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https://www.readbyqxmd.com/read/29353440/healthy-lifestyle-promotion-in-primary-schools-through-the-board-game-kaledo-a-pilot-cluster-randomized-trial
#1
Emanuela Viggiano, Alessandro Viggiano, Anna Di Costanzo, Adela Viggiano, Andrea Viggiano, Eleonora Andreozzi, Vincenzo Romano, Claudia Vicidomini, Daniela Di Tuoro, Giuliana Gargano, Lucia Incarnato, Celeste Fevola, Pietro Volta, Caterina Tolomeo, Giuseppina Scianni, Caterina Santangelo, Maria Apicella, Roberta Battista, Maddalena Raia, Ilaria Valentino, Marianna Palumbo, Giovanni Messina, Antonietta Messina, Marcellino Monda, Bruno De Luca, Salvatore Amaro
The board game Kaledo was proven to be effective in improving nutrition knowledge and in modifying dietary behavior in students attending middle and high school. The present pilot study aims to reproduce these results in younger students (7-11 years old) attending primary school. A total of 1313 children from ten schools were recruited to participate in the present study. Participants were randomized into two groups: (1) the treatment group which consisted of playing Kaledo over 20 sessions and (2) the no intervention group...
January 20, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29353319/management-strategies-for-noncardiac-surgery-following-a-coronary-artery-event
#2
REVIEW
Thomas F Whayne, Sibu P Saha
PURPOSE OF REVIEW: Coronary artery event includes acute coronary syndrome (ACS), percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) surgery. Following such an event, risk of noncardiac surgery is increased. Of major concern is what can make this surgery safer? RECENT FINDINGS: High functional capacity improves cardiovascular (CV) risk; at least 4.0 metabolic equivalents (METs) on stress test are favorable. Risk scores can suggest need for further evaluation...
January 20, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29352349/factors-affecting-n-terminal-pro-b-type-natriuretic-peptide-levels-in-preterm-infants-and-use-in-determination-of-haemodynamic-significance-of-patent-ductus-arteriosus
#3
Sarah Louise Harris, Kiran More, Bronwyn Dixon, Richard Troughton, Chris Pemberton, John Horwood, Nicola Ellis, Nicola Austin
This study aimed to investigate factors affecting N-terminal pro-B-type natriuretic peptide (NTproBNP) in preterm infants and the ability of NTproBNP to predict haemodynamically significant patent ductus arteriosus (HsPDA). Prospective cohort study of 51 infants < 30 weeks gestation. Blood NTproBNP and heart ultrasound were performed on day of life 3, 10, 28 and 36 weeks corrected age. NTproBNP levels analysed for prediction of HsPDA. The effect of gestational age, ventilation, hypoxia, bronchopulmonary dysplasia (BPD), creatinine and haemoglobin levels on NTproBNP levels were investigated...
January 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29352034/translational-new-approaches-for-investigating-mood-disorders-in-rodents-and-what-they-may-reveal-about-the-underlying-neurobiology-of-major-depressive-disorder
#4
REVIEW
Emma S J Robinson
Mood disorders represent one of society's most costly and challenging health burdens. The drug treatments used today were initially discovered serendipitously in the 1950s. Animal models were then developed based on the ability of these drugs to alter specific behaviours. These models have played a major role in the development of the second generation of antidepressants. However, their use has been heavily criticized, particularly in relation to whether they recapitulate similar underlying biology to the psychiatric disorder they are proposed to represent...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29352022/of-mice-and-mental-health-facilitating-dialogue-and-seeing-further
#5
Amy L Milton, Emily A Holmes
The science of mental life is critical for understanding both how we function, and impairments in our functioning. However, understanding the causal mechanisms underlying mental health disorders and developing new treatments are challenges too great to be solved by any individual approach. There is a growing awareness that translational research-from laboratory to patient and back again to animal models-will be critical for the improved understanding and treatment of mental health disorders. The motivation and intention to pursue translational approaches is therefore strong in mental health research, but critically, opportunities for interaction between basic scientists and clinicians are relatively limited, and vary depending on the institution in which researchers are working...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29351338/stockouts-of-hiv-commodities-in-public-health-facilities-in-kinshasa-barriers-to-end-hiv
#6
Tinne Gils, Claire Bossard, Kristien Verdonck, Philip Owiti, Ilse Casteels, Maria Mashako, Gilles Van Cutsem, Tom Ellman
Stockouts of HIV commodities increase the risk of treatment interruption, antiretroviral resistance, treatment failure, morbidity and mortality. The study objective was to assess the magnitude and duration of stockouts of HIV medicines and diagnostic tests in public facilities in Kinshasa, Democratic Republic of the Congo. This was a cross-sectional survey involving visits to facilities and warehouses in April and May 2015. All zonal warehouses, all public facilities with more than 200 patients on antiretroviral treatment (ART) (high-burden facilities) and a purposive sample of facilities with 200 or fewer patients (low-burden facilities) in Kinshasa were selected...
