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https://www.readbyqxmd.com/read/28239889/the-dark-corner-of-the-heart-understanding-and-embracing-suffering-as-portrayed-by-adults
#1
Jessica Hemberg
BACKGROUND: Suffering profoundly touches the human being's inner existence. The different faces of suffering may yet be unknown, and therefore, it is important to further explore suffering in order to reach a new and deeper understanding of it and its alleviation. THE AIM AND RESEARCH QUESTIONS: The aim of this study was to expand the understanding of suffering. The research questions are what is suffering as described by the human beings themselves and what initiates a movement in suffering towards its alleviation? RESEARCH DESIGN, PARTICIPANTS AND RESEARCH CONTEXT: The study uses a hermeneutical approach and hermeneutical reading...
February 26, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28239547/unmasking-of-myoclonus-by-lacosamide-in-generalized-epilepsy
#2
Daniel Birnbaum, Mohamad Koubeissi
Lacosamide is a new-generation antiseizure medication that is approved for use as an adjunctive treatment and monotherapy in focal epilepsy. Its use in generalized epilepsy, however, has not been adequately evaluated in controlled trials. We report a 67-year-old woman who experienced new-onset myoclonic seizures after initiation of lacosamide. We presume that she had an undiagnosed generalized epilepsy syndrome, likely juvenile myoclonic epilepsy. Myoclonic seizures were not reported before introducing lacosamide and completely resolved after lacosamide was discontinued...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28239444/locomotory-control-in-amphioxus-larvae-new-insights-from-neurotransmitter-data
#3
EDITORIAL
Thurston Lacalli, Simona Candiani
Amphioxus larvae have a midbrain-level locomotory control center whose overall organization is known from serial TEM reconstructions. How it functions has been a puzzle, owing to uncertainty as to the transmitters used by each class of neurons, but this has recently become clearer. We summarize what is now known, and correct past misconceptions: The large paired neurons at the core of the control center are glutamatergic, and hence excitatory, the commissural neurons are GABAergic, hence probably inhibitory, and both motoneurons and ipsilateral projection neurons are cholinergic, suggesting that the latter, a class of interneurons, may be derived evolutionarily from the former...
2017: EvoDevo
https://www.readbyqxmd.com/read/28238056/what-s-new-with-stress-ulcer-prophylaxis-in-the-icu
#4
Søren Marker, Mette Krag, Morten Hylander Møller
No abstract text is available yet for this article.
February 25, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28236988/-what-can-we-expect-from-clinical-trials-in-psychiatry
#5
A Marsot, Q Boucherie, F Kheloufi, C Riff, D Braunstein, J Dupouey, R Guilhaumou, X Zendjidjian, S Bonin-Guillaume, E Fakra, M Guye, V Jirsa, J-M Azorin, R Belzeaux, M Adida, J Micallef, O Blin
Clinical trials in psychiatry allow to build the regulatory dossiers for market authorization but also to document the mechanism of action of new drugs, to build pharmacodynamics models, evaluate the treatment effects, propose prognosis, efficacy or tolerability biomarkers and altogether to assess the impact of drugs for patient, caregiver and society. However, clinical trials have shown some limitations. Number of recent dossiers failed to convince the regulators. The clinical and biological heterogeneity of psychiatric disorders, the pharmacokinetic and pharmacodynamics properties of the compounds, the lack of translatable biomarkers possibly explain these difficulties...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236987/-what-place-for-placebo-in-clinical-trials-conducted-on-psychiatric-patients
#6
M Cermolacce, R Belzeaux, M Adida, J-A Micoulaud Franchi, E Fakra, J-M Azorin
Placebo effect remains a crucial issue in current clinical trials. Most clinical trials rely on the hypothesis of equivalent placebo response rates in both placebo and specific drug arms ("additive model"). But contrary to this dominant and rarely questioned hypothesis, several aspects may influence placebo response. A few recent meta-analyses and reviews have shown evidence for several clinical and methodological factors, which are able to modulate placebo response. In psychiatry research, placebo response has been mainly explored through antidepressant trials...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236986/-inclusion-criteria-and-rating-scales-for-rcts-in-psychiatry-the-future-of-qualitative-studies
#7
D Pringuey, R Pommier, F Pringuey-Criou, S Boyer, C Massoubre, E Fakra, M Adida, R Belzeaux, T Bottai, J-M Azorin
An inventory on the two critical dimensions that structure the Randomized Controlled Trial in Psychiatry, namely the definition of inclusion criteria for eligible patients for testing and the choice of psychometric methods of pathology assessment and its evolution during the experiment, considers the importance of increasingly numerous and precise international recommendations. Taking into account the formal constraints of industrial, questioning the cultural differences of the methodological approach of the tests, meeting the requirements of feasibility and ever increasing security, frequent cumbersome procedure often contrasts with the modest nature of the results...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236904/-what-s-new-in-thoracic-imaging
#8
EDITORIAL
M-L Chabi
No abstract text is available yet for this article.
