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https://www.readbyqxmd.com/read/29055287/efficacy-and-tolerability-of-high-dose-pelargonium-extract-in-patients-with-the-common-cold
#1
David S Riley, Viktor G Lizogub, Andrea Zimmermann, Petra Funk, Walter Lehmacher
Context • The common cold (CC) is usually caused by a viral infection. Antibiotics are often prescribed unnecessarily for it, although no evidence exists for any benefit in the CC. Effective alternatives are needed. Objective • The study intended to evaluate the efficacy of 7630, a proprietary extract of Pelargonium sidoides, the active ingredient in umckaloabo, compared with a placebo for the treatment of the CC. Design • This was a prospective, double-blind, parallel-group, placebo-controlled, phase 3 clinical trial (RCT), with an adaptive group-sequential design with 2 parts, both of which were 2-arm trials...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055285/delayed-spontaneous-resorption-of-lumbar-intervertebral-disc-herniation-a-case-report
#2
You Jin Jung, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, In-Hyuk Ha
Background • Large intervertebral disc herniation is often managed with surgery, but it is not uncommon for spontaneous resorption of herniated disc material to occur. Although the majority of spontaneous disc resorption occurs in the acute phase, an unusual case of delayed intervertebral disc regression at 18 mo postonset is presented. Case Presentation • A 32-y-old female patient presented with acute low-back pain and pain in both legs a Korean medicine hospital specializing in spinal disorders. Massive intervertebral disc herniation was found on lumbar magnetic resonance imaging (MRI), and inguinal and genital pain and numbness was suggestive of risk of cauda equina syndrome...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055263/sub-cortical-brain-morphometry-and-its-relationship-with-cognition-in-rolandic-epilepsy
#3
Mahsa Shakeri, Alexandre N Datta, Domitille Malfait, Nadine Oser, Laurent Létourneau-Guillon, Philippe Major, Myriam Srour, Alan Tucholka, Samuel Kadoury, Sarah Lippé
PURPOSE: Rolandic epilepsy (RE), also called benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome. RE is associated with cognitive difficulties, which can affect children's quality of life. The underlying causes of these cognitive impairments are unclear. The objective of this prospective study is to investigate sub-cortical morphological alterations in RE children with left, right, or bilateral hemispheric focus and its association with cognition...
October 7, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29055259/functional-impairment-in-adult-bipolar-disorder-with-adhd
#4
Imma Torres, Marina Garriga, Brisa Sole, Caterina M Bonnín, Montse Corrales, Esther Jiménez, Eva Sole, Josep A Ramos-Quiroga, Eduard Vieta, Jose M Goikolea, Anabel Martínez-Aran
BACKGROUND: It is well established that patients with either bipolar disorder (BD) or attention-deficit/hyperactivity disorder (ADHD) present functional impairment even when in remission. Nevertheless, research on functional impairment with adult patients with bipolar disorder comorbid to ADHD (BD+ADHD) is very scarce. The main objective of the current report was to evaluate the overall and specific domains of functioning, in patients with BD+ADHD compared to patients with pure bipolar disorder (pBD) and healthy controls (HCs)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055221/cage-with-anterior-plating-is-advantageous-over-the-stand-alone-cage-for-segmental-lordosis-in-the-treatment-of-two-level-cervical-degenerative-spondylopathy-a-retrospective-study
#5
Paolo Perrini, Federico Cagnazzo, Nicola Benedetto, Riccardo Morganti, Carlo Gambacciani
OBJECTIVES: To compare retrospectively the clinical and radiological outcomes in cervical spinal alignment after two consecutive levels PEEK cage-assisted ACDF when performed with or without plate fixation PATIENTS AND METHODS: Seventy-eight patients underwent two consecutive levels PEEK cage-assisted ACDF without plating (56 patients) or supplemented with plating (22 patients). The average clinical follow-up was 31.40±12.98months. The authors compared clinical parameters (Neck disability index and Robinson criteria), perioperative parameters (hospital stays, complications), and radiological parameters (global lordotic curvature, segmental lordosis, segmental height)...
October 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29055181/pfa-100-measured-aspirin-resistance-is-the-predominant-risk-factor-for-hospitalized-cardiovascular-events-in-aspirin-treated-patients-a-5-year-cohort-study
#6
H Y Chen, P Chou
WHAT IS KNOWN AND OBJECTIVE: Aspirin therapy is the clinical gold standard for the prevention of cardiovascular events. However, cardiovascular events still develop in some patients undergoing aspirin therapy. Many laboratory methods exist for measuring aspirin resistance. Using the platelet Function Analyzer (PFA)-100 system, we aimed to determine the effect of aspirin resistance on hospitalized cardiovascular events (hCVE) in a 5-year follow-up cohort. We also sought to determine the impact of aspirin resistance on the relationship between common cardiovascular risk factors and cardiovascular hospitalization...
October 21, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29055148/trends-in-healthcare-costs-and-utilization-for-inflammatory-bowel-disease-from-2010-to-2014-in-korea-a-nationwide-population-based-study
#7
Jung-Wook Kim, Chang Kyun Lee, Sang Youl Rhee, Chi Hyuck Oh, Jae-Jun Shim, Hyo Jong Kim
BACKGROUND AND AIMS: Data regarding healthcare costs and utilization for IBD at the population level are limited in Asia. We aimed to investigate the nationwide prevalence, and healthcare cost and utilization of IBD in Korea. METHODS: We tracked the IBD-attributable healthcare costs and utilization from 2010 to 2014 using the public dataset obtained from Korean National Health Insurance Service claims. We estimated the nationwide prevalence of IBD using population census data from Statistics Korea during the same period...
October 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29055145/positive-predictive-values-of-peripheral-arterial-and-venous-thrombosis-codes-in-french-hospital-database
#8
Mandy Prat, Hélène Derumeaux, Laurent Sailler, Maryse Lapeyre-Mestre, Guillaume Moulis
French hospital database, called Programme de Médicalisation des Systèmes d'Information (PMSI) covers all hospitals stays in France (>66 million inhabitants). The aim of this study was to estimate the positive predictive values (PPVs) of primary diagnosis codes of peripheral arterial and venous thrombosis codes in the PMSI, encoded with the International Classification of Diseases, 10(th) revision. Data were extracted from the PMSI database of Toulouse University Hospital, South of France. We identified all the hospital stays in 2015 with a code of peripheral arterial or venous thrombosis as primary diagnosis...
October 21, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29055130/randomized-trial-of-combined-cabergoline-and-coasting-in-preventing-ovarian-hyperstimulation-syndrome-during-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles
#9
Yasmin A Bassiouny, Dina M R Dakhly, Yomna A Bayoumi, Noha M Salaheldin, Hisham M Gouda, Ayman A Hassan
OBJECTIVE: To assess the efficacy of coasting alone, cabergoline alone, or combining both interventions for preventing ovarian hyperstimulation syndrome (OHSS) among high-risk patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles. METHODS: The present randomized controlled trial was conducted at the IVF unit of a university hospital in Cairo between October 28, 2013, and July 31, 2015. Patients undergoing IVF/ICSI considered at risk of OHSS were randomly allocated to coasting, cabergoline, or combined coasting and cabergoline...
October 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29055109/endoscopic-reduction-of-gastric-antrum-herniation-through-the-foramen-of-winslow-into-the-lesser-sac
#10
Cheal Wung Huh, Joon Sung Kim, Byung-Wook Kim
A 67-years-old woman visited our hospital because of abdominal distension and vomiting. Upper gastrointestinal series (UGI) showed diffuse stomach dilatation with no contrast passage (Fig. 1a). Abdominal computed tomography(CT) scan revealed entrapment of the antrum and converging mesenteric vessels into the lesser sac through Winslow's foramen without evidence of bowel necrosis or strangulation (Fig. 1b). This article is protected by copyright. All rights reserved.
October 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29055054/a-multicenter-prospective-evaluation-study-of-endoscopic-ultrasound-guided-hepaticogastrostomy-combined-with-antegrade-stenting-with-video
#11
Takeshi Ogura, Masayuki Kitano, Mamoru Takenaka, Atsushi Okuda, Kosuke Minaga, Kentaro Yamao, Yukitaka Yamashita, Keiichi Hatamaru, Chishio Noguchi, Yasuhiko Gotoh, Taira Kuroda, Tomoyuki Yokota, Hidefumi Nishikiori, Ryota Sagami, Kazuhide Higuchi, Yasutaka Chiba
OBJECTIVE: EUS-guided hepaticogastrostomy (EUS-HGS) is often indicated for advanced stage patients because it prevents the adverse events associated with EUS-HGS procedures, and provides long stent patency. EUS-guided antegrade stenting (AS) has been developed as an advanced technique. Thus, to prevent adverse events and achieve, long stent patency, EUS-AS combined with EUS-HGS (EUS-HGAS) has been reported. The aim of this study was to evaluate the technical feasibility and efficacy of EUS-HGAS in a multicenter, prospective study...
October 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29054939/result-of-health-illiteracy-and-cultural-stigma-fournier-s-gangrene-a-urological-emergency
#12
Manasi Jiwrajka, Krishan Pratap, William Yaxley, Nigel Dunglison
A 63-year-old Caucasian man presents to his regional hospital 8 days postinsertion of beads in his urethra, causing Fournier's gangrene of the penis and delayed surgical management of his gangrene. The reasons for his delay are cultural stigma associated with sexual practices and health illiteracy.
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054935/familial-history-aggregation-on-acute-appendicitis
#13
Francesc Simó Alari, Israel Gutierrez, Judit Gimenéz Pérez
Appendectomy is the most commonly performed surgical procedure, affecting 1%-8% of the paediatric population, with a total 7% lifetime risk, most likely in adolescents and young adults.A case of familial aggregation was reported in our hospital in a family composed of nine siblings from which six of them (66.6%) had been treated of acute appendicitis, five of them in our centre.Many factors have been described as predisposing to appendicitis. Several studies have highlighted the influence of genes in the evolution of this disease and its severity, demonstrating a relative risk increase by three when family history is present...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054932/improving-paediatric-residents-knowledge-and-perspectives-regarding-the-insulin-pump-using-a-novel-educational-workshop
#14
Shipra Bansal, Albara Marwa, Kannan Kasturi, Sheila Perez-Colon
OBJECTIVES: As a pilot study, we aimed to investigate the knowledge and perceptions of categorical paediatric residents (RES) at our institution regarding insulin pumps (IPs) and the impact following a targeted workshop. METHODS: All RES at our institution in attendance at a routine noon conference participated in a workshop, completing an anonymous survey before and right after the intervention to evaluate knowledge, attitudes and self-reported comfort regarding IPs...
October 20, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29054907/secondary-aortoduodenal-fistula-and-the-unrecognised-herald-bleed
#15
Francesc Simó Alari, Esther Molina González, Israel Gutierrez, Aïcha Ahamdanech-Idrissi
A 65-year-old man with history of aortobifemoral surgery 4 years ago was admitted to hospital after sudden abdominal pain. Initially misdiagnosed as renal colic, he was treated with analgesics, and while on observation he started with haematemesis, rapidly responding to volume infusion. Upper gastrointestinal endoscopy showed fresh blood in the stomach with no visible active bleeding. CT scan showed an important contrast extravasation from the aorta to the third duodenal portion, restarting haemodynamic instability and a cardiac arrest...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054892/transthoracic-littre-s-hernia-presenting-with-faecopneumothorax-following-perforation-of-the-meckel-s-diverticulum-a-late-complication-of-oesophagectomy
#16
Charles West, Karen Erskine, Khaled Hamdan
A Littre's hernia is an unusual phenomenon where a Meckel's diverticulum protrudes through a potential abdominal opening. We wish to present a unique case of a 79-year-old man with respiratory distress following a fall from standing, initially managed as a haemothorax. After a chest drain was placed, bowel contents were drained from the pleural cavity and he was taken to theatre. He had a history of minimally invasive oesophagectomy for cancer and had subsequently developed a diaphragmatic hernia. A blind ending diverticulum with a perforation at its tip was found in the left oblique lung fissure that was subsequently confirmed histologically as a perforated Meckel's diverticulum...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054842/acute-biventricular-mechanical-circulatory-support-for-cardiogenic-shock
#17
Sudeep Kuchibhotla, Michele L Esposito, Catalina Breton, Robert Pedicini, Andrew Mullin, Ryan O'Kelly, Mark Anderson, Dennis L Morris, George Batsides, Danny Ramzy, Mark Grise, Duc Thinh Pham, Navin K Kapur
BACKGROUND: Biventricular failure is associated with high in-hospital mortality. Limited data regarding the efficacy of biventricular Impella axial flow catheters (BiPella) support for biventricular failure exist. The aim of this study was to explore the clinical utility of percutaneously delivered BiPella as a novel acute mechanical support strategy for patients with cardiogenic shock complicated by biventricular failure. METHODS AND RESULTS: We retrospectively analyzed data from 20 patients receiving BiPella for biventricular failure from 5 tertiary-care hospitals in the United States...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054833/pregnant-women-s-perceptions-of-the-risks-and-benefits-of-disclosure-during-web-based-mental-health-e-screening-versus-paper-based-screening-randomized-controlled-trial
#18
Dawn Kingston, Anne Biringer, Sander Veldhuyzen van Zanten, Rebecca Giallo, Sarah McDonald, Glenda MacQueen, Lydia Vermeyden, Marie-Paule Austin
BACKGROUND: Pregnant women's perceptions of the risks and benefits during mental health screening impact their willingness to disclose concerns. Early research in violence screening suggests that such perceptions may vary by mode of screening, whereby women view the anonymity of e-screening as less risky than other approaches. Understanding whether mode of screening influences perceptions of risk and benefit of disclosure is important in screening implementation. OBJECTIVE: The objective of this randomized controlled trial was to compare the perceptions of pregnant women randomized to a Web-based screening intervention group and a paper-based screening control group on the level of risk and benefit they perceive in disclosing mental health concerns to their prenatal care provider...
October 20, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29054777/hidden-blood-loss-in-anterior-cervical-fusion-surgery-an-analysis-of-risk-factors
#19
Longfei Wen, Daxiang Jin, Weixing Xie, Yue Li, Weijian Chen, Shuncong Zhang, Xiaobing Jiang
STUDY DESIGN: a retrospective study. OBJECTIVES: Anterior cervical fusion surgery is widely used procedure in cervical spondylosis. When considering the blood re-infusion strategies of cervical fusion surgery, the amount of blood loss is one of the key element. We usually calculate the blood loss according to the surgical bleeding plus the postoperative drainage; however, it ignored the possibility that there may be a partly amount of hidden blood loss. METHODS: We performed a retrospective study to determine the risk factors for HBL in patients underwent anterior cervical fusion surgery for degenerative spine from 2013 to 2016...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054772/through-clinical-observation-the-history-of-priapism-after-spinal-cord-injuries
#20
REVIEW
Mihaela Dana Turliuc, Serban Turliuc, Andrei Ionut Cucu, Camelia Tamas, Alexandru Carauleanu, Catalin Buzduga, Anca Sava, Gabriela Florenta Dumitrescu, Claudia Florida Costea
Since ancient times, the physicians of Antiquity noted the occurrence of priapism in some spinal cord injuries. Although priests saw it as a consequence of curses and witchcraft, after clinical observations of the Middle Ages and Renaissance, first medical hypotheses emerged in the 17(th)-19(th) centuries completed and argued by neuroscience and neurology developed in the European laboratories and hospitals. This study aims to present a short overview of the history of clinical observations of posttraumatic male priapism after spinal cord injuries since Antiquity until the beginning of the 20(th) century...
October 17, 2017: World Neurosurgery
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