keyword
https://read.qxmd.com/read/38501690/molecularly-defined-thoracic-neoplasms
#21
JOURNAL ARTICLE
Anja C Roden
Molecularly defined neoplasms are increasingly recognized, given the broader application and performance of molecular studies. These studies allow us to better characterize these neoplasms and learn about their pathogenesis. In the thorax, molecularly defined neoplasms include tumors such as NUT carcinoma, SMARCA4-deficient undifferentiated tumor (DUT), primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms. Overall, these tumors are rare but are now more often recognized given more widely available immunostains such as NUT (NUT carcinoma), BRG1 (SMARCA4-DUT), and INI-1 (SMARCB1-deficient neoplasm)...
March 19, 2024: Advances in Anatomic Pathology
https://read.qxmd.com/read/38498999/the-role-of-neutrophil-lymphocytes-ratio-nlr-in-the-prognosis-of-cin2-2-recurrence-after-excisional-treatment
#22
JOURNAL ARTICLE
Mattia Dominoni, Amelia Barcellini, Marianna Francesca Pasquali, Annalisa De Silvestri, Virginia Valeria Ferretti, Stefania Cesari, Giacomo Fiandrino, Ester Orlandi, Barbara Gardella
The main risk factor involved in CIN2+ recurrence after treatment is the HPV persistent infection. The dysregulation of the immune system permits only HR-HPVs to become persistent infections, to promote cancer development and to increase the risk of recurrence after treatment. Therefore, there is a shift to a Th2-type cytokine pattern during the carcinogenesis pathway; for this reason, the neutrophil-lymphocytes ratio (NLR) could be a marker of this immunological change. The study aims to analyse the predictive role of NLR in the recurrence of High-grade CIN (CIN2+) after excisional treatment in a real-world life setting of patients treated for CIN2+ Design: cross-sectional study Participants/Materials, Setting, Methods: We examined a retrospective database of 444 patients, who attended the Colposcopy Service of our Department from 2011 to 2020 due to an abnormal screening pap smear and we compared the clinical characteristics to NLR performed at the time of diagnosis...
March 18, 2024: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/38496134/a-case-of-autoimmune-pulmonary-alveolar-proteinosis-with-predominantly-peripheral-opacities-diagnosed-by-transbronchial-lung-biopsy
#23
Takeshi Imakura, Soji Kakiuchi, Mami Inayama, Ayaka Mori, Takashi Haku
Although pulmonary alveolar proteinosis (PAP) showed various shadows, its shadows are usually distributed predominantly in the central lung area. We report a case of autoimmune PAP with localized subpleural ground-glass shadows in the bilateral upper lobes, which was diagnosed based on transbronchial lung biopsy (TBLB) specimen findings and anti-granulocyte macrophage colony PAP stimulating factor antibody positivity. PAP should be listed as a differential diagnosis for subpleural shadows. If subpleural shadows are observed, TBLB should be performed aggressively, and anti-granulocyte macrophage colony-stimulating factor (anti-GM-CSF) antibodies should be submitted...
February 2024: Curēus
https://read.qxmd.com/read/38487678/fibrinolysis-biomarker-thrombin-and-activated-protein-c-level-alterations-after-coagulation-activation-depend-on-type-of-thrombophilia-and-clinical-phenotype
#24
JOURNAL ARTICLE
Sara Reda, Nadine Schwarz, Jens Müller, Hannah L McRae, Johannes Oldenburg, Bernd Pötzsch, Heiko Rühl
BACKGROUND: Recently, we have shown alterations in the anticoagulant response to recombinant activated factor VII (rFVIIa)-induced coagulation activation in patients with thrombophilia. OBJECTIVES: This study aimed to extend this in vivo model to fibrinolysis biomarkers. METHODS: This interventional in vivo study included 56 patients with thrombophilia and previous venous thromboembolism (VTE+), 38 without VTE (VTE-), and 35 healthy controls...
February 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38487606/erratum-a-comparison-of-conventional-pap-smear-and-liquid-based-cytology-for-cervical-cancer-screening
#25
(no author information available yet)
[This corrects the article on p. 77 in vol. 12, PMID: 37416097.].
