1-mediates-smoking-particulate-matter-2-5-induced-cell-autophagy-and-epithelial-mesenchymal-transition-in-lung-cancer-cells-via-rcc2
#17
Hongyan Lin, Xiaohong Zhang, Nannan Feng, Ruoyang Wang, Weituo Zhang, Xiaobei Deng, Yu Wang, Xiao Yu, Xiaofei Ye, Lei Li, Ying Qian, Herbert Yu, Biyun Qian
BACKGROUND/AIMS: Ecological studies have shown that air pollution and prevalence of cigarette smoking are positively correlated. Evidence also suggests a synergistic effect of cigarette smoking and PM2.5 exposure (Environmental Particulate Matter ≤ 2.5 µm in diameter) on lung cancer risk. We aimed to evaluate the interaction between smoking prevalence and PM2.5 pollution in relation to lung cancer mortality and determine its underlying mechanisms in vitro. METHODS: "MOVER" method was used to analyze the interaction between smoking prevalence and PM2...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913438/race-age-and-gender-based-characteristics-and-toxicities-of-targeted-therapies-on-phase-i-trials
#18
Taofeek K Owonikoko, Adeniyi K Busari, Sungjin Kim, Zhengjia Chen, Adebowale Akintayo, Colleen Lewis, Bradley C Carthon, Olatunji B Alese, Bassel F El-Rayes, Suresh S Ramalingam, R Donald Harvey
BACKGROUND: The impact of age-, gender-, and race-based differences on safety and efficacy in phase I clinical trials has not been well studied. METHODS: We analyzed data from phase I clinical trials evaluating targeted biologic agents in patients with advanced solid malignancies. Race and gender distribution of enrolled patients was compared to the referral population demographics at the city, metro, and state levels. The association between age, gender, and race with type, frequency, and severity of treatment-emergent toxicities and clinical benefit was assessed using univariate and multivariable models...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913437/thymoquinone-attenuates-myocardial-ischemia-reperfusion-injury-through-activation-of-sirt1-signaling
#19
Yunyang Lu, Yingda Feng, Dan Liu, Zhiran Zhang, Kai Gao, Wei Zhang, Haifeng Tang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913426/heat-treatment-improves-the-immunomodulatory-and-cellular-antioxidant-behavior-of-a-natural-flavanone-eriodictyol
#20
Rihab Khlifi, Zaineb Dhaouefi, Mouna Maatouk, Aicha Sassi, Najet Boudhiba, Irina Ioannou, Kamel Ghedira, Leila Chekir-Ghedira, Soumaya Kilani-Jaziri
Plants and natural molecules are generally consumed not in raw state but after different processing conditions (heating, mechanical agitation or cooking). The understanding of the chemistry and biological outcome of thermal treatment is still scarce. In the current study, Eriodictyol, a natural flavanone, has undergone heat treatment, generating hence three different products ((3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, (3-(3,4-dihydroxyphenyl) propanal) and an unidentified component). The consequences of aforementioned treatment on the immunomodulatory behavior of resulted molecules were evaluated...
June 15, 2018: International Immunopharmacology
keyword
keyword
61868
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"