February 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28236452/multiparametric-magnetic-resonance-imaging-and-prostate-cancer-what-s-new
#9
V Catalá, J C Vilanova, J M Gaya, F Algaba, T Martí
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to present an updated revision of technical aspects, reading patterns and prostatic MP-MRI in Pca, with a multidisciplinary approach. Currently guidelines establish the use of the MP-MRI when there is a high PSA and a negative prostatic biopsy; tumor staging; evaluation in candidates to active surveillance; focal treatments plans and tumoral recurrence evaluation...
February 21, 2017: Radiología
https://www.readbyqxmd.com/read/28236132/double-read-of-skeletal-surveys-in-suspected-non-accidental-trauma-what-we-learned
#10
Boaz Karmazyn, Elise M Miller, Sara E Lay, James M Massey, Matthew R Wanner, Megan B Marine, S Gregory Jennings, Fangqian Ouyang, Roberta A Hibbard
BACKGROUND: Missing a fracture in a child on skeletal surveys for suspected non-accidental trauma can have devastating results. Double-read has the potential to improve fracture detection. However the yield of double-read is unknown. OBJECTIVE: To determine the advantage of double-read versus single-read of radiographic skeletal surveys for suspected non-accidental trauma. MATERIALS AND METHODS: The study was performed in two phases. In the first phase (April 2013 to September 2013), double-read was performed for all skeletal surveys obtained during weekday working hours...
February 24, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28236079/the-2017-abjs-nicolas-andry-award-advancing-personalized-medicine-for-clubfoot-through-translational-research
#11
Matthew B Dobbs, Christina A Gurnett
BACKGROUND: Clubfoot is one of the most common pediatric orthopaedic disorders. While the Ponseti method has revolutionized clubfoot treatment, it is not effective for all patients. When the Ponseti method does not correct the foot, patients are at risk for lifelong disability and may require more-extensive surgery. QUESTIONS/PURPOSES: (1) What genetic and morphologic abnormalities contribute to the development of clubfoot? (2) How can this information be used to devise personalized treatment paradigms for patients with clubfoot? METHODS: Human gene sequencing, molecular genetic engineering of mouse models of clubfoot, MRI of clubfoot, and development of new treatment methods all have been used by our group to understand the biological basis and improve therapy for this group of disorders...
February 24, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28236027/validation-of-the-custo-screen-pediatric-blood-pressure-monitor-according-to-the-european-society-of-hypertension-international-protocol-revision-2010
#12
Beate Beime, Cornelia Deutsch, Ralf Krüger, Andreas Wolf, Peter Müller, Gertrud Hammel, Peter Bramlage
: The purpose of the study was to validate the ambulatory blood pressure monitoring (ABPM) device custo screen pediatric in children aged 3 to 12 years according to the International Protocol of the European Society of Hypertension (ESH-IP revision 2010). Thirty-three children were included and systolic and diastolic blood pressure measurements were performed according to the ESH-IP. The protocol was modified for children considering data from the German Health Interview and Examination Survey for Children and Adolescents (KIGGS)...
February 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28235893/single-neurons-in-the-avian-auditory-cortex-encode-individual-identity-and-propagation-distance-in-naturally-degraded-communication-calls
#13
Solveig C Mouterde, Julie E Elie, Nicolas Mathevon, Frédéric E Theunissen
One of the most complex tasks performed by sensory systems is "scene analysis": the interpretation of complex signals as behaviorally relevant objects. The study of this problem, universal to species and sensory modalities, is particularly challenging in audition, where sounds from various sources and localizations, degraded by propagation through the environment, sum to form a single acoustical signal. Here we investigated in a songbird model, the zebra finch, the neural substrate for ranging and identifying a single source...