2024: Gynecology and Minimally Invasive Therapy
https://read.qxmd.com/read/38487006/sulfation-of-chondroitin-and-bile-acids-converges-to-antagonize-wnt-%C3%AE-catenin-signaling-and-inhibit-apc-deficiency-induced-gut-tumorigenesis
#26
JOURNAL ARTICLE
Pengfei Xu, Yue Xi, Jong-Won Kim, Junjie Zhu, Min Zhang, Meishu Xu, Songrong Ren, Da Yang, Xiaochao Ma, Wen Xie
Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology. 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the primary enzyme to generate the universal sulfonate donor PAPS. The involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli (APC) mutation-promoted colonic carcinogenesis has not been reported. Here, we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages, and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon cancer...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38483062/correlation-between-high-risk-hpv-infection-and-p16-ki-67-abnormalities-in-pap-samples-in-a-south-eastern-europe-cohort
#27
JOURNAL ARTICLE
Nevine A Shalaby, Claudiu Tudorescu-Morjan, Catalin Gabriel Manole, Alexandra-Antonela Iacata, Mirela Laura Popovici, Laura Iulia Grecu, Antoanela Curici
Cervical cancer (CC) is the fourth most common cause of cancer-related deaths amongst women worldwide. CC represents a major global healthcare issue, and Romania ranks the worst in mortality rates amongst EU countries. However, the early detection of CC can be lifesaving. To understand the testing process undergone by women in Romania, we performed a retrospective study, and investigated a cohort of 83 785 cervical cases from Romanian women aged 15-70, obtained in private-based opportunistic screening...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38482924/a-fluorescence-based-dual-sensor-for-zn-2-and-po-4-3-and-the-application-of-soft-computing-methods-to-predict-machine-learning-outcomes
#28
JOURNAL ARTICLE
Shashanka Shekhar Samanta, Subhadip Giri, Sourav Mandal, Usha Mandal, Hasibul Beg, Ajay Misra
A phenolphthalein-based Schiff base, 3,3-bis-{4-hydroxy-3-[(pyridine-2-ylmethylimino)-methyl]-phenyl}-3 H -isobenzofuran-1-one (PAP), has been synthesized and used for selective fluorescence 'turn on' and 'turn off' sensing of Zn2+ and PO4 3- respectively. The limit of detection using the 3 σ method for Zn2+ is found to be 19.3 nM and that for PO4 3- is 8.3 μM. The sensing mechanism of PAP for Zn2+ ions has been explained by 1 H NMR, 13 C NMR, TRPL, ESI-MS, FT-IR, and DFT based calculations. Taking advantage of this fluorescence 'on-off' behavior of PAP in the sequential presence of Zn2+ and PO4 3- a two input fuzzy logic (FL) operation has been constructed...
March 14, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38480766/a-pilot-observation-using-ultrasonography-and-vowel-articulation-to-investigate-the-influence-of-suspected-obstructive-sleep-apnea-on-upper-airway
#29
JOURNAL ARTICLE
Shumit Saha, Anand Rattansingh, Rosemary Martino, Keerthana Viswanathan, Anamika Saha, Nasim Montazeri Ghahjaverestan, Azadeh Yadollahi
Failure to employ suitable measures before administering full anesthesia to patients with obstructive sleep apnea (OSA) who are undergoing surgery may lead to developing complications after surgery. Therefore, it is very important to screen OSA before performing a surgery, which is currently done by subjective questionnaires such as STOP-Bang, Berlin scores. These questionnaires have 10-36% specificity in detecting sleep apnea, along with no information given on anatomy of upper airway, which is important for intubation...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479093/assessing-the-performance-and-utility-of-targeted-next-generation-sequencing-for-screening-and-genotyping-of-human-papillomaviruses
#30
JOURNAL ARTICLE
Jung Hoon Lee, Yun Mi Park, Jimyung Kim, Gye Cheol Kwon, Seon Young Kim
A next-generation sequencing (NGS)-based Ezplex HPV NGS kit (SML Genetree, Seoul, Korea) was used for human papillomavirus (HPV) screening. Of 885 cervical swab samples, HPV was detected in 162 samples. High-risk HPVs were detected in 82 samples, and other types of HPV were detected in 13 samples (HPV86, 71, 102, 91, and 114). At the read depth ≥ 500, NGS results exhibited 100 % agreement among repeated tests. HPV NGS results were compared with those of real-time PCR assays, Anyplex HPV28 (Seegene, Seoul, Korea) (n = 383) and Cobas HPV (Roche, Mannheim, Germany) (n = 64); concordances were 92...