2018: PloS One
https://www.readbyqxmd.com/read/29351080/ultrastructure-of-digenean-trematode-eggs-platyhelminthes-neoophora-a-review-emphasizing-new-comparative-data-on-four-european-microphalloidea
#7
David Bruce Conn, Zdzisław Świderski, Jordi Miquel
Despite their tremendous diversity and their medical and veterinary importance, details of egg ultrastructure among the digenean trematodes has been studied rather little. The available literature is spread over several decades and several species, but has not been adequately reviewed to reveal patterns of similarity and divergence. We present this review to synthesize and analyse what is known from the available literature reporting studies using both transmission electron microscopy (TEM) and scanning electron microscopy (SEM)...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29350842/from-grey-to-green-efficacy-of-eco-engineering-solutions-for-nature-based-coastal-defence
#8
Rebecca L Morris, Teresa M Konlechner, Marco Ghisalberti, Stephen E Swearer
Climate change is increasing the threat of erosion and flooding along coastlines globally. Engineering solutions (e.g. seawalls and breakwaters) in response to protecting coastal communities and associated infrastructure are increasingly becoming economically and ecologically unsustainable. This has led to recommendations to create or restore natural habitats, such as sand dunes, saltmarsh, mangroves, seagrass and kelp beds, and coral and shellfish reefs, to provide coastal protection in place of (or to complement) artificial structures...
January 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29350546/-we-re-like-a-gang-we-stick-together-experiences-of-ventricular-assist-device-communities
#9
Holly C Standing, Catherine Exley, Guy A MacGowan, Tim Rapley
BACKGROUND: Ventricular assist devices (VADs) are a relatively new development in the management of advanced heart failure. In the UK, VAD recipients comprise a unique group of less than 200 patients. This is the first paper to explore the experience of VAD communities, the extent to which communities are developed around the device, and how these influence the experience of living with the VAD. METHODS: Qualitative interviews were conducted with 20 VAD recipients (implanted as a bridge to transplantation), 11 interviews also included the VAD recipients' partners...
January 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29350495/the-current-landscape-of-3d-in-vitro-tumor-models-what-cancer-hallmarks-are-accessible-for-drug-discovery
#10
REVIEW
Darren Rodenhizer, Teresa Dean, Elisa D'Arcangelo, Alison P McGuigan
Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis, and personal genetics. While investment in research is at an all-time high, new drugs are more likely to fail in clinical trials today than in the 1970s. In this review, a summary of current survival statistics in North America is provided, followed by an overview of the modern drug discovery process, classes of models used throughout different stages, and challenges associated with drug development efficiency are highlighted...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29350333/deltoid-muscle-morphometry-as-an-index-of-impaired-skeletal-muscularity-in-neonatal-intensive-care
#11
Theodore Dassios, Ourania Kaltsogianni, Miltiadis Krokidis, Ann Hickey, Anne Greenough
We hypothesised that extremely premature infants would have decreased muscle mass at term-corrected age compared to term-born infants and that the degree of reduced muscle mass acquisition would correlate with the duration of invasive mechanical ventilation. The MRI brain scans of infants admitted in the neonatal unit at King's College Hospital between 1 January 2010 and 1 June 2016 were retrospectively reviewed. The coronal cross-sectional area of the left deltoid muscle (DCSA) was measured in 17 infants born < 28 weeks of gestation and in 20 infants born at term...
January 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29349866/amorphous-materials-for-enhanced-localized-surface-plasmon-resonances
#12
Chuanhui Zhu, Qun Xu
The discovery of localized surface plasmon resonances (LSPR) in semiconductor nanocrystals has initiated a new field in plasmonics. And plasmonic nanocrystals of crystal materials have gained rapid development in the past years with a class of materials with unique photoelectronic properties. Present now a growing number of amorphous plasmonic materials are steadily capturing scientific interest of people, though only a few are well-characterized. Here, we focus on the recent development in state-of-the art experiments, and explore the vast library of plasmonic properties in amorphous materials, including their application fields and optical spectral range...
January 19, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29349854/implementing-health-and-social-care-integration-in-scotland-renegotiating-new-partnerships-in-changing-cultures-of-care
#13
Charlotte Pearson, Nick Watson
Health and social care integration has been a long-term goal for successive governments in Scotland, culminating in the implementation of the recent Public Bodies (Joint Working) Scotland Act 2014. This laid down the foundations for the delegation of health and social care functions and resources to newly formed Integrated Joint Boards. It put in place demands for new ways of working and partnership planning. In this article, we explore the early implementation of this Act and how health and social care professionals and the third sector have begun to renegotiate their roles...
January 18, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29349524/-qualification-and-classification-of-medical-apps-what-should-be-noted-and-what-is-bfarm-s-contribution
#14
REVIEW
Nicole Rämsch-Günther, Sylvia Stern, Wolfgang Lauer
Smartphones and tablets with their nearly unlimited number of different applications have become an integral part of everyday life. Thus, mobile devices and applications have also found their way into the healthcare sector.For developers, manufacturers, or users as well, it is often difficult to decide whether a mobile health application is a medical device.In this context, it is extremely important for manufacturers to decide at an early stage of the development whether the product is to be introduced into the market as a medical device and is therefore subject to the legislation on medical devices...
January 18, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29349462/self-assembly-of-bis-salphen-compounds-from-semiflexible-chains-to-webs-of-nanorings
#15
Sergey V Pyrlin, Nicholas D M Hine, Arjan W Kleij, Marta M D Ramos
The recently-observed self-assembly of certain salphen-based compounds into neuron-like networks of microrings interconnected with nano-thin strings may suggest a new highly-potent tool for nanoscale patterning. However, the mechanism behind such phenomena needs to be clarified before they can be applied in materials design. Here we show that, in contrast with what was initially presumed, the emergence of a "rings-and-rods" pattern is unlikely to be explained by merging, collapse and piercing of vesicles as in previously reported cases of nanorings self-assembly via non-bonding interactions...
January 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29349099/repetitive-questioning-exasperates-caregivers
#16
R C Hamdy, J V Lewis, R Copeland, A Depelteau, A Kinser, T Kendall-Wilson, K Whalen
Repetitive questioning is due to an impaired episodic memory and is a frequent, often presenting, problem in patients with Alzheimer's disease (amnestic type). It is due to the patients' difficulties learning new information, retaining it, and recalling it, and is often aggravated by a poor attention span and easy distractibility. A number of factors may trigger and maintain repetitive questioning. Caregivers should try to identify and address these triggers. In the case discussion presented, it is due to the patient's concerns about her and her family's safety triggered by watching a particularly violent movie aired on TV...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29348444/toxicdocs-www-toxicdocs-org-from-history-buried-in-stacks-of-paper-to-open-searchable-archives-online
#17
EDITORIAL
David Rosner, Gerald Markowitz, Merlin Chowkwanyun
As a result of a legal mechanism called discovery, the authors accumulated millions of internal corporate and trade association documents related to the introduction of new products and chemicals into workplaces and commerce. What did these private entities discuss among themselves and with their experts? The plethora of documents, both a blessing and a curse, opened new sources and interesting questions about corporate and regulatory histories. But they also posed an almost insurmountable challenge to historians...
February 2018: Journal of Public Health Policy
https://www.readbyqxmd.com/read/29348120/apoc3-loss-of-function-mutations-remnant-cholesterol-low-density-lipoprotein-cholesterol-and-cardiovascular-risk-mediation-and-meta-analyses-of-137-895-individuals
#18
Anders B Wulff, Børge G Nordestgaard, Anne Tybjærg-Hansen
OBJECTIVE: Loss-of-function mutations in APOC3 associate with low remnant cholesterol levels and low risk of ischemic vascular disease (IVD). Because some studies show an additional association with low levels of low-density lipoprotein cholesterol (LDL-C), low LDL-C may explain the low risk of IVD in APOC3 loss-of-function heterozygotes. We tested to what extent the low risk of IVD in APOC3 loss-of-function heterozygotes is mediated by low plasma remnant cholesterol and LDL-C. APPROACH AND RESULTS: In APOC3 loss-of-function heterozygotes versus noncarriers, we first determined remnant cholesterol and LDL-C levels in meta-analyses of 137 895 individuals...
January 18, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29347910/getting-messier-with-tidier-embracing-context-and-complexity-in-intervention-reporting
#19
Sarah Cotterill, Sarah Knowles, Anne-Marie Martindale, Rebecca Elvey, Susan Howard, Nia Coupe, Paul Wilson, Michael Spence
BACKGROUND: The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is now widely used in health research. The aim of this paper is to describe the experience of using TIDieR outside of trials, in a range of applied health research contexts, and make recommendations on its usefulness in such settings. MAIN BODY: We used the TIDieR template for intervention description in six applied health research projects...
January 18, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29347858/where-are-we-with-injectables-against-hiv-infection-and-what-are-the-remaining-challenges
#20
Said A Hassounah, Thibault Mesplède
Drug adherence has been a recurring issue in the field of HIV treatment, and low treatment adherence is typically associated with emergence of drug resistance, treatment failure and increased risks of transmission. Injectable antiretroviral drugs offer a unique opportunity to counter this issue for the treatment of HIV-positive individuals. In addition, injectables offer a remarkable opportunity to reduce new HIV infections, if applied in the context of both treatment-as-prevention and pre-exposure prophylaxis...
January 19, 2018: Expert Review of Anti-infective Therapy
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