February 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28235696/what-psychological-process-is-reflected-in-the-fn400-event-related-potential-component
#14
P Andrew Leynes, Heather Bruett, Jenna Krizan, Ana Veloso
During many recognition contexts, old items elicit a more positive event-related potentials (ERPs) than new items at mid-frontal electrodes about 300-500ms. The psychological processes that are reflected in is ERP component (i.e., the FN400) has been vigorously debated. Some argue that the FN400 reflects familiarity, whereas others argue that it reflects conceptual implicit memory. Three experiments contrasted these two hypotheses by presenting pre-experimentally familiar (i.e., name-brand) products and novel, off-brand products...
February 21, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28235507/hypnopraxia-a-new-hypnotic-technique-for-hypnoanesthesia
#15
Nicolas Drouet, Guy Chedeau
Various hypnotic techniques are used in anesthesia, either on their own or as adjuncts. A new hypnotic technique, hypnopraxia, was tested in 5 patients undergoing various procedures (4 colonoscopies, 1 inguinal hernia repair, and 1 transobturator tape procedure). The patients were accompanied throughout the procedure by an anesthetist trained in hypnoanesthesia and hypnopraxia. Initially developed for use in hypnotherapy, the accompaniment with hypnopraxia relied on the closeness of the link between the anesthetist and the patient...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28231539/a-new-model-to-predict-diffusive-self-heating-during-composting-incorporating-the-reaction-engineering-approach-rea-framework
#16
Aditya Putranto, Xiao Dong Chen
During composting, self-heating may occur due to the exothermicities of the chemical and biological reactions. An accurate model for predicting maximum temperature is useful in predicting whether the phenomena would occur and to what extent it would have undergone. Elevated temperatures would lead to undesirable situations such as the release of large amount of toxic gases or sometimes would even lead to spontaneous combustion. In this paper, we report a new model for predicting the profiles of temperature, concentration of oxygen, moisture content and concentration of water vapor during composting...
February 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28230629/point-of-injury-tourniquet-application-during-operation-protective-edge-what-de-we-learn
#17
Amir Shlaifer, Avraham Yitzhak, Erez N Baruch, Avi Shina, Alexandra Satanovsky, Amiram Shovali, Ofer Almog, Elon Glassberg
BACKGROUND: Hemorrhage is a leading cause of preventable death on the battlefield. Timely tourniquet application to massively bleeding extremity wounds is critical for casualty survival albeit with reported adverse effects to extremity integrity. The aim of this study was to describe the immediate and short term outcomes of point of injury (POI) tourniquet applications during 'Operation Protective Edge' (OPE). METHODS: A case series study regarding tourniquet application at the POI during OPE was collected...
February 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28229960/what-history-tells-us-xlii-a-new-view-of-proteins
#18
Michel Morange
No abstract text is available yet for this article.
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28229840/-magnetic-resonance-imaging-conversion-predictors-of-clinically-isolated-syndrome-to-multiple-sclerosis
#19
REVIEW
Sara Peixoto, Pedro Abreu
INTRODUCTION: Clinically isolated syndrome may be the first manifestation of multiple sclerosis, a chronic demyelinating disease of the central nervous system, and it is defined by a single clinical episode suggestive of demyelination. However, patients with this syndrome, even with long term follow up, may not develop new symptoms or demyelinating lesions that fulfils multiple sclerosis diagnostic criteria. We reviewed, in clinically isolated syndrome, what are the best magnetic resonance imaging findings that may predict its conversion to multiple sclerosis...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229511/what-explains-the-correlation-between-growth-in-vocabulary-and-grammar-new-evidence-from-latent-change-score-analyses-of-simultaneous-bilingual-development
#20
Erika Hoff, Jamie M Quinn, David Giguere
A close relationship between children's vocabulary size and the grammatical complexity of their speech is well attested but not well understood. The present study used latent change score modeling to examine the dynamic relationships between vocabulary and grammar growth within and across languages in longitudinal data from 90 simultaneous Spanish-English bilingual children who were assessed at 6-month intervals between 30 and 48 months. Slopes of vocabulary and grammar growth were strongly correlated within each language and showed moderate or nonsignificant relationships across languages...
February 22, 2017: Developmental Science
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