February 16, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38476848/digital-patient-support-tool-innovative-solutions-for-enhanced-pap-adherence
#31
EDITORIAL
Ryo Tachikawa
No abstract text is available yet for this article.
January 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38476581/impact-of-warm-up-methods-on-strength-speed-for-sprinters-in-athletics-a-mini-review
#32
REVIEW
Eduardo Herrera, Cesar Osorio-Fuentealba
In athletics, achieving peak performance during competitions is crucial. Warm-up strategies play a crucial role in optimizing the strength-speed performance of sprinters in athletics, especially tailored to the physiological demands of speed events. The need to balance flexibility, prevent injuries, and enhance power output makes the selection of an effective warm-up protocol essential. This narrative review examines different warm-up methods used by athletes and their effects on strength-speed in sprinters in athletics...
2024: Frontiers in sports and active living
https://read.qxmd.com/read/38475258/preparation-and-properties-of-mechanically-robust-colorless-and-transparent-aramid-films
#33
JOURNAL ARTICLE
Heesang Kim, Jin-Hee Noh, Young-Rae Kim, Hyojin Kim, Giseop Kwak
In this study, various diamine monomers were used to synthesize aramid polymer films via a low-temperature solution condensation reaction with diacid chloride. For diamines with relatively high basicity, the reaction system became opaque because amine salt formation inhibited polymer synthesis. Meanwhile, low-basicity diamines with strong electron-withdrawing groups, such as CF3 and sulfone, were smoothly polymerized without amine salt formation to provide highly viscous solutions. The acid byproduct HCl generated during polymerization was removed by adding propylene oxide to the reaction vessel and converting the acid into highly volatile inert substances...
February 20, 2024: Polymers
https://read.qxmd.com/read/38474230/bioinformatic-analysis-of-sulfotransferases-from-an-unexplored-gut-microbe-sutterella-wadsworthensis-3_1_45b-possible-roles-towards-detoxification-via-sulfonation-by-members-of-the-human-gut-microbiome
#34
JOURNAL ARTICLE
Lauryn Langford, Dhara D Shah
Sulfonation, primarily facilitated by sulfotransferases, plays a crucial role in the detoxification pathways of endogenous substances and xenobiotics, promoting metabolism and elimination. Traditionally, this bioconversion has been attributed to a family of human cytosolic sulfotransferases (hSULTs) known for their high sequence similarity and dependence on 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a sulfo donor. However, recent studies have revealed the presence of PAPS-dependent sulfotransferases within gut commensals, indicating that the gut microbiome may harbor a diverse array of sulfotransferase enzymes and contribute to detoxification processes via sulfation...
March 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38470828/the-global-anesthesia-workforce-survey-updates-and-trends-in-the-anesthesia-workforce
#35
JOURNAL ARTICLE
Tyler J Law, Michael S Lipnick, Wayne Morriss, Adrian W Gelb, Jannicke Mellin-Olsen, Daniela Filipescu, Jackie Rowles, Pascal Rod, Fauzia Khan, Patrica Yazbeck, Eugene Zoumenou, Pedro Ibarra, Kumudini Ranatunga, Fred Bulamba
BACKGROUND: There is a large global deficit of anesthesia providers. In 2016, the World Federation of Societies of Anaesthesiologists (WFSA) conducted a survey to count the number of anesthesia providers worldwide. Much work has taken place since then to strengthen the anesthesia health workforce. This study updates the global count of anesthesia providers. METHODS: Between 2021 and 2023, an electronic survey was sent to national professional societies of physician anesthesia providers (PAPs), nurse anesthetists, and other nonphysician anesthesia providers (NPAPs)...
March 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38469284/the-effect-of-cpap-therapy-on-heart-rate-variability-in-patients-with-obstructive-sleep-apnea
#36
JOURNAL ARTICLE
Magda Grzęda-Hałon, Małgorzata Poręba, Gabriela Gut, Karolina Czerwińska, Paweł Gać, Helena Martynowicz, Grzegorz Mazur, Rafał Poręba
The aim of this study was to analyze the relationship between the initiation of CPAP therapy and HRV in patients with OSA. The study group consisted of 37 patients, aged 34-79 (mean 54.95 years) with OSA treated with CPAP. Two subgroups of patients were distinguished: less than severe (AHI < 30, n  = 16) and severe OSA (AHI ≥ 30, n  = 21). The second study was carried out around a month after the initiation of therapy. CPAP therapy caused the improvement in polysomnographic parameters, however, in most parameters in time and frequency analysis, there were no significant positive changes in parasympathetic tone...
April 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38463293/in-silico-structural-modeling-and-binding-site-analysis-of-cerebroside-sulfotransferase-cst-a-therapeutic-target-for-developing-substrate-reduction-therapy-for-metachromatic-leukodystrophy
#37
JOURNAL ARTICLE
Nivedita Singh, Anil Kumar Singh
Cerebroside sulfotransferase (CST) is emerging as an important therapeutic target to develop substrate reduction therapy (SRT) for metachromatic leukodystrophy (MLD), a rare neurodegenerative lysosomal storage disorder. MLD develops with progressive impairment and destruction of the myelin sheath as a result of accumulation of sulfatide around the nerve cells in the absence of its recycling mechanism with deficiency of arylsulfatase A (ARSA). Sulfatide is the product of the catalytic action of cerebroside sulfotransferase (CST), which needs to be regulated under pathophysiological conditions by inhibitor development...
March 5, 2024: ACS Omega
https://read.qxmd.com/read/38461880/successful-lung-transplantation-in-genetic-mars-related-alveolar-proteinosis-lung-fibrosis-without-recurrence-under-methionine-supplementation-medium-term-outcome-in-4-cases
#38
Charlotte Roy, Nathalie Allou, Aurore Coulomb, Dominique Grenet, Raphaël Borie, Benjamin Zuber, Abdulmonem Hamid, Matthieu Glorion, Anne-Laure Brun, Elizabeth Longchamps, Alice Hadchouel, Olivier Brugiere
Pulmonary alveolar proteinosis (PAP) results from the accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages, and can be associated with pulmonary fibrosis (PAP-PF), with a need for lung transplantation (LTx). Causes of PAP are autoimmune (90-95%), secondary (5%), or hereditary (<1%). Patients with hereditary PAP are generally not considered for isolated LTx, due to the high probability of recurrence after LTx, and only a challenging scenario with sequential LTx followed by HSCT was reported as successful...
March 8, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38461428/colposcopic-findings-to-study-cervical-changes-in-reproductive-age-group-women-using-various-contraceptives
#39
JOURNAL ARTICLE
Ritika Bist, Manjit Kaur Mohi, Rama Garg
BACKGROUND: Colposcopy has a key role to play in see-and-treat programs for premalignant cervical lesions. The aim of the study/was to observe cervical changes with a colposcope using the Swede scoring system in fertile age group women using various contraceptives: conventional methods (barrier methods, coitus interruptus), oral contraceptives (OCPs), copper-T and bilateral tubectomy. The aim of the study was to observe and evaluate the colposcopic findings using the Swede scoring system for the diagnosis of premalignant/malignant lesions in reproductive age group women using various contraceptives...
March 10, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38457098/characterizing-family-planning-utilization-in-adult-women-and-adolescents-in-pohnpei-federerated-states-of-micronesia
#40
JOURNAL ARTICLE
Katherine McDonald, Haley L Cash McGinley, Delpihn Abraham, Stephanie F Kapiriel, Marcy Lorrin
INTRODUCTION: Increasing family planning xutilization in low-income countries to improve health outcomes of women and children is a global priority. The Federated States of Micronesia (FSM) has poor maternal child health outcomes; therefore, this study aimed to examine family planning utilization in Pohnpei State, FSM. METHODS: This cross-sectional study sought to characterize family planning utilization in adult women of reproductive age and high school age adolescents in Pohnpei using representative survey data collected in 2019 (N = 570 and N = 1726, respectively)...
March 8, 2024: Maternal and Child Health Journal
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