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https://www.readbyqxmd.com/read/28830137/clinical-applications-of-interferon-%C3%AE-releasing-assays-for-cytomegalovirus-to-differentiate-cytomegalovirus-disease-from-bystander-activation-a-pilot-proof-of-concept-study
#1
Sung-Han Kim, Ho-Su Lee, Hyun-Jung Lee, Sun-Mi Kim, Sung Shin, Sang-Hyoung Park, Kyung-Jo Kim, Young-Hoon Kim, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Suk-Kyun Yang, Yang Soo Kim, Jun Hee Woo, Duck-Jong Han
Background/Aims: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models. Methods: We prospectively enrolled all human immunodeficiency virus non-infected patients with confirmed Pneumocystitis jirovecii pneumonia (PCP) and those with suspected gastrointestinal CMV disease in a tertiary hospital. All patients underwent CMV interferon-γ releasing assay (IGRA) for CMV (T-track CMV, Lophius Biosciences)...
August 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28830135/clinical-interpretation-of-elevated-ca-19-9-levels-in-obstructive-jaundice-following-benign-and-malignant-pancreatobiliary-disease
#2
Min Seong Kim, Tae Joo Jeon, Ji Young Park, Jeongmin Choi, Won Chang Shin, Seong Eun Park, Ji Young Seo, Young Moon Kim
Background/Aims: Elevated carbohydrate antigen (CA) 19-9 level may be unable to differentiate between benign and malignant pancreatobiliary disease with obstructive jaundice. The study aims to determine the clinical interpretation and the diagnostic value of CA 19-9 level in pancreatobiliary diseases with coexistent obstructive jaundice. Methods: We retrospectively reviewed the data of 981 patients who underwent biliary drainage due to obstructive jaundice following pancreatobiliary disease at Sanggye Paik Hospital for 5 years...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830134/split-dose-bowel-preparation-for-colonoscopy-2-liters-polyethylene-glycol-with-ascorbic-acid-versus-sodium-picosulfate-versus-oral-sodium-phosphate-tablets
#3
Seok Won Lee, Chang Seok Bang, Tae Young Park, Ki Tae Suk, Gwang Ho Baik, Dong Joon Kim
Background/Aims: Adequate bowel preparation is an essential factor affecting the visibility of colonic mucosa and safety of related therapeutic interventions. The aim of this study was to assess the efficacy, tolerability, and safety of three bowel preparation agents -2 L polyethylene glycol with ascorbic acid (PEGA), sodium picosulfate magnesium citrate (SPMC), and oral sodium phosphate tablet (NaP)- for morning colonoscopy. Methods: Here, we analyzed the medical records of patients who had taken bowel preparation agents using the split-dose method and undergone colonoscopy in a single hospital...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830119/confirmation-of-carfentanil-u-47700-and-other-synthetic-opioids-in-a-human-performance-case-by-lc-ms-ms
#4
Joshua Seither, Lisa Reidy
Recently, it has been documented that there has been a rise in synthetic opioid abuse. Synthetic opioids are compounds that were created to act as agonists for the opioid receptors. Like synthetic cannabinoids, most of these compounds were created by research groups or pharmaceutical companies in an attempt to find compounds that have medicinal use. Synthetic opioids have severe health implications when abused that can include hospitalization and death. Due to the high potency and the low dose required to produce the desired effects for these compounds, it was hypothesized that they may not be detectable in human performance case samples...
July 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28830110/elucidating-transmission-patterns-from-internet-reports-ebola-and-middle-east-respiratory-syndrome-as-case-studies
#5
Gerardo Chowell, Julie M Cleaton, Cecile Viboud
The paucity of traditional epidemiological data during epidemic emergencies calls for alternative data streams to characterize the key features of an outbreak, including the nature of risky exposures, the reproduction number, and transmission heterogeneities. We illustrate the potential of Internet data streams to improve preparedness and response in outbreak situations by drawing from recent work on the 2014-2015 Ebola epidemic in West Africa and the 2015 Middle East respiratory syndrome (MERS) outbreak in South Korea...
December 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28830083/metoprolol-increases-uric-acid-and-risk-of-gout-in-african-americans-with-chronic-kidney-disease-attributed-to-hypertension
#6
Stephen P Juraschek, Lawrence J Appel, Edgar R Miller
BACKGROUND: There is little evidence guiding selection of nondiuretic, antihypertensive agents with a goal of lowering uric acid (SUA) and minimizing gout risk. METHODS: In the African American Study of Kidney Disease and Hypertension (AASK) trial, African Americans with chronic kidney disease were randomly assigned to metoprolol (a beta-blocker), ramipril (an angiotensin-converting enzyme inhibitors [ACEi]), or amlodipine (a dihydropyridine calcium-channel blocker)...
September 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28830022/measurement-of-43-sc-and-44-sc-production-cross-section-with-an-18mev-medical-pet-cyclotron
#7
Tommaso Stefano Carzaniga, Martin Auger, Saverio Braccini, Maruta Bunka, Antonio Ereditato, Konrad Pawel Nesteruk, Paola Scampoli, Andreas Türler, Nicholas van der Meulen
(43)Sc and (44)Sc are positron emitter radionuclides that, in conjunction with the β(-) emitter (47)Sc, represent one of the most promising possibilities for theranostics in nuclear medicine. Their availability in suitable quantity and quality for medical applications is an open issue and their production with medical cyclotrons represents a scientific and technological challenge. For this purpose, an accurate knowledge of the production cross sections is mandatory. In this paper, we report on the cross section measurement of the reactions (43)Ca(p,n)(43)Sc, (44)Ca(p,2n) (43)Sc, (46)Ti(p,α)(43)Sc, and (44)Ca(p,n)(44)Sc at the Bern University Hospital cyclotron...
August 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28829976/nation-wide-trends-in-non-alcoholic-steatohepatitis-nash-in-patients-with-and-without-diabetes-between-2004-05-and-2014-15-in-england
#8
Jack E Carruthers, Alex Bottle, Anthony A Laverty, Shahid A Khan, Christopher Millett, Eszter P Vamos
AIMS: There are no national studies evaluating the epidemiology of non-alcoholic steatohepatitis (NASH) in England. NASH is becoming an increasingly important health issue given the inexorable rise in obesity and diabetes. We evaluated the rates of NASH in people with and without diabetes from 2004-2005 to 2014-2015. METHODS: We identified cases of biopsy-proven NASH in people with and without diabetes in England over an eleven-year period using Hospital Episode Statistics...
July 29, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28829974/nurses-personal-and-ward-accountability-and-missed-nursing-care-a-cross-sectional-study
#9
Einav Srulovici, Anat Drach-Zahavy
BACKGROUND: Missed nursing care is considered an act of omission with potentially detrimental consequences for patients, nurses, and organizations. Although the theoretical conceptualization of missed nursing care specifies nurses' values, attitudes, and perceptions of their work environment as its core antecedents, empirical studies have mainly focused on nurses' socio-demographic and professional attributes. Furthermore, assessment of missed nursing care has been mainly based on same-source methods...
August 16, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28829973/feasibility-and-efficacy-of-repeated-hysteroscopic-cesarean-niche-resection
#10
Shlomo B Cohen, Roy Mashiach, Alexandra Baron, Motti Goldenberg, Eyal Schiff, Raoul Orvieto, Jerome Bouaziz
OBJECTIVE: Cesarean-induced niche can cause symptoms such as abnormal postmenstrual bleeding, pain and associated infertility. Hysteroscopic niche resection is usually a successful treatment, but can result in a failure to improve symptoms or symptoms can recur. In the present study we aim to evaluate the feasibility, effectiveness, and safety of a second hysteroscopic niche resection for patients in whom an initial hysteroscopic resection failed to improve symptoms. STUDY DESIGN: This retrospective cohort study (Canadian Task Force classification II-2) hospital tell hashomer (tertiary center) included all patients who underwent a second hysteroscopic niche resection between 2011 and 2015...
August 12, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28829927/solo-surgeon-single-port-laparoscopic-anterior-resection-for-sigmoid-colon-cancer-comparative-study
#11
Byung Jo Choi, Won Jun Jeong, Say-June Kim, Sang Chul Lee
BACKGROUND: To report our experience with solo-surgeon, single-port laparoscopic anterior resection (solo SPAR) for sigmoid colon cancer. MATERIALS AND METHODS: Data from sigmoid colon cancer patients who underwent anterior resections (ARs) using the single-port, solo surgery technique (n = 31) or the conventional single-port laparoscopic technique (n = 45), between January 2011 and July 2016, were retrospectively analyzed. In the solo surgeries, making the transumbilical incision into the peritoneal cavity was facilitated through the use of a self-retaining retractor system...
August 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28829925/aya-myeloma-real-world-single-center-experience-over-last-5-years
#12
Uday Yanamandra, Neha Saini, Pooja Chauhan, Tanya Sharma, Alka Khadwal, Gaurav Prakash, Neelam Varma, Deepesh Lad, Subhash Varma, Pankaj Malhotra
INTRODUCTION: Multiple myeloma (MM) is considered as a disease of the old with the reported median age of 60-70 years. The disease occurred a decade earlier in the Indian subcontinent. The literature on MM in adolescents and young adult (AYA) is limited. We studied the disease characteristics and outcomes of the AYA-MM in the real-world setting. PATIENTS AND METHODS: It is a retrospective single-center study conducted at a tertiary care center from North India. Records of all consecutive patients with AYA-MM (15-39 years of age) who were managed from January 1, 2010, to December 30, 2015, were reviewed...
August 22, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28829905/polymorphisms-of-interleukin-6-in-down-syndrome-individuals-a-case-control-study
#13
M F Mattos, L Uback, P M Biselli-Chicote, J M Biselli, E M Goloni-Bertollo, E C Pavarino
Down syndrome (DS) individuals present impaired adaptive immune system. However, the etiology of the immunological deficiency in these individuals is not completely understood. This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome. The study included 282 individuals, 94 with DS attended at the General Genetics Outpatient Service of Hospital de Base, São José do Rio Preto, SP, Brazil, and 188 individuals without DS attended at the Pediatric Service of Hospital de Base de São José do Rio Preto, SP, Brazil...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829877/effect-of-ganciclovir-on-il-6-levels-among-cytomegalovirus-seropositive-adults-with-critical-illness-a-randomized-clinical-trial
#14
Ajit P Limaye, Renee D Stapleton, Lili Peng, Scott R Gunn, Louise E Kimball, Robert Hyzy, Matthew C Exline, D Clark Files, Peter E Morris, Stephen K Frankel, Mark E Mikkelsen, Duncan Hite, Kyle B Enfield, Jay Steingrub, James O'Brien, Polly E Parsons, Joseph Cuschieri, Richard G Wunderink, David L Hotchkin, Ying Q Chen, Gordon D Rubenfeld, Michael Boeckh
Importance: The role of cytomegalovirus (CMV) reactivation in mediating adverse clinical outcomes in nonimmunosuppressed adults with critical illness is unknown. Objective: To determine whether ganciclovir prophylaxis reduces plasma interleukin 6 (IL-6) levels in CMV-seropositive adults who are critically ill. Design, Setting, and Participants: Double-blind, placebo-controlled, randomized clinical trial (conducted March 10, 2011-April 29, 2016) with a follow-up of 180 days (November 10, 2016) that included 160 CMV-seropositive adults with either sepsis or trauma and respiratory failure at 14 university intensive care units (ICUs) across the United States...
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28829876/effect-of-natriuretic-peptide-guided-therapy-on-hospitalization-or-cardiovascular-mortality-in-high-risk-patients-with-heart-failure-and-reduced-ejection-fraction-a-randomized-clinical-trial
#15
G Michael Felker, Kevin J Anstrom, Kirkwood F Adams, Justin A Ezekowitz, Mona Fiuzat, Nancy Houston-Miller, James L Januzzi, Daniel B Mark, Ileana L Piña, Gayle Passmore, David J Whellan, Hongqiu Yang, Lawton S Cooper, Eric S Leifer, Patrice Desvigne-Nickens, Christopher M O'Connor
Importance: The natriuretic peptides are biochemical markers of heart failure (HF) severity and predictors of adverse outcomes. Smaller studies have evaluated adjusting HF therapy based on natriuretic peptide levels ("guided therapy") with inconsistent results. Objective: To determine whether an amino-terminal pro-B-type natriuretic peptide (NT-proBNP)-guided treatment strategy improves clinical outcomes vs usual care in high-risk patients with HF and reduced ejection fraction (HFrEF)...
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28829829/intermediate-cd14-cd16-monocytes-decline-after-transcatheter-aortic-valve-replacement-and-correlate-with-functional-capacity-and-left-ventricular-systolic-function
#16
Jonas Neuser, Paolo Galuppo, Daniela Fraccarollo, Jens Willig, Tibor Kempf, Dominik Berliner, Johann Bauersachs, Julian Daniel Widder
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is the method of choice for patients with severe aortic valve stenosis, who are ineligible or at high risk for surgery. Though TAVR leads to a significant reduction in mortality, a notable amount of patients are re-hospitalized early after TAVR. Parameters or biomarkers predicting outcome are therefore needed to identify patients who benefit most. Specific monocyte subsets have been associated with cardiovascular diseases and were shown to possess prognostic value...
2017: PloS One
https://www.readbyqxmd.com/read/28829828/choosing-the-right-rehabilitation-setting-after-herniated-disc-surgery-motives-motivations-and-expectations-from-the-patients-perspective
#17
Margrit Löbner, Janine Stein, Melanie Luppa, Alexander Konnopka, Hans Jörg Meisel, Lutz Günther, Jürgen Meixensberger, Katarina Stengler, Matthias C Angermeyer, Hans-Helmut König, Steffi G Riedel-Heller
OBJECTIVES: This study aims to investigate (1) motives, motivations and expectations regarding the choice for a specific rehabilitation setting after herniated disc surgery and (2) how rehabilitation-related motivations and expectations are associated with rehabilitation outcome (ability to work, health-related quality of life and satisfaction with rehabilitation) three months after disc surgery. METHODS: The longitudinal cohort study refers to 452 disc surgery patients participating in a subsequent rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28829826/elevated-neutrophil-to-lymphocyte-ratio-and-ischemic-stroke-risk-in-generally-healthy-adults
#18
Beomseok Suh, Dong Wook Shin, Hyung-Min Kwon, Jae Moon Yun, Hyung-Kook Yang, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho
Elevated neutrophil to lymphocyte ratio (NLR) has been reported as a marker for chronic inflammation, associated with poor prognosis in ischemic stroke patients, but there has been no study that investigated its association with ischemic stroke risk. This study was conducted to investigate elevated NLR as an independent risk factor for ischemic stroke incidence. Our retrospective cohort study included 24,708 generally healthy subjects aged 30-75 who received self-referred health screening at Seoul National University Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28829801/evaluating-quality-management-systems-for-hiv-rapid-testing-services-in-primary-healthcare-clinics-in-rural-kwazulu-natal-south-africa
#19
Ziningi Jaya, Paul K Drain, Tivani P Mashamba-Thompson
INTRODUCTION: Rapid HIV tests have improved access to HIV diagnosis and treatment by providing quick and convenient testing in rural clinics and resource-limited settings. In this study, we evaluated the quality management system for voluntary and provider-initiated point-of-care HIV testing in primary healthcare (PHC) clinics in rural KwaZulu-Natal (KZN), South Africa. MATERIAL AND METHODS: We conducted a quality assessment audit in eleven PHC clinics that offer voluntary HIV testing and counselling in rural KZN, South Africa from August 2015 to October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28829792/effect-of-endurance-exercise-on-micrornas-in-myositis-skeletal-muscle-a-randomized-controlled-study
#20
Jessica F Boehler, Marshall W Hogarth, Matthew D Barberio, James S Novak, Svetlana Ghimbovschi, Kristy J Brown, Li Alemo Munters, Ingela Loell, Yi-Wen Chen, Heather Gordish-Dressman, Helene Alexanderson, Ingrid E Lundberg, Kanneboyina Nagaraju
OBJECTIVE: To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients. METHODS: Following a parallel clinical trial design, patients with probable PM or DM, exercising less than once a week, and on stable medication for at least one month were randomized into two groups at Karolinska University Hospital: a 12-week endurance exercise group (n = 12) or a non-exercised control group (n = 11)...
2017: PloS